A full online archive of references

September 2019

The economic case for prevention of population vitamin D deficiency: a modelling study using data from England and Wales. Aguiar et’ al.  European Journal of Clinical Nutrition 2019, Aug 20.

Aguiar, M., Andronis, L., Pallan, M., Högler, W., and Frew, E. (2019). The economic case

Birnbaum, AK, Karanam, A, Marino, SE, et al. Food effect on pharmacokinetics of cannabidiol oral capsules in adult patients with refractory epilepsy. Epilepsia. 2019; 60: 1586– 1592.

Characteristics and patient pathways of Lyme disease patients: a retrospective analysis of hospital episode data in England and Wales (1998-2015) 
Tulloch et alBMC Public Health 2019 
DOI: 10.1186/s12889-019-7245-8

Green R, Lanphear B, Hornung R, et al. Association Between Maternal Fluoride Exposure During Pregnancy and IQ Scores in Offspring in Canada. JAMA Pediatr. Published online August 19, 2019. doi:10.1001/jamapediatrics.2019.1729

Ashley J. Malin, Corina Lesseur, Stefanie A. Busgang, Paul Curtin, Robert O. Wright, Alison P. Sanders. Fluoride exposure and kidney and liver function among adolescents in the United States: NHANES, 2013–2016Environment International, 2019; 105012 DOI: 10.1016/j.envint.2019.105012

Mariosa D, Carreras-Torres R, Martin RM, Johansson M, Brennan P
What can Mendelian randomization tell us about causes of cancer?
Int J Epidemiol, 48(3):816–21. Published 25 July 2019;

Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association. Ann C. Skulas-Ray et al. Ciculation 2019, 19 Aug.

Prevalence and Severity of Sesame Allergy in the United States. Warren CM, Chadha AS, Sicherer SH, Jiang J, Gupta RS. JAMA Netw Open. Published online August 02, 20192(8):e199144. doi:10.1001/jamanetworkopen.2019.9144.

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes. Dequina A. Nicholas et al. Cell Metabolism,

2019, online Aug 1.

Amir Minerbi, Emmanuel Gonzalez, Nicholas J.B. Brereton, Abraham Anjarkouchian, Ken Dewar, Mary-Ann Fitzcharles, Stéphanie Chevalier, Yoram Shir. Altered microbiome composition in individuals with fibromyalgiaPAIN, 2019; 1 DOI: 10.1097/j.pain.0000000000001640.

NEWS extra

Whole genome sequencing revealed new molecular characteristics in multidrug resistant staphylococci recovered from high frequency touched surfaces in London.

Rory Cave et al. Scientific Reports 2019, vol 9, Article number: 9637.

Maija P T Ylilauri, Sari Voutilainen, Eija Lönnroos, Heli E K Virtanen, Tomi-Pekka Tuomainen, Jukka T Salonen, Jyrki K Virtanen, Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study, The American Journal of Clinical Nutrition, , nqz148,

Effect of Montmorency tart cherry juice on cognitive performance in older adults: a randomized controlled trial. Chai SC et al.  Food Funct. 2019 Jul 17;10(7):4423-4431. doi: 10.1039/c9fo00913b.

NEW RELEASES – vitamin D

Worm N. Heilkraft D: How the sun vitamin protects against heart attack, cancer and other lifestyle diseases. systemed Verlag, Lünen. 2010, p12.

LansdowAnaglin, Rebecca ES, et al. Vitamin D deficiency and depression in adults: systematic review and meta-analysis. The British journal of psychiatry, 2013, 202. Jg., Nr. 2, S. 100-107.

Provost SC. Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology (Berl). 1998 Feb;135(4):319-23.

In a study, substitution with vitamin D three times significantly shortened sputum conversion in patients with open lung tuberculosis. Lancet (2011; doi: 10.1016/S0140-6736(10)61889-2)

Reins RV and McDermott  AM: Vitamin D: Implications for Ocular Disease and Therapeutic Potential. Exp Eye Res. 2015 May; 134: 101–110.

BEN BROWN – Fibromyalgia

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  2. Queiroz LP. Worldwide epidemiology of fibromyalgia. Curr Pain Headache Rep. 2013 Aug;17(8):356.
  3. Wolfe F, Walitt B, Perrot S, Rasker JJ, Häuser W. Fibromyalgia diagnosis and biased assessment: Sex, prevalence and bias. PLoS One. 2018 Sep 13;13(9):e0203755.
  4. Wang SM, Han C, Lee SJ, Patkar AA, Masand PS, Pae CU. Fibromyalgia diagnosis:  a review of the past, present and future. Expert Rev Neurother. 2015 Jun;15(6):667-79.
  5. Choy E, Perrot S, Leon T, Kaplan J, Petersel D, Ginovker A, Kramer E. A patient survey of the impact of fibromyalgia and the journey to diagnosis. BMC Health Serv Res. 2010 Apr 26;10:102.
  6. Higgs JB. Fibromyalgia in Primary Care. Prim Care. 2018 Jun;45(2):325-341.
  7. Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Häuser W, Katz RL, Mease PJ, Russell AS, Russell IJ, Walitt B. 2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum. 2016 Dec;46(3):319-329.
  8. Zachrisson O, Regland B, Jahreskog M, Kron M, Gottfries CG. A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale). J Psychosom Res. 2002 Jun;52(6):501-9.
  9. Theoharides TC, Tsilioni I, Arbetman L, Panagiotidou S, Stewart JM, Gleason RM, Russell IJ. Fibromyalgia syndrome in need of effective treatments. J Pharmacol Exp Ther. 2015 Nov;355(2):255-63.
  10. Coskun Benlidayi I. Role of inflammation in the pathogenesis and treatment of  fibromyalgia. Rheumatol Int. 2019 May;39(5):781-791.
  11. Meeus M, Nijs J, Hermans L, Goubert D, Calders P. The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: peripheral and central mechanisms as therapeutic targets? Expert Opin Ther Targets. 2013 Sep;17(9):1081-9.
  12. Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014 Apr 16;311(15):1547-55.
  13. Clauw DJ, Arnold LM, McCarberg BH; FibroCollaborative. The science of fibromyalgia. Mayo Clin Proc. 2011 Sep;86(9):907-11.
  14. Schmidt-Wilcke T, Clauw DJ. Fibromyalgia: from pathophysiology to therapy. Nat Rev Rheumatol. 2011 Jul 19;7(9):518-27.
  15. Häuser W, Ablin J, Fitzcharles MA, Littlejohn G, Luciano JV, Usui C, Walitt B. Fibromyalgia. Nat Rev Dis Primers. 2015 Aug 13;1:15022.
  16. Rahman A, Underwood M, Carnes D. Fibromyalgia. BMJ. 2014 Feb 24;348:g1224.
  17. Sluka KA, Clauw DJ. Neurobiology of fibromyalgia and chronic widespread pain. Neuroscience. 2016 Dec 3;338:114-129.
  18. Theoharides TC, Tsilioni I, Arbetman L, Panagiotidou S, Stewart JM, Gleason RM, Russell IJ. Fibromyalgia syndrome in need of effective treatments. J Pharmacol Exp Ther. 2015 Nov;355(2):255-63.
  19. Macfarlane GJ, Kronisch C, Dean LE, Atzeni F, Häuser W, Fluß E, Choy E, Kosek  E, Amris K, Branco J, Dincer F, Leino-Arjas P, Longley K, McCarthy GM, Makri S, Perrot S, Sarzi-Puttini P, Taylor A, Jones GT. EULAR revised recommendations for the management of fibromyalgia. Ann Rheum Dis. 2017 Feb;76(2):318-328.
  20. Logan, AC. Dietary Modifications and Fibromyalgia. Complementary Health Practice Review, vol. 8, no. 3, Oct. 2003, pp. 234–245
  21. Bjørklund G, Dadar M, Chirumbolo S, Aaseth J. Fibromyalgia and nutrition: Therapeutic possibilities? Biomed Pharmacother. 2018 Jul;103:531-538.
  22. Totsch SK, Waite ME, Sorge RE. Dietary influence on pain via the immune system. Prog Mol Biol Transl Sci. 2015;131:435-69.
  23. Bell RF, Borzan J, Kalso E, Simonnet G. Food, pain, and drugs: does it matter what pain patients eat? Pain. 2012 Oct;153(10):1993-6.
  24. Silva AR, Bernardo A, Costa J, Cardoso A, Santos P, de Mesquita MF, Vaz Patto  J, Moreira P, Silva ML, Padrão P. Dietary interventions in fibromyalgia: a systematic review. Ann Med. 2019;51(sup1):2-14.
  25. Høstmark AT, Lystad E, Vellar OD, Hovi K, Berg JE. Reduced plasma fibrinogen, serum peroxides, lipids, and apolipoproteins after a 3-week vegetarian diet. Plant Foods Hum Nutr. 1993 Jan;43(1):55-61.
  26. Kaartinen K, Lammi K, Hypen M, Nenonen M, Hanninen O, Rauma AL. Vegan diet alleviates fibromyalgia symptoms. Scand J Rheumatol. 2000;29(5):308-13.
  27. Hänninen, Kaartinen K, Rauma AL, Nenonen M, Törrönen R, Häkkinen AS, Adlercreutz H, Laakso J. Antioxidants in vegan diet and rheumatic disorders. Toxicology. 2000 Nov 30;155(1-3):45-53.
  28. Azad KA, Alam MN, Haq SA, Nahar S, Chowdhury MA, Ali SM, Ullah AK. Vegetarian  diet in the treatment of fibromyalgia. Bangladesh Med Res Counc Bull. 2000 Aug;26(2):41-7.
  29. Donaldson MS, Speight N, Loomis S. Fibromyalgia syndrome improved using a mostly raw vegetarian diet: an observational study. BMC Complement Altern Med. 2001;1:7.
  30. Michalsen A, Riegert M, Lüdtke R, Bäcker M, Langhorst J, Schwickert M, Dobos GJ. Mediterranean diet or extended fasting’s influence on changing the intestinal microflora, immunoglobulin A secretion and clinical outcome in patients with rheumatoid arthritis and fibromyalgia: an observational study. BMC Complement Altern Med. 2005 Dec 22;5:22.
  31. Correa-Rodríguez M, Mansouri-Yachou JE, Tapia-Haro RM, Molina F, Rus A, Rueda-Medina B, Aguilar-Ferrandiz ME. Mediterranean Diet, Body Composition, and Activity Associated with Bone Health in Women with Fibromyalgia Syndrome. Nurs Res. 2019 Apr 1. doi: 10.1097/NNR.0000000000000361. [Epub ahead of print]
  32. Costa de Miranda R, Paiva ES, Suter Correia Cadena SM, Brandt AP, Vilela RM. Polyphenol-Rich Foods Alleviate Pain and Ameliorate Quality of Life in Fibromyalgic Women. Int J Vitam Nutr Res. 2017 Mar;87(1-2):66-74.
  33. Rus A, Molina F, Ramos MM, Martínez-Ramírez MJ, Del Moral ML. Extra Virgin Olive Oil Improves Oxidative Stress, Functional Capacity, and Health-Related Psychological Status in Patients With Fibromyalgia: A Preliminary Study. Biol Res Nurs. 2017 Jan;19(1):106-115.
  34. Arranz LI, Rafecas M, Alegre C. Effects of obesity on function and quality of  life in chronic pain conditions. Curr Rheumatol Rep. 2014 Jan;16(1):390.
  35. Timmerman GM, Calfa NA, Stuifbergen AK. Correlates of body mass index in women with fibromyalgia. Orthop Nurs. 2013 Mar-Apr;32(2):113-9.
  36. Aparicio VA, Ortega FB, Carbonell-Baeza A, Camiletti D, Ruiz JR, Delgado-Fernández M. Relationship of weight status with mental and physical health in female fibromyalgia patients. Obes Facts. 2011;4(6):443-8.
  37. Shapiro JR, Anderson DA, Danoff-Burg S. A pilot study of the effects of behavioral weight loss treatment on fibromyalgia symptoms. Journal of psychosomatic research. 2005;59(5):275-82.
  38. Senna MK, Sallam RA, Ashour HS, Elarman M. Effect of weight reduction on the quality of life in obese patients with fibromyalgia syndrome: a randomized controlled trial. Clinical rheumatology. 2012;31(11):1591-7.
  39. Rodrigo L, Blanco I, Bobes J, de Serres FJ. Remarkable prevalence of coeliac disease in patients with irritable bowel syndrome plus fibromyalgia in comparison with those with isolated irritable bowel syndrome: a case-finding study. Arthritis Res Ther. 2013;15(6):R201.
  40. Rodrigo L, Blanco I, Bobes J, de Serres FJ. Clinical impact of a gluten-free diet on health-related quality of life in seven fibromyalgia syndrome patients with associated celiac disease. BMC Gastroenterol. 2013 Nov 9;13:157.
  41. Leone JE, Gray KA, Massie JE, Rossi JM. Celiac disease symptoms in a female collegiate tennis player: a case report. J Athl Train. 2005 Oct-Dec;40(4):365-9.
  42. Taubman B, Mamula P, Sherry DD. Prevalence of asymptomatic celiac disease in children with fibromyalgia: a pilot study. Pediatr Rheumatol Online J. 2011 Jun 13;9:11.
  43. Prada A, Isasi C, Campos J, Otón T, Polo J, García B, Mulero J. Coeliac disease and chronic pain: report of three cases diagnosed in a rheumatology unit, with remission of pain after gluten-free diet [Abstract 115] Rheumatology. 2010;15:i75–i76.
  44. Tovoli F, Giampaolo L, Caio G, Monti M, Piscaglia M, Frisoni M, Bolondi L, Volta U. Fibromyalgia and coeliac disease: a media hype or an emerging clinical problem? Clin Exp Rheumatol. 2013 Nov-Dec;31(6 Suppl 79):S50-2.
  45. Isasi C, Colmenero I, Casco F, Tejerina E, Fernandez N, Serrano-Vela JI, Castro MJ, Villa LF. Fibromyalgia and non-celiac gluten sensitivity: a description with remission of fibromyalgia. Rheumatol Int. 2014 Nov;34(11):1607-12.
  46. Rodrigo L, Blanco I, Bobes J, de Serres FJ. Effect of one year of a gluten-free diet on the clinical evolution of irritable bowel syndrome plus fibromyalgia in patients with associated lymphocytic enteritis: a case-control study. Arthritis Res Ther. 2014 Aug 27;16(4):421.
  47. Slim M, Calandre EP, Garcia-Leiva JM, Rico-Villademoros F, Molina-Barea R, Rodriguez-Lopez CM, Morillas-Arques P. The Effects of a Gluten-free Diet Versus a Hypocaloric Diet Among Patients With Fibromyalgia Experiencing Gluten Sensitivity-like Symptoms: A Pilot, Open-Label Randomized Clinical Trial. J Clin  Gastroenterol. 2017 Jul;51(6):500-507.
  48. Marum AP, Moreira C, Saraiva F, Tomas-Carus P, Sousa-Guerreiro C. A low fermentable oligo-di-mono saccharides and polyols (FODMAP) diet reduced pain and  improved daily life in fibromyalgia patients. Scand J Pain. 2016 Oct;13:166-172
  49. Marum AP, Moreira C, Tomas-Carus P, Saraiva F, Guerreiro CS. A low fermentable oligo-di-mono-saccharides and polyols (FODMAP) diet is a balanced therapy for fibromyalgia with nutritional and symptomatic benefits. Nutr Hosp. 2017 Jun 5;34(3):667-674.
  50. Zanfirescu A, Cristea AN, Nitulescu GM, Velescu BS, Gradinaru D. Chronic Monosodium Glutamate Administration Induced Hyperalgesia in Mice. Nutrients. 2017 Dec 21;10(1).
  51. Smith JD, Terpening CM, Schmidt SO, Gums JG. Relief of fibromyalgia symptoms following discontinuation of dietary excitotoxins. Ann Pharmacother. 2001 Jun;35(6):702-6.
  52. Ciappuccini R, Ansemant T, Maillefert JF, Tavernier C, Ornetti P. Aspartame-induced fibromyalgia, an unusual but curable cause of chronic pain. Clin Exp Rheumatol. 2010 Nov-Dec;28(6 Suppl 63):S131-3.
  53. Holton KF, Taren DL, Thomson CA, Bennett RM, Jones KD. The effect of dietary glutamate on fibromyalgia and irritable bowel symptoms. Clin Exp Rheumatol. 2012 Nov-Dec;30(6 Suppl 74):10-7.
  54. Vellisca MY, Latorre JI. Monosodium glutamate and aspartame in perceived pain in fibromyalgia. Rheumatol Int. 2014 Jul;34(7):1011-3.
  55. Arranz LI, Canela MÁ, Rafecas M. Dietary aspects in fibromyalgia patients: results of a survey on food awareness, allergies, and nutritional supplementation. Rheumatol Int. 2012 Sep;32(9):2615-21.
  56. Haugen M, Kjeldsen-Kragh J, Nordvåg BY, Førre O. Diet and disease symptoms in rheumatic diseases–results of a questionnaire based survey. Clin Rheumatol. 1991 Dec;10(4):401-7.
  57. Puccio FA, Rojas R, Mosquera I, Hernandez A, Mosquera R, Jaua L, Lizarrale M, Cifarrelli D, Reyes R. Food allergy is an important diseases associated to fibromyalgia. Clin Transl Allergy. 2013 Jul 25;3(Suppl 3):P120. doi: 10.1186/2045-7022-3-S3-P120. PubMed Central PMCID: PMC3723944.
  58. Beasley M, Freidin MB, Basu N, Williams FMK, Macfarlane GJ. What is the effect of alcohol consumption on the risk of chronic widespread pain? A Mendelian randomisation study using UK Biobank. Pain. 2019 Feb;160(2):501-507.
  59. Lattanzio SM. Fibromyalgia Syndrome: A Metabolic Approach Grounded in Biochemistry for the Remission of Symptoms. Front Med (Lausanne). 2017 Nov 13;4:198.
  60. Lattanzio SM, Imbesi F. Fibromyalgia Syndrome: A Case Report on Controlled Remission of Symptoms by a Dietary Strategy. Front Med (Lausanne). 2018 Apr 30;5:94.


Tusco R, Jacomin A-C, Jain A, Penman BS, Larsen KB, Johansen T, et al. Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses. Nature Communications 2017, Nov 2;8(1):1264.

Santos RL, Raffatellu M, Bevins CL, et al. Life in the inflamed intestine, Salmonella style. Trends Microbiol. 2009;17(11):498–506. doi:10.1016/j.tim.2009.08.008.

Zha L, Garrett S, Sun J. Salmonella Infection in Chronic Inflammation and Gastrointestinal Cancer. Diseases. 2019;7(1):28. Published 2019 Mar 10. doi:10.3390/diseases7010028.

Padhmanand Sudhakar, Anne-Claire Jacomin, Isabelle Hautefort, Siva Samavedam, Koorosh Fatemian, Eszter Ari, Leila Gul, Amanda Demeter, Emily Jones, Tamas Korcsmaros & Ioannis P. Nezis (2019) Targeted interplay between bacterial pathogens and host autophagy, Autophagy, 15:9, 1620-1633, DOI: 10.1080/15548627.2019.1590519.

Mortreux M et al. A moderate daily dose of resveratrol mitigates muscle deconditioning in a Martian gravity analog. Frontiers in Physiology 2019, 10(899).

Carla Di Mattia, Natalia Battista, Giampiero Sacchetti, Mauro Serafini. Antioxidant Activities in vitro of Water and Liposoluble Extracts Obtained by Different Species of Edible Insects and InvertebratesFrontiers in Nutrition, 2019; 6 DOI: 10.3389/fnut.2019.00106

Ackerman Z. Oron-Herman M. Pappo O. et al (2010) Hepatic effects of rosiglitazone in rats with the metabolic syndrome. Basic Clin. Pharmacol. Toxicol,107, 663–668.

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Davidson RM, Seneff S. (2012)The initial common pathway of inflammation, disease, and sudden death. Entropy 14, 1399–1442. 

Dufault.R. Lukiw WJ. Crider R. et al (2012). A macroepigenetic approach to identify factors responsible for the autism epidemic in the United States. Clin. Epigenet. 4, 6.

Fujita Y, Fujino Y, Onodera M, et al. (2011)A fatal case of acute hydrogen sulfide poisoning caused by hydrogen sulfide: hydroxocobalamin therapy for acute hydrogen sulfide poisoning. J Anal Toxicol;35(2):119-123.

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Nair, R. & Maseeh, A. (2012). Vitamin D: The “sunshine” vitamin. Journal of pharmacology & pharmacotherapeutics3(2), 118–126. doi:10.4103/0976-500X.95506

Jain R. Singh A. Mittal M. & Talukdar,B. (2015). Vitamin B12 Deficiency in Children: A Treatable Cause of Neurodevelopmental Delay. Journal of Child Neurology30(5), 641–643.

James S. Melnyk S. (2010) A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers of children with autism. Am. J. Med. Genet. B Neuropsychiatr. Genet.153B, 1209–1220. 

James S. Melnyk S. Jernigan S. (2006) Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. Am. J. Med. Genet. B 141B, 947–956. 

Kane E (2017) Life on the membrane. Conference presentation at the Neurolipid conference 18.11.2017 Las Vegas.

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Lee S, Park JM, Jeong M, et al.(2016) Korean red ginseng ameliorated experimental pancreatitis through the inhibition of hydrogen sulfide in mice. Pancreatology;16(3):326-336.

Ben Lynch (2017): Pathway planner v5.

Mahboubi M. (2015). Rosa damascena as holy ancient herb with novel applications. Journal of traditional and complementary medicine6(1), 10–16. doi:10.1016/j.jtcme.2015.09.005.

Nair R, & Maseeh A. (2012). Vitamin D: The “sunshine” vitamin. Journal of pharmacology & pharmacotherapeutics3(2), 118–126. doi:10.4103/0976-500X.95506

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Sabol, Jenny & Wei, Wei & Lopez-Hoyos, Marcos & Seo, Youjin & Andaya, Armann & A. Leary, Julie. (2014). Heparan Sulphate Differences in Rheumatoid Arthritis versus Healthy Sera. Matrix Biology. 40. 10.1016/j.matbio.2014.08.016.

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Schultz, S.T.; Klonoff-Cohen, H.S.; Wingard, et al (2008) Acetaminophen (paracetamol) use, measles-mumps-rubella vaccination, and autistic disorder: The results of a parent survey. Autism 12, 293–307. 

Samsel & Seneff (2013) Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases†

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Greg Nigh
SIBO as an adaptation: a proposed role for hydrogen sulfide:  Posted January 8, 2019.


Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes.

Erick Riquelme et al. Cell 2019, August 8, Volume 178, Issue 4.

Fellows Maxwell K, Wahls T, Browne RW, Rubenstein L, Bisht B, Chenard CA, et al. (2019) Lipid profile is associated with decreased fatigue in individuals with progressive multiple sclerosis following a diet-based intervention: Results from a pilot study. PLoS ONE 14(6): e0218075.

August 2019


Van Ende, Wijnants, and Van Dijck, “Sugar Sensing and Signaling in Candida Albicans and Candida Glabrata.” Front. Microbiol 2019., 30 January.


 Millstone E and Dawson E. EFSA’s toxicological assessment of aspartame: was it even-handedly trying to identify possible unreliable positives and unreliable negatives?

Archives of Public Health 2019, 77:34. Open Access.

Arturo Casadevall, Dimitrios P. Kontoyiannis, Vincent Robert. On the Emergence of Candida auris: Climate Change, Azoles, Swamps, and BirdsmBio, 2019; 10 (4) DOI: 10.1128/mBio.01397-19

Emerging Fungal Pathogen Candida auris Evades Neutrophil Attack.

Chad J. Johnson et al. mBio 2018, August. DOI: 10.1128/mBio.01403-18.

Panagioti Maria et al. Prevalence, severity, and nature of preventable patient harm across medical care settings: systematic review and meta-analysis. BMJ 2019; 366 :l4185.

New drugs: where did we go wrong and what can we do better? The BMJDOI: 10.1136/bmj.l4340.

Angela Genoni et al. Long-term Paleolithic diet is associated with lower resistant starch intake, different gut microbiota composition and increased serum TMAO concentrationsEuropean Journal of Nutrition, 2019; DOI: 10.1007/s00394-019-02036-y.

Charline Quiclet et al. Pancreatic adipocytes mediate hypersecretion of insulin in diabetes-susceptible miceMetabolism, 2019; 97: 9 DOI: 10.1016/j.metabol.2019.05.005.


Does Irritable Bowel Syndrome Exist? Identifiable and Treatable Causes of Associated Symptoms Suggest It May Not”. Gastrointest. Disord. 20191(3), 314-340;


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  2. Quigley EMM. The Spectrum of Small Intestinal Bacterial Overgrowth (SIBO). Curr Gastroenterol Rep. 2019 Jan 15;21(1):3.
  3. Aziz I, Törnblom H, Simrén M. Small intestinal bacterial overgrowth as a cause for irritable bowel syndrome: guilty or not guilty? Curr Opin Gastroenterol. 2017 May;33(3):196-202.
  4. Rezaie A, Buresi M, Lembo A, Lin H, McCallum R, Rao S, Schmulson M, Valdovinos M, Zakko S, Pimentel M. Hydrogen and Methane-Based Breath Testing in Gastrointestinal Disorders: The North American Consensus. Am J Gastroenterol. 2017 May;112(5):775-784.
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Extra stories:

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. Nature Genetics, 5: 230–6 (2019).

Ma Hao, Li Xiang, Sun Dianjianyi, Zhou Tao, LeySylvia H, Gustat Jeanette et al. Association of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK Biobank BMJ 2019; 365 :l1628.


Eran Blacher et al. Potential roles of gut microbiome and metabolites in modulating ALS in miceNature, 2019 DOI: 10.1038/s41586-019-1443-5.

 de la Rubia JE et al. Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study. Amyotroph Lateral Scler Frontotemporal Degener. 2019 Feb;20(1-2):115-122. Epub 2019 Jan 22.  

Diana Matheoud et al. Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− miceNature 2019, July 17. DOI: 10.1038/s41586-019-1405-y.

J Psychiatry Neurosci 2019, Jul 1;44(4):269-276. Randomized controlled trial of a gluten-free diet in patients with schizophrenia positive for antigliadin antibodies (AGA IgG): a pilot feasibility study. Kelly DL et al.

