A full online archive of references

March 2019


Ana Rodriguez-Mateos, Geoffrey Istas, Lisa Boschek, Rodrigo P Feliciano, Charlotte E Mills, Céline Boby, Sergio Gomez-Alonso, Dragan Milenkovic, Christian Heiss. Circulating anthocyanin metabolites mediate vascular benefits of blueberries: insights from randomized controlled trials, metabolomics, and nutrigenomicsThe Journals of Gerontology: Series A, 2019; DOI: 10.1093/gerona/glz047

Zgaga, L.; Laird, E.; Healy, M. 25-Hydroxyvitamin D Measurement in Human Hair: Results from a Proof-of-Concept study. Nutrients 201911, 423.

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease. Toufic Mayassi et al. Cell 2019, 176: 5. DOI:

Adjunctive vitamin D in tuberculosis treatment: meta-analysis of individual participant data. David A. Jolliffe, Davaasambuu Ganmaa, Christian Wejse, Rubhana Raqib, Md. Ahsanul Haq, Nawal Salahuddin, Peter K. Daley, Anna P. Ralph, Thomas R. Ziegler and Adrian R. Martineau. European Respiratory Journal, Published online February 6, 2019.

Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross‐over trial. Shaun A. Mason et al. Diabetes, Obesity and Metabolism, First published: 04 November 2018.

Lund KS, Siersma V, Brodersen J, et al. Efficacy of a standardised acupuncture approach for women with bothersome menopausal symptoms: a pragmatic randomised study in primary care (the ACOM study). BMJ Open 2019;9:e023637. doi: 10.1136/bmjopen-2018-023637.


  1. Bozdag G, Mumusoglu S, Zengin D, Karabulut E, Yildiz BO. The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod. 2016 Dec;31(12):2841-2855.
  2. Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018 May;14(5):270-284.
  3. Carmina E, Lobo RA. Use of fasting blood to assess the prevalence of insulin resistance in women with polycystic ovary syndrome. Fertil Steril. 2004 Sep;82(3):661-5.
  4. Barber TM, Dimitriadis GK, Andreou A, Franks S. Polycystic ovary syndrome: insight into pathogenesis and a common association with insulin resistance. Clin  Med (Lond). 2016 Jun;16(3):262-6.
  5. Azziz R, Carmina E, Chen Z, Dunaif A, Laven JS, Legro RS, Lizneva D, Natterson-Horowtiz B, Teede HJ, Yildiz BO. Polycystic ovary syndrome. Nat Rev Dis Primers. 2016 Aug 11;2:16057.
  6. Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018 May;14(5):270-284.
  7. Dokras A, Saini S, Gibson-Helm M, Schulkin J, Cooney L, Teede H. Gaps in knowledge among physicians regarding diagnostic criteria and management of polycystic ovary syndrome. Fertil Steril. 2017 Jun;107(6):1380-1386.e1.
  8. March WA, Moore VM, Willson KJ, Phillips DI, Norman RJ, Davies MJ. The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Hum Reprod. 2010 Feb;25(2):544-51.
  9. Neven ACH, Laven J, Teede HJ, Boyle JA. A Summary on Polycystic Ovary Syndrome: Diagnostic Criteria, Prevalence, Clinical Manifestations, and Management According to the Latest International Guidelines. Semin Reprod Med. 2018 Jan;36(1):5-12.
  10. Jarrett BY, Lin AW, Lujan ME. A Commentary on the New Evidence-Based Lifestyle Recommendations for Patients with Polycystic Ovary Syndrome and Potential Barriers to Their Implementation in the United States. J Acad Nutr Diet. 2019 Feb;119(2):205-210.
  11. Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018 May;14(5):270-284.
  12. Arentz S, Abbott JA, Smith CA, Bensoussan A. Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings. BMC Complement Altern Med. 2014 Dec 18;14:511.
  13. Moran LJ, et al. Dietary composition in the treatment of polycystic ovary syndrome: a systematic review to inform evidence-based guidelines. J Acad Nutr Diet. 2013 Apr;113(4):520-45
  14. Rondanelli M, Perna S, Faliva M, Monteferrario F, Repaci E, Allieri F. Focus on metabolic and nutritional correlates of polycystic ovary syndrome and update on nutritional management of these critical phenomena. Arch Gynecol Obstet. 2014  Dec;290(6):1079-92.
  15. Faghfoori Z, Fazelian S, Shadnoush M, Goodarzi R. Nutritional management in women with polycystic ovary syndrome: A review study. Diabetes Metab Syndr. 2017 Nov;11 Suppl 1:S429-S432.
  16. Moran LJ, Noakes M, Clifton PM, Tomlinson L, Galletly C, Norman RJ. Dietary composition in restoring reproductive and metabolic physiology in overweight women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2003 Feb;88(2):812-9.
  17. Stamets K, Taylor DS, Kunselman A, Demers LM, Pelkman CL, Legro RS. A randomized trial of the effects of two types of short-term hypocaloric diets on weight loss in women with polycystic ovary syndrome. Fertil Steril. 2004 Mar;81(3):630-7.
  18. Glueck CJ, Goldenberg N. Characteristics of obesity in polycystic ovary syndrome: Etiology, treatment, and genetics. Metabolism. 2019 Mar;92:108-120.
  19. Jarrett BY, Lujan ME. Impact of hypocaloric dietary intervention on ovulation  in obese women with PCOS. Reproduction. 2016 Oct 31. pii: REP-16-0385. (Epub ahead of print)
  20. Frary JM, Bjerre KP, Glintborg D, Ravn P. The effect of dietary carbohydrates  in women with polycystic ovary syndrome: a systematic review. Minerva Endocrinol. 2016 Mar;41(1):57-69.
  21. Sordia-Hernández LH, Ancer Rodríguez P, Saldivar Rodriguez D, Trejo Guzman S,Servín Zenteno ES, Guerrero González G, Ibarra Patiño R. Effect of a low glycemic diet in patients with polycystic ovary syndrome and anovulation – a randomized controlled trial. Clin Exp Obstet Gynecol. 2016;43(4):555-559.
  22. Goss AM, Chandler-Laney PC, Ovalle F, Goree LL, Azziz R, Desmond RA, Wright Bates G, Gower BA. Effects of a eucaloric reduced-carbohydrate diet on body composition and fat distribution in women with PCOS. Metabolism. 2014 Oct;63(10):1257-64.
  23. Phy JL, Pohlmeier AM, Cooper JA, Watkins P, Spallholz J, Harris KS, Berenson AB, Boylan M. Low Starch/Low Dairy Diet Results in Successful Treatment of Obesity and Co-Morbidities Linked to Polycystic Ovary Syndrome (PCOS). J Obes Weight Loss Ther. 2015 Apr;5(2).
  24. McGrice M, Porter J. The Effect of Low Carbohydrate Diets on Fertility Hormones and Outcomes in Overweight and Obese Women: A Systematic Review. Nutrients. 2017 Feb 27;9(3).
  25. Sutton P, Wallinga D, Perron J, Gottlieb M, Sayre L, Woodruff T. Reproductive  health and the industrialized food system: a point of intervention for health policy. Health Aff (Millwood). 2011 May;30(5):888-97.
  26. Vagi SJ, Azziz-Baumgartner E, Sjödin A, Calafat AM, Dumesic D, Gonzalez L, Kato K, Silva MJ, Ye X, Azziz R. Exploring the potential association between brominated diphenyl ethers, polychlorinated biphenyls, organochlorine pesticides, perfluorinated compounds, phthalates, and bisphenol A in polycystic ovary syndrome: a case-control study. BMC Endocr Disord. 2014 Oct 28;14:86.
  27. Yang Q, Zhao Y, Qiu X, Zhang C, Li R, Qiao J. Association of serum levels of typical organic pollutants with polycystic ovary syndrome (PCOS): a case-control  study. Hum Reprod. 2015 Aug;30(8):1964-73.
  28. Kandaraki E, Chatzigeorgiou A, Livadas S, Palioura E, Economou F, Koutsilieris M, Palimeri S, Panidis D, Diamanti-Kandarakis E. Endocrine disruptors and polycystic ovary syndrome (PCOS): elevated serum levels of bisphenol A in women with PCOS. J Clin Endocrinol Metab. 2011 Mar;96(3):E480-4.
  29. Zhou W, Fang F, Zhu W, Chen ZJ, Du Y, Zhang J. Bisphenol A and Ovarian Reserve among Infertile Women with Polycystic Ovarian Syndrome. Int J Environ Res Public Health. 2016 Dec 27;14(1).
  30. Hyland C, Bradman A, Gerona R, Patton S, Zakharevich I, Gunier RB, Klein K. Organic diet intervention significantly reduces urinary pesticide levels in U.S. children and adults. Environ Res. 2019 Jan 29. pii: S0013-9351(19)30024-6.
  31. Rudel RA, Gray JM, Engel CL, et al. Food packaging and bisphenol A and bis(2-ethyhexyl) phthalate exposure: findings from a dietary intervention. Environ Health Perspect. 2011 Jul;119(7):914-20. doi: 10.1289/ehp.1003170.
  32. He C, Lin Z, Robb SW, Ezeamama AE. Serum Vitamin D Levels and Polycystic Ovary syndrome: A Systematic Review and Meta-Analysis. Nutrients. 2015 Jun 8;7(6):4555-77.
  33. Wehr E, Pieber TR, Obermayer-Pietsch B. Effect of vitamin D3 treatment on glucose metabolism and menstrual frequency in polycystic ovary syndrome women: a  pilot study. J Endocrinol Invest. 2011 Nov;34(10):757-63.
  34. Pal L, Berry A, Coraluzzi L, Kustan E, Danton C, Shaw J, Taylor H. Therapeutic implications of vitamin D and calcium in overweight women with polycystic ovary syndrome. Gynecol Endocrinol. 2012 Dec;28(12):965-8.
  35. Irani M, Seifer DB, Grazi RV, Irani S, Rosenwaks Z, Tal R. Vitamin D Decreases Serum VEGF Correlating with Clinical Improvement in Vitamin D-Deficient Women with PCOS: A Randomized Placebo-Controlled Trial. Nutrients. 2017 Mar 28;9(4).
  36. Jamilian M, Foroozanfard F, Rahmani E, Talebi M, Bahmani F, Asemi Z. Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome. Nutrients. 2017 Nov 24;9(12).
  37. Ostadmohammadi V, Jamilian M, Bahmani F, Asemi Z. Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome. J Ovarian Res. 2019 Jan 21;12(1):5.
  38. Laganà AS, Garzon S, Casarin J, Franchi M, Ghezzi F. Inositol in Polycystic Ovary Syndrome: Restoring Fertility through a Pathophysiology-Based Approach. Trends Endocrinol Metab. 2018 Nov;29(11):768-780.
  39. Papaleo E, et al. Myo-inositol in patients with polycystic ovary  syndrome: a novel method for ovulation induction. Gynecol Endocrinol. 2007 Dec;23(12):700-3.
  40. Zeng L, Yang K. Effectiveness of myoinositol for polycystic ovary syndrome: a  systematic review and meta-analysis. Endocrine. 2018 Jan;59(1):30-38.
  41. Raffone E, Rizzo P, Benedetto V. Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women. Gynecol Endocrinol. 2010 Apr;26(4):275-80.
  42. Fruzzetti F, Perini D, Russo M, Bucci F, Gadducci A. Comparison of two insulin sensitizers, metformin and myo-inositol, in women with polycystic ovary syndrome  (PCOS). Gynecol Endocrinol. 2017 Jan;33(1):39-42.
  43. Zacchè MM, Caputo L, Filippis S, Zacchè G, Dindelli M, Ferrari A. Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome. Gynecol Endocrinol. 2009 Aug;25(8):508-13.
  44. Pezza M. Inositol in women suffering from acne and PCOS: a randomized study. Glob Dermatol, 2017. Volume 4(1): 3-4.
  45. Piotrowska A, Pilch W, Czerwińska-Ledwig O, Zuziak R, Siwek A, Wolak M, Nowak  G. The Possibilities of Using Chromium Salts as an Agent Supporting Treatment of  Polycystic Ovary Syndrome. Biol Trace Elem Res. 2019 Feb 4. doi: 10.1007/s12011-019-1654-5. (Epub ahead of print)
  46. Fazelian S, Rouhani MH, Bank SS, Amani R. Chromium supplementation and polycystic ovary syndrome: A systematic review and meta-analysis. J Trace Elem Med Biol. 2017 Jul;42:92-96.
  47. Amooee S, Parsanezhad ME, Ravanbod Shirazi M, Alborzi S, Samsami A. Metformin versus chromium picolinate in clomiphene citrate-resistant patients with PCOs: A double-blind randomized clinical trial. Iran J Reprod Med 2013; 11: 611-8.
  48. Amr N, Abdel-Rahim HE. The effect of chromium supplementation on polycystic ovary syndrome in adolescents. J Pediatr Adolesc Gynecol 2015; 28: 114-8.
  49. Oner G, Muderris II. Clinical, endocrine and metabolic effects of metformin vs N-acetyl-cysteine in women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2011 Nov;159(1):127-31.
  50. Javanmanesh F, Kashanian M, Rahimi M, Sheikhansari N. A comparison between the effects of metformin and N-acetyl cysteine (NAC) on some metabolic and endocrine  characteristics of women with polycystic ovary syndrome. Gynecol Endocrinol. 2016;32(4):285-9.
  51. Wang JG, Anderson RA, Graham GM 3rd, Chu MC, Sauer MV, Guarnaccia MM, Lobo RA. The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study. Fertil Steril. 2007 Jul;88(1):240-3.
  52. Kort DH, Lobo RA. Preliminary evidence that cinnamon improves menstrual cyclicity in women with polycystic ovary syndrome: a randomized controlled trial. Am J Obstet Gynecol. 2014 Nov;211(5):487.e1-6.
  53. Hajimonfarednejad M, Nimrouzi M, Heydari M, Zarshenas MM, Raee MJ, Jahromi BN. Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: A randomized double-blind placebo controlled clinical trial. Phytother Res. 2018 Feb;32(2):276-283.
  54. Akdoğan M, Tamer MN, Cüre E, Cüre MC, Köroğlu BK, Delibaş N. Effect of spearmint (Mentha spicata Labiatae) teas on androgen levels in women with hirsutism. Phytother Res. 2007 May;21(5):444-7.
  55. Grant P. Spearmint herbal tea has significant anti-androgen effects in polycystic ovarian syndrome. A randomized controlled trial. Phytother Res. 2010 Feb;24(2):186-8
  56. Haj-Husein I, Tukan S, Alkazaleh F. The effect of marjoram (Origanum majorana) tea on the hormonal profile of women with polycystic ovary syndrome: a randomised controlled pilot study. J Hum Nutr Diet. 2016 Feb;29(1):105-11.
  57. Heidary M, Yazdanpanahi Z, Dabbaghmanesh MH, Parsanezhad ME, Emamghoreishi M,  Akbarzadeh M. Effect of chamomile capsule on lipid- and hormonal-related parameters among women of reproductive age with polycystic ovary syndrome. J Res  Med Sci. 2018 Apr 26;23:33.

HYBRID DIET – Patrick Holford

  1. Sarah J. Hallberg et al Effectiveness and Safety of a Novel Care Model for the Management of Type 2 Diabetes at 1 Year: An Open-Label, Non-Randomized, Controlled Study

Diabetes Therapy April 2018, Volume 9, Issue 2, pp 583–612.

  1. Courchesne-Loyer A, et al., ‘Inverse relationship between brain glucose and ketone metabolism in adults during short-term moderate dietary ketosis: A dual tracer quantitative positron emission tomography study.’ 2017 Jul;37(7):2485-2493; see also Cunnane SC et al., ‘Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer’s Disease.’J Cereb Blood Flow Metab. 2017 Jul;37(7):2485-2493
  3. Wang C1 et al Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases.Curr Opin Neurobiol. 2018 Feb;48:52-58.
  4. E. White, ‘Autophagy, metabolism, and cancer’, Clinical Cancer Research (2015), 21(22):5037–5046.
  5. Bueno NB et al Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials. Br J Nutr. 2013 Oct;110(7):1178-87.


  1. David S. Ludwig The case against carbohydrates gets stronger LA Times Nov 14, 2018
  2. J.M. Chan, et al., ‘Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study’, Science (1998), vol 279(5350):563–566; see also M.J. Gunter et al., ‘Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women’, Journal of the National Cancer Institute (2009), vol 101(1):48–60.=
  3. Vandenberghe et al., ‘Tricaprylin alone increases plasma ketone response more than coconut oil or other medium-chain triglycerides: an acute crossover study in healthy adults’, Current Developments in Nutrition (2017), vol 1(4):e000257.
    10. C. Ebbeling et al., ‘Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial’ British Medical Journal 2018;363:k4583
  4. P.M. Johnson and P.J. Kenny, ‘Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats’, Nature Neuroscience (2010), vol 13(5)–635–641.


Kim Vriens et al. Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticityNature, 2019; DOI: 10.1038/s41586-019-0904-1.

Jeewon Garcia-So, Xinwen Zhang, Xiaohua Yang, Mara Roxana Rubinstein, De Yu Mao, Jan Kitajewski, Kang Liu, Yiping W. Han. 

Omega-3 fatty acids suppress Fusobacterium nucleatum–induced placental inflammation originating from maternal endothelial cellsJCI Insight, 2019; 4 (3) DOI: 10.1172/jci.insight.125436.

Poorna ChandraRao Yalagala, Dhavamani Sugasini, Sridevi Dasarathi, Kalipada Pahan, Papasani V. Subbaiah. Dietary lysophosphatidylcholine-EPA enriches both EPA and DHA in the brain: Potential treatment for depressionJournal of Lipid Research, 2018; jlr.M090464 DOI: 10.1194/jlr.M090464.

Association of reported fish intake and supplementation status with the omega-3 index.

K.H. Jackson et al. Prostaglandins, Leukotrienes and Essential Fatty Acids

Vol142, March 2019, 4-10: DOI:

Marine fish oil is more potent than plant-based n-3 polyunsaturated fatty acids in the prevention of mammary tumors. JiajieLiu et al. The Journal of Nutritional Biochemistry

Volume 55, May 2018, Pages 41-52

LYME – Dr Bill Rawls.

  1. Berende A, ter Hofstede HJ, Vos FJ, et al. Randomized Trial of Longer-Term Therapy for Symptoms Attributed to Lyme Disease. N Engl J Med. 2016;374(13):1209-1220.
    2.Rudenko N, Golovchenko M, Vancova M, et al. Isolation of live Borrelia burgdorferi senso lato spirochaetes from patients with undefined disorders and symptoms not typical for Lyme borreliosis. Clin Microb Infect. 2016;22(3):267. Epub 2015 Dec 8.
    3. Perez-Cobas AE, Gosalbes MJ, Friedrichs A, et al. Gut microbiota disturbance during antibiotic therapy, a multi-omic approach. Gut. 2013;62(11):1591-1601. Epub 2012 Dec 12.
    4. Morgun A, Dzutsev A, Dong X, et al. Uncovering effects of antibiotics on the host and microbiota using transkingdom gene networks. Gut. 2015;64(11):1732-1742. Epub 2015 Jan 22.
    5. Kalghatgi S, Spina CS, Costello JC, et al. Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells. Sci Transl Med. 2013;5(192):192ra85.
    6. Macfarlane S, Woodmansey EJ, Macfarlane GT. Colonization of mucin by human intestinal bacteria and establishment of biofilm communities in a two-stage continuous culture system. Appl Environ Microbiol. 2005;71(11):7483-7492.
    7. Macfarlane S, Dillon JF. Microbial biofilms in the human gastrointestinal tract. J Appl Microbiol. 2007;102(5):1187-1196.
    8. Macfarlane S, Bahrami B, Macfarlane GT. Mucosal biofilm communities in the human intestinal tract. Adv Appl Microbiol. 2011;75:111-143.


Ting Fu et al. FXR Regulates Intestinal Cancer Stem Cell ProliferationCell, 2019; 176 (5): 1098 DOI: 10.1016/j.cell.2019.01.036.

Xin Wu, Jing Shi, Wan-xia Fang, Xiao-yu Guo, Ling-yun Zhang, Yun-peng Liu, Zhi Li. Allium vegetables are associated with reduced risk of colorectal cancer: A hospital-based matched case-control study in ChinaAsia-Pacific Journal of Clinical Oncology, 2019; DOI: 10.1111/ajco.13133


Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal. Doua Azzouz et al. Annals of the Rheumatic Diseases. Published Online First: 19 February 2019. doi: 10.1136/annrheumdis-2018-214856.

 Old age-associated phenotypic screening for Alzheimer’s disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa

Wolfgang Fischer, Antonio Currais, Zhibin Liang, Antonio Pinto and Pamela Maher.

Redox Biology, Volume 21, February 2019, 101089

open access:

Haruki Nakamura, Akinori Hara, Hiromasa Tsujiguchi, Thao Thi Thu Nguyen, Yasuhiro Kambayashi, Sakae Miyagi, Yohei Yamada, Keita Suzuki, Yukari Shimizu, Hiroyuki Nakamura. Relationship between Dietary n-6 Fatty Acid Intake and Hypertension: Effect of Glycated Hemoglobin LevelsNutrients, 2018; 10 (12): 1825 DOI: 10.3390/nu10121825

Stephen J. Carter, Gary R. Hunter, J. Walker Blackston, Nianjun Liu, Elliot J. Lefkowitz, William J. Van Der Pol, Casey D. Morrow, Jesseca A. Paulsen, Laura Q. Rogers. Gut microbiota diversity associates with cardiorespiratory fitness in post-primary treatment breast cancer survivorsExperimental Physiology, 2019; DOI: 10.1113/EP087404.

Philip Strandwitz, Ki Hyun Kim, Darya Terekhova, Joanne K. Liu, Anukriti Sharma, Jennifer Levering, Daniel McDonald, David Dietrich, Timothy R. Ramadhar, Asama Lekbua, Nader Mroue, Conor Liston, Eric J. Stewart, Marc J. Dubin, Karsten Zengler, Rob Knight, Jack A. Gilbert, Jon Clardy, Kim Lewis. GABA-modulating bacteria of the human gut microbiotaNature Microbiology, 2018; DOI: 10.1038/s41564-018-0307-3.

Asher Preska Steinberg, Sujit S Datta, Thomas Naragon, Justin C Rolando, Said R Bogatyrev, Rustem F Ismagilov. High-molecular-weight polymers from dietary fibre drive aggregation of particulates in the murine small intestineeLife, 2019 DOI: 10.7554/eLife.40387.001.

Luoping Zhang, Iemaan Rana, Rachel M. Shaffer, Emanuela Taioli, Lianne Sheppard. Exposure to Glyphosate-Based Herbicides and Risk for Non-Hodgkin Lymphoma: A Meta-Analysis and Supporting EvidenceMutation Research/Reviews in Mutation Research, 2019; DOI: 10.1016/j.mrrev.2019.02.001.

Petra Bacher et al. Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicansCell, 2019; DOI: 10.1016/j.cell.2019.01.041.

Puneet Seth, Paishiun N. Hsieh, Suhib Jamal, Liwen Wang, Steven P. Gygi, Mukesh K. Jain, Jeff Coller, Jonathan S. Stamler. Regulation of MicroRNA Machinery and Development by Interspecies S-NitrosylationCell, Feb. 21, 2019; DOI: 10.1016/j.cell.2019.01.037

AONM Advertorial:

1. Moutailler S, Valiente Moro C, Vaumourin E, Michelet L, Tran FH, Devillers E, et al. (2016)
Co-infection of Ticks: The Rule Rather Than the Exception. PLoS Negl Trop Dis 10(3):
2. Johnson, L., Wilcox, S., Mankoff, J., & Stricker, R. B. (2014). Severity of chronic Lyme disease
compared to other chronic conditions: a quality of life survey. PeerJ, 2, e322.
3. Birtles, R. J., Laycock, G., Kenny, M. J., Shaw, S. E. & Day, M. J. (2002). Prevalence of
Bartonella species causing bacteraemia in domesticated and companion animals in the
United Kingdom. Vet Rec 151, 225–229.
5. Davies, S, Abdullah, S, Helps, C, Tasker, S, Newbury, H & Wall, R 2017, ‘Prevalence of ticks
and tick-borne pathogens: Babesia and Borrelia species in ticks infesting cats of Great Britain’
Veterinary Parasitology, vol. 244, pp. 129-135
7. Mansfield, K. L., Jizhou, L., Phipps, L. P., & Johnson, N. (2017). Emerging Tick-Borne Viruses in
the Twenty-First Century. Frontiers in cellular and infection microbiology, 7, 298

February 2019


Martami F et al The effects of a multispecies probiotic supplement on inflammatory markers and episodic and chronic migraine characteristics: A randomized double-blind controlled trial. Cephalalgia. Jan 2019.

Christian Timbol, James Baraniuk. Chronic fatigue syndrome in the emergency departmentOpen Access Emergency Medicine, 2019; Volume 11: 15 DOI: 10.2147/OAEM.S176843

Qi Dai, Xiangzhu Zhu, JoAnn E Manson, Yiqing Song, Xingnan Li, Adrian A Franke, Rebecca B Costello, Andrea Rosanoff, Hui Nian, Lei Fan, Harvey Murff, Reid M Ness, Douglas L Seidner, Chang Yu, Martha J Shrubsole. Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trialThe American Journal of Clinical Nutrition, 2018; 108 (6): 1249 DOI: 10.1093/ajcn/nqy274

Anne Marie Uwitonze, Mohammed S. Razzaque. Role of Magnesium in Vitamin D Activation and FunctionThe Journal of the American Osteopathic Association, 2018; 118 (3): 181 DOI: 10.7556/jaoa.2018.037

Chester R, Khondoker M, Shepstone L, et al. Self-efficacy and risk of persistent shoulder pain: results of a Classification and Regression Tree (CART) analysis

Br J Sports Med Published Online First: 09 January 2019. doi: 10.1136/bjsports-2018-099450.

Kate L Mandeville, Rosie Barker, Alice Packham, Charlotte Sowerby, Kielan Yarrow, Hannah Patrick. Financial interests of patient organisations contributing to technology assessment at England’s National Institute for Health and Care Excellence: policy review.BMJ. DOI: 10.1136/BMJ.K5300

Hall, K et al. COMT modifies alpha-tocopherol effects in cancer prevention: gene-supplement interactions in two randomized clinical trialsJNCI, 2019 DOI: 10.1093/jnci/djy204.

Tamara Lucas, Richard Horton. The 21st-century great food transformationThe Lancet, 2019; DOI: 10.1016/S0140-6736(18)33179-9.


  1. Ford AC, Marwaha A, Sood R, Moayyedi P. Global prevalence of, and risk factors for, uninvestigated dyspepsia: a meta-analysis. Gut. 2015 Jul;64(7):1049-57.
  2. Talley NJ, Walker MM, Holtmann G. Functional dyspepsia. Curr Opin Gastroenterol. 2016 Nov;32(6):467-473.
  3. Stanghellini V, Chan FK, Hasler WL, Malagelada JR, Suzuki H, Tack J, Talley NJ. Gastroduodenal Disorders. Gastroenterology. 2016 May;150(6):1380-92.
  4. Tack J, Carbone F, Holvoet L, Vanheel H, Vanuytsel T, Vandenberghe A. The use  of pictograms improves symptom evaluation by patients with functional dyspepsia. Aliment Pharmacol Ther. 2014 Sep;40(5):523-30.
  5. Talley NJ, Ford AC. Functional dyspepsia. N Engl J Med 2015; 373:1853– 1863.
  6. Enck P, Azpiroz F, Boeckxstaens G, Elsenbruch S, Feinle-Bisset C, Holtmann G,  Lackner JM, Ronkainen J, Schemann M, Stengel A, Tack J, Zipfel S, Talley NJ. Functional dyspepsia. Nat Rev Dis Primers. 2017 Nov 3;3:17081
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Sonnenburg ED, Smits SA, Tikhonov M, Higginbottom SK, Wingreen NS, Sonnenburg JL. Nature 2016, Jan 14;529(7585):212-5

  1. Logan AC, Jacka FN, Prescott SL. Immune-Microbiota Interactions: Dysbiosis as a Global Health Issue. Curr Allergy Asthma Rep. 2016 Jan;16(2):13.

 NUTRIGENOMICS – Kara Fitzgerald

  1. Understanding the regulatory and transcriptional complexity of the genome through structure. Tim R. Mercer and John S. Mattick. Genome Res. 2013 Jul; 23(7): 1081–1088.

doi: 10.1101/gr.156612.113.

  1. Lobo, I. (2008) Epistasis: Gene interaction and the phenotypic expression of complex diseases like Alzheimer’s. Nature Education1(1):180.
  2. Major Heart Disease Genes Prove Elusive. Jennifer Couzin-Frankel. Science 04 Jun 2010: Vol. 328, Issue 5983, pp. 1220-21. DOI: 10.1126/science.328.5983.1220.
    4. The Elusive ALS Genes. Ken Garber. Science 04 Jan 2008: Vol. 319, Issue 5859, pp. 20
    DOI: 10.1126/science.319.5859.20.
    5. Genes and Autoimmune Diseases — A Complex Inheritance. Highlights of the 54th Annual Meeting of the American Society of Human Genetics; October 26-30, 2004; Toronto, Ontario, Canada. Sara M Mariani, PhD. MedGenMed. 2004; 6(4): 18.
  3. Combined effect of CYP1B1COMTGSTP1, and MnSODgenotypes and risk of postmenopausal breast cancer. J Gynecol Oncol. 2011 Jun 30; 22(2): 110–119.

doi: 10.3802/jgo.2011.22.2.110.

  1. Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Fredrick R. Schumacher et al. Nature Genetics, 2018, 50: 928–936.
  2. Heather M. Ochs-Balcom et al. Physical activity modifies genetic susceptibility to obesity in postmenopausal women. Menopause, 2018; 1 DOI: 10.1097/GME.0000000000001134.

Ossenkoppele R, Rabinovici GD, Smith R, et al. Discriminative Accuracy of [18F]flortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative Disorders. JAMA, 2018; 320 (11): 1151–1162 DOI: 10.1001/jama.2018.12917.

Adam P Spira, Yang An, Mark N Wu, Jocelynn T Owusu, Eleanor M Simonsick, Murat Bilgel, Luigi Ferrucci, Dean F Wong, Susan M Resnick. Excessive daytime sleepiness and napping in cognitively normal adults: associations with subsequent amyloid deposition measured by PiB PET. Sleep, 2018; DOI: 10.1093/sleep/zsy152.

Ross S. Mancini, Yanfei Wang, Donald F. Weaver. Phenylindanes in Brewed Coffee Inhibit Amyloid-Beta and Tau Aggregation. Frontiers in Neuroscience, 2018; 12 DOI: 10.3389/fnins.2018.00735.


Nutritional status, brain network organization, and general intelligence

Marta K.Zamroziewicz et al. NeuroImage, Volume 161, 1 November 2017, Pages 241-250.

Maternal Dietary Choline Status Influences Brain Gray and White Matter Development in Young Pigs. Austin T Mudd et al. Current Developments in Nutrition, 2: 6, 1 June 2018,


Makrides, L Duley, SF Olsen. Fish oil and other prostaglandin precursor supplementation during pregnancy for reducing pre-eclampsia, preterm birth, low birth weight and intrauterine growth restriction. Cochrane Review, 2018 DOI:

Long-term intake of vegetables and fruits and subjective cognitive function in US men.

Changzheng Yuan, Elinor Fondell, Ambika Bhushan, Alberto Ascherio, Olivia I. Okereke, Francine Grodstein, Walter C. Willett. Neurology 2018, first published Nov 21, 2018, DOI:

Angele M. De Silva, Rían W. Manville, Geoffrey W. Abbott. Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activationScience Advances, 2018; 4 (11): eaav0824 DOI: 10.1126/sciadv.aav0824

 Wahl D et al. Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice. Cell Rep. 2018 Nov 20;25(8):2234-2243.e6. doi: 10.1016/j.celrep.2018.10.070.

Salas-Huetos A et al. The Effect of Nutrients and Dietary Supplements on Sperm Quality Parameters: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Advances in Nutrition, 2018; 9(6), 833-848. DOI: 10.1093/advances/nmy057.

Calorie restriction
1.  Cash A. Oxaloacetic Acid Supplementation as a Mimetic of Calorie Restriction. Open Longevity Science. 2009;3:22-7.

  1. Williams DS, Cash A, Hamadani L, Diemer T. Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Aging Cell. 2009;8(6):765-8.
  2. Shintani H, Shintani T, Ashida H, Sato M. Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose Metabolism. Nutrients. 2018;10(12): open access at
  3. Lane, M.A; Ingram, D.K; Roth, G.S. 2-Deoxy-D-glucose feeding in rats mimics physiologic effects of calorie restriction. J. Anti Aging Med. 1998, 1, 327-337.

Gut-brain mechanism
1. Pellegrini C et al (2018) Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases? Acta Neuropathol 136:345. doi:10.1007/s00401-018-1856-5.

  1. Kaelberer et al (2018) A gut-brain neural circuit for nutrient sensory transduction. Science 361(6408):eaat5236. doi:10.1126/science.aat5236.
  2. Bohórquez and Liddle (2015) The gut connectome: making sense of what you eat. J Clin Invest125(3):888–890. doi:10.1172/JCI81121.


  1. Urolithin A induces mitophagy and prolongs lifespan in C. elegansand increases muscle function in rodents. Dongryeol Ryu et al. Nature Medicine 2016, 22: 879–88.
  2. Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials. Carine Dion, Eric Chappuis, and Christophe Ripoll. Nutr Metab (Lond) 2016, 13: 28, doi:  10.1186/s12986-016-0086-x.
November 2018


 Precision identification of diverse bloodstream pathogens in the gut microbiome. Tamburini FB, Andermann TM, Tkachenko E, Senchyna F, Banaei N, Bhatt AS. Nat Med. 2018 Oct 15. doi: 10.1038/s41591-018-0202-8.

Development of the Highly Processed Food Withdrawal Scale. Appetite 2018,

Vol 131, 1 December, 148-154.

Bruce N. Ames. Prolonging healthy ageing: Longevity vitamins and proteins, Proceedings of the National Academy of Sciences (2018). DOI: 10.1073/pnas.1809045115 

Bruce N. Ames. Low micronutrient intake may accelerate the degenerative diseases of ageing through allocation of scarce micronutrients by triage. PNAS November 21, 2006 103 (47) 17589-17594;


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  16. Zeisel SH. Nutrition in pregnancy: the argument for including a source of choline. Int J Womens Health. 2013 Apr 22;5:193-9.
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  18. Ross RG, Hunter SK, McCarthy L, Beuler J, Hutchison AK, Wagner BD, Leonard S,  Stevens KE, Freedman R. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013 Mar;170(3):290-8.
  19. Ross RG, Hunter SK, Hoffman MC, McCarthy L, Chambers BM, Law AJ, Leonard S, Zerbe GO, Freedman R. Perinatal Phosphatidylcholine Supplementation and Early Childhood Behavior Problems: Evidence for CHRNA7 Moderation. Am J Psychiatry. 2016 May 1;173(5):509-16.
  20. Ideraabdullah FY, Zeisel SH. Dietary Modulation of the Epigenome. Physiol Rev. 2018 Apr 1;98(2):667-695.
  21. Stephenson J, Heslehurst N, Hall J, Schoenaker DAJM, Hutchinson J, Cade JE, Poston L, Barrett G, Crozier SR, Barker M, Kumaran K, Yajnik CS, Baird J, Mishra  GD. Before the beginning: nutrition and lifestyle in the preconception period and its importance for future health. Lancet. 2018 May 5;391(10132):1830-1841.


Mingfei Zhao, Brian W Whitcomb, Alexandra C Purdue-Smithe, JoAnn E Manson, Susan E Hankinson, Bernard A Rosner, Elizabeth R Bertone-Johnson. Physical activity is not related to risk of early menopause in a large prospective studyHuman Reproduction, 2018; DOI: 10.1093/humrep/dey267.

Yashvee Dunneram, Darren Charles Greenwood, Victoria J Burley, Janet E Cade. Dietary intake and age at natural menopause: results from the UK Women’s Cohort StudyJournal of Epidemiology and Community Health, 2018; DOI: 10.1136/jech-2017-209887

  1. Reduce hot flashes and other menopausal symptoms: a beneficial proprietary Siberian rhubarb root extract, Kristen Haabala, ND, and Mark Kaye, DC. Naturopathic Doctor News and Review, posted Dec 7, 2012:
    2. A Non-Hormone Approach to Menopause Management, by Stephanie Clark. Life Extension Magazine, October 2018.

Fiona S Atkinson, Dale Hancock, Peter Petocz, Jennie C Brand-Miller. The physiologic and phenotypic significance of variation in human amylase gene copy number. The American Journal of Clinical Nutrition, 2018; 108 (4): 737 DOI: 10.1093/ajcn/nqy164

  1. Falchi et al. Low copy number of the salivary amylase gene predisposes to obesity. Nature Genetics, 2014 DOI: 10.1038/ng.2939

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase. Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-018-06158-5.

Suleiman Furmli, Rami Elmasry, Megan Ramos, Jason Fung. Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulinBMJ Case Reports, 2018; bcr-2017-221854 DOI: 10.1136/bcr-2017-221854

White J, Xiong S, Malvin N, Khoury-Hanold W, Heuckeroth R, Stappenbeck T, Diamond MS. Intestinal dysmotility syndromes following system infection by flaviviruses. Cell. Oct, 4, 2018.


October 2018


Jørgensen L, Gøtzsche P, Jefferson T. The Cochrane HPV vaccine review was incomplete and ignored important evidence of bias. BMJ Evid Based Med 2018, Jul 27.
Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors. Cochrane Database Syst Rev2018;5:CD009069.pmid:29740819.

Index of the human papillomavirus (HPV) vaccine industry clinical study programmes and non-industry funded studies: a necessary basis to address reporting bias in a systematic review. Syst Rev 2018;7:8. doi:10.1186/s13643-018-0675-z pmid:29347995.

HPV vaccine safety: Cochrane launches urgent investigation into review after criticisms. BMJ 2018; 362 doi: (Published 09 August 2018).

Greenhalgh T, Howick J, Maskrey N; Evidence Based Medicine Renaissance Group. Evidence based medicine: a movement in crisis? BMJ. 2014 Jun 13;348:g3725. doi: 10.1136/bmj.g3725.

 Resveratrol Supplementation Reduces Pain and Inflammation in Knee Osteoarthritis Patients Treated with Meloxicam: A Randomized Placebo-Controlled Study. Published Online ahead of print Journal of Medicinal Food, August 30, 2018: (Free access to October 17.)

Cell 2018 Sep 6;174(6):1388-1405.e21. doi: 10.1016/j.cell.2018.08.041.

Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features.

A randomized placebo-controlled clinical trial of a multi-strain probiotic formulation

(Bio-Kult®) in the management of diarrhea-predominant irritable bowel syndrome.

Ishaque et al. BMC Gastroenterology 2018, 18:71:

Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome

Gastroenterology, Volume 153, Issue 2, August 2017, Pages 448-459.e8.

Does probiotic consumption reduce antibiotic utilization for common acute infections? A systematic review and meta-analysis 

European Journal of Public Health, cky185,

Published: 14 September 2018.

Qingqing Zhang, Yucheng Wu, Xiaoqiang Fei. Effect of probiotics on body weight and body-mass index: a systematic review and meta-analysis of randomized, controlled trialsInternational Journal of Food Sciences and Nutrition, 2016; 67 (5): 571 DOI: 10.1080/09637486.2016.1181156.

Elmira Akbari, Zatollah Asemi, Reza Daneshvar Kakhaki, Fereshteh Bahmani, Ebrahim Kouchaki, Omid Reza Tamtaji, Gholam Ali Hamidi, Mahmoud Salami. Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer’s Disease: A Randomized, Double-Blind and Controlled TrialFrontiers in Aging Neuroscience, 2016; 8 DOI: 10.3389/fnagi.2016.00256

Anna G. Nilsson, Daniel Sundh, Fredrik Bäckhed, Mattias Lorentzon. Lactobacillus reuteri reduces bone loss in older women with low bone mineral density – a randomized, placebo-controlled, double-blind, clinical trialJournal of Internal Medicine, 2018; DOI: 10.1111/joim.12805.


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Glutamine not for cancer
Gaurav Pathria, David A Scott, Yongmei Feng, Joo Sang Lee, Yu Fujita, Gao Zhang, Avinash D Sahu, Eytan Ruppin, Meenhard Herlyn, Andrei L Osterman, Ze’ev A Ronai. Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survivalThe EMBO Journal, 2018; e99735 DOI: 10.15252/embj.201899735


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Anna G. Nilsson, Daniel Sundh, Fredrik Bäckhed, Mattias Lorentzon. Lactobacillus reuteri reduces bone loss in older women with low bone mineral density – a randomized, placebo-controlled, double-blind, clinical trialJournal of Internal Medicine, 2018; DOI: 10.1111/joim.12805

Rick Kapur, Michael Kim, Johan Rebetz, Björn Hallström, Jonas T. Björkman, Alisa Takabe-French, Noel Kim, Jonathan Liu, Shanjeevan Shanmugabhavananthan, Stefan Milosevic, Mark J. McVey, Edwin R. Speck, John W. Semple. Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injuryBlood Advances, 2018; 2 (13): 1651 DOI: 10.1182/bloodadvances.2018018903

Annabelle M. Watts, Amanda J. Cox, Peter K. Smith, Isolde Besseling-van der Vaart, Allan W. Cripps, and Nicholas P. West. The Journal of Alternative and Complementary Medicine. Aug 2018, ahead of print:

Satish S. C. Rao, Abdul Rehman, Siegfried Yu, Nicole Martinez de Andino. Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosisClinical and Translational Gastroenterology, 2018; 9 (6) DOI: 10.1038/s41424-018-0030-7.

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Cindy W Leung, Teresa T Fung, Claire T McEvoy, Jue Lin, Elissa S Epel. Diet Quality Indices and Leukocyte Telomere Length among Healthy US Adults: Data from the National Health and Nutrition Examination Surveys (NHANES) 1999-2002. American Journal of Epidemiology, 2018; DOI: 10.1093/aje/kwy124.

Pre-Exercise Breakfast Ingestion versus Extended Overnight Fasting Increases Postprandial Glucose Flux after Exercise in Healthy Men. American Journal of Physiology-Endocrinology and Metabolism, 2018; DOI: 10.1152/ajpendo.00163.2018

The relationship between adiposity and cognitive function in a large community-dwelling population: data from the Trinity Ulster Department of Agriculture (TUDA) ageing cohort study. British Journal of Nutrition, 2018:

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Bischof GN, Rodrigue KM, Kennedy KM, Devous MD Sr, Park DC. Amyloid deposition in younger adults is linked to episodic memory performance. Neurology. 2016 Dec 13;87(24):2562-2566. Epub 2016 Nov 11 PubMed.

Farrell ME, Kennedy KM, Rodrigue KM, Wig G, Bischof GN, Rieck JR, Chen X, Festini SB, Devous MD Sr, Park DC.Association of Longitudinal Cognitive Decline With Amyloid Burden in Middle-aged and Older Adults: Evidence for a Dose-Response Relationship. JAMA Neurol. 2017 Jul 1;74(7):830-838. PubMed.

Amariglio RE, Becker JA, Carmasin J, Wadsworth LP, Lorius N, Sullivan C, Maye JE, Gidicsin C, Pepin LC, Sperling RA, Johnson KA, Rentz DM. Subjective cognitive complaints and amyloid burden in cognitively normal older individuals. Neuropsychologia. 2012 Oct;50(12):2880-6. PubMed.

Phylogeny-corrected identification of microbial gene families relevant to human gut colonization. PLOS Computational Biology, August 9, 2018:

A Phenome-Wide Association Study Uncovers a Role for Autoimmunity in the Development of Chronic Obstructive Pulmonary Disease. American Journal of Respiratory Cell and Molecular Biology, 2018; 58 (6): 777 DOI: 10.1165/rcmb.2017-0409LE

Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for β Cell Recovery. Cell Metabolism, 2018,

Published: August 02:

August 2018


Complementary Medicine, Refusal of Conventional Cancer Therapy, and Survival Among Patients With Curable Cancers

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Jahnabi Roy et al. Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides, Journal of Medicinal Chemistry (2018). DOI: 10.1021/acs.jmedchem.8b00243

Gut Microbiota Composition is Related to Cardiorespiratory Fitness in Healthy Young AdultsInternational Journal of Sport Nutrition and Exercise Metabolism, 2018; 1 DOI: 10.1123/ijsnem.2018-0024

Voluntary fortification is ineffective to maintain the vitamin B12 and folate status of older Irish adults: evidence from the Irish Longitudinal Study on Ageing (TILDA)British Journal of Nutrition, 2018; 120 (01): 111 DOI: 10.1017/S0007114518001356.

Continuity of care with doctors—a matter of life and death? A systematic review of continuity of care and mortality. BMJ Open, 8:6.

Long-Term Acupuncture Therapy for Low-Income Older Adults with Multimorbidity: A Qualitative Study of Patient Perceptions.

J Altern Complement Med. 2018 Feb;24(2):161-167. doi: 10.1089/acm.2017.0239. Epub 2017 Oct 23.


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Ghosh SS, Gehr TWB, Ghosh S (2014) Curcumin and Chronic Kidney Disease (CKD): Major Mode of Action through Stimulating Endogenous Intestinal Alkaline Phosphatase. Molecules vol 19, 20139-20156; doi:10.3390/molecules191220139

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Reversal of cognitive decline: A novel therapeutic program

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Brain training:

Dr Ritchie Shoemaker (author of Surviving Mold):

Cyrex 2 and 3: available in the UK from Regenerus:

Joonseok Kim, Jaehyoung Choi, Soo Young Kwon, John W. McEvoy, Michael J. Blaha, Roger S. Blumenthal, Eliseo Guallar, Di Zhao, Erin D. Michos. Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease. Circulation: Cardiovascular Quality and Outcomes, 2018; 11 (7): e004224 DOI: 10.1161/CIRCOUTCOMES.117.004224

Supplemental Vitamins and Minerals for CVD Prevention and Treatment. Journal of the American College of Cardiology, 2018; 71 (22): 2570 DOI: 10.1016/j.jacc.2018.04.020

Roberto Sansone, Ana Rodriguez-Mateos, Jan Heuel, David Falk, Dominik Schuler, Rabea Wagstaff, Gunter G. C. Kuhnle, Jeremy P. E. Spencer, Hagen Schroeter, Marc W. Merx, Malte Kelm, Christian Heiss. Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study. British Journal of Nutrition, 2015; 1 DOI: 10.1017/S0007114515002822.

Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis. BMJ Open Heart, 2018, 5:1.

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Eur J Clin Nutr. 2012 Nov;66(11):1234-41. doi: 10.1038/ejcn.2012.126. Epub 2012 Sep 19. Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteri NCIMB 30242: a randomized controlled trial.

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Fecal Gluten Peptides Reveal Limitations of Serological Tests and Food Questionnaires for Monitoring Gluten-Free Diet in Celiac Disease Patients

The American Journal of Gastroenterology, volume111,1456–65 (2016).

Comparison of Clinical Methods with the Faecal Gluten Immunogenic Peptide to Assess Gluten Intake in Coeliac Disease. Gerasimidis, Konstantinos et al.

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Underdiagnosis of Dementia: an Observational Study of Patterns in Diagnosis and Awareness in US Older Adults

Occult blood in faeces is associated with all-cause and non-colorectal cancer mortalityGut, 2018; gutjnl-2018-316483 DOI: 10.1136/gutjnl-2018-316483

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Using citizen science to describe the prevalence and distribution of tick bite and exposure to tick-borne diseases in the United StatesPLOS ONE, 2018; 13 (7): e0199644 DOI: 10.1371/journal.pone.0199644

Dietary flavonoids and the prevalence and 15-y incidence of age-related macular degeneration. American Journal of Clinical Nutrition, 2018 DOI: 10.1093/ajcn/nqy114

Effects of an Antioxidant-enriched Multivitamin in Cystic Fibrosis: Randomized, Controlled, Multicenter Trial. American Journal of Respiratory and Critical Care Medicine, 2018; DOI: 10.1164/rccm.201801-0105OC

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Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: A pilot study. Nutrition and Healthy Aging, 2018; 4 (4): 345 DOI: 10.3233/NHA-170036


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affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study. Journal of Affective Disorders, May 2018, 232, 349–357.


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Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces. Nature Immunology, 2016; DOI: 10.1038/ni.3345


Miguel’s food challenge:

Harnessing the Power of Microbiome Assessment Tools as Part of Neuroprotective Nutrition and Lifestyle Medicine Interventions
by Miguel Toribio-Mateas. Microorganisms 2018, 6(2), 35;

American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems. 2018 May 15;3(3). pii: e00031-18. doi: 10.1128/mSystems.00031-18. eCollection 2018 May-Jun.

Martin, C. M. and Felix-Bortolotti, M. (2010) ‘W(h)ither complexity? The emperor’s new toolkit? Or elucidating the evolution of health systems knowledge?’, J Eval Clin
Pract, 16(3), pp. 415-20.

Daniel McDonald et al. American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems, 2018; 3 (3): e00031-18 DOI: 10.1128/mSystems.00031-18

Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth.
Probiotics Antimicrob Proteins. 2018 Mar 5. doi: 10.1007/s12602-018-9401-3. [Epub ahead of print]


CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system—New mode of action for caffeine. PLOS Biology, 2018; 16 (6): e2004408 DOI: 10.1371/journal.pbio.2004408

Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus. Neuron, 2018; DOI: 10.1016/j.neuron.2018.05.023

June 2018


Mediterranean diet and 3-year Alzheimer brain biomarker changes in middle-aged adults. Neurology. Online April 13, 2018, DOI:

Lifestyle and vascular risk effects on MRI-based biomarkers of Alzheimer’s disease: a cross-sectional study of middle-aged adults from the broader New York City area. BMJ Open. 2018 Mar 23;8(3):e019362. doi: 10.1136/bmjopen-2017-019362.

Counting the Cost:

Bernie Sanders opioid bill:

BEN BROWN – IBD interventions

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  40. Chassaing B, et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 2015 Mar 5;519(7541):92-6
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  42. Roberts CL, Keita AV, Duncan SH, et al. Translocation of Crohn’s disease Escherichia coli across M-cells: contrasting effects of soluble plant fibres and emulsifiers. Gut 2010;59:1331–9.
  43. Martino JV, Van Limbergen J, Cahill LE. The role of carrageenan and carboxymethyl cellulose in the development of intestinal inflammation. Front Pediatr 2017;(5):96.
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  45. Rodriguez-Palacios A, Harding A, Menghini P, et al. The Artificial Sweetener Splenda Promotes Gut Proteobacteria, Dysbiosis, and Myeloperoxidase Reactivity in Crohn’s Disease-Like Ileitis. Inflamm Bowel Dis. 2018 Mar 15. doi: 10.1093/ibd/izy060. [Epub ahead of  print]
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1. ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury. The American Journal of Gastroenterology, 2014; DOI: 10.1038/ajg.2014.131.
Bonkovsky also quoted in “When Green Tea Is a Bad Thing”, by Charlotte Hilton Andersen, SHAPE:
2. Determination of Catechin and Epicatechin Content in Chocolates by High-Performance Liquid Chromatography. Int Sch Res Notices. 2014; 2014: 628196. Published online 2014 Oct 28. doi:  10.1155/2014/628196.

  1. Green Tea Catechins and Cardiovascular Health: An Update. Curr Med Chem. 2008; 15(18): 1840–1850. Pon Velayutham, Anandh Babu, and Dongmin Liu.
  2. Suppressive Effects of Tea Catechins on Breast Cancer. Nutrients. 2016 Aug; 8(8): 458. Published online 2016 Jul 28. doi:  10.3390/nu8080458
  3. Green Tea Polyphenols Stimulate Mitochondrial Biogenesis and Improve Renal Function after Chronic Cyclosporin A Treatment in Rats. PLoS One. 2013; 8(6): e65029.

Published online 2013 Jun 3. doi:  10.1371/journal.pone.0065029

Blueberry Supplementation Influences the Gut Microbiota, Inflammation, and Insulin Resistance in High-Fat-Diet-Fed Rats. J Nutr. 2018 Feb 1;148(2):209-219. doi: 10.1093/jn/nxx027.

Diet-driven microbiota dysbiosis is associated with vagal remodeling and obesity. Physiology & Behavior, 2017; 173: 305 DOI: 10.1016/j.physbeh.2017.02.027

Oral NaHCO3 Activates a Splenic Anti-Inflammatory Pathway: Evidence That Cholinergic Signals Are Transmitted via Mesothelial Cells. The Journal of Immunology, 2018; ji1701605 DOI: 10.4049/jimmunol.1701605

Wax Esters from the Marine Copepod Calanus finmarchicus Reduce Diet-Induced Obesity and Obesity-Related Metabolic Disorders in Mice. J Nutr, 2013, doi: 10.3945/jn.113.182501.
Oil from the marine zooplankton Calanus finmarchicus improves the cardiometabolic phenotype of diet-induced obese mice. British Journal of Nutrition 2013, 110 (12): 2186-93.

Wax Esters from the Marine Copepod Calanus finmarchicus Reduce Diet-Induced Obesity and Obesity-Related Metabolic Disorders in Mice. J Nutr 2014, 144 (2): 164-169.

Extract from the Marine Copepod Calanus finmarchicus Attenuates Atherogenesis in Female Apolipoprotein E-Deficient Mice. J Nutr 2012, 142: 508-512.
Dietary and pharmacological anti-obesogenic treatments improve myocardial metabolism in diet-induced obese mice. Poster presented at 2017 Annual Scientific Sessions, Society for Heart and Vascular Metabolism. P2.11.


  1. Mushrooms: A rich source of the antioxidants ergothioneine and glutathione. Michael D. Kalaras, John P. Richie, Ana Calcagnotto, Robert B. Beelman.  Food Chemistry, 2017; 233: 429 DOI: 10.1016/j.foodchem.2017.04.109
  2. The Complexity of Fungal β-Glucan in Health and Disease: Effects on the Mononuclear Phagocyte System. Camilli G, Tabouret G, Quintin J. Front Immunol.2018 Apr 16;9:673. doi: 10.3389/fimmu.2018.00673. eCollection 2018.
  3. Anti-inflammatory properties of the medicinal mushroom Cordyceps militaris might be related to its linear (1→3)-β-D-glucan. PLoS One.2014 Oct 17;9(10):e110266. doi: 10.1371/journal.pone.0110266. eCollection 2014.
    4. β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance. Cell, 2016; 167 (5): 1354 DOI: 10.1016/j.cell.2016.09.034
  5. Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation. J Diet Suppl.2016 Jul 13:1-13. [Epub ahead of print]
  6. Edible and Medicinal Mushrooms: Emerging Brain Food for the Mitigation of Neurodegenerative Diseases. Journal of Medicinal FoodVOL. 20, NO. 1 |

Published Online: 1 Jan 2017

  1. Article online at MRL’s website:

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging. Cell Stem Cell, 2018; 22 (5): 769 DOI: 10.1016/j.stem.2018.04.001.

Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells. Cell Metab. 2016 Apr 12;23(4):663-74. doi: 10.1016/j.cmet.2016.03.001. Epub 2016 Mar 31.

Natural polyphenols as sirtuin 6 modulators. Scientific Reports, 2018; 8 (1) DOI: 10.1038/s41598-018-22388-5.

Inactive Matrix Gla Protein, Arterial Stiffness, and Endothelial Function in African American Hemodialysis Patients. American Journal of Hypertension, 2018; 31 (6): 735 DOI: 10.1093/ajh/hpy049.

Effect of a high-egg diet on cardiometabolic risk factors in people with type 2 diabetes: the Diabetes and Egg (DIABEGG) Study—randomized weight-loss and follow-up phase.  American J of Clinical Nutrition, 2018; DOI: 10.1093/ajcn/nqy048

Microglial control of astrocytes in response to microbial metabolites. Nature, 2018; DOI: 10.1038/s41586-018-0119-x

The mycobiome: Role in health and disease, and as a potential probiotic target in gastrointestinal disease. Dig Liver Dis. 2017 Nov;49(11):1171-1176. doi: 10.1016/j.dld.2017.08.025. Epub 2017 Oct 4.

Vitamin D Switches BAF Complexes to Protect β Cells. Cell, 2018; DOI: 10.1016/j.cell.2018.04.013.

May 2018

JAMA Intern Med. 2018 Jan 1;178(1):17-26. doi: 10.1001/jamainternmed.2017.5038.

Association Between Pesticide Residue Intake From Consumption of Fruits and Vegetables and Pregnancy Outcomes Among Women Undergoing Infertility Treatment With Assisted Reproductive Technology.

Chiu YH1,2Williams PL2,3Gillman MW4,5Gaskins AJ1,6Mínguez-Alarcón L7Souter I8Toth TL8Ford JB7Hauser R2,7,8Chavarro JE1,2,6EARTH Study Team.

Hum Reprod. 2015 Jun;30(6):1342-51. doi: 10.1093/humrep/dev064. Epub 2015 Mar 30. Fruit and vegetable intake and their pesticide residues in relation to semen quality among men from a fertility clinic.

Chiu YH1Afeiche MC2Gaskins AJ3Williams PL4Petrozza JC5Tanrikut C6Hauser R7Chavarro JE8.

CNN Exclusive: “The more opioids doctors prescribe, the more money they make”

Story by Aaron KesslerElizabeth Cohen and Katherine Grise. Updated 8:45 AM ET, Mon March 12, 2018:

Jonathan C Hill, David GT Whitehurst, Martyn Lewis, Stirling Bryan, Kate M Dunn, Nadine E Foster, Kika Konstantinou, Chris J Main, Elizabeth Mason, Simon Somerville, Gail Sowden, Kanchan Vohora, Elaine M Hay. Comparison of stratified primary care management for low back pain with current best practice (STarT Back): a randomised controlled trial. The Lancet, 2011; 378 (9802): 1560 DOI: 10.1016/S0140-6736(11)60937-9

What low back pain is and why we need to pay attention. Jan Hartvigsen, Mark J Hancock, Alice Kongsted, Quinette Louw, Manuela L Ferreira, Stéphane Genevay, Damian Hoy, Jaro Karppinen, Glenn Pransky, Joachim Sieper, Rob J Smeets, Martin Underwood on behalf of the Lancet Low Back Pain Series Working Group

The Lancet, March 21, 2018.

Eva Benito, Cemil Kerimoglu, Binu Ramachandran, Tonatiuh Pena-Centeno, Gaurav Jain, Roman Manuel Stilling, Md Rezaul Islam, Vincenzo Capece, Qihui Zhou, Dieter Edbauer, Camin Dean, André Fischer. RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental EnrichmentCell Reports, 2018; 23 (2): 546 DOI: 10.1016/j.celrep.2018.03.059.


  1. Redman, L.M., et al., Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging. Cell Metab, 2018.
  2. Williams, D.S., et al., Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Aging Cell, 2009. 8(6): p. 765-8.
  3. Edwards, C.B., et al., Malate and Fumarate Extend Lifespan in Caenorhabditis elegans. PLoS One, 2013. 8(3): p. e58345.
  4. Nogueira, L., Acute Oxaloacetate Exposure Enhances Resistance to Fatigue in in vitro Mouse Soleus Muscle. FASEB Journal, 2011. 25(1104.5).

Christopher R. Martens, Blair A. Denman, Melissa R. Mazzo, Michael L. Armstrong,

Nichole Reisdorph, Matthew B. Mcqueen, Michel Chonchol, Douglas R. Seals. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD in healthy middle-aged and older adultsNature Communications, 2018; DOI: 10.1038/s41467-018-03421-7.

Hypertension – BEN BROWN

  1. Appel LJ, Brands MW, Daniels SR, Karanja N, Elmer PJ, Sacks FM; American Heart Association. Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association. Hypertension. 2006 Feb;47(2):296-308.
  2. Schwingshackl L, Schwedhelm C, Hoffmann G, Knüppel S, Iqbal K, Andriolo V, Bechthold A, Schlesinger S, Boeing H. Food Groups and Risk of Hypertension: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies. Adv Nutr. 2017 Nov 15;8(6):793-803.
  3. Lennon SL, DellaValle DM, Rodder SG, Prest M, Sinley RC, Hoy MK, Papoutsakis C. 2015 Evidence Analysis Library Evidence-Based Nutrition Practice Guideline for the Management of Hypertension in Adults. J Acad Nutr Diet. 2017 Sep;117(9):1445-1458.e17.
  4. Ndanuko RN, Tapsell LC, Charlton KE, Neale EP, Batterham MJ. Dietary Patterns  and Blood Pressure in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Adv Nutr. 2016 Jan 15;7(1):76-89.
  5. Champagne CM. Dietary interventions on blood pressure: the Dietary Approaches  to Stop Hypertension (DASH) trials. Nutr Rev. 2006 Feb;64(2 Pt 2):S53-6.
  6. Appel LJ, Moore TJ, Obarzanek E, et al. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med. 1997 Apr 17;336(16):1117-24.
  7. Saneei P, Salehi-Abargouei A, Esmaillzadeh A, Azadbakht L. Influence of Dietary Approaches to Stop Hypertension (DASH) diet on blood pressure: a systematic review and meta-analysis on randomized controlled trials. Nutr Metab Cardiovasc Dis. 2014 Dec;24(12):1253-61.
  8. Gay HC, Rao SG, Vaccarino V, Ali MK. Effects of Different Dietary Interventions on Blood Pressure: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Hypertension. 2016 Apr;67(4):733-9.
  9. Siervo M, Lara J, Chowdhury S, Ashor A, Oggioni C, Mathers JC. Effects of the  Dietary Approach to Stop Hypertension (DASH) diet on cardiovascular risk factors: a systematic review and meta-analysis. Br J Nutr. 2015 Jan 14;113(1):1-15.
  10. Salehi-Abargouei A, Maghsoudi Z, Shirani F, Azadbakht L. Effects of Dietary Approaches to Stop Hypertension (DASH)-style diet on fatal or nonfatal cardiovascular diseases–incidence: a systematic review and meta-analysis on observational prospective studies. Nutrition. 2013 Apr;29(4):611-8.
  11. Tuso P, Stoll SR, Li WW. A plant-based diet, atherogenesis, and coronary artery disease prevention. Perm J. 2015 Winter;19(1):62-7.
  12. Yokoyama Y, Nishimura K, Barnard ND, Takegami M, Watanabe M, Sekikawa A, Okamura T, Miyamoto Y. Vegetarian diets and blood pressure: a meta-analysis. JAMA Intern Med. 2014 Apr;174(4):577-87.
  13. Mozaffarian D, Fahimi S, Singh GM, et al. Global sodium consumption and death from cardiovascular causes. N Engl J Med 2014;371(7):624–34.
  14. Anderson CA, Johnson RK, Kris-Etherton PM, Miller EA. Commentary on Making Sense of the Science of Sodium. Nutr Today. 2015 Mar;50(2):66-71.
  15. Heaney RP. Making Sense of the Science of Sodium. Nutr Today. 2015 Mar;50(2):63-66.
  16. Rexhaj E, Messerli FH, Cerny D, Bohlender J. Salt and Blood Pressure: Cutting Through the Scientific Fog. Curr Hypertens Rep. 2017 Jun;19(6):47.
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CONSULTATION – Garner Thomson

1. Beckman HB, Frankel RM (1984) The effect of physician behavior on the collection of data. Annals of Internal Medicine 101:692-6

2. Marvel MK (1999) Soliciting the patient’s agenda: have we improved? JAMA; 281: 283–7.


3. Svab I (1993) The time used by the patient when he/she talks without interruptions. Aten Primaria; 11: 175–7


4. Little M (1995) Humane Medicine. Cambridge:Cambridge University Press


5. Thomson G, Khan K (2016) Magic in Practice, London:Hammersmith Health Books


6.Hagger, M. S., Koch, S., Chatzisarantis, N. L. D., & Orbell, S. (2017). The common sense model of self-regulation: Meta-analysis and test of a process model. Psychological Bulletin, 143(11), 1117-1154.



Hetland G, Johnson E, Lyberg T, Kvalheim G (2011) The mushroom AgaricusblazeiMurill elicits medicinal effects on tumor, infection, allergy, and inflammation through its modulation of innate immunity and amelioration of Th1/Th2 imbalance and inflammation. Advances in PharmacologicalSciences, Article ID 157015.

Kohda H, Tokumoto W, Sakamoto K, Fujii M, Hirai Y, Yamasaki K, Komoda Y, Nakamura H, Ishihara S, Uchida M (1985). The biologically active constituents of Ganodermalucidum (Fr.) Karst histamine release-inhibitory triterpenes. Chemical and PharmaceuticalBulletin 33, 1367-1374.

Powell M (2006) The use of Ganodermalucidum (Reishi) in the management of histamine-mediated allergic responses Townsend Letter. TheExaminer of Alternative Medicine 274, 26-30

Takimoto H, Kato H, Kaneko M, Kumazawa Y (2008) Amelioration of skewed Th1/Th2 balance in tumor-bearing and asthma-induced mice by oral administration of Agaricusblazei extracts. Immunopharmacology and Immunotoxicology 30, 747-760

Tasaka K, Akagi M, Miyoshi K, Mio M, Makino T (1988a) Anti-allergic constituents in the culture medium of Ganodermalucidum. (I) Inhibitory effect of oleic acid on histamine release. Agents Actions 23,153-156

Tasaka K, Mio M, Izushi K, Akagi M, Makino T (1988b) Anti-allergic constituents in the culture medium of Ganodermalucidum. (II) The inhibitory effect of cyclooctasulfur on histamine release. Agents Actions 23, 157-160

Milica Vukmanovic-Stejic, Emma S. Chambers, Mayte Suárez-Fariñas, Daisy Sandhu, Judilyn Fuentes-Duculan, Neil Patel, Elaine Agius, Katie E. Lacy, Carolin T. Turner, Anis Larbi, Veronique Birault, Mahdad Noursadeghi, Neil A. Mabbott, Malcolm H.A. Rustin, James G. Krueger, Arne N. Akbar. Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase–induced inflammationJournal of Allergy and Clinical Immunology, 2017; DOI: 10.1016/j.jaci.2017.10.032


Leanne M. Redman, Steven R. Smith, Jeffrey H. Burton, Corby K. Martin, Dora Il’yasova, Eric Ravussin. Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of AgingCell Metabolism, 2018; DOI: 10.1016/j.cmet.2018.02.019

  1. Parvez, R. R. Gerona, C. Proctor, M. Friesen, J. L. Ashby, J. L. Reiter, Z. Lui, P. D. Winchester. Glyphosate exposure in pregnancy and shortened gestational length: a prospective Indiana birth cohort studyEnvironmental Health, 2018; 17 (1) DOI: 10.1186/s12940-018-0367-0

Erzsebet Polyak, Julian Ostrovsky, Min Peng, Stephen D. Dingley, Mai Tsukikawa, Young Joon Kwon, Shana E. McCormack, Michael Bennett, Rui Xiao, Christoph Seiler, Zhe Zhang, Marni J. Falk. N -acetylcysteine and vitamin E rescue animal longevity and cellular oxidative stress in pre-clinical models of mitochondrial complex I disease. Molecular Genetics and Metabolism, 2018; DOI: 10.1016/j.ymgme.2018.02.013

Eneida Boteon Schmitt, Jorge Nahas-Neto, Flavia Bueloni-Dias, Priscila Ferreira Poloni, Claudio Lera Orsatti, Eliana Aguiar Petri Nahas. Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women. Maturitas, 2018; 107: 97 DOI: 10.1016/j.maturitas.2017.10.011

Smruti Pushalkar, Mautin Hundeyin, Donnele Daley, Constantinos P. Zambirinis, Emma Kurz, Ankita Mishra, Navyatha Mohan, Berk Aykut, Mykhaylo Usyk, Luisana E. Torres, Gregor Werba, Kevin Zhang, Yuqi Guo, Qianhao Li, Neha Akkad, Sarah Lall, Benjamin Wadowski, Johana Gutierrez, Juan Andres Kochen Rossi, Jeremy W. Herzog, Brian Diskin, Alejandro Torres-Hernandez, Josh Leinwand, Wei Wang, Pardeep S. Taunk, Shivraj Savadkar, Malvin Janal, Anjana Saxena, Xin Li, Deirdre Cohen, R. Balfour Sartor, Deepak Saxena, George Miller. The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune SuppressionCancer Discovery, 2018; DOI: 10.1158/2159-8290.CD-17-1134

Brandon H Hidaka, Jocelynn M Thodosoff, Elizabeth H Kerling, Holly R Hull, John Colombo, Susan E Carlson. Intrauterine DHA exposure and child body composition at 5 y: exploratory analysis of a randomized controlled trial of prenatal DHA supplementation. The American Journal of Clinical Nutrition, 2018; 107 (1): 35 DOI: 10.1093/ajcn/nqx007

Current Opinion in Food Science, Volume 20, April 2018, Pages 19-23. CYP7A1-rs3808607: a single nucleotide polymorphism associated with cholesterol response to functional foods YongboShe12Dylan SMacKay23James DHouse2Peter JHJones.

COMMENT by Dr Eve Pearce:

Abdullah, M. M., Cyr, A., Lépine, M.-C., Eck, P. K., Couture, P., Lamarche, B., & Jones, P. J. (2016). Common Variants in Cholesterol Synthesis– and Transport–Related Genes Associate with Circulating Cholesterol Responses to Intakes of Conventional Dairy Products in Healthy Individuals. The Journal of Nutrition, 146(5), 1008–1016.

De Castro-Orós, I., Pampín, S., Cofán, M., Mozas, P., Pintó, X., Salas-Salvadó, J., … Pocoví, M. (2011). Promoter variant −204A > C of the cholesterol 7α-hydroxylase gene: Association with response to plant sterols in humans and increased transcriptional activity in transfected HepG2 cells. Clinical Nutrition, 30(2), 239–246.

Jenkins, D. J. A., Kendall, C. W. C., Faulkner, D., Vidgen, E., Trautwein, E. A., Parker, T. L., … Connelly, P. W. (2002). A dietary portfolio approach to cholesterol reduction: combined effects of plant sterols, vegetable proteins, and viscous fibers in hypercholesterolemia. Metabolism: Clinical and Experimental, 51(12), 1596–604.

Juzyszyn, Z., Kurzawski, M., Lener, A., Modrzejewski, A., Pawlik, A., & Droździk, M. (2008). Cholesterol 7α-Hydrolase ( CYP7A1 ) c.−278A>C Promoter Polymorphism in Gallstone Disease Patients. Genetic Testing, 12(1), 97–100.

MacKay, D. S., Eck, P. K., Gebauer, S. K., Baer, D. J., & Jones, P. J. (2015). CYP7A1-rs3808607 and APOE isoform associate with LDL cholesterol lowering after plant sterol consumption in a randomized clinical trial. The American Journal of Clinical Nutrition, 102(4), 951–957.

Rideout, T. C., Harding, S. V, & Mackay, D. S. (2012). Metabolic and genetic factors modulating subject specific LDL-C responses to plant sterol therapy. Canadian Journal of Physiology and Pharmacology, 90(5), 509–14.

Russell, D. W. (2003). The enzymes, regulation, and genetics of bile acid synthesis. Annual Review of Biochemistry, 72(1), 137–74.

She, Y., MacKay, D. S., House, J. D., & Jones, P. J. (2018). CYP7A1-rs3808607: a single nucleotide polymorphism associated with cholesterol response to functional foods. Current Opinion in Food Science, 20, 19–23.




March 2018

IHCAN March references


Fiolet Thibault, Srour Bernard, Sellem Laury, Kesse-Guyot Emmanuelle, Allès Benjamin, Méjean Caroline et al. Consumption of ultra-processed foods and cancer risk: results from NutriNet-Santé prospective cohort. BMJ 2018; 360 :k322.

Yumi Hurst, Haruhisa Fukuda. Effects of changes in eating speed on obesity in patients with diabetes: a secondary analysis of longitudinal health check-up data. BMJ Open, 2018; 8 (1): e019589 DOI: 10.1136/bmjopen-2017-019589.

Christopher D. Gardner, John F. Trepanowski, Liana C. Del Gobbo, Michelle E. Hauser, Joseph Rigdon, John P. A. Ioannidis, Manisha Desai, Abby C. King. Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical TrialJAMA, 2018; 319 (7): 667-679 DOI: 10.1001/jama.2018.0245.

Adelaida Esteban-Fernández, Irene Zorraquín-Peña, Maria D. Ferrer, Alex Mira, Begoña Bartolomé, Dolores González de Llano, M. Victoria Moreno-Arribas. Inhibition of Oral Pathogens Adhesion to Human Gingival Fibroblasts by Wine Polyphenols Alone and in Combination with an Oral ProbioticJournal of Agricultural and Food Chemistry, 2018; DOI: 10.1021/acs.jafc.7b05466


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MUSHROOM NUTRITION1             American Chemical Society (2000, May 12). New Evidence Found Linking Herpes and Alzheimer’s. Science Daily. Retrieved July 26, 2013, from http://             University of Manchester (2008, December 7). Cold Sore Virus Linked To Alzheimer’s Disease: New Treatment, Or Even Vaccine Possible. Science- Daily. Retrieved July 26, 2013, from /releas- es/2008/12/081207134109.htm3             MA Wozniak, AP Mee and RF Itzhaki. Herpes simplex virus type I DNA is located within Alzheimer’s disease amyloid plaques. The Journal of Pathology, Volume 217, Issue 1 , Pages131 – 138 2009 DOI: 10.1002/path.24494             Carter CJ. Alzheimer´s disease plaques and tangles:cemeteries of phyrrhic victory of the immune defence network against herpes simplex infection at the expense of complement and inflammation-mediated neuronal destruction.Neurochem Int. 2011 Feb 58(3):301-20 doi 10 1016/j.neuint 2010.12.20.003Epub 2010 Dec 15.5             Wozniak MA, Frost AL, Preston CM, Itzhaki RF.  Antivirals reduce the forma- tion of key Alzheimer´s disease molecules in cell cultures acutely infected with herpes simplex virus type 1. PLoS One. 2011:6(10) e25152 doi 10 1371/ journal. pone.0025152. EPUB 2011 Oct 7.6             Pandley JP. Immunoglobulin GM genese as functional risk and protective fac- tors for the development of Alzheimer´s disease. J. Alzheimers Dis 2009;17(4) 753-6 doi 10.3222/JAD-2009-1094.7             Wozniak MA, Itzhaki RF. Intravenous immounoglobulin reduces amyloid and abnormal tau formation caused by herpes simplex virus type 1. J Neuroimmunol 2013 Apr 15:257 (1-2):7-12 doi 10. 1016/ jnmeuroim 2013.01.005 Epub 2013Feb 4.8             Medeiros R, Kitazawa M, Passos GF, Baglietto-Vargas D, Cheng D, Cribbs  OH, LaFerla FM. Aspirin-triggered  lipoxin  A4  stimulates  alternative  activation of microglia and reduces Alzheimer disease-like pathology in mice. Am J Pathol. 2013 May, 182(5);1740-9 ..9             Jean A. Monro, Chronic Fatigue Immune Dysfunction Syndrome. J Integrative Medicine 2004; 8:101-10810           Jean A. Monro. Treatment of Cancer with Mushroom Products. Arch Env Health 2003;58:533-537.11           Silva Couto J, Pereira da Silva D. Evaluation of the Efficacy of Coriolus versicolor Supplementation in HPV Lesions (LSIL) . Poster presented at the 20th European Congress of Obstetrics and Gynecology, Lisbon, Portugal March4-8th, 2008.12           Cornelius C. , Cavallaro M., Cambria M.T., Toscano M.A., Calabrese V. Com- parative Enzyme Analysis of Polyporus umbellatus, Agaricus blazei, Pleurotus osteratus and Hericium erinaceus . Clinical Journal of Mycology 2009 Vol II Page 4 to 7.13           Kulmann I, Minihane Am, Huebbe P, Nebel A , Rimbach G. Apolipoprotien  E genotype and hepatitis c, HIV and herpes simplex diseae risk: a literature review. Lipids Health Dis. 2010 Jan 28.9.8 doi 10.1186/1476-511-9.614           Miklossy J. Emerging roles of pathogens in Alzheimer disease. Expert Rev Mol Med. 2011 Sept 20; 13 e 30 doi 10 1017/S14623994 1 1002006.  Also relevant:
Calabrese, V. Fernandes, T. Excerpt from Clinical Journal of Mycology Vol IV, Pages 10-12, Nov 2013, Aneid Press.
Trovato A, et al. Redox modulation of cellular stress response and lipoxin A4 expression by Coriolus versicolor in rat brain: Relevance to Alzheimer’s disease pathogenesis. Neurotoxicology (2015): j.neuro.2015.09.012.

Trovato et al. Redox modulation of cellular stress response and lipoxin A4 expression byHericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis. Immunity & Ageing (2016) 13:23.  DOI 10.1186/s12979-016-0078-8. Coriolus versicolor biomass increases dendritic arborization of newly-generated neurons in mouse hippocampal dentate gyrus. Elisabete Ferreiro, Inês Pita, Nuno R. Ferreira , Carlos A Fontes-Ribeiro , Frederico C. Pereira , A. Cristina Rego. Abstract  presented February 5, 2018, at the 48th Annual Meeting of the Portuguese Society of Pharmacology, at the University of Lisbon.

Attia Anwar, Provvidenza Maria Abruzzo, Sabah Pasha, Kashif Rajpoot, Alessandra Bolotta, Alessandro Ghezzo, Marina Marini, Annio Posar, Paola Visconti, Paul J. Thornalley, Naila Rabbani. Advanced glycation endproducts, dityrosine and arginine transporter dysfunction in autism – a source of biomarkers for clinical diagnosisMolecular Autism, 2018; 9 (1) DOI: 10.1186/s13229-017-0183-3.


Kathleen F. Holton, Peter K. Ndege, Daniel J. Clauw. Dietary correlates of chronic widespread pain in meru, KenyaNutrition, 2018; DOI: 10.1016/j.nut.2018.01.016.

Adil Mardinoglu, Hao Wu, Elias Bjornson, Cheng Zhang, Antti Hakkarainen, Sari M. Räsänen, Sunjae Lee, Rosellina M. Mancina, Mattias Bergentall, Kirsi H. Pietiläinen, Sanni Söderlund, Niina Matikainen, Marcus Ståhlman, Per-Olof Bergh, Martin Adiels, Brian D. Piening, Marit Granér, Nina Lundbom, Kevin J. Williams, Stefano Romeo, Jens Nielsen, Michael Snyder, Mathias Uhlén, Göran Bergström, Rosie Perkins, Hanns-Ulrich Marschall, Fredrik Bäckhed, Marja-Riitta Taskinen, Jan Borén. An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans. Cell Metabolism, 2018; DOI: 10.1016/j.cmet.2018.01.005.

Nicola McCleary, Bright I. Nwaru, Ulugbek B. Nurmatov, Hilary Critchley, Aziz Sheikh. Endogenous and exogenous sex steroid hormones in asthma and allergy in females: A systematic review and meta-analysisJournal of Allergy and Clinical Immunology, 2018; DOI: 10.1016/j.jaci.2017.11.034



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February 2018

Woodcock B A, Ridding L, Freeman S N, Pereira M G, Sleep D, Redhead J, et al. (2018) Neonicotinoid residues in UK honey despite European Union moratorium. DOI: 10.1371/journal.pone.0189681 (open access)

Katarina Ondrusova, Mohammad Fatehi, Amy Barr, Zofia Czarnecka, Wentong Long, Kunimasa Suzuki, Scott Campbell, Koenraad Philippaert, Matthew Hubert, Edward Tredget, Peter Kwan, Nicolas Touret, Martin Wabitsch, Kevin Y. Lee, Peter E. Light. Subcutaneous white adipocytes express a light sensitive signaling pathway mediated via a melanopsin/TRPC channel axisScientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-16689-4

Anas Raed, Jigar Bhagatwala, Haidong Zhu, Norman K. Pollock, Samip J. Parikh, Ying Huang, Robyn Havens, Ishita Kotak, De-Huang Guo, Yanbin Dong. Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial. PLOS ONE, 2017; 12 (12): e0188424 DOI: 10.1371/journal.pone.0188424


Infectious virus in exhaled breath of symptomatic seasonal influenza cases from a college community. PNAS 2018 ; published ahead of print January 18, 2018, doi:10.1073/pnas.1716561115. 

Enhanced aerobic exercise performance in women by a combination of three mineral Chelates plus two conditionally essential nutrients

Robert A. DiSilvestro et al. Journal of the International Society of Sports Nutrition 201714:42.


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Kourosh Kalantar-Zadeh, Kyle J. Berean, Nam Ha, Adam F. Chrimes, Kai Xu, Danilla Grando, Jian Zhen Ou, Naresh Pillai, Jos L. Campbell, Robert Brkljača, Kirstin M. Taylor, Rebecca E. Burgell, Chu K. Yao, Stephanie A. Ward, Chris S. McSweeney, Jane G. Muir, Peter R. Gibson. A human pilot trial of ingestible electronic capsules capable of sensing different gases in the gutNature Electronics, 2018; 1 (1): 79 DOI: 10.1038/s41928-017-0004-x.

Paleo diet: material supplied by Umeå universitet: – dissertation available there.

Stephen A. Fleming, Supida Monaikul, Alexander J. Patsavas, Rosaline V. Waworuntu, Brian M. Berg, Ryan N. Dilger. Dietary polydextrose and galactooligosaccharide increase exploratory behavior, improve recognition memory, and alter neurochemistry in the young pigNutritional Neuroscience, 2017; 1 DOI: 10.1080/1028415X.2017.1415280.

Giuseppe Faraco, David Brea, Lidia Garcia-Bonilla, Gang Wang, Gianfranco Racchumi, Haejoo Chang, Izaskun Buendia, Monica M. Santisteban, Steven G. Segarra, Kenzo Koizumi, Yukio Sugiyama, Michelle Murphy, Henning Voss, Joseph Anrather, Costantino Iadecola. Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 responseNature Neuroscience, 2018; DOI: 10.1038/s41593-017-0059-z

Salt stats:

Irina Leonardi et al. CX3CR1 mononuclear phagocytes control immunity to intestinal fungiScience, 2018 DOI: 10.1126/science.aao1503.

Sébastien Lucas, Yasunori Omata, Jörg Hofmann, Martin Böttcher, Aida Iljazovic, Kerstin Sarter, Olivia Albrecht, Oscar Schulz, Brenda Krishnacoumar, Gerhard Krönke, Martin Herrmann, Dimitrios Mougiakakos, Till Strowig, Georg Schett, Mario M. Zaiss. Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-017-02490-4


Yu-Jin Jung, Young-Tae Lee, Vu Le Ngo, Young-Hee Cho, Eun-Ju Ko, Sung-Moon Hong, Ki-Hye Kim, Ji-Hun Jang, Joon-Suk Oh, Min-Kyung Park, Cheol-Hyun Kim, Jun Sun, Sang-Moo Kang. Heat-killed Lactobacillus casei confers broad protection against influenza A virus primary infection and develops heterosubtypic immunity against future secondary infectionScientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-17487-8

Aura Raulo, Lasse Ruokolainen, Avery Lane, Katherine Amato, Rob Knight, Steven Leigh, Rebecca Stumpf, Bryan White, Karen E. Nelson, Andrea L. Baden, Stacey R. Tecot. Social behaviour and gut microbiota in red-bellied lemurs (Eulemur rubriventer): In search of the role of immunity in the evolution of socialityJournal of Animal Ecology, 2017; DOI: 10.1111/1365-2656.12781

Corticotropin-releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress-induced pathophysiology.

Ayyadurai S, Gibson AJ, D’Costa S, Overman EL, Sommerville LJ, Poopal AC, Mackey E, Li Y, Moeser AJ. J Leukoc Biol. 2017 Dec;102(6):1299-1312. doi: 10.1189/jlb.2HI0317-088RR.

Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide.

Gulledge TV1, Collette NM1, Mackey E2, Johnstone SE1, Moazami Y3, Todd DA4, Moeser AJ2, Pierce JG5, Cech NB4, Laster SM6. J Ethnopharmacol. 2018 Feb 15;212:166-174. doi: 10.1016/j.jep.2017.10.012. Epub 2017 Oct 14.

Evilena Anastasiou, Anastasia Papathanasiou, Lynne A. Schepartz, Piers D. Mitchell. Infectious disease in the ancient Aegean: Intestinal parasitic worms in the Neolithic to Roman Period inhabitants of Kea, GreeceJournal of Archaeological Science: Reports, 2017; DOI: 10.1016/j.jasrep.2017.11.006

Catherine Vilchèze, John Kim, William R. Jacobs. Vitamin C potentiates the killing of Mycobacterium tuberculosis by the first-line tuberculosis drugs isoniazid and rifampicin in miceAntimicrobial Agents and Chemotherapy, 2018; AAC.02165-17 DOI: 10.1128/AAC.02165-17

January 2018


Lean, Michael EJ et al. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. The Lancet, 5 December 2017. DOI:

Elisabetta Lauretti, Domenico Pratic�. Effect of canola oil consumption on memory, synapse and neuropathology in the triple transgenic mouse model of Alzheimer’s diseaseScientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-17373-3

Monica E. Embers, Nicole R. Hasenkampf, Mary B. Jacobs, Amanda C. Tardo, Lara A. Doyle-Meyers, Mario T. Philipp, Emir Hodzic. Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feedingPLOS ONE, 2017; 12 (12): e0189071 DOI: 10.1371/journal.pone.0189071

Nicholas A. Crossland, Xavier Alvarez, Monica E. Embers. Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Post-Treatment in Rhesus MacaquesThe American Journal of Pathology, 2017; DOI: 10.1016/j.ajpath.2017.11.005

J Public Health Policy. 2017 Nov 27. doi: 10.1057/s41271-017-0095-7. [Epub ahead of print]. Complexity and conflicts of interest statements: a case-study of emails exchanged between Coca-Cola and the principal investigators of the International Study of Childhood Obesity, Lifestyle and the Environment (ISCOLE).