Veronika L Tchesnokova et al. Pandemic uropathogenic fluoroquinolone-resistant Escherichia coli have enhanced ability to persist in the gut and cause bacteriuria in healthy women, Clinical Infectious Diseases 2019, July 4, ciz547,

Claire Buchta Rosean et al. Pre-existing commensal dysbiosis is a host-intrinsic regulator of tissue inflammation and tumour cell dissemination in hormone receptor-positive breast cancerCancer Research 2019, July, canres.3464.2018 DOI: 10.1158/0008-5472.CAN-18-3464.

Nat Med. 2019 Jul;25(7):1164-1174. doi: 10.1038/s41591-019-0461-z. Epub 2019 Jun 24. Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy. Abdel-Gadir A et al.

(Also see Curr Opin Immunol. 2019 Jul 11;60:141-147. doi: 10.1016/j.coi.2019.06.001. Regulation of oral immune tolerance by the microbiome in food allergy. Stephen-Victor E, Chatila TA.)


Karin Müller et al. ‘Poly(ADP ribose) links the DNA damage response and biomineralization.’ Cell Reports (2019). DOI: 10.1016/j.celrep.2019.05.038.

Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms. Kunio Kawanishi, Chirag Dhar, Raymond Do, Nissi Varki, Philip L. S. M.Gordts, Ajit Varki

Proceedings of the National Academy of Sciences Jul 2019, 201902902, DOI:10.1073/pnas.1902902116.

Santosh Dhakal et al. Amish (Rural) vs. non-Amish (Urban) Infant Faecal Microbiotas Are Highly Diverse and Their Transplantation Lead to Differences in Mucosal Immune Maturation in a Humanized Germfree Piglet ModelFrontiers in Immunology, 2019; 10 DOI: 10.3389/fimmu.2019.01509.

Clara Depommier et al. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory studyNature Medicine, 2019; DOI: 10.1038/s41591-019-0495-2.

Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies. Kequan Zhou.  J Funct Foods 2017, Jun; 33: 194–201. Published online 2017 Mar 29. doi: 10.1016/j.jff.2017.03.045.

Neuron, Kim and Kwon et al.: “Transneuronal Propagation of Pathologic a-Synuclein from the Gut to the Brain Models Parkinson’s Disease”

Rían W. Manville, Geoffrey W. Abbott. Cilantro leaf harbors a potent potassium channel–activating anticonvulsantThe FASEB Journal, 2019; fj.201900485R DOI: 10.1096/fj.201900485R.

Obón-Santacana, Romaguera et al. Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study)Nutrients, 2019; 11 (6): 1406 DOI: 10.3390/nu11061406

July 2019


Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis. Brandon L. Jutras et al. PNAS 2019,  first published June 17:

Pre-existing commensal dysbiosis is a host-intrinsic regulator of tissue inflammation and tumor cell dissemination in hormone receptor-positive breast cancer

Claire Buchta Rosean, Raegan R Bostic, Joshua C. M. Ferey, Tzu-Yu Feng, Francesca NAzar, Kenneth S Tung, Mikhail G Dozmorov, Ekaterina Smirnova, Paula D. Bos and Melanie R Rutkowski

Cancer Res, May 7, 2019 DOI: 10.1158/0008-5472.CAN-18-3464.

Schwabl P et al (2018), Assessment of microplastic concentrations in human stool – Preliminary results of a prospective study, Presented at UEG Week 2018 Vienna, October 24, 2018. 
Liang Lu, Zhiqin Wan, Ting Luo, Zhengwei Fu, Yuanxiang Jin. Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice,

Science of The Total Environment, Volumes 631–632, 2018, Pages 449-458,

Role of vitamin D supplementation for primary prevention of cancer: Meta-analysis of randomized controlled trials. Varun Samji, Tarek Haykal, Yazan Zayed, Inderdeep Gakhal, Vijay Veerapaneni, Michelle Obeid, Babikir Kheiri, Sunil Badami, Ghassan Bachuwa, and Rizwan Danish. Journal of Clinical Oncology 2019 37:15_suppl, 1534-1534.

M Kyla Shea, Stephen B Kritchevsky, Richard F Loeser, Sarah L Booth. Vitamin K Status and Mobility Limitation and Disability in Older Adults: The Health, Aging, and Body Composition StudyThe Journals of Gerontology: Series A, 2019; DOI: 10.1093/gerona/glz108.

Perceptions of Constipation Among the General Public and People With Constipation Differ Strikingly From Those of General and Specialist Doctors and the Rome IV Criteria. Dimidi, Eirini PhD1; Cox, Camilla MSc1; Grant, Robert MSc2; Scott, S. Mark PhD3; Whelan, Kevin PhD. American Journal of Gastroenterology, June 4, 2019,

doi: 10.14309/ajg.0000000000000267.

Heini Natri, Angela R. Garcia, Kenneth H. Buetow, Benjamin C. Trumble, Melissa A. Wilson. The Pregnancy Pickle: Evolved Immune Compensation Due to Pregnancy Underlies Sex Differences in Human DiseasesTrends in Genetics, 2019; 35 (7): 478 DOI: 10.1016/j.tig.2019.04.008.


Terry Wahls quote: The Seventy Percent Solution, Terry L. Wahls, MD. J Gen Intern Med 26(10):1215–6. DOI: 10.1007/s11606-010-1631-3.


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Pietro KJ, Jensen AM, Schumacher JR, Anderson JW. Vitamin B12 intake correlated to physical and mental improvements in multiple sclerosis specific quality of life. Int J Adv Nutr Health Sci. 2014;2:98-108.


Developing the evidence for kinesiology-style manual muscle testing: A series of diagnostic test accuracy studies. Anne M. Jensen, Richard Stevens , Amanda Burls. Australasian Integrative Medicine Association Conference Abstracts, Sydney, Australia/ Advances in Integrative Medicine 2014, 1 (3): 158.  

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Daily Sampling Reveals Personalized Diet-Microbiome Associations in Humans

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Daniel J Blum, Emmanuel During, Fiona Barwick, Polina Davidenko, Jamie M Zeitzer. 0009 Restless Leg Syndrome: Does It Start With A Gut Feeling? Sleep, 2019; 42 (Supplement_1): A4 DOI: 10.1093/sleep/zsz067.008.

High sensitivity and interindividual variability in the response of the human circadian system to evening light. Andrew J. K. Phillips, Parisa Vidafar, Angus C. Burns, Elise M. McGlashan, Clare Anderson, Shantha M. W. Rajaratnam, Steven W. Lockley, Sean W.Cain. Proceedings of the National Academy of Sciences Jun 2019, 116 (24) 12019-12024; DOI:10.1073/pnas.1901824116.

Kelsey E. McLimans, Bridget E Clark, Alexandra Plagman, Colleen Pappas, Brandon Klinedinst, Vellareddy Anantharam, Anumantha Kanthasamy, Auriel A Willette. Is CSF SOD1 a Biomarker of Tau but not Amyloid Induced Neurodegeneration in Alzheimer’s Disease? Antioxidants & Redox Signaling, 2019; DOI: 10.1089/ars.2019.7762.

Joint Analysis of Metabolite Markers of Fish Intake and Persistent Organic Pollutants in Relation to Type 2 Diabetes Risk in Swedish Adults.

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Lim SH, Methe BA et al. Invasive non-typhoidal Salmonella in sickle cell disease in Africa: is increased permeability the missing link? J Transl Med 2018; 16: 239-46.

June 2019


Butyrate, a metabolite of intestinal bacteria, enhances sleep. Éva Szentirmai et al.

Scientific Reports 2019, 9: 7035, Published May 7.


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Blood test

A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

  1. Esfandyarpour, A. Kashi, M. Nemat-Gorgani, J. Wilhelmy, and R. W. Davis

PNAS first published April 29, 2019


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And theoretical background from:
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Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis        Trovato A, Siracusa R, Di Paola R, Scuto M, Ontario ML, Bua O, Di Mauro P, Toscano MA, Petralia CC, Maiolino L, Serra A, Cuzzocrea S, Calabrese V.. Immun Ageing. 13:23. doi: 10.1186/s12979-016-0078-8. Jul 9 2016.

Neurology, April 23, 2019; 92 (17). Reproductive period and risk of dementia in a diverse cohort of health care members. Paola Gilsanz et al. DOI:

Dietary intake and age at natural menopause: results from the UK Women’s Cohort Study. Yashvee Dunneram, Darren C Greenwood, Victoria J Burley and Janet E Cade.

Journal of Epidemiology and Community Health, 30 April 2018, doi: 10.1136/jech-2017-209887.

Gail A. Greendale, et al. Changes in body composition and weight during the menopause transitionJCI Insight, 2019; 4 (5) DOI: 10.1172/jci.insight.124865.

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Comparison of the Vaginal Microbiomes of Premenopausal and Postmenopausal Women. Karol Gliniewicz et al.

Microb Ecol. 2013 Apr;65(3):773-80. doi: 10.1007/s00248-012-0154-3. Epub 2012 Dec 19. The restoration of the vaginal microbiota after treatment for bacterial vaginosis with metronidazole or probiotics.

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Beibei Yang, Jinbao Wei, Peijun Ju, Jinghong Chen. Effects of regulating intestinal microbiota on anxiety symptoms: A systematic reviewGeneral Psychiatry, 2019; 32: e100056 DOI: 10. 1136/gpsych-2019-100056.

Anna M. Wang, Subechhya Pradhan, Jennifer M. Coughlin, Aditi Trivedi, Samantha L. DuBois, Jeffrey L. Crawford, Thomas W. Sedlak, Fredrick C. Nucifora, Gerald Nestadt, Leslie G. Nucifora, David J. Schretlen, Akira Sawa, Peter B. Barker. Assessing Brain Metabolism With 7-T Proton Magnetic Resonance Spectroscopy in Patients With First-Episode Psychosis. JAMA Psychiatry, 2019; 76 (3): 314 DOI: 10.1001/jamapsychiatry.2018.3637

Thomas W. Sedlak, Bindu D. Paul, Gregory M. Parker, Lynda D. Hester, Adele M. Snowman, Yu Taniguchi, Atsushi Kamiya, Solomon H. Snyder, Akira Sawa. The glutathione cycle shapes synaptic glutamate activity. Proceedings of the National Academy of Sciences, 2019; 116 (7): 2701 DOI: 10.1073/pnas.1817885116

Thomas W. Sedlak, Leslie G. Nucifora, Minori Koga, Lindsay S. Shaffer, Cecilia Higgs, Teppei Tanaka, Anna M. Wang, Jennifer M. Coughlin, Peter B. Barker, Jed W. Fahey, Akira Sawa. Sulforaphane Augments Glutathione and Influences Brain Metabolites in Human Subjects: A Clinical Pilot Study. Molecular Neuropsychiatry, 2017; 3 (4): 214 DOI: 10.1159/000487639

Changwei Li, Jiang He, Shengxu Li, Wei Chen, Lydia Bazzano, Xiao Sun, Luqi Shen, Lirong Liang, Ye Shen, Xiaoying Gu, Tanika N Kelly. Novel Metabolites Are Associated With Augmentation Index and Pulse Wave Velocity: Findings From the Bogalusa Heart StudyAmerican Journal of Hypertension, 2019; DOI: 10.1093/ajh/hpz046

‘Training for a first-time marathon reverses vascular ageing’ presented during the Young Investigator Award session on Friday 3 May at EuroCMR 2019.

Fuehrer D, Fennessy C, Reese RJ. 2014. Runners With More Training Miles Finish Marathons Faster. Runners World. Available online at:

Jones S, D’Silva A, Bhuva A, et al. Improved Exercise-Related Skeletal Muscle Oxygen Consumption Following Uptake of Endurance Training Measured Using Near-Infrared Spectroscopy. Front Physiol. 2017;8:1018. doi: 10.3389/fphys.2017.01018.

Epigenomics. 2019 Feb;11(3):349-362. doi: 10.2217/epi-2018-0081. Epub 2019 Jan 23.

Role of histone acetylation in gastric cancer: implications of dietetic compounds and clinical perspectives.

Calcagno DQ et al.

Cynthia Larbey, Susan M. Mentzer, Bertrand Ligouis, Sarah Wurz, Martin K. Jones. Cooked starchy food in hearths ca. 120 kya and 65 kya (MIS 5e and MIS 4) from Klasies River Cave, South AfricaJournal of Human Evolution, 2019; 131: 210 DOI: 10.1016/j.jhevol.2019.03.015.

Ziad Al Nabhani, Sophie Dulauroy, Rute Marques, Clara Cousu, Shahed Al Bounny, François Déjardin, Tim Sparwasser, Marion Bérard, Nadine Cerf-Bensussan, Gérard Eberl. A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the AdultImmunity, 2019; DOI: 10.1016/j.immuni.2019.02.014

Multipotent fetal-derived Cdx2 cells from placenta regenerate the heart. Sangeetha Vadakke-Madathil, Gina LaRocca, Koen Raedschelders, JesseYoon, Sarah J. Parker, Joseph Tripodi, Vesna Najfeld, Jennifer E. Van Eyk, Hina W. Chaudhry

Proceedings of the National Academy of Sciences, May 2019, 201811827; DOI:10.1073/pnas.1811827116.

Tamia A. Harris, Sureka Gattu, Daniel C. Propheter, Zheng Kuang, Shai Bel, Kelly A. Ruhn, Andrew L. Chara, Marshall Edwards, Chenlu Zhang, Jay-Hyun Jo, Prithvi Raj, Christos C. Zouboulis, Heidi H. Kong, Julia A. Segre, Lora V. Hooper. Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the SkinCell Host & Microbe, 2019; DOI: 10.1016/j.chom.2019.04.004.

Desai T, Roberts M, Bottom L. Effects of Montmorency tart cherry supplementation on cardio-metabolic markers in metabolic syndrome participants: a pilot study. Journal of Functional Foods. 2019; 57: 286-298.

IN PRACTICE – Thalia Pellegrini

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 Zhang LZhang YJChen JHuang XLFang GSYang LJDuan YWang J. The association of HLA-B27 and Klebsiella pneumoniae in ankylosing spondylitis: A systematic review .Microb Pathog. 2018 Apr;117:49-54

The relationship between Klebsiella infection and ankylosing spondylitis Baillière’s Clinical Rheumatology Volume 3, Issue 2, August 1989, Pages 321-338

May 2019


“Nutritional epidemiology is a scandal. It should just go to the waste bin”:

John Ioannidis second quote is here: Report by Sam Bloch.

Why Most Published Research Findings Are False. John P. A. Ioannidis. PLoS Med. 2005 Aug; 2(8): e124. doi: 10.1371/journal.pmed.0020124.

Ng K et al. Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial. JAMA. 2019 Apr 9;321(14):1370-1379. doi: 10.1001/jama.2019.2402.



Hu XY et al. Andrographis paniculata (Chuān Xīn Lián) for symptomatic relief of acute respiratory tract infections in adults and children: A systematic review and meta-analysis. PLoS One. 2017 Aug 4;12(8):e0181780. doi: 10.1371/journal.pone.0181780.

Leveraging Human Microbiome Features to Diagnose and Stratify Children with Irritable Bowel Syndrome. Journal of Molecular Diagnostics 2019, in press.

Emily B. Hollister et al. doi:

Louise Saul, Iris Mair, Alasdair Ivens, Pamela Brown, Kay Samuel, John D. M. Campbell, Daniel Y. Soong, Nadine Kamenjarin, Richard J. Mellanby. 1,25-Dihydroxyvitamin D3 Restrains CD4 T Cell Priming Ability of CD11c Dendritic Cells by Upregulating Expression of CD31Frontiers in Immunology, 2019; 10 DOI: 10.3389/fimmu.2019.00600


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Joe Pizzorno: “Mitochondria – Fundamental to Life and Health”. Integr Med (Encinitas). 2014 Apr; 13(2): 8–15.

  1. Wesselink et al. Feeding mitochondria: Potential role of nutritional components to improve critical illness convalescence. Clinical Nutrition 2018, Aug 31. pii: S0261-5614(18)32426-9. doi: 10.1016/j.clnu.2018.08.032.

Genes (Basel). 2018 Jan 9; 9(1). pii: E22. doi: 10.3390/genes9010022.

The Aging Mitochondria. Theurey PPizzo P.

Elsa Sanchez-Lopez et al. Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 ProductionCell Metabolism, April 11, 2019; DOI: 10.1016/j.cmet.2019.03.011/.

Ale-Agha N, Goy C, Jakobs P, Spyridopoulos I, Gonnissen S, Dyballa-Rukes N, et al. (2018) CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system–New mode of action for caffeine. PLoS Biol 16(6): e2004408.

Nasca C et al. Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):8627-8632. doi: 10.1073/pnas.1801609115. Epub 2018 Jul 30. Acetyl-l-carnitine deficiency in patients with major depressive disorder.


  1. Mohr D, Bowry VW, Stocker R. Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta. 1992 Jun 26;1126(3):247-54.
  2. Ross D et al. NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms. Chem Biol Interact. 2000 Dec 1;129(1-2):77-97.
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‘Game-changing’ study may open door to new cancer therapies’: Jamie Morton, NZ Herald, Nov 21, 2018:

Martina Bajzikova et al. Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells. Cell Metabolism, Volume 29, Issue 2, 5 February 2019, Pages 399-416.e10. doi:


Vitamin D and magnesium

  1. Genetics of hereditary disorders of magnesium homeostasis. Schlingmann, Karl P, Konrad, Martin and Seyberth, Hannsjorg W. 1, 2004, Pediatric Nephrology, Vol. 19, pp. 13-25.
  2. What We Eat In America, NHANES 2005-2006, Usual Nutrient Intakes from Food and Water Compared to 1997 Dietary Reference Intakes for Vitamin D, Calcium, Phosphorus, and Magnesium. Moshfegh, A, et al. s.l. : U.S. Department of Agriculture, Agricultural Research Service, 2009.
  3. Short-term magnesium deficiency downregulates telomerase, upregulates neutral sphingomyelinase and induces oxidative DNA damage in cardiovascular tissues: relevance to atherogenesis, cardiovascular diseases and aging. Shah, N.C, et al. 3, s.l. : International Journal of Clinical and Experimental Medicine, Vol. 7, pp. 497-514.
  4. Magnesium in Prevention and Therapy. Grober, Uwe, Schmidt, Joachim and Kisters, Klaus. 9, s.l. : Nutrients, Vol. 7, pp. 8199-8226.
  5. Vitamin D: The “sunshine” vitamin. Nair, Rathish and Maseeh, Arun. 2, s.l. : Journal of Pharmacology & Pharmacotherapeutics, 2012, Vol. 3, pp. 118-126.
  6. Genetics of Type 2 Diabetes – Pitfalls and Possibilities. Prasad, Rashmi B and Groop, Leif. 1, s.l. : Genes, 2015, Vol. 6, pp. 87-123.
  7. Treatment of hypovitaminosis D in infants and toddlers. Gordon, CM, et al. s.l. : Journal of Clinical Endocrinology Metabolism, 2008, Vol. 93, pp. 2716-2721.
  8. Fracture prevention with vitamin D supplementation: A meta-analysis of randomized controlled trials. Bischoff-Ferrari, HA, et al. s.l. : JAMA, 2005, Vol. 293, pp. 2257-2264.
  9. Vitamin D and calcium intakes and breast cancer risk in pre- and postmenopausal women. Anderson, LN, et al. s.l. : American Journal of Clinical Nutrition, 2010, Vol. 91, pp. 1699-1707.
  10. Vitamin D deficiency and risk of cardiovascular disease. Wang, TJ and Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, et al. s.l. : Circulation, 2008, Vol. 117, pp. 503-511.
  11. Novel CYP27B1 gene mutations in patients with vitamin D-dependent rickets type 1A. Demir, Korcan, et al. 7, s.l. : PLoS One, Vol. 10.
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  16. Oral magnesium supplementation in children with cystic fibrosis improves clinical and functional variables: a double-blind, randomized, placebo-controlled crossover trial. Gontijo-Amaral, Clesio, Guimaraes, Elizabet V and Camargos, Paulo. 1, s.l. : The American Journal of Clinical Nutrition, 2012, Vol. 96, pp. 50-56.
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Ramagopalan SV et al. A ChIP-seq-defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution. Genome Res 2010, 20:1352-60.  doi:10.1101/gr.107920.110.

Qi Dai, Xiangzhu Zhu, JoAnn E Manson, Yiqing Song, Xingnan Li, Adrian A Franke, Rebecca B Costello, Andrea Rosanoff, Hui Nian, Lei Fan, Harvey Murff, Reid M Ness, Douglas L Seidner, Chang Yu, Martha J Shrubsole. Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trialThe American Journal of Clinical Nutrition, 2018; 108 (6): 1249 DOI: 10.1093/ajcn/nqy274

Wang, et al. Gut microbiota have blood types as human. Science Bulletin. Volume 63, Issue 20, 30 October 2018, Pages 1311-1313.


Metabolic health

A dataset quantifying polypharmacy in the United States. Katie J. Quinn and Nigam H. Shah. Sci Data. 2017; 4: 170167. doi: 10.1038/sdata.2017.167

Long-term conditions and multi-morbidity. The Kings Fund:

The prevalence and determinants of polypharmacy at age 69: a British birth cohort study. Mark James Rawle et al. BMC Geriatr 2018; 18: 118. doi: 10.1186/s12877-018-0795-2

Prevalence of Optimal Metabolic Health in American Adults: National Health and Nutrition Examination Survey 2009-2016. Araújo J, Cai J, Stevens J. Metab Syndr Relat Disord. 2019 Feb;17(1):46-52. doi: 10.1089/met.2018.0105.

Brain health

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  4. ‘Metabolism of alpha-linolenic acid’ by Dr. Diane H. Morris, Flax Council,
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  6. Smith, David. (2017). Two nutrients are better than one: B-vitamins and omega-3 fatty acids in the prevention of dementia. Journal of Nutrition & Intermediary Metabolism. 8. 66. 10.1016/j.jnim.2017.04.018.

Alice L. Chen, Kenneth M. Lum, Pablo Lara-Gonzalez, Daisuke Ogasawara, Armand B Cognetta, Alan To, William H. Parsons, Gabriel M. Simon, Arshad Desai, Michael Petrascheck, Liron Bar-Peled, Benjamin F. Cravatt. Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespanNature Chemical Biology, 2019; DOI: 10.1038/s41589-019-0243-4.

Courtney R Chang, Monique E Francois, Jonathan P Little. Restricting carbohydrates at breakfast is sufficient to reduce 24-hour exposure to postprandial hyperglycemia and improve glycemic variabilityThe American Journal of Clinical Nutrition, 2019; DOI: 10.1093/ajcn/nqy261.

Adam Schaffner et al. Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotectionCell Research, 2019; 29 (4): 313 DOI: 10.1038/s41422-019-0153-8

Ng K et al. Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial. JAMA. 2019 Apr 9;321(14):1370-1379. doi: 10.1001/jama.2019.2402.

In Focus - Medicinal Mushrooms May 2019

Digestion feature:

  1. The Global Fungal Red List Initiative (access: 29.03.2019)
  2. Lu L et al. PCR-based sensitive detection of medicinal fungi Hericium species from ribosomal internal transcribed spacer (ITS) sequences. Biol Pharm Bull. 2002 Aug;25(8):975-80.
  3. Wang M et al. Hericium erinaceus (Yamabushitake): a unique resource for developing functional foods and medicines. Food Funct. 2014 Dec;5(12):3055-64.
  4. Shang XD et al. In vitro anti-Helicobacter pylori effects of medicinal mushroom extracts, with special emphasis on the Lion’s Mane mushroom, Hericium erinaceus (higher Basidiomycetes). Int J Med Mushrooms. 2013;15(2):165-74.
  5. Liu JH et al. Anti-Helicobacter pylori activity of bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2015 Sep 10. pii: S0378-8741(15)30130-6. doi: 10.1016/j.jep.2015.09.004. [Epub ahead of print]
  6. Wang M et al. A polysaccharide from cultured mycelium of Hericium erinaceus and its anti-chronic atrophic gastritis activity. Int J Biol Macromol. 2015 Nov;81:656-61. doi: 10.1016/j.ijbiomac.2015.08.043. Epub 2015 Aug 24.
  7. Wong JY et al. Gastroprotective Effects of Lion’s Mane Mushroom Hericium erinaceus (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats. Evid Based Complement Alternat Med. 2013;2013:492976.
  8. Wang M et al. A unique polysaccharide purified from Hericium erinaceus mycelium prevents oxidative stress induced H2O2 in human gastric mucosa cell. PloS One. 2017 Jul 24;12(7):e0181546. doi: 10.1371/journal.pone.0181546. eCollection 2017.
  9. Chen DL et al. Extracts from Hericium erinaceus relieve inflammatory bowel disease by regulating immunity and gut microbiota. Oncotarget. 2017;8(49):85838-57.
  10. Wang D. et al. A polysaccharide from cultured mycelium of Hericium erinaceus relieves ulcerative colitis by counteracting oxidative stress and improving mitochondrial function. Int J Biol Macromol. 2019 Mar 15;125:572-579. doi: 10. 1016/j.ijbiomac.2018.12.092. Epub 2018 Dec 10.

Sport feature:

1 Cordyceps Industry in China, Mycology An International Journal on fungal Biology

ISSN: 2150-1203 (Print) 2150-1211 (Online) Journal homepage:

 3 Life Sci. 2004 Dec 10;76(4):385-95. Pharmacological basis of ‘Yin-nourishing’ and ‘Yang-invigorating’ actions of Cordyceps, a Chinese tonifying herb.

Siu KM1, Mak DH, Chiu PY, Poon MK, Du Y, Ko KM.

4 Cordyceps can increase the ATP stores in the liver J Altern Complement Med. 2001 Jun;7(3):231-40)

5 Koh JH. Antifatigue and antistress effect of the hot-water fraction from mycelia of Cordyceps sinensis. Biol Pharm Bull. 2003 May;26(5):691-4.


J Diet Suppl. Author manuscript; available in PMC 2018 Jan 13.

Published before final editing as: J Diet Suppl. : 1–13. Published online 2016 Jul 13. doi:  10.1080/19390211.2016.1203386 Cordyceps militaris improves tolerance to high intensity exercise after acute and chronic supplementation. Katie R. Hirsch,1 Abbie E. Smith-Ryan,1,2 Erica J. Roelofs,1,3 Eric T. Trexler,1,2 and Meredith G. Mock1

7 Nicodemus K, Hagan R, Zhu J, Baker C. Supplementation with Cordyceps Cs-4 fermentation product promotes fat metabolism during prolonged exercise. Medicine and science in sports and exercise. 2001;33:164.

Neurodegenerative feature:

Cohen N1, Cohen J1, Asatiani MD2, Varshney VK3, Yu HT4, Yang YC4, Li YH4, Mau JL5, Wasser SP6.