Stuckler D1, Ruskin G2, McKee M3. Open Access:


Louisa E. Jeffery, Peter Henley, Nefisa Marium, Andrew Filer, David M. Sansom, Martin Hewison, Karim Raza. Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid jointJournal of Autoimmunity, 2017; DOI: 10.1016/j.jaut.2017.10.001

Shweta Khanna, Kumar Sagar Jaiswal, Bhawna Gupta. Managing Rheumatoid Arthritis with Dietary InterventionsFrontiers in Nutrition, 2017; 4 DOI: 10.3389/fnut.2017.00052

  1. Loukov, S. Karampatos, M.R. Maly, D.M.E. Bowdish. Monocyte activation is elevated in women with knee-osteoarthritis and associated with inflammation, BMI and painOsteoarthritis and Cartilage, 2017; DOI: 10.1016/j.joca.2017.10.018

Diddier Prada, Jia Zhong, Elena Colicino, Antonella Zanobetti, Joel Schwartz, Nicholas Dagincourt, Shona C Fang, Itai Kloog, Joseph M Zmuda, Michael Holick, Luis A Herrera, Lifang Hou, Francesca Dominici, Benedetta Bartali, Andrea A Baccarelli. Association of air particulate pollution with bone loss over time and bone fracture risk: analysis of data from two independent studiesThe Lancet Planetary Health, 2017; 1 (8): e337 DOI: 10.1016/S2542-5196(17)30136-5

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3503-3508. doi: 10.1073/pnas.1618545114. Epub 2017 Mar 13.

B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial.

Zhong J1, Karlsson O2,3, Wang G4, Li J5,6, Guo Y7, Lin X8, Zemplenyi M7, Sanchez-Guerra M9, Trevisi L10, Urch B11,12,13,14, Speck M11, Liang L7, Coull BA7, Koutrakis P10, Silverman F11,12,13,14, Gold DR10,15, Wu T5,6, Baccarelli AA16.

A.A. Macintosh et al. Prehistoric women’s manual labor exceeded that of athletes through the first 5500 years of farming in Central EuropeScience Advances, 2017 DOI: 10.1126/sciadv.aao3893


Omar Al Rifai, Jacqueline Chow, Julie Lacombe, Catherine Julien, Denis Faubert, Delia Susan-Resiga, Rachid Essalmani, John W.M. Creemers, Nabil G. Seidah, Mathieu Ferron. Proprotein convertase furin regulates osteocalcin and bone endocrine functionJournal of Clinical Investigation, 2017; 127 (11): 4104 DOI: 10.1172/JCI93437

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PMCID: PMC4611080. Yogurt drink fortified with menaquinone-7 improves vitamin K status in a healthy population

Marjo H. J. Knapen,1 Lavienja A. J. L. M. Braam,1 Kirsten J. Teunissen,1 Renate M. L. Zwijsen,2 Elke Theuwissen,1 andCees Vermeer1,*

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STRESS – Catalina Fernández de Ana Portela

1. Suzanne C. Segerstrom and Gregory E. Miller, Psychological Stress and the Human Immune System: A Meta-Analytic Study of 30 Years of Inquiry, Psychol Bull. Author manuscript; available in PMC Feb 7, 2006.
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NUTRIGENOMICS – Bernie Williams
I. Hara K et al., The Pro12Ala Polymorphism in PPAR𝛾2 may confer resistance to type 2 diabetes. Biochem Biophys. Res. Comm. (2000) 29:212-216
II. Stefan N. et al., Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 gene. Diabetes. (2001) 50:1143–1148
III. Vaquero AR et al. Using gene-network landscape to dissect genotype effects of TCF7L2 genetic variant on diabetes and cardiovascular risk. Physiol. Genomics. (2012) 44:903–14
IV. Shaffer S A et al. Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 gene polymorphisms. Diabetes. (2007)12: 2443-50
V. Grant S et al. Variant of Transcription factor 7-like 2 gene confers risk of type 2 diabetes. Nature. (2006) 38: 320-323
VI. Scheller J et al., The pro-and-anti-inflammatory properties of the cytokine interleukin-6. Biochim et Biophys Acta – Mol Cell Res. (2011) 1813:5 878-888
VII. Ligthart S et al., DNA methylation signatures of chronic low grade inflammation are associated with complex diseases. (2016) Genome Biology 17:255
VIII. Brustolin S et al., Genetics of homocysteine metabolism and associated disorders. Braz J Med Biol Res (2010) 43:1-7
IX. Lim U & Song M, Dietary and Lifestyle Factors of DNA methylation. Cancer Epigenetics (2012) 863:359-376
X. Bokor S et al., Single nucleotide polymorphism in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios. Journal of Lipid Research (2010) 51:2325-33.
XI. Vessby B et al,. Desaturation and elongation of Fatty acids and insulin action. Ann N Y Acad Sci. (2002) 967:183-95.
XII. Leffler D et al., Extraintestinal manifestations of coeliac disease. Nat. Rev. Gastroenterol.Hepatol. (2015) 12: 561-571
XIII. Monsuur et al., Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms. PLoS ONE. (2008) 3:e2270
XIV. Withoff S, et al., Understanding celiac disease by genomics. Trends in Genetics. (2016) 32:295-308.

FRONTIERS – Simon Mills
Aggarwal BB.(2004) Nuclear factor-kappaB: the enemy within. Cancer Cell 6(3): 203-208.
Barnard RJ, Aronson WJ. (2009) Benign prostatic hyperplasia: does lifestyle play a role? Phys Sportsmed 37(4): 141-146.
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Bone K, Mills S. (2013) Principles and Practice of Phytotherapy; 2nd Edition. Churchill Livingstone, Edinburgh
Capodice JL, Gorroochurn P, Cammack S et al. (2009) Zyflamend in men with high-grade prostatic intraepithelial neoplasia: results of a phase I clinical trial. J Soc Integr Oncol 7(2): 43-51.
Demark-Wahnefried W, Polascik TJ, George SL et al. (2008) Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery. Cancer Epidemiol Biomarkers Prev 17(12): 3577-3587.
Freedland SJ, Aronson WJ. (2009) Dietary intervention strategies to modulate prostate cancer risk and prognosis. Curr Opin Urol 19(3): 263-267.
Gardner CD, Oelrich B, Liu JP et al. (2009) Prostatic soy isoflavone concentrations exceed serum levels after dietary supplementation. Prostate 69(7): 719-726.
Jacobs EJ, Rodriguez C, Mondul AM et al. (2005) A large cohort study of aspirin and other nonsteroidal anti-inflammatory drugs and prostate cancer incidence. J Natl Cancer Inst 97(13): 975-980.
John H, Barghorn A, Funke G et al. (2001) Noninflammatory chronic pelvic pain syndrome: immunological study in blood, ejaculate and prostate tissue. Eur Urol 39(1): 72-78.
Kell JS. (2010) Prostate-specific antigen tests and prostate cancer screening: an update for primary care physicians. Can J Urol 17(Suppl 1): 18-25.
Kramer G, Mitteregger D, Marberger M (2007). Is benign prostatic hyperplasia (BPH) an immune inflammatory disease? Eur Urol 51(5): 1202-1216.
Krieger JN. (2004) Classification, epidemiology and implications of chronic prostatitis in North America, Europe and Asia. Minerva Urol Nefrol 56(2): 99-107.
McCann MJ, Gill CI, Linton T et al. (2008) Enterolactone restricts the proliferation of the LNCaP human prostate cancer cell line in vitro. Mol Nutr Food Res 52(5): 567-580.
Mehik A, Hellstrom P, Sarpola A et al. (2001) Fears, sexual disturbances and personality features in men with prostatitis: a population-based cross-sectional study in Finland. BJU Int 88(1): g35-38.
Mills S. (2001) Benign prostatic disease: herbal approaches in Boyd & Hamilton-Stewart eds. Key advances in the effective management of benign prostatic disease. Journal of the Royal Society of Medicine, London. 35-40
Moul S, McVary KT. (2010) Lower urinary tract symptoms, obesity and the metabolic syndrome. Curr Opin Urol 20(1): 7-12.
Parsons JK, Im R. (2009) Alcohol consumption is associated with a decreased risk of benign prostatic hyperplasia. J Urol 182(4): 1463-1468.
Parsons JK, Sarma AV, McVary K et al. (2009) Obesity and benign prostatic hyperplasia: clinical connections, emerging etiological paradigms and future directions. J Urol 182(6 Suppl): S27-S31.
Parsons JK. (2007) Modifiable risk factors for benign prostatic hyperplasia and lower urinary tract symptoms: new approaches to old problems. J Urol 178(2): 395-401.
Patel AR, Klein EA. (2009) Risk factors for prostate cancer. Nat Clin Pract Urology 6(2): 87-95.
Ranjan P, Dalela D, Sankhwar SN. (2006) Diet and benign prostatic hyperplasia: implications for prevention. Urology 68(3): 470-476.
Roehrbornb CG (2008). Pathology of benign prostatic hyperplasia. Int J Impot Res 20(Suppl 3): S11-S18.
Safarinejad MR. (2005) Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. J Herbal Pharmacother 5(4): 1-11.
Sarma AV, Kellogg Parsons J. (2009) Diabetes and benign prostatic hyperplasia: emerging clinical connections. Curr Urol Rep 10(4): 267-275.
Sarma AV, Parsons JK, McVary K et al. (2009) Diabetes and benign prostatic hyperplasia/lower urinary tract symptoms-what do we know? J Urol 182(6 Suppl): S32-S37.
Schoonen WM, Salinas CA, Kiemeney LALM et al. (2005) Alcohol consumption and risk of prostate cancer in middle-aged men. Int J Cancer 113(1): 133-140.
Sciarra A, Mariotti G, Salciccia S et al. (2008) Prostate growth and inflammation. J Steroid Biochem Mol Biol 108(3-5): 254-260.
Sea J, Poon KS, McVary KT. (2009) Review of exercise and the risk of benign prostatic hyperplasia. Phys Sportsmed 37(4): 75-83.
Singh RP, Tyagi AK, Dhanalakshmi S et al. (2004) Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3. Int J Cancer 108(5): 733-740.
Tacklind J, MacDonald R, Rutks I, Wilt TJ. (2009) Serenoa repens for benign prostatic hyperplasia. Cochrane Database Syst Rev. CD001423.
Van Patten CL, de Boer JG, Tomlinson Guns ES. (2008) Diet and dietary supplement intervention trials for the prevention of prostate cancer recurrence: a review of the randomized controlled trial evidence. J Urol 180(6): 2314-2322.
Vikram A, Jena G, Ramarao P. (2010) Insulin-resistance and benign prostatic hyperplasia: the connection. Eur J Pharmacol 641(2-3): 75-81.
Wilt T, Ishani A, MacDonald R. (2002) Serenoa repens for benign prostatic hyperplasia. Cochrane Database Syst Rev CD001423.
Yan L, Spitznagel EL. (2009) Soy consumption and prostate cancer risk in men: a revisit of a meta-analysis. Am J Clin Nutr 89(4): 1155-1163.
Yassin AA, El-Sakka AI, Saad F et al. (2008) Lower urinary-tract symptoms and testosterone in elderly men. World J Urol 26(4): 359-364.

IN PRACTICE – Daniela Lawler.

Atkinson, W et al 2004. Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial. Gut, 53 Pp: 1391-1393.
Cantorna, M. Mahon, B. 2004. Mounting Evidence for Vitamin D as an Environmental Factor Affecting Autoimmune Disease Prevalence. EBM, 229(11).
Heitzer, T et al 2001. Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients with Coronary Artery Disease. Circulation, 104 Pp: 2673-2678. June 2017.
Hyde, J. (2015). The Gut Makeover. (Great Britain. Quercus).
Kharrazian, D (2010). Why Do I Still Have Thyroid Symptoms?. (California. Elephant Press) p25, 31.
Lewis, C. (2016). Enteroimmunology. 3rd ed (Carrabelle Florida. PsyPress), p246.
Liblau, R. 1995. Th1 and Th2 CD4+ T cells in the pathogenesis of organ specific autoimmune disease. Immunology Today, 16(1). Pp: 34-38.


Chunxu Gao, Bhanu Priya Ganesh, Zhongcheng Shi, Rajesh Rasik Shah, Robert Fultz, Angela Major, Susan Venable, Monica Lugo, Kathleen Hoch, Xiaowei Chen, Anthony Haag, Timothy C. Wang, James Versalovic. Gut Microbe–Mediated Suppression of Inflammation-Associated Colon Carcinogenesis by Luminal Histamine Production. The American Journal of Pathology, 2017; DOI: 10.1016/j.ajpath.2017.06.011

Lori D’Ortenzio, Isabelle Ribot, Bonnie Kahlon, Benoit Bertrand, Emmy Bocaege, Emeline Raguin, Annabelle Schattmann, Megan Brickley. The rachitic tooth: The use of radiographs as a screening technique. International Journal of Paleopathology, 2017; DOI: 10.1016/j.ijpp.2017.10.001

Haris Majeed, G. W. K. Moore. Impact of Multidecadal Climate Variability on United Kingdom Rickets Rates. Scientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-16058-1
Francesca Romana Mancini, Aurélie Affret, Courtney Dow, Beverley Balkau, Fabrice Bonnet, Marie-Christine Boutron-Ruault, Guy Fagherazzi. Dietary antioxidant capacity and risk of type 2 diabetes in the large prospective E3N-EPIC cohort. Diabetologia, 2017; DOI: 10.1007/s00125-017-4489-7

Nicola Wilck et al. Salt-responsive gut commensal modulates TH17 axis and disease. Nature, 2017; DOI: 10.1038/nature24628

November 2017

Joseph Jamnik, Christopher R Villa, Sirbarinder Bryn Dhir, David J A Jenkins, Ahmed El-Sohemy. Prevalence of positive coeliac disease serology and HLA risk genotypes in a multiethnic population of adults in Canada: a cross-sectional study. BMJ Open, 2017; 7 (10): bmjopen-2017-017678 DOI: 10.1136/bmjopen-2017-017678.

Luke T. Stewart, Anas U. Khan, Kai Wang, Diana Pizarro, Sandipan Pati, Susan C. Buckingham, Michelle L. Olsen, John C. Chatham, Lori L. McMahon. Acute Increases in Protein O-GlcNAcylation Dampen Epileptiform Activity in Hippocampus. The Journal of Neuroscience, 2017; 37 (34): 8207 DOI: 10.1523/JNEUROSCI.0173-16.2017.

Ken-ichi Kudo, Tadashi Hanafusa and Toshiro Ono.  In vitro analysis of radioprotective effect of monoterpenes. J Radioanal Nucl Chem (2017) 313: 169.

Laura M. Kemppainen, Teemu T. Kemppainen, Jutta A. Reippainen, Suvi T. Salmenniemi, Pia H. Vuolanto. Use of complementary and alternative medicine in Europe: Health-related and sociodemographic determinants. Scandinavian Journal of Public Health, 2017; 140349481773386 DOI: 10.1177/1403494817733869.

Olga Bednarska, Susanna A. Walter, Maite Casado-Bedmar, Magnus Ström, Eloísa Salvo-Romero, Maria Vicario, Emeran A. Mayer, Åsa V Keita. VIP and Mast Cells Regulate Increased Passage of Colonic Bacteria in Patients With Irritable Bowel Syndrome. Gastroenterology, 2017; DOI: 10.1053/j.gastro.2017.06.051

BEN BROWN – Nickel

1.             Schram SE, Warshaw EM, Laumann A. Nickel hypersensitivity: a clinical review and call to action. Int J Dermatol. 2010 Feb;49(2):115-25.2.             Yoshihisa Y, Shimizu T. Metal allergy and systemic contact dermatitis: an overview. Dermatol Res Pract. 2012;2012:749561.3.             Torres F, das Graças M, Melo M, Tosti A. Management of contact dermatitis due to nickel allergy: an update. Clin Cosmet Investig Dermatol. 2009 Apr 17;2:39-48.4.             Sharma AD. Relationship between nickel allergy and diet. Indian J Dermatol Venereol Leprol. 2007 Sep-Oct;73(5):307-12.5.             Jensen CS, Menné T, Lisby S, Kristiansen J, Veien NK. Experimental systemic contact dermatitis from nickel: a dose-response study. Contact Dermatitis. 2003 Sep;49(3):124-32.6.             Ysart G, Miller P, Crews H, Robb P, Baxter M, De L’Argy C, Lofthouse S, Sargent C, Harrison N. Dietary exposure estimates of 30 elements from the UK Total Diet Study. Food Addit Contam. 1999 Sep;16(9):391-403. 7.             Krecisz B, Chomiczewska D, Kiec-Swierczynska M, Kaszuba A. Systemic contact dermatitis to nickel present in cocoa in 14-year-old boy. Pediatr Dermatol. 2011 May-Jun;28(3):335-6. 8.             Silvestri DL, Barmettler S. Pruritus ani as a manifestation of systemic contact dermatitis: resolution with dietary nickel restriction. Dermatitis. 2011  Jan-Feb;22(1):50-5.

  1. Rizzi A, Nucera E, Laterza L, et al. Irritable Bowel Syndrome and Nickel Allergy: What Is the Role of the Low Nickel Diet? J Neurogastroenterol Motil. 2017 Jan 30;23(1):101-108.

10.         Sharma AD. Relationship between nickel allergy and diet. Indian J Dermatol Venereol Leprol. 2007 Sep-Oct;73(5):307-12.11.         Saito M, Arakaki R, Yamada A, Tsunematsu T, Kudo Y, Ishimaru N. Molecular Mechanisms of Nickel Allergy. Int J Mol Sci. 2016 Feb 2;17(2).12.         Minelli M, Schiavino D, Musca F, et al. Oral hyposensitization to nickel induces clinical improvement and a decrease in TH1 and TH2 cytokines in patients with systemic nickel allergy syndrome. Int J Immunopathol Pharmacol. 2010 Jan-Mar;23(1):193-201.

  1. Picarelli A, Di Tola M, Vallecoccia A, Libanori V, Magrelli M, Carlesimo M, et al. Oral mucosa patch test: a new tool to recognize and study the adverse effects of dietary nickel exposure. Biol Trace Elem Res 2011; 139: 151-9.

14.         Braga M, Quecchia C, Perotta C, Timpini A, Maccarinelli K, Di Tommaso L, Di Gioacchino M. Systemic nickel allergy syndrome: nosologic framework and usefulness of diet regimen for diagnosis. Int J Immunopathol Pharmacol. 2013 Jul-Sep;26(3):707-16.15.         Borghini R, Donato G, Alvaro D, Picarelli A. New insights in IBS-like disorders: Pandora’s box has been opened; a review. Gastroenterol Hepatol Bed Bench. 2017 Spring;10(2):79-89.

  1. Tammaro A, De Marco G, Persechino S, Narcisi A, Camplone G. Allergy to nickel: first results on patients administered with an oral hyposensitization therapy. Int J Immunopathol Pharmacol. 2009 Jul-Sep;22(3):837-40.


Roopa Hebbandi Nanjundappa, Francesca Ronchi, Jinguo Wang, Xavier Clemente-Casares, Jun Yamanouchi, Channakeshava Sokke Umeshappa, Yang Yang, Jesús Blanco, Helena Bassolas-Molina, Azucena Salas, Hamza Khan, Robyn M. Slattery, Madeleine Wyss, Catherine Mooser, Andrew J. Macpherson, Laura K. Sycuro, Pau Serra, Derek M. McKay, Kathy D. McCoy, Pere Santamaria. A Gut Microbial Mimic that Hijacks Diabetogenic Autoreactivity to Suppress Colitis. Cell, 2017; 171 (3): 655 DOI: 10.1016/j.cell.2017.09.022

Membrane Lipid Replacement – Mike Ash
[i] Nicolson GL, Ash ME.  Membrane Lipid Replacement for chronic illnesses, aging and cancer using oral glycerolphospholipid formulations with fructooligosaccharides to restore phospholipid function in cellular membranes, organelles, cells and tissues. Biochim. Biophys. Acta  2017; 1859: 1704-1724.  View Full Paper
[ii] Nicolson GL.  Membrane Lipid Replacement: clinical studies using a natural medicine approach to restoring membrane function and improving health.  Intern. J. Clin. Med. 2016; 7: 133-143. View Full Paper
[iii] Nicolson GL, Rosenblatt S, Ferreira de Mattos G, Settineri R, Breeding PC, Ellithorpe RR,  Ash ME.  Clinical uses of Membrane Lipid Replacement supplements in restoring membrane function and reducing fatigue in chronic diseases and cancer.  Discoveries 2016; 4(1): e54. View Full Paper
[iv] Singer, SJ, Nicolson GL The fluid mosaic model of the structure of cell membranes, Science 1972; 175: 720-731. View Abstract
[v] Nicolson GL. The Fluid—Mosaic Model of Membrane Structure: still relevant to understanding the structure, function and dynamics of biological membranes after more than 40 years. Biochim. Biophys. Acta 2014; 1838: 1451-1466. View Full Paper

Rosshart et al. Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance. Cell, 2017 DOI: 10.1016/j.cell.2017.09.016.

Troy D. Hubbard, Iain A. Murray, Robert G. Nichols, Kaitlyn Cassel, Michael Podolsky, Guray Kuzu, Yuan Tian, Phillip Smith, Mary J. Kennett, Andrew D. Patterson, Gary H. Perdew. Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner. Journal of Functional Foods, 2017; 37: 685 DOI: 10.1016/j.jff.2017.08.038.

Christopher L. Hager, Mahmoud A. Ghannoum. The mycobiome: Role in health and disease, and as a potential probiotic target in gastrointestinal disease. Digestive and Liver Disease, 2017; DOI: 10.1016/j.dld.2017.08.025.

Tiffani Alvey Jones, Diane Z. Hernandez, Zoë C. Wong, Anica M. Wandler, Karen Guillemin. The bacterial virulence factor CagA induces microbial dysbiosis that contributes to excessive epithelial cell proliferation in the Drosophila gut. PLOS Pathogens, 2017; 13 (10): e1006631 DOI: 10.1371/journal.ppat.1006631


Dorothy K. Sit, James McGowan, Christopher Wiltrout, Rasim Somer Diler, John (Jesse) Dills, James Luther, Amy Yang, Jody D. Ciolino, Howard Seltman, Stephen R. Wisniewski, Michael Terman, Katherine L. Wisner. Adjunctive Bright Light Therapy for Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Trial. American Journal of Psychiatry, 2017; appi.ajp.2017.1 DOI: 10.1176/appi.ajp.2017.16101200

Xiangyun Zhu et al. Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis. Nutrition & Metabolism 2017,14:60.

Kootte et al. Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition. Cell Metabolism, 2017 DOI: 10.1016/j.cmet.2017.09.008

Katherine McGuire, J.Antonio Avina-Zubieta, John M. Esdaile, Mohsen Sadatsafavi, Eric C. Sayre, Michal Abrahamowicz, Diane Lacaille. Risk of Incident Chronic Obstructive Pulmonary Disease (COPD) in Rheumatoid Arthritis: A Population Based Cohort Study. Arthritis Care & Research, 2017; DOI: 10.1002/acr.23410.

Ian J. Wallace et al. Knee osteoarthritis has doubled in prevalence since the mid-20th century PNAS 2017 114 (35) 9332-9336; doi:10.1073/pnas.1703856114

Timothy Heisel, Emmanuel Montassier, Abigail Johnson, Gabriel Al-Ghalith, Yi-Wei Lin, Li-Na Wei, Dan Knights, Cheryl A. Gale. High-Fat Diet Changes Fungal Microbiomes and Interkingdom Relationships in the Murine Gut. mSphere, October 2017 DOI: 10.1128/mSphere.00351-17.

Wendy S White, Yang Zhou, Agatha Crane, Philip Dixon, Frits Quadt, Leonard M Flendrig. Modeling the dose effects of soybean oil in salad dressing on carotenoid and fat-soluble vitamin bioavailability in salad vegetables. The American Journal of Clinical Nutrition, 2017; 106 (4): 1041 DOI: 10.3945/%u200Bajcn.117.153635

October 2017

IHCAN October references


Nisha Rao, Henry A. Spiller, Nichole L. Hodges, Thiphalak Chounthirath, Marcel J. Casavant, Amrit K. Kamboj, Gary A. Smith. An Increase in Dietary Supplement Exposures Reported to US Poison Control Centers. Journal of Medical Toxicology, 2017; DOI: 10.1007/s13181-017-0623-7.

Crawley EM, Gaunt DM, Garfield K, et al. Clinical and cost-effectiveness of the Lightning Process in addition to specialist medical care for paediatric chronic fatigue syndrome: randomised controlled trial. Archives of Disease in Childhood. Published Online First: 20 September 2017. doi: 10.1136/archdischild-2017-313375.

Chunxu Gao, Bhanu Priya Ganesh, Zhongcheng Shi, Rajesh Rasik Shah, Robert Fultz, Angela Major, Susan Venable, Monica Lugo, Kathleen Hoch, Xiaowei Chen, Anthony Haag, Timothy C. Wang, James Versalovic. Gut Microbe–Mediated Suppression of Inflammation-Associated Colon Carcinogenesis by Luminal Histamine Production. The American Journal of Pathology, 2017; DOI: 10.1016/j.ajpath.2017.06.011

NEW RELEASES – migraine

Lidiane Lima Florencio, Anamaria Siriani de Oliveira, Gabriela Ferreira Carvalho, Fabiola Dach, Marcelo Eduardo Bigal, César Fernández-de-las-Peñas, Débora Bevilaqua-Grossi. Association Between Severity of Temporomandibular Disorders and the Frequency of Headache Attacks in Women With Migraine: A Cross-Sectional Study. Journal of Manipulative and Physiological Therapeutics, 2017; 40 (4): 250 DOI: 10.1016/j.jmpt.2017.02.006.

BEN BROWN: Alzheimer’s


1.             Beilharz JE, Maniam J, Morris MJ. Diet-Induced Cognitive Deficits: The Role of Fat and Sugar, Potential Mechanisms and Nutritional Interventions. Nutrients. 2015 Aug 12;7(8):6719-38.2.             Petersson SD, Philippou E. Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence. Adv Nutr. 2016 Sep 15;7(5):889-904.3.             McMillan L, Owen L, Kras M, Scholey A. Behavioural effects of a 10-day Mediterranean diet. Results from a pilot study evaluating mood and cognitive performance. Appetite. 2011 Feb;56(1):143-7.

  1. Smith PJ, Blumenthal JA, Babyak MA, Craighead L, Welsh- Bohmer KA, Browndyke JN, et al. Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure. Hypertension 2010;55:1331–8.

5.             Martínez-Lapiscina EH, Clavero P, Toledo E, Estruch R, Salas-Salvadó J, San Julián B, Sanchez-Tainta A, Ros E, Valls-Pedret C, Martinez-Gonzalez MÁ. Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomized trial. J Neurol Neurosurg Psychiatry. 2013 Dec;84(12):1318-25.6.             Valls-Pedret C, Sala-Vila A, Serra-Mir M, Corella D, de la Torre R, Martínez-González MÁ, Martínez-Lapiscina EH, Fitó M, Pérez-Heras A, Salas-Salvadó J, Estruch R, Ros E. Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial. JAMA Intern Med. 2015 Jul;175(7):1094-103.7.             Knight A, Bryan J, Wilson C, Hodgson JM, Davis CR, Murphy KJ. The Mediterranean Diet and Cognitive Function among Healthy Older Adults in a 6-Month Randomised Controlled Trial: The MedLey Study. Nutrients. 2016 Sep 20;8(9).8.             Morris MC, Tangney CC, Wang Y, Sacks FM, Barnes LL, Bennett DA, Aggarwal NT. MIND diet slows cognitive decline with aging. Alzheimers Dement. 2015 Sep;11(9):1015-22.9.             Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT. MIND diet associated with reduced incidence of Alzheimer’s disease. Alzheimers Dement. 2015 Sep;11(9):1007-14.

  1. Morris MC. MIND Diet Intervention and Cognitive Decline (MIND). Accessed on on September 15th, 2017.

11.         Bland J. Mild Cognitive Impairment, Neurodegeneration, and Personalized Lifestyle Medicine. Integr Med (Encinitas). 2016 Apr;15(2):12-4.12.         Schelke MW, Hackett K, Chen JL, Shih C, Shum J, Montgomery ME, Chiang GC, Berkowitz C, Seifan A, Krikorian R, Isaacson RS. Nutritional interventions for Alzheimer’s prevention: a clinical precision medicine approach. Ann N Y Acad Sci. 2016 Mar;1367(1):50-6.13.         Bredesen DE. Reversal of cognitive decline: a novel therapeutic program. Aging (Albany NY). 2014 Sep;6(9):707-17. 14.         Bredesen DE, Amos EC, Canick J, Ackerley M, Raji C, Fiala M, Ahdidan J. Reversal of cognitive decline in Alzheimer’s disease. Aging (Albany NY). 2016 Jun;8(6):1250-8.15.         Koppel SJ, Swerdlow RH. Neuroketotherapeutics: A modern review of a century-old therapy. Neurochem Int. 2017 Jun 1. pii: S0197-0186(17)30227-9.16.         Cunnane SC, Courchesne-Loyer A, St-Pierre V, Vandenberghe C, Pierotti T, Fortier M, Croteau E, Castellano CA. Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer’s disease. Ann N Y Acad Sci. 2016 Mar;1367(1):12-20.17.         Yin JX, Maalouf M, Han P, Zhao M, Gao M, Dharshaun T, Ryan C, Whitelegge J, Wu J, Eisenberg D, Reiman EM, Schweizer FE, Shi J. Ketones block amyloid entry and improve cognition in an Alzheimer’s model. Neurobiol Aging. 2016 Mar;39:25-37.18.         Bough KJ, Wetherington J, Hassel B, Pare JF, Gawryluk JW, Greene JG, Shaw R, Smith Y, Geiger JD, Dingledine RJ. Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet. Ann Neurol. 2006 Aug;60(2):223-35.19.         Yang X, Cheng B. Neuroprotective and anti-inflammatory activities of ketogenic diet on MPTP-induced neurotoxicity. J Mol Neurosci. 2010 Oct;42(2):145-53.20.         Krikorian R, Shidler MD, Dangelo K, Couch SC, Benoit SC, Clegg DJ. Dietary ketosis enhances memory in mild cognitive impairment. Neurobiol Aging. 2012

  1. Henderson ST, Vogel JL, Barr L, Garvin F, Jones JJ, Costantini LG. Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer’s disease: a randomized, double-blind, placebo-controlled, multicenter trial. Nutrition & Metabolism. 2009;6:31.

22.         Maynard SD, Gelblum J. Retrospective cohort study of the efficacy of caprylic triglyceride in patients with mild-to-moderate alzheimer’s disease. Neuropsychiatr Dis Treat. 2013;9:1619-27.23.         Farah BA. Effects of caprylic triglyceride on cognitive performance and cerebral glucose metabolism in mild Alzheimer’s disease: a single-case observation. Front Aging Neurosci. 2014 Jul 16;6:133.24.         Ohnuma T, Toda A, Kimoto A, et al. Benefits of use, and tolerance of, medium-chain triglyceride medical food in the management of Japanese patients with Alzheimer’s disease: a prospective, open-label pilot study. Clin Interv Aging. 2016 Jan 8;11:29-36.

  1. Gandotra S, Kour J, Van der Waag A. Efficacy of Adjunctive Extra Virgin Coconut Oil Use in Moderate to Severe Alzheimer’s Disease. Int J Sch Cog Psychol 2014, 1:2

26.         Kapogiannis D, Mattson MP. Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer’s disease. Lancet Neurol. 2011 Feb;10(2):187-98.

  1. Mattson MP. Challenging oneself intermittently to improve health. Dose Response. 2014 Oct 20;12(4):600-18.

28.         Wahl D, Cogger VC, Solon-Biet SM, Waern RV, Gokarn R, Pulpitel T, Cabo Rd, Mattson MP, Raubenheimer D, Simpson SJ, Le Couteur DG. Nutritional strategies to optimise cognitive function in the aging brain. Ageing Res Rev. 2016 Nov;31:80-92.29.         Witte AV, Fobker M, Gellner R, Knecht S, Flöel A. Caloric restriction improves memory in elderly humans. Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1255-60.30.         Martin CK, Anton SD, Han H, York-Crowe E, Redman LM, Ravussin E, Williamson DA. Examination of cognitive function during six months of calorie restriction: results of a randomized controlled trial. Rejuvenation Res. 2007 Jun;10(2):179-90.31.         Scott TM, Rasmussen HM, Chen O, Johnson EJ. Avocado Consumption Increases Macular Pigment Density in Older Adults: A Randomized, Controlled Trial. Nutrients. 2017 Aug 23;9(9). 32.         Krikorian R, Shidler MD, Nash TA, Kalt W, Vinqvist-Tymchuk MR, Shukitt-Hale B, Joseph JA. Blueberry supplementation improves memory in older adults. J Agric Food Chem. 2010 Apr 14;58(7):3996-4000.

  1. Rita Cardoso B, Apolinário D, da Silva Bandeira V, et al. Effects of Brazil nut consumption on selenium status and cognitive performance in older adults with mild cognitive impairment: a randomized controlled pilot trial.Eur J Nutr. 2016 Feb;55(1):107-16.

34.         Kent K, Charlton K, Roodenrys S, et al. Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia. Eur J Nutr. 2017 Feb;56(1):333-341.

  1. Krikorian R, Nash TA, Shidler MD, Shukitt-Hale B, Joseph JA. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr. 2010 Mar;103(5):730-4.

36.         Krikorian R, Boespflug EL, Fleck DE, Stein AL, Wightman JD, Shidler MD, Sadat-Hossieny S. Concord grape juice supplementation and neurocognitive function in human aging. J Agric Food Chem. 2012 Jun 13;60(23):5736-42.37.         Ide K, Yamada H, Takuma N, Park M, Wakamiya N, Nakase J, Ukawa Y, Sagesaka YM. Green tea consumption affects cognitive dysfunction in the elderly: a pilot study. Nutrients. 2014 Sep 29;6(10):4032-42.38.         Parachikova A, Green KN, Hendrix C, LaFerla FM. Formulation of a medical food cocktail for Alzheimer’s disease: beneficial effects on cognition and neuropathology in a mouse model of the disease. PLoS One. 2010 Nov 17;5(11):e14015. 39.         Chan A, Paskavitz J, Remington R, et al. Efficacy of a vitamin/nutriceutical formulation for early-stage Alzheimer’s disease: a 1 year, open-label pilot study with an 16-month caregiver extension. Am J Alzheimers Dis Other Demen. 2008 Dec-2009 Jan;23(6):571-85. 40.         Remington R, Bechtel C, Larsen D, et al. A Phase II Randomized Clinical Trial of a Nutritional Formulation for Cognition and Mood in Alzheimer’s Disease. J Alzheimers Dis. 2015;45(2):395-405.41.         Remington R, Bechtel C, Larsen D, et al. Maintenance of Cognitive Performance and Mood for Individuals with Alzheimer’s Disease Following Consumption of a Nutraceutical Formulation: A One-Year, Open-Label Study. J Alzheimers Dis. 2016;51(4):991-5. 42.         Zanotta D, Puricelli S, Bonoldi G. Cognitive effects of a dietary supplement made from extract of Bacopa monnieri, astaxanthin, phosphatidylserine, and vitamin E in subjects with mild cognitive impairment: a noncomparative, exploratory clinical study. Neuropsychiatr Dis Treat. 2014 Feb 3;10:225-30.43.         Galasko DR, Peskind E, Clark CM, Quinn JF, Ringman JM, Jicha GA, Cotman C, Cottrell B, Montine TJ, Thomas RG, Aisen P; Alzheimer’s Disease Cooperative Study. Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. Arch Neurol. 2012 Jul;69(7):836-41.44.         Smith AD, Refsum H. Homocysteine, B Vitamins, and Cognitive Impairment. Annu Rev Nutr. 2016 Jul 17;36:211-39.45.         Douaud G, Refsum H, de Jager CA, Jacoby R, Nichols TE, Smith SM, Smith AD. Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9523-8.

  1. de Jager CA, Oulhaj A, Jacoby R, Refsum H, Smith AD. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: A randomized controlled trial. Int J Geriatr Psychiatry. 2012;27(6):592–600.

47.         Cheng D, Kong H, Pang W, Yang H, Lu H, Huang C, Jiang Y. B vitamin supplementation improves cognitive function in the middle aged and elderly with hyperhomocysteinemia. Nutr Neurosci. 2016 Dec;19(10):461-466.48.         Oulhaj A, Jernerén F, Refsum H, Smith AD, de Jager CA. Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment. J Alzheimers Dis. 2016;50(2):547-57.49.         Ma F, Wu T, Zhao J, Han F, Marseglia A, Liu H, Huang G. Effects of 6-Month Folic Acid Supplementation on Cognitive Function and Blood Biomarkers in Mild Cognitive Impairment: A Randomized Controlled Trial in China. J Gerontol A Biol Sci Med Sci. 2016 Oct;71(10):1376-83.50.         Chen H, Liu S, Ji L, Wu T, Ji Y, Zhou Y, Zheng M, Zhang M, Xu W, Huang G. Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial. Mediators Inflamm. 2016;2016:5912146.51.         Werder SF. Cobalamin deficiency, hyperhomocysteinemia, and dementia. Neuropsychiatr Dis Treat. 2010 May 6;6:159-95.52.         Eastley R, Wilcock GK, Bucks RS. Vitamin B12 deficiency in dementia and cognitive impairment: the effects of treatment on neuropsychological function. Int J Geriatr Psychiatry. 2000 Mar;15(3):226-33.53.         Kwok T, Lee J, Lam L, Woo J. Vitamin B(12) supplementation did not improve cognition but reduced delirium in demented patients with vitamin B(12) deficiency. Arch Gerontol Geriatr. 2008 May-Jun;46(3):273-82.54.         van Dyck CH, Lyness JM, Rohrbaugh RM, Siegal AP. Cognitive and psychiatric effects of vitamin B12 replacement in dementia with low serum B12 levels: a nursing home study. Int Psychogeriatr. 2009 Feb;21(1):138-47.55.         Chai GS, Jiang X, Ni ZF, Ma ZW, Xie AJ, Cheng XS, Wang Q, Wang JZ, Liu GP. Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine. J Neurochem. 2013 Feb;124(3):388-96.56.         Sun J, Wen S, Zhou J, Ding S. Association between malnutrition and hyperhomocysteine in Alzheimer’s disease patients and diet intervention of betaine. J Clin Lab Anal. 2016 Nov 7. doi: 10.1002/jcla.22090. [Epub ahead of print]57.         Wu S, Ding Y, Wu F, Li R, Hou J, Mao P. Omega-3 fatty acids intake and risks of dementia and Alzheimer’s disease: a meta-analysis. Neurosci Biobehav Rev. 2015 Jan;48:1-9.58.         Ammann EM, Pottala JV, Robinson JG, Espeland MA, Harris WS. Erythrocyte omega-3 fatty acids are inversely associated with incident dementia: Secondary analyses of longitudinal data from the Women’s Health Initiative Memory Study (WHIMS). Prostaglandins Leukot Essent Fatty Acids. 2017 Jun;121:68-75.59.         Pottala JV, Yaffe K, Robinson JG, Espeland MA, Wallace R, Harris WS. Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study. Neurology. 2014 Feb 4;82(5):435-42.60.         Fraga VG, Carvalho MDG, Caramelli P, de Sousa LP, Gomes KB. Resolution of inflammation, n-3 fatty acid supplementation and Alzheimer disease: A narrative review. J Neuroimmunol. 2017 Sep 15;310:111-119.61.         Freund Levi Y, Vedin I, Cederholm T, Basun H, Faxén Irving G, Eriksdotter M, Hjorth E, Schultzberg M, Vessby B, Wahlund LO, Salem N Jr, Palmblad J. Transfer of omega-3 fatty acids across the blood-brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer’s disease: the OmegAD study. J Intern Med. 2014 Apr;275(4):428-36.62.         Eriksdotter M, Vedin I, Falahati F, Freund-Levi Y, Hjorth E, Faxen-Irving G, Wahlund LO, Schultzberg M, Basun H, Cederholm T, Palmblad J. Plasma Fatty Acid Profiles in Relation to Cognition and Gender in Alzheimer’s Disease Patients During Oral Omega-3 Fatty Acid Supplementation: The OmegAD Study. J Alzheimers Dis. 2015;48(3):805-12.63.         Vedin I, Cederholm T, Freund-Levi Y, Basun H, Garlind A, Irving GF, Eriksdotter-Jönhagen M, Wahlund LO, Dahlman I, Palmblad J. Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study. PLoS One. 2012;7(4):e35425.64.         Nock TG, Chouinard-Watkins R, Plourde M. Carriers of an apolipoprotein E epsilon 4 allele are more vulnerable to a dietary deficiency in omega-3 fatty acids and cognitive decline. Biochim Biophys Acta. 2017 Oct;1862(10 Pt A):1068-1078.65.         Holmquist L, Stuchbury G, Berbaum K, Muscat S, Young S, Hager K, Engel J, Münch G. Lipoic acid as a novel treatment for Alzheimer’s disease and related dementias. Pharmacol Ther. 2007 Jan;113(1):154-64.

  1. Fava A, Pirritano D, Plastino M, et al. The effect of lipoic acid therapy on cognitive functioning in patients with Alzheimer’s Disease. J Neurodegener Dis. 2013; 2013:454253.

67.         Shinto L, Quinn J, Montine T, et al. A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer’s disease. J Alzheimers Dis. 2014;38(1):111 20.68.         Pepeu G, Pepeu IM, Amaducci L. A review of phosphatidylserine pharmacological and clinical effects. Is phosphatidylserine a drug for the ageing brain?Pharmacol Res. 1996 Feb;33(2):73-80.69.         Richter Y, Herzog Y, Lifshitz Y, Hayun R, Zchut S. The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study. Clin Interv Aging. 2013;8:557-63.70.         Richter Y, Herzog Y, Cohen T, Steinhart Y. The effect of phosphatidylserine-containing omega-3 fatty acids on memory abilities in subjects with subjective memory complaints: a pilot study. Clin Interv Aging. 2010 Nov 2;5:313-6.71.         Moré MI, Freitas U, Rutenberg D. Positive effects of soy lecithin-derived phosphatidylserine plus phosphatidic acid on memory, cognition, daily functioning, and mood in elderly patients with Alzheimer’s disease and dementia. Adv Ther. 2014 Dec;31(12):1247-672.         Kato-Kataoka A, Sakai M, Ebina R, Nonaka C, Asano T, Miyamori T. Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. J Clin Biochem Nutr. 2010 Nov;47(3):246-5573.         Skvarc DR, Dean OM, Byrne LK, Gray L, Lane S, Lewis M, Fernandes BS, Berk M, Marriott A. The effect of N-acetylcysteine (NAC) on human cognition – A systematic review. Neurosci Biobehav Rev. 2017 Jul;78:44-56.

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  1. DiNicolantonio JJ et al. Targeting aspirin resistance with nutraceuticals: A possible strategy for reducing cardiovascular morbidity and mortality. Open Heart 2017, 4(2).
  2. Hydrogen Peroxide Watery Fuel for Change in Vascular Biology,

Frank M. Faraci. Arteriosclerosis, Thrombosis, and Vascular Biology 2006;26:1931-1933.

  1. Zagli G et al. Hydrogen sulfide inhibits human platelet aggregation. European Journal of Pharmacology 2007, 559(1): 65-68.
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Devries S et al. A deficiency of nutrition education and practice in cardiology. Am J Med 2017, 127: 9.

Maryam Sharifi‐Sanjani, Nicholas M. Oyster, Elisia D. Tichy, Kenneth C. Bedi, Ofer Harel, Kenneth B. Margulies, Foteini Mourkioti. Cardiomyocyte‐Specific Telomere Shortening is a Distinct Signature of Heart Failure in Humans. Journal of the American Heart Association, September 2017 DOI: 10.1161/JAHA.116.005086.

FRONTIERS: Simon Mills
1. Bennett HD et al. Health coaching for patients with chronic illness. Fam Pract Manag 210, 17, 5, 24-9.


Paul Gellert, Petra von Berenberg, Monika Oedekoven, Maria Klemt, Christine Zwillich, Stefan Hörter, Adelheid Kuhlmey, Dagmar Dräger. Centenarians Differ in Their Comorbidity Trends During The 6 Years Before Death Compared to Individuals Who Died in Their 80s or 90s. The Journals of Gerontology: Series A, 2017; DOI: 10.1093/gerona/glx136.

Ashley A. Ross, Andrew C. Doxey, Josh D. Neufeld. The Skin Microbiome of Cohabiting Couples. mSystems, July 2017 DOI: 10.1128/mSystems.00043-17 .

Claire T. McEvoy, Heidi Guyer, Kenneth M. Langa, Kristine Yaffe. Neuroprotective Diets Are Associated with Better Cognitive Function: The Health and Retirement Study. Journal of the American Geriatrics Society, 2017; DOI: 10.1111/jgs.14922.

Eric L. Garland, Anne K. Baker, Paula Larsen, Michael R. Riquino, Sarah E. Priddy, Elizabeth Thomas, Adam W. Hanley, Patricia Galbraith, Nathan Wanner, Yoshio Nakamura. Randomized Controlled Trial of Brief Mindfulness Training and Hypnotic Suggestion for Acute Pain Relief in the Hospital Setting. Journal of General Internal Medicine, 2017; DOI: 10.1007/s11606-017-4116-9.

Ather Ali, Theresa R Weiss, Douglas McKee, Alisa Scherban, Sumiya Khan, Maxine R Fields, Damian Apollo, Wajahat Z Mehal. Efficacy of individualised diets in patients with irritable bowel syndrome: a randomised controlled trial. BMJ Open Gastroenterology, 2017; 4 (1): e000164 DOI: 10.1136/bmjgast-2017-000164

Ling Wu, Paul Velander, Dongmin Liu, Bin Xu. Olive component oleuropein promotes β-cell insulin secretion and protects β-cells from amylin amyloid induced cytotoxicity. Biochemistry, 2017; DOI: 10.1021/acs.biochem.7b00199.

M F Hjorth, H M Roager, T M Larsen, S K Poulsen, T R Licht, M I Bahl, Y Zohar, A Astrup.

Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention. International Journal of Obesity, 2017; DOI: 10.1038/ijo.2017.220.


In Focus - Lyme Disease 2017

[1] Sapi E, Kaur N, Anyanwu S, Luecke DF, Datar A, Patel S, Rossi M, Stricker RB (2011) Evaluation of in-vitro antibiotic susceptibility of different morphological forms of Borrelia burgdorferi.  Infect Drug Resist 4:97-113



[1] Kenedy MR, Lenhart TR, Akins DR (2012) The role of Borrelia burgdorferi Outer Surface Proteins.  FEMS Immunol Med Microbiol 66:1-19



[1] Zhang J-R, Norris SJ (1998) Kinetics and in vivo induction of genetic variation of vlsE in Borrelia burgdorferi.  Infection and Immunity 66:3689-3697



[1] Embers ME, Ramamoorthy R, Philipp MT (2004) Survival strategies of Borrelia burgdorferi, the etiologic agent of Lyme disease.  Microbes and Infection 6:312-318



[1] Kuehn BM (2013) CDC estimates 300000 US cases of Lyme disease annually.  JAMA 310: 1110



[1] Lindgren E, Jaenson T and World Health Organization (2006) Lyme borreliosis in Europe: influences and climate change, epidemiology, ecology and adaptation measures. World Health Organization Regional Office for Europe



[1] Van den Wijngaard CC, Hofhuls A, Simoes M, Rood E, van Pelt W, Zeller H, Van Bortel W (2017) Surveillance perspective on Lyme borreliosis across the European Union and European Economic Area.  Euro Surveill 22 pii=30569



[1] Dubrey SW, Bhatia A, Woodham S, Rakowicz W (2013) Lyme disease in the United Kingdom.  Postgrad Med J 90:33-42



[1] Semenza JC, Menne B (2009) Climate change and infectious diseases in Europe. Lancet 9:365-375.



[1]Semenza JC, Menne B (2009) Climate change and infectious diseases in Europe. Lancet 9:365-375.



[1] Shaw SE, Day MJ, Birtles RJ, Breitschwerdt EB (2001) Tick-borne infectious diseases of dogs.  Trends in parasitology 17:74-80



[1] Harvey WT, Salvato P (2003) ‘Lyme disease’: ancient engine of an unrecognized borreliosis pandemic?  Medical Hypotheses 60:742-759



[1] Munro H, Mavin S, Duffy K, Evans R, Jarvis LM (2015) Seroprevalence of lyme borreliosis in Scottish blood donors.  Transfusion Medicine 25:284-286



[1] Zambrano MC, Beklemisheva AA, Bryksin AV, Newman SA, Cabello FC (2004) Borrelia burgdorferi binds to, invades and colonizes Native Type I Collagen Lattices.  Infection and Immunity 72:3138-3146



[1] Muller KE (2012) Damage of collagen and elastin fibres by Borrelia burgdorferi—known and new clinical and histopathological aspects.  The Open Neurology Journal 6(Suppl 1-M11):179-186



[1] Zambrano MC, Beklemisheva AA, Bryksin AV, Newman SA, Cabello FC (2004) Borrelia burgdorferi binds to, invades and colonizes Native Type I Collagen Lattices.  Infection and Immunity 72:3138-3146



[1] Tilly K, Rosa PA, Stewart PE (2008) Biology of infection with Borrelia burgdorferiInfect Dis Clin North Am 22:217-234



[1] Envita medical Centre (2017) Symptoms of Lyme Disease—the Great Imitator. Available at:  [Accessed 6th September 2017][1] Ingram C (2015) Lyme Disease Mimics a Vast Number of Other Diseases.   Available at:   [Accessed 7th September 2017][1] Gülçin I, Oktay M, Kireçci E, Küfrevioğlu I (2003) Screening of antioxidant and antimicrobial activities of anise (Pimpinella anisum L.) seed extracts.  Food Chemistry 83:371-382



[1] Francis G, Karem Z, Makkar HP, Becker K (2002) The biological action of saponins in animal systems: a review.  Br J Nutr 88:587-605.



[1] Kim B-Y, Cui Z-G, Lee S-R, Kim S-J, Kang H-K, Lee Y-K, Park D-B (2009) Effects of Asparagus officinalis extracts on cell toxicity and ethanol metabolism.  Journal of Food Science 74:H204-208



[1] Arthur S (2007) The effectiveness of Samento, Cumanda, Burbur and Dr Lee Cowden’s Protocol in the treatment of chronic Lyme disease.  Townsend Letter for Doctors and Patients 285:101



[1] Tan KH, Seers CA, Dashper SG, Mitchell HL, Pyke JS, Meuric V, Slakeski N, Cheal SM, Chambers JL, McConville MJ, Reynolds EC (2014) Porphyromonas gingivalis and Treponema denticola exhibit metabolic symbioses. PLoS Pathog 10(3): e1003955



[1] Brambilla E, Gagetti MG, Ionescu A, Campus G, Lingstrom P (2014) An in vitro and in vivo comparison of the effect of Stevia rebaudiana extracts on different caries-related variables: a randomized controlled trial pilot study.  Caries Res 48:19-23



[1] Theophilus PAS, Victoria MJ, Socarras KM, Filush KR, Gupta K, Luecke DF, Sapi E (2015) Effectiveness of Stevia rebaudiana whole leaf extract against the various morphological forms of Borrelia burgdorferi in vitroEuropean Journal of Microbiology and Immunology 5:268-280.



[1] Dryden M, Gaff H, McCombs G, Medlock J, Pietzsch M (2015) The dangers of tick-borne diseases: considerations for dental professionals. DH & T October:26-29



[1] Drenckhahn A, Spors B,Knierim E (2016) Acute isolated partial oculomotor nerve palsy due to Lyme neuroborreliosis in a 5 year old girl.  European Journal of Paediatric Neurology 20:977-979



[1] Lesser RL (1995) Ocular manifestations of Lyme disease.  The American Journal of Medicine 98(4): Supplement 1:60S-62S



[1] Guliani BP, Kuman S, Chawla N, Mehta A (2017) Neuroretinitis as presenting and the only presentation of Lyme disease: Diagnosis and management.  Indian Journal of Ophthalmology 65(3) 250-25



[1] Guliani BP, Kuman S, Chawla N, Mehta A (2017) Neuroretinitis as presenting and the only presentation of Lyme disease: Diagnosis and management.  Indian Journal of Ophthalmology 65(3) 250-252



[1] Klig JE (2008) Ophthalmologic Complications of Systemic Disease.  Emerg Med Clin N. Am 26:217-231Klig



[1] Steere AC, Duray PH, Kauffmann JH, Wormser GP (1985) Unilateral Blindness Caused by Infection with the Lyme Disease Spirochete, Borrelia burgdorferiAnnals of Internal Medicine 103(3): 382-384



[1] World Health Organization (2017) Trachoma.  Available at:    [Accessed 6th September 2017][1] Envita Medical Centre (2017)  Bartonella, a chronic Lyme disease coinfection, is more causing chronic fatigue problems.   Available at:  [Accessed 6th September 2017][1] Klig JE (2008) Ophthalmologic Complications of Systemic Disease.  Emerg Med Clin N. Am 26:217-231



[1] Klig JE (2008) Ophthalmologic Complications of Systemic Disease.  Emerg Med Clin N. Am 26:217-231



[1] Denniston AK, Keane PA (2015) Letter: Paravascular Pathways in the Eye: Is there an ‘Ocular Glymphatic System’?   Invest Ophthalmol Vis Sci 56:3955-3956




Lyme Disease and linked conditions:


  1. Luger SW (1990) Lyme disease transmitted by a biting fly. New England Journal of Medicine 322 (24):1752.
  2. Stricker RB, Middelveen MJ (2015) Sexual transmission of Lyme disease: challenging the tickborne disease paradigm. Expert review of anti-infective therapy 13 (11):1303-1306.
  3. Klempner MS, Schmid CH, Hu L, Steere AC, Johnson G, McCloud B, Noring R, Weinstein A (2001) Intralaboratory reliability of serologic and urine testing for Lyme disease. American Journal of Medicine 110 (3):217-219.
  4. Ghoneum M, Abedi S (2004) Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran). Journal of Pharmacy and Pharmacology 56 (12):1581-1588.
  5. Perez-Martinez A, Valentin J, Fernandez L, Hernandez-Jimenez E, Lopez-Collazo E, Zerbes P, Schworer E, Nunez F, Martin IG, Sallis H, Diaz MA, Handgretinger R, Pfeiffer MM (2015) Arabinoxylan rice bran (MGN-3/Biobran) enhances natural killer cell-mediated cytotoxicity against neuroblastoma in vitro and in vivo. Cytotherapy 17 (5):601-612.
September 2017


Baker H, DeAngelis B, Holland B, Gittens-Williams L, Barrett T Jr. Vitamin Profile of 563 Gravidas during Trimesters of Pregnancy. Journal of the American College of Nutrition 2002;21(1):33–7.

 NAD Deficiency, Congenital Malformations, and Niacin Supplementation

Hongjun Shi et al. N Engl J Med 2017; 377:544-552. August 10, 2017 DOI: 10.1056/NEJMoa1616361.

 Long-term clinical and immunological effects of probiotic and peanut oral immunotherapy after treatment cessation: 4-year follow-up of a randomised, double-blind, placebo-controlled trial

Kuang-Chih Hsiao et al. The Lancet, Child and Adolescent Health, 15 August 2017.


 Luisa Cimmino et al. Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression. Cell, 2017; DOI: 10.1016/j.cell.2017.07.032.


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7.      Bland J. Mild Cognitive Impairment, Neurodegeneration, and Personalised Lifestyle Medicine. Integr Med (Encinitas). 2016 Apr;15(2):12-4.

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10.  Nehls M. Unified theory of Alzheimer’s disease (UTAD): implications for prevention and curative therapy. J Mol Psychiatry. 2016 Jul 15;4:3.

11.  Bhattacharjee S, Lukiw WJ. Alzheimer’s disease and the microbiome. Front Cell Neurosci. 2013 Sep 17;7:153.

12.  Jiang C, Li G, Huang P, Liu Z, Zhao B. The Gut Microbiota and Alzheimer’s Disease. J Alzheimers Dis. 2017;58(1):1-15.

13.  Zhao Y, Jaber V, Lukiw WJ. Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer’s Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus. Front Cell Infect Microbiol. 2017 Jul 11;7:318.

14.  Bonfili L, Cecarini V, Berardi S, et al. Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels. Sci Rep. 2017 May 25;7(1):2426.

15.  Akbari E, Asemi Z, Daneshvar Kakhaki R, Bahmani F, Kouchaki E, Tamtaji OR, Hamidi GA and Salami M (2016) Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer’s Disease: A Randomized, Double-Blind and Controlled Trial. Front. Aging Neurosci. 8:256. doi: 10.3389/fnagi.2016.00256

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17.  Rubio-Perez JM, Morillas-Ruiz JM. A review: inflammatory process in Alzheimer’s disease, role of cytokines. ScientificWorldJournal. 2012;2012:756357.

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19.  Kesse-Guyot E, Assmann KE, Andreeva VA, et al. Long-term association between  the dietary inflammatory index and cognitive functioning: findings from the SU.VI.MAX study. Eur J Nutr. 2017 Jun;56(4):1647-1655.

20.  Hayden KM, Beavers DP, Steck SE, et al. The association between an inflammatory diet and global cognitive function and incident dementia in older women: The Women’s Health Initiative Memory Study. Alzheimers Dement. 2017 May 19. pii: S1552-5260(17)30185-1

21.  Gardener SL, Rainey-Smith SR, Martins RN. Diet and Inflammation in Alzheimer’s Disease and Related Chronic Diseases: A Review. J Alzheimers Dis. 2016;50(2):301-34.

22.  Esposito K, Marfella R, Ciotola M, Di Palo C, Giugliano F, Giugliano G, D’Armiento M, D’Andrea F, Giugliano D. Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA. 2004 Sep 22;292(12):1440-6.

23.  Singh B, Parsaik AK, Mielke MM, Erwin PJ, Knopman DS, Petersen RC, Roberts RO. Association of mediterranean diet with mild cognitive impairment and Alzheimer’s  disease: a systematic review and meta-analysis. J Alzheimers Dis. 2014;39(2):271-82.

24.  Valls-Pedret C, et al. Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial. JAMA Intern Med. 2015 Jul;175(7):1094-103

25.  Gandhi S, Abramov AY. Mechanism of oxidative stress in neurodegeneration. Oxid Med Cell Longev. 2012;2012:428010

26.  Zhao Y, Zhao B. Oxidative stress and the pathogenesis of Alzheimer’s disease. Oxid Med Cell Longev. 2013;2013:316523. 

27.  Praticò D. Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal. Trends Pharmacol Sci. 2008 Dec;29(12):609-15.

28.  Thapa A, Carroll NJ. Dietary Modulation of Oxidative Stress in Alzheimer’s Disease. Int J Mol Sci. 2017 Jul 21;18(7).

29.  Monacelli F, Acquarone E, Giannotti C, Borghi R, Nencioni A. Vitamin C, Aging  and Alzheimer’s Disease. Nutrients. 2017 Jun 27;9(7).

30.  Cervantes B, Ulatowski LM. Vitamin E and Alzheimer’s Disease-Is It Time for Personalised Medicine? Antioxidants (Basel). 2017 Jun 24;6(3).

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33.  Bayer-Carter JL, Green PS, Montine TJ, et al. Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment. Arch Neurol. 2011 Jun;68(6):743-52.

34.  Wilkins HM, Morris JK. New Therapeutics to Modulate Mitochondrial Function in  Neurodegenerative Disorders. Curr Pharm Des. 2017;23(5):731-752.

35.  Wilkins HM, Swerdlow RH. Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer’s Disease. Curr Top Med Chem. 2016;16(8):849-57.

36.  Murugaiyah V, Mattson MP. Neurohormetic phytochemicals: An evolutionary-bioenergetic perspective. Neurochem Int. 2015 Oct;89:271-80.

37.  Akbar M, Essa MM, Daradkeh G, Abdelmegeed MA, Choi Y, Mahmood L, Song BJ. Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress. Brain Res. 2016 Apr 15;1637:34-55.

38.  Nicolson GL. Mitochondrial dysfunction and chronic disease: treatment with natural supplements. Altern Ther Health Med. 2014 Winter;20 Suppl 1:18-25.

39.  Wilkins HM, Swerdlow RH. Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer’s Disease. Curr Top Med Chem. 2016;16(8):849-57.

40.  Montgomery SA, Thal LJ, Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment  of mild cognitive impairment and mild Alzheimer’s disease. Int Clin Psychopharmacol. 2003 Mar;18(2):61-71.

41.  Birkmayer JG. Coenzyme nicotinamide adenine dinucleotide: new therapeutic approach for improving dementia of the Alzheimer type. Ann Clin Lab Sci. 1996; 26:1–9

42.  Demarin V, Podobnik SS, Storga-Tomic D, Kay G. Treatment of Alzheimer’s disease with stabilized oral nicotinamide adenine dinucleotide: a randomized, double-blind study. Drugs Exp Clin Res. 2004; 30:27–33.

43.  Bondy SC. Low levels of aluminum can lead to behavioural and morphological changes associated with Alzheimer’s disease and age-related neurodegeneration. Neurotoxicology. 2016 Jan;52:222-9.

44.  Tyler CR, Allan AM. The Effects of Arsenic Exposure on Neurological and Cognitive Dysfunction in Human and Rodent Studies: A Review. Curr Environ Health  Rep. 2014 Mar 21;1:132-147.

45.  Wang B, Du Y. Cadmium and its neurotoxic effects. Oxid Med Cell Longev. 2013;2013:898034.

46.  Bakulski KM, Rozek LS, Dolinoy DC, Paulson HL, Hu H. Alzheimer’s disease and environmental exposure to lead: the epidemiologic evidence and potential role of  epigenetics. Curr Alzheimer Res. 2012 Jun;9(5):563-73.

47.  Mutter J, Curth A, Naumann J, Deth R, Walach H. Does inorganic mercury play a  role in Alzheimer’s disease? A systematic review and an integrated molecular mechanism. J Alzheimers Dis. 2010;22(2):357-74.

48.  Yan D, Zhang Y, Liu L, Yan H. Pesticide exposure and risk of Alzheimer’s disease: a systematic review and meta-analysis. Sci Rep. 2016 Sep 1;6:32222.

49.  Wu YC, Lin YC, Yu HL, et al. Association between air pollutants and dementia risk in the elderly. Alzheimers Dement (Amst). 2015 May 14;1(2):220-8.

50.  Genuis SJ. Toxic causes of mental illness are overlooked. Neurotoxicology. 2008 Nov;29(6):1147-9

51.  Genuis SJ. Elimination of persistent toxicants from the human body. Hum Exp Toxicol. 2011 Jan;30(1):3-18.

52.  Helzner E.P, Luchsinger JA, Scarmeas N, et al. Contribution of vascular risk factors to the progression in Alzheimer disease. Arch Neurol. 2009;66:343–348.

53.  Santos CY, Snyder PJ, Wu WC, Zhang M, Echeverria A, Alber J. Pathophysiologic  relationship between Alzheimer’s disease, cerebrovascular disease, and cardiovascular risk: A review and synthesis. Alzheimers Dement (Amst). 2017 Feb 9;7:69-87.

54.  Davey DA. Alzheimer’s disease and vascular dementia: one potentially preventable and modifiable disease? Part II: Management, prevention and future perspective. Neurodegener Dis Manag. 2014;4(3):261-70.

55.  Pardeshi R, Bolshette N, Gadhave K, et al. Insulin signaling: An opportunistic target to minify the risk of Alzheimer’s disease. Psychoneuroendocrinology. 2017 Sep;83:159-171.

56.  Talbot K, Wang HY, Kazi H, et al. Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest. 2012 Apr;122(4):1316-38.

57.  Huang CC, Chung CM, Leu HB, et al. Diabetes mellitus and the risk of Alzheimer’s disease: a nationwide population-based study. PLoS One. 2014 Jan 29;9(1):e87095.

58.  Berti V, Murray J, Davies M,et al. Nutrient patterns and brain biomarkers of Alzheimer’s disease in cognitively normal individuals. J  Nutr Health Aging. 2015 Apr;19(4):413-23.

59.  Pase MP, Himali JJ, Jacques PF, DeCarli C, Satizabal CL, Aparicio H, Vasan RS, Beiser AS, Seshadri S. Sugary beverage intake and preclinical Alzheimer’s disease in the community. Alzheimers Dement. 2017 Mar 6. pii: S1552-5260(17)30050-X.

60.  Roberts RO, Roberts LA, Geda YE, et al. Relative intake of macronutrients impacts risk of mild cognitive impairment or dementia. J Alzheimers Dis. 2012;32(2):329-39.

61.  Stefanidis A, Watt MJ. Does too much sugar make for lost memories? J Physiol. 2012 Aug 15;590(16):3633-4.

62.  Feinman RD, Pogozelski WK, Astrup A, et al. Dietary carbohydrate restriction as the first approach in diabetes management: Critical review and evidence base. Nutrition. 2015 Jan;31(1):1-13

63.  Szkudelski T, Szkudelska K. Resveratrol and diabetes: from animal to human studies. Biochim Biophys Acta. 2015 Jun;1852(6):1145-54.

64.  Turner RS, Thomas RG, Craft S, van Dyck CH, Mintzer J, Reynolds BA, Brewer JB, Rissman RA, Raman R, Aisen PS; Alzheimer’s Disease Cooperative Study. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology. 2015 Oct 20;85(16):1383-91.

65.  Moussa C, Hebron M, Huang X, et al. Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease. J Neuroinflammation. 2017 Jan 3;14(1):1.

66.  Köbe T, Witte AV, Schnelle A, et al. Impact of Resveratrol on Glucose Control, Hippocampal Structure and Connectivity, and Memory Performance in Patients with Mild Cognitive Impairment. Front Neurosci. 2017 Mar 7;11:105.



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 2. Guimaraes M etal.’Effect of chromium supplementation on the glucose homeostasis and anthropometry of type 2 diabetic patients: Double blind, randomized clinical trial.’ J Trace Elem Med Biol. 2016 Jul;36:65-72

3. Paiva AN et al., ‘Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study.‘J Trace Elem Med Biol. 2015 Oct;32:66-72 -/26302914

4. H. Hemila et al., ‘Vitamin C and Infections’ Nutrients. 2017 Mar 29;9(4).

5. T Spector, ‘Epigenetics of discordant monozygotic twins: implications for disease’ Genome Med. 2014; 6(7): 60

6. Harrison S et al, ‘Does milk intake promote prostate cancer initiation or progression via effects on insulin-like growth factors (IGFs)? A systematic review and meta-analysis.’ Cancer Causes Control. 2017 Jun;28(6):497-528.

7. Bao J et al, ‘Prediction of postprandial glycemia and insulinemia in lean, young, healthy adults: glycemic load compared with carbohydrate content alone.’Am J Clin Nutr. 2011 May;93(5):984-96

8. Bischoff-Ferrari H. ‘Optimal serum 25-hydroxyvitamin D levels for multiple health outcomes.’ Adv Exp Med Biol. 2014 ;810:500-25;  also Pludowski P et al., ‘Vitamin D supplementation guidelines.’ J Steroid Biochem 2017 Feb 12. pii: S0960-0760(17)30031-6.

9. Fan S et al, ‘BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.Br J Cancer. 2006 Feb 13;94(3):407-26/16434996



Andrew Kingston, Pia Wohland, Raphael Wittenberg, Louise Robinson, Carol Brayne, Fiona E Matthews, Carol Jagger, E Green, L Gao, R Barnes, A Arthur, C Baldwin, L E Barnes, C Brayne, A Comas-Herrera, T Dening, G Forster, S Harrison, P G Ince, C Jagger, F E Matthews, I G McKeith, B Parry, J Pickett, L Robinson, B C M Stephan, S Wharton, R Wittenberg, B Woods, R Weller. Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS). The Lancet, 2017; DOI: 10.1016/S0140-6736(17)31575-1.  

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.

Xu M, Tchkonia T, Ding H, Ogrodnik M, Lubbers ER, Pirtskhalava T, White TA, Johnson KO, Stout MB, Mezera V, Giorgadze N, Jensen MD, LeBrasseur NK, Kirkland JL. Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6301-10. doi: 10.1073/pnas.1515386112. Epub 2015 Nov 2.

 Natural products targeting STAT3 signaling pathways in cancer cells. Biodesign 2016, 4 (1), 004 (01), 1-17. Yena Jin, Younghwan Kim,  Yu-Jin Lee, Dong Cho Han, Byoung-Mog Kwon.  

 Lutein and Zeaxanthin Influence Brain Function in Older Adults: A Randomized Controlled Trial. Lindbergh CA, Renzi-Hammond LM, Hammond BR, Terry DP, Mewborn CM, Puente AN, Miller LS.  J Int Neuropsychol Soc. 2017 Jul 11:1-14. doi: 10.1017/S1355617717000534. [Epub ahead of print]


Robert Sonowal, Alyson Swimm, Anusmita Sahoo, Liping Luo, Yohei Matsunaga, Ziqi Wu, Jui A. Bhingarde, Elizabeth A. Ejzak, Ayush Ranawade, Hiroshi Qadota, Domonica N. Powell, Christopher T. Capaldo, Jonathan M. Flacker, Rhienallt M. Jones, Guy M. Benian, and Daniel Kalman. Indoles from commensal bacteria extend healthspan. PNAS, August 21, 2017 DOI: 10.1073/pnas.1706464114

Olga Theou, Joanna M. Blodgett, Judith Godin, Kenneth Rockwood. Association between sedentary time and mortality across levels of frailty. Canadian Medical Association Journal, 2017; 189 (33): E1056 DOI: 10.1503/cmaj.161034.

Austin T. Mudd, Kirsten Berding, Mei Wang, Sharon M. Donovan, Ryan N. Dilger. Serum cortisol mediates the relationship between fecal Ruminococcus and brain N-acetylaspartate in the young pig. Gut Microbes, 2017; 1 DOI: 10.1080/19490976.2017.1353849

 Pinaki Panigrahi, Sailajanandan Parida, Nimai C. Nanda, Radhanath Satpathy, Lingaraj Pradhan, Dinesh S. Chandel, Lorena Baccaglini, Arjit Mohapatra, Subhranshu S. Mohapatra, Pravas R. Misra, Rama Chaudhry, Hegang H. Chen, Judith A. Johnson, J. Glenn Morris, Nigel Paneth, Ira H. Gewolb. A randomized synbiotic trial to prevent sepsis among infants in rural India. Nature, 2017; DOI: 10.1038/nature23480

 Claire E Berryman, Jennifer A Fleming, Penny M Kris-Etherton. Inclusion of Almonds in a Cholesterol-Lowering Diet Improves Plasma HDL Subspecies and Cholesterol Efflux to Serum in Normal-Weight Individuals with Elevated LDL Cholesterol. The Journal of Nutrition, 2017; 147 (8): 1517 DOI: 10.3945/jn.116.245126






In Focus - Gut Health



Chan Y., Chang T., Chan Ch., Yeh YC., Chen CW, Shieh B, Li C. Immunomodulatory effects of Agaricus blazei Murrill in Balb/cByJ mice. J microbiol immunological infect. 2007 Jun;40(3):201-8.

Chiu HF, Fu HY, Lu YY, Han YC, Shen YC, Venkatakrishnan K, Golovinskaia O, Wang CK (2017). Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers. Pharm Biol 55, 1041-1046.

Dai Yu-C, Yang Z-L, Cui B-K, et al (2009). Species diversity and utilization of medicinal mushrooms and fungi in China (review). Int J Med Mush: 11: 287?302.
Haynes, A. (2012). A Functional Medicine Approach to Auto-Imune Conditions: A Case History Led Seminar. Nutri-Link Ltd Clincal Education

Hetland G. Medicinal Effects on Tumor & Inflammation through Its Modulation of Immunity & Inflammtion. Adv. in Pharm. Scien. 2011

Liu C, Dunkin D, Lai J, Song Y, Ceballos C, Benkov K, Li XM. Anti-inflammatory Effects of Gaderma lucidum Triterpenoid in Human Crohn’s Disease Associated with Downregulation of NF

Signaling. Inflamm Bowel Dis. 2015 Aug;21(8):1918-25. doi: 10.1097/MIB.0000000000000439.

Kolotushkina EV, Moldavan MG, Voronin KY, Skibo GG. The influence of Hericium erinaceus extract on myelination process in vitro. Fiziol.Zh. 2003; vol.49(1): 38-45
Mizuno M1, Nishitani Y. Immunomodulating compounds in Basiiomycetes. J Clin Biochem Nutr. 2013 May;52(3):202-7

Takenaka MC, Robson S, Quintana FJ. Regulation of the T Cell Response by CD39. Trends Imunol. 2016 May 25. pii: S1471-4906(16)30031-X. doi: 10.1016/ [Epub ahead of print

The impact of antibiotics

[1] Voigt RM et al (2014) Circadian Disorganization Alters Intestinal Microbiota. PLoS ONE 9(5):e97500. Doi:10.1371/journal.pone.0097500


[1] Konturek PC et al (2011) Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options. J Physiol Pharmacol 62(6):591-599


[1] Conlon MA & Bird AR (2015) The Impact of Diet and Lifestyle on Gut Microbiota and Human Health. Nutrients 7(1):17-44


[1] Macpherson AJ & Harris NL (2004) Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol 4:478-485


[1] MacDonald TT & Monteleone G (2005) Immunity, Inflammation, and Allergy in the Gut. Science 307:1920-1925


[1] Round JL & Mazmanian SK (2009) The gut microbiome shapes intestinal immune responses during health and disease. Nat Rev Immunol 9(5):313-323


[1] Del Chierico F et al (2015) Phylogenetic and Metabolic Tracking of Gut Microbiota during Perinatal Development. PLoS ONE; DOI:10.1371/journal.pone.0137347


[1] Backhed F et al (2015) Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 17:690-703


[1] Tannock GW et al (2013) Comparison of the compositions of the stool microbiotas of infants fed goat milk formula, cow milk-based formula, or breast milk. Appl Environ Microbiol 79:3040-8
[1] Hussey S et al (2012) Parenteral antibiotics reduce bifidobacteria colonization and diversity in neonates. Int J Microbiol doi: 10/1155/2011/130574
[1] Chow J et al (2010) Host-Bacterial Symbiosis in Health and Disease. Adv Immunol 107:243-274


[1] Petersen C & Round JL (2014) Defining dysbiosis and its influence on host immunity and disease. Cell Microbiol 16(7):1024-1033


[1] Clemente JC et al (2012) The Impact of the Gut Microbiota on Human Health: An Integrative View. Cell 148: 1258-1270


[1] Vangay P et al (2015) Antibiotics, Pediatric Dysbiosis, and Disease. Cell Host Microbe 17(5):553-564


[1] Dethlefsen L & Relman DA (2011) Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. PNAS 108(1):4554-4561
[1] Clemente JC et al (2012) The Impact of the Gut Microbiota on Human Health: An Integrative View. Cell 148: 1258-1270
[1] Francino MP (2016). Antibiotics and the Human Gut Microbiome: Dysbioses and Accumulation of Resistances. Front Microbiol 6:1543


[1] Reid G (2006) Probiotics to prevent the need for, and augment the use of, antibiotics. Can J Infect Dis Med Microbiol 17(5):291-295


[1] Plummer SF et al (2005) Effects of probiotics on the composition of the intestinal microbiota following antibiotic therapy. Int J Antimicrob Agents 26:69-74


[1] Madden JAJ et al (2005) Effect of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: A double-blind placebo-controlled pilot study. Int Immunopharmacol 5:1091-1097


[1] Petersen C & Round JL (2014) Defining dysbiosis and its influence on host immunity and disease. Cell Microbiol 16(7):1024-1033


[1] Petersen C & Round JL (2014) Defining dysbiosis and its influence on host immunity and disease. Cell Microbiol 16(7):1024-1033
[1] Conlon MA & Bird AR (2015) The Impact of Diet and Lifestyle on Gut Microbiota and Human Health. Nutrients 7(1):17-44


August 2017


Am J Clin Nutr. 2017 Jul 5. pii: ajcn138693. doi: 10.3945/ajcn.116.138693. [Epub ahead of print]. Daily supplementation with 15 μg vitamin D2 compared with vitamin D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: a 12-wk randomized, placebo-controlled food-fortification trial.

Tripkovic L1, Wilson LR2, Hart K2, Johnsen S3, de Lusignan S4, Smith CP5, Bucca G5, Penson S6, Chope G6, Elliott R2, Hyppönen E7, Berry JL8, Lanham-New SA2.


Frontiers in Aging Neuroscience 2017; 9 : 168. Neuroprotective and Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants. Muhammad Ayaz, Abdul Sadiq, Muhammad Junaid, Farhat Ullah, Fazal Subhan, Jawad Ahmed. PMID: 28611658.

Osada H, Okamoto T, Kawashima H, Toda, E, Miyake S, Nagai N, et al. (2017) Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina. PLoS ONE 12(6): e0178627.

Kirsten E. Bell, Tim Snijders, Michael Zulyniak, Dinesh Kumbhare, Gianni Parise, Adrian Chabowski, Stuart M. Phillips. A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial. PLOSONE, 2017; 12 (7): e0181387 DOI: 10.1371/journal.pone.0181387.

Timothy J. Wilt, Karen M. Jones, Michael J. Barry, Gerald L. Andriole, Daniel Culkin, Thomas Wheeler, William J. Aronson, Michael K. Brawer. Follow-up of Prostatectomy versus Observation for Early Prostate Cancer. New England Journal of Medicine, 2017; 377 (2): 132 DOI: 10.1056/NEJMoa1615869.

Meghan B. Azad, Ahmed M. Abou-Setta, Bhupendrasinh F. Chauhan, Rasheda Rabbani, Justin Lys, Leslie Copstein, Amrinder Mann, Maya M. Jeyaraman, Ashleigh E. Reid, Michelle Fiander, Dylan S. MacKay, Jon McGavock, Brandy Wicklow, Ryan Zarychanski. Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. Canadian Medical Association Journal, 2017; 189 (28): E929 DOI: 10.1503/cmaj.161390

Rebecca Spain, Katherine Powers, Charles Murchison, Elizabeth Heriza, Kimberly Winges, Vijayshree Yadav, Michelle Cameron, Ed Kim, Fay Horak, Jack Simon, Dennis Bourdette. Lipoic acid in secondary progressive MS. Neurology – Neuroimmunology Neuroinflammation, 2017; 4 (5): e374 DOI: 10.1212/NXI.0000000000000374

BEN BROWN endotoxin

  1. Laveti D, Kumar M, Hemalatha R, Sistla R, Naidu VG, Talla V, Verma V, Kaur N, Nagpal R. Anti-inflammatory treatments for chronic diseases: a review. Inflamm Allergy Drug Targets. 2013 Oct;12(5):349-61.
  2. Saad MJ, Santos A, Prada PO. Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance. Physiology (Bethesda). 2016 Jul;31(4):283-93.
  3. Minihane AM, Vinoy S, Russell WR, Baka A, Roche HM, Tuohy KM, Teeling JL, Blaak EE, Fenech M, Vauzour D, McArdle HJ, Kremer BH, Sterkman L, Vafeiadou K, Benedetti MM, Williams CM, Calder PC. Low-grade inflammation, diet composition and health: current research evidence and its translation. Br J Nutr. 2015 Oct 14;114(7):999-1012.
  4. Calder PC, Albers R, Antoine JM, et al. Inflammatory disease processes and interactions with nutrition. Br J Nutr. 2009 May;101 Suppl 1:S1-45.
  5. Bischoff SC, Barbara G, Buurman W, Ockhuizen T, Schulzke JD, Serino M, Tilg H, Watson A, Wells JM. Intestinal permeability–a new target for disease prevention and therapy. BMC Gastroenterol. 2014 Nov 18;14:189.
  6. Erridge C, Duncan SH, Bereswill S, Heimesaat MM. The induction of colitis and ileitis in mice is associated with marked increases in intestinal concentrations of stimulants of TLRs 2, 4, and 5. PLoS ONE 2010;5:e9125.
  7. Erridge C. The capacity of foodstuffs to induce innate immune activation of human monocytes in vitro is dependent on food content of stimulants of Toll-like receptors 2 and 4. Br J Nutr. 2011 Jan;105(1):15-23.
  8. Erridge C. Stimulants of Toll-like receptor (TLR)-2 and TLR-4 are abundant in certain minimally-processed vegetables. Food Chem Toxicol. 2011 Jun;49(6):1464-7.
  9. Erridge C. Diet, commensals and the intestine as sources of pathogen-associated molecular patterns in atherosclerosis, type 2 diabetes and non-alcoholic fatty liver disease. Atherosclerosis. 2011 May;216(1):1-6.
  10. Herieka M, Faraj TA, Erridge C. Reduced dietary intake of pro-inflammatory Toll-like receptor stimulants favourably modifies markers of cardiometabolic risk in healthy men. Nutr Metab Cardiovasc Dis. 2016 Mar;26(3):194-200.

Endotoxin and atherosclerosis (Simon Martin)

  1. Clett Erridge, Teresa Attina, Corinne M Spickett and David J Webb. A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation. Am J Clin Nutr 2007, 86 (5):1286-92. Online at
    2. Swaroop Pendyala, Jeanne M. Walker, and Peter R. Holt

A High-Fat Diet Is Associated With Endotoxemia That Originates From the Gut.

Gastroenterology. 2012 May; 142(5): 1100–1101.e2.

Published online 2012 Feb 8. doi:  10.1053/j.gastro.2012.01.034

Ice Man
M. Kox, L. T. van Eijk, J. Zwaag, J. van den Wildenberg, F. C. G. J. Sweep, J. G. van der Hoeven, P. Pickkers. Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans. Proceedings of the National Academy of Sciences, 2014; DOI: 10.1073/pnas.1322174111

SIMON MILLS – Cinnamon

  1. Dalby, A (2000). Dangerous Tastes: The Story of Spices.  British Library, London.
  2. Vincent, W (1800) The Periplus of the Erythrean Sea: Part the First. London
  3. He ZD, Qiao CF Han QB et al (2005). Authentication and quantitative analysis on the chemical profile of cassia bark (cortex cinnamomi) by high-pressure liquid chromatography. J Agric Food Chem vol 53, no 7, pp 2424-8
  4. EFSA (European Food Safety Authority) (2008) Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC): Question No EFSA-Q-2008-677. “Coumarin in flavourings and other food ingredients with flavouring properties”. The EFSA Journal, vol 793, pp 1-15
  5. Crawford P, Thai C, Obholz J, et al (2016) Assessment of the effect of lIfestyle intervention plus water-soluble cinnamon extract on lowering blood glucose in pre-diabetics, a randomized, double-blind, multicenter, placebo controlled trial: study protocol for a randomized controlled trial. vol 5, no 17,p 9
  6. Zhang Z, Ye F, Wiseman N, and Mitchell, C (1999). Shang Han Lun: On Cold Damage, Translation and Commentaries. Paradigm Publications
  7. Ravindran PN, Nirmal-Babu K, Shylaja M eds (2005) Cinnamon and Cassia: The Genus Cinnamomum. CRC Press
  8. Perry LM (1980) Medicinal plants of East and Southeast Asia: attributed properties and uses. MIT Press

EFA research

Aram Asatryan, Nicolas G. Bazan. Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection. Journal of Biological Chemistry, 2017; jbc.R117.783076 DOI: 10.1074/jbc.R117.783076

Daniel R. McDougle, Josephine E. Watson, Amr A. Abdeen, Reheman Adili, Megan P. Caputo, John E. Krapf, Rodney W. Johnson, Kristopher A. Kilian, Michael Holinstat, Aditi Das. Anti-inflammatory ω-3 endocannabinoid epoxides. Proceedings of the National Academy of Sciences, 2017; 201610325 DOI: 10.1073/pnas.1610325114

Abdo Alnabulsi et al. The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance, British Journal of Cancer (2017). DOI: 10.1038/bjc.2017.135

Jana Trebatická, et al. Emulsified omega-3 fatty-acids modulate the symptoms of depressive disorder in children and adolescents: a pilot study. Child and Adolescent Psychiatry and Mental Health201711:30. DOI: 10.1186/s13034-017-0167-2. Online at

Benjamin J. Andreone, Brian Wai Chow, Aleksandra Tata, Baptiste Lacoste, Ayal Ben-Zvi, Kevin Bullock, Amy A. Deik, David D. Ginty, Clary B. Clish, Chenghua Gu. Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. Neuron, 2017; 94 (3): 581 DOI: 10.1016/j.neuron.2017.03.043


Victoria A. Acosta-Rodríguez, Marleen H.M. de Groot, Filipa Rijo-Ferreira, Carla B. Green, Joseph S. Takahashi. Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System. Cell Metabolism, 2017; 26 (1): 267 DOI: 10.1016/j.cmet.2017.06.007

Chen-Song Zhang, Simon A. Hawley, Yue Zong, Mengqi Li, Zhichao Wang, Alexander Gray, Teng Ma, Jiwen Cui, Jin-Wei Feng, Mingjiang Zhu, Yu-Qing Wu, Terytty Yang Li, Zhiyun Ye, Shu-Yong Lin, Huiyong Yin, Hai-Long Piao, D. Grahame Hardie, Sheng-Cai Lin. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature, 2017; DOI: 10.1038/nature23275.


Jeffrey Lienert, Christopher Steven Marcum, John Finney, Felix Reed-Tsochas, Laura Koehly. Social influence on 5-year survival in a longitudinal chemotherapy ward co-presence network. Network Science, 2017; 1 DOI: 10.1017/nws.2017.16

Colter Mitchell, Sara McLanahan, Lisa Schneper, Irv Garfinkel, Jeanne Brooks-Gunn, Daniel Notterman. Father Loss and Child Telomere Length. Pediatrics, 2017; e20163245 DOI: 10.1542/peds.2016-3245.

Alexander L. Carlson, Kai Xia, M. Andrea Azcarate-Peril, Barbara D. Goldman, Mihye Ahn, Martin A. Styner, Amanda L. Thompson, Xiujuan Geng, John H. Gilmore, Rebecca C. Knickmeyer. Infant Gut Microbiome Associated with Cognitive Development. Biological Psychiatry, 2017; DOI: 10.1016/j.biopsych.2017.06.021.