Chemical composition and nutritional and medicinal value of fruit bodies and submerged cultured mycelia of culinary-medicinal higher Basidiomycetes mushrooms. Int J Med Mushrooms. 2014;16(3):273-91.

Chin J H, Vora N,The global burden of neurologic diseases (2012) Int J Med Mushrooms. 2012;14(5):427-46.

Kevin Spelman et al. (2017) Neurlogical Activity of Lion´s Mane (Hericium erinaceus). Journal Compilation

Lai, P.-L., Naidu, M., Sabaratnam, V., Wong, K.-H., David, R. P., Kuppusamy, U. R., … Malek, S. N. A. (2013). Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. International Journal of Medicinal Mushrooms, 15(6), 539–554.

Li, I.-C., Lee, L.-Y., Tzeng, T.-T., Chen, W.-P., Chen, Y.-P., Shiao, Y.-J., & Chen, C.-C. (2018). Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines. Behavioural Neurology, 2018, 5802634.

Menken, M., TL, M., & JF, T. (2000). The global burden of disease study: Implications for neurology. Archives of Neurology, 57(3), 418–420. Retrieved from

Mori K1, Obara Y, Hirota M, Azumi Y, Kinugasa S, Inatomi S, Nakahata N (2008)Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells.Biol Pharm Bull. 2008 Sep;31(9):1727-32.

Tsai-Teng, T., Chin-Chu, C., Li-Ya, L., Wan-Ping, C., Chung-Kuang, L., Chien-Chang, S., … Shiao, Y.-J. (2016). Erinacine A-enriched Hericium erinaceusmycelium ameliorates Alzheimer’s disease-related pathologies in APPswe/PS1dE9 transgenic mice. Journal of Biomedical Science, 23, 49.

Zhang, C.-C., Cao, C.-Y., Kubo, M., Harada, K., Yan, X.-T., Fukuyama, Y., & Gao, J.-M. (2017). Chemical Constituents from Hericium erinaceus Promote Neuronal Survival and Potentiate Neurite Outgrowth via the TrkA/Erk1/2 Pathway. International Journal of Molecular Sciences, 18(8).

Promotional feature:

  1. Ahn WS, Kim DJ, Chae GT, Lee JM, Bae SM, Sin JI, Kim YW, Namkoong SE, Lee IP (2004). Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Int J Gynecol Cancer 14:589-94.
  2. Ahn WS, Kim DJ, Chae GT, Lee JM, Bae SM, Sin JI, Kim YW, Namkoong SE, Lee IP (2004). Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Int J Gynecol Cancer 14:589-94.
  3. Cui XY, Cui SY, Zhang J, Wang ZJ, Yu B, Sheng ZF, Zhang XQ, Zhang YH (2012). Extract of Ganoderma lucidum prolongs sleep time in rats. J Ethnopharmacol 139(3):796-800.
  4. Dai Yu-C, Yang Z-L, Cui B-K, et al (2009). Species diversity and utilization of medicinal mushrooms and fungi in China (review). Int J Med Mush: 11: 287−302.
  5. Horneber M1, Bueschel G, Dennert G, Less D, Ritter E, Zwahlen M. How many cancer patients use complementary and alternative medicine: a systematic review and metaanalysis. Integr Cancer Ther. 2012 Sep;11(3):187-203. doi: 10.1177/1534735411423920. Epub 2011 Oct 21.
  6. Li EK, Tam LS, Wong CK, Li WC, Lam CWK, Wachtel-Galor S, Benzie IFF, Bao YX, Leung PC, Tomlinson B (2007). Safety and Efficacy of Ganoderma lucidum (Lingzhi) and San Miao San Supplementation in Patients With Rheumatoid Arthritis: A Double-Blind, Randomized, Placebo-Controlled Pilot Trial. Arthritis & Rheumatism (Arthritis Care & Research) 57, 1143–1150.
  7. Oba K, Teramukai S, Kobayashi M,·Matsui T,·Kodera Y,·Sakamoto Y (2007) Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curative resections of gastric cáncer. Cancer Immunology, Immunotherapy 56, 905-911.
  8. Ohwada S, Ogawa T, Makita F, Tanahashi Y, Ohya T, Tomizawa N, Satoh Y, Kobayashi I, Izumi M, Takeyoshi I, Hamada K, Minaguchi S, Togo Y, Toshihiko T, Koyama T, Kamio M (2006). Beneficial effects of protein-bound polysaccharide K plus tegafur/uracil in patients with stage II or III colorectal cancer: analysis of immunological parameters. Oncol Rep 15:861-8.
  9. Okuno K, Uno K (2011). Efficacy of orally administered Lentinula edodes mycelia extract for advanced gastrointestinal cancer patients undergoing cancer chemotherapy: a pilot study. Asian Pac J Cancer Prev. 12(7):1671-4.
  10. Roca-Lema D, Martinez-Iglesias O, Fernández de Ana Portela C, Rodríguez-Blanco A, Valladares-Ayerbes M, Díaz-Díaz A, Casas-Pais A, Prego C, Figueroa A. In Vitro Anti-proliferative and Anti-invasive Effect of Polysaccharide-rich Extracts from Trametes Versicolor and Grifola Frondosa in Colon Cancer Cells. Int J Med Sci 2019; 16(2):231-240. doi:10.7150/ijms.28811
  11. Sakamoto J, Morita S, Oba K, Matsui T, Kobayashi M, Nakazato H, Ohashi Y (2006) Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curatively resected colorectal cancer: a meta-analysis of centrally randomized controlled clinical trials. Cancer Immunology, Immunotherapy 55, 404-411.
  12. Standish LJ, Alschuler LN, Weaver M, Nezami M (2014). Botanical and mycological medicine in integrative oncology, in Integrative Oncology ed. Donald I. Abrans, Andrew Weil Oxford University Press.
  13. Torkelson CJ, Sweet E, Martzen MR, Sasagawa M, Wenner CA, Gay J, Putiri A, Standish LJ (2012). Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer. ISRN Oncol. 2012; 2012: 251632.
April 2019


Thermally Abused Frying Oil Potentiates Metastasis to Lung in a Murine Model of Late-Stage Breast Cancer. Anthony Cam et al. Cancer Prev Res March 18 2019. DOI: 10.1158/1940-6207.CAPR-18-0220.

Takashi Mori, Naoki Koyama, Jun Tan, Tatsuya Segawa, Masahiro Maeda, Terrence Town. Combined treatment with the phenolics (−)-epigallocatechin-3-gallate and ferulic acid improves cognition and reduces Alzheimer-like pathology in miceJournal of Biological Chemistry, 2019; 294 (8): 2714 DOI: 10.1074/jbc.RA118.004280.

Lei Feng, Irwin Kee-Mun Cheah, Maisie Mei-Xi Ng, Jialiang Li, Sue Mei Chan, Su Lin Lim, Rathi Mahendran, Ee-Heok Kua, Barry Halliwell. The Association between Mushroom Consumption and Mild Cognitive Impairment: A Community-Based Cross-Sectional Study in SingaporeJournal of Alzheimer’s Disease, 2019; 1 DOI: 10.3233/JAD-180959.

Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality. Victor W. Zhong, PhD1Linda Van Horn, PhD1Marilyn C. Cornelis, PhD1; et alJohn T. Wilkins, MD, MS1Hongyan Ning, MD, MS1Mercedes R. Carnethon, PhD1Philip Greenland, MD1Robert J. Mentz, MD2,3Katherine L. Tucker, PhD4Lihui Zhao, PhD1Arnita F. Norwood, PhD5Donald M. Lloyd-Jones, MD, ScM1Norrina B. Allen, PhD1

JAMA. 2019;321(11):1081-1095. doi:10.1001/jama.2019.1572.

The effect of Lactobacillus reuteri supplementation in Helicobacter pylori

infection: a placebo-controlled, single-blind study. Martin Buckley et al. BMC Nutrition, 2018, 4:48:


  1. World Health Organization. The World Health Report 2002: Reducing Risks, Promoting Healthy Life. 2002.
  2. Baxter AJ, Scott KM, Vos T, Whiteford HA. Global prevalence of anxiety disorders: a systematic review and meta-regression. Psychol Med. 2013 May;43(5):897-910.
  3. Smith K. Mental health: a world of depression. Nature. 2014 Nov 13;515(7526):181.
  4. Dale E, Bang-Andersen B, Sánchez C. Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs. Biochem Pharmacol. 2015 May 15;95(2):81-97.
  5. Pandarakalam JP. Challenges of Treatment-resistant Depression. Psychiatr Danub. 2018 Sep;30(3):273-284.
  6. Liu B, Liu J, Wang M, Zhang Y, Li L. From Serotonin to Neuroplasticity:
  7. Evolvement of Theories for Major Depressive Disorder. Front Cell Neurosci. 2017 Sep 28;11:305.
  8. Jentsch MC, Van Buel EM, Bosker FJ, Gladkevich AV, Klein HC, Oude Voshaar RC,  Ruhé EG, Eisel UL, Schoevers RA. Biomarker approaches in major depressive disorder evaluated in the context of current hypotheses. Biomark Med. 2015;9(3):277-97.
  9. Sarris J, Logan AC, Akbaraly TN, Amminger GP, Balanzá-Martínez V, Freeman MP,  Hibbeln J, Matsuoka Y, Mischoulon D, Mizoue T, Nanri A, Nishi D, Ramsey D, Rucklidge JJ, Sanchez-Villegas A, Scholey A, Su KP, Jacka FN; International Society for Nutritional Psychiatry Research. Nutritional medicine as mainstream in psychiatry. Lancet Psychiatry. 2015 Mar;2(3):271-4.
  10. Manosso LM, Moretti M, Rodrigues AL. Nutritional strategies for dealing with depression. Food Funct. 2013 Dec;4(12):1776-93
  11. Gadad BS, Jha MK, Czysz A, Furman JL, Mayes TL, Emslie MP, Trivedi MH. Peripheral biomarkers of major depression and antidepressant treatment response: Current knowledge and future outlooks. J Affect Disord. 2018 Jun;233:3-14.
  12. Montgomery SA, Thal LJ, Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment  of mild cognitive impairment and mild Alzheimer’s disease. Int Clin Psychopharmacol. 2003 Mar;18(2):61-71.
  13. Veronese N, Stubbs B, Solmi M, Ajnakina O, Carvalho AF, Maggi S. Acetyl-L-Carnitine Supplementation and the Treatment of Depressive Symptoms: A Systematic Review and Meta-Analysis. Psychosom Med. 2018 Feb/Mar;80(2):154-159.
  14. Nasca C, Bigio B, Lee FS, Young SP, Kautz MM, Albright A, Beasley J, Millington DS, Mathé AA, Kocsis JH, Murrough JW, McEwen BS, Rasgon N. Acetyl-l-carnitine deficiency in patients with major depressive disorder. Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):8627-8632.
  15. Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R.  Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review. Neurosci Biobehav Rev. 2015 Aug;55:294-321.
  16. Dean O, Giorlando F, Berk M. N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action. J. Psychiatry Neurosci. 2011;36:78–86
  17. Conus P, Seidman LJ, Fournier M, Xin L, Cleusix M, Baumann PS, Ferrari C, Cousins A, Alameda L, Gholam-Rezaee M, Golay P, Jenni R, Woo TW, Keshavan MS, Eap CB, Wojcik J, Cuenod M, Buclin T, Gruetter R, Do KQ. N-acetylcysteine in a Double-Blind Randomized Placebo-Controlled Trial: Toward Biomarker-Guided Treatment in Early Psychosis. Schizophr Bull. 2018 Feb 15;44(2):317-327.
  18. McNamara RK, Strawn JR. Role of Long-Chain Omega-3 Fatty Acids in Psychiatric  Practice. PharmaNutrition. 2013 Apr;1(2):41-49.
  19. Kirkland AE, Sarlo GL, Holton KF. The Role of Magnesium in Neurological Disorders. Nutrients. 2018 Jun 6;10(6).
  20. Rajizadeh A, Mozaffari-Khosravi H, Yassini-Ardakani M, Dehghani A. Effect of magnesium supplementation on depression status in depressed patients with magnesium deficiency: A randomized, double-blind, placebo-controlled trial. Nutrition. 2017 Mar;35:56-60.
  21. Zhang M, Robitaille L, Eintracht S, Hoffer LJ. Vitamin C provision improves mood in acutely hospitalized patients. Nutrition. 2011 May;27(5):530-3.
  22. Smith AD, Refsum H. Homocysteine, B Vitamins, and Cognitive Impairment. Annu Rev Nutr. 2016 Jul 17;36:211-39.
  23. Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy–A Review. Nutrients. 2016 Jan 27;8(2):68.
  24. Petrilli MA, Kranz TM, Kleinhaus K, Joe P, Getz M, Johnson P, Chao MV, Malaspina D. The Emerging Role for Zinc in Depression and Psychosis. Front Pharmacol. 2017 Jun 30;8:414.
  25. Karakuła-Juchnowicz H, Szachta P, Opolska A, Morylowska-Topolska J, Gałęcka M, Juchnowicz D, Krukow P, Lasik Z. The role of IgG hypersensitivity in the pathogenesis and therapy of depressive disorders. Nutr Neurosci. 2017 Feb;20(2):110-118.
  26. Bayes A, Parker G. How to choose an antidepressant medication. Acta Psychiatr  Scand. 2019 Mar;139(3):280-291.

International Society for Nutritional Psychiatry Research consensus position statement: nutritional medicine in modern psychiatry. World Psychiatry. 2015 Oct; 14(3): 370–371, doi: 10.1002/wps.20223.

Daniel F. Zegarra-Ruiz, Asmaa El Beidaq, Alonso J. Iñiguez, Martina Lubrano Di Ricco, Silvio Manfredo Vieira, William E. Ruff, Derek Mubiru, Rebecca L. Fine, John Sterpka, Teri M. Greiling, Carina Dehner, Martin A. Kriegel. A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic AutoimmunityCell Host & Microbe, 2018; DOI: 10.1016/j.chom.2018.11.009

Christopher E. Zwilling, Tanveer Talukdar, Marta K. Zamroziewicz, Aron K. Barbey. Nutrient biomarker patterns, cognitive function, and fMRI measures of network efficiency in the aging brain. NeuroImage, 2019; 188: 239 DOI: 10.1016/j.neuroimage.2018.12.007

Limon et al. Malassezia Is Associated with Crohn’s Disease and Exacerbates Colitis in Mouse Models. Cell Host & Microbe, 2019 DOI: 10.1016/j.chom.2019.01.007

Free fatty acids rewire cancer metabolism in obesity-associated breast cancer via estrogen receptor and mTOR signaling

Zeynep Madak-Erdogan et al. Cancer Research 2019, Published OnlineFirst March 12,
doi: 10.1158/0008-5472.CAN-18-2849.


Akihito Harusato, Emilie Viennois, Lucie Etienne-Mesmin, Shingo Matsuyama, Hirohito Abo, Satoru Osuka, Nicholas W Lukacs, Yuji Naito, Yoshito Itoh, Jian-Dong Li, Didier Merlin, Andrew T. Gewirtz, Timothy L. Denning. Early-life microbiota exposure restricts myeloid-derived suppressor cell-driven colonic tumourigenesisCancer Immunology Research, 2019; canimm.0444.2018 DOI: 10.1158/2326-6066.CIR-18-0444

Human Gut Microbiome Response Induced by Fermented Dairy Product Intake in Healthy Volunteers. Olesya Volokh et al. Nutrients. 4 Mar 2019.

 Association of Maternal Probiotic Supplementation With Human Milk Oligosaccharide Composition. Research Letter. Antti E. Seppo et al. JAMA Pediatr. 2019;173(3):286-288. doi:10.1001/jamapediatrics.2018.4835.

Vienna E. Brunt et al. Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in miceThe Journal of Physiology, 2019; DOI: 10.1113/JP277336


A genome-wide cross trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. Zhaozhong Zhu, Phil Hyoun Lee, et al.  Nature Genetics 2018, DOI:10.1038/s41588-018-0121-0.

Daniel Reker, Steven M. Blum, Christoph Steiger, Kevin E. Anger, Jamie M. Sommer, John Fanikos and Giovanni Traverso. Inactive” ingredients in oral medicationsScience Translational Medicine, 2019 DOI: 10.1126/scitranslmed.aau6753

Healthy infants harbor intestinal bacteria that protect against food allergy

Taylor Feehley et al. Nature Medicine 2019, 25:448–53.

Histamine-releasing factor enhances food allergy.

Ando T et al. J Clin Invest. 2017 Dec 1;127(12):4541-4553. doi: 10.1172/JCI96525.

In Focus Supplement - April 2019

Sarah Oboh:

  1. Maintz, L and Novak, N. (2007) Histamine and histamine intolerance. Am J Clin Nutr. 85(5):1185-1196.
  2. Izquierdo-Casas, J. et al. (2018) Diamine oxidase (DAO) supplement reduces headache in episodic migraine patients with DAO deficiency: A randomized double-blind trial. Clin Nutr. doi: 10.1016/j.clnu.2018.01.013. [Epub ahead of print].
  3. Schmidt WU, Sattler J, Hesterberg R, et al. .Human intestinal diamine oxidase (DAO) activity in Crohn’s disease: a new marker for disease assessment? Agents Actions 1990;30:267–70.
  4. Mennigen R, Kusche J, Streffer C, Krakamp B. Diamine oxidase activities in the large bowel mucosa of ulcerative colitis patients. Agents Actions  1990;30:264–6.
  5. Guslandi, M. et al. (2003) A pilot trial of Saccharomyces boulardii in ulcerative colitis. European Journal of Gastroenterology & Hepatology. Vol. 15 pp. 697 – 698.
  6. McFarland L.V., (2010), ‘Systematic review and meta-analysis of Saccharomyces boulardii in adult patients’. World Journal of Gastroenterology, 16(18):2202–2222. 
  7. Kotowska M. et al., (2005), ‘Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea in children: a randomized double-blind placebo-controlled trial’.Alimentary Pharmacology & Therapeutics, 21(5):583–590.
  8. Krämer, S. et al. (2008). Selective Activation of Human Intestinal Mast Cells by Escherichia coli Hemolysin. J Immunol. 181 (2) 1438-1445. 
  9. Hung, CR. (2005) Modulation of gastric hemorrhage and ulceration by oxidative stress and histamine release in Salmonella typhimurium-infected rats. Inflammopharmacology. 13(1-3):235-48. 
  10. Vighi, G. et al (2008) Allergy and the gastrointestinal system. Clin. Exp. Immunol. Sept;153(1):3-6  
  11. Dev, S., Mizuguchi, H., Das, A. K., Matsushita, C., Maeyama, K., Umehara, H., … & Fukui, H. (2008). Suppression of histamine signaling by probiotic Lac-B: a possible mechanism of its anti-allergic effect. Journal of pharmacological sciences, 107(2), 159-166
  12. Galdeano CM et al., (2004) Role of viability of probiotic strains in their persistence in the gut and in mucosal immune stimulation. J Appl Microbiol. 2004;97(4):673-81

Penny Shaw: (bland, J 2016) (Wallace, M 2014). (Detzel, C 2015) (Nebot-vivinus, M 2014) (Marchbank, T 2011) (Miller A, 1999) (Van der Hulst, 1993) (Deloose, 2016) (Nieuwenhuji, V et al, 1998) ( Miyano, et al 2013) (Adzet, T 1987) (Kraft, K 1998)

Aicacia Young:

  1. Mosca A, et al. Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem? Front Microbiol. 2016;7:455.
  2. Le Chatelier E, et al. Richness of human gut microbiome correlates with metabolic markers. Nature. 2013;500:541-546.
  3. Lingheim L, et al. Alterations in Gut Microbiome Composition and Barrier Function Are Associated with Reproductive and Metabolic Defects in Women with Polycystic Ovary Syndrome (PCOS): A Pilot Study. PLoS One. 2017;12(1):e0168390.
  4. Chelakkot C, et al. Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions. Exp & Molecular Med. 2018;50:e450.
  5. Dao MC, et al. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut. 2016;65:426-436.
  6. Schneeberger M, et al. Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice. Scientific Reports. 2015; 5:16643.
  7. Martin R, et al. Functional Characterization of Novel Faecalibacterium prausnitzii Strains Isolated from Healthy Volunteers: A Step Forward in the Use of F. prausnitzii as a Next-Generation Probiotic. Front Microbiol. 2017; 8: 1226.
  8. Picard C, et al. Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits. Aliment Pharmacol Ther.  2005;22:495–512.
  9. Stenman LK, et al. Potential probiotic Bifidobacterium animalis ssp. lactis 420 prevents weight gain and glucose intolerance in diet-induced obese mice. Benef Microbes. 2014;5(4):437-445.
  10. Collado MC, et al. Imbalances in fecal and duodenal Bifidobacterium species composition in active and non-active celiac disease. BMC Microbiol. 2008;8:232.
  11. Gao X, et al. Obesity in school-aged children and its correlation with gut E. coli and Bifidobacteria: a case-control study. BMC Pediatr. 2015;15:64.
  12. Akay HK, et al. The relationship between bifidobacterial and allergic asthma and/or allergic dermatitis: a prospective study of 0-3-year-old children in Turkey. Anaerobe. 2014;28:98-103.
  13. Possemiers S, et al. Evaluation of the Bacillus subtilis strain HU-58 in the SHIME technology platform. ProDigest Final Report. 2013: 1-40.
  14. Blatchford P, et al. Consumption of kiwifruit capsules increases Faecalibacterium prausnitzii abundance in functionally constipated individuals: a randomized controlled human trial. J Nutr Sci. 2017; 6: e52.
  15. Everard A, Lazarevic V, Derrien M, et al. Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice. Diabetes. 2011 Nov; 60(11): 2775–2786.
  16. Finegold SM, et al. Xylooligosaccharide increases bifidobacteria but not lactobacilli in human gut microbiota. Food Funct. 2014;5(3):436-45.
  17. Depeint F, et al. Prebiotic evaluation of a novel galactooligosaccharide mixture produced by the enzymatic activity of Bifidobacterium bifidum NCIMB 41171, in healthy humans: a randomized, double-blind, crossover, placebo-controlled intervention study 1–3. Am J Clin Nutr. 2008;87(3):785-91.
  18. Faure M, et al. Specific Amino Acids Increase Mucin Synthesis and Microbiota in Dextran Sulfate Sodium–Treated Rats. J Nutr. 2006;136(6):1558-64.


  1. Citi S. Intestinal barriers protect against disease. Science. 2018;359(6380):1097-1098.
  1. Michielan A, et al. Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut. Mediators Inflamm. 2015; 2015:628157.
  1. Maes M, et al. The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. Neuro Endocrinol Lett. 2008;29(1):117-24.
  1. Paiardini M, et al. Mucosal immune dysfunction in AIDS pathogenesis. AIDS Rev. 2008;10(1):36-46.
  1. Kandulski A, et al. Gastroesophageal reflux disease–from reflux episodes to mucosal inflammation. Nat Rev Gastroenterol Hepatol. 2011;9(1):15-22.
  1. Liu H, et al. Early gut mucosal dysfunction in patients with acute pancreatitis. Pancreas. 2008;36(2):192-6.
  1. de Punder K, et al. Stress Induces Endotoxemia and Low-Grade Inflammation by Increasing Barrier Permeability. Front Immunol. 2015;6:223.
  1. Schmitz H, et al. Tumor necrosis factor alpha (TNFα) regulates the epithelial barrier in the human intestinal cell line HT-29/B6. Journal of Cell Science. 1999;112(1):137–146.
  1. Coskun M. Intestinal epithelium in inflammatory bowel disease. Front Med. 2014;1:24.
  1. Su L, et al. TNFR2 activates mlck-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis. Gastroenterology. 2013;145(2):407–415.
  1. Vinolo MAR, et al. Regulation of Inflammation by Short Chain Fatty Acids. Nutrients. 2011; 3(10): 858–876.
  1. Matsuoka K, et al. The gut microbiota and inflammatory bowel disease. Semin Immunopathol. 2015; 37: 47–55.
  1. Detzel CJ, et al. Bovine immunoglobulin/protein isolate binds pro-inflammatory bacterial compounds and prevents immune activation in an intestinal co-culture model. PloS one. 2015;10(4):e0120278.
  1. Faure M, et al. Specific Amino Acids Increase Mucin Synthesis and Microbiota in Dextran Sulfate Sodium–Treated Rats. J Nutr. 2006;136(6):1558-64.
  1. Mosca A, et al. Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem? Front Microbiol. 2016;7:455.
  2. Le Chatelier E, et al. Richness of human gut microbiome correlates with metabolic markers. Nature. 2013;500:541-546.
  3. Lingheim L, et al. Alterations in Gut Microbiome Composition and Barrier Function Are Associated with Reproductive and Metabolic Defects in Women with Polycystic Ovary Syndrome (PCOS): A Pilot Study. PLoS One. 2017;12(1):e0168390.
  4. Chelakkot C, et al. Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions. Exp & Molecular Med. 2018;50:e450.
  5. Dao MC, et al. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut. 2016;65:426-436.
  6. Schneeberger M, et al. Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice. Scientific Reports. 2015; 5:16643.
  7. Martin R, et al. Functional Characterization of Novel Faecalibacterium prausnitzii Strains Isolated from Healthy Volunteers: A Step Forward in the Use of F. prausnitzii as a Next-Generation Probiotic. Front Microbiol. 2017; 8: 1226.
  8. Picard C, et al. Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits. Aliment Pharmacol Ther.  2005;22:495–512.
  9. Stenman LK, et al. Potential probiotic Bifidobacterium animalis ssp. lactis 420 prevents weight gain and glucose intolerance in diet-induced obese mice. Benef Microbes. 2014;5(4):437-445.
  10. Collado MC, et al. Imbalances in fecal and duodenal Bifidobacterium species composition in active and non-active celiac disease. BMC Microbiol. 2008;8:232.
  11. Gao X, et al. Obesity in school-aged children and its correlation with gut E. coli and Bifidobacteria: a case-control study. BMC Pediatr. 2015;15:64.
  12. Akay HK, et al. The relationship between bifidobacterial and allergic asthma and/or allergic dermatitis: a prospective study of 0-3-year-old children in Turkey. Anaerobe. 2014;28:98-103.
  13. Possemiers S, et al. Evaluation of the Bacillus subtilis strain HU-58 in the SHIME technology platform. ProDigest Final Report. 2013: 1-40.
  14. Blatchford P, et al. Consumption of kiwifruit capsules increases Faecalibacterium prausnitzii abundance in functionally constipated individuals: a randomized controlled human trial. J Nutr Sci. 2017; 6: e52.
  15. Everard A, Lazarevic V, Derrien M, et al. Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice. Diabetes. 2011 Nov; 60(11): 2775–2786.
  16. Finegold SM, et al. Xylooligosaccharide increases bifidobacteria but not lactobacilli in human gut microbiota. Food Funct. 2014;5(3):436-45.
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Adrienne Benjamin:

[1] Dukowicz AC, Lacy BE & Levine GM (2007) Small Intestinal Bacterial Overgrowth: A Comprehensive Review Gasterenterol Hepatol 3(2):112-122

2 Bures J et al (2010) Small intestinal bacterial overgrowth syndrome World J Gastroenterol 16(24):2978-2990

3 Pyleris E et al (2012) The Prevalence of Overgrowth by Aerobic Bacteria in the Small Intestine by Small Bowel Culture: Relationship with Irritable Bowel Syndrome Dig Dis Sci 57:1321-1329

4 Shah A et al (2019) Systematic Review with meta-analysis: the prevalence of small intestinal bacterial overgrowth in inflammatory bowel disease Aliment Pharmacol Ther 49:624-635

5 Ghoshal UD, Srivastava D (2014) Irritable bowel syndrome and small intestinal bacterial overgrowth: Meaningful association or unnecessary hype World J Gastroenterol 20(10):2482-2491

6 Salem A & Ronald BC (2014) Small Intestinal Bacterial Overgrowth (SIBO) J Gastroint Dig Syst 4:225

7 Dukowicz AC, Lacy BE & Levine GM (2007) Small Intestinal Bacterial Overgrowth: A Comprehensive Review Gasterenterol Hepatol 3(2):112-122

8 Quigley EMM (2019) The Spectrum of Small Intestinal Bacterial Overgrowth (SIBO) Curr Gastroenterol Rep

9 Grace, E et al (2013) Review article: small intestinal bacterial overgrowth – prevalence, clinical features, current and developing diagnostic tests, and treatment Aliment Pharmacol Ther 38:674-688

10 Choung RS et al (2011) Clinical predictors of small intestinal bacterial overgrowth by duodenal aspirate culture

11 Chen B et al (2017) Prevalence and predictors of small intestinal bacterial overgrowth in irritable bowel syndrome: a systemic review and meta-analysis. J Gastroenterol

12 Su T et al (2018) Meta-analysis: proton pump inhibitors moderately increase the risk of small intestinal bacterial overgrowth J of Gastroenterol 53(1):27-36

13 Adike A & DiBaise JK (2017) Small Intestinal Bacterial Overgrowth – Nutritional Implications, Diagnosis, and Management Gastroenterol Clin N Am

14 Gewecke K, Nannen-Ottens S (2017) Bacterial overgrowth: nutrition as part of the therapeutic concept Ernahrungs Umschau 64(4):67-73; 64(5):74-78

15 Chen WC & Quigley EMM (2014) Probiotics, prebiotics & synbiotics in small intestinal bacterial overgrowth:

16 Shah SC et al (2013) Meta-analysis: antibiotic therapy for small intestinal bacterial overgrowth Aliment Pharmacol Ther 2013 28:925-934

17 Gatta L & Scarpignato C (2017) Systematic review with meta-analysis: rifaximin is effective and safe for the treatment of small intestine bacterial overgrowth Aliment Pharmacol Ther 45:604-616

18 McIntosh K et al (2016) FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial Gut 0 :1-11

19 Magge S & Lembo A (2012) Low-FODMAP Diet for Treatment of Irritable Bowel Syndrome Gastroenterol Hepatol 8(11):739-745

20 Altobelli E et al (2017) Low-FODMAP Diet Improves Irritable Bowel Syndrome Symptoms: A Meta-Analysis Nutrients 9:940; doi:10.3390/nu9090940

21 Konturek PC, Brzozowski T, Konturek SJ (2011) Stress and the gut: Pathophysiology, clinical consequences, diagnostic approach and treatment options J Physiol Pharmacol 62(6):591-599

22 Chedid V et al Herbal Therapy Is Equivalent to Rifaximin for the Treatment of Small Intestinal Bacterial Overgrowth Global Adv Health Med 3(3):16-24

23 Zhong C et al (2017) Probiotics for Preventing and Treating Small Intestinal Bacterial Overgrowth: A Meta-Analysis and Systematic Review of Current Evidence J Clin Gastroenterol 51:300-311


March 2019


Ana Rodriguez-Mateos, Geoffrey Istas, Lisa Boschek, Rodrigo P Feliciano, Charlotte E Mills, Céline Boby, Sergio Gomez-Alonso, Dragan Milenkovic, Christian Heiss. Circulating anthocyanin metabolites mediate vascular benefits of blueberries: insights from randomized controlled trials, metabolomics, and nutrigenomicsThe Journals of Gerontology: Series A, 2019; DOI: 10.1093/gerona/glz047

Zgaga, L.; Laird, E.; Healy, M. 25-Hydroxyvitamin D Measurement in Human Hair: Results from a Proof-of-Concept study. Nutrients 201911, 423.

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease. Toufic Mayassi et al. Cell 2019, 176: 5. DOI:

Adjunctive vitamin D in tuberculosis treatment: meta-analysis of individual participant data. David A. Jolliffe, Davaasambuu Ganmaa, Christian Wejse, Rubhana Raqib, Md. Ahsanul Haq, Nawal Salahuddin, Peter K. Daley, Anna P. Ralph, Thomas R. Ziegler and Adrian R. Martineau. European Respiratory Journal, Published online February 6, 2019.

Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross‐over trial. Shaun A. Mason et al. Diabetes, Obesity and Metabolism, First published: 04 November 2018.

Lund KS, Siersma V, Brodersen J, et al. Efficacy of a standardised acupuncture approach for women with bothersome menopausal symptoms: a pragmatic randomised study in primary care (the ACOM study). BMJ Open 2019;9:e023637. doi: 10.1136/bmjopen-2018-023637.


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  20. Frary JM, Bjerre KP, Glintborg D, Ravn P. The effect of dietary carbohydrates  in women with polycystic ovary syndrome: a systematic review. Minerva Endocrinol. 2016 Mar;41(1):57-69.
  21. Sordia-Hernández LH, Ancer Rodríguez P, Saldivar Rodriguez D, Trejo Guzman S,Servín Zenteno ES, Guerrero González G, Ibarra Patiño R. Effect of a low glycemic diet in patients with polycystic ovary syndrome and anovulation – a randomized controlled trial. Clin Exp Obstet Gynecol. 2016;43(4):555-559.
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  50. Javanmanesh F, Kashanian M, Rahimi M, Sheikhansari N. A comparison between the effects of metformin and N-acetyl cysteine (NAC) on some metabolic and endocrine  characteristics of women with polycystic ovary syndrome. Gynecol Endocrinol. 2016;32(4):285-9.
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  53. Hajimonfarednejad M, Nimrouzi M, Heydari M, Zarshenas MM, Raee MJ, Jahromi BN. Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: A randomized double-blind placebo controlled clinical trial. Phytother Res. 2018 Feb;32(2):276-283.
  54. Akdoğan M, Tamer MN, Cüre E, Cüre MC, Köroğlu BK, Delibaş N. Effect of spearmint (Mentha spicata Labiatae) teas on androgen levels in women with hirsutism. Phytother Res. 2007 May;21(5):444-7.
  55. Grant P. Spearmint herbal tea has significant anti-androgen effects in polycystic ovarian syndrome. A randomized controlled trial. Phytother Res. 2010 Feb;24(2):186-8
  56. Haj-Husein I, Tukan S, Alkazaleh F. The effect of marjoram (Origanum majorana) tea on the hormonal profile of women with polycystic ovary syndrome: a randomised controlled pilot study. J Hum Nutr Diet. 2016 Feb;29(1):105-11.
  57. Heidary M, Yazdanpanahi Z, Dabbaghmanesh MH, Parsanezhad ME, Emamghoreishi M,  Akbarzadeh M. Effect of chamomile capsule on lipid- and hormonal-related parameters among women of reproductive age with polycystic ovary syndrome. J Res  Med Sci. 2018 Apr 26;23:33.

HYBRID DIET – Patrick Holford

  1. Sarah J. Hallberg et al Effectiveness and Safety of a Novel Care Model for the Management of Type 2 Diabetes at 1 Year: An Open-Label, Non-Randomized, Controlled Study

Diabetes Therapy April 2018, Volume 9, Issue 2, pp 583–612.

  1. Courchesne-Loyer A, et al., ‘Inverse relationship between brain glucose and ketone metabolism in adults during short-term moderate dietary ketosis: A dual tracer quantitative positron emission tomography study.’ 2017 Jul;37(7):2485-2493; see also Cunnane SC et al., ‘Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer’s Disease.’J Cereb Blood Flow Metab. 2017 Jul;37(7):2485-2493
  3. Wang C1 et al Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases.Curr Opin Neurobiol. 2018 Feb;48:52-58.
  4. E. White, ‘Autophagy, metabolism, and cancer’, Clinical Cancer Research (2015), 21(22):5037–5046.
  5. Bueno NB et al Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials. Br J Nutr. 2013 Oct;110(7):1178-87.


  1. David S. Ludwig The case against carbohydrates gets stronger LA Times Nov 14, 2018
  2. J.M. Chan, et al., ‘Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study’, Science (1998), vol 279(5350):563–566; see also M.J. Gunter et al., ‘Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women’, Journal of the National Cancer Institute (2009), vol 101(1):48–60.=
  3. Vandenberghe et al., ‘Tricaprylin alone increases plasma ketone response more than coconut oil or other medium-chain triglycerides: an acute crossover study in healthy adults’, Current Developments in Nutrition (2017), vol 1(4):e000257.
    10. C. Ebbeling et al., ‘Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial’ British Medical Journal 2018;363:k4583
  4. P.M. Johnson and P.J. Kenny, ‘Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats’, Nature Neuroscience (2010), vol 13(5)–635–641.


Kim Vriens et al. Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticityNature, 2019; DOI: 10.1038/s41586-019-0904-1.

Jeewon Garcia-So, Xinwen Zhang, Xiaohua Yang, Mara Roxana Rubinstein, De Yu Mao, Jan Kitajewski, Kang Liu, Yiping W. Han. 

Omega-3 fatty acids suppress Fusobacterium nucleatum–induced placental inflammation originating from maternal endothelial cellsJCI Insight, 2019; 4 (3) DOI: 10.1172/jci.insight.125436.

Poorna ChandraRao Yalagala, Dhavamani Sugasini, Sridevi Dasarathi, Kalipada Pahan, Papasani V. Subbaiah. Dietary lysophosphatidylcholine-EPA enriches both EPA and DHA in the brain: Potential treatment for depressionJournal of Lipid Research, 2018; jlr.M090464 DOI: 10.1194/jlr.M090464.

Association of reported fish intake and supplementation status with the omega-3 index.

K.H. Jackson et al. Prostaglandins, Leukotrienes and Essential Fatty Acids

Vol142, March 2019, 4-10: DOI:

Marine fish oil is more potent than plant-based n-3 polyunsaturated fatty acids in the prevention of mammary tumors. JiajieLiu et al. The Journal of Nutritional Biochemistry

Volume 55, May 2018, Pages 41-52

LYME – Dr Bill Rawls.

  1. Berende A, ter Hofstede HJ, Vos FJ, et al. Randomized Trial of Longer-Term Therapy for Symptoms Attributed to Lyme Disease. N Engl J Med. 2016;374(13):1209-1220.
    2.Rudenko N, Golovchenko M, Vancova M, et al. Isolation of live Borrelia burgdorferi senso lato spirochaetes from patients with undefined disorders and symptoms not typical for Lyme borreliosis. Clin Microb Infect. 2016;22(3):267. Epub 2015 Dec 8.
    3. Perez-Cobas AE, Gosalbes MJ, Friedrichs A, et al. Gut microbiota disturbance during antibiotic therapy, a multi-omic approach. Gut. 2013;62(11):1591-1601. Epub 2012 Dec 12.
    4. Morgun A, Dzutsev A, Dong X, et al. Uncovering effects of antibiotics on the host and microbiota using transkingdom gene networks. Gut. 2015;64(11):1732-1742. Epub 2015 Jan 22.
    5. Kalghatgi S, Spina CS, Costello JC, et al. Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells. Sci Transl Med. 2013;5(192):192ra85.
    6. Macfarlane S, Woodmansey EJ, Macfarlane GT. Colonization of mucin by human intestinal bacteria and establishment of biofilm communities in a two-stage continuous culture system. Appl Environ Microbiol. 2005;71(11):7483-7492.
    7. Macfarlane S, Dillon JF. Microbial biofilms in the human gastrointestinal tract. J Appl Microbiol. 2007;102(5):1187-1196.
    8. Macfarlane S, Bahrami B, Macfarlane GT. Mucosal biofilm communities in the human intestinal tract. Adv Appl Microbiol. 2011;75:111-143.


Ting Fu et al. FXR Regulates Intestinal Cancer Stem Cell ProliferationCell, 2019; 176 (5): 1098 DOI: 10.1016/j.cell.2019.01.036.

Xin Wu, Jing Shi, Wan-xia Fang, Xiao-yu Guo, Ling-yun Zhang, Yun-peng Liu, Zhi Li. Allium vegetables are associated with reduced risk of colorectal cancer: A hospital-based matched case-control study in ChinaAsia-Pacific Journal of Clinical Oncology, 2019; DOI: 10.1111/ajco.13133


Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal. Doua Azzouz et al. Annals of the Rheumatic Diseases. Published Online First: 19 February 2019. doi: 10.1136/annrheumdis-2018-214856.

 Old age-associated phenotypic screening for Alzheimer’s disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa

Wolfgang Fischer, Antonio Currais, Zhibin Liang, Antonio Pinto and Pamela Maher.

Redox Biology, Volume 21, February 2019, 101089

open access:

Haruki Nakamura, Akinori Hara, Hiromasa Tsujiguchi, Thao Thi Thu Nguyen, Yasuhiro Kambayashi, Sakae Miyagi, Yohei Yamada, Keita Suzuki, Yukari Shimizu, Hiroyuki Nakamura. Relationship between Dietary n-6 Fatty Acid Intake and Hypertension: Effect of Glycated Hemoglobin LevelsNutrients, 2018; 10 (12): 1825 DOI: 10.3390/nu10121825

Stephen J. Carter, Gary R. Hunter, J. Walker Blackston, Nianjun Liu, Elliot J. Lefkowitz, William J. Van Der Pol, Casey D. Morrow, Jesseca A. Paulsen, Laura Q. Rogers. Gut microbiota diversity associates with cardiorespiratory fitness in post-primary treatment breast cancer survivorsExperimental Physiology, 2019; DOI: 10.1113/EP087404.

Philip Strandwitz, Ki Hyun Kim, Darya Terekhova, Joanne K. Liu, Anukriti Sharma, Jennifer Levering, Daniel McDonald, David Dietrich, Timothy R. Ramadhar, Asama Lekbua, Nader Mroue, Conor Liston, Eric J. Stewart, Marc J. Dubin, Karsten Zengler, Rob Knight, Jack A. Gilbert, Jon Clardy, Kim Lewis. GABA-modulating bacteria of the human gut microbiotaNature Microbiology, 2018; DOI: 10.1038/s41564-018-0307-3.

Asher Preska Steinberg, Sujit S Datta, Thomas Naragon, Justin C Rolando, Said R Bogatyrev, Rustem F Ismagilov. High-molecular-weight polymers from dietary fibre drive aggregation of particulates in the murine small intestineeLife, 2019 DOI: 10.7554/eLife.40387.001.

Luoping Zhang, Iemaan Rana, Rachel M. Shaffer, Emanuela Taioli, Lianne Sheppard. Exposure to Glyphosate-Based Herbicides and Risk for Non-Hodgkin Lymphoma: A Meta-Analysis and Supporting EvidenceMutation Research/Reviews in Mutation Research, 2019; DOI: 10.1016/j.mrrev.2019.02.001.

Petra Bacher et al. Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicansCell, 2019; DOI: 10.1016/j.cell.2019.01.041.

Puneet Seth, Paishiun N. Hsieh, Suhib Jamal, Liwen Wang, Steven P. Gygi, Mukesh K. Jain, Jeff Coller, Jonathan S. Stamler. Regulation of MicroRNA Machinery and Development by Interspecies S-NitrosylationCell, Feb. 21, 2019; DOI: 10.1016/j.cell.2019.01.037

AONM Advertorial:

1. Moutailler S, Valiente Moro C, Vaumourin E, Michelet L, Tran FH, Devillers E, et al. (2016)
Co-infection of Ticks: The Rule Rather Than the Exception. PLoS Negl Trop Dis 10(3):
2. Johnson, L., Wilcox, S., Mankoff, J., & Stricker, R. B. (2014). Severity of chronic Lyme disease
compared to other chronic conditions: a quality of life survey. PeerJ, 2, e322.
3. Birtles, R. J., Laycock, G., Kenny, M. J., Shaw, S. E. & Day, M. J. (2002). Prevalence of
Bartonella species causing bacteraemia in domesticated and companion animals in the
United Kingdom. Vet Rec 151, 225–229.
5. Davies, S, Abdullah, S, Helps, C, Tasker, S, Newbury, H & Wall, R 2017, ‘Prevalence of ticks
and tick-borne pathogens: Babesia and Borrelia species in ticks infesting cats of Great Britain’
Veterinary Parasitology, vol. 244, pp. 129-135
7. Mansfield, K. L., Jizhou, L., Phipps, L. P., & Johnson, N. (2017). Emerging Tick-Borne Viruses in
the Twenty-First Century. Frontiers in cellular and infection microbiology, 7, 298

February 2019


Martami F et al The effects of a multispecies probiotic supplement on inflammatory markers and episodic and chronic migraine characteristics: A randomized double-blind controlled trial. Cephalalgia. Jan 2019.

Christian Timbol, James Baraniuk. Chronic fatigue syndrome in the emergency departmentOpen Access Emergency Medicine, 2019; Volume 11: 15 DOI: 10.2147/OAEM.S176843

Qi Dai, Xiangzhu Zhu, JoAnn E Manson, Yiqing Song, Xingnan Li, Adrian A Franke, Rebecca B Costello, Andrea Rosanoff, Hui Nian, Lei Fan, Harvey Murff, Reid M Ness, Douglas L Seidner, Chang Yu, Martha J Shrubsole. Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trialThe American Journal of Clinical Nutrition, 2018; 108 (6): 1249 DOI: 10.1093/ajcn/nqy274

Anne Marie Uwitonze, Mohammed S. Razzaque. Role of Magnesium in Vitamin D Activation and FunctionThe Journal of the American Osteopathic Association, 2018; 118 (3): 181 DOI: 10.7556/jaoa.2018.037

Chester R, Khondoker M, Shepstone L, et al. Self-efficacy and risk of persistent shoulder pain: results of a Classification and Regression Tree (CART) analysis

Br J Sports Med Published Online First: 09 January 2019. doi: 10.1136/bjsports-2018-099450.

Kate L Mandeville, Rosie Barker, Alice Packham, Charlotte Sowerby, Kielan Yarrow, Hannah Patrick. Financial interests of patient organisations contributing to technology assessment at England’s National Institute for Health and Care Excellence: policy review.BMJ. DOI: 10.1136/BMJ.K5300

Hall, K et al. COMT modifies alpha-tocopherol effects in cancer prevention: gene-supplement interactions in two randomized clinical trialsJNCI, 2019 DOI: 10.1093/jnci/djy204.

Tamara Lucas, Richard Horton. The 21st-century great food transformationThe Lancet, 2019; DOI: 10.1016/S0140-6736(18)33179-9.


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Yifan Wu, Shuqi Du, Jennifer L. Johnson, Hui-Ying Tung, Cameron T. Landers, Yuwei Liu, Brittany G. Seman, Robert T. Wheeler, Mauro Costa-Mattioli, Farrah Kheradmand, Hui Zheng, David B. Corry. Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficitsNature Communications, 2019; 10 (1) DOI: 10.1038/s41467-018-07991-4

Kristin M. Wall, William Kilembe, Bellington Vwalika, Cecile Dinh, Paul Livingston, Yeuk-Mui Lee, Shabir Lakhi, Debi Boeras, Htee Khu Naw, Ilene Brill, Elwyn Chomba, Tyronza Sharkey, Rachel Parker, Erin Shutes, Amanda Tichacek, W. Evan Secor, Susan Allen. Schistosomiasis is associated with incident HIV transmission and death in Zambia. PLOS Neglected Tropical Diseases, 2018; 12 (12): e0006902 DOI: 10.1371/journal.pntd.0006902.

Pilling Luke C, Tamosauskaite Jone, Jones Garan, Wood Andrew R, Jones Lindsay, Kuo Chai-Ling et al. Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank BMJ 2019; 364 :k5222.

Jone Tamosauskaite, Janice L Atkins, Luke C Pilling, Chia-Ling Kuo, George A Kuchel, Luigi Ferrucci, David Melzer; Hereditary Hemochromatosis Associations with Frailty, Sarcopenia and Chronic Pain: Evidence from 200,975 Older UK Biobank Participants, The Journals of Gerontology: Series A, gly270,

Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47−mediated ‘don’t-eat-me’ signal, Nature Immunology (2019). DOI: 10.1038/s41590-018-0292-y ,

Brooke C. Wilson, Tommi Vatanen, Wayne S. Cutfield, Justin M. O’Sullivan. The Super-Donor Phenomenon in Faecal Microbiota TransplantationFrontiers in Cellular and Infection Microbiology, 2019; 9 DOI: 10.3389/fcimb.2019.00002

Suzanna Maria Zick, Ananda Sen, Afton Luevano Hassett, Andrew Schrepf, Gwen Karilyn Wyatt, Susan Lynn Murphy, John Todd Arnedt, Richard Edmund Harris. Impact of Self-Acupressure on Co-Occurring Symptoms in Cancer SurvivorsJNCI Cancer Spectrum, 2018; 2 (4) DOI: 10.1093/jncics/pky064

Marta Gallego et al. Peptides with Potential Cardioprotective Effects Derived from Dry-Cured Ham ByproductsJournal of Agricultural and Food Chemistry, 2019; DOI: 10.1021/acs.jafc.8b05888.

Maria A Lankinen, Alexander Fauland, Bun-ichi Shimizu, Jyrki Ågren, Craig E Wheelock, Markku Laakso, Ursula Schwab, Jussi Pihlajamäki. Inflammatory response to dietary linoleic acid depends on FADS1 genotypeThe American Journal of Clinical Nutrition, 2019; DOI: 10.1093/ajcn/nqy287

Kenichiro Kinouchi, Christophe Magnan, Nicholas Ceglia, Yu Liu, Marlene Cervantes, Nunzia Pastore, Tuong Huynh, Andrea Ballabio, Pierre Baldi, Selma Masri, Paolo Sassone-Corsi. Fasting Imparts a Switch to Alternative Daily Pathways in Liver and MuscleCell Reports, 2018; 25 (12): 3299 DOI: 10.1016/j.celrep.2018.11.077

January 2019

IHCAN January 2018 references

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  32. Olah et al 92014) Cannbidiol exerts sebostatic and anti-inflammatory effects on human sebocytes. J Clin Invest 124:3713-3724
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  40. Stott et al (2013). A phase I, open-label, randomized, crossover study in three parallel groups to evaluate the effect of Rifampicin, Ketoconazole, and Omeprazole on the phamacokinetics of THC/CBD oromucosal spray in healthy volunteers. SpringerPlus 2:236

Endocannabinoid deficiency

  1. Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes. Cannabis Cannabinoid Res.2016 Jul 1;1(1):154-165. doi: 10.1089/can.2016.0009. eCollection 2016.
  2. Endocannabinoids in chronic migraine: CSF findings suggest a system failure.

Neuropsychopharmacology. 2007 Jun;32(6):1384-90. Epub 2006 Nov 22.

Sarchielli P et al.

  1. Beyond Cannabis: Plants and the Endocannabinoid System. Russo EB1.

Trends Pharmacol Sci. 2016 Jul;37(7):594-605. doi: 10.1016/ Epub 2016 May 11.


  2. Astrup T, et al: ‘Thromboplastic and Fibrinolytic Activity of the Human Aorta.‘ Circulation Research, Volume VII, November 1959.

Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks. Meng Qu, Tomas Duffy, Tsuyoshi Hirota, and Steve A. Kay. PNAS published ahead of print December 10, 2018

Oral Vitamin C (500 mg/day) to Pregnant Smokers Improves Infant Airway Function at 3 Months (VCSIP): A Randomized Trial.

McEvoy CT et al. Am J Respir Crit Care Med. 2018 Dec 7. doi: 10.1164/rccm.201805-1011OC. [Epub ahead of print].

Noah Snyder-Mackler, Joaquín Sanz, Jordan N. Kohn, Tawni Voyles, Roger Pique-Regi, Mark E. Wilson, Luis B. Barreiro, and Jenny Tung. Social status alters chromatin accessibility and the gene regulatory response to glucocorticoid stimulation in rhesus macaquesPNAS, 2018 DOI: 10.1073/pnas.1811758115.

December 2018


Estimation of global insulin use for type 2 diabetes, 2018–30: a microsimulation analysis. Sanjay Basu et al. The Lancet Diabetes & Endocrinology 2018. Published online Nov 20. DOI:

Expenditures and Prices of Antihyperglycemic Medications in the United States: 2002-2013. Xinyang Hua et al. JAMA. 2016;315(13):1400-1402. doi:10.1001/jama.2016.0126

Gonzalez, PS et al. Mannose impairs tumour growth and enhances chemotherapy. Nature 2018, Nov 21. DOI:

Carole A. Federico, Taiji Wang, Adélaïde Doussau, Jeffrey S. Mogil, Dean Fergusson, Jonathan Kimmelman. Assessment of Pregabalin Postapproval Trials and the Suggestion of Efficacy for New IndicationsJAMA Internal Medicine, 2018; DOI: 10.1001/jamainternmed.2018.5705.

Blue light exposure decreases systolic blood pressure, arterial stiffness, and improves endothelial function in humans. Manuel Stern et al. European Journal of Preventive Cardiology, 2018; 204748731880007 DOI: 10.1177/2047487318800072

BEN BROWN – Nature


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participating in physical activity in outdoor natural environments have a greater effect on physical and mental wellbeing than physical activity indoors? A systematic review. Environ Sci Technol. 2011 Mar 1;45(5):1761-72.

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  21. Diet-induced extinctions in the gut microbiota compound over generations.

Sonnenburg ED, Smits SA, Tikhonov M, Higginbottom SK, Wingreen NS, Sonnenburg JL. Nature 2016, Jan 14;529(7585):212-5

  1. Logan AC, Jacka FN, Prescott SL. Immune-Microbiota Interactions: Dysbiosis as a Global Health Issue. Curr Allergy Asthma Rep. 2016 Jan;16(2):13.