David C. Emery, Deborah K. Shoemark, Tom E. Batstone, Christy M. Waterfall, Jane A. Coghill, Tanya L. Cerajewska, Maria Davies, Nicola X. West, Shelley J. Allen. 16S rRNA Next Generation Sequencing Analysis Shows Bacteria in Alzheimer’s Post-Mortem Brain. Frontiers in Aging Neuroscience, 2017; 9 DOI: 10.3389/fnagi.2017.00195

July 2017


Marc M Cohen, De Villiers Smit, Nick Andrianopoulos, Michael Ben-Meir, David McD Taylor, Shefton J Parker, Chalie C Xue, Peter A Cameron. Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non-inferiority trial. The Medical Journal of Australia, 2017; 206 (11): 494 DOI: 10.5694/mja16.00771

Annika S. Axelsson et al. Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes. Science Translational Medicine, 2017 DOI: 10.1126/scitranslmed.aah4477

Daniel G. Amen, William S. Harris, Parris M. Kidd, Somayeh Meysami, and Cyrus A. Raji. Quantitative Erythrocyte Omega-3 EPA Plus DHA Levels Are Related to Higher Regional Cerebral Blood Flow on Brain SPECT. Journal of Alzheimer’s Disease, May 2017 DOI: 10.3233/JAD-17028

Higher Antioxidant Activity, Total Flavonols, and Specific Quercetin Glucosides in Two Different Onion (Allium cepa L.) Varieties Grown under Organic Production: Results from a 6-Year Field Study. Feiyue Ren Kim Reilly, Joseph P. Kerry, Michael Gaffney, Mohammad Hossain, and Dilip K. Rai

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Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association. Frank M. Sacks, Alice H. Lichtenstein, Jason H.Y. Wu, Lawrence J. Appel, Mark A. Creager, Penny M. Kris-Etherton, Michael Miller, Eric B. Rimm, Lawrence L. Rudel, Jennifer G. Robinson, Neil J. Stone, Linda V. Van Horn, On behalf of the American Heart Association.

Circulation. 2017; originally published June 15, 2017.

“Study Confirms: Trans Fats Policy Killed Millions”:


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2.Vindigni SM, Zisman TL, Suskind DL, Damman CJ. The intestinal microbiome,  barrier function, and immune system in inflammatory bowel disease: a tripartite pathophysiological circuit with implications for new therapeutic directions. Therap Adv Gastroenterol. 2016 Jul;9(4):606-25

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Garner Thomson

Kelley JM et al. The Influence of the Patient-Clinician Relationship on Healthcare Outcomes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. PLOS ONE 2014, 9(6): e101191.

Pennebaker, James W (2013) The Secret Life of Pronouns: What Your Words Say About You. New York: Bloomsbury Publishing.


Eur J Appl Physiol. 2017 Feb;117(2):247-254. doi: 10.1007/s00421-016-3512-x. Epub 2016 Dec 24. Cardiovascular function during supine rest in endurance-trained males with New Zealand blackcurrant: a dose-response study.

Cook MD, Myers SD, Gault ML, Edwards VC, Willems ME.

Nutrients. 2017 May 29;9(6). pii: E556. doi: 10.3390/nu9060556.

Blackcurrant Alters Physiological Responses and Femoral Artery Diameter during Sustained Isometric Contraction. Cook MD, Myers SD, Gault ML, Willems MET.

Br J Nutr. 2015 Jun 14;113(11):1697-703. doi: 10.1017/S0007114515001105. Epub 2015 Apr 22. Polyphenol-rich blackcurrant extract exerts hypocholesterolaemic and hypoglycaemic effects in mice fed a diet containing high fat and cholesterol.

Benn T, Kim B, Park YK, Yang Y, Pham TX, Ku CS, Farruggia C, Harness E, Smyth JA, Lee JY.

Ranjit Kumar, Nengjun Yi, Degui Zhi, Peter Eipers, Kelly T. Goldsmith, Paula Dixon, David K. Crossman, Michael R. Crowley, Elliot J. Lefkowitz, J. Martin Rodriguez, Casey D. Morrow. Identification of donor microbe species that colonize and persist long term in the recipient after faecal transplant for recurrent Clostridium difficile. npj Biofilms and Microbiomes, 2017; 3 (1) DOI: 10.1038/s41522-017-0020-7

Alissa C. Nicolucci, Megan P. Hume, Inés Martínez, Shyamchand Mayengbam, Jens Walter, Raylene A. Reimer. Prebiotic Reduces Body Fat and Alters Intestinal Microbiota in Children With Overweight or Obesity. Gastroenterology, 2017; DOI: 10.1053/j.gastro.2017.05.055.

Becattini et al. Commensal microbes provide first line defense against Listeria monocytogenes infection. J. Exp. Med, 2017 DOI: 10.1084/jem.20170495

Hao Wu, Eduardo Esteve, Valentina Tremaroli, Muhammad Tanweer Khan, Robert Caesar, Louise Mannerås-Holm, Marcus Ståhlman, Lisa M Olsson, Matteo Serino, Mercè Planas-Fèlix, Gemma Xifra, Josep M Mercader, David Torrents, Rémy Burcelin, Wifredo Ricart, Rosie Perkins, José Manuel Fernàndez-Real, Fredrik Bäckhed. Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug. Nature Medicine, 2017; DOI: 10.1038/nm.4345

Zehra Esra Ilhan, John K DiBaise, Nancy G Isern, David W Hoyt, Andrew K Marcus, Dae-Wook Kang, Michael D Crowell, Bruce E Rittmann, Rosa Krajmalnik-Brown. Distinctive microbiomes and metabolites linked with weight loss after gastric bypass, but not gastric banding. The ISME Journal, 2017; DOI: 10.1038/ismej.2017.71

The Gut Microbiota and Autism Spectrum Disorders. Front Cell Neurosci. 2017; 11: 120. Published online 2017 Apr 28. doi:  10.3389/fncel.2017.00120

PMCID: PMC5408485. Qinrui Li,1 Ying Han,1,* Angel Belle C. Dy,2 and Randi J. Hagerman.

Free online at:

Dr David Perlmutter comments from: Autism and Gut Bacteria – Hope Moving Forward at

Buffington et al. Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring. Cell, 2016 DOI: 10.1016/j.cell.2016.06.001


German New Medicine:

Dr Gilbert Renaud:

Dr Bruce Lipton:


Irene Roncero-Ramos, Mónica Mendiola-Lanao, Margarita Pérez-Clavijo, Cristina Delgado-Andrade. Effect of different cooking methods on nutritional value and antioxidant activity of cultivated mushrooms. International Journal of Food Sciences and Nutrition, 2016; 68 (3): 287 DOI: 10.1080/09637486.2016.1244662

Microglia-dependent synapse loss in type I interferon-mediated lupus. Allison R. Bialas et al. Nature 2017, doi:10.1038/nature22821.

Stefan Amisten, Israa Mohammad Al-Amily, Arvind Soni, Ross Hawkes, Patricio Atanes, Shanta Jean Persaud, Patrik Rorsman, Albert Salehi. Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells. Endocrine Journal, 2017; 64 (3): 325 DOI: 10.1507/endocrj.EJ16-0338

Omowunmi Aibana, Molly F. Franke, Chuan-Chin Huang, Jerome T. Galea, Roger Calderon, Zibiao Zhang, Mercedes C. Becerra, Emily R. Smith, Alayne G. Ronnenberg, Carmen Contreras, Rosa Yataco, Leonid Lecca, Megan B. Murray. Impact of Vitamin A and Carotenoids on the Risk of Tuberculosis Progression. Clinical Infectious Diseases, 2017; DOI: 10.1093/cid/cix476

Kaixiong Ye, Feng Gao, David Wang, Ofer Bar-Yosef, Alon Keinan. Dietary adaptation of FADS genes in Europe varied across time and geography. Nature Ecology & Evolution, 2017; 1: 0167 DOI: 10.1038/s41559-017-0167

Santosh Kumar, Angela Downie Ruiz Velasco, Gracjan Michlewski. Oleic Acid Induces MiR-7 Processing through Remodeling of Pri-MiR-7/Protein Complex. Journal of Molecular Biology, 2017; 429 (11): 1638 DOI: 10.1016/j.jmb.2017.05.001

Weronica E. Ek, Elmar W. Tobi, Muhammad Ahsan, Erik Lampa, Erica Ponzi, Soterios A. Kyrtopoulos, Panagiotis Georgiadis, L.H Lumey, Bastiaan T. Heijmans, Maria Botsivali, Ingvar A. Bergdahl, Torgny Karlsson, Mathias Rask-Andersen, Domenico Palli, Erik Ingelsson, Åsa K. Hedman, Lena M. Nilsson, Paolo Vineis, Lars Lind, James M. Flanagan, Åsa Johansson. Tea and coffee consumption in relation to DNA methylation in four European cohorts. Human Molecular Genetics, 2017; DOI: 10.1093/hmg/ddx194

L Pizzuti et al. GLUT 1 receptor expression and circulating levels of fasting glucose in high grade serous ovarian cancer. Journal of Cell Physiology, May 2017 DOI: 10.1002/jcp.26023

Marta K. Zamroziewicz, Erick J. Paul, Chris E. Zwilling, Aron K. Barbey. Determinants of fluid intelligence in healthy aging: Omega-3 polyunsaturated fatty acid status and frontoparietal cortex structure. Nutritional Neuroscience, 2017; 1 DOI: 10.1080/1028415X.2017.1324357



June 2017

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Rohit Loomba, Victor Seguritan, Weizhong Li, Tao Long, Niels Klitgord, Archana Bhatt, Parambir Singh Dulai, Cyrielle Caussy, Richele Bettencourt, Sarah K. Highlander, Marcus B. Jones, Claude B. Sirlin, Bernd Schnabl, Lauren Brinkac, Nicholas Schork, Chi-Hua Chen, David A. Brenner, William Biggs, Shibu Yooseph, J. Craig Venter, Karen E. Nelson. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Cell Metabolism, 2017; 25 (5): 1054 DOI: 10.1016/j.cmet.2017.04.001.

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Eveliina Munukka, Anniina Rintala, Raine Toivonen, Matts Nylund, Baoru Yang, Anna Takanen, Arno Hänninen, Jaana Vuopio, Pentti Huovinen, Sirpa Jalkanen, Satu Pekkala. Faecalibacterium prausnitzii treatment improves hepatic health and reduces adipose tissue inflammation in high-fat fed mice. The ISME Journal, 2017; DOI: 10.1038/ismej.2017.24

Joshua D. Schoenfeld, et al. O 2 − and H 2 O 2 -Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. Cancer Cell, 2017; DOI: 10.1016/j.ccell.2017.02.018

April 2017

IHCAN April references



Jia Zhong et al. B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial. PNAS 2017 ; published ahead of print March 13, 2017,

HELEN MONK on BANT Supervision

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Gloria Bonuccelli, Ernestina Marianna De Francesco, Rianne de Boer, Herbert B. Tanowitz, Michael P. Lisanti. NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Identification of Vitamin C and CAPE as natural products targeting “stemness”. Oncotarget, 2015; DOI: 10.18632/oncotarget.15400.

Hillard Kaplan, Randall C Thompson, Benjamin C Trumble, L Samuel Wann, Adel H Allam, Bret Beheim, Bruno Frohlich, M Linda Sutherland, James D Sutherland, Jonathan Stieglitz, Daniel Eid Rodriguez, David E Michalik, Chris J Rowan, Guido P Lombardi, Ram Bedi, Angela R Garcia, James K Min, Jagat Narula, Caleb E Finch, Michael Gurven, Gregory S Thomas. Coronary atherosclerosis in indigenous South American Tsimane: a cross-sectional cohort study. The Lancet, 2017; DOI: 10.1016/S0140-6736(17)30752-3.

Mark Jones, Susan Tett, Geeske M. E. E. Peeters, Gita D. Mishra, Annette Dobson. New-Onset Diabetes After Statin Exposure in Elderly Women: The Australian Longitudinal Study on Women’s Health. Drugs & Aging, 2017; 34 (3): 203 DOI: 10.1007/s40266-017-0435-0.

Emma Lefrançais, Guadalupe Ortiz-Muñoz, Axelle Caudrillier, Beñat Mallavia, Fengchun Liu, David M. Sayah, Emily E. Thornton, Mark B. Headley, Tovo David, Shaun R. Coughlin, Matthew F. Krummel, Andrew D. Leavitt, Emmanuelle Passegué, Mark R. Looney. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature, 2017; DOI: 10.1038/nature21706

Didier Ndeh, Artur Rogowski, Alan Cartmell, Ana S. Luis, Arnaud Baslé, Joseph Gray, Immacolata Venditto, Jonathon Briggs, Xiaoyang Zhang, Aurore Labourel, Nicolas Terrapon, Fanny Buffetto, Sergey Nepogodiev, Yao Xiao, Robert A. Field, Yanping Zhu, Malcolm A. O’Neill, Breeanna R. Urbanowicz, William S. York, Gideon J. Davies, D. Wade Abbott, Marie-Christine Ralet, Eric C. Martens, Bernard Henrissat, Harry J. Gilbert. Complex pectin metabolism by gut bacteria reveals novel catalytic functions. Nature, 2017; DOI: 10.1038/nature21725.

Simon Nicolas, Vincent Blasco‐Baque, Audren Fournel, Jerome Gilleron, Pascale Klopp, Aurelie Waget, Franck Ceppo, Alysson Marlin, Roshan Padmanabhan, Jason S Iacovoni, François Tercé, Patrice D Cani, Jean‐François Tanti, Remy Burcelin, Claude Knauf, Mireille Cormont, Matteo Serino. Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism. Molecular Systems Biology, 2017; 13 (3): 921 DOI: 10.15252/msb.20167356

Stuart G. Snowden, Amera A. Ebshiana, Abdul Hye, Yang An, Olga Pletnikova, Richard O’Brien, John Troncoso, Cristina Legido-Quigley, Madhav Thambisetty. Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study. PLOS Medicine, 2017; 14 (3): e1002266 DOI: 10.1371/journal.pmed.1002266

Stephanie Vuillermot, Wei Luan, Urs Meyer, Darryl Eyles. Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation. Molecular Autism, 2017; 8 (1) DOI: 10.1186/s13229-017-0125-0

Tatiana E. Salazar et al, Electroacupuncture Promotes CNS-Dependent Release of Mesenchymal Stem Cells. STEM CELLS, 2017; DOI: 10.1002/stem.2613

March 2017

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Nicole Paulin, Yvonne Döring, Sander Kooijman, Xavier Blanchet, Joana R. Viola, Renske de Jong, Manuela Mandl, Jeffrey Hendrikse, Maximilian Schiener, Philipp von Hundelshausen, Anja Vogt, Christian Weber, Khalil Bdeir, Susanna M. Hofmann, Patrick C.N. Rensen, Maik Drechsler, Oliver Soehnlein. Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance. EBioMedicine, 2017; DOI: 10.1016/j.ebiom.2017.01.006

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LEARNING ZONE – the Sensitivity Gene

* The January 2015 Duke University study, “Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial,” was published in the Journal of Policy Analysis and Management.
*Benedicte Meyer et al, Maintenance of Chronic Fatigue Syndrome (CFS) in Young CFS Patients Is Associated with the 5-HTTLPR and SNP rs25531 A > G Genotype. PLOS One,  2015,

* Felitti VJ, Anda RF et al. Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults: The Adverse Childhood Experiences (ACE) Study. Am J Preventive Med May 1998, 14, 4,: 245–58.

* For The Sensitivity Hypothesis, Dandelion and Orchid Children, see research by Bruce Ellis  University of Arizona, and W Thomas Boyce  University of British Columbia, for example “Biological sensitivity to context: I. An evolutionary–developmental theory of the origins and functions of stress reactivity” in Development and Psychopathology

17, 2005, 271–301. DOI: 10.1017/S095457940505014.

* Childhood Disrupted: How Your Biography Becomes Your Biology and How You Can Heal, by Donna Jackson Nakazawa:

* GSC – Genetically Sensitive Client- Chrysalis Effect Specialist Practitioner Training Elaine Wilkins:


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A Meta-Analysis of Randomized Controlled Trials and Prospective Cohort Studies of Eicosapentaenoic and Docosahexaenoic Long-Chain Omega-3 Fatty Acids and Coronary Heart Disease Risk. Dominik D. Alexander et al. Open Access . DOI:

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Additional story:
Antonio Gonzalez, Embriette Hyde, Naseer Sangwan, Jack A. Gilbert, Erik Viirre, Rob Knight. Migraines Are Correlated with Higher Levels of Nitrate-, Nitrite-, and Nitric Oxide-Reducing Oral Microbes in the American Gut Project Cohort. mSystems, October 2016 DOI: 10.1128/mSystems.00105-16

Nutritional approaches to combat oxidative stress in Alzheimer’s disease. Butterfield D, Castegna A, Pocernich C, Drake J, Scapagnini G, Calabrese V. J Nutr Biochem. 2002 Aug;13(8):444.

Influence of apple polyphenols on inflammatory gene expression. Jung M, Triebel S, Anke T, Richling E, Erkel G. Mol Nutr Food Res. 2009 Oct;53(10):1263-80. doi: 10.1002/mnfr.200800575.

Christopher T. Ford, Siân Richardson, Francis McArdle, Silvina B. Lotito, Alan Crozier, Anne McArdle, Malcolm J. Jackson. Identification of (poly)phenol treatments that modulate the release of pro-inflammatory cytokines by human lymphocytes. British Journal of Nutrition, 2016; 115 (10): 1699 DOI: 10.1017/S0007114516000805

  1. Zamora-Ros, M. Rabassa, A. Cherubini, M. Urpi-Sarda, S. Bandinelli, L. Ferrucci, C. Andres-Lacueva. High Concentrations of a Urinary Biomarker of Polyphenol Intake Are Associated with Decreased Mortality in Older Adults. Journal of Nutrition, 2013; 143 (9): 1445 DOI: 10.3945/jn.113.177121

Harri Hemil. Vitamin E and the risk of pneumonia: using the I²-statistic to quantify heterogeneity within a controlled trial. British Journal of Nutrition, 2016; 1 DOI: 10.1017/S0007114516003408.

Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 – Fields of Precision Nutrition

J Nutrigenet Nutrigenomics 2016;9:12-27, (DOI:10.1159/000445350)

Fulltext PDF (674 Kb) Free Access at


From Sample to Multi-Omics Conclusions in under 48 Hours. Robert A. Quinn, Jose A. Navas-Molina, Embriette R. Hyde, Se Jin Song, Yoshiki Vázquez-Baeza, Greg Humphrey, James Gaffney, Jeremiah J. Minich, Alexey V. Melnik, Jakob Herschend, Jeff DeReus, Austin Durant, Rachel J. Dutton, Mahdieh Khosroheidari, Clifford Green, Ricardo da Silva, Pieter C. Dorrestein, Rob Knight

Jack A. Gilbert, Editor. mSystems, 2016: DOI: 10.1128/mSystems.00038-16.

Timothy R. Sampson et al. Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease. Cell, December 2016 DOI: 10.1016/j.cell.2016.11.018.

Christoph A. Thaiss et al. Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations. Cell, December 2016 DOI: 10.1016/j.cell.2016.11.003

Diet-Microbiome Interactions in Health Are Controlled by Intestinal Nitrogen Source Constraints. Andrew J. Holmes et al. Cell Metabolism. In Press. available online 23 November 2016.

Francesco Foroni, Giulio Pergola, Raffaella Ida Rumiati. Food colour is in the eye of the beholder: the role of human trichromatic vision in food evaluation. Scientific Reports, 2016; 6: 37034 DOI: 10.1038/srep37034

Dagfinn Aune, NaNa Keum, Edward Giovannucci, Lars T. Fadnes, Paolo Boffetta, Darren C. Greenwood, Serena Tonstad, Lars J. Vatten, Elio Riboli, Teresa Norat. Nut consumption and risk of cardiovascular disease, total cancer, all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective studies. BMC Medicine, 2016; 14 (1) DOI: 10.1186/s12916-016-0730-3

  1. Zelano, H. Jiang, G. Zhou, N. Arora, S. Schuele, J. Rosenow, J. A. Gottfried. Nasal Respiration Entrains Human Limbic Oscillations and Modulates Cognitive Function. Journal of Neuroscience, 2016; 36 (49): 12448 DOI: 10.1523/JNEUROSCI.2586-16.2016

* Video:

Candyce H. Kroenke, Yvonne L. Michael, Elizabeth M. Poole, Marilyn L. Kwan, Sarah Nechuta, Eric Leas, Bette J. Caan, John Pierce, Xiao-Ou Shu, Ying Zheng, Wendy Y. Chen. Postdiagnosis social networks and breast cancer mortality in the After Breast Cancer Pooling Project. Cancer, 2016; DOI: 10.1002/cncr.30440.

  1. Gunness, J. Michiels, L. Vanhaecke, S. De Smet, O. Kravchuk, A. Van de Meene, M. J. Gidley. Reduction in circulating bile acid and restricted diffusion across the intestinal epithelium are associated with a decrease in blood cholesterol in the presence of oat  -glucan. The FASEB Journal, 2016; 30 (12): 4227 DOI: 10.1096/fj.201600465R.

Inmaculada Moreno, Francisco M. Codoñer, Felipe Vilella, Diana Valbuena, Juan F. Martinez-Blanch, Jorge Jimenez-Almazán, Roberto Alonso, Pilar Alamá, Jose Remohí, Antonio Pellicer, Daniel Ramon, Carlos Simon. Evidence that the endometrial microbiota has an effect on implantation success or failure. American Journal of Obstetrics and Gynecology, 2016; 215 (6): 684 DOI: 10.1016/j.ajog.2016.09.075

Haiqiu Huang, Xiaojing Jiang, Zhenlei Xiao, Lu Yu, Quynhchi Pham, Jianghao Sun, Pei Chen, Wallace Yokoyama, Liangli Lucy Yu, Yaguang Sunny Luo, Thomas T. Y. Wang. Red Cabbage Microgreens Lower Circulating Low-Density Lipoprotein (LDL), Liver Cholesterol, and Inflammatory Cytokines in Mice Fed a High-Fat Diet. Journal of Agricultural and Food Chemistry, 2016; 64 (48): 9161 DOI: 10.1021/acs.jafc.6b03805

December 2016


Giannis Koukkidis, Richard Haigh, Natalie Allcock, Suzanne Jordan, and Primrose Freestone. Salad leaf juices enhance Salmonella growth, fresh produce colonisation and virulence. Applied and Environmental Microbiology, November 2016 DOI: 10.1128/AEM.02416-16
Cheng-Shiuan Lee, Molly E. Lutcavage, Emily Chandler, Daniel J. Madigan, Robert M. Cerrato, Nicholas S. Fisher. Declining Mercury Concentrations in Bluefin Tuna Reflect Reduced Emissions to the North Atlantic Ocean. Environmental Science & Technology, 2016; DOI: 10.1021/acs.est.6b04328

Lei Yin, Kevin Yu, Simon Lin, Xiao Song, Xiaozhong Yu. Associations of blood mercury, inorganic mercury, methyl mercury and bisphenol A with dental surface restorations in the U.S. population, NHANES 2003–2004 and 2010–2012. Ecotoxicology and Environmental Safety, 2016; 134: 213 DOI: 10.1016/j.ecoenv.2016.09.001

Dr Mark Hyman on mercury:


Elmira Akbari, Zatollah Asemi, Reza Daneshvar Kakhaki, Fereshteh Bahmani, Ebrahim Kouchaki, Omid Reza Tamtaji, Gholam Ali Hamidi, Mahmoud Salami. Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer’s Disease: A Randomized, Double-Blind and Controlled Trial. Frontiers in Aging Neuroscience, 2016; 8 DOI: 10.3389/fnagi.2016.00256

BEN BROWN Migraine

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E. F. G. Naninck, J. E. Oosterink, K.-Y. Yam, L. P. de Vries, H. Schierbeek, J. B. van Goudoever, R.-N. Verkaik-Schakel, J. A. Plantinga, T. Plosch, P. J. Lucassen, A. Korosi. Early micronutrient supplementation protects against early stress-induced cognitive impairments. The FASEB Journal, 2016; DOI: 10.1096/fj.201600834R

Sarkar et al. Psychobiotics and the Manipulation of Bacteria-Brain Signals. Trends in Neurosciences, October 2016 DOI: 10.1016/j.tins.2016.09.002


PLoS One. 2016 Oct 31;11(10):e0165378. doi: 10.1371/journal.pone.0165378. eCollection 2016. Third Exposure to a Reduced Carbohydrate Meal Lowers Evening Postprandial Insulin and GIP Responses and HOMA-IR Estimate of Insulin Resistance. Lin PJ1, Borer KT1.

Giles Major et al. Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-related Symptoms in Individuals with Irritable Bowel Syndrome, Gastroenterology (2016). DOI: 10.1053/j.gastro.2016.09.062

  1. Pegorie, D.W. Denning, W. Welfare. Estimating the burden of invasive and serious fungal disease in the United Kingdom. Journal of Infection, 2016; DOI: 10.1016/j.jinf.2016.10.005
  1. Ren, C. Luo, Y. Feng, X. Yao, Z. Shi, F. Liang, J. X. Kang, J.-B. Wan, Z. Pei, H. Su. Omega-3 polyunsaturated fatty acids promote amyloid-  clearance from the brain through mediating the function of the glymphatic system. The FASEB Journal, 2016; DOI: 10.1096/fj.201600896
  2. Yuan, G. Wei, Y. You, Y. Huang, H. J. Lee, M. Dong, J. Lin, T. Hu, H. Zhang, C. Zhang, H. Zhou, R. Ye, X. Qi, B. Zhai, W. Huang, S. Liu, W. Xie, Q. Liu, X. Liu, C. Cui, D. Li, J. Zhan, J. Cheng, Z. Yuan, W. Jin. Rutin ameliorates obesity through brown fat activation. The FASEB Journal, 2016; DOI: 10.1096/fj.201600459RR

Harri Hemil�. Vitamin E and the risk of pneumonia: using the I²-statistic to quantify heterogeneity within a controlled trial. British Journal of Nutrition, 2016; 1 DOI: 10.1017/S0007114516003408.

November 2016


Mi-Sung Kim, Sarah A. Krawczyk, Ludivine Doridot, Alan J. Fowler, Jennifer X. Wang, Sunia A. Trauger, Hye-Lim Noh, Hee Joon Kang, John K. Meissen, Matthew Blatnik, Jason K. Kim, Michelle Lai, Mark A. Herman. ChREBP regulates fructose-induced glucose production independently of insulin signaling. Journal of Clinical Investigation, 2016; DOI: 10.1172/JCI81993

Zaidi et al. Vitamin D Deficiency in Medical Inpatients: A Retrospective Study of Implications of Untreated Versus Treated Deficiency. Nutrition and Metabolic Insights 2016:9 65–69 doi:10.4137/NMI.S33747.

Ryan Hutchinson, Abdulhadi Akhtar, Justin Haridas, Deepa Bhat, Claus Roehrborn, Yair Lotan. Testing and referral patterns in the years surrounding the US Preventive Services Task Force recommendation against prostate-specific antigen screening. Cancer, 2016; DOI: 10.1002/cncr.30330

Agatha A. van der Klaauw, Julia M. Keogh, Elana Henning, Cheryl Stephenson, Sarah Kelway, Victoria M. Trowse, Naresh Subramanian, Stephen O’Rahilly, Paul C. Fletcher, I. Sadaf Farooqi. Divergent effects of central melanocortin signalling on fat and sucrose preference in humans. Nature Communications, 2016; 7: 13055 DOI: 10.1038/NCOMMS13055

* Denis Campbell10/20/2016.


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4.             Kou MC, Chiou SY, Weng CY, Wang L, Ho CT, Wu MJ. Curcuminoids distinctly exhibit antioxidant activities and regulate expression of scavenger receptors and heme oxygenase-1. Mol Nutr Food Res. 2013 Sep;57(9):1598-610.

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6.             Guo LY, Cai XF, Lee JJ, Kang SS, Shin EM, Zhou HY, Jung JW, Kim YS. Comparison of suppressive effects of demethoxycurcumin and bisdemethoxycurcumin on expressions of inflammatory mediators in vitro and in vivo. Arch Pharm Res. 2008  Apr;31(4):490-6.

  1. Aggarwal BB, Yuan W, Li S, Gupta SC. Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric. Mol Nutr Food Res. 2013 Sep;57(9):1529-42.

8.             Madhu K, Chanda K, Saji MJ. Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial. Inflammopharmacology. 2013 Apr;21(2):129-36.9.             Metzler M, Pfeiffer E, Schulz SI, Dempe JS. Curcumin uptake and metabolism. Biofactors. 2013 Jan-Feb;39(1):14-20.10.         Wang K, Qiu F. Curcuminoid metabolism and its contribution to the pharmacological effects. Curr Drug Metab. 2013 Sep;14(7):791-806.

  1. Shen L, Liu CC, An CY, Ji HF. How does curcumin work with poor bioavailability? Clues from experimental and theoretical studies. Sci Rep. 2016 Feb 18;6:20872.
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  1. Al-Karawi D, Al Mamoori DA, Tayyar Y. The Role of Curcumin Administration in Patients with Major Depressive Disorder: Mini Meta-Analysis of Clinical Trials.Phytother Res. 2016 Feb;30(2):175-83.
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17.         Hanai H, Iida T, Takeuchi K, et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. 2006 Dec;4(12):1502-6.18.         Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, et al. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014 Mar 20;9:451-819.         Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. 2012 Nov;35(11):2121-7. doi: 10.2337/dc12-0116.

  1. Curcumin attenuates severity of premenstrual syndrome symptoms: A randomized, double-blind, placebo-controlled trial

21.         Hishikawa N, Takahashi Y, Amakusa Y, Tanno Y, Tuji Y, Niwa H, Murakami N, Krishna UK. Effects of turmeric on Alzheimer’s disease with behavioral and psychological symptoms of dementia. Ayu. 2012 Oct;33(4):499-504.




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[2] Ivanov II, & Littman DR (2010). Segmented filamentous bacteria take the stage. Mucosal immunology, 3 (3), 209-12 PMID: 20147894

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Milda Stuknytė, Margherita Maggioni, Stefano Cattaneo, Paola De Luca, Amelia Fiorilli, Anita Ferraretto, Ivano De Noni. Release of wheat gluten exorphins A5 and C5 during in vitro gastrointestinal digestion of bread and pasta and their absorption through an in vitro model of intestinal epithelium. Food Research International, 2015; 72: 208 DOI: 10.1016/j.foodres.2015.04.002.

Matthew Weiser, Jeremy M Simon, Bharati Kochar, Adelaide Tovar, Jennifer W Israel, Adam Robinson, Gregory R Gipson, Matthew S Schaner, Hans H Herfarth, R Balfour Sartor, Dermot P B McGovern, Reza Rahbar, Timothy S Sadiq, Mark J Koruda, Terrence S Furey, Shehzad Z Sheikh. Molecular classification of Crohn’s disease reveals two clinically relevant subtypes. Gut, October 2016 DOI: 10.1136/gutjnl-2016-312518.

Antonio Gonzalez, Embriette Hyde, Naseer Sangwan, Jack A. Gilbert, Erik Viirre, Rob Knight. Migraines Are Correlated with Higher Levels of Nitrate-, Nitrite-, and Nitric Oxide-Reducing Oral Microbes in the American Gut Project Cohort. mSystems, October 2016 DOI: 10.1128/mSystems.00105-16.




Turmeric tea study:
Dias, I., Ademowo, O., Newey, E. and Griffiths, H. (2015). The Nrf2-ARE activation protect neurones against oxidative stress. Free Radical Biology and Medicine, 86, pp.S30-S31.
Hawkey, C. (2001). COX-1 and COX-2 inhibitors. Best Practice & Research Clinical Gastroenterology, 15(5), pp.801-820.
Lee, J. (2005). Nrf2, a multi-organ protector? The FASEB Journal, 19(9), pp.1061-1066.
Aggarwal B.B, Ichikawa H., Garodia P., Weerasinghe P., Sethi G., Bhatt I.D., Pandey M.K., Shishodia S., Nair M.G. From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer. Expert Opin Ther Targets 2006;10(1):87-118.
Aggarwal B.B., Sundaram C., Malani N., Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol. 2007;595:1-75.
Aggarwal B.B., Yuan W., Li S., Gupta S.C. Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric. Mol Nutr Food Res. 2013;57(9):1529-42.
Potential role of herbal remedies in stem cell therapy: proliferation and differentiation of human mesenchymal stromal cells. Vindya Lankika Udalamaththa, Chanika Dilumi Jayasinghe and Preethi Vidya Udagama. Stem Cell Research & Therapy2016,7:110. DOI: 10.1186/s13287-016-0366-4.

L.N. Yelland, B.J. Gajewski, J. Colombo, R.A. Gibson, M. Makrides, S.E. Carlson. Predicting the effect of maternal docosahexaenoic acid (DHA) supplementation to reduce early preterm birth in Australia and the United States using results of within country randomized controlled trials. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2016; 112: 44 DOI: 10.1016/j.plefa.2016.08.007

Cherrie L. Small, Lydia Xing, Joseph B. McPhee, Hong T. Law, Brian K. Coombes. Acute Infectious Gastroenteritis Potentiates a Crohn’s Disease Pathobiont to Fuel Ongoing Inflammation in the Post-Infectious Period. PLOS Pathogens, 2016; 12 (10): e1005907 DOI: 10.1371/journal.ppat.1005907

Malgorzata Dobosz-Bartoszek, Mark H. Pinkerton, Zbyszek Otwinowski, Srinivas Chakravarthy, Dieter Söll, Paul R. Copeland, Miljan Simonović. Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation. Nature Communications, 2016; 7: 12941 DOI: 10.1038/ncomms12941

Shu G. Chen, Vilius Stribinskis, Madhavi J. Rane, Donald R. Demuth, Evelyne Gozal, Andrew M. Roberts, Rekha Jagadapillai, Ruolan Liu, Kyonghwan Choe, Bhooma Shivakumar, Francheska Son, Shunying Jin, Richard Kerber, Anthony Adame, Eliezer Masliah, Robert P. Friedland. Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans. Scientific Reports, 2016; 6: 34477 DOI: 10.1038/srep34477.

Madhusudana Rao Chikka, Charumathi Anbalagan, Katherine Dvorak, Kyle Dombeck, Veena Prahlad. The Mitochondria-Regulated Immune Pathway Activated in the C. elegans Intestine Is Neuroprotective. Cell Reports, 2016; 16 (9): 2399 DOI: 10.1016/j.celrep.2016.07.077

Shiran Salomon-Zimri, Micaela Johanna Glat, Yael Barhum, Ishai Luz, Anat Boehm-Cagan, Ori Liraz, Tali Ben-Zur, Daniel Offen, Daniel M. Michaelson. Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment. Journal of Alzheimer’s Disease, Volume 53, Number 4, 2016; Pages 1443-1458.

Marc A. Mitchell, David D. Wartinger. Validation of a Functional Pyelocalyceal Renal Model for the Evaluation of Renal Calculi Passage While Riding a Roller Coaster. The Journal of the American Osteopathic Association, 2016; 116 (10): 647 DOI: 10.7556/jaoa.2016.128

Michelle Beaumont, Julia K. Goodrich, Matthew A. Jackson, Idil Yet, Emily R. Davenport, Sara Vieira-Silva, Justine Debelius, Tess Pallister, Massimo Mangino, Jeroen Raes, Rob Knight, Andrew G. Clark, Ruth E. Ley, Tim D. Spector, Jordana T. Bell. Heritable components of the human fecal microbiome are associated with visceral fat. Genome Biology, 2016; 17 (1) DOI: 10.1186/s13059-016-1052-7.

Joseph P Zackular, Jessica L Moore, Ashley T Jordan, Lillian J Juttukonda, Michael J Noto, Maribeth R Nicholson, Jonathan D Crews, Matthew W Semler, Yaofang Zhang, Lorraine B Ware, M Kay Washington, Walter J Chazin, Richard M Caprioli, Eric P Skaar. Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection. Nature Medicine, 2016; DOI: 10.1038/nm.4174.

Jian Zhen Ou, Jeremy J. Cottrell, Nam Ha, Naresh Pillai, Chu K. Yao, Kyle J. Berean, Stephanie A. Ward, Danilla Grando, Jane G. Muir, Christopher J. Harrison, Udani Wijesiriwardana, Frank R. Dunshea, Peter R. Gibson, Kourosh Kalantar-zadeh. Potential of in vivo real-time gastric gas profiling: a pilot evaluation of heat-stress and modulating dietary cinnamon effect in an animal model. Scientific Reports, 2016; 6: 33387 DOI: 10.1038/srep33387.

Somadina Emineke, Alan J Cooper, Sarah Fouch, Brian R Birch, Bashir A Lwaleed. Diluted honey inhibits biofilm formation: potential application in urinary catheter management? Journal of Clinical Pathology, 2016; jclinpath-2015-203546 DOI: 10.1136/jclinpath-2015-203546




October 2016



2011 PACE paper in The Lancet:
PACE authors’ new analyses:…otocol_based_analysis_final_8th_Sept_2016.pdf.

Robert K. Naviaux et al. Metabolic features of chronic fatigue syndrome. PNAS 2016, vol. 113: 37, E5472–E5480. doi: 10.1073/pnas.1607571113.

Robert K. Naviaux, Metabolic features of the cell danger response. Mitochondrion, Volume 16, May 2014, Pages 7–17.


Castro-Marrero Jesús, Cordero Mario D., Segundo María José, Sáez-Francàs Naia, Calvo Natalia, Román-Malo Lourdes, Aliste Luisa, Fernández de Sevilla Tomás, and Alegre José.

Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in Chronic Fatigue Syndrome? Antioxidants & Redox Signaling. March 10, 2015, 22(8): 679-685. doi:10.1089/ars.2014.6181.

Cannabidiol Reduces The Anxiety Induced By Simulated Public Speaking In Treatment-Naïve Social Phobia Patients”. MM Bergamaschi, Department of Neuroscience and Behavior, School of Medicine of Ribeirão Preto, University of São Paulo, SP, Brazil.

Neuropsychopharmacology, May 2011

“Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing”. P Fusar-Poli, Neuroimaging Section, Division of Psychological Medicine, Institute of Psychiatry, London. Archives of General Psychiatry, January 2009.


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Freddie C. Hamdy, et al. 10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer. New England Journal of Medicine, 2016; DOI: 10.1056/NEJMoa1606220

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Mathias Rask-Andersen, David Martinsson, Muhammad Ahsan, Stefan Enroth, Weronica E Ek, Ulf Gyllensten, Åsa Johansson. Epigenome Wide Association Study Reveals Differential DNA Methylation in Individuals With a History of Myocardial Infarction. Human Molecular Genetics, 2016; ddw302 DOI: 10.1093/hmg/ddw302

Antonios Chronopoulos, Benjamin Robinson, Muge Sarper, Ernesto Cortes, Vera Auernheimer, Dariusz Lachowski, Simon Attwood, Rebeca García, Saba Ghassemi, Ben Fabry, Armando del Río Hernández. ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion. Nature Communications, 2016; 7: 12630 DOI: 10.1038/ncomms12630

Adrian R Martineau, Christopher J Cates, Mitsuyoshi Urashima, Megan Jensen, Alex P Griffiths, Ulugbek Nurmatov, Aziz Sheikh, Chris J Griffiths. Vitamin D for the management of asthma. Cochrane Library, 2016 DOI: 10.1002/14651858.CD011511.pub2.

Nupur Bhattacharya et al. Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8 T Cell-Mediated Immunity in Colorectal Cancer. Immunity, August 2016 DOI: 10.1016/j.immuni.2016.08.008

Stephen P. Juraschek, Allan C. Gelber, Hyon K. Choi, Lawrence J. Appel, Edgar R. Miller. Effects of the Dietary Approaches To Stop Hypertension (DASH) Diet and Sodium Intake on Serum Uric Acid. Arthritis & Rheumatology, 2016; DOI: 10.1002/art.39813


September 2016


Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis . A. Trovato et al. Immunity & Ageing201613:23

DOI: 10.1186/s12979-016-0078-8

Changes in Burnout and Satisfaction With Work-Life Balance in Physicians and the General US Working Population Between 2011 and 2014.

Shanafelt, Tait D. et al. Mayo Clinic Proceedings 2016, Volume 90 , Issue 12 , 1600-13.

Clinical research evidence of cupping therapy in China: a systematic literature review

Huijuan Cao1, Mei Han1, Xun Li1, Shangjuan Dong1, Yongmei Shang1, Qian Wang1, Shu Xu1 and Jianping Liu

BMC Complementary and Alternative MedicineThe official journal of the International Society for Complementary Medicine Research (ISCMR)201010:70

DOI: 10.1186/1472-6882-10-70.
Journal of Traditional Chinese Medical Sciences

Volume 1, Issue 1, 1 July 2014, Pages 49–61. Cupping therapy for acute and chronic pain management: a systematic review of randomized clinical trials

Huijuan Caoa, Xun Lia, Xue Yanb, Nissi S. Wangc, Alan Bensoussand, Jianping Liua, et al. doi:10.1016/j.jtcms.2014.11.003.

Serum and retinal responses to three different doses of macular carotenoids over 12 weeks of supplementation. Experimental Eye Research, Volume 151, October 2016, Pages 1-8.  James M. Stringham, Nicole T. Stringham.

Eleanor Pullenayegum, PhD et al. Live Attenuated Versus Inactivated Influenza Vaccine in Hutterite Children: A Cluster Randomized Blinded Trial. Annals of Internal Medicine, August 2016 DOI: 10.7326/M16-0513.

Bobak Heydari, et al. Effect of Omega-3 Acid Ethyl Esters on Left Ventricular Remodeling After Acute Myocardial InfarctionClinical Perspective. Circulation, 2016; 134 (5): 378 DOI: 10.1161/CIRCULATIONAHA.115.019949

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G J McBean, M G López and F K Wallner. Redox-based therapeutics in neurodegenerative disease. British Journal of Pharmacology, 1 AUG 2016 DOI: 10.1111/bph.13551.

Do You Know The Power of the Nrf2 Pathway?

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The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders. Gao B1, Doan A1, Hybertson BM1. Free online at

Kanwaljit Singh, Susan L. Connors, Eric A. Macklin, Kirby D. Smith, Jed W. Fahey, Paul Talalay, and Andrew W. Zimmerman. Sulforaphane treatment of autism spectrum disorder (ASD). PNAS, October 13, 2014 DOI: 10.1073/pnas.1416940111.

Saskia F. Erttmann, Anetta Hartlova, Marta Sloniecka, Faizal A.M. Raffi, Ava Hosseinzadeh, Tomas Edgren, Reza Rofougaran, Ulrike Resch, Maria Fällman, Torben Ek, and Nelson O. Gekara. Loss of the DNA Damage Repair Kinase ATM Impairs Inflammasome-Dependent Anti-Bacterial Innate Immunity. Immunity, 2016 DOI: 10.1016/j.immuni.2016.06.018.

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Taking a “good” look at free radicals in the aging process

Siegfried Hekimi,* Jérôme Lapointe, and Yang Wen, free online at

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IHCAN Student

  1. Kirby E D et al. Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2. eLife 2013, 2: 1-23.
  2. Cahill L et al. Enhanced human memory consolidation with post-learning stress: interaction with the degree of arousal at encoding. Learn. Mem 2003. 10, 270–274. 10.1101/lm.62403
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Yassine HN, Rawat V, Mack WJ, Quinn JF, Yurko-Mauro K, Bailey-Hall E, Aisen PS, Chui HC, Schneider LS. The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer’s disease. Alzheimers Res Ther. 2016 Jun 30;8:25. PubMed.