 NUTRIGENOMICS – Kara Fitzgerald

  1. Understanding the regulatory and transcriptional complexity of the genome through structure. Tim R. Mercer and John S. Mattick. Genome Res. 2013 Jul; 23(7): 1081–1088.

doi: 10.1101/gr.156612.113.

  1. Lobo, I. (2008) Epistasis: Gene interaction and the phenotypic expression of complex diseases like Alzheimer’s. Nature Education1(1):180.
  2. Major Heart Disease Genes Prove Elusive. Jennifer Couzin-Frankel. Science 04 Jun 2010: Vol. 328, Issue 5983, pp. 1220-21. DOI: 10.1126/science.328.5983.1220.
    4. The Elusive ALS Genes. Ken Garber. Science 04 Jan 2008: Vol. 319, Issue 5859, pp. 20
    DOI: 10.1126/science.319.5859.20.
    5. Genes and Autoimmune Diseases — A Complex Inheritance. Highlights of the 54th Annual Meeting of the American Society of Human Genetics; October 26-30, 2004; Toronto, Ontario, Canada. Sara M Mariani, PhD. MedGenMed. 2004; 6(4): 18.
  3. Combined effect of CYP1B1COMTGSTP1, and MnSODgenotypes and risk of postmenopausal breast cancer. J Gynecol Oncol. 2011 Jun 30; 22(2): 110–119.

doi: 10.3802/jgo.2011.22.2.110.

  1. Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Fredrick R. Schumacher et al. Nature Genetics, 2018, 50: 928–936.
  2. Heather M. Ochs-Balcom et al. Physical activity modifies genetic susceptibility to obesity in postmenopausal women. Menopause, 2018; 1 DOI: 10.1097/GME.0000000000001134.

Ossenkoppele R, Rabinovici GD, Smith R, et al. Discriminative Accuracy of [18F]flortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative Disorders. JAMA, 2018; 320 (11): 1151–1162 DOI: 10.1001/jama.2018.12917.

Adam P Spira, Yang An, Mark N Wu, Jocelynn T Owusu, Eleanor M Simonsick, Murat Bilgel, Luigi Ferrucci, Dean F Wong, Susan M Resnick. Excessive daytime sleepiness and napping in cognitively normal adults: associations with subsequent amyloid deposition measured by PiB PET. Sleep, 2018; DOI: 10.1093/sleep/zsy152.

Ross S. Mancini, Yanfei Wang, Donald F. Weaver. Phenylindanes in Brewed Coffee Inhibit Amyloid-Beta and Tau Aggregation. Frontiers in Neuroscience, 2018; 12 DOI: 10.3389/fnins.2018.00735.


Nutritional status, brain network organization, and general intelligence

Marta K.Zamroziewicz et al. NeuroImage, Volume 161, 1 November 2017, Pages 241-250.

Maternal Dietary Choline Status Influences Brain Gray and White Matter Development in Young Pigs. Austin T Mudd et al. Current Developments in Nutrition, 2: 6, 1 June 2018,


Makrides, L Duley, SF Olsen. Fish oil and other prostaglandin precursor supplementation during pregnancy for reducing pre-eclampsia, preterm birth, low birth weight and intrauterine growth restriction. Cochrane Review, 2018 DOI:

Long-term intake of vegetables and fruits and subjective cognitive function in US men.

Changzheng Yuan, Elinor Fondell, Ambika Bhushan, Alberto Ascherio, Olivia I. Okereke, Francine Grodstein, Walter C. Willett. Neurology 2018, first published Nov 21, 2018, DOI:

Angele M. De Silva, Rían W. Manville, Geoffrey W. Abbott. Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activationScience Advances, 2018; 4 (11): eaav0824 DOI: 10.1126/sciadv.aav0824

 Wahl D et al. Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice. Cell Rep. 2018 Nov 20;25(8):2234-2243.e6. doi: 10.1016/j.celrep.2018.10.070.

Salas-Huetos A et al. The Effect of Nutrients and Dietary Supplements on Sperm Quality Parameters: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Advances in Nutrition, 2018; 9(6), 833-848. DOI: 10.1093/advances/nmy057.

Calorie restriction
1.  Cash A. Oxaloacetic Acid Supplementation as a Mimetic of Calorie Restriction. Open Longevity Science. 2009;3:22-7.

  1. Williams DS, Cash A, Hamadani L, Diemer T. Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Aging Cell. 2009;8(6):765-8.
  2. Shintani H, Shintani T, Ashida H, Sato M. Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose Metabolism. Nutrients. 2018;10(12): open access at
  3. Lane, M.A; Ingram, D.K; Roth, G.S. 2-Deoxy-D-glucose feeding in rats mimics physiologic effects of calorie restriction. J. Anti Aging Med. 1998, 1, 327-337.

Gut-brain mechanism
1. Pellegrini C et al (2018) Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases? Acta Neuropathol 136:345. doi:10.1007/s00401-018-1856-5.

  1. Kaelberer et al (2018) A gut-brain neural circuit for nutrient sensory transduction. Science 361(6408):eaat5236. doi:10.1126/science.aat5236.
  2. Bohórquez and Liddle (2015) The gut connectome: making sense of what you eat. J Clin Invest125(3):888–890. doi:10.1172/JCI81121.


  1. Urolithin A induces mitophagy and prolongs lifespan in C. elegansand increases muscle function in rodents. Dongryeol Ryu et al. Nature Medicine 2016, 22: 879–88.
  2. Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials. Carine Dion, Eric Chappuis, and Christophe Ripoll. Nutr Metab (Lond) 2016, 13: 28, doi:  10.1186/s12986-016-0086-x.
November 2018


 Precision identification of diverse bloodstream pathogens in the gut microbiome. Tamburini FB, Andermann TM, Tkachenko E, Senchyna F, Banaei N, Bhatt AS. Nat Med. 2018 Oct 15. doi: 10.1038/s41591-018-0202-8.

Development of the Highly Processed Food Withdrawal Scale. Appetite 2018,

Vol 131, 1 December, 148-154.

Bruce N. Ames. Prolonging healthy ageing: Longevity vitamins and proteins, Proceedings of the National Academy of Sciences (2018). DOI: 10.1073/pnas.1809045115 

Bruce N. Ames. Low micronutrient intake may accelerate the degenerative diseases of ageing through allocation of scarce micronutrients by triage. PNAS November 21, 2006 103 (47) 17589-17594;


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  2. Da Costa K.A., Badea M., Fischer L.M., Zeisel S.H. Elevated serum creatine phosphokinase in choline-deficient humans: Mechanistic studies in C2C12 mouse myoblasts. Am. J. Clin. Nutr. 2004;80:163–170.
  3. Da Costa K.A., Niculescu M.D., Craciunescu C.N., Fischer L.M., Zeisel S.H. Choline deficiency increases lymphocyte apoptosis and DNA damage in humans. Am. J. Clin. Nutr. 2006;84:88–94.
  4. Zeisel SH, da Costa KA. Choline: an essential nutrient for public health. Nutr Rev. 2009 Nov;67(11):615-23.
  5. Bidulescu A, Chambless LE, Siega-Riz AM, Zeisel SH, Heiss G. Repeatability and measurement error in the assessment of choline and betaine dietary intake: the atherosclerosis risk in communities (ARIC) study. Nutr J 2009, 8(1): 14.
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  16. Zeisel SH. Nutrition in pregnancy: the argument for including a source of choline. Int J Womens Health. 2013 Apr 22;5:193-9.
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Mingfei Zhao, Brian W Whitcomb, Alexandra C Purdue-Smithe, JoAnn E Manson, Susan E Hankinson, Bernard A Rosner, Elizabeth R Bertone-Johnson. Physical activity is not related to risk of early menopause in a large prospective studyHuman Reproduction, 2018; DOI: 10.1093/humrep/dey267.

Yashvee Dunneram, Darren Charles Greenwood, Victoria J Burley, Janet E Cade. Dietary intake and age at natural menopause: results from the UK Women’s Cohort StudyJournal of Epidemiology and Community Health, 2018; DOI: 10.1136/jech-2017-209887

  1. Reduce hot flashes and other menopausal symptoms: a beneficial proprietary Siberian rhubarb root extract, Kristen Haabala, ND, and Mark Kaye, DC. Naturopathic Doctor News and Review, posted Dec 7, 2012:
    2. A Non-Hormone Approach to Menopause Management, by Stephanie Clark. Life Extension Magazine, October 2018.

Fiona S Atkinson, Dale Hancock, Peter Petocz, Jennie C Brand-Miller. The physiologic and phenotypic significance of variation in human amylase gene copy number. The American Journal of Clinical Nutrition, 2018; 108 (4): 737 DOI: 10.1093/ajcn/nqy164

  1. Falchi et al. Low copy number of the salivary amylase gene predisposes to obesity. Nature Genetics, 2014 DOI: 10.1038/ng.2939

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase. Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-018-06158-5.

Suleiman Furmli, Rami Elmasry, Megan Ramos, Jason Fung. Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulinBMJ Case Reports, 2018; bcr-2017-221854 DOI: 10.1136/bcr-2017-221854

White J, Xiong S, Malvin N, Khoury-Hanold W, Heuckeroth R, Stappenbeck T, Diamond MS. Intestinal dysmotility syndromes following system infection by flaviviruses. Cell. Oct, 4, 2018.


October 2018


Jørgensen L, Gøtzsche P, Jefferson T. The Cochrane HPV vaccine review was incomplete and ignored important evidence of bias. BMJ Evid Based Med 2018, Jul 27.
Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors. Cochrane Database Syst Rev2018;5:CD009069.pmid:29740819.

Index of the human papillomavirus (HPV) vaccine industry clinical study programmes and non-industry funded studies: a necessary basis to address reporting bias in a systematic review. Syst Rev 2018;7:8. doi:10.1186/s13643-018-0675-z pmid:29347995.

HPV vaccine safety: Cochrane launches urgent investigation into review after criticisms. BMJ 2018; 362 doi: (Published 09 August 2018).

Greenhalgh T, Howick J, Maskrey N; Evidence Based Medicine Renaissance Group. Evidence based medicine: a movement in crisis? BMJ. 2014 Jun 13;348:g3725. doi: 10.1136/bmj.g3725.

 Resveratrol Supplementation Reduces Pain and Inflammation in Knee Osteoarthritis Patients Treated with Meloxicam: A Randomized Placebo-Controlled Study. Published Online ahead of print Journal of Medicinal Food, August 30, 2018: (Free access to October 17.)

Cell 2018 Sep 6;174(6):1388-1405.e21. doi: 10.1016/j.cell.2018.08.041.

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A Phenome-Wide Association Study Uncovers a Role for Autoimmunity in the Development of Chronic Obstructive Pulmonary Disease. American Journal of Respiratory Cell and Molecular Biology, 2018; 58 (6): 777 DOI: 10.1165/rcmb.2017-0409LE

Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for β Cell Recovery. Cell Metabolism, 2018,

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Complementary Medicine, Refusal of Conventional Cancer Therapy, and Survival Among Patients With Curable Cancers

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Gut Microbiota Composition is Related to Cardiorespiratory Fitness in Healthy Young AdultsInternational Journal of Sport Nutrition and Exercise Metabolism, 2018; 1 DOI: 10.1123/ijsnem.2018-0024

Voluntary fortification is ineffective to maintain the vitamin B12 and folate status of older Irish adults: evidence from the Irish Longitudinal Study on Ageing (TILDA)British Journal of Nutrition, 2018; 120 (01): 111 DOI: 10.1017/S0007114518001356.

Continuity of care with doctors—a matter of life and death? A systematic review of continuity of care and mortality. BMJ Open, 8:6.

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Fecal Gluten Peptides Reveal Limitations of Serological Tests and Food Questionnaires for Monitoring Gluten-Free Diet in Celiac Disease Patients

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Occult blood in faeces is associated with all-cause and non-colorectal cancer mortalityGut, 2018; gutjnl-2018-316483 DOI: 10.1136/gutjnl-2018-316483

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Using citizen science to describe the prevalence and distribution of tick bite and exposure to tick-borne diseases in the United StatesPLOS ONE, 2018; 13 (7): e0199644 DOI: 10.1371/journal.pone.0199644

Dietary flavonoids and the prevalence and 15-y incidence of age-related macular degeneration. American Journal of Clinical Nutrition, 2018 DOI: 10.1093/ajcn/nqy114

Effects of an Antioxidant-enriched Multivitamin in Cystic Fibrosis: Randomized, Controlled, Multicenter Trial. American Journal of Respiratory and Critical Care Medicine, 2018; DOI: 10.1164/rccm.201801-0105OC

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124. Shishtar E, Sievenpiper JL, Djedovic V, Cozma AI, Ha V, Jayalath VH, Jenkins DJ, Meija SB, de Souza RJ, Jovanovski E, Vuksan V. The effect of ginseng (the genus panax) on glycemic control: a systematic review and meta-analysis of randomized controlled clinical trials. PLoS One. 2014 Sep 29;9(9):e107391.
125. Lee HW, Lim HJ, Jun JH, Choi J, Lee MS. Ginseng for Treating Hypertension: A Systematic Review and Meta-Analysis of Double Blind, Randomized, Placebo-Controlled Trials. Curr Vasc Pharmacol. 2017;15(6):549-556.
126. Jung DH, Lee YJ, Kim CB, Kim JY, Shin SH, Park JK. Effects of ginseng on peripheral blood mitochondrial DNA copy number and hormones in men with metabolic syndrome: A randomized clinical and pilot study. Complement Ther Med. 2016 Feb;24:40-6.
127. Pratte MA, Nanavati KB, Young V, Morley CP. An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). J Altern Complement Med. 2014 Dec;20(12):901-8.
128. Choudhary D, Bhattacharyya S, Joshi K. Bodyweight management in adults under chronic stress through treatment with Ashwagandha root extract: a double blind randomized, placebo controlled trial. J Evid based complementary altern med. 2017;22:96–106.

affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study. Journal of Affective Disorders, May 2018, 232, 349–357.


1. Akhondzaheh S, Tahmacebi-Pour N, Noorbala AA et al. Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial. Phytother Res 2005; 19(2): 148-151.
2. Moshiri E, Basti AA, Noorbala AA et al. Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: a double-blind, randomized and placebo-controlled trial. Phytomedicine 2006; 13(9-10): 607-611.
3. Akhondzadeh S, Fallah-Pour H, Afkham K et al. Comparison of Crocus sativus L and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial [ISRCTN45683816]. BMC Complement Altern Med 2004; 4: 12.
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5. Akhondzadeh Basti A, Moshiri E, Noorbala AA et al. Comparison of petal of Crocus sativus L and fluoxetine in the treatment of depressed outpatients: a pilot double-blind randomized trial. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31(2): 439-442
6. Modabbernia A, Sohrabi H, Nasehi AA et al. Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial. Psychopharmacology (Berl) 2012; 223(4): 381-388
7. Kashani L, Raisi F, Saroukhani S et al. Saffron for treatment of fluoxetine-induced sexual dysfunction in women: randomized double-blind placebo-controlled study. Hum Psychopharmacol 2012 [Epub ahead of print]
8. Lechtenberg M, Schepmann D, Niehues M et al. Quality and functionality of saffron: quality control, species assortment and affinity of extract and isolated saffron compounds to NMDA and sigma1 (sigma-1) receptors. Planta Med 2008; 74(7): 764-772
9. Berger F, Hensel A, Nieber K. Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices. Neuroscience 2011; 180: 238-247
10. Hosseinzadeh H, Sadeghnia HR. Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems. Phytomedicine 2007; 14(4): 256-26.
11. Sadeghnia HR, Cortez MA, Liu D et al. Antiabsence effects of safranal in acute experimental seizure models: EEG and autoradiography. J Pharm Pharm Sci 2008; 11(3): 1-14.

12. Akhondzadeh S, Shafiee Sabet M, Harirchian MH et al. A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer’s disease. Psychopharmacology (Berl) 2010; 207(4): 637-643
13. Akhondzadeh S, Sabet MS, Harirchian MH et al. Saffron in the treatment of patients with mild to moderate Alzheimer’s disease: a 16-week, randomized and placebo- controlled trial. J Clin Pharm Ther 2010; 35(5): 581-588
14. Agha-Hosseini M, Kashani L, Aleyaseen A et al. Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo- controlled trial. BJOG 2008; 115(4):

15. Nahid K, Fariborz M, Ataolah G et al. The effect of an Iranian herbal drug on primary dysmenorrhea: a clinical controlled trial. J Midwifery Womens Health 2009; 54(5):
16. Gout B, Bourges C, Paineau-Dubreuil S. Satiereal, a Crocus sativus L extract, reduces snacking and increases satiety in a randomized placebo-controlled study
of mildly overweight, healthy women. Nutr Res. 2010 May;30(5):305-13. doi: 10.1016/j.nutres.2010.04.008.
17. Falsini B, Piccardi M, Minnella A et al. Influence of saffron supplementation on retinal flicker sensitivity in early age-related macular degeneration. Invest Ophthalmol Vis Sci 2010; 51(12): 6118-6124
18. Professor Silvia Bisti. Researchers strike gold – saffron found to help vision loss in elderly. The University of Sydney News, 5 February 2010. au/news/84.html?newsstoryid=4452. Accessed January 2013.
19. Piccardi M, Marangoni D, Minnella AM et al. A longitudinal follow-up study of saffron supplementation in early age-related macular degeneration: sustained benefits to central retinal function. Evid Based Complement Alternat Med 2012; 2012: 429124


Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces. Nature Immunology, 2016; DOI: 10.1038/ni.3345


Miguel’s food challenge:

Harnessing the Power of Microbiome Assessment Tools as Part of Neuroprotective Nutrition and Lifestyle Medicine Interventions
by Miguel Toribio-Mateas. Microorganisms 2018, 6(2), 35;

American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems. 2018 May 15;3(3). pii: e00031-18. doi: 10.1128/mSystems.00031-18. eCollection 2018 May-Jun.

Martin, C. M. and Felix-Bortolotti, M. (2010) ‘W(h)ither complexity? The emperor’s new toolkit? Or elucidating the evolution of health systems knowledge?’, J Eval Clin
Pract, 16(3), pp. 415-20.

Daniel McDonald et al. American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems, 2018; 3 (3): e00031-18 DOI: 10.1128/mSystems.00031-18

Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth.
Probiotics Antimicrob Proteins. 2018 Mar 5. doi: 10.1007/s12602-018-9401-3. [Epub ahead of print]


CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system—New mode of action for caffeine. PLOS Biology, 2018; 16 (6): e2004408 DOI: 10.1371/journal.pbio.2004408

Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus. Neuron, 2018; DOI: 10.1016/j.neuron.2018.05.023

June 2018


Mediterranean diet and 3-year Alzheimer brain biomarker changes in middle-aged adults. Neurology. Online April 13, 2018, DOI:

Lifestyle and vascular risk effects on MRI-based biomarkers of Alzheimer’s disease: a cross-sectional study of middle-aged adults from the broader New York City area. BMJ Open. 2018 Mar 23;8(3):e019362. doi: 10.1136/bmjopen-2017-019362.

Counting the Cost:

Bernie Sanders opioid bill:

BEN BROWN – IBD interventions

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1. ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury. The American Journal of Gastroenterology, 2014; DOI: 10.1038/ajg.2014.131.
Bonkovsky also quoted in “When Green Tea Is a Bad Thing”, by Charlotte Hilton Andersen, SHAPE:
2. Determination of Catechin and Epicatechin Content in Chocolates by High-Performance Liquid Chromatography. Int Sch Res Notices. 2014; 2014: 628196. Published online 2014 Oct 28. doi:  10.1155/2014/628196.

  1. Green Tea Catechins and Cardiovascular Health: An Update. Curr Med Chem. 2008; 15(18): 1840–1850. Pon Velayutham, Anandh Babu, and Dongmin Liu.
  2. Suppressive Effects of Tea Catechins on Breast Cancer. Nutrients. 2016 Aug; 8(8): 458. Published online 2016 Jul 28. doi:  10.3390/nu8080458
  3. Green Tea Polyphenols Stimulate Mitochondrial Biogenesis and Improve Renal Function after Chronic Cyclosporin A Treatment in Rats. PLoS One. 2013; 8(6): e65029.

Published online 2013 Jun 3. doi:  10.1371/journal.pone.0065029

Blueberry Supplementation Influences the Gut Microbiota, Inflammation, and Insulin Resistance in High-Fat-Diet-Fed Rats. J Nutr. 2018 Feb 1;148(2):209-219. doi: 10.1093/jn/nxx027.

Diet-driven microbiota dysbiosis is associated with vagal remodeling and obesity. Physiology & Behavior, 2017; 173: 305 DOI: 10.1016/j.physbeh.2017.02.027

Oral NaHCO3 Activates a Splenic Anti-Inflammatory Pathway: Evidence That Cholinergic Signals Are Transmitted via Mesothelial Cells. The Journal of Immunology, 2018; ji1701605 DOI: 10.4049/jimmunol.1701605

Wax Esters from the Marine Copepod Calanus finmarchicus Reduce Diet-Induced Obesity and Obesity-Related Metabolic Disorders in Mice. J Nutr, 2013, doi: 10.3945/jn.113.182501.
Oil from the marine zooplankton Calanus finmarchicus improves the cardiometabolic phenotype of diet-induced obese mice. British Journal of Nutrition 2013, 110 (12): 2186-93.

Wax Esters from the Marine Copepod Calanus finmarchicus Reduce Diet-Induced Obesity and Obesity-Related Metabolic Disorders in Mice. J Nutr 2014, 144 (2): 164-169.

Extract from the Marine Copepod Calanus finmarchicus Attenuates Atherogenesis in Female Apolipoprotein E-Deficient Mice. J Nutr 2012, 142: 508-512.
Dietary and pharmacological anti-obesogenic treatments improve myocardial metabolism in diet-induced obese mice. Poster presented at 2017 Annual Scientific Sessions, Society for Heart and Vascular Metabolism. P2.11.


  1. Mushrooms: A rich source of the antioxidants ergothioneine and glutathione. Michael D. Kalaras, John P. Richie, Ana Calcagnotto, Robert B. Beelman.  Food Chemistry, 2017; 233: 429 DOI: 10.1016/j.foodchem.2017.04.109
  2. The Complexity of Fungal β-Glucan in Health and Disease: Effects on the Mononuclear Phagocyte System. Camilli G, Tabouret G, Quintin J. Front Immunol.2018 Apr 16;9:673. doi: 10.3389/fimmu.2018.00673. eCollection 2018.
  3. Anti-inflammatory properties of the medicinal mushroom Cordyceps militaris might be related to its linear (1→3)-β-D-glucan. PLoS One.2014 Oct 17;9(10):e110266. doi: 10.1371/journal.pone.0110266. eCollection 2014.
    4. β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance. Cell, 2016; 167 (5): 1354 DOI: 10.1016/j.cell.2016.09.034
  5. Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation. J Diet Suppl.2016 Jul 13:1-13. [Epub ahead of print]
  6. Edible and Medicinal Mushrooms: Emerging Brain Food for the Mitigation of Neurodegenerative Diseases. Journal of Medicinal FoodVOL. 20, NO. 1 |

Published Online: 1 Jan 2017

  1. Article online at MRL’s website:

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging. Cell Stem Cell, 2018; 22 (5): 769 DOI: 10.1016/j.stem.2018.04.001.

Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells. Cell Metab. 2016 Apr 12;23(4):663-74. doi: 10.1016/j.cmet.2016.03.001. Epub 2016 Mar 31.

Natural polyphenols as sirtuin 6 modulators. Scientific Reports, 2018; 8 (1) DOI: 10.1038/s41598-018-22388-5.

Inactive Matrix Gla Protein, Arterial Stiffness, and Endothelial Function in African American Hemodialysis Patients. American Journal of Hypertension, 2018; 31 (6): 735 DOI: 10.1093/ajh/hpy049.

Effect of a high-egg diet on cardiometabolic risk factors in people with type 2 diabetes: the Diabetes and Egg (DIABEGG) Study—randomized weight-loss and follow-up phase.  American J of Clinical Nutrition, 2018; DOI: 10.1093/ajcn/nqy048

Microglial control of astrocytes in response to microbial metabolites. Nature, 2018; DOI: 10.1038/s41586-018-0119-x

The mycobiome: Role in health and disease, and as a potential probiotic target in gastrointestinal disease. Dig Liver Dis. 2017 Nov;49(11):1171-1176. doi: 10.1016/j.dld.2017.08.025. Epub 2017 Oct 4.

Vitamin D Switches BAF Complexes to Protect β Cells. Cell, 2018; DOI: 10.1016/j.cell.2018.04.013.

May 2018

JAMA Intern Med. 2018 Jan 1;178(1):17-26. doi: 10.1001/jamainternmed.2017.5038.

Association Between Pesticide Residue Intake From Consumption of Fruits and Vegetables and Pregnancy Outcomes Among Women Undergoing Infertility Treatment With Assisted Reproductive Technology.

Chiu YH1,2Williams PL2,3Gillman MW4,5Gaskins AJ1,6Mínguez-Alarcón L7Souter I8Toth TL8Ford JB7Hauser R2,7,8Chavarro JE1,2,6EARTH Study Team.

Hum Reprod. 2015 Jun;30(6):1342-51. doi: 10.1093/humrep/dev064. Epub 2015 Mar 30. Fruit and vegetable intake and their pesticide residues in relation to semen quality among men from a fertility clinic.

Chiu YH1Afeiche MC2Gaskins AJ3Williams PL4Petrozza JC5Tanrikut C6Hauser R7Chavarro JE8.

CNN Exclusive: “The more opioids doctors prescribe, the more money they make”

Story by Aaron KesslerElizabeth Cohen and Katherine Grise. Updated 8:45 AM ET, Mon March 12, 2018:

Jonathan C Hill, David GT Whitehurst, Martyn Lewis, Stirling Bryan, Kate M Dunn, Nadine E Foster, Kika Konstantinou, Chris J Main, Elizabeth Mason, Simon Somerville, Gail Sowden, Kanchan Vohora, Elaine M Hay. Comparison of stratified primary care management for low back pain with current best practice (STarT Back): a randomised controlled trial. The Lancet, 2011; 378 (9802): 1560 DOI: 10.1016/S0140-6736(11)60937-9

What low back pain is and why we need to pay attention. Jan Hartvigsen, Mark J Hancock, Alice Kongsted, Quinette Louw, Manuela L Ferreira, Stéphane Genevay, Damian Hoy, Jaro Karppinen, Glenn Pransky, Joachim Sieper, Rob J Smeets, Martin Underwood on behalf of the Lancet Low Back Pain Series Working Group

The Lancet, March 21, 2018.

Eva Benito, Cemil Kerimoglu, Binu Ramachandran, Tonatiuh Pena-Centeno, Gaurav Jain, Roman Manuel Stilling, Md Rezaul Islam, Vincenzo Capece, Qihui Zhou, Dieter Edbauer, Camin Dean, André Fischer. RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental EnrichmentCell Reports, 2018; 23 (2): 546 DOI: 10.1016/j.celrep.2018.03.059.


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  4. Nogueira, L., Acute Oxaloacetate Exposure Enhances Resistance to Fatigue in in vitro Mouse Soleus Muscle. FASEB Journal, 2011. 25(1104.5).

Christopher R. Martens, Blair A. Denman, Melissa R. Mazzo, Michael L. Armstrong,

Nichole Reisdorph, Matthew B. Mcqueen, Michel Chonchol, Douglas R. Seals. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD in healthy middle-aged and older adultsNature Communications, 2018; DOI: 10.1038/s41467-018-03421-7.

Hypertension – BEN BROWN

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  43. Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial. Phytother Res. 2018 Feb 22. doi: 10.1002/ptr.6046. [Epub ahead of print]
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 Toxins – Dr BEN LYNCH

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Evidence-Based Medicine – Dr JASON FUNG

  1. N Engl J Med.2007 Apr 12;356(15):1503-16. Epub 2007 Mar 26.

Optimal medical therapy with or without PCI for stable coronary disease.

Boden WE1O’Rourke RATeo KKHartigan PMMaron DJKostuk WJKnudtson MDada MCasperson PHarris CLChaitman BRShaw LGosselin GNawaz STitle LMGau GBlaustein ASBooth DCBates ERSpertus JABerman DSMancini GBWeintraub WSCOURAGE Trial Research Group.

  1. Lancet.2018 Jan 6;391(10115):31-40. doi: 10.1016/S0140-6736(17)32714-9. Epub 2017 Nov 2.

Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial.

Al-Lamee R1Thompson D1Dehbi HM2Sen S1Tang K3Davies J3Keeble T3Mielewczik M4Kaprielian R5Malik IS5Nijjer SS5Petraco R1Cook C1Ahmad Y1Howard J1Baker C5Sharp A6Gerber R7Talwar S8Assomull R5Mayet J1Wensel R4Collier D9Shun-Shin M1Thom SA1Davies JE10Francis DP1ORBITA investigators.

  1. Offline: What is medicine’s 5 sigma?

Richard Horton. The Lancet, 11 April 2015. DOI:

  1. Drug Companies & Doctors: A Story of Corruption

Marcia Angell. New York Review of Books, Jan 15, 2009.

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America’s other drug problem: how the drug industry distorts medicine and politics. Relman AS, Angell M.

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Selective publication of antidepressant trials and its influence on apparent efficacy. Turner EH, Matthews AM, Linardatos E, Tell RA, Rosenthal R.

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Editors, Publishers, Impact Factors, and Reprint Income. Harvey Marcovitch.

  1. Payments by US pharmaceutical and medical device manufacturers to US medical journal editors: retrospective observational study. BMJ2017; 359 doi: 26 October 2017).
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Association between industry affiliation and position on cardiovascular risk with rosiglitazone: cross sectional systematic review. Wang AT1McCoy CPMurad MHMontori VM.


  4. Lactate metabolism: historical context, prior misinterpretations, and current understanding. Brian S. Ferguson, Matthew J. Rogatzki, Matthew L. Goodwin, Daniel A. Kane, Zachary Rightmire, L. Bruce Gladden. European Journal of Applied Physiology. Published online Jan 2018.
  5. Exercise-Induced Inflammatory Response: To Use or Not use Anti-Inflammatory Medication. Albená Nunes-Silva. Journal of Sports Medicine & Doping Studies 2014, 4:142. doi: 10.4172/2161-0673.1000142. Experimental Gerontology, Volume 69, September 2015, Pages 159-169.
  6. Exp Gerontol.2015 Sep;69:159-69. A standardized randomized 6-month aerobic exercise-training down-regulated pro-inflammatory genes, but up-regulated anti-inflammatory, neuron survival and axon growth-related genes.

Iyalomhe O1Chen Y2Allard J3Ntekim O4Johnson S3Bond V1Goerlitz D5Li J5Obisesan TO6.

  1. “Chapter 7 – Supplemental Antioxidants and Adaptation to Physical Training”,

Micah Gross and Oliver Baum in Antioxidants in Sport Nutrition, Lamprecht M, editor.

Boca Raton (FL): CRC Press/Taylor & Francis; 2015.

  2. Phys Sportsmed.2014 Sep;42(3):45-52. doi: 10.3810/psm.2014.09.2075.

Validation of musculoskeletal ultrasound to assess and quantify muscle glycogen content. A novel approach. Hill JC1Millán IS.

  1. J Acad Nutr Diet.2016 Mar;116(3):501-528. doi: 10.1016/j.jand.2015.12.006.

Position of the Academy of Nutrition and Dietetics, Dietitians of Canada, and the American College of Sports Medicine: Nutrition and Athletic Performance.

Thomas DT1Erdman KA2Burke LM3.

  1. Eur J Appl Physiol.2017 Feb;117(2):247-254. doi: 10.1007/s00421-016-3512-x. Epub 2016 Dec 24. Cardiovascular function during supine rest in endurance-trained males with New Zealand blackcurrant: a dose-response study.

Cook MD1Myers SD1Gault ML1Edwards VC1Willems ME2.
12. Int J Sport Nutr Exerc Metab. 2015 Aug;25(4):367-74. doi: 10.1123/ijsnem.2014-0233. Epub 2015 Mar 26. Beneficial Physiological Effects With Blackcurrant Intake in Endurance Athletes. Willems ME1Myers SDGault MLCook MD.

  1. Adv Ther.2011 Dec;28(12):1078-88. doi: 10.1007/s12325-011-0083-4. Epub 2011 Nov 24. A new ginkgo fresh plant extract increases microcirculation and radical scavenging activity in elderly patients. Suter A1Niemer WKlopp R.
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    16. Int J Sport Nutr Exerc Metab.2013 Apr;23(2):161-9. Epub 2012 Dec 7.

Effects of DHA-rich fish oil supplementation on lymphocyte function before and after a marathon race.

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  1. Influence of a montmorency cherry juice blend on indices of exercise-induced stress and upper respiratory tract symptoms following marathon running—a pilot investigation. Lygeri Dimitriou,Jessica A HillAhmed JehnaliJoe DunbarJames BrounerMalachy P. McHugh, and Glyn Howatson. J Int Soc Sports Nutr. 2015; 12: 22.

Published online 2015 May 11. doi:  10.1186/s12970-015-0085-8.

  1. McNaughton, L, Bentley, D and Koeppel, P, The effects of a nucleotide supplement on the immune and metabolic response to short term, high intensity exercise performance in trained male subjects. J Sports Med Phys Fitness46: 112-118, 2007.
    19. Ostojic, SM and Obrenovic, M. Sublingual nucleotides and immune response to exercise. J IntSoc Sports Nutr 9: 31, 2012.
  2. Asian Journal of Pharmaceutical Sciences. Volume 12, Issue 3, May 2017, Pages 209-215. The role of serratiopeptidase in the resolution of inflammation. Review.


  1. J Clin Exp Dent.2015 Apr 1;7(2):e197-202. doi: 10.4317/jced.51868. eCollection 2015 Apr. Comparison of clinical efficacy of methylprednisolone and serratiopeptidase for reduction of postoperative sequelae after lower third molar surgery. Chappi D M1Suresh KV2Patil MR3Desai R4Tauro DP5Bharani K N S S6Parkar MI7Babaji HV8.
  2. J Maxillofac Oral Surg.2018 Jun;17(2):122-128. doi: 10.1007/s12663-017-0996-9. Epub 2017 Jan 18. Role of Serratiopeptidase After Surgical Removal of Impacted Molar: A Systematic Review and Meta-analysis. Sivaramakrishnan G1Sridharan K2.
April 2018

The epidemiology of multimorbidity in primary care: a retrospective cohort study. Anna Cassell, Duncan Edwards, Amelia Harshfield, Kirsty Rhodes, James Brimicombe, Rupert Payne and Simon Griffin. British Journal of General Practice 12 March 2018


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50.  Safar ME. Arterial stiffness as a risk factor for clinical hypertension. Nat Rev Cardiol. 2018 Feb;15(2):97-105.51.  Jamwal S, Sharma S. Vascular endothelium dysfunction: a conservative target in metabolic disorders. Inflamm Res. 2018 Jan 25. doi: 10.1007/s00011-018-1129-8.52.  Castro-Ferreira R, Cardoso R, Leite-Moreira A, Mansilha A. The Role of Endothelial Dysfunction and Inflammation in Chronic Venous Disease. Ann Vasc Surg. 2018 Jan;46:380-393.53.  Bruno RM, Masi S, Taddei M, Taddei S, Virdis A. Essential Hypertension and Functional Microvascular Ageing. High Blood Press Cardiovasc Prev. 2018 Mar;25(1):35-40.54.  Macready AL, George TW, Chong MF, Alimbetov DS, Jin Y, Vidal A, Spencer JP, Kennedy OB, Tuohy KM, Minihane AM, Gordon MH, Lovegrove JA; FLAVURS Study Group.  Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease–FLAVURS: a randomized controlled trial. Am J Clin Nutr. 2014 Mar;99(3):479-89.55.  John JH, Ziebland S, Yudkin P, Roe LS, Neil HA; Oxford Fruit and Vegetable Study Group. Effects of fruit and vegetable consumption on plasma antioxidant concentrations and blood pressure: a randomised controlled trial. Lancet. 2002 Jun 8;359(9322):1969-74.56.  Varadharaj S, Kelly OJ, Khayat RN, Kumar PS, Ahmed N, Zweier JL. Role of Dietary Antioxidants in the Preservation of Vascular Function and the Modulation  of Health and Disease. Front Cardiovasc Med. 2017 Nov 1;4:64.57.  Machha A, Schechter AN. Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits. Eur J Nutr. 2011 Aug;50(5):293-303.58.  d’El-Rei J, Cunha AR, Trindade M, Neves MF. Beneficial Effects of Dietary Nitrate on Endothelial Function and Blood Pressure Levels. Int J Hypertens. 2016;2016:6791519.

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CONSULTATION – Garner Thomson

1. Beckman HB, Frankel RM (1984) The effect of physician behavior on the collection of data. Annals of Internal Medicine 101:692-6

2. Marvel MK (1999) Soliciting the patient’s agenda: have we improved? JAMA; 281: 283–7.


3. Svab I (1993) The time used by the patient when he/she talks without interruptions. Aten Primaria; 11: 175–7


4. Little M (1995) Humane Medicine. Cambridge:Cambridge University Press


5. Thomson G, Khan K (2016) Magic in Practice, London:Hammersmith Health Books


6.Hagger, M. S., Koch, S., Chatzisarantis, N. L. D., & Orbell, S. (2017). The common sense model of self-regulation: Meta-analysis and test of a process model. Psychological Bulletin, 143(11), 1117-1154.



Hetland G, Johnson E, Lyberg T, Kvalheim G (2011) The mushroom AgaricusblazeiMurill elicits medicinal effects on tumor, infection, allergy, and inflammation through its modulation of innate immunity and amelioration of Th1/Th2 imbalance and inflammation. Advances in PharmacologicalSciences, Article ID 157015.

Kohda H, Tokumoto W, Sakamoto K, Fujii M, Hirai Y, Yamasaki K, Komoda Y, Nakamura H, Ishihara S, Uchida M (1985). The biologically active constituents of Ganodermalucidum (Fr.) Karst histamine release-inhibitory triterpenes. Chemical and PharmaceuticalBulletin 33, 1367-1374.

Powell M (2006) The use of Ganodermalucidum (Reishi) in the management of histamine-mediated allergic responses Townsend Letter. TheExaminer of Alternative Medicine 274, 26-30

Takimoto H, Kato H, Kaneko M, Kumazawa Y (2008) Amelioration of skewed Th1/Th2 balance in tumor-bearing and asthma-induced mice by oral administration of Agaricusblazei extracts. Immunopharmacology and Immunotoxicology 30, 747-760

Tasaka K, Akagi M, Miyoshi K, Mio M, Makino T (1988a) Anti-allergic constituents in the culture medium of Ganodermalucidum. (I) Inhibitory effect of oleic acid on histamine release. Agents Actions 23,153-156

Tasaka K, Mio M, Izushi K, Akagi M, Makino T (1988b) Anti-allergic constituents in the culture medium of Ganodermalucidum. (II) The inhibitory effect of cyclooctasulfur on histamine release. Agents Actions 23, 157-160

Milica Vukmanovic-Stejic, Emma S. Chambers, Mayte Suárez-Fariñas, Daisy Sandhu, Judilyn Fuentes-Duculan, Neil Patel, Elaine Agius, Katie E. Lacy, Carolin T. Turner, Anis Larbi, Veronique Birault, Mahdad Noursadeghi, Neil A. Mabbott, Malcolm H.A. Rustin, James G. Krueger, Arne N. Akbar. Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase–induced inflammationJournal of Allergy and Clinical Immunology, 2017; DOI: 10.1016/j.jaci.2017.10.032


Leanne M. Redman, Steven R. Smith, Jeffrey H. Burton, Corby K. Martin, Dora Il’yasova, Eric Ravussin. Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of AgingCell Metabolism, 2018; DOI: 10.1016/j.cmet.2018.02.019

  1. Parvez, R. R. Gerona, C. Proctor, M. Friesen, J. L. Ashby, J. L. Reiter, Z. Lui, P. D. Winchester. Glyphosate exposure in pregnancy and shortened gestational length: a prospective Indiana birth cohort studyEnvironmental Health, 2018; 17 (1) DOI: 10.1186/s12940-018-0367-0

Erzsebet Polyak, Julian Ostrovsky, Min Peng, Stephen D. Dingley, Mai Tsukikawa, Young Joon Kwon, Shana E. McCormack, Michael Bennett, Rui Xiao, Christoph Seiler, Zhe Zhang, Marni J. Falk. N -acetylcysteine and vitamin E rescue animal longevity and cellular oxidative stress in pre-clinical models of mitochondrial complex I disease. Molecular Genetics and Metabolism, 2018; DOI: 10.1016/j.ymgme.2018.02.013

Eneida Boteon Schmitt, Jorge Nahas-Neto, Flavia Bueloni-Dias, Priscila Ferreira Poloni, Claudio Lera Orsatti, Eliana Aguiar Petri Nahas. Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women. Maturitas, 2018; 107: 97 DOI: 10.1016/j.maturitas.2017.10.011

Smruti Pushalkar, Mautin Hundeyin, Donnele Daley, Constantinos P. Zambirinis, Emma Kurz, Ankita Mishra, Navyatha Mohan, Berk Aykut, Mykhaylo Usyk, Luisana E. Torres, Gregor Werba, Kevin Zhang, Yuqi Guo, Qianhao Li, Neha Akkad, Sarah Lall, Benjamin Wadowski, Johana Gutierrez, Juan Andres Kochen Rossi, Jeremy W. Herzog, Brian Diskin, Alejandro Torres-Hernandez, Josh Leinwand, Wei Wang, Pardeep S. Taunk, Shivraj Savadkar, Malvin Janal, Anjana Saxena, Xin Li, Deirdre Cohen, R. Balfour Sartor, Deepak Saxena, George Miller. The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune SuppressionCancer Discovery, 2018; DOI: 10.1158/2159-8290.CD-17-1134

Brandon H Hidaka, Jocelynn M Thodosoff, Elizabeth H Kerling, Holly R Hull, John Colombo, Susan E Carlson. Intrauterine DHA exposure and child body composition at 5 y: exploratory analysis of a randomized controlled trial of prenatal DHA supplementation. The American Journal of Clinical Nutrition, 2018; 107 (1): 35 DOI: 10.1093/ajcn/nqx007

Current Opinion in Food Science, Volume 20, April 2018, Pages 19-23. CYP7A1-rs3808607: a single nucleotide polymorphism associated with cholesterol response to functional foods YongboShe12Dylan SMacKay23James DHouse2Peter JHJones.

COMMENT by Dr Eve Pearce:

Abdullah, M. M., Cyr, A., Lépine, M.-C., Eck, P. K., Couture, P., Lamarche, B., & Jones, P. J. (2016). Common Variants in Cholesterol Synthesis– and Transport–Related Genes Associate with Circulating Cholesterol Responses to Intakes of Conventional Dairy Products in Healthy Individuals. The Journal of Nutrition, 146(5), 1008–1016.

De Castro-Orós, I., Pampín, S., Cofán, M., Mozas, P., Pintó, X., Salas-Salvadó, J., … Pocoví, M. (2011). Promoter variant −204A > C of the cholesterol 7α-hydroxylase gene: Association with response to plant sterols in humans and increased transcriptional activity in transfected HepG2 cells. Clinical Nutrition, 30(2), 239–246.

Jenkins, D. J. A., Kendall, C. W. C., Faulkner, D., Vidgen, E., Trautwein, E. A., Parker, T. L., … Connelly, P. W. (2002). A dietary portfolio approach to cholesterol reduction: combined effects of plant sterols, vegetable proteins, and viscous fibers in hypercholesterolemia. Metabolism: Clinical and Experimental, 51(12), 1596–604.

Juzyszyn, Z., Kurzawski, M., Lener, A., Modrzejewski, A., Pawlik, A., & Droździk, M. (2008). Cholesterol 7α-Hydrolase ( CYP7A1 ) c.−278A>C Promoter Polymorphism in Gallstone Disease Patients. Genetic Testing, 12(1), 97–100.

MacKay, D. S., Eck, P. K., Gebauer, S. K., Baer, D. J., & Jones, P. J. (2015). CYP7A1-rs3808607 and APOE isoform associate with LDL cholesterol lowering after plant sterol consumption in a randomized clinical trial. The American Journal of Clinical Nutrition, 102(4), 951–957.

Rideout, T. C., Harding, S. V, & Mackay, D. S. (2012). Metabolic and genetic factors modulating subject specific LDL-C responses to plant sterol therapy. Canadian Journal of Physiology and Pharmacology, 90(5), 509–14.

Russell, D. W. (2003). The enzymes, regulation, and genetics of bile acid synthesis. Annual Review of Biochemistry, 72(1), 137–74.

She, Y., MacKay, D. S., House, J. D., & Jones, P. J. (2018). CYP7A1-rs3808607: a single nucleotide polymorphism associated with cholesterol response to functional foods. Current Opinion in Food Science, 20, 19–23.




March 2018

IHCAN March references


Fiolet Thibault, Srour Bernard, Sellem Laury, Kesse-Guyot Emmanuelle, Allès Benjamin, Méjean Caroline et al. Consumption of ultra-processed foods and cancer risk: results from NutriNet-Santé prospective cohort. BMJ 2018; 360 :k322.

Yumi Hurst, Haruhisa Fukuda. Effects of changes in eating speed on obesity in patients with diabetes: a secondary analysis of longitudinal health check-up data. BMJ Open, 2018; 8 (1): e019589 DOI: 10.1136/bmjopen-2017-019589.

Christopher D. Gardner, John F. Trepanowski, Liana C. Del Gobbo, Michelle E. Hauser, Joseph Rigdon, John P. A. Ioannidis, Manisha Desai, Abby C. King. Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical TrialJAMA, 2018; 319 (7): 667-679 DOI: 10.1001/jama.2018.0245.

Adelaida Esteban-Fernández, Irene Zorraquín-Peña, Maria D. Ferrer, Alex Mira, Begoña Bartolomé, Dolores González de Llano, M. Victoria Moreno-Arribas. Inhibition of Oral Pathogens Adhesion to Human Gingival Fibroblasts by Wine Polyphenols Alone and in Combination with an Oral ProbioticJournal of Agricultural and Food Chemistry, 2018; DOI: 10.1021/acs.jafc.7b05466


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MUSHROOM NUTRITION1             American Chemical Society (2000, May 12). New Evidence Found Linking Herpes and Alzheimer’s. Science Daily. Retrieved July 26, 2013, from http://             University of Manchester (2008, December 7). Cold Sore Virus Linked To Alzheimer’s Disease: New Treatment, Or Even Vaccine Possible. Science- Daily. Retrieved July 26, 2013, from /releas- es/2008/12/081207134109.htm3             MA Wozniak, AP Mee and RF Itzhaki. Herpes simplex virus type I DNA is located within Alzheimer’s disease amyloid plaques. The Journal of Pathology, Volume 217, Issue 1 , Pages131 – 138 2009 DOI: 10.1002/path.24494             Carter CJ. Alzheimer´s disease plaques and tangles:cemeteries of phyrrhic victory of the immune defence network against herpes simplex infection at the expense of complement and inflammation-mediated neuronal destruction.Neurochem Int. 2011 Feb 58(3):301-20 doi 10 1016/j.neuint 2010.12.20.003Epub 2010 Dec 15.5             Wozniak MA, Frost AL, Preston CM, Itzhaki RF.  Antivirals reduce the forma- tion of key Alzheimer´s disease molecules in cell cultures acutely infected with herpes simplex virus type 1. PLoS One. 2011:6(10) e25152 doi 10 1371/ journal. pone.0025152. EPUB 2011 Oct 7.6             Pandley JP. Immunoglobulin GM genese as functional risk and protective fac- tors for the development of Alzheimer´s disease. J. Alzheimers Dis 2009;17(4) 753-6 doi 10.3222/JAD-2009-1094.7             Wozniak MA, Itzhaki RF. Intravenous immounoglobulin reduces amyloid and abnormal tau formation caused by herpes simplex virus type 1. J Neuroimmunol 2013 Apr 15:257 (1-2):7-12 doi 10. 1016/ jnmeuroim 2013.01.005 Epub 2013Feb 4.8             Medeiros R, Kitazawa M, Passos GF, Baglietto-Vargas D, Cheng D, Cribbs  OH, LaFerla FM. Aspirin-triggered  lipoxin  A4  stimulates  alternative  activation of microglia and reduces Alzheimer disease-like pathology in mice. Am J Pathol. 2013 May, 182(5);1740-9 ..9             Jean A. Monro, Chronic Fatigue Immune Dysfunction Syndrome. J Integrative Medicine 2004; 8:101-10810           Jean A. Monro. Treatment of Cancer with Mushroom Products. Arch Env Health 2003;58:533-537.11           Silva Couto J, Pereira da Silva D. Evaluation of the Efficacy of Coriolus versicolor Supplementation in HPV Lesions (LSIL) . Poster presented at the 20th European Congress of Obstetrics and Gynecology, Lisbon, Portugal March4-8th, 2008.12           Cornelius C. , Cavallaro M., Cambria M.T., Toscano M.A., Calabrese V. Com- parative Enzyme Analysis of Polyporus umbellatus, Agaricus blazei, Pleurotus osteratus and Hericium erinaceus . Clinical Journal of Mycology 2009 Vol II Page 4 to 7.13           Kulmann I, Minihane Am, Huebbe P, Nebel A , Rimbach G. Apolipoprotien  E genotype and hepatitis c, HIV and herpes simplex diseae risk: a literature review. Lipids Health Dis. 2010 Jan 28.9.8 doi 10.1186/1476-511-9.614           Miklossy J. Emerging roles of pathogens in Alzheimer disease. Expert Rev Mol Med. 2011 Sept 20; 13 e 30 doi 10 1017/S14623994 1 1002006.  Also relevant:
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Attia Anwar, Provvidenza Maria Abruzzo, Sabah Pasha, Kashif Rajpoot, Alessandra Bolotta, Alessandro Ghezzo, Marina Marini, Annio Posar, Paola Visconti, Paul J. Thornalley, Naila Rabbani. Advanced glycation endproducts, dityrosine and arginine transporter dysfunction in autism – a source of biomarkers for clinical diagnosisMolecular Autism, 2018; 9 (1) DOI: 10.1186/s13229-017-0183-3.


Kathleen F. Holton, Peter K. Ndege, Daniel J. Clauw. Dietary correlates of chronic widespread pain in meru, KenyaNutrition, 2018; DOI: 10.1016/j.nut.2018.01.016.

Adil Mardinoglu, Hao Wu, Elias Bjornson, Cheng Zhang, Antti Hakkarainen, Sari M. Räsänen, Sunjae Lee, Rosellina M. Mancina, Mattias Bergentall, Kirsi H. Pietiläinen, Sanni Söderlund, Niina Matikainen, Marcus Ståhlman, Per-Olof Bergh, Martin Adiels, Brian D. Piening, Marit Granér, Nina Lundbom, Kevin J. Williams, Stefano Romeo, Jens Nielsen, Michael Snyder, Mathias Uhlén, Göran Bergström, Rosie Perkins, Hanns-Ulrich Marschall, Fredrik Bäckhed, Marja-Riitta Taskinen, Jan Borén. An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans. Cell Metabolism, 2018; DOI: 10.1016/j.cmet.2018.01.005.

Nicola McCleary, Bright I. Nwaru, Ulugbek B. Nurmatov, Hilary Critchley, Aziz Sheikh. Endogenous and exogenous sex steroid hormones in asthma and allergy in females: A systematic review and meta-analysisJournal of Allergy and Clinical Immunology, 2018; DOI: 10.1016/j.jaci.2017.11.034



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Woodcock B A, Ridding L, Freeman S N, Pereira M G, Sleep D, Redhead J, et al. (2018) Neonicotinoid residues in UK honey despite European Union moratorium. DOI: 10.1371/journal.pone.0189681 (open access)

Katarina Ondrusova, Mohammad Fatehi, Amy Barr, Zofia Czarnecka, Wentong Long, Kunimasa Suzuki, Scott Campbell, Koenraad Philippaert, Matthew Hubert, Edward Tredget, Peter Kwan, Nicolas Touret, Martin Wabitsch, Kevin Y. Lee, Peter E. Light. Subcutaneous white adipocytes express a light sensitive signaling pathway mediated via a melanopsin/TRPC channel axisScientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-16689-4

Anas Raed, Jigar Bhagatwala, Haidong Zhu, Norman K. Pollock, Samip J. Parikh, Ying Huang, Robyn Havens, Ishita Kotak, De-Huang Guo, Yanbin Dong. Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial. PLOS ONE, 2017; 12 (12): e0188424 DOI: 10.1371/journal.pone.0188424


Infectious virus in exhaled breath of symptomatic seasonal influenza cases from a college community. PNAS 2018 ; published ahead of print January 18, 2018, doi:10.1073/pnas.1716561115. 