K Rosenke et al. Plasmodium parasitemia associated with increased survival in Ebola virus-infected patients. Clinical Infectious Diseases, 2016; DOI: 10.1093/cid/ciw452.

Carlos Celis-Morales, et al Effect of personalized nutrition on health-related behaviour change: evidence from the Food4me European randomized controlled trial. International Journal of Epidemiology, 2016; dyw186 DOI: 10.1093/ije/dyw186

Henrik M. Roager, Lea B. S. Hansen, Martin I. Bahl, Henrik L. Frandsen, Vera Carvalho, Rikke J. Gøbel, Marlene D. Dalgaard, Damian R. Plichta, Morten H. Sparholt, Henrik Vestergaard, Torben Hansen, Thomas Sicheritz-Pontén, H. Bjørn Nielsen, Oluf Pedersen, Lotte Lauritzen, Mette Kristensen, Ramneek Gupta, Tine R. Licht. Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut. Nature Microbiology, 2016; 1: 16093 DOI: 10.1038/nmicrobiol.2016.93

August 2016

IHCAN AUGUST references


SACN vitamin D and health report, from

Public Health England

First published: 21 July 2016

Part of: SACN: reports and position statements and Obesity and healthy eating The Scientific Advisory Committee on Nutrition (SACN) recommendations on vitamin D:

US statistics:

Nahin RL, Barnes PM, Stussman BJ. Expenditures on complementary health approaches: United States, 2012. (433KB PDF) National Health Statistics Reports. Hyattsville, MD: National Center for Health Statistics. 2016.

ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies

Liana C. Del Gobbo et al. JAMA Intern Med. Published online June 27, 2016. doi:10.1001/jamainternmed.2016.2925


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Further reading suggested by Dr Christen Rune Stensvold, PhD (

Pepper, J., & Rosenfeld, S. (2012). The emerging medical ecology of the human gut microbiome Trends in Ecology & Evolution, 27 (7), 381-384 DOI: 10.1016/j.tree.2012.03.002

Dethlefsen, L., & Relman, D. (2010). Colloquium Paper: Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation Proceedings of the National Academy of Sciences, 108 (Supplement_1), 4554-4561 DOI: 10.1073/pnas.1000087107

Stensvold, C., Christiansen, D., Olsen, K., & Nielsen, H. (2011). Blastocystis sp. Subtype 4 is Common in Danish Blastocystis-Positive Patients Presenting with Acute Diarrhea American Journal of Tropical Medicine and Hygiene, 84 (6), 883-885 DOI: 10.4269/ajtmh.2011.11-0005

Domínguez-Márquez, M., Guna, R., Muñoz, C., Gómez-Muñoz, M., & Borrás, R. (2009). High prevalence of subtype 4 among isolates of Blastocystis hominis from symptomatic patients of a health district of Valencia (Spain) Parasitology Research, 105 (4), 949-955 DOI: 10.1007/s00436-009-1485-y

Stensvold, C., (2012). Thinking Blastocystis Out Of The Box. Trends in Parasitology DOI: 10.1016/

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11. Herter-Aeberli I, et al. Iodine Supplementation Decreases Hypercholesterolemia in Iodine-Deficient, Overweight Women: A Randomized Controlled Trial. J Nutr. 2015 Sep;145(9):2067-75.
12. Farhangi MA, Keshavarz SA, Eshraghian M, Ostadrahimi A, Saboor-Yaraghi AA. The effect of vitamin A supplementation on thyroid function in premenopausal women. J Am Coll Nutr. 2012 Aug;31(4):268-74.
13. Duntas LH, Papanastasiou L, Mantzou E, Koutras DA. Incidence of sideropenia and effects of iron repletion treatment in women with subclinical hypothyroidism. Exp Clin Endocrinol Diabetes. 1999;107(6):356-60.
14. Kandhro GA, Kazi TG, Afridi HI, Kazi N, Baig JA, Arain MB, Sirajuddin, Shah AQ, Sarfraz RA, Jamali MK, Syed N. Effect of zinc supplementation on the zinc level in serum and urine and their relation to thyroid hormone profile in male and female goitrous patients. Clin Nutr. 2009 Apr;28(2):162-8.
15. Toulis KA, Anastasilakis AD, Tzellos TG, Goulis DG, Kouvelas D. Selenium supplementation in the treatment of Hashimoto’s thyroiditis: a systematic review and a meta-analysis. Thyroid. 2010 Oct;20(10):1163-73.
16. Palinkas LA, Reedy KR, Smith M, Anghel M, Steel GD, Reeves D, Shurtleff D, Case HS, Van Do N, Reed HL. Psychoneuroendocrine effects of combined thyroxine and triiodothyronine versus tyrosine during prolonged Antarctic residence. Int J Circumpolar Health. 2007 Dec;66(5):401-17.
17. Felker P, Bunch R, Leung AM. Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism. Nutr Rev. 2016 Apr;74(4):248-58.
18. Sathyapalan T, Manuchehri AM, Thatcher NJ, Rigby AS, Chapman T, Kilpatrick ES, Atkin SL. The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: a randomized, double-blind, crossover study. J Clin Endocrinol Metab. 2011 May;96(5):1442-9.
19. Messina M, Redmond G. Effects of soy protein and soybean isoflavones on thyroid function in healthy adults and hypothyroid patients: a review of the relevant literature. Thyroid. 2006 Mar;16(3):249-58.
20. Peckham S, Lowery D, Spencer S. Are fluoride levels in drinking water associated with hypothyroidism prevalence in England? A large observational study of GP practice data and fluoride levels in drinking water. J Epidemiol Community Health. 2015 Jul;69(7):619-24.
21. Chandra AK, Goswami H, Sengupta P. Dietary calcium induced cytological and biochemical changes in thyroid. Environ Toxicol Pharmacol. 2012 Sep;34(2):454-65.
22. Wang N, Zhou Y, Fu C, Wang H, Huang P, Wang B, Su M, Jiang F, Fang H, Zhao Q, Chen Y, Jiang Q. Influence of Bisphenol A on Thyroid Volume and Structure Independent of Iodine in School Children. PLoS One. 2015 Oct 23;10(10):e0141248.
23. Pelletier C, Doucet E, Imbeault P, Tremblay A. Associations between weight loss-induced changes in plasma organochlorine concentrations, serum T(3) concentration, and resting metabolic rate. Toxicol Sci. 2002 May;67(1):46-51.
24. Di Matola T, Zeppa P, Gasperi M, Vitale M. Thyroid dysfunction following a kelp-containing marketed diet. BMJ Case Rep. 2014 Oct 29;2014.
25. Sategna-Guidetti C, et al. Prevalence of thyroid disorders in untreated adult celiac disease patients and effect of gluten withdrawal: an Italian multicenter study. Am J Gastroenterol. 2001 Mar;96(3):751-7.

PANEL: Antje Brüser, Angela Schulz, Sven Rothemund, Albert Ricken, Davide Calebiro, Gunnar Kleinau, Torsten Schöneberg. The Activation Mechanism of Glycoprotein Hormone Receptors with Implications in the Cause and Therapy of Endocrine Diseases. Journal of Biological Chemistry, 2016; 291 (2): 508 DOI: 10.1074/jbc.M115.701102

Miguel’s key papers and suggestions for further reading

Bhullar, K. S. & Rupasinghe, H. P. (2013) Polyphenols: multipotent therapeutic agents in neurodegenerative diseases. Oxid Med Cell Longev, 2013pp. 891748.

Cascalheira, J. F., Goncalves, M., Barroso, M., Castro, R., Palmeira, M., Serpa, A., Dias-Cabral, A. C., Domingues, F. C. & Almeida, S. (2015) Association of the transcobalamin II gene 776C –> G polymorphism with Alzheimer’s type dementia: dependence on the 5, 10-methylenetetrahydrofolate reductase 1298A –> C polymorphism genotype. Ann Clin Biochem, 52(Pt 4) pp. 448-55.

Fowler, A. K., Hewetson, A., Agrawal, R. G., Dagda, M., Dagda, R., Moaddel, R., Balbo, S., Sanghvi, M., Chen, Y., Hogue, R. J., Bergeson, S. E., Henderson, G. I. & Kruman, Ii (2012) Alcohol-induced one-carbon metabolism impairment promotes dysfunction of DNA base excision repair in adult brain. J Biol Chem, 287(52) pp. 43533-42.

Iriti, M. & Varoni, E. M. (2015) Melatonin in Mediterranean diet, a new perspective. J Sci Food Agric, 95(12) pp. 2355-9.

Lopes Da Silva, S., Vellas, B., Elemans, S., Luchsinger, J., Kamphuis, P., Yaffe, K., Sijben, J., Groenendijk, M. & Stijnen, T. (2014) Plasma nutrient status of patients with Alzheimer’s disease: Systematic review and meta-analysis. Alzheimers Dement, 10(4) pp. 485-502.

Pallauf, K., Giller, K., Huebbe, P. & Rimbach, G. (2013) Nutrition and healthy ageing: calorie restriction or polyphenol-rich “MediterrAsian” diet? Oxid Med Cell Longev, 2013pp. 707421.

Pedret, A., Valls, R. M., Fernandez-Castillejo, S., Catalan, U., Romeu, M., Giralt, M., Lamuela-Raventos, R. M., Medina-Remon, A., Arija, V., Aranda, N., Espinel, A., Delgado, M. A. & Sola, R. (2012) Polyphenol-rich foods exhibit DNA antioxidative properties and protect the glutathione system in healthy subjects. Mol Nutr Food Res, 56(7) pp. 1025-33.

Rai, V. (2016) Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism and Alzheimer Disease Risk: a Meta-Analysis. Mol Neurobiol, pp.

Scoditti, E., Capurso, C., Capurso, A. & Massaro, M. (2014) Vascular effects of the Mediterranean diet-part II: role of omega-3 fatty acids and olive oil polyphenols. Vascul Pharmacol, 63(3) pp. 127-34.
Shen, L. & Ji, H. F. (2015) Associations between Homocysteine, Folic Acid, Vitamin B12 and Alzheimer’s Disease: Insights from Meta-Analyses. J Alzheimers Dis, 46(3) pp. 777-90.

Toledo, E., Salas-Salvado, J., Donat-Vargas, C., Buil-Cosiales, P., Estruch, R., Ros, E., Corella, D., Fito, M., Hu, F. B., Aros, F., Gomez-Gracia, E., Romaguera, D., Ortega-Calvo, M., Serra-Majem, L., Pinto, X., Schroder, H., Basora, J., Sorli, J. V., Bullo, M., Serra-Mir, M. & Martinez-Gonzalez, M. A. (2015) Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial. JAMA Intern Med, 175(11) pp. 1752-60.

Tuttolomondo, A., Casuccio, A., Butta, C., Pecoraro, R., Di Raimondo, D., Della Corte, V., Arnao, V., Clemente, G., Maida, C., Simonetta, I., Miceli, G., Lucifora, B., Cirrincione, A., Di Bona, D., Corpora, F., Maugeri, R., Iacopino, D. G. & Pinto, A. (2015) Mediterranean Diet in patients with acute ischemic stroke: Relationships between Mediterranean Diet score, diagnostic subtype, and stroke severity index. Atherosclerosis, 243(1) pp. 260-7.


Daniel Brugger, Wilhelm M. Windisch. Subclinical zinc deficiency impairs pancreatic digestive enzyme activity and digestive capacity of weaned piglets. British Journal of Nutrition, 2016; 1 (doi: 10.1017/S0007114516002105).

Sci Rep. 2016 Jun 3;6:27010. doi: 10.1038/srep27010.
Paternal under-nutrition programs metabolic syndrome in offspring which can be reversed by antioxidant/vitamin food fortification in fathers.
McPherson NO1,2, Fullston T1, Kang WX1, Sandeman LY1, Corbett MA3, Owens JA1, Lane M1,4.

J Med Food. 2016 May 20. [Epub ahead of print] doi: 10.1089/jmf.2016.0030.
Inhibition of TNF-α, IL-1α, and IL-1β by Pretreatment of Human Monocyte-Derived Macrophages with Menaquinone-7 and Cell Activation with TLR Agonists In Vitro.
Pan MH, Maresz K5, Lee PS4, Wu JC4, Ho CT6, Popko J7,8, Mehta DS9, Stohs SJ10, Badmaev V.

Ramon Estruch, Miguel Angel Martínez-González, Dolores Corella, Jordi Salas-Salvadó, Montserrat Fitó, Gemma Chiva-Blanch, Miquel Fiol, Enrique Gómez-Gracia, Fernando Arós, José Lapetra, Lluis Serra-Majem, Xavier Pintó, Pilar Buil-Cosiales, José V Sorlí, Miguel A Muñoz, Josep Basora-Gallisá, Rosa María Lamuela-Raventós, Mercè Serra-Mir, Emilio Ros. Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial. The Lancet Diabetes & Endocrinology, 2016; DOI: 10.1016/S2213-8587(16)30085-7
Moran Yassour et al. Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability. Science Translational Medicine, 2016 DOI: 10.1126/scitranslmed.aad0917 .
Franziska Faber, Lisa Tran, Mariana X. Byndloss, Christopher A. Lopez, Eric M. Velazquez, Tobias Kerrinnes, Sean-Paul Nuccio, Tamding Wangdi, Oliver Fiehn, Renée M. Tsolis, Andreas J. Bäumler. Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion. Nature, 2016; DOI: 10.1038/nature18597 .
Catherine R. Marinac, Sandahl H. Nelson, Caitlin I. Breen, Sheri J. Hartman, Loki Natarajan, John P. Pierce, Shirley W. Flatt, Dorothy D. Sears, Ruth E. Patterson. Prolonged Nightly Fasting and Breast Cancer Prognosis. JAMA Oncology, 2016; DOI: 10.1001/jamaoncol.2016.0164.
Sara Vieira-Silva, Gwen Falony, Youssef Darzi, Gipsi Lima-Mendez, Roberto Garcia Yunta, Shujiro Okuda, Doris Vandeputte, Mireia Valles-Colomer, Falk Hildebrand, Samuel Chaffron, Jeroen Raes. Species–function relationships shape ecological properties of the human gut microbiome. Nature Microbiology, 2016; 16088 DOI: 10.1038/nmicrobiol.2016.88.
Lakshmi Krishnamoorthy, Joseph A Cotruvo, Jefferson Chan, Harini Kaluarachchi, Abigael Muchenditsi, Venkata S Pendyala, Shang Jia, Allegra T Aron, Cheri M Ackerman, Mark N Vander Wal, Timothy Guan, Lukas P Smaga, Samouil L Farhi, Elizabeth J New, Svetlana Lutsenko, Christopher J Chang. Copper regulates cyclic-AMP-dependent lipolysis. Nature Chemical Biology, 2016; DOI: 10.1038/nchembio.2098
Dale E. Bredesen, Edwin C. Amos3, Jonathan Canick4, Mary Ackerley5, Cyrus Raji6, Milan Fiala7, and Jamila Ahdidan, Aging 2016, 8 (6): online at

Bredesen DE. Reversal of cognitive decline: A novel therapeutic program. Aging 2014; 6:707-17. Doi: 10.18632/aging.100690.

June 2016

IHCAN June 2016 references

Emily G Severance, Kristin L Gressitt, Catherine R Stallings, Emily Katsafanas, Lucy A Schweinfurth, Christina L Savage, Maria B Adamos, Kevin M Sweeney, Andrea E Origoni, Sunil Khushalani, F Markus Leweke, Faith B Dickerson, Robert H Yolken. Candida albicans exposures, sex specificity and cognitive deficits in schizophrenia and bipolar disorder. npj Schizophrenia, 2016; 2: 16018 DOI: 10.1038/npjschz.2016.18
Martin A Makary, Michael Daniel. Medical error—the third leading cause of death in the US. BMJ, 2016; i2139 DOI: 10.1136/bmj.i2139
Jacquelaine Bartlett, Irene M. Predazzi, Scott M. Williams, William S. Bush, Yeunjung Kim, Stephen Havas, Peter P. Toth, Sergio Fazio, Michael Miller. Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor? Circulation: Cardiovascular Quality and Outcomes, 2016; CIRCOUTCOMES.115.002436 DOI: 10.1161/CIRCOUTCOMES.115.002436
Nutrition. 2016 Feb 13. pii: S0899-9007(16)00075-7. doi: 10.1016/j.nut.2016.01.021. [Epub ahead of print]Is it gluten-free? Relationship between self-reported gluten-free diet adherence and knowledge of gluten content of foods.
Silvester JA1, Weiten D2, Graff LA3, Walker JR3, Duerksen DR4
(Nutrition 2016, doi: 10.1016/j.nut.2016.01.021.)

Katharine A. Rimes, Joanna Ashcroft, Lauren Bryan, Trudie Chalder. Emotional Suppression in Chronic Fatigue Syndrome: Experimental Study.. Health Psychology, 2016; DOI: 10.1037/hea0000341
Toni Ali-Sisto, Tommi Tolmunen, Elena Toffol, Heimo Viinamäki, Pekka Mäntyselkä, Minna Valkonen-Korhonen, Kirsi Honkalampi, Anu Ruusunen, Vidya Velagapudi, Soili M. Lehto. Purine metabolism is dysregulated in patients with major depressive disorder. Psychoneuroendocrinology, 2016; 70: 25 DOI: 10.1016/j.psyneuen.2016.04.017
Hilary P. Browne, Samuel C. Forster, Blessing O. Anonye, Nitin Kumar, B. Anne Neville, Mark D. Stares, David Goulding, Trevor D. Lawley. Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation. Nature, 2016; DOI: 10.1038/nature17645


1. Ginsburg GS, Willard HF. Genomic and personalized medicine: foundations and applications. Transl Res. 2009 Dec;154(6):277-87.
2. Minich DM, Bland JS. Personalized lifestyle medicine: relevance for nutrition and lifestyle recommendations. ScientificWorldJournal. 2013 Jun 26;2013:129841.
3. Fenech M, El-Sohemy A, Cahill L, et al. Nutrigenetics and nutrigenomics: viewpoints on the current status and applications in nutrition research and practice. J Nutrigenet Nutrigenomics. 2011;4(2):69-89.
4. Sykiotis GP, Kalliolias GD, Papavassiliou AG. Pharmacogenetic principles in the Hippocratic writings. J Clin Pharmacol. 2005 Nov;45(11):1218-20.
5. Jaiswal YS, Williams LL, A glimpse of Ayurveda e The forgotten history and principles of Indian traditional medicine, Journal of Traditional and Complementary Medicine (2016),
6. Gupta PD. Pharmacogenetics, pharmacogenomics and ayurgenomics for personalized medicine: a paradigm shift. Indian J Pharm Sci. 2015 Mar-Apr;77(2):135-41.
7. Prasher B, Gibson G, Mukerji M. Genomic insights into ayurvedic and western approaches to personalized medicine. J Genet. 2016 Mar;95(1):209-28.
8. Rotti H, Mallya S, Kabekkodu SP, et al. DNA methylation analysis of phenotype specific stratified Indian population. J Transl Med. 2015 May 8;13:151.
9. Govindaraj P, Nizamuddin S, Sharath A, et al. Genome-wide analysis correlates Ayurveda Prakriti. Sci Rep. 2015 Oct 29;5:15786.
10. Prasher B, Negi S, Aggarwal S, et al. Whole genome expression and biochemical correlates of extreme constitutional types defined in Ayurveda. J Transl Med. 2008 Sep 9;6:48.
11. Mahalle, N. P., Kulkarni, M. V., Pendse, N. M. & Naik, S. S. Association of constitutional type of Ayurveda with cardiovascular risk factors, inflammatory markers and insulin resistance. J. Ayurveda Integr. Med. 3, 150–157 (2012).
12. DuBroff R, Lad V, Murray-Krezan C. A Prospective Trial of Ayurveda for Coronary Heart Disease: A Pilot Study. Altern Ther Health Med. 2015 Sep-Oct;21(5):52-62.
13. Rasmussen LB, Mikkelsen K, Haugen M, et al. Treatment of fibromyalgia at the Maharishi Ayurveda Health Centre in Norway. A six-month follow-up study. Clin Exp Rheumatol. 2009 Sep-Oct;27(5 Suppl 56):S46-50.
14. Patel KB, Patel M, Mehta CS, Gupta S, Kessler CS. Ayurvedic management of ulcerative colitis–a non-randomized observational clinical study. Forsch Komplementmed. 2013;20(2):144-7.
15. Banerjee S, Debnath P, Debnath PK. Ayurnutrigenomics: Ayurveda-inspired personalized nutrition from inception to evidence. J Tradit Complement Med. 2015 Mar 24;5(4):228-33.

Further reading – Part 1
1. Chow, H. M. & Herrup, K. (2015) Genomic integrity and the ageing brain. Nat Rev Neurosci, 16(11) pp. 672-84.
2. St Laurent, G., 3rd, Hammell, N. & Mccaffrey, T. A. (2010) A LINE-1 component to human aging: do LINE elements exact a longevity cost for evolutionary advantage? Mech Ageing Dev, 131(5) pp. 299-305.
3. Ames, B. N., Atamna, H. & Killilea, D. W. (2005) Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging. Mol Aspects Med, 26(4-5) pp. 363-78.
4. Hernandez-Aguilera, A., Rull, A., Rodriguez-Gallego, E., Riera-Borrull, M., Luciano-Mateo, F., Camps, J., Menendez, J. A. & Joven, J. (2013) Mitochondrial dysfunction: a basic mechanism in inflammation-related non-communicable diseases and therapeutic opportunities. Mediators Inflamm, 2013pp. 135698.
5. Meramat, A., Rajab, N. F., Shahar, S. & Sharif, R. (2015) Cognitive impairment, genomic instability and trace elements. J Nutr Health Aging, 19(1) pp. 48-57.


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58. Hagele TJ, Mazerik JN, Gregory A, Kaufman B, Magalang U, et al. (2007) Mercury activates vascular endothelial cell phospholipase D through thiols and oxidative stress.Int J Toxicol 26: 57-69.

59. Peltz A, Sherwani SI, Kotha SR, Mazerik JN, O’Connor Butler ES, et al. (2009) Calcium and calmodulin regulate mercury-induced phospholipase D activation in vascular endothelial cells.Int J Toxicol 28: 190-206.

60. Wiggers GA, Peçanha FM, Briones AM, Pérez-Girón JV, Miguel M, et al. (2008) Low mercury concentrations cause oxidative stress and endothelial dysfunction in conductance and resistance arteries.Am J Physiol Heart CircPhysiol 295: H1033-1033H1043.

61. Al-Saleh I, Shinwari N, Mashhour A, Mohamed Gel-D, Ghosh MA, et al. (2006) Cadmium and mercury levels in Saudi women and its possible relationship with hypertension.Biol Trace Elem Res 112: 13-29.

62. Fillion M, Mergler D, Sousa Passos CJ, Larribe F, Lemire M, et al. (2006) A preliminary study of mercury exposure and blood pressure in the Brazilian Amazon.Environ Health 5: 29.

63. Bautista LE, Stein JH, Morgan BJ, Stanton N, Young T, et al. (2009) Association of blood and hair mercury with blood pressure and vascular reactivity.WMJ 108: 250-252.

64. Valera B, Dewailly E, Poirier P (2009) Environmental mercury exposure and blood pressure among Nunavik Inuit adults.Hypertension 54: 981-986.

65. Yorifuji T, Tsuda T, Kashima S, Takao S, Harada M (2010) Long-term exposure to methylmercury and its effects on hypertension in Minamata.Environ Res 110: 40-46.

66. Vupputuri S, Longnecker MP, Daniels JL, Guo X, Sandler DP (2005) Blood mercury level and blood pressure among US women: results from the National Health and Nutrition Examination Survey 1999-2000.Environ Res 97: 195-200.

67. Moszczyski P (2006) [Mercury and the risk of coronary heart disease].PrzeglLek 63 Suppl 7: 84-87.

68. Virtanen JK, Rissanen TH, Voutilainen S, Tuomainen TP (2007) Mercury as a risk factor for cardiovascular diseases.J NutrBiochem 18: 75-85.

69. Wennberg M, Strömberg U, Bergdahl IA, Jansson JH, Kauhanen J, et al. (2012) Myocardial infarction in relation to mercury and fatty acids from fish: a risk-benefit analysis based on pooled Finnish and Swedish data in men.Am J ClinNutr 96: 706-713.

70. Virtanen JK, Laukkanen JA, Mursu J, Voutilainen S, Tuomainen TP (2012) Serum long-chain n-3 polyunsaturated fatty acids, mercury, and risk of sudden cardiac death in men: a prospective population-based study.PLoS One 7: e41046.

71. Mozaffarian D, Shi P, Morris JS, Spiegelman D, Grandjean P, et al. (2011) Mercury exposure and risk of cardiovascular disease in two U.S. cohorts. N Engl J Med 364: 1116-1125.

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76. Lim KM, Kim S, Kim K, Jang WH, Bae ON, et al. (2010) Low- level mercury can enhance procoagulant activity of erythrocytes: a new contributing factor for mercury-related thrombotic disease. Environ Health Perspect. 118:928-935.

77. Pedersen EB, Jørgensen ME, Pedersen MB, Siggaard C, Sørensen TB, et al. (2005) Relationship between mercury in blood and 24-h ambulatory blood pressure in Greenlanders and Danes.Am J Hypertens 18: 612-618.

78. García Gómez M, Boffetta P, Caballero Klink JD, Español S, Gómez Quintana J (2007) [Cardiovascular mortality in mercury miners].Med Clin (Barc) 128: 766-771.

79. Choi AL, Weihe P, Budtz-Jørgensen E, Jørgensen PJ, Salonen JT, et al. (2009) Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men.Environ Health Perspect 117: 367-372.

80. Valera B, Dewailly E, Poirier P (2008) Cardiac autonomic activity and blood pressure among Nunavik Inuit adults exposed to environmental mercury: a cross-sectional study.Environ Health 7: 29.

O. van de Rest, Y. Wang, L. L. Barnes, C. Tangney, D. A. Bennett, M. C. Morris. APOE 4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline. Neurology, 2016; DOI: 10.1212/WNL.0000000000002719
Jerome Sarris, Jenifer Murphy, David Mischoulon, George I. Papakostas, Maurizio Fava, Michael Berk, Chee H. Ng. Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses. American Journal of Psychiatry, 2016; appi.ajp.2016.1 DOI: 10.1176/appi.ajp.2016.15091228

Adrian Raine, Rose A. Cheney, Ringo Ho, Jill Portnoy, Jianghong Liu, Liana Soyfer, Joseph Hibbeln, Therese S. Richmond. Nutritional supplementation to reduce child aggression: a randomized, stratified, single-blind, factorial trial. Journal of Child Psychology and Psychiatry, 2016; DOI: 10.1111/jcpp.12565
Adrian Raine, Jill Portnoy, Jianghong Liu, Tashneem Mahoomed, Joseph R. Hibbeln. Reduction in behavior problems with omega-3 supplementation in children aged 8-16 years: a randomized, double-blind, placebo-controlled, stratified, parallel-group trial. Journal of Child Psychology and Psychiatry, 2015; 56 (5): 509 DOI: 10.1111/jcpp.12314

Qingying Meng, Zhe Ying, Emily Noble, Yuqi Zhao, Rahul Agrawal, Andrew Mikhail, Yumei Zhuang, Ethika Tyagi, Qing Zhang, Jae-Hyung Lee, Marco Morselli, Luz Orozco, Weilong Guo, Tina M. Kilts, Jun Zhu, Bin Zhang, Matteo Pellegrini, Xinshu Xiao, Marian F. Young, Fernando Gomez-Pinilla, Xia Yang. Systems Nutrigenomics Reveals Brain Gene Networks Linking Metabolic and Brain Disorders. EBioMedicine, 2016; DOI: 10.1016/j.ebiom.2016.04.008
Nathan F. Johnson, Brian T. Gold, Alison L. Bailey, Jody L. Clasey, Jonathan G. Hakun, Matthew White, Doug E. Long, David K. Powell. Cardiorespiratory fitness modifies the relationship between myocardial function and cerebral blood flow in older adults. NeuroImage, 2016; 131: 126 DOI: 10.1016/j.neuroimage.2015.05.063
Vittori Gouveia Luciana de Almeida, Cardoso Carolina Alves, de Oliveira Glaucia Maria Moraes, Rosa Glorimar, and Moreira Annie Seixas Bello. Journal of Medicinal Food. April 2016, 19(4): 337-345. doi:10.1089/jmf.2015.0075. Published in Volume: 19 Issue 4: April 13, 2016

David K. Cole, Anna M. Bulek, Garry Dolton, Andrea J. Schauenberg, Barbara Szomolay, William Rittase, Andrew Trimby, Prithiviraj Jothikumar, Anna Fuller, Ania Skowera, Jamie Rossjohn, Cheng Zhu, John J. Miles, Mark Peakman, Linda Wooldridge, Pierre J. Rizkallah, Andrew K. Sewell. Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. Journal of Clinical Investigation, 2016; DOI: 10.1172/JCI85679.
Robert I. Richards, Sarah A. Robertson, Louise V. O’Keefe, Dani Fornarino, Andrew Scott, Michael Lardelli, Bernhard T. Baune. The Enemy within: Innate Surveillance-Mediated Cell Death, the Common Mechanism of Neurodegenerative Disease. Frontiers in Neuroscience, 2016; 10 DOI: 10.3389/fnins.2016.00193
G. Hagen, T. Wisløff, I. S. Kristiansen. The predicted lifetime costs and health consequences of calcium and vitamin D supplementation for fracture prevention—the impact of cardiovascular effects. Osteoporosis International, 2016; 27 (6): 2089 DOI: 10.1007/s00198-016-3495-9
Mingzhan Xue, Martin O Weickert, Sheharyar Qureshi, Ngianga-Bakwin Kandala, Attia Anwar, Molly Waldron, Alaa Shafie, David Messenger, Mark Fowler, Gail Jenkins, Naila Rabbani, Paul J. Thornalley. Improved glycemic control and vascular function in overweight and obese subjects by glyoxalase 1 inducer formulation. Diabetes, 2016; db160153 DOI: 10.2337/db16-0153
Julia K. Goodrich, Emily R. Davenport, Michelle Beaumont, Matthew A. Jackson, Rob Knight, Carole Ober, Tim D. Spector, Jordana T. Bell, Andrew G. Clark, Ruth E. Ley. Genetic Determinants of the Gut Microbiome in UK Twins. Cell Host & Microbe, 2016; 19 (5): 731 DOI: 10.1016/j.chom.2016.04.017

May 2016


J. Paccou et al. Ischemic heart disease is associated with lower cortical volumetric bone mineral density of distal radius. Osteoporosis International
July 2015, Volume 26, Issue 7, pp 1893-1901.

Elizabeth M. Curtis, Robert van der Velde, Rebecca J. Moon, Joop P.W. van den Bergh, Piet Geusens, Frank de Vries, Tjeerd P. van Staa, Cyrus Cooper, Nicholas C. Harvey. Epidemiology of fractures in the United Kingdom 1988–2012: Variation with age, sex, geography, ethnicity and socioeconomic status. Bone, 2016; 87: 19 DOI: 10.1016/j.bone.2016.03.006.

Stenson WF, Newberry R, Lorenz R, Baldus C, Civitelli R. Increased prevalence of celiac disease and need for routine screening among patients with osteoporosis. Archives of Internal Medicine; vol. 165, pp. 393-399, Feb. 28, 2005. doi: 10.1001/archinte.165.4.393.

Osteoporosis Associated with Neutralizing Autoantibodies against Osteoprotegerin
Philip L. Riches, M.R.C.P., Euan McRorie, F.R.C.P., William D. Fraser, Ph.D., F.R.C.Path., Catherine Determann, B.Med.Sci., Rob van’t Hof, Ph.D., and Stuart H. Ralston, M.D.
N Engl J Med 2009; 361:1459-1465 October 8, 2009 DOI: 10.1056/NEJMoa0810925

Bone Metabolism in Celiac Disease
Chiara Zanchi, MD Grazia Di Leo, MD Luca Ronfani, MD, Stefano Martelossi, MD, Tarcisio Not, MD, Alessandro Ventura, MD Journal of Pediatrics, August 2008, Volume 153, Issue 2, Pages 262–265, DOI:
Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity.
Carroccio A1, Mansueto P, Iacono G, Soresi M, D’Alcamo A, Cavataio F, Brusca I, Florena AM, Ambrosiano G, Seidita A, Pirrone G, Rini GB. Am J Gastroenterol. 2012 Dec;107(12):1898-906; quiz 1907. doi: 10.1038/ajg.2012.236. Epub 2012 Jul 24.

Fructan content of commonly consumed wheat, rye and gluten-free breads.
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Int J Food Sci Nutr. 2011 Aug;62(5):498-503. doi: 10.3109/09637486.2011.553588. Epub 2011 Mar 23.

Kohn et al. A cardiovascular phenotype in warfarin-resistant Vkorc1 mutant rats☆. Artery Research, 2008; 2 (4): 138 DOI: 10.1016/j.artres.2008.09.002

Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
Knapen MH, Braam LA, Drummen NE, Bekers O, Hoeks AP, Vermeer C1. Thromb Haemost. 2015 May;113(5):1135-44. doi: 10.1160/TH14-08-0675. Epub 2015 Feb 19.

Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. M. H. J. Knapen, N. E. Drummen, E. Smit, C. Vermeer, E. Theuwissen . Osteoporosis International September 2013, Volume 24, Issue 9, pp 2499-2507. First online: 23 March 2013

April 2016

Bruno R da Costa, Stephan Reichenbach, Noah Keller, Linda Nartey, Simon Wandel, Peter Jüni, Sven Trelle. Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. The Lancet, 2016; DOI: 10.1016/S0140-6736(16)30002-2

ALZHEIMER’S 1,2. Prince MA, Emiliano; Guerchet, Maëlenn; Prina, Matthew. 2014; World Alzheimer Report 2014 United Kingdom: Alzheimer’s Disease International.

3. James BD, Leurgans SE, Hebert LE, Scherr PA, Yaffe K and Bennett DA. Contribution of Alzheimer disease to mortality in the United States. Neurology. 2014; 82:1045-1050. 4. 5. Shriver M. A Woman’s Nation Takes on Alzheimer’s. 2010; New York, USA: Alzheimer’s Association. 6. 2014 Alzheimer’s Disease Facts and Figures. Special Report on Women and Alzheimer’s Disease. USA: Alzheimer’s Association, 2014; pp. 1-80. 7. 8. Bredesen D. Reversal of cognitive decline: A novel therapeutic program. 2014; Los Angeles: Impact Journals. 9. 10. Bredesen D. Reversal of cognitive decline: A novel therapeutic program. 2014; Los Angeles. Impact Journals.

ME/CFS * #MEAction petition * The PACE Lancet paper * Open letter to The Lancet from 42 scientists and doctors * Dr David Tuller’s article on the PACE trial


1. Johannes CB, Le TK, Zhou XL, Johnston JA, Dworkin RH. The prevalence of chronic pain in United States adults results of an internet-based survey. J Pain. 2010;11:1230–1239. 2. Kroenke K, Krebs EE, Bair MJ. Pharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviews. Gen Hosp Psychiatry. 2009;31:206–219. 3. Katz WA, Barkin RL. Dilemmas in chronic/persistent pain management. Am J Ther. 2008 May-Jun;15(3):256-64. 4. Mandiakis and Gray, 2000 N. Mandiakis and A. Gray, The economic burden of low back pain in the United Kingdom, Pain 84 (1) (2000), pp. 95-103. 5. Coxib and Traditional NSAID Trialists’ (CNT) Collaboration. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet. 2013;382:769–779. 6. da Costa BR, Reichenbach S, Keller N, et al. Eff ectiveness of non-steroidal anti-infl ammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. Lancet 2016; published online March 17. 7. Moore N, et al. Does paracetamol still have a future in osteoarthritis? Lancet 2016; published online March 17. 8. Staud R. Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions. Expert Rev Neurother. 2012 May;12(5):577-85. 9. Staud R. Evidence for shared pain mechanisms in osteoarthritis, low back pain, and fibromyalgia. Curr Rheumatol Rep. 2011 Dec;13(6):513-20. 10. Muley MM, Krustev E, McDougall JJ. Preclinical Assessment of Inflammatory Pain. CNS Neurosci Ther. 2016 Feb;22(2):88-101. 11. Scrivo R, Vasile M, Bartosiewicz I, Valesini G. Inflammation as “common soil” of the multifactorial diseases. Autoimmun Rev. 2011 May;10(7):369-74. 12. Egger G, Dixon J. Obesity and chronic disease: always offender or often just accomplice? Br J Nutr. 2009 Oct;102(8):1238-42. 13. Arseneau L. Integrative and Functional Medicine in Refractive, Chronic, Complex, Pain Syndromes. Natural Medicine Journal, March 2016 Vol. 8 Issue 3. 14. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol. 2009 Jan;41(1):40-59. 15. Hamidpour R, et al. Frankincense ( rǔ xiāng; boswellia species): from the selection of traditional applications to the novel phytotherapy for the prevention and treatment of serious diseases. J Tradit Complement Med. 2013 Oct;3(4):221-6. 16. Calder PC. Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance. Biochim Biophys Acta. 2015 Apr;1851(4):469-84. 17. Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, Buntragulpoontawee M, Lukkanapichonchut P, Chootip C, Saengsuwan J, Tantayakom K, Laongpech S. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014 Mar 20;9:451-8. 18. Ramsden CE, et al. Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. Pain. 2013 Nov;154(11):2441-51. 19. Kaartinen K, Lammi K, Hypen M, Nenonen M, Hanninen O, Rauma AL. Vegan diet alleviates fibromyalgia symptoms. Scand J Rheumatol. 2000;29(5):308-13. 20. Clinton CM, et al. Whole-foods, plant-based diet alleviates the symptoms of osteoarthritis. Arthritis. 2015;2015:708152. 21. Kjeldsen-Kragh J, Haugen M, Borchgrevink CF, Laerum E, Eek M, Mowinkel P, Hovi K, Førre O. Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis. Lancet. 1991 Oct 12;338(8772):899-902. 22. Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett. 2008 Dec;29(6):902-10. 23. Irwin MR, Olmstead R, Carrillo C, Sadeghi N, Breen EC, Witarama T, Yokomizo M, Lavretsky H, Carroll JE, Motivala SJ, Bootzin R, Nicassio P. Cognitive behavioral therapy vs. Tai Chi for late life insomnia and inflammatory risk: a randomized controlled comparative efficacy trial. Sleep. 2014 Sep 1;37(9):1543-52. 24. Cordero MD, Alcocer-Gómez E, de Miguel M, Culic O, Carrión AM, Alvarez-Suarez JM, Bullón P, Battino M, Fernández-Rodríguez A, Sánchez-Alcazar JA. Can coenzyme q10 improve clinical and molecular parameters in fibromyalgia? Antioxid Redox Signal. 2013 Oct 20;19(12):1356-61. 25. Okifuji A, Hare BD. The association between chronic pain and obesity. J Pain Res. 2015 Jul 14;8:399-408. 26. Licciardone JC, Kearns CM, Minotti DE. Outcomes of osteopathic manual treatment for chronic low back pain according to baseline pain severity: results from the OSTEOPATHIC Trial. Man Ther. 2013 Dec;18(6):533-40.

Trovato A, et al. Redox modulation of cellular stress response and lipoxin A4 expression by Coriolus versicolor in rat brain: Relevance to Alzheimer’s disease pathogenesis. Neurotoxicology. 2015 Oct 1. pii: S0161-813X(15)00165-5. doi: 10.1016/j.neuro.2015.09.012. (epub version). Recent Pat Inflamm Allergy Drug Discov. 2012 Jan;6(1):78-87. Efficacy of Yun Zhi (Coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis. Eliza WL1, Fai CK, Chung LP.

ALLERGIES and INTOLERANCES Perkin MR, Logan K, et al. Randomized trial of the early introduction of allergenic foods in breastfed infants. New England Journal of Medicine, 2016 DOI 10.1056/NEJMoa1514210 [Epub ahead of print] Jung-Hwan Kim, Eun-Ji Jeun, Chun-Pyo Hong, Seong-Hoon Kim, Min Seong Jang, Eun-Jung Lee, Sook Jin Moon, Chang Ho Yun, Sin-Hyeog Im, Seok-Geun Jeong, Beom-Young Park, Kyong-Tai Kim, Ju-Young Seoh, Yoon-Keun Kim, Sung-Jong Oh, Jun-Sang Ham, Bo-Gie Yang, Myoung Ho Jang. Extracellular vesicle–derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression. Journal of Allergy and Clinical Immunology, 2016; 137 (2): 507 DOI: 10.1016/j.jaci.2015.08.016 Roberto Berni Canani, Naseer Sangwan, Andrew T Stefka, Rita Nocerino, Lorella Paparo, Rosita Aitoro, Antonio Calignano, Aly A Khan, Jack A Gilbert, Cathryn R Nagler. Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants. The ISME Journal, 2015; DOI: 10.1038/ismej.2015.151

Matthieu Deschamps, Guillaume Laval, Maud Fagny, Yuval Itan, Laurent Abel, Jean-Laurent Casanova, Etienne Patin, Lluis Quintana-Murci. Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes. The American Journal of Human Genetics, 2016; 98 (1): 5 DOI: 10.1016/j.ajhg.2015.11.014 Michael Dannemann, Aida M. Andrés, Janet Kelso. Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors. The American Journal of Human Genetics, 2016; 98 (1): 22 DOI: 10.1016/j.ajhg.2015.11.015 Tabea Brick, Yvonne Schober, Christian Böcking, Juha Pekkanen, Jon Genuneit, Georg Loss, Jean-Charles Dalphin, Josef Riedler, Roger Lauener, Wolfgang Andreas Nockher, Harald Renz, Outi Vaarala, Charlotte Braun-Fahrländer, Erika von Mutius, Markus Johannes Ege, Petra Ina Pfefferle. ω-3 fatty acids contribute to the asthma-protective effect of unprocessed cow’s milk. Journal of Allergy and Clinical Immunology, 2016; DOI: 10.1016/j.jaci.2015.10.042 RESEARCH YihQ is a sulfoquinovosidase that cleaves sulfoquinovosyl diacylglyceride sulfolipids Gaetano Speciale, Yi Jin, Gideon J Davies, Spencer J Williams & Ethan D Goddard-Borger Nature Chemical Biology 2016, 12, 215–217. doi:10.1038/nchembio.2023. Witawas Handee, Xiaobo Li, Kevin W. Hall, Xiexiong Deng, Pan Li, Christoph Benning, Barry L. Williams, Min-Hao Kuo. An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast. PLOS Genetics, 2016; 12 (2): e1005878 DOI: 10.1371/journal.pgen.1005878 Loucks, Eric B.; Gilman, Stephen E.; Britton, Willoughby B.; Gutman, Roee; Eaton, Charles B.; Buka, Stephen L. Associations of Mindfulness with Glucose Regulation and Diabetes. American Journal of Health Behavior, February 2016 DOI: 10.5993/AJHB.40.2.11 Samuel E. Marsh, Edsel M. Abud, Anita Lakatos, Alborz Karimzadeh, Stephen T. Yeung, Hayk Davtyan, Gianna M. Fote, Lydia Lau, Jason G. Weinger, Thomas E. Lane, Matthew A. Inlay, Wayne W. Poon, Mathew Blurton-Jones. The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function. Proceedings of the National Academy of Sciences, 2016; 201525466 DOI: 10.1073/pnas.1525466113 Sean M. Grimmond et al. Genomic analyses identify molecular subtypes of pancreatic cancer. Nature, 2016; DOI: 10.1038/nature16965 Influence of Obesity on Breast Density Reduction by Omega-3 Fatty Acids: Evidence from a Randomized Clinical Trial. Sandhu N, Schetter SE, Liao J, Hartman TJ, Richie JP, McGinley J, Thompson HJ, Prokopczyk B, DuBrock C, Signori C, Hamilton C, Calcagnotto A, Trushin N, Aliaga C, Demers LM, El-Bayoumy K, Manni A. Cancer Prev Res (Phila). 2015 Dec 29. [Epub ahead of print] Aubrey J Cunnington, Kathleen Sim, Aniko Deierl, J Simon Kroll, Eimear Brannigan, Jonathan Darby. “Vaginal seeding” of infants born by caesarean section. BMJ, 2016; i227 DOI: 10.1136/bmj.i227 Molly K. Gibson, Bin Wang, Sara Ahmadi, Carey-Ann D. Burnham, Phillip I. Tarr, Barbara B. Warner, Gautam Dantas. Developmental dynamics of the preterm infant gut microbiota and antibiotic resistome. Nature Microbiology, 2016; 16024 DOI: 10.1038/nmicrobiol.2016.24

March 2016

NEWS Jorge Vas, Koldo Santos-Rey, Reyes Navarro-Pablo, Manuela Modesto, Inmaculada Aguilar, M Ángeles Campos, José Francisco Aguilar-Velasco, Milagrosa Romero, Patricia Párraga, Vanesa Hervás, Olalla Santamaría, Carmen Márquez-Zurita, Francisco Rivas-Ruiz. Acupuncture for fibromyalgia in primary care: a randomised controlled trial. Acupuncture in Medicine, 2016; acupmed-2015-010950 DOI: 10.1136/acupmed-2015-010950.
Ferric C. Fang, Anthony Bowen and Arturo Casadevall. NIH Peer Review Percentile Scores are Poorly Predictive of Grant Productivity. eLife, 2016, DOI:

Sung Ryeol Park, Ashootosh Tripathi, Jianfeng Wu, Pamela J. Schultz, Isaiah Yim, Thomas J. McQuade, Fengan Yu, Carl-Johan Arevang, Abraham Y. Mensah, Giselle Tamayo-Castillo, Chuanwu Xi, David H. Sherman. Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway. Nature Communications, 2016; 7: 10710 DOI: 10.1038/ncomms10710. Charbonneau et al. Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition. Cell, 2016 DOI: 10.1016/j.cell.2016.01.024. L. Claxton, M. Taylor, E. Kay. Oral health promotion: the economic benefits to the NHS of increased use of sugarfree gum in the UK. BDJ, 2016; 220 (3): 121 DOI: 10.1038/sj.bdj.2016.94.