Enhanced aerobic exercise performance in women by a combination of three mineral Chelates plus two conditionally essential nutrients

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Kourosh Kalantar-Zadeh, Kyle J. Berean, Nam Ha, Adam F. Chrimes, Kai Xu, Danilla Grando, Jian Zhen Ou, Naresh Pillai, Jos L. Campbell, Robert Brkljača, Kirstin M. Taylor, Rebecca E. Burgell, Chu K. Yao, Stephanie A. Ward, Chris S. McSweeney, Jane G. Muir, Peter R. Gibson. A human pilot trial of ingestible electronic capsules capable of sensing different gases in the gutNature Electronics, 2018; 1 (1): 79 DOI: 10.1038/s41928-017-0004-x.

Paleo diet: material supplied by Umeå universitet: – dissertation available there.

Stephen A. Fleming, Supida Monaikul, Alexander J. Patsavas, Rosaline V. Waworuntu, Brian M. Berg, Ryan N. Dilger. Dietary polydextrose and galactooligosaccharide increase exploratory behavior, improve recognition memory, and alter neurochemistry in the young pigNutritional Neuroscience, 2017; 1 DOI: 10.1080/1028415X.2017.1415280.

Giuseppe Faraco, David Brea, Lidia Garcia-Bonilla, Gang Wang, Gianfranco Racchumi, Haejoo Chang, Izaskun Buendia, Monica M. Santisteban, Steven G. Segarra, Kenzo Koizumi, Yukio Sugiyama, Michelle Murphy, Henning Voss, Joseph Anrather, Costantino Iadecola. Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 responseNature Neuroscience, 2018; DOI: 10.1038/s41593-017-0059-z

Salt stats:

Irina Leonardi et al. CX3CR1 mononuclear phagocytes control immunity to intestinal fungiScience, 2018 DOI: 10.1126/science.aao1503.

Sébastien Lucas, Yasunori Omata, Jörg Hofmann, Martin Böttcher, Aida Iljazovic, Kerstin Sarter, Olivia Albrecht, Oscar Schulz, Brenda Krishnacoumar, Gerhard Krönke, Martin Herrmann, Dimitrios Mougiakakos, Till Strowig, Georg Schett, Mario M. Zaiss. Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-017-02490-4


Yu-Jin Jung, Young-Tae Lee, Vu Le Ngo, Young-Hee Cho, Eun-Ju Ko, Sung-Moon Hong, Ki-Hye Kim, Ji-Hun Jang, Joon-Suk Oh, Min-Kyung Park, Cheol-Hyun Kim, Jun Sun, Sang-Moo Kang. Heat-killed Lactobacillus casei confers broad protection against influenza A virus primary infection and develops heterosubtypic immunity against future secondary infectionScientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-17487-8

Aura Raulo, Lasse Ruokolainen, Avery Lane, Katherine Amato, Rob Knight, Steven Leigh, Rebecca Stumpf, Bryan White, Karen E. Nelson, Andrea L. Baden, Stacey R. Tecot. Social behaviour and gut microbiota in red-bellied lemurs (Eulemur rubriventer): In search of the role of immunity in the evolution of socialityJournal of Animal Ecology, 2017; DOI: 10.1111/1365-2656.12781

Corticotropin-releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress-induced pathophysiology.

Ayyadurai S, Gibson AJ, D’Costa S, Overman EL, Sommerville LJ, Poopal AC, Mackey E, Li Y, Moeser AJ. J Leukoc Biol. 2017 Dec;102(6):1299-1312. doi: 10.1189/jlb.2HI0317-088RR.

Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide.

Gulledge TV1, Collette NM1, Mackey E2, Johnstone SE1, Moazami Y3, Todd DA4, Moeser AJ2, Pierce JG5, Cech NB4, Laster SM6. J Ethnopharmacol. 2018 Feb 15;212:166-174. doi: 10.1016/j.jep.2017.10.012. Epub 2017 Oct 14.

Evilena Anastasiou, Anastasia Papathanasiou, Lynne A. Schepartz, Piers D. Mitchell. Infectious disease in the ancient Aegean: Intestinal parasitic worms in the Neolithic to Roman Period inhabitants of Kea, GreeceJournal of Archaeological Science: Reports, 2017; DOI: 10.1016/j.jasrep.2017.11.006

Catherine Vilchèze, John Kim, William R. Jacobs. Vitamin C potentiates the killing of Mycobacterium tuberculosis by the first-line tuberculosis drugs isoniazid and rifampicin in miceAntimicrobial Agents and Chemotherapy, 2018; AAC.02165-17 DOI: 10.1128/AAC.02165-17

January 2018


Lean, Michael EJ et al. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. The Lancet, 5 December 2017. DOI:

Elisabetta Lauretti, Domenico Pratic�. Effect of canola oil consumption on memory, synapse and neuropathology in the triple transgenic mouse model of Alzheimer’s diseaseScientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-17373-3

Monica E. Embers, Nicole R. Hasenkampf, Mary B. Jacobs, Amanda C. Tardo, Lara A. Doyle-Meyers, Mario T. Philipp, Emir Hodzic. Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feedingPLOS ONE, 2017; 12 (12): e0189071 DOI: 10.1371/journal.pone.0189071

Nicholas A. Crossland, Xavier Alvarez, Monica E. Embers. Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Post-Treatment in Rhesus MacaquesThe American Journal of Pathology, 2017; DOI: 10.1016/j.ajpath.2017.11.005

J Public Health Policy. 2017 Nov 27. doi: 10.1057/s41271-017-0095-7. [Epub ahead of print]. Complexity and conflicts of interest statements: a case-study of emails exchanged between Coca-Cola and the principal investigators of the International Study of Childhood Obesity, Lifestyle and the Environment (ISCOLE).

Stuckler D1, Ruskin G2, McKee M3. Open Access:


Louisa E. Jeffery, Peter Henley, Nefisa Marium, Andrew Filer, David M. Sansom, Martin Hewison, Karim Raza. Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid jointJournal of Autoimmunity, 2017; DOI: 10.1016/j.jaut.2017.10.001

Shweta Khanna, Kumar Sagar Jaiswal, Bhawna Gupta. Managing Rheumatoid Arthritis with Dietary InterventionsFrontiers in Nutrition, 2017; 4 DOI: 10.3389/fnut.2017.00052

  1. Loukov, S. Karampatos, M.R. Maly, D.M.E. Bowdish. Monocyte activation is elevated in women with knee-osteoarthritis and associated with inflammation, BMI and painOsteoarthritis and Cartilage, 2017; DOI: 10.1016/j.joca.2017.10.018

Diddier Prada, Jia Zhong, Elena Colicino, Antonella Zanobetti, Joel Schwartz, Nicholas Dagincourt, Shona C Fang, Itai Kloog, Joseph M Zmuda, Michael Holick, Luis A Herrera, Lifang Hou, Francesca Dominici, Benedetta Bartali, Andrea A Baccarelli. Association of air particulate pollution with bone loss over time and bone fracture risk: analysis of data from two independent studiesThe Lancet Planetary Health, 2017; 1 (8): e337 DOI: 10.1016/S2542-5196(17)30136-5

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3503-3508. doi: 10.1073/pnas.1618545114. Epub 2017 Mar 13.

B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial.

Zhong J1, Karlsson O2,3, Wang G4, Li J5,6, Guo Y7, Lin X8, Zemplenyi M7, Sanchez-Guerra M9, Trevisi L10, Urch B11,12,13,14, Speck M11, Liang L7, Coull BA7, Koutrakis P10, Silverman F11,12,13,14, Gold DR10,15, Wu T5,6, Baccarelli AA16.

A.A. Macintosh et al. Prehistoric women’s manual labor exceeded that of athletes through the first 5500 years of farming in Central EuropeScience Advances, 2017 DOI: 10.1126/sciadv.aao3893


Omar Al Rifai, Jacqueline Chow, Julie Lacombe, Catherine Julien, Denis Faubert, Delia Susan-Resiga, Rachid Essalmani, John W.M. Creemers, Nabil G. Seidah, Mathieu Ferron. Proprotein convertase furin regulates osteocalcin and bone endocrine functionJournal of Clinical Investigation, 2017; 127 (11): 4104 DOI: 10.1172/JCI93437

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PMCID: PMC4611080. Yogurt drink fortified with menaquinone-7 improves vitamin K status in a healthy population

Marjo H. J. Knapen,1 Lavienja A. J. L. M. Braam,1 Kirsten J. Teunissen,1 Renate M. L. Zwijsen,2 Elke Theuwissen,1 andCees Vermeer1,*

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16. Guowei Dai, Tiantong Bao, Changfu Xu, Raymond Cooper, and Jia-Shi Zhu. CordyMax™ Cs-4 Improves Steady-State Bioenergy Status in Mouse Liver.
JACM 2004, July, 7(3): 231-240.
17. Holm JE, Lamberty K, McSherry WC 2nd, Davis PA The stress response in headache sufferers: physiological and psychological reactivity. Headache 1997, Apr;37(4):221-7.
18. Fukui PT et al. Trigger factors in migraine patients. Arq Neuropsiquiatr 2008, Sep; 66(3A):494-9.
19. Sun T-F et al. Mindfulness meditation in the control of severe headache. Chang Gung Med J, 2002, 25, 8.
20. Yi Liu, Jihui Wang. The Chemical Constituents and Pharmacological Actions of Cordyceps sinensis. Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 575063,
21. Nagano et al.. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Research 2010, 31, 231-237.
22. Lee J. M, Kwon H, Jeong H, editors. et al. Inhibition of lipid peroxidation and oxidative DNA damage by Ganoderma lucidum. Phytother Res 2001, 15:245–9.
23. Ji DB et al. Phytother Res 2009, Jan, 23(1):116-22. doi: 10.1002/ptr.2576.
Antiaging effect of Cordyceps sinensis extract.
24. Dancey CP, Taghavi M, Fox RJ. The relationship between daily stress and symptoms of irritable bowel: a time-series approach. J Psychosom Res 1998, May;44(5):537-45.
25. Shaw G et al. Stress management for irritable bowel syndrome: a controlled trial.
Digestion. 1991;50(1):36-42.
26. Koh J. H, Suh H. J, Ahn T. Hot-water extract from mycelia of Cordyceps sinensis as a substitute for antibiotic growth promoters. Biotechnol Lett 2003a, 25:585–90.
27. Macpherson AJ, Marrinic MM, Harris N. The functions of mucosal T-cells in containing the indigenous commensal flora of the intestine. Cell Mol Life Sci 2002, 59:2088–96.

NUTRIGENOMICS – Bernie Williams
I. Hara K et al., The Pro12Ala Polymorphism in PPAR𝛾2 may confer resistance to type 2 diabetes. Biochem Biophys. Res. Comm. (2000) 29:212-216
II. Stefan N. et al., Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 gene. Diabetes. (2001) 50:1143–1148
III. Vaquero AR et al. Using gene-network landscape to dissect genotype effects of TCF7L2 genetic variant on diabetes and cardiovascular risk. Physiol. Genomics. (2012) 44:903–14
IV. Shaffer S A et al. Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 gene polymorphisms. Diabetes. (2007)12: 2443-50
V. Grant S et al. Variant of Transcription factor 7-like 2 gene confers risk of type 2 diabetes. Nature. (2006) 38: 320-323
VI. Scheller J et al., The pro-and-anti-inflammatory properties of the cytokine interleukin-6. Biochim et Biophys Acta – Mol Cell Res. (2011) 1813:5 878-888
VII. Ligthart S et al., DNA methylation signatures of chronic low grade inflammation are associated with complex diseases. (2016) Genome Biology 17:255
VIII. Brustolin S et al., Genetics of homocysteine metabolism and associated disorders. Braz J Med Biol Res (2010) 43:1-7
IX. Lim U & Song M, Dietary and Lifestyle Factors of DNA methylation. Cancer Epigenetics (2012) 863:359-376
X. Bokor S et al., Single nucleotide polymorphism in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios. Journal of Lipid Research (2010) 51:2325-33.
XI. Vessby B et al,. Desaturation and elongation of Fatty acids and insulin action. Ann N Y Acad Sci. (2002) 967:183-95.
XII. Leffler D et al., Extraintestinal manifestations of coeliac disease. Nat. Rev. Gastroenterol.Hepatol. (2015) 12: 561-571
XIII. Monsuur et al., Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms. PLoS ONE. (2008) 3:e2270
XIV. Withoff S, et al., Understanding celiac disease by genomics. Trends in Genetics. (2016) 32:295-308.

FRONTIERS – Simon Mills
Aggarwal BB.(2004) Nuclear factor-kappaB: the enemy within. Cancer Cell 6(3): 203-208.
Barnard RJ, Aronson WJ. (2009) Benign prostatic hyperplasia: does lifestyle play a role? Phys Sportsmed 37(4): 141-146.
Barry MJ, Meleth S, Lee JY, et al (2011). Effect of increasing doses of saw palmetto extract on lower urinary tract symptoms: a randomized trial. Complementary and Alternative Medicine for Urological Symptoms (CAMUS) Study Group. JAMA. 306(12):1344-51.
Bombardelli E, Morazzoni P. (1997) Cucurbita pepo L. Fitoterapia 68(4): 291-302.
Bone K, Mills S. (2013) Principles and Practice of Phytotherapy; 2nd Edition. Churchill Livingstone, Edinburgh
Capodice JL, Gorroochurn P, Cammack S et al. (2009) Zyflamend in men with high-grade prostatic intraepithelial neoplasia: results of a phase I clinical trial. J Soc Integr Oncol 7(2): 43-51.
Demark-Wahnefried W, Polascik TJ, George SL et al. (2008) Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery. Cancer Epidemiol Biomarkers Prev 17(12): 3577-3587.
Freedland SJ, Aronson WJ. (2009) Dietary intervention strategies to modulate prostate cancer risk and prognosis. Curr Opin Urol 19(3): 263-267.
Gardner CD, Oelrich B, Liu JP et al. (2009) Prostatic soy isoflavone concentrations exceed serum levels after dietary supplementation. Prostate 69(7): 719-726.
Jacobs EJ, Rodriguez C, Mondul AM et al. (2005) A large cohort study of aspirin and other nonsteroidal anti-inflammatory drugs and prostate cancer incidence. J Natl Cancer Inst 97(13): 975-980.
John H, Barghorn A, Funke G et al. (2001) Noninflammatory chronic pelvic pain syndrome: immunological study in blood, ejaculate and prostate tissue. Eur Urol 39(1): 72-78.
Kell JS. (2010) Prostate-specific antigen tests and prostate cancer screening: an update for primary care physicians. Can J Urol 17(Suppl 1): 18-25.
Kramer G, Mitteregger D, Marberger M (2007). Is benign prostatic hyperplasia (BPH) an immune inflammatory disease? Eur Urol 51(5): 1202-1216.
Krieger JN. (2004) Classification, epidemiology and implications of chronic prostatitis in North America, Europe and Asia. Minerva Urol Nefrol 56(2): 99-107.
McCann MJ, Gill CI, Linton T et al. (2008) Enterolactone restricts the proliferation of the LNCaP human prostate cancer cell line in vitro. Mol Nutr Food Res 52(5): 567-580.
Mehik A, Hellstrom P, Sarpola A et al. (2001) Fears, sexual disturbances and personality features in men with prostatitis: a population-based cross-sectional study in Finland. BJU Int 88(1): g35-38.
Mills S. (2001) Benign prostatic disease: herbal approaches in Boyd & Hamilton-Stewart eds. Key advances in the effective management of benign prostatic disease. Journal of the Royal Society of Medicine, London. 35-40
Moul S, McVary KT. (2010) Lower urinary tract symptoms, obesity and the metabolic syndrome. Curr Opin Urol 20(1): 7-12.
Parsons JK, Im R. (2009) Alcohol consumption is associated with a decreased risk of benign prostatic hyperplasia. J Urol 182(4): 1463-1468.
Parsons JK, Sarma AV, McVary K et al. (2009) Obesity and benign prostatic hyperplasia: clinical connections, emerging etiological paradigms and future directions. J Urol 182(6 Suppl): S27-S31.
Parsons JK. (2007) Modifiable risk factors for benign prostatic hyperplasia and lower urinary tract symptoms: new approaches to old problems. J Urol 178(2): 395-401.
Patel AR, Klein EA. (2009) Risk factors for prostate cancer. Nat Clin Pract Urology 6(2): 87-95.
Ranjan P, Dalela D, Sankhwar SN. (2006) Diet and benign prostatic hyperplasia: implications for prevention. Urology 68(3): 470-476.
Roehrbornb CG (2008). Pathology of benign prostatic hyperplasia. Int J Impot Res 20(Suppl 3): S11-S18.
Safarinejad MR. (2005) Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. J Herbal Pharmacother 5(4): 1-11.
Sarma AV, Kellogg Parsons J. (2009) Diabetes and benign prostatic hyperplasia: emerging clinical connections. Curr Urol Rep 10(4): 267-275.
Sarma AV, Parsons JK, McVary K et al. (2009) Diabetes and benign prostatic hyperplasia/lower urinary tract symptoms-what do we know? J Urol 182(6 Suppl): S32-S37.
Schoonen WM, Salinas CA, Kiemeney LALM et al. (2005) Alcohol consumption and risk of prostate cancer in middle-aged men. Int J Cancer 113(1): 133-140.
Sciarra A, Mariotti G, Salciccia S et al. (2008) Prostate growth and inflammation. J Steroid Biochem Mol Biol 108(3-5): 254-260.
Sea J, Poon KS, McVary KT. (2009) Review of exercise and the risk of benign prostatic hyperplasia. Phys Sportsmed 37(4): 75-83.
Singh RP, Tyagi AK, Dhanalakshmi S et al. (2004) Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3. Int J Cancer 108(5): 733-740.
Tacklind J, MacDonald R, Rutks I, Wilt TJ. (2009) Serenoa repens for benign prostatic hyperplasia. Cochrane Database Syst Rev. CD001423.
Van Patten CL, de Boer JG, Tomlinson Guns ES. (2008) Diet and dietary supplement intervention trials for the prevention of prostate cancer recurrence: a review of the randomized controlled trial evidence. J Urol 180(6): 2314-2322.
Vikram A, Jena G, Ramarao P. (2010) Insulin-resistance and benign prostatic hyperplasia: the connection. Eur J Pharmacol 641(2-3): 75-81.
Wilt T, Ishani A, MacDonald R. (2002) Serenoa repens for benign prostatic hyperplasia. Cochrane Database Syst Rev CD001423.
Yan L, Spitznagel EL. (2009) Soy consumption and prostate cancer risk in men: a revisit of a meta-analysis. Am J Clin Nutr 89(4): 1155-1163.
Yassin AA, El-Sakka AI, Saad F et al. (2008) Lower urinary-tract symptoms and testosterone in elderly men. World J Urol 26(4): 359-364.

IN PRACTICE – Daniela Lawler.

Atkinson, W et al 2004. Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial. Gut, 53 Pp: 1391-1393.
Cantorna, M. Mahon, B. 2004. Mounting Evidence for Vitamin D as an Environmental Factor Affecting Autoimmune Disease Prevalence. EBM, 229(11).
Heitzer, T et al 2001. Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients with Coronary Artery Disease. Circulation, 104 Pp: 2673-2678. June 2017.
Hyde, J. (2015). The Gut Makeover. (Great Britain. Quercus).
Kharrazian, D (2010). Why Do I Still Have Thyroid Symptoms?. (California. Elephant Press) p25, 31.
Lewis, C. (2016). Enteroimmunology. 3rd ed (Carrabelle Florida. PsyPress), p246.
Liblau, R. 1995. Th1 and Th2 CD4+ T cells in the pathogenesis of organ specific autoimmune disease. Immunology Today, 16(1). Pp: 34-38.


Chunxu Gao, Bhanu Priya Ganesh, Zhongcheng Shi, Rajesh Rasik Shah, Robert Fultz, Angela Major, Susan Venable, Monica Lugo, Kathleen Hoch, Xiaowei Chen, Anthony Haag, Timothy C. Wang, James Versalovic. Gut Microbe–Mediated Suppression of Inflammation-Associated Colon Carcinogenesis by Luminal Histamine Production. The American Journal of Pathology, 2017; DOI: 10.1016/j.ajpath.2017.06.011

Lori D’Ortenzio, Isabelle Ribot, Bonnie Kahlon, Benoit Bertrand, Emmy Bocaege, Emeline Raguin, Annabelle Schattmann, Megan Brickley. The rachitic tooth: The use of radiographs as a screening technique. International Journal of Paleopathology, 2017; DOI: 10.1016/j.ijpp.2017.10.001

Haris Majeed, G. W. K. Moore. Impact of Multidecadal Climate Variability on United Kingdom Rickets Rates. Scientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-16058-1
Francesca Romana Mancini, Aurélie Affret, Courtney Dow, Beverley Balkau, Fabrice Bonnet, Marie-Christine Boutron-Ruault, Guy Fagherazzi. Dietary antioxidant capacity and risk of type 2 diabetes in the large prospective E3N-EPIC cohort. Diabetologia, 2017; DOI: 10.1007/s00125-017-4489-7

Nicola Wilck et al. Salt-responsive gut commensal modulates TH17 axis and disease. Nature, 2017; DOI: 10.1038/nature24628

November 2017

Joseph Jamnik, Christopher R Villa, Sirbarinder Bryn Dhir, David J A Jenkins, Ahmed El-Sohemy. Prevalence of positive coeliac disease serology and HLA risk genotypes in a multiethnic population of adults in Canada: a cross-sectional study. BMJ Open, 2017; 7 (10): bmjopen-2017-017678 DOI: 10.1136/bmjopen-2017-017678.

Luke T. Stewart, Anas U. Khan, Kai Wang, Diana Pizarro, Sandipan Pati, Susan C. Buckingham, Michelle L. Olsen, John C. Chatham, Lori L. McMahon. Acute Increases in Protein O-GlcNAcylation Dampen Epileptiform Activity in Hippocampus. The Journal of Neuroscience, 2017; 37 (34): 8207 DOI: 10.1523/JNEUROSCI.0173-16.2017.

Ken-ichi Kudo, Tadashi Hanafusa and Toshiro Ono.  In vitro analysis of radioprotective effect of monoterpenes. J Radioanal Nucl Chem (2017) 313: 169.

Laura M. Kemppainen, Teemu T. Kemppainen, Jutta A. Reippainen, Suvi T. Salmenniemi, Pia H. Vuolanto. Use of complementary and alternative medicine in Europe: Health-related and sociodemographic determinants. Scandinavian Journal of Public Health, 2017; 140349481773386 DOI: 10.1177/1403494817733869.

Olga Bednarska, Susanna A. Walter, Maite Casado-Bedmar, Magnus Ström, Eloísa Salvo-Romero, Maria Vicario, Emeran A. Mayer, Åsa V Keita. VIP and Mast Cells Regulate Increased Passage of Colonic Bacteria in Patients With Irritable Bowel Syndrome. Gastroenterology, 2017; DOI: 10.1053/j.gastro.2017.06.051

BEN BROWN – Nickel

1.             Schram SE, Warshaw EM, Laumann A. Nickel hypersensitivity: a clinical review and call to action. Int J Dermatol. 2010 Feb;49(2):115-25.2.             Yoshihisa Y, Shimizu T. Metal allergy and systemic contact dermatitis: an overview. Dermatol Res Pract. 2012;2012:749561.3.             Torres F, das Graças M, Melo M, Tosti A. Management of contact dermatitis due to nickel allergy: an update. Clin Cosmet Investig Dermatol. 2009 Apr 17;2:39-48.4.             Sharma AD. Relationship between nickel allergy and diet. Indian J Dermatol Venereol Leprol. 2007 Sep-Oct;73(5):307-12.5.             Jensen CS, Menné T, Lisby S, Kristiansen J, Veien NK. Experimental systemic contact dermatitis from nickel: a dose-response study. Contact Dermatitis. 2003 Sep;49(3):124-32.6.             Ysart G, Miller P, Crews H, Robb P, Baxter M, De L’Argy C, Lofthouse S, Sargent C, Harrison N. Dietary exposure estimates of 30 elements from the UK Total Diet Study. Food Addit Contam. 1999 Sep;16(9):391-403. 7.             Krecisz B, Chomiczewska D, Kiec-Swierczynska M, Kaszuba A. Systemic contact dermatitis to nickel present in cocoa in 14-year-old boy. Pediatr Dermatol. 2011 May-Jun;28(3):335-6. 8.             Silvestri DL, Barmettler S. Pruritus ani as a manifestation of systemic contact dermatitis: resolution with dietary nickel restriction. Dermatitis. 2011  Jan-Feb;22(1):50-5.

  1. Rizzi A, Nucera E, Laterza L, et al. Irritable Bowel Syndrome and Nickel Allergy: What Is the Role of the Low Nickel Diet? J Neurogastroenterol Motil. 2017 Jan 30;23(1):101-108.

10.         Sharma AD. Relationship between nickel allergy and diet. Indian J Dermatol Venereol Leprol. 2007 Sep-Oct;73(5):307-12.11.         Saito M, Arakaki R, Yamada A, Tsunematsu T, Kudo Y, Ishimaru N. Molecular Mechanisms of Nickel Allergy. Int J Mol Sci. 2016 Feb 2;17(2).12.         Minelli M, Schiavino D, Musca F, et al. Oral hyposensitization to nickel induces clinical improvement and a decrease in TH1 and TH2 cytokines in patients with systemic nickel allergy syndrome. Int J Immunopathol Pharmacol. 2010 Jan-Mar;23(1):193-201.

  1. Picarelli A, Di Tola M, Vallecoccia A, Libanori V, Magrelli M, Carlesimo M, et al. Oral mucosa patch test: a new tool to recognize and study the adverse effects of dietary nickel exposure. Biol Trace Elem Res 2011; 139: 151-9.

14.         Braga M, Quecchia C, Perotta C, Timpini A, Maccarinelli K, Di Tommaso L, Di Gioacchino M. Systemic nickel allergy syndrome: nosologic framework and usefulness of diet regimen for diagnosis. Int J Immunopathol Pharmacol. 2013 Jul-Sep;26(3):707-16.15.         Borghini R, Donato G, Alvaro D, Picarelli A. New insights in IBS-like disorders: Pandora’s box has been opened; a review. Gastroenterol Hepatol Bed Bench. 2017 Spring;10(2):79-89.

  1. Tammaro A, De Marco G, Persechino S, Narcisi A, Camplone G. Allergy to nickel: first results on patients administered with an oral hyposensitization therapy. Int J Immunopathol Pharmacol. 2009 Jul-Sep;22(3):837-40.