“Adding fluoride to water supply may have no benefit, say experts”. Haroon Siddique. The Guardian, Friday 25 December 2015:

M. Schwarzer, K. Makki, G. Storelli, I. Machuca-Gayet, D. Srutkova, P. Hermanova, M. E. Martino, S. Balmand, T. Hudcovic, A. Heddi, J. Rieusset, H. Kozakova, H. Vidal, F. Leulier. Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition. Science, 2016; 351 (6275): 854 DOI: 10.1126/science.aad8588. Associated references: Lactobacillus plantarum promotes Drosophila systemic growth by modulating hormonal signals through TOR-dependent nutrient sensing, Gilles Storelli, Arnaud Defaye, Berra Erkosar, Pascal Hols, Julien Royet, François Leulier, Cell Metabolism (2011) 14(3):403-414; and Pathogen Virulence Impedes Mutualist-Mediated Enhancement of Host Juvenile Growth via Inhibition of Protein Digestion. Berra Erkosar, Gilles Storelli, Mélanie Mitchell, Loan Bozonnet, Noémie Bozonnet, François Leulier. Cell Host and Microbe (2015) 18(4):445-55. Ana Isabel Ribeiro, Elias Teixeira Krainski, Marilia Sá Carvalho, Maria de Fátima de Pina. Where do people live longer and shorter lives? An ecological study of old-age survival across 4404 small areas from 18 European countries. Journal of Epidemiology and Community Health, 2016; jech-2015-206827 DOI: 10.1136/jech-2015-206827 . Cynthia Owsley, Gerald McGwin, Mark E. Clark, Gregory R. Jackson, Michael A. Callahan, Lanning B. Kline, C. Douglas Witherspoon, Christine A. Curcio. Delayed Rod-Mediated Dark Adaptation Is a Functional Biomarker for Incident Early Age-Related Macular Degeneration. Ophthalmology, 2016; 123 (2): 344 DOI: 10.1016/j.ophtha.2015.09.041. Line Pedersen et al. Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution. Cell Metabolism, February 2016 DOI: 10.1016/j.cmet.2016.01.011 Anil K. Singh, Sadiq Umar, Sharayah Riegsecker, Mukesh Chourasia, Salahuddin Ahmed. Regulation of Transforming Growth Factor β-Activated Kinase Activation by Epigallocatechin-3-Gallate in Rheumatoid Arthritis Synovial Fibroblasts: Suppression of K63-Linked Autoubiquitination of Tumor Necrosis Factor Receptor-Associated Factor 6. Arthritis & Rheumatology, 2016; 68 (2): 347 DOI: 10.1002/art.39447

GUT HEALTH and PROBIOTICS Julie Urban, Daniel J. Fergus, Amy M. Savage, Megan Ehlers, Holly L. Menninger, Robert R. Dunn, Julie E. Horvath. The effect of habitual and experimental antiperspirant and deodorant product use on the armpit microbiome. PeerJ, 2016; 4: e1605 DOI: 10.7717/peerj.1605 Shuichi Tonomura, Masafumi Ihara, Tomohiro Kawano, Tomotaka Tanaka, Yoshinori Okuno, Satoshi Saito, Robert P. Friedland, Nagato Kuriyama, Ryota Nomura, Yoshiyuki Watanabe, Kazuhiko Nakano, Kazunori Toyoda, Kazuyuki Nagatsuka. Intracerebral hemorrhage and deep microbleeds associated with cnm-positive Streptococcus mutans; a hospital cohort study. Scientific Reports, 2016; 6: 20074 DOI: 10.1038/srep20074 Hongjie Li, Yanyan Qi, Heinrich Jasper. Preventing Age-Related Decline of Gut Compartmentalization Limits Microbiota Dysbiosis and Extends Lifespan. Cell Host & Microbe, 2016; 19 (2): 240 DOI: 10.1016/j.chom.2016.01.008 Vinegar Treatment Prevents the Development of Murine Experimental Colitis via Inhibition of Inflammation and Apoptosis Fengge Shen†, Jiaxuan Feng§, Xinhui Wang†, Zhimin Qi†, Xiaochen Shi†, Yanan An†, Qiaoli Zhang†, Chao Wang†, Mingyuan Liu†#, Bo Liu*†, and Lu Yu*† J. Agric. Food Chem., 2016, 64 (5), pp 1111–1121, DOI: 10.1021/acs.jafc.5b05415


1. Costenbader KH, et al. Genes, epigenetic regulation and environmental factors: which is the most relevant in developing autoimmune diseases? Autoimmun Rev. 2012 Jun;11(8):604-9. 2. Ashan H et al. Oxygen free radicals and systemic autoimmunity. Clin Exp Immunol. 2003 Mar;131(3):398-404. 3. Kurien BT, Scofield RH. Autoimmunity and oxidatively modified autoantigens. Autoimmun Rev. 2008 Jul;7(7):567-73. 4. Perl A. Oxidative stress in the pathology and treatment of systemic lupus erythematosus. Nat Rev Rheumatol. 2013 Nov;9(11):674-86. 5. Wang G, Pierangeli SS, Papalardo E, Ansari GA, Khan MF. Markers of oxidative and nitrosative stress in systemic lupus erythematosus: correlation with disease activity. Arthritis Rheum. 2010 Jul;62(7):2064-72. 6. Ortona E, Margutti P, Matarrese P, Franconi F, Malorni W. Redox state, cell death and autoimmune diseases: a gender perspective. Autoimmun Rev. 2008 Jul;7(7):579-84. 7. Costenbader KH, Kang JH, Karlson EW. Antioxidant intake and risks of rheumatoid arthritis and systemic lupus erythematosus in women. Am J Epidemiol. 2010;172:205–216. 8. Tam LS, et al. Effects of vitamins C and E on oxidative stress markers and endothelial function in patients with systemic lupus erythematosus: A double-blind, placebo-controlled pilot study. J Rheumatol 2005;32:275–282. 9. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev. 2012 Mar 14;3:CD007176. 10. Harris C, Hansen JM. Oxidative stress, thiols, and redox profiles. Methods Mol Biol. 2012;889:325-46. 11. Perricone C, De Carolis C, Perricone R. Glutathione: a key player in autoimmunity. Autoimmun Rev. 2009 Jul;8(8):697-701. 12. Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr. 2015 Mar;54(2):251-63. 13. Allen J, Bradley RD. Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. J Altern Complement Med. 2011 Sep;17(9):827-33. 14. Lai ZW, Hanczko R, Bonilla E, et al. N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2012 Sep;64(9):2937-46. 15. Lai Z-W, Hanczko R, Bonilla E, et al. N-acetylcysteine reduces disease activity by blocking mTOR in T cells of lupus patients. Arthritis and Rheumatism. 2012;64:2937–2946. 16. Doherty E, Oaks Z, Perl A. Increased mitochondrial electron transport chain activity at complex I is regulated by N-acetylcysteine in lymphocytes of patients with systemic lupus erythematosus. Antioxid Redox Signal. 2014 Jul 1;21(1):56-65. 17. Perl A, Hanczko R, Lai ZW, Oaks Z, Kelly R, Borsuk R, Asara JM, Phillips PE. Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin. Metabolomics. 2015;11(5):1157-1174. 18. Li M, Gao W, Ma J, Zhu Y, Li X. Early-stage lupus nephritis treated with N-acetylcysteine: A report of two cases. Exp Ther Med. 2015 Aug;10(2):689-692. Epub 2015 May 21. 19. Khalili M, Azimi A, Izadi V, et al. Does lipoic acid consumption affect the cytokine profile in multiple sclerosis patients: a double-blind, placebo-controlled, randomized clinical trial. Neuroimmunomodulation. 2014;21(6):291-6. 20. Chandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res. 2012 Nov;26(11):1719-25. 21. Samsami-Kor M, Daryani NE, Asl PR, Hekmatdoost A. Anti-Inflammatory Effects of Resveratrol in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo controlled Pilot Study. Arch Med Res. 2015 May;46(4):280-5.

AGEING Deirdre A. Robertson, Rose Anne Kenny. Negative perceptions of ageing modify the association between frailty and cognitive function in older adults. Personality and Individual Differences, 2015; DOI: 10.1016/j.paid.2015.12.010

NUTRIGENOMICS – ANNE PEMBERTON 1. Klinghardt, D. (2013) kryptopyrroluria (Pyroluria) – Lyme Induced Autism.

2. Banerjee R, Zou CG (January 2005). “Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein”. Archives of Biochemistry and Biophysics 433 (1): 144–56. doi:10.1016/ PMID 15581573.


4. Dahlhoff C, Desmarchelier C, Sailer M, Fürst RW, Haag A, et al. (2013) Hepatic Methionine Homeostasis Is Conserved in C57BL/6N Mice on High-Fat Diet Despite Major Changes in Hepatic One-Carbon Metabolism. PLoS ONE 8(3): e57387. doi: 10.1371/journal.pone.0057387

February 2016

NEWSGenotype, B-vitamin status, and androgens affect space flight–induced ophthalmic changes. January 2016 The FASEB Journal vol. 30 no. 1 141-148. Sara R. Zwart* et al.

doi: 10.1096/fj.15-278457.

NEWS – cancer

Vinay Prasad, Jeanne Lenzer, David H Newman. Why cancer screening has never been shown to “save lives”—and what we can do about it. BMJ, 2016; h6080 DOI: 10.1136/bmj.h6080

Gerd Gigerenzer. Full disclosure about cancer screening. BMJ, 2016; h6967 DOI: 10.1136/bmj.h6967

Substantial contribution of extrinsic risk factors to cancer development

Song Wu, Scott Powers, Wei Zhu & Yusuf A. Hannun.

Nature 529, 43–47, (07 January 2016)


Change the cancer conversation. The ‘war on cancer’ has run off course. Efforts must refocus on the best interests of patients, says Colin Macilwain.

01 April 2015: Nature 520, 7 (02 April 2015), doi:10.1038/520007a.

Lancet Oncology. Volume 16, No. 13, p1324–1334, October 2015

Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial

Dr Christophe Le Tourneau, MD ert al. DOI:

Five Years of Cancer Drug Approvals, Innovation, Efficacy, and Costs

Sham Mailankody, MB BS1; Vinay Prasad, MD, MPH1

JAMA Oncol. 2015;1(4):539-540. doi:10.1001/jamaoncol.2015.0373.


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Nature Communications 2013, 4, 1860, doi:10.1038/ncomms2814. The genomics of selection in dogs and the parallel evolution between dogs and humans. Guo-dong Wang et al.



Fat oxidation

New Zealand Blackcurrant Improves Performance and Fat Oxidation in Cyclists, Willems ME1, Myers SD, Blacker S, Cook MD. European Journal of Applied Physiology, 2015


Evaluation of Beneficial Metabolic Effects of Berries in High-Fat Fed C57BL/6J Mice. Lovisa Heyman,1 Ulrika Axling,1 Narda Blanco,2 Olov Sterner,2 Cecilia Holm,1 and Karin Berger1. Journal of Nutrition and Metabolism Volume 2014 (2014), Article ID 403041, Published 14 January 2014

Postprandial glucose, insulin, and free fatty acid responses to sucrose consumed with blackcurrants and lingonberries in healthy women.Törrönen R1, Kolehmainen M, Sarkkinen E, Mykkänen H, Niskanen L. Am J Clin Nutr. 2012 Sep;96(3):527-33. doi: 10.3945/ajcn.112.042184. Epub 2012 Aug 1.

Anthocyanin increases adiponectin secretion and protects against diabetes-related endothelial dysfunction. Liu Y, Li D, Zhang Y, Sun R, Xia M. Am J Physiol Endocrinol Metab. 2014;306(8):E975-88.

Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes. Tsuda T, Ueno Y, Aoki H et al. Biochem Biophys Res Commun. 2004;316(1):149-57.

High Fat Meal Increase of IL-17 is Prevented by Ingestion of Fruit Juice Drink in Healthy Overweight Subjects. Peluso, IlariaRaguzzini, Anna Villano, Debora V Cesqui, EleonoraToti, ElisabettaCatasta, GiovinaSerafini, Mauro. CURRENT PHARMACEUTICAL DESIGN 2012, 18:

Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expres-sion in diabetic mice. Sasaki R, Nishimura N, Hoshino H, Isa Y, Kadowaki M, Ichi T, Tanaka A, Nishiumi S, Fukuda I, Ashida H, Horio F, Tsuda, T. (2007). Biochem Pharmacol. 2007; 74(11):1619-27

Polyphenol-rich blackcurrant extract prevents inflammation in diet-induced obese mice. Benn T1, Kim B1, Park YK1, Wegner CJ1, Harness E1, Nam TG2, Kim DO2, Lee JS3, Lee JY4. J Nutr Biochem. 2014 Oct;25(10):1019-25. doi: 10.1016/j.jnutbio.2014.05.008. Epub 2014 Jun 13.

Evaluation of Beneficial Metabolic Effects of Berries in High-Fat Fed C57BL/6J Mice. Heyman L1, Axling U1, Blanco N2, Sterner O2, Holm C1, Berger K1. J Nutr Metab. 2014;2014:403041. doi: 10.1155/2014/403041. Epub 2014 Jan 14.

Berry components inhibit α-glucosidase in vitro: synergies between acarbose and polyphenols from black currant and rowanber-ry.Boath AS1, Stewart D, McDougall GJ. Food Chem. 2012 Dec 1;135(3):929-36. doi: 10.1016/j.foodchem.2012.06.065. Epub 2012 Jul 1.

Polyphenol-rich extract from blackcurrant pomace attenuates the intestinal tract and serum lipid changes induced by a high-fat diet in rabbits. Jurgoński A1, Juśkiewicz J, Zduńczyk Z, Matusevicius P, Kołodziejczyk K. Eur J Nutr. 2014 Dec;53(8):1603-13. doi: 10.1007/s00394-014-0665-4. Epub 2014 Feb 6.


Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects. Qin Y1, Xia M, Ma J, Hao Y, Liu J, Mou H, Cao L, Ling W. Am J Clin Nutr. 2009 Sep;90(3):485-92. doi: 10.3945/ ajcn.2009.27814. Epub 2009 Jul 29.

Polyphenol-rich blackcurrant extract exerts hypocholesterolaemic and hypoglycaemic effects in mice fed a diet containing high fat and cholesterol. Benn T1, Kim B1, Park YK1, Yang Y1, Pham TX1, Ku CS1, Farruggia C1, Harness E1, Smyth JA2, Lee JY1. Br J Nutr. 2015 Apr 22:1-7. [Epub ahead of print]


Cyanidin and cyanidin 3-O-beta-D-glucoside as DNA cleavage protectors and antioxidants. Acquaviva R, Russo A, Galvano F, et al. Cell Biol Toxicol. 2003;19(4):243–252.

Isolation and free-radical scavenging proper-ties of cyanidin 3-O-glycosides from the fruits of Ribes A. Delazar, L. Khodaie, J. Afshar,L. Nahar and S. D. Sarker, biebersteinii Berl,Acta. Pharm., 2010, 60, 1–11.

Anthocyanins from black currants (Ribes nigrum L.), R. Slimestad and H. Solheim, J. Agric.Food Chem., 2002, 50, 3228–3231.

The health benefits of blackcurrants Ashwin Gopalan,a Sharon C. Reuben,a Shamima Ahmed,a Altaf S. Darvesh,a Judit Hohmannb and Anupam Bishayee*c et al J Med Food. 2012 Dec;15(12):1045-50. doi: 10.1089/jmf.2011.0316. Epub 2012 Jun 27


Upregulation of endothelial nitric oxide synthase by cyanidin-3-glucoside, a typical anthocyanin pigment. Xu JW, Ikeda K, Yamori Y (2004). Hy-pertension 44, 217-222.

Effect of black currant anthocyanins on the activation of endothelial nitric oxide synthase (eNOS) in vitro in human endothelial cells. Edirisinghe I1, Banaszewski K, Cappozzo J, McCarthy D, Burton-Freeman BM. J Agric Food Chem. 2011 Aug 24;59(16):8616-24. doi: 10.1021/jf201116y. Epub 2011 Jul 28.

Effects of blackcurrant anthocyanin intake on peripheral muscle circulation during typing work in humans, H. Matsumoto, E. Takenami, K. Iwasaki-Kurashige, T. Osada, T. Katsumura and T.Hamaoka, Eur. J. Appl. Physiol., 2005, 94, 36–45.

Brain health

Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer’s disease. Vepsäläinen S1, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall GJ, Stewart D, Haapasalo A, Karjalainen RO, Tanila H, Hiltunen M. J Nutr Biochem. 2013 Jan;24(1):360-70. doi: 10.1016/j.jnutbio.2012.07.006. Epub 2012 Sep 17.

Acute supplementation with blackcurrant extracts modulates cognitive functioning and inhibits monoamine oxidase-B in healthy young adults Anthony W. Watsona, b, , , Crystal F. Haskell-Ramsaya, David O. Kennedya, Janine M. Cooneyb, Tania Trowerb, Arjan Scheepens. Journal of Functional Foods, Volume 17, August 2015, Pages 524-539

High fat meal increase of IL-17 is prevented by ingestion of fruit juice drink in healthy overweight subjects. Peluso I1, Raguzzini A, Villano DV, Cesqui E, Toti E, Catasta G, Serafini M. Curr Pharm Des. 2012;18(1):85-90.

Effects of anthocyanins and other phenolics of boysenberry and blackcurrant as inhibitors of oxidative stress and damage to cellular DNA in SH-SY5Y and HL-60 cells. Dilip Ghosh1,*, Tony K McGhie2, Jingli Zhang1, Aselle Adaim1 and Margot Skinner1. Journal of the Science of Food and Agriculture Volume 86, Issue 5, pages 678–686, 15 April 2006 Article first published online: 23 JAN 2006 DOI: 10.1002/jsfa.2409

Cytoprotective effects of anthocyanins and other phenolic fractions of Boysenberry and blackcurrant on dopamine and amyloid-induced oxidative stress in transfected COS-7 cells Dilip Ghosh, Tony K McGhie, Derek R Fisher, James A Joseph.Journal of the Science of Food and Agriculture

The impact of fruit flavonoids on memory and cognition. Spencer JP. Br J Nutr. 440 2010;104 Suppl 3; S40-7.

Neuroinflammation: modulation by flavonoids and mechanisms of action. Spencer JP1, Vafeiadou K, Williams RJ, Vauzour D. Mol Aspects Med. 2012 Feb;33(1):83-97. doi: 10.1016/j.mam.2011.10.016. Epub 2011 Nov 15.

The neuroprotective potential of flavonoids: a multiplicity of effects. Vauzour D1, Vafeiadou K, Rodriguez-Mateos A, Rendeiro C, Spencer JP Genes Nutr. 2008 Dec;3(3-4):115-26. doi: 10.1007/s12263-008-0091-4.Brain Res. 2014 Mar 25;1555:60-77. doi: 10.1016/j.brainres.2014.01.047. Epub 2014 Feb 3.

Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson’s disease. Strathearn KE1, Yousef GG2, Grace MH2, Roy SL1, Tambe MA1, Ferruzzi MG3, Wu QL4, Simon JE4, Lila MA2, Rochet JC5.

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Beneficial effects of berry fruit polyphenols on neuronal and behavioural aging. Lau, F. C., Shukitt-Hale,B. and Joseph, J. A. (2006) J. Sci. Food Agric. 86, 2251 – 2255.

Effect of flavonoids on learning, memory and neurocognitive performance: relevance and potential implications for Alzheimer’s disease pathophysiology. Vauzour D. J Sci Food Agric. 2014 Apr;94(6):1042-56. doi: 10.1002/jsfa.6473. Epub 2013 Dec 12.


Effect of blackcurrant anthocyanins on the activation of endothelial nitric oxide synthase (eNOS) in vitro in human endothelial cells, I.Edirisinghe, K.Banaszewski, J.Cappozzo, D.McCarthy and B.M.Burton-Freeman, J.AGRIC.FOOD CHEM., 2011, 59, 8616-8624

Purified Anthocyanin Supplementation Improves Endothelial Function via NO-cGMP activation in Hypercholesterolemic Individuals. Zhu, Yanna Xia, Min Yang, Yan Liu, FengqiongLi, ZhongxiaHao, YuantaMi, Mantia Jin, TianruLing, Wenhua, CLINICAL CHEMISTRY 2011, 57 1524-1533.

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Bioavailability and molecular activities of anthocyanins as modulators of endothelial function. Speciale A, Cimino F, Saija A, Canali R, Virgili F. Genes Nutr. 2014;9(4):404.

Delphinidin inhibits VEGF induced-mitochondrial biogenesis and Akt activation in endothelial cells. Duluc L1, Jacques C2, Soleti R3, Andriant¬sitohaina R4, Simard G5. Int J Biochem Cell Biol. 2014 Aug;53:9-14. doi: 10.1016/j.biocel.2014.03.030. Epub 2014 Apr 30.

Anthocyanin increases adiponectin secretion and protects against diabetes-related endothelial dysfunction. Liu Y, Li D, Zhang Y, Sun R, Xia M. Am J Physiol Endocrinol Metab. 2014;306(8):E975-88.

The endothelial plasma membrane transporter bilitranslocase mediates rat aortic vasodilation induced by anthocyanins. Ziberna L, Lunder M, Tramer F, Drevenšek G, Passamonti S. Nutr Metab Cardiovasc Dis. 2013;23(1):68-74.

Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease. Dalgård C1, Nielsen F, Morrow JD, Enghusen-Poulsen H, Jonung T, Hørder M, de Maat MP. Br J Nutr. 2009 Jan;101(2):263-9. doi: 10.1017/S0007114508995660. Epub 2008 May 28.

Intake of specific flavonoids and risk of acute myocardial infarction in Italy. Tavani, A., Spertini, L., Bosetti, C., Parpinel, M., Gnagnarella,P., Bravi, F., Peterson, J., Dwyer, J., Lagiou, P., Negri, E.and La Vecchia, C. (2006) Public HealthNutr. 9, 369 – 374.

RESEARCHJae H. Kang, Walter C. Willett, Bernard A. Rosner, Emmanuel Buys, Janey L. Wiggs, Louis R. Pasquale. Association of Dietary Nitrate Intake With Primary Open-Angle Glaucoma. JAMA Ophthalmology, 2016; 1 DOI: 10.1001/jamaophthalmol.2015.5601

St-Onge MP, Roberts A, Shechter A, Choudhury AR. Fiber and saturated fat are associated with sleep arousals and slow wave sleep. J Clin Sleep Med, 2016;12(1):19%u201324. DOI: 10.5664/jcsm.5384

Kelli A. Lytle, Donald B. Jump. Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible? PLOS ONE, 2016; 11 (1): e0146942 DOI: 10.1371/journal.pone.0146942

Erica D. Sonnenburg, Samuel A. Smits, Mikhail Tikhonov, Steven K. Higginbottom, Ned S. Wingreen, Justin L. Sonnenburg. Diet-induced extinctions in the gut microbiota compound over generations. Nature, 2016; 529 (7585): 212 DOI: 10.1038/nature16504

January 2016
December 2015


GBD 2013 Risk Factor Collaborators. Global, regional, and national comparative

risk assessment of 79 behavioural, environmental and occupational, and

metabolic risks or clusters of risks in 188 countries,1990–2013: a systematic

analysis for the Global Burden of Disease Study 2013.

Lancet. Published Online September 11, 2015

NEWSHomeopathyThere is no scientific case for homeopathy: the debate is over

Edzard Ernst: The Guardian, Thursday 12 March 2015:

House of Commons Science and Technology Committee – Fourth ReportEvidence Check 2: Homeopathy

YouTube video:

Update on Medical Practices That Should Be Questioned in 2015

Daniel J. Morgan, MD, MS1,2,3; Sanket S. Dhruva, MD4,5; Scott M. Wright, MD6; Deborah Korenstein, MD7

1Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore2Department of Hospital Epidemiology, Veterans Affairs Maryland Health Care System, Baltimore3Center for Disease Dynamics, Economics & Policy, Washington, DC4Robert Wood Johnson Foundation Clinical Scholars Program, Yale University School of Medicine, New Haven, Connecticut5Department of Veterans Affairs, West Haven, Connecticut6Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland7Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York

JAMA Intern Med. Published online November 09, 2015. doi:10.1001/jamainternmed.2015.5614).

Choosing Wisely in the UK: the Academy of Medical Royal Colleges’ initiative to reduce the harms of too much medicine

BMJ 2015; 350 doi: (Published 12 May 2015)



1. Murray PJ, Wivell G, Denton E. Breast cancer screening and diagnosis in the 21st century within the UK. Post Reprod Health. 2015 Sep;21(3):105-11.

Independent UK Panel on Breast Cancer Screening. The benefits and harms of breast cancer screening: an independent review. Lancet 2012; 380: 1778–1786.
3. Cavalieri EL, Rogan EG. Unbalanced metabolism of endogenous estrogens in the etiology and prevention of human cancer. J Steroid Biochem Mol Biol. 2011 Jul;125(3-5):169-80.4. Sepkovic DW, Bradlow HL. Estrogen hydroxylation–the good and the bad. Ann N Y Acad Sci. 2009 Feb;1155:57-67. 5. Sepkovic DW, Bradlow HL. Estrogen hydroxylation–the good and the bad. Ann N Y Acad Sci. 2009 Feb;1155:57-67.6. Fowke JH, Longcope C, Hebert JR. Brassica vegetable consumption shifts estrogen metabolism in healthy postmenopausal women. Cancer Epidemiol Biomarkers Prev. 2000 Aug;9(8):773-9. 7. Reding KW, Atkinson C, Westerlind KC, Stanczyk F, Bowles EJ, Yong M, Newton KM, Lampe JW. Fruit intake associated with urinary estrogen metabolites in healthy premenopausal women. Open J Prev Med. 2012 Feb 23;2(1).8. Reding KW, Zahid M, Cavalieri E, Rogan EG, Raccor BS, Atkinson C, Yong M, Newton KM, Lampe JW. Associations between Dietary Intake of Fruits and Vegetables in relation to Urinary Estrogen DNA Adduct Ratio. Open J Prev Med. 2014 Jun;4(6):429-437.

Muran PJ, Muran SY, Beseler CL, Cavalieri EL, Rogan EG, Zahid M. Breast health and reducing breast cancer risk: a functional medicine approach. J Altern Complement Med. 2015 Jun;21(6):321-6.


Szyf, M.. DNA methylation properties: consequences for pharmacology. Trends Pharmacol Sci 15: 233-238.

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Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide.

Ramchandani S1, MacLeod AR, Pinard M, von Hofe E, Szyf M.

Nature. 1999 Feb 18;397(6720):579-83.

A mammalian protein with specific demethylase activity for mCpG DNA.

Bhattacharya SK1, Ramchandani S, Cervoni N, Szyf M.

Lei Cao-Lei, Renaud Massart, Matthew J. Suderman, Ziv Machnes, Guillaume Elgbeili, David P. Laplante, Moshe Szyf, Suzanne King. DNA Methylation Signatures Triggered by Prenatal Maternal Stress Exposure to a Natural Disaster: Project Ice Storm. PLoS ONE, 2014; 9 (9): e107653 DOI: 10.1371/journal.pone.0107653.

J Nutr. 2002 Aug;132(8 Suppl):2333S-2335S.Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline. Niculescu MD1, Zeisel SH.

J Neurosci. 2005 Nov 23;25(47):11045-54. Free online at : of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life.Weaver IC1, Champagne FA, Brown SE, Dymov S, Sharma S, Meaney MJ, Szyf M.

Brain Res. 2008 Oct 27;1237:12-24. doi: 10.1016/j.brainres.2008.07.074. Epub 2008 Jul 29. Diet and the epigenetic (re)programming of phenotypic differences in behavior.

McGowan PO1, Meaney MJ, Szyf M.

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Chew EY, et al. Effect of omega-3 fatty acids, lutein/zeaxanthin, or other nutrient supplementation on cognitive function: The AREDS2 randomized clinical trial. JAMA 2015;314:791-801. 18 September 2015:Vol. 349 no. 6254 pp. 1343-1347DOI: 10.1126/science.aab2319

Greenlandic Inuit show genetic signatures of diet and climate adaptation

Matteo Fumagalli et al

RESEARCHEfficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Elderly: A Randomized, Double-Blind, Placebo-Controlled Trial

Liu, Guosonga; d; * | Weinger, Jason G.a | Lu, Zhong-Linb | Xue, Fengc | Sadeghpour, Safaa

Journal of Alzheimer’s Disease, vol. Preprint, no. Preprint, pp. 1-19, 2015

David Just and Brian Wansink (2015). Fast Food, Soft Drink, and Candy Intake is Unrelated to Body Mass Index for 95% of American Adults. Obesity Science & Practice, forthcoming.

Ayelet Sivan, Leticia Corrales, Nathaniel Hubert, Jason B. Williams, Keston Aquino-Michaels, Zachary M. Earley, Franco W. Benyamin, Yuk Man Lei, Bana Jabri, Maria-Luisa Alegre, Eugene B. Chang, and Thomas F. Gajewski. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy. Science, November 2015 DOI: 10.1126/science.aac4255

Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseases

Bidisha Paul et al. Clinical Epigenetics 2015, 7:112

(doi: 10.1186/s13148-015-0144-7)

Matzkin, K. Suslavich, E. J. Curry. Lyme Disease Presenting as a Spontaneous Knee Effusion. Journal of the American Academy of Orthopaedic Surgeons, 2015; 23 (11): 674 DOI: 10.5435/JAAOS-D-14-00388
Carol Kumamoto et al. Manipulation of Host Diet To Reduce Gastrointestinal Colonization by the Opportunistic Pathogen Candida albicans. mSphere, November 2015 DOI: 10.1128/mSphere.00020-15

Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study Ulla Uusitalo, et al for the TEDDY Study Group

JAMA Pediatr. Published online November 09, 2015. doi:10.1001/jamapediatrics.2015.2757

Efficacy of Bright Light Treatment, Fluoxetine, and the Combination in Patients With Nonseasonal Major Depressive Disorder: A Randomized Clinical Trial.Raymond W. Lam, et al.

JAMA Psychiatry. Published online November 18, 2015.


A. Kenfield, J. L. Batista, J. L. Jahn, M. K. Downer, E. L. Van Blarigan, H. D. Sesso, E. L. Giovannucci, M. J. Stampfer, J. M. Chan. Development and Application of a Lifestyle Score for Prevention of Lethal Prostate Cancer. JNCI Journal of the National Cancer Institute, 2015; 108 (3): djv329 DOI: 10.1093/jnci/djv329

November 2015
October 2015


Peng Li, Stephanie C. Tjen-A-Looi, Ling Cheng, Dongmei Liu, Jeannette Painovich, Sivarama Vinjamury, John C. Longhurst. Long-Lasting Reduction of Blood Pressure by Electroacupuncture in Patients with Hypertension: Randomized Controlled Trial. Medical Acupuncture, 2015; 27 (4): 253 DOI: 10.1089/acu.2015.1106

BMC Biol. 2014; 12: 8. Published online 2013 Jan 31. doi: 10.1186/1741-7007-12-8

PMCID: PMC3909335. Cancer, metabolism, fructose, artificial sweeteners, and going cold turkey on sugar. Lewis C Cantley.

doi: 10.1186/1741-7007-12-8

Peng Li, Stephanie C. Tjen-A-Looi, Ling Cheng, Dongmei Liu, Jeannette Painovich, Sivarama Vinjamury, John C. Longhurst. Long-Lasting Reduction of Blood Pressure by Electroacupuncture in Patients with Hypertension: Randomized Controlled Trial. Medical Acupuncture, 2015; 27 (4): 253 DOI: 10.1089/acu.2015.1106

Rebecca I. Clark, Anna Salazar, Ryuichi Yamada, Sorel Fitz-Gibbon, Marco Morselli, Jeanette Alcaraz, Anil Rana, Michael Rera, Matteo Pellegrini, William W. Ja, David W. Walker. Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality. Cell Reports, 2015; 12 (10): 1656 DOI: 10.1016/j.celrep.2015.08.004.

BEN BROWN – Inflammation

1. Bested AC, Logan AC, Selhub EM. Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: Part I – autointoxication revisited. Gut Pathog. 2013 Mar 18;5(1):5. 2. Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, Neyrinck AM, Fava F, Tuohy KM, Chabo C, Waget A, Delmée E, Cousin B, Sulpice T, Chamontin B, Ferrières J, Tanti JF, Gibson GR, Casteilla L, Delzenne NM, Alessi MC, Burcelin R. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007 Jul;56(7):1761-72.3. Egger G, Dixon J. Beyond obesity and lifestyle: a review of 21st century chronic disease determinants. Biomed Res Int. 2014;2014:731685.4. Cani PD, Delzenne NM. The gut microbiome as therapeutic target. Pharmacol Ther. 2011 May;130(2):202-12.5. Amar J, Burcelin R, Ruidavets JB, Cani PD, Fauvel J, Alessi MC, Chamontin B, Ferriéres J. Energy intake is associated with endotoxemia in apparently healthy men. Am J Clin Nutr. 2008 May;87(5):1219-23.6. Ghanim H, Abuaysheh S, Sia CL, Korzeniewski K, Chaudhuri A, Fernandez-Real JM, Dandona P. Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance. Diabetes Care. 2009 Dec;32(12):2281-7

Pendyala S, Walker JM, Holt PR. A high-fat diet is associated with endotoxemia that originates from the gut. Gastroenterology. 2012 May;142(5):1100-1101.e2. doi: 10.1053/j.gastro.2012.01.034.
Xiao S, Fei N, Pang X, Shen J, Wang L, Zhang B, Zhang M, Zhang X, Zhang C, Li M, Sun L, Xue Z, Wang J, Feng J, Yan F, Zhao N, Liu J, Long W, Zhao L. A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome. FEMS Microbiol Ecol. 2014 Feb;87(2):357-67.
9. Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett. 2008 Dec;29(6):902-10.10. Albenberg LG, Wu GD. Diet and the intestinal microbiome: associations, functions, and implications for health and disease. Gastroenterology. 2014 May;146(6):1564-72.

Chassaing B, et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 2015 Mar 5;519(7541):92-6
12. David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA, Biddinger SB, Dutton RJ, Turnbaugh PJ. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014 Jan 23;505(7484):559-63.13. Dehghan P, Pourghassem Gargari B, Asghari Jafar-abadi M. Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized controlled clinical trial. Nutrition. 2014 Apr;30(4):418-23.14. Simon MC, Strassburger K, Nowotny B, Kolb H, Nowotny P, Burkart V, Zivehe F, Hwang JH, Stehle P, Pacini G, Hartmann B, Holst JJ, MacKenzie C, Bindels LB, Martinez I, Walter J, Henrich B, Schloot NC, Roden M. Intake of Lactobacillus reuteri Improves Incretin and Insulin Secretion in Glucose Tolerant Humans: A Proof of Concept. Diabetes Care. 2015 Jun 17. pii: dc142690. [Epub ahead of print]15. Sellmann C, Jin CJ, Degen C, De Bandt JP, Bergheim I. Oral Glutamine Supplementation Protects Female Mice from Nonalcoholic Steatohepatitis. J Nutr. 2015 Aug 5. pii: jn215517. [Epub ahead of print]16. de Souza AZ, Zambom AZ, Abboud KY, Reis SK, Tannihão F, Guadagnini D, Saad MJ, Prada PO. Oral supplementation with L-glutamine alters gut microbiota of obese and overweight adults: A pilot study. Nutrition. 2015 Jun;31(6):884-9.

Brimelow RE, et al. A Role for Whey-derived Lactoferrin and Immunoglobulins in the Attenuation of Obesity-related Inflammation and Disease? Crit Rev Food Sci Nutr. 2015 Jun 11:0. [Epub ahead of print]

Emma Lane – parasites

Crompton, D.W.T. 1999. How much human helminthiasis is there in the world? Journal of Parasitology 85(3): 397-403; The World Health Organization; and various additional published reviews

Journal of Parasitology 85:379-403 Dr. D.W.T. Crompton (Crompton, D.W.T. [1999How much human helminthiasis is there in the world?)

Gillespie S and Pearson R. Principles and Practice of Clinical Parasitology. John Wiley & Sons, Ltd. Chichester. ISBN: 0-471-97729-2. 2001

Leventhal R and Cheadle R. Medical Parasitology, A Self Instructional Text 6th Edition. F A Davis Company. Philadelphia. ISBN: 978-0-8036-2543-3. 2012.

Bush A, Fernandez J, Esch G and Seed J. Parasitism, The diversity and ecology of animal parasites. Cambridge University Press. Cambridge. ISBN: 0-521-66447-0. 2001.

Baron S. Medical Microbiology 4th Edition. University of Texas Medical Branch. Galveston. ISBN: 0-9631172-1-1. 1996

Mullin G. Integrative Gastroenterology. Oxford University Press. New York. ISBN 978-0-19537110-9. 2011.

Wright J and Lenard L. Why stomach acid is good for you. M. Evans and Company, Inc. New York. ISBN: 0-87131-931-4. 2001.

Pizzorno Jr J, Murray M and Joiner-Bey H. The Clinician’s Handbook of Natural Medicine 2nd Edition. Churchill Livingstone. Missouri. ISBN: 978-0-443-06723-5. 2008.

Liska D, Quinn S, Lukaczer D, Jones D and Lerman R. Clinical Nutrition, A Functional Approach. 2nd Edition. The Institute for Functional Medicine. Washington. ISBN: 978-0-9773713-2-7. 2006.

Lord R and Bralley J. Laboratory Evaluations for Integrative and Functional Medicine 2nd Edition. Genova Diagnostics. Duluth. ISBN: 978-0-9884322-0-8. 2012.

Lipski E. Digestive Wellness 4th Edition. McGraw Hill. New York. ISBN 978-0-07-166899-6. 2012.

The significance of bio-markers in the interpretation of comprehensive stool analysis results. By Omar M. Amin, B.Sc., M.Sc., Ph.D., USA Explore! Volume 20, Number 2, 2011

Detecting Microbes, By Omar M. Amin, B.Sc., M.Sc., Ph.D., USA, Chapter 15 of Optimal Digestive Heath – A Complete Guide, edited by Trent W Nichols, MD, and Nancy Faass, MSW MPH. Published by Healing Arts Press, Rochester Vermont Copyright 1999, 2005 by Nancy Faass and by Trent W Nichols, M.D.

Prevalence, Distribution, and Host Relationships of Cryptosporidium Parvum (Protozoa)
Infections in the United States, 2003-2005 © By Omar M. Amin, B.SC., M.SC., Ph.D., USA Explore! Volume 16, Number 1, 2006

The Epidemiology of Blastocystis horminis in the United States, By Omar M. Amin, B.Sc., M.Sc., Ph.D., USA, Research Journal of Parasitology 1 (1): 1-10, 2006

Prevalence, Distribution and Host Relationships of Cryptosporidium Parvum (Protozoa) Infections in the United States, 2003 – 2005 © By Omar M. Amin, B.SC., M.SC., Ph.D., USA . Explore! Volume 16, Number 1, 2006


Mingguang He, Fan Xiang, Yangfa Zeng, Jincheng Mai, Qianyun Chen, Jian Zhang, Wayne Smith, Kathryn Rose, Ian G. Morgan. Effect of Time Spent Outdoors at School on the Development of Myopia Among Children in China. JAMA, 2015; 314 (11): 1142 DOI: 10.1001/jama.2015.10803

Michael X. Repka. Prevention of Myopia in Children. JAMA, 2015; 314 (11): 1137 DOI: 10.1001/jama.2015.10723

Logan NS, Davies LN, Mallen EA, Gilmartin B; Davies; Mallen; Gilmartin (April 2005). “Ametropia and ocular biometry in a U.K. university student population”. Optom Vis Sci 82 (4): 261–6. doi:10.1097/01.OPX.0000159358.71125.95. PMID 15829853.

Mokry LE, Ross S, Ahmad OS, Forgetta V, Smith GD, Leong A, et al. Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study. PLoS Med, 2015 DOI: 10.1371/journal.pmed.1001866

Ramagopalan SV, Heger A, Berlanga AJ, Maugeri NJ, Lincoln MR, Burrell A, Handunnetthi L, Handel AE, Disanto G, Orton S, Watson CT, Morahan JM, Giovannoni G, Ponting CP, Ebers GC, Knight JC. A ChIP-seq-defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution. Genome Research, 2010; DOI: 10.1101/gr.107920.110

McManus A et al (2015) Impact of prolonged sitting on vascular function in young girls. DOI: 10.1113/EP085355

Cell Matbolism. Volume 22, Issue 2, p320–331, 4 August 2015. Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome

Saeed Shoaie et al. DOI:

Tanya J Flynn, Murray Cadzow, Nicola Dalbeth, Peter B Jones, Lisa K Stamp, Jennie Harré Hindmarsh, Alwyn S Todd, Robert J Walker, Ruth Topless, Tony R Merriman. Positive association of tomato consumption with serum urate: support for tomato consumption as an anecdotal trigger of gout flares. BMC Musculoskeletal Disorders, 2015; 16 (1) DOI: 10.1186/s12891-015-0661-8

Paul S. Frenette et al. Neutrophil ageing is regulated by the microbiome. Nature, September 2015 DOI: 10.1038/nature15367.

S.A. Kim, H. Moon, K. Lee and M.S. Rhee. Bactericidal effects of triclosan in soap both in vitro and in vivo. Journal of Antimicrobial Chemotherapy, September 2015 DOI: 10.1093/jac/dkv275.

H. Moonaz, C. O. Bingham, L. Wissow, S. J. Bartlett. Yoga in Sedentary Adults with Arthritis: Effects of a Randomized Controlled Pragmatic Trial. The Journal of Rheumatology, 2015; 42 (7): 1194 DOI: 10.3899/jrheum.141129.

Liuyang Wang, Stefan H. Oehlers, Scott T. Espenschied, John F. Rawls, David M. Tobin, Dennis C. Ko. CPAG: software for leveraging pleiotropy in GWAS to reveal similarity between human traits links plasma fatty acids and intestinal inflammation. Genome Biology, 2015; 16 (1) DOI: 10.1186/s13059-015-0722-1

Estefanía Toledo, Jordi Salas-Salvadó, Carolina Donat-Vargas, Pilar Buil-Cosiales, Ramón Estruch, Emilio Ros, Dolores Corella, Montserrat Fitó, Frank B. Hu, Fernando Arós, Enrique Gómez-Gracia, Dora Romaguera, Manuel Ortega-Calvo, Lluís Serra-Majem, Xavier Pintó, Helmut Schröder, Josep Basora, José Vicente Sorlí, Mònica Bulló, Merce Serra-Mir, Miguel A. Martínez-González. Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial. JAMA Internal Medicine, 2015; 1 DOI: 10.1001/jamainternmed.2015.4838
S. Turner, R. G. Thomas, S. Craft, C. H. van Dyck, J. Mintzer, B. A. Reynolds, J. B. Brewer, R. A. Rissman, R. Raman, P. S. Aisen. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology, 2015; DOI: 10.1212/WNL.0000000000002035

September 2015


1. Karell K, Louka AS, Moodie SJ, Ascher H, Clot F, Greco L, Ciclitira PJ, Sollid LM, Partanen J; European Genetics Cluster on Coeliac Disease. HLA types in coeliac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Coeliac Disease. Hum Immunol. 2003 Apr;64(4):469-77.2. Trynka G, Hunt KA, Bockett NA, et al. Dense genotyping identifies and localizes multiple common and rare variant association signals in coeliac disease. Nat Genet. 2011 Nov 6;43(12):1193-201.3. Lohi S, Mustalahti K, Kaukinen K, Laurila K, Collin P, Rissanen H, Lohi O, Bravi E, Gasparin M, Reunanen A, Mäki M. Increasing prevalence of coeliac disease over time. Aliment Pharmacol Ther. 2007 Nov 1;26(9):1217-25.4. Catassi C, Kryszak D, Bhatti B, Sturgeon C, Helzlsouer K, Clipp SL, Gelfond D, Puppa E, Sferruzza A, Fasano A. Natural history of coeliac disease autoimmunity in a USA cohort followed since 1974. Ann Med. 2010 Oct;42(7):530-8.5. West J, Fleming KM, Tata LJ, Card TR, Crooks CJ. Incidence and prevalence of coeliac disease and dermatitis herpetiformis in the UK over two decades: population-based study. Am J Gastroenterol. 2014 May;109(5):757-68.6. Kasarda DD. Can an increase in coeliac disease be attributed to an increase in the gluten content of wheat as a consequence of wheat breeding? J Agric Food Chem. 2013 Feb 13;61(6):1155-9.7. Freeman HJ. Coeliac disease: a disorder emerging from antiquity, its evolving classification and risk, and potential new treatment paradigms. Gut Liver. 2015 Jan;9(1):28-37.8. Størdal K, Haugen M, Brantsæter AL, Lundin KE, Stene LC. Association between maternal iron supplementation during pregnancy and risk of coeliac disease in children. Clin Gastroenterol Hepatol. 2014 Apr;12(4):624-31.e1-2.

Ludvigsson JF, Murray JA, Adams PC, et al. Does hemochromatosis predispose to coeliac disease? A study of 29,096 coeliac disease patients. Scand J Gastroenterol. 2013;48:176–182
10. Tanpowpong P, Obuch JC, Jiang H, McCarty CE, Katz AJ, Leffler DA, Kelly CP, Weir DC, Leichtner AM, Camargo CA Jr. Multicenter study on season of birth and coeliac disease: evidence for a new theoretical model of pathogenesis. J Pediatr. 2013 Mar;162(3):501-4.11. Ivarsson A, Hernell O, Nyström L, Persson LA. Children born in the summer have increased risk for coeliac disease. J Epidemiol Community Health. 2003 Jan;57(1):36-9.12. Lebwohl B, Green PH, Murray JA, Ludvigsson JF. Season of birth in a nationwide cohort of coeliac disease patients. Arch Dis Child. 2013 Jan;98(1):48-51.13. Tanpowpong P, Camargo CA. Early-life vitamin D deficiency and childhood-onset coeliac disease. Public Health Nutr. 2014 Apr;17(4):823-6.

Sandberg-Bennich S, Dahlquist G, Ka¨lle´n B. Coeliac disease is associated with intrauterine growth and neonatal infections. Acta Paediatr. 2002;91:30–33.
Myle´us A, Hernell O, Gothefors L, et al. Early infections are associated with increased risk for coeliac disease: an incident casereferent study. BMC Pediatr. 2012;19(12):194.
Riddle MS, Murray JA, Cash BD, Pimentel M, Porter CK. Pathogen-specific risk of coeliac disease following bacterial causes of foodborne illness: a retrospective cohort study. Dig Dis Sci. 2013 Nov;58(11):3242-5.
17. Keenan JI, Day AS. Risks for coeliac disease: bacteria make it three. Dig Dis Sci. 2013 Nov;58(11):3066-7.18. Lebwohl B, Ludvigsson JF, Green PH. The unfolding story of coeliac disease risk factors. Clin Gastroenterol Hepatol. 2014 Apr;12(4):632-


M Hornig, G Gottschalk, D L Peterson, K K Knox, A F Schultz, M L Eddy, X Che, W I Lipkin. Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome. Molecular Psychiatry, 2015; DOI: 10.1038/mp.2015.29

Roumiana S. Boneva, Jin-Mann S. Lin, Elizabeth R. Unger. Early menopause and other gynecologic risk indicators for chronic fatigue syndrome in women. Menopause, 2015; 1 DOI: 10.1097/GME.0000000000000411

Mady Hornig, José G. Montoya, Nancy G. Klimas, Susan Levine, Donna Felsenstein, Lucinda Bateman, Daniel L. Peterson, C. Gunnar Gottschalk, Andrew F. Schultz, Xiaoyu Che, Meredith L. Eddy, Anthony L. Komaroff, W. Ian Lipkin. Distinct plasma immune signatures in ME/CFS are present early in the course of illness. Science Advances, 2015 DOI: 10.1126/sciadv.1400121Anne Pemberton

Bosque P. Vitamin B12 deficiency – Epidemiology. Medmerits [Internet]. 2014 [cited 2015 Aug 15]; Available from:
Healton EB, Savage DG, Brust JC, Garrett TJ, Lindenbaum J. Neurologic aspects of cobalamin deficiency. Medicine (Baltimore) [Internet]. 1991 Jul [cited 2015 Aug 15];70(4):229–45. Available from:
Goringe A, Ellis R, McDowell I, et al. The limited value of methylmalonic acid, homocysteine and holotranscobalamin in the diagnosis of early B12 deficiency. Haematologica 2006;91:231-4.
Mitchell ES, Conus N, Kaput J. B vitamin polymorphisms and behavior: evidence of associations with neurodevelopment, depression, schizophrenia, bipolar disorder and cognitive decline. Neurosci Biobehav Rev [Internet]. 2014 Nov [cited 2015 Aug 15];47:307–20. Available from:

BMC Complement Altern Med. 2011; 11: 16.

Published online 2011 Feb 25. doi: 10.1186/1472-6882-11-16

PMCID: PMC3056848

Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses

Christian Krawitz,#

Global Information Hub on Integrated Medicine entry on elderberry:

ANTIOXIDANTSUnraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits

Michael Ristow Nature Medicine 20, 709–711 (2014)


How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

Michael Ristowa, b, , , Kim Zarsea Experimental Gerontology (doi:10.1038/nm.3624). Volume 45, Issue 6, June 2010, Pages 410–418

Cell Death and Differentiation (2015) 22, 377–388; doi:10.1038/cdd.2014.150; published online 26 September 2014. Oxidative stress and autophagy: the clash between damage and metabolic needsG Filomeni1,2, D De Zio1,2 and F Cecconi1,2

Hum Mol Genet. 2010 Sep 1; 19(17): 3413–3429.

Published online 2010 Jun 21. doi: 10.1093/hmg/ddq253

PMCID: PMC2916709

Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease

Benjamin R. Underwood,1 Sara Imarisio,1,2 Angeleen Fleming,1,3 Claudia Rose,1 Gauri Krishna,1,2 Phoebe Heard,2 Marie Quick,1,3 Viktor I. Korolchuk,1 Maurizio Renna,1 Sovan Sarkar,1 Moisés García-Arencibia,1 Cahir J. O’Kane,2 Michael P. Murphy,4 and David C. Rubinsztein1,*

Orthop Res. 2014 Jul;32(7):937-43. doi: 10.1002/jor.22608. Epub 2014 Mar 18.

Do antioxidants inhibit oxidative-stress-induced autophagy of tenofibroblasts?

Kim RJ1, Hah YS, Sung CM, Kang JR, Park HB.

Am J Clin Nutr 2005, vol. 81 no. 1 215S-217S Polyphenols: antioxidants and beyond.

Augustin Scalbert,

Ian T Johnson, and

Mike Saltmarsh

Med Sci Monit. 2008 Nov;14(11):CR547-51.

Vitamin C-lipid metabolites: uptake and retention and effect on plasma C-reactive protein and oxidized LDL levels in healthy volunteers.

Pancorbo D1, Vazquez C, Fletcher MA.

Suhong Xu, Andrew D. Chisholm. C. elegans Epidermal Wounding Induces a Mitochondrial ROS Burst that Promotes Wound Repair. Developmental Cell, 2014; 31 (1): 48 DOI: 10.1016/j.devcel.2014.08.002

mtDNA Mutagenesis Disrupts Pluripotent Stem Cell Function by Altering Redox Signaling. C

Riikka H. Hämäläinen,

Kati J. Ahlqvist,

Pekka Ellonen

Maija Lepistö,

Angela Logan,

Timo Otonkoski,

Michael P. Murphy,

Anu Suomalainen

Open Access

Cell Reports, Volume 11, Issue 10, p1614–1624, 16 June 2015 DOI:


Brendan J. Guercio, Kaori Sato, Donna Niedzwiecki, Xing Ye, Leonard B. Saltz, Robert J. Mayer, Rex B. Mowat, Renaud Whittom, Alexander Hantel, Al Benson, Daniel Atienza, Michael Messino, Hedy Kindler, Alan Venook, Frank B. Hu, Shuji Ogino, Kana Wu, Walter C. Willett, Edward L. Giovannucci, Jeffrey A. Meyerhardt, and Charles S. Fuchs. Coffee Intake, Recurrence, and Mortality in Stage III Colon Cancer: Results From CALGB 89803 (Alliance). Journal of Clinical Oncology, August 2015 DOI: 10.1200/JCO.2015.61.5062

Saccharomyces boulardii CNCM I-745 supports regeneration of the intestinal microbiota after diarrheic dysbiosis – a review. Moré MI, Swidsinski A

Clinical and Experimental Gastroenterology August 2015 Volume 2015:8 Pages 237—255 DOI

The Effect of Body Posture on Brain Glymphatic Transport

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Science 18 October 2013: Vol. 342 no. 6156 pp. 373-377 DOI: 10.1126/science.1241224. Sleep Drives Metabolite Clearance from the Adult Brain

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Gail D. Sckisel, Myriam N. Bouchlaka, Arta M. Monjazeb, Marka Crittenden, Brendan D. Curti, Danice E.C. Wilkins, Kory A. Alderson, Can M. Sungur, Erik Ames, Annie Mirsoian, Abhinav Reddy, Warren Alexander, Athena Soulika, Bruce R. Blazar, Dan L. Longo, Robert H. Wiltrout, William J. Murphy. Out-of-Sequence Signal 3 Paralyzes Primary CD4 T-Cell-Dependent Immunity. Immunity, 2015; 43 (2): 240 DOI: 10.1016/j.immuni.2015.06.023

Reiko Horai, Carlos R. Zárate-Bladés, Patricia Dillenburg-Pilla, Jun Chen, Jennifer L. Kielczewski, Phyllis B. Silver, Yingyos Jittayasothorn, Chi-Chao Chan, Hidehiro Yamane, Kenya Honda, Rachel R. Caspi. Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site. Immunity, 2015; 43 (2): 343 DOI: 10.1016/j.immuni.2015.07.014

Laura Steenbergen, Roberta Sellaro, Ann-Kathrin Stock, Christian Beste, Lorenza S. Colzato. γ-Aminobutyric acid (GABA) administration improves action selection processes: a randomised controlled trial. Scientific Reports, 2015; 5: 12770 DOI: 10.1038/srep12770

Denise K. Houston, Janet A. Tooze, Jamehl L. Demons, Brooke L. Davis, Rachel Shertzer-Skinner, Linda B. Kearsley, Stephen B. Kritchevsky, Jeff D. Williamson. Delivery of a Vitamin D Intervention in Homebound Older Adults Using a Meals-on-Wheels Program: A Pilot Study. Journal of the American Geriatrics Society, 2015; DOI: 10.1111/jgs.13610

Kevin D. Hall, Thomas Bemis, Robert Brychta, Kong Y. Chen, Amber Courville, Emma J. Crayner, Stephanie Goodwin, Juen Guo, Lilian Howard, Nicolas D. Knuth, Bernard V. Miller, Carla M. Prado, Mario Siervo, Monica C. Skarulis, Mary Walter, Peter J. Walter, Laura Yannai. Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity. Cell Metabolism, 2015; DOI: 10.1016/j.cmet.2015.07.021

August 2015


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NEWSGluten psychosis: confirmation of a new clinical entity

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Brianna Cote, Lisa Janssen Carlson, Deepa A. Rao, Adam W.G. Alani. Combinatorial resveratrol and quercetin polymeric micelles mitigate doxorubicin induced cardiotoxicity in vitro and in vivo. Journal of Controlled Release, 2015; 213: 128 DOI: 10.1016/j.jconrel.2015.06.040

Strekalova, D. Malin, D. M. Good, V. L. Cryns. Methionine Deprivation Induces a Targetable Vulnerability in Triple-Negative Breast Cancer Cells by Enhancing TRAIL Receptor-2 Expression. Clinical Cancer Research, 2015; 21 (12): 2780 DOI: 10.1158/1078-0432.CCR-14-2792
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Nneka M. George, Julia Whitaker, Giovana Vieira, Jerome T. Geronimo, Dwight A. Bellinger, Craig A. Fletcher, Joseph P. Garner. Antioxidant Therapies for Ulcerative Dermatitis: A Potential Model for Skin Picking Disorder. PLOS ONE, 2015 DOI: 10.1371/journal.pone.0132092

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Jaewoo Choi, Scott W. Leonard, Katherine Kasper, Melissa McDougall, Jan F. Stevens, Robert L. Tanguay, Maret G. Traber. Novel function of vitamin E in regulation of zebrafish (Danio rerio) brain lysophospholipids discovered using lipidomics. Journal of Lipid Research, 2015; jlr.M058941 DOI: 10.1194/jlr.M058941

Aron Barbey et al. Anterior cingulate cortex mediates the relationship between O3PUFAs and executive functions in APOE e4 carriers. Frontiers in Aging Neuroscience, May 2015 DOI: 10.3389/fnagi.2015.00087

Adrian Raine, Jill Portnoy, Jianghong Liu, Tashneem Mahoomed, Joseph R. Hibbeln. Reduction in behaviour problems with omega-3 supplementation in children aged 8-16 years: a randomized, double-blind, placebo-controlled, stratified, parallel-group trial. Journal of Child Psychology and Psychiatry, 2015; 56 (5): 509 DOI: 10.1111/jcpp.12314

Gong Cheng, Changzhen Fu, Hong Wang, C. Adoligbe, Shengjuan Wei, Shijun Li, Bijie Jiang, Hongbao Wang, Linsen Zan. Production of transgenic beef cattle rich in n-3 PUFAs by somatic cell nuclear transfer. Biotechnology Letters, 2015; DOI: 10.1007/s10529-015-1827-z

Hanna Shevalye, Matthew S Yorek, Lawrence J Coppey, Amey Holmes, Matthew M Harper, Randy H Kardon, Mark A. Yorek. Effect of enriching the diet with menhaden oil or daily treatment with resolvin D1 on neuropathy in a mouse model of type 2 diabetes. Journal of Neurophysiology, 2015; jn.00224.2015 DOI: 10.1152/jn.00224.2015

Xiaoming Jia, Mohammadreza Pakseresht, Nour Wattar, Jamie Wildgrube, Stephanie Sontag, Murphy Andrews, Fatheema Begum Subhan, Linda McCargar, Catherine J. Field. Women who take n-3 long-chain polyunsaturated fatty acid supplements during pregnancy and lactation meet the recommended intake. Applied Physiology, Nutrition, and Metabolism, 2015; 1 DOI: 10.1139/apnm-2014-0313

Molecular Psychiatry advance online publication 24 March 2015; doi: 10.1038/mp.2015.22).Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept studyM H Rapaport1, A A Nierenberg2, P J Schettler1, B Kinkead1, A Cardoos2, R Walker2 and D Mischoulon2


Bäckhed et al. Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life. Cell Host & Microbe, May 2015 DOI: 10.1016/j.chom.2015.04.004

Vangay et al. Antibiotics, Pediatric Dysbiosis, and Disease. Cell Host & Microbe, May 2015 DOI: 10.1016/j.chom.2015.04.006

Fujimura et al. Microbiota in Allergy and Asthma and the Emerging Relationship with the Gut Microbiome. Cell Host & Microbe, May 2015 DOI: 10.1016/j.chom.2015.04.007

Vandana Gulati, Pankaj Gulati, Ian H Harding, Enzo A Palombo. Exploring the anti- diabetic potential of Australian Aboriginal and Indian Ayurvedic plant extracts using cell-based assays. BMC Complementary and Alternative Medicine, 2015; 15 (1) DOI: 10.1186/s12906-015-0524-8

Esther Lopez-Garcia, Luz Leon-Muñoz, Pilar Guallar-Castillon, Fernando Rodríguez-Artalejo. Habitual Yoghurt Consumption and Health-Related Quality of Life: A Prospective Cohort Study. Journal of the Academy of Nutrition and Dietetics, 2015; 115 (1): 31 DOI: 10.1016/j.jand.2014.05.013

May 2015

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Am J Clin Dermatol. 2008;9(2):93-103. GUT HEALTH and RESEARCH UPDATE Junki Miyamoto, Taichi Mizukure, Si-Bum Park, Shigenobu Kishino, Ikuo Kimura, Kanako Hirano, Paolo Bergamo, Mauro Rossi, Takuya Suzuki, Makoto Arita, Jun Ogawa, Soichi Tanabe. A Gut Microbial Metabolite of Linoleic Acid, 10-Hydroxy-cis-12-octadecenoic Acid, Ameliorates Intestinal Epithelial Barrier Impairment Partially via GPR40-MEK-ERK Pathway. Journal of Biological Chemistry, 2015; 290 (5): 2902 DOI: 10.1074/jbc.M114.610733 Am J Obstet Gynecol. 2015 Feb 14. pii: S0002-9378(15)00130-1. doi: 10.1016/j.ajog.2015.02.008. [Epub ahead of print] Impact of probiotics in women with gestational diabetes mellitus on metabolic health: a randomized controlled trial. Lindsay KL1, Brennan L2, Kennelly MA1, Maguire OC3, Smith T3, Curran S4, Coffey M5, Foley ME1, Hatunic M6, Shanahan F7, McAuliffe FM8. 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Omega-3 Fatty Acids and Other FFA4 Agonists Inhibit Growth Factor Signaling in Human Prostate Cancer Cells. Journal of Pharmacology and Experimental Therapeutics, 2014; 352 (2): 380 DOI: 10.1124/jpet.114.218974 Shaiju K. Vareed, Alison K. Bauer, Kavitha M. Nair, Yunbao Liu, Bolleddula Jayaprakasam, Muraleedharan G. Nair. Blood-Brain Barrier Permeability of Bioactive Withanamides Present in Withania somnifera Fruit Extract. Phytotherapy Research, 2014; 28 (8): 1260 DOI: 10.1002/ptr.5118 1. M. B. Azad, T. Konya, D. S. Guttman, C. J. Field, M. R. Sears, K. T. HayGlass, P. J. Mandhane, S. E. Turvey, P. Subbarao, A. B. Becker, J. A. Scott, A. L. Kozyrskyj. Infant gut microbiota and food sensitization: associations in the first year of life. Clinical & Experimental Allergy, 2015; 45 (3): 632 DOI: 10.1111/cea.12487 NEWS Benoit Chassaing, Omry Koren, Julia K. Goodrich, Angela C. Poole, Shanthi Srinivasan, Ruth E. Ley, Andrew T. Gewirtz. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature, 2015; DOI: 10.1038/nature14232 Lerner A1, Matthias T2. Autoimmun Rev. 2015 Feb 9. pii: S1568-9972(15)00024-5. doi: 10.1016/j.autrev.2015.01.009. [Epub ahead of print]. Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease. Nutrients. 2015 Feb 27;7(3):1565-76. doi: 10.3390/nu7031565. Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity. Hollon J, Puppa EL, Greenwald B, Goldberg E, Guerrerio A, Fasano A. Vazquez-Roque, M.I.; Camilleri, M.; Smyrk, T.; Murray, J.A.; Marietta, E.; O’Neill, J.; Carlson, P.; Lamsam, J.; Janzow, D.; Eckert, D.; et al. A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: Effects on bowel frequency and intestinal function. Gastroenterology 2013, 144, 903–911.e3. doi: 10.1053/j.gastro.2013.01.049.

NEW RELEASES Vojdani A. Detection of IgE, IgG, IgA and IgM antibodies against raw and processed food antigens. Nutr Metab (Lond). 2009 May 12;6:22. doi: 10.1186/1743-7075-6-22. CONFERENCE Oschman, J.L., 2008. Energy Medicine and Longevity. Chapter 27 in Anti-Aging Therapeutics, Volume X, Edited by Klatz, R. and Goldman, R., American Academy of Anti-Aging Medicine, Chicago IL, pp. 211-218.

March 2015


The Free Radical Theory of Aging Matures. Kenneth B. Beckman , Bruce N. Ames, Physiological Reviews Published 1 April 1998 Vol. 78 no. 2, 547-581. Mutagens and Multivitamins, by Megan Scudellari. The Scientist, June 1, 2014: McCann et al. Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging? American Journal of Clinical Nutrition, 2009; DOI: 10.3945/ajcn.2009.27930 Ames et al. Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage. Proceedings of the National Academy of Sciences, 2006; 103 (47): 17589 DOI: 10.1073/pnas.0608757103 Li Wang, Peter L. Bordi, Jennifer A. Fleming, Alison M. Hill, and Penny M. Kris‐etherton. Effect of a Moderate Fat Diet With and Without Avocados on Lipoprotein Particle Number, Size and Subclasses in Overweight and Obese Adults: A Randomized, Controlled Trial. Journal of the American Heart Association, January 2015 DOI: 10.1161/JAHA.114.001355 Sarah A. Johnson, Arturo Figueroa, Negin Navaei, Alexei Wong, Roy Kalfon, Lauren T. Ormsbee, Rafaela G. Feresin, Marcus L. Elam, Shirin Hooshmand, Mark E. Payton, Bahram H. Arjmandi. Daily Blueberry Consumption Improves Blood Pressure and Arterial Stiffness in Postmenopausal Women with Pre- and Stage 1-Hypertension: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Journal of the Academy of Nutrition and Dietetics, 2015; DOI: 10.1016/j.jand.2014.11.001 Markus Juonala, Atte Voipio, Katja Pahkala, Jorma S. A. Viikari, Vera Mikkilä, Mika Kähönen, Nina Hutri-Kähönen, Antti Jula, David Burgner, Matthew A. Sabin, Jukka Marniemi, Britt-Marie Loo, Tomi Laitinen, Eero Jokinen, Leena Taittonen, Costan G. Magnussen, Olli T. Raitakari. Childhood 25-OH Vitamin D Levels and Carotid Intima-Media Thickness in Adulthood: The Cardiovascular Risk in Young Finns Study. The Journal of Clinical Endocrinology & Metabolism, 2015; jc.2014-3944 DOI: 10.1210/jc.2014-3944 NEWS Z. Harcombe, J. S. Baker, S. M. Cooper, B. Davies, N. Sculthorpe, J. J. DiNicolantonio, F. Grace. Evidence from randomised controlled trials did not support the introduction of dietary fat guidelines in 1977 and 1983: a systematic review and meta-analysis. Open Heart, 2015; 2 (1): e000196 DOI: 10.1136/openhrt-2014-000196 Bahl. The evidence base for fat guidelines: a balanced diet. Open Heart, 2015; 2 (1): e000229 DOI: 10.1136/openhrt-2014-000229 Jessie E. Green, Alan G. Brown, Punam Ohri-Vachaspati. Sociodemographic Disparities among Fast-Food Restaurant Customers Who Notice and Use Calorie Menu Labels. Journal of the Academy of Nutrition and Dietetics, 2015; DOI: 10.1016/j.jand.2014.12.004 Felicity L. Bishop, Lucy Yardley, Philip Prescott, Cyrus Cooper, Paul Little, George T. Lewith. Psychological Covariates of Longitudinal Changes in Back-related Disability in Patients Undergoing Acupuncture. The Clinical Journal of Pain, 2015; 31 (3): 254 DOI: 10.1097/AJP.0000000000000108 NEW RELEASES Stanislavov R, Rohdewald P (2014) PACR (Pine Bark Extract, L Arginine, L Citrulline, Rose Hip Extract) Improves Emotional, Physical Health and Sexual Function in Peri-Menopausal Women. J Women’s Health Care 3: 195. doi:10.4172/2167-0420.1000195.

IHCAN CONFERENCES Goodrich Julia K et al. Human genetics shape the gut microbiome. Cell 2014, 159(4): 789-99. DOI: RESEARCH Natalia M. Grindler, Jenifer E. Allsworth, George A. Macones, Kurunthachalam Kannan, Kimberly A. Roehl, Amber R. Cooper. Persistent Organic Pollutants and Early Menopause in U.S. Women. PLOS ONE, 2015; 10 (1): e0116057 DOI: 10.1371/journal.pone.0116057 Nancy E. Avis, Sybil L. Crawford, Gail Greendale, Joyce T. Bromberger, Susan A. Everson-Rose, Ellen B. Gold, Rachel Hess, Hadine Joffe, Howard M. Kravitz, Ping G. Tepper, Rebecca C. Thurston. Duration of Menopausal Vasomotor Symptoms Over the Menopause Transition. JAMA Internal Medicine, 2015; DOI: 10.1001/jamainternmed.2014.8063 Gloria Richard-Davis, JoAnn E. Manson. Vasomotor Symptom Duration in Midlife Women—Research Overturns Dogma. JAMA Internal Medicine, 2015; DOI: 10.1001/jamainternmed.2014.8099 Jerome Sarris, PhD et al. Nutritional medicine as mainstream in psychiatry. The Lancet Psychiatry, January 2015 DOI: 10.1016/S2215-0366(14)00051-0 Sadeq A. Quraishi, Caitlin Mccarthy, Livnat Blum, J. Perren Cobb, and Carlos A. Camargo, Jr. Plasma 25-Hydroxyvitamin D Levels at Initiation of Care and Duration of Mechanical Ventilation in Critically Ill Surgical Patients. Journal of Parenteral and Enteral Nutrition, January 2015 DOI: 10.1177/0148607114566276. Méplan, Heinz Freisling, H.Bas Bueno-de-Mesquita, Sandra Hybsier, Niels-Peter Becker, Magdalena Czuban, Anne Tjønneland, Malene Outzen, Marie-Christine Boutron-Ruault, Antoine Racine, Nadia Bastide, Tilman Kühn, Rudolf Kaaks, Dimitrios Trichopoulos, Antonia Trichopoulou, Pagona Lagiou, Salvatore Panico, Petra H Peeters, Elisabete Weiderpass, Guri Skeie, Engeset Dagrun, Maria-Dolores Chirlaque, Maria-Jose Sánchez, Eva Ardanaz, Ingrid Ljuslinder, Maria Wennberg, Kathryn E Bradbury, Paolo Vineis, Alessio Naccarati, Domenico Palli, Heiner Boeing, Kim Overvad, Miren Dorronsoro, Paula Jakszyn, Amanda J. Cross, Jose Ramón Quirós, Magdalena Stepien, So Yeon Kong, Talita Duarte-Salles, Elio Riboli, John E. Hesketh. Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort. International Journal of Cancer, 2015; 136 (5): 1149 DOI: 10.1002/ijc.29071. Naiane F.B. Alves, Suênia K.P. Porpino, Matheus M.O. Monteiro, Enéas R.M. Gomes, Valdir A. Braga. Coconut oil supplementation and physical exercise improves baroreflex sensitivity and oxidative stress in hypertensive rats. Applied Physiology, Nutrition, and Metabolism, 2015; 1 DOI: 10.1139/apnm-2014-0351 Jj Strain, Alison J Yeates, Edwin Van Wijngaarden, Sally W Thurston, Maria S Mulhern, Emeir M Mcsorley, Gene E Watson, Tanzy M Love, Tristram H Smith, Kelley Yost, Donald Harrington, Conrad F Shamlaye, Juliette Henderson, Gary J Myers, and Philip W Davidson. Prenatal exposure to methyl mercury from fish consumption and polyunsaturated fatty acids: associations with child development at 20 mo of age in an observational study in the Republic of Seychelles. American Journal of Clinical Nutrition, January 2015 DOI: 10.3945/ajcn.114.100503 R. Richardson, M. M. Taylor, S. L. Shalat, T. S. Guillot, W. M. Caudle, M. M. Hossain, T. A. Mathews, S. R. Jones, D. A. Cory-Slechta, G. W. Miller. Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder. The FASEB Journal, 2015; DOI: 10.1096/fj.14-260901

February 2015

International Diabetes Federation. The global burden 2014. Available from: 1. Tinker LF, Bonds DE, Margolis KL, Manson JE, Howard BV, Larson J, Perri MG, Beresford SA, Robinson JG, Rodríguez B, Safford MM, Wenger NK, Stevens VJ, Parker LM; Women’s Health Initiative. Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women: the Women’s Health Initiative randomized controlled dietary modification trial. Arch Intern Med. 2008 Jul 28;168(14):1500-11. doi: 10.1001/archinte.168.14.1500.2. Ajala O, English P, Pinkney J. Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes. Am J Clin Nutr. 2013 Mar;97(3):505-16. doi: 10.3945/ajcn.112.042457.3. Action to Control Cardiovascular Risk in Diabetes Study Group, Gerstein HC, Miller ME, Byington RP, Goff DC Jr, Bigger JT, Buse JB, Cushman WC, Genuth S, Ismail-Beigi F, Grimm RH Jr, Probstfield JL, Simons-Morton DG, Friedewald WT. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008 Jun 12;358(24):2545-59. doi: 10.1056/NEJMoa0802743.4. Feinman RD, Pogozelski WK, Astrup A, Bernstein RK, Fine EJ, Westman EC, Accurso A, Frassetto L, Gower BA, McFarlane SI, Nielsen JV, Krarup T, Saslow L, Roth KS, Vernon MC, Volek JS, Wilshire GB, Dahlqvist A, Sundberg R, Childers A, Morrison K, Manninen AH, Dashti HM, Wood RJ, Wortman J, Worm N. Dietary carbohydrate restriction as the first approach in diabetes management: Critical review and evidence base. Nutrition. 2015 Jan;31(1):1-13. doi: 10.1016/j.nut.2014.06.011.5. Westman EC, Yancy WS Jr, Humphreys M. Dietary treatment of diabetes mellitus in the pre-insulin era (1914-1922). Perspect Biol Med 2006, 49(1):77-83.6. Feinman RD, Volek JS. Carbohydrate restriction as the default treatment for type 2 diabetes and metabolic syndrome. Scand Cardiovasc J 2008, Aug;42(4):256-63. doi: 10.1080/14017430802014838.7. Westman EC, Vernon MC. Has carbohydrate-restriction been forgotten as a treatment for diabetes mellitus? A perspective on the ACCORD study design. Nutr Metab (Lond) 2008 Apr 9;5:10. doi: 10.1186/1743-7075-5-10.

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Research Filip Scheperjans, Velma Aho, Pedro A. B. Pereira, Kaisa Koskinen, Lars Paulin, Eero Pekkonen, Elena Haapaniemi, Seppo Kaakkola, Johanna Eerola-Rautio, Marjatta Pohja, Esko Kinnunen, Kari Murros, Petri Auvinen. Gut microbiota are related to Parkinson’s disease and clinical phenotype. Movement Disorders, 2014; DOI: 10.1002/mds.26069 Aviroop Biswas, Paul I. Oh, Guy E. Faulkner, Ravi R. Bajaj, Michael A. Silver, Marc S. Mitchell, and David A. Alter. Sedentary Time and Its Association With Risk for Disease Incidence, Mortality, and Hospitalization in Adults: A Systematic Review and Meta-analysis. Annals of Internal Medicine, 2015 DOI: 10.7326/M14-1651 Petter Brodin, Vladimir Jojic, Tianxiang Gao, Sanchita Bhattacharya, Cesar J. Lopez Angel, David Furman, Shai Shen-Orr, Cornelia L. Dekker, Gary E. Swan, Atul J. Butte, Holden T. Maecker, Mark M. Davis. Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences. Cell, 2015; 160 (1-2): 37 DOI: 10.1016/j.cell.2014.12.020 Yasuhiko Kizuka, Shinobu Kitazume, Reiko Fujinawa, Takashi Saito, Nobuhisa Iwata, Takaomi C. Saido, Miyako Nakano,Yoshiki Yamaguchi, Yasuhiro Hashimoto, Matthias Staufenbiel, Hiroyuki Hatsuta, Shigeo Murayama, Hiroshi Manya, Tamao Endo, Naoyuki Taniguchi. An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer’s disease. EMBO Molecular Medicine, January 2015 DOI: 10.15252/emmm.201404438 Ulf Ekelund et al. Physical activity and all-cause mortality across levels of overall and abdominal adiposity in European men and women: the European Prospective Investigation into Cancer and Nutrition Study (EPIC). Am J Clin Nutr, January 14, 2015 DOI: 10.3945/ajcn.114.100065 Helen Lambert, Lynda Frassetto, J. Bernadette Moore, David Torgerson, Richard Gannon , Peter Burckhardt and Susan Lanham-New. The effect of supplementation with alkaline potassium salts on bone metabolism: a meta-analysis. Osteoporosis International, January 2015 DOI: 10.1007/s00198-014-3006-9. Emily Ho et al. SUV39H1/H3K9me3 attenuates sulforaphane-induced apoptotic signaling in PC3 prostate cancer cells. Oncogenesis, December 2014 DOI: 10.1038/oncsis.2014.47 News

Ouyang, M. P. Longnecker, S. A. Venners, S. Johnson, S. Korrick, J. Zhang, X. Xu, P. Christian, M.-C. Wang, X. Wang. Preconception serum 1,1,1-trichloro-2,2,bis(p-chlorophenyl)ethane and B-vitamin status: independent and joint effects on women’s reproductive outcomes. American Journal of Clinical Nutrition, 2014; 100 (6): 1470 DOI: 10.3945/ajcn.114.088377
Sona Kang, Linus T. Tsai, Yiming Zhou, Adam Evertts, Su Xu, Michael J. Griffin, Robbyn Issner, Holly J. Whitton, Benjamin A. Garcia, Charles B. Epstein, Tarjei S. Mikkelsen, Evan D. Rosen. Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis. Nature Cell Biology, 2014; 17 (1): 44 DOI: 10.1038/ncb3080

January 2015

News Michael D. Miedema, Faye L. Lopez, Michael J. Blaha, Salim S. Virani, Josef Coresh, Christie M. Ballantyne, Aaron R. Folsom. Eligibility for Statin Therapy According to New Cholesterol Guidelines and Prevalent Use of Medication to Lower Lipid Levels in an Older US Cohort. JAMA Internal Medicine 2014, DOI: 10.1001/jamainternmed.2014.6288 Application of new cholesterol guidelines to a population-based sample. Pencina MJ1, Navar-Boggan AM, D’Agostino RB Sr, Williams K, Neely B, Sniderman AD, Peterson ED N Engl J Med. 2014 Apr 10;370(15):1422-31. doi: 10.1056/NEJMoa1315665 . Stanley Blue, Elizabeth Shove, Chris Carmona, Michael P. Kelly. Theories of practice and public health: understanding (un)healthy practices. Critical Public Health, 2014; 1 DOI: 10.1080/09581596.2014.980396 Page 32, Research update CJ Watson, D Grando, CK Fairley, P Chondros, SM Garland, SP Myers, M Pirotta. The effects of oral garlic on vaginal candida colony counts: a randomised placebo controlled double-blind trial. BJOG: An International Journal of Obstetrics & Gynaecology, 2013; DOI: 10.1111/1471-0528.12518 M.C. Verdenelli, M.M. Coman, C. Cecchini, S. Silvi, C. Orpianesi, A. Cresci. Evaluation of antipathogenic activity and adherence properties of humanLactobacillusstrains for vaginal formulations. Journal of Applied Microbiology, 2014; DOI: 10.1111/jam.12459 Pranab K. Mukherjee, Jyotsna Chandra, Mauricio Retuerto, Masoumeh Sikaroodi, Robert E. Brown, Richard Jurevic, Robert A. Salata, Michael M. Lederman, Patrick M. Gillevet, Mahmoud A. Ghannoum. Oral Mycobiome Analysis of HIV-Infected Patients: Identification of Pichia as an Antagonist of Opportunistic Fungi. PLoS Pathogens, 2014; 10 (3): e1003996 DOI: 10.1371/journal.ppat.1003996 Nat Commun. 2013;4:1342. doi: 10.1038/ncomms2343. Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans. Smeekens SP1, Ng A, Kumar V, Johnson MD, Plantinga TS, van Diemen C, Arts P, Verwiel ET, Gresnigt MS, Fransen K, van Sommeren S, Oosting M, Cheng SC, Joosten LA, Hoischen A, Kullberg BJ, Scott WK, Perfect JR, van der Meer JW, Wijmenga C, Netea MG, Xavier RJ. Link to Free PMC Article Junhua Li et al. An integrated catalog of reference genes in the human gut microbiome. Nature Biotechnology, 2014; 32 (8): 834 DOI: 10.1038/nbt.2942 Benoit Chassaing, Ruth E. Ley, Andrew T. Gewirtz. Intestinal Epithelial Cell Toll-like Receptor 5 Regulates the Intestinal Microbiota to Prevent Low-Grade Inflammation and Metabolic Syndrome in Mice. Gastroenterology, 2014; 147 (6): 1363 DOI: 10.1053/j.gastro.2014.08.033 VA Hodgetts, RK Morris, A Francis, J Gardosi, KM Ismail. Effectiveness of folic acid supplementation in pregnancy on reducing the risk of small-for-gestational age neonates: a population study, systematic review and meta-analysis. BJOG: An International Journal of Obstetrics & Gynaecology, 2014; DOI: 10.1111/1471-0528.13202 Bärbel S Blaum, Jonathan P Hannan, Andrew P Herbert, David Kavanagh, Dušan Uhrín, Thilo Stehle. Structural basis for sialic acid–mediated self-recognition by complement factor H. Nature Chemical Biology, 2014; DOI: 10.1038/nchembio.1696 Mu Chen, Qi Sun, Edward Giovannucci, Dariush Mozaffarian, JoAnn E Manson, Walter C Willett, Frank B Hu. Dairy consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis. BMC Medicine, 2014; 12 (1): 215 DOI: 10.1186/s12916-014-0215-1
Warinner, J. Hendy, C. Speller, E. Cappellini, R. Fischer, C. Trachsel, J. Arneborg, N. Lynnerup, O. E. Craig, D. M. Swallow, A. Fotakis, R. J. Christensen, J. V. Olsen, A. Liebert, N. Montalva, S. Fiddyment, S. Charlton, M. Mackie, A. Canci, A. Bouwman, F. Rühli, M. T. P. Gilbert, M. J. Collins. Direct evidence of milk consumption from ancient human dental calculus. Scientific Reports, 2014; 4: 7104 DOI: 10.1038/srep07104
L. Tarry-Adkins, D. S. Fernandez-Twinn, J.-H. Chen, I. P. Hargreaves, M. S. Martin-Gronert, J. M. McConnell, S. E. Ozanne. Nutritional programming of coenzyme Q: potential for prevention and intervention? The FASEB Journal, 2014; 28 (12): 5398 DOI: 10.1096/fj.14-259473
Honda, Y. Nagai, T. Matsunaga, N. Okamoto, Y. Watanabe, K. Tsuneyama, H. Hayashi, I. Fujii, M. Ikutani, Y. Hirai, A. Muraguchi, K. Takatsu. Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation. Journal of Leukocyte Biology, 2014; 96 (6): 1087 DOI: 10.1189/jlb.3A0114-005RR
Adrian R Martineau, Wai Yee James, Richard L Hooper, Neil C Barnes, David A Jolliffe, Claire L Greiller, Kamrul Islam, David McLaughlin, Angshu Bhowmik, Peter M Timms, Raj K Rajakulasingam, Marion Rowe, Timothy R Venton, Aklak B Choudhury, David E Simcock, Mark Wilks, Amarjeet Degun, Zia Sadique, William R Monteiro, Christopher J Corrigan, Catherine M Hawrylowicz, Christopher J Griffiths. Vitamin D3 supplementation in patients with chronic obstructive pulmonary disease (ViDiCO): a multicentre, double-blind, randomised controlled trial. The Lancet Respiratory Medicine, 2014; DOI: 10.1016/S2213-2600(14)70255-3 Page 25 MEND 1.0 table Bredesen table refs 5. Bredesen DE, John, V. Next generation therapeutics for Alzheimer’s disease. EMBO Mol Med. 2013; 5:795‐798.

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