Roopa Hebbandi Nanjundappa, Francesca Ronchi, Jinguo Wang, Xavier Clemente-Casares, Jun Yamanouchi, Channakeshava Sokke Umeshappa, Yang Yang, Jesús Blanco, Helena Bassolas-Molina, Azucena Salas, Hamza Khan, Robyn M. Slattery, Madeleine Wyss, Catherine Mooser, Andrew J. Macpherson, Laura K. Sycuro, Pau Serra, Derek M. McKay, Kathy D. McCoy, Pere Santamaria. A Gut Microbial Mimic that Hijacks Diabetogenic Autoreactivity to Suppress Colitis. Cell, 2017; 171 (3): 655 DOI: 10.1016/j.cell.2017.09.022

Membrane Lipid Replacement – Mike Ash
[i] Nicolson GL, Ash ME.  Membrane Lipid Replacement for chronic illnesses, aging and cancer using oral glycerolphospholipid formulations with fructooligosaccharides to restore phospholipid function in cellular membranes, organelles, cells and tissues. Biochim. Biophys. Acta  2017; 1859: 1704-1724.  View Full Paper
[ii] Nicolson GL.  Membrane Lipid Replacement: clinical studies using a natural medicine approach to restoring membrane function and improving health.  Intern. J. Clin. Med. 2016; 7: 133-143. View Full Paper
[iii] Nicolson GL, Rosenblatt S, Ferreira de Mattos G, Settineri R, Breeding PC, Ellithorpe RR,  Ash ME.  Clinical uses of Membrane Lipid Replacement supplements in restoring membrane function and reducing fatigue in chronic diseases and cancer.  Discoveries 2016; 4(1): e54. View Full Paper
[iv] Singer, SJ, Nicolson GL The fluid mosaic model of the structure of cell membranes, Science 1972; 175: 720-731. View Abstract
[v] Nicolson GL. The Fluid—Mosaic Model of Membrane Structure: still relevant to understanding the structure, function and dynamics of biological membranes after more than 40 years. Biochim. Biophys. Acta 2014; 1838: 1451-1466. View Full Paper

Rosshart et al. Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance. Cell, 2017 DOI: 10.1016/j.cell.2017.09.016.

Troy D. Hubbard, Iain A. Murray, Robert G. Nichols, Kaitlyn Cassel, Michael Podolsky, Guray Kuzu, Yuan Tian, Phillip Smith, Mary J. Kennett, Andrew D. Patterson, Gary H. Perdew. Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner. Journal of Functional Foods, 2017; 37: 685 DOI: 10.1016/j.jff.2017.08.038.

Christopher L. Hager, Mahmoud A. Ghannoum. The mycobiome: Role in health and disease, and as a potential probiotic target in gastrointestinal disease. Digestive and Liver Disease, 2017; DOI: 10.1016/j.dld.2017.08.025.

Tiffani Alvey Jones, Diane Z. Hernandez, Zoë C. Wong, Anica M. Wandler, Karen Guillemin. The bacterial virulence factor CagA induces microbial dysbiosis that contributes to excessive epithelial cell proliferation in the Drosophila gut. PLOS Pathogens, 2017; 13 (10): e1006631 DOI: 10.1371/journal.ppat.1006631


Dorothy K. Sit, James McGowan, Christopher Wiltrout, Rasim Somer Diler, John (Jesse) Dills, James Luther, Amy Yang, Jody D. Ciolino, Howard Seltman, Stephen R. Wisniewski, Michael Terman, Katherine L. Wisner. Adjunctive Bright Light Therapy for Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Trial. American Journal of Psychiatry, 2017; appi.ajp.2017.1 DOI: 10.1176/appi.ajp.2017.16101200

Xiangyun Zhu et al. Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis. Nutrition & Metabolism 2017,14:60.

Kootte et al. Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition. Cell Metabolism, 2017 DOI: 10.1016/j.cmet.2017.09.008

Katherine McGuire, J.Antonio Avina-Zubieta, John M. Esdaile, Mohsen Sadatsafavi, Eric C. Sayre, Michal Abrahamowicz, Diane Lacaille. Risk of Incident Chronic Obstructive Pulmonary Disease (COPD) in Rheumatoid Arthritis: A Population Based Cohort Study. Arthritis Care & Research, 2017; DOI: 10.1002/acr.23410.

Ian J. Wallace et al. Knee osteoarthritis has doubled in prevalence since the mid-20th century PNAS 2017 114 (35) 9332-9336; doi:10.1073/pnas.1703856114

Timothy Heisel, Emmanuel Montassier, Abigail Johnson, Gabriel Al-Ghalith, Yi-Wei Lin, Li-Na Wei, Dan Knights, Cheryl A. Gale. High-Fat Diet Changes Fungal Microbiomes and Interkingdom Relationships in the Murine Gut. mSphere, October 2017 DOI: 10.1128/mSphere.00351-17.

Wendy S White, Yang Zhou, Agatha Crane, Philip Dixon, Frits Quadt, Leonard M Flendrig. Modeling the dose effects of soybean oil in salad dressing on carotenoid and fat-soluble vitamin bioavailability in salad vegetables. The American Journal of Clinical Nutrition, 2017; 106 (4): 1041 DOI: 10.3945/%u200Bajcn.117.153635

October 2017

IHCAN October references


Nisha Rao, Henry A. Spiller, Nichole L. Hodges, Thiphalak Chounthirath, Marcel J. Casavant, Amrit K. Kamboj, Gary A. Smith. An Increase in Dietary Supplement Exposures Reported to US Poison Control Centers. Journal of Medical Toxicology, 2017; DOI: 10.1007/s13181-017-0623-7.

Crawley EM, Gaunt DM, Garfield K, et al. Clinical and cost-effectiveness of the Lightning Process in addition to specialist medical care for paediatric chronic fatigue syndrome: randomised controlled trial. Archives of Disease in Childhood. Published Online First: 20 September 2017. doi: 10.1136/archdischild-2017-313375.

Chunxu Gao, Bhanu Priya Ganesh, Zhongcheng Shi, Rajesh Rasik Shah, Robert Fultz, Angela Major, Susan Venable, Monica Lugo, Kathleen Hoch, Xiaowei Chen, Anthony Haag, Timothy C. Wang, James Versalovic. Gut Microbe–Mediated Suppression of Inflammation-Associated Colon Carcinogenesis by Luminal Histamine Production. The American Journal of Pathology, 2017; DOI: 10.1016/j.ajpath.2017.06.011

NEW RELEASES – migraine

Lidiane Lima Florencio, Anamaria Siriani de Oliveira, Gabriela Ferreira Carvalho, Fabiola Dach, Marcelo Eduardo Bigal, César Fernández-de-las-Peñas, Débora Bevilaqua-Grossi. Association Between Severity of Temporomandibular Disorders and the Frequency of Headache Attacks in Women With Migraine: A Cross-Sectional Study. Journal of Manipulative and Physiological Therapeutics, 2017; 40 (4): 250 DOI: 10.1016/j.jmpt.2017.02.006.

BEN BROWN: Alzheimer’s


1.             Beilharz JE, Maniam J, Morris MJ. Diet-Induced Cognitive Deficits: The Role of Fat and Sugar, Potential Mechanisms and Nutritional Interventions. Nutrients. 2015 Aug 12;7(8):6719-38.2.             Petersson SD, Philippou E. Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence. Adv Nutr. 2016 Sep 15;7(5):889-904.3.             McMillan L, Owen L, Kras M, Scholey A. Behavioural effects of a 10-day Mediterranean diet. Results from a pilot study evaluating mood and cognitive performance. Appetite. 2011 Feb;56(1):143-7.

  1. Smith PJ, Blumenthal JA, Babyak MA, Craighead L, Welsh- Bohmer KA, Browndyke JN, et al. Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure. Hypertension 2010;55:1331–8.

5.             Martínez-Lapiscina EH, Clavero P, Toledo E, Estruch R, Salas-Salvadó J, San Julián B, Sanchez-Tainta A, Ros E, Valls-Pedret C, Martinez-Gonzalez MÁ. Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomized trial. J Neurol Neurosurg Psychiatry. 2013 Dec;84(12):1318-25.6.             Valls-Pedret C, Sala-Vila A, Serra-Mir M, Corella D, de la Torre R, Martínez-González MÁ, Martínez-Lapiscina EH, Fitó M, Pérez-Heras A, Salas-Salvadó J, Estruch R, Ros E. Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial. JAMA Intern Med. 2015 Jul;175(7):1094-103.7.             Knight A, Bryan J, Wilson C, Hodgson JM, Davis CR, Murphy KJ. The Mediterranean Diet and Cognitive Function among Healthy Older Adults in a 6-Month Randomised Controlled Trial: The MedLey Study. Nutrients. 2016 Sep 20;8(9).8.             Morris MC, Tangney CC, Wang Y, Sacks FM, Barnes LL, Bennett DA, Aggarwal NT. MIND diet slows cognitive decline with aging. Alzheimers Dement. 2015 Sep;11(9):1015-22.9.             Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT. MIND diet associated with reduced incidence of Alzheimer’s disease. Alzheimers Dement. 2015 Sep;11(9):1007-14.

  1. Morris MC. MIND Diet Intervention and Cognitive Decline (MIND). Accessed on on September 15th, 2017.

11.         Bland J. Mild Cognitive Impairment, Neurodegeneration, and Personalized Lifestyle Medicine. Integr Med (Encinitas). 2016 Apr;15(2):12-4.12.         Schelke MW, Hackett K, Chen JL, Shih C, Shum J, Montgomery ME, Chiang GC, Berkowitz C, Seifan A, Krikorian R, Isaacson RS. Nutritional interventions for Alzheimer’s prevention: a clinical precision medicine approach. Ann N Y Acad Sci. 2016 Mar;1367(1):50-6.13.         Bredesen DE. Reversal of cognitive decline: a novel therapeutic program. Aging (Albany NY). 2014 Sep;6(9):707-17. 14.         Bredesen DE, Amos EC, Canick J, Ackerley M, Raji C, Fiala M, Ahdidan J. Reversal of cognitive decline in Alzheimer’s disease. Aging (Albany NY). 2016 Jun;8(6):1250-8.15.         Koppel SJ, Swerdlow RH. Neuroketotherapeutics: A modern review of a century-old therapy. Neurochem Int. 2017 Jun 1. pii: S0197-0186(17)30227-9.16.         Cunnane SC, Courchesne-Loyer A, St-Pierre V, Vandenberghe C, Pierotti T, Fortier M, Croteau E, Castellano CA. Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer’s disease. Ann N Y Acad Sci. 2016 Mar;1367(1):12-20.17.         Yin JX, Maalouf M, Han P, Zhao M, Gao M, Dharshaun T, Ryan C, Whitelegge J, Wu J, Eisenberg D, Reiman EM, Schweizer FE, Shi J. Ketones block amyloid entry and improve cognition in an Alzheimer’s model. Neurobiol Aging. 2016 Mar;39:25-37.18.         Bough KJ, Wetherington J, Hassel B, Pare JF, Gawryluk JW, Greene JG, Shaw R, Smith Y, Geiger JD, Dingledine RJ. Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet. Ann Neurol. 2006 Aug;60(2):223-35.19.         Yang X, Cheng B. Neuroprotective and anti-inflammatory activities of ketogenic diet on MPTP-induced neurotoxicity. J Mol Neurosci. 2010 Oct;42(2):145-53.20.         Krikorian R, Shidler MD, Dangelo K, Couch SC, Benoit SC, Clegg DJ. Dietary ketosis enhances memory in mild cognitive impairment. Neurobiol Aging. 2012

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22.         Maynard SD, Gelblum J. Retrospective cohort study of the efficacy of caprylic triglyceride in patients with mild-to-moderate alzheimer’s disease. Neuropsychiatr Dis Treat. 2013;9:1619-27.23.         Farah BA. Effects of caprylic triglyceride on cognitive performance and cerebral glucose metabolism in mild Alzheimer’s disease: a single-case observation. Front Aging Neurosci. 2014 Jul 16;6:133.24.         Ohnuma T, Toda A, Kimoto A, et al. Benefits of use, and tolerance of, medium-chain triglyceride medical food in the management of Japanese patients with Alzheimer’s disease: a prospective, open-label pilot study. Clin Interv Aging. 2016 Jan 8;11:29-36.

  1. Gandotra S, Kour J, Van der Waag A. Efficacy of Adjunctive Extra Virgin Coconut Oil Use in Moderate to Severe Alzheimer’s Disease. Int J Sch Cog Psychol 2014, 1:2

26.         Kapogiannis D, Mattson MP. Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer’s disease. Lancet Neurol. 2011 Feb;10(2):187-98.

  1. Mattson MP. Challenging oneself intermittently to improve health. Dose Response. 2014 Oct 20;12(4):600-18.

28.         Wahl D, Cogger VC, Solon-Biet SM, Waern RV, Gokarn R, Pulpitel T, Cabo Rd, Mattson MP, Raubenheimer D, Simpson SJ, Le Couteur DG. Nutritional strategies to optimise cognitive function in the aging brain. Ageing Res Rev. 2016 Nov;31:80-92.29.         Witte AV, Fobker M, Gellner R, Knecht S, Flöel A. Caloric restriction improves memory in elderly humans. Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1255-60.30.         Martin CK, Anton SD, Han H, York-Crowe E, Redman LM, Ravussin E, Williamson DA. Examination of cognitive function during six months of calorie restriction: results of a randomized controlled trial. Rejuvenation Res. 2007 Jun;10(2):179-90.31.         Scott TM, Rasmussen HM, Chen O, Johnson EJ. Avocado Consumption Increases Macular Pigment Density in Older Adults: A Randomized, Controlled Trial. Nutrients. 2017 Aug 23;9(9). 32.         Krikorian R, Shidler MD, Nash TA, Kalt W, Vinqvist-Tymchuk MR, Shukitt-Hale B, Joseph JA. Blueberry supplementation improves memory in older adults. J Agric Food Chem. 2010 Apr 14;58(7):3996-4000.

  1. Rita Cardoso B, Apolinário D, da Silva Bandeira V, et al. Effects of Brazil nut consumption on selenium status and cognitive performance in older adults with mild cognitive impairment: a randomized controlled pilot trial.Eur J Nutr. 2016 Feb;55(1):107-16.

34.         Kent K, Charlton K, Roodenrys S, et al. Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia. Eur J Nutr. 2017 Feb;56(1):333-341.

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36.         Krikorian R, Boespflug EL, Fleck DE, Stein AL, Wightman JD, Shidler MD, Sadat-Hossieny S. Concord grape juice supplementation and neurocognitive function in human aging. J Agric Food Chem. 2012 Jun 13;60(23):5736-42.37.         Ide K, Yamada H, Takuma N, Park M, Wakamiya N, Nakase J, Ukawa Y, Sagesaka YM. Green tea consumption affects cognitive dysfunction in the elderly: a pilot study. Nutrients. 2014 Sep 29;6(10):4032-42.38.         Parachikova A, Green KN, Hendrix C, LaFerla FM. Formulation of a medical food cocktail for Alzheimer’s disease: beneficial effects on cognition and neuropathology in a mouse model of the disease. PLoS One. 2010 Nov 17;5(11):e14015. 39.         Chan A, Paskavitz J, Remington R, et al. Efficacy of a vitamin/nutriceutical formulation for early-stage Alzheimer’s disease: a 1 year, open-label pilot study with an 16-month caregiver extension. Am J Alzheimers Dis Other Demen. 2008 Dec-2009 Jan;23(6):571-85. 40.         Remington R, Bechtel C, Larsen D, et al. A Phase II Randomized Clinical Trial of a Nutritional Formulation for Cognition and Mood in Alzheimer’s Disease. J Alzheimers Dis. 2015;45(2):395-405.41.         Remington R, Bechtel C, Larsen D, et al. Maintenance of Cognitive Performance and Mood for Individuals with Alzheimer’s Disease Following Consumption of a Nutraceutical Formulation: A One-Year, Open-Label Study. J Alzheimers Dis. 2016;51(4):991-5. 42.         Zanotta D, Puricelli S, Bonoldi G. Cognitive effects of a dietary supplement made from extract of Bacopa monnieri, astaxanthin, phosphatidylserine, and vitamin E in subjects with mild cognitive impairment: a noncomparative, exploratory clinical study. Neuropsychiatr Dis Treat. 2014 Feb 3;10:225-30.43.         Galasko DR, Peskind E, Clark CM, Quinn JF, Ringman JM, Jicha GA, Cotman C, Cottrell B, Montine TJ, Thomas RG, Aisen P; Alzheimer’s Disease Cooperative Study. Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. Arch Neurol. 2012 Jul;69(7):836-41.44.         Smith AD, Refsum H. Homocysteine, B Vitamins, and Cognitive Impairment. Annu Rev Nutr. 2016 Jul 17;36:211-39.45.         Douaud G, Refsum H, de Jager CA, Jacoby R, Nichols TE, Smith SM, Smith AD. Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9523-8.

  1. de Jager CA, Oulhaj A, Jacoby R, Refsum H, Smith AD. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: A randomized controlled trial. Int J Geriatr Psychiatry. 2012;27(6):592–600.

47.         Cheng D, Kong H, Pang W, Yang H, Lu H, Huang C, Jiang Y. B vitamin supplementation improves cognitive function in the middle aged and elderly with hyperhomocysteinemia. Nutr Neurosci. 2016 Dec;19(10):461-466.48.         Oulhaj A, Jernerén F, Refsum H, Smith AD, de Jager CA. Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment. J Alzheimers Dis. 2016;50(2):547-57.49.         Ma F, Wu T, Zhao J, Han F, Marseglia A, Liu H, Huang G. Effects of 6-Month Folic Acid Supplementation on Cognitive Function and Blood Biomarkers in Mild Cognitive Impairment: A Randomized Controlled Trial in China. J Gerontol A Biol Sci Med Sci. 2016 Oct;71(10):1376-83.50.         Chen H, Liu S, Ji L, Wu T, Ji Y, Zhou Y, Zheng M, Zhang M, Xu W, Huang G. Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial. Mediators Inflamm. 2016;2016:5912146.51.         Werder SF. Cobalamin deficiency, hyperhomocysteinemia, and dementia. Neuropsychiatr Dis Treat. 2010 May 6;6:159-95.52.         Eastley R, Wilcock GK, Bucks RS. Vitamin B12 deficiency in dementia and cognitive impairment: the effects of treatment on neuropsychological function. Int J Geriatr Psychiatry. 2000 Mar;15(3):226-33.53.         Kwok T, Lee J, Lam L, Woo J. Vitamin B(12) supplementation did not improve cognition but reduced delirium in demented patients with vitamin B(12) deficiency. Arch Gerontol Geriatr. 2008 May-Jun;46(3):273-82.54.         van Dyck CH, Lyness JM, Rohrbaugh RM, Siegal AP. Cognitive and psychiatric effects of vitamin B12 replacement in dementia with low serum B12 levels: a nursing home study. Int Psychogeriatr. 2009 Feb;21(1):138-47.55.         Chai GS, Jiang X, Ni ZF, Ma ZW, Xie AJ, Cheng XS, Wang Q, Wang JZ, Liu GP. Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine. J Neurochem. 2013 Feb;124(3):388-96.56.         Sun J, Wen S, Zhou J, Ding S. Association between malnutrition and hyperhomocysteine in Alzheimer’s disease patients and diet intervention of betaine. J Clin Lab Anal. 2016 Nov 7. doi: 10.1002/jcla.22090. [Epub ahead of print]57.         Wu S, Ding Y, Wu F, Li R, Hou J, Mao P. Omega-3 fatty acids intake and risks of dementia and Alzheimer’s disease: a meta-analysis. Neurosci Biobehav Rev. 2015 Jan;48:1-9.58.         Ammann EM, Pottala JV, Robinson JG, Espeland MA, Harris WS. Erythrocyte omega-3 fatty acids are inversely associated with incident dementia: Secondary analyses of longitudinal data from the Women’s Health Initiative Memory Study (WHIMS). Prostaglandins Leukot Essent Fatty Acids. 2017 Jun;121:68-75.59.         Pottala JV, Yaffe K, Robinson JG, Espeland MA, Wallace R, Harris WS. Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study. Neurology. 2014 Feb 4;82(5):435-42.60.         Fraga VG, Carvalho MDG, Caramelli P, de Sousa LP, Gomes KB. Resolution of inflammation, n-3 fatty acid supplementation and Alzheimer disease: A narrative review. J Neuroimmunol. 2017 Sep 15;310:111-119.61.         Freund Levi Y, Vedin I, Cederholm T, Basun H, Faxén Irving G, Eriksdotter M, Hjorth E, Schultzberg M, Vessby B, Wahlund LO, Salem N Jr, Palmblad J. Transfer of omega-3 fatty acids across the blood-brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer’s disease: the OmegAD study. J Intern Med. 2014 Apr;275(4):428-36.62.         Eriksdotter M, Vedin I, Falahati F, Freund-Levi Y, Hjorth E, Faxen-Irving G, Wahlund LO, Schultzberg M, Basun H, Cederholm T, Palmblad J. Plasma Fatty Acid Profiles in Relation to Cognition and Gender in Alzheimer’s Disease Patients During Oral Omega-3 Fatty Acid Supplementation: The OmegAD Study. J Alzheimers Dis. 2015;48(3):805-12.63.         Vedin I, Cederholm T, Freund-Levi Y, Basun H, Garlind A, Irving GF, Eriksdotter-Jönhagen M, Wahlund LO, Dahlman I, Palmblad J. Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study. PLoS One. 2012;7(4):e35425.64.         Nock TG, Chouinard-Watkins R, Plourde M. Carriers of an apolipoprotein E epsilon 4 allele are more vulnerable to a dietary deficiency in omega-3 fatty acids and cognitive decline. Biochim Biophys Acta. 2017 Oct;1862(10 Pt A):1068-1078.65.         Holmquist L, Stuchbury G, Berbaum K, Muscat S, Young S, Hager K, Engel J, Münch G. Lipoic acid as a novel treatment for Alzheimer’s disease and related dementias. Pharmacol Ther. 2007 Jan;113(1):154-64.

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67.         Shinto L, Quinn J, Montine T, et al. A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer’s disease. J Alzheimers Dis. 2014;38(1):111 20.68.         Pepeu G, Pepeu IM, Amaducci L. A review of phosphatidylserine pharmacological and clinical effects. Is phosphatidylserine a drug for the ageing brain?Pharmacol Res. 1996 Feb;33(2):73-80.69.         Richter Y, Herzog Y, Lifshitz Y, Hayun R, Zchut S. The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study. Clin Interv Aging. 2013;8:557-63.70.         Richter Y, Herzog Y, Cohen T, Steinhart Y. The effect of phosphatidylserine-containing omega-3 fatty acids on memory abilities in subjects with subjective memory complaints: a pilot study. Clin Interv Aging. 2010 Nov 2;5:313-6.71.         Moré MI, Freitas U, Rutenberg D. Positive effects of soy lecithin-derived phosphatidylserine plus phosphatidic acid on memory, cognition, daily functioning, and mood in elderly patients with Alzheimer’s disease and dementia. Adv Ther. 2014 Dec;31(12):1247-672.         Kato-Kataoka A, Sakai M, Ebina R, Nonaka C, Asano T, Miyamori T. Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. J Clin Biochem Nutr. 2010 Nov;47(3):246-5573.         Skvarc DR, Dean OM, Byrne LK, Gray L, Lane S, Lewis M, Fernandes BS, Berk M, Marriott A. The effect of N-acetylcysteine (NAC) on human cognition – A systematic review. Neurosci Biobehav Rev. 2017 Jul;78:44-56.

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  1. DiNicolantonio JJ et al. Targeting aspirin resistance with nutraceuticals: A possible strategy for reducing cardiovascular morbidity and mortality. Open Heart 2017, 4(2).
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Frank M. Faraci. Arteriosclerosis, Thrombosis, and Vascular Biology 2006;26:1931-1933.

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Devries S et al. A deficiency of nutrition education and practice in cardiology. Am J Med 2017, 127: 9.

Maryam Sharifi‐Sanjani, Nicholas M. Oyster, Elisia D. Tichy, Kenneth C. Bedi, Ofer Harel, Kenneth B. Margulies, Foteini Mourkioti. Cardiomyocyte‐Specific Telomere Shortening is a Distinct Signature of Heart Failure in Humans. Journal of the American Heart Association, September 2017 DOI: 10.1161/JAHA.116.005086.

FRONTIERS: Simon Mills
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Paul Gellert, Petra von Berenberg, Monika Oedekoven, Maria Klemt, Christine Zwillich, Stefan Hörter, Adelheid Kuhlmey, Dagmar Dräger. Centenarians Differ in Their Comorbidity Trends During The 6 Years Before Death Compared to Individuals Who Died in Their 80s or 90s. The Journals of Gerontology: Series A, 2017; DOI: 10.1093/gerona/glx136.

Ashley A. Ross, Andrew C. Doxey, Josh D. Neufeld. The Skin Microbiome of Cohabiting Couples. mSystems, July 2017 DOI: 10.1128/mSystems.00043-17 .

Claire T. McEvoy, Heidi Guyer, Kenneth M. Langa, Kristine Yaffe. Neuroprotective Diets Are Associated with Better Cognitive Function: The Health and Retirement Study. Journal of the American Geriatrics Society, 2017; DOI: 10.1111/jgs.14922.

Eric L. Garland, Anne K. Baker, Paula Larsen, Michael R. Riquino, Sarah E. Priddy, Elizabeth Thomas, Adam W. Hanley, Patricia Galbraith, Nathan Wanner, Yoshio Nakamura. Randomized Controlled Trial of Brief Mindfulness Training and Hypnotic Suggestion for Acute Pain Relief in the Hospital Setting. Journal of General Internal Medicine, 2017; DOI: 10.1007/s11606-017-4116-9.

Ather Ali, Theresa R Weiss, Douglas McKee, Alisa Scherban, Sumiya Khan, Maxine R Fields, Damian Apollo, Wajahat Z Mehal. Efficacy of individualised diets in patients with irritable bowel syndrome: a randomised controlled trial. BMJ Open Gastroenterology, 2017; 4 (1): e000164 DOI: 10.1136/bmjgast-2017-000164

Ling Wu, Paul Velander, Dongmin Liu, Bin Xu. Olive component oleuropein promotes β-cell insulin secretion and protects β-cells from amylin amyloid induced cytotoxicity. Biochemistry, 2017; DOI: 10.1021/acs.biochem.7b00199.

M F Hjorth, H M Roager, T M Larsen, S K Poulsen, T R Licht, M I Bahl, Y Zohar, A Astrup.

Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention. International Journal of Obesity, 2017; DOI: 10.1038/ijo.2017.220.


In Focus - Lyme Disease 2017

[1] Sapi E, Kaur N, Anyanwu S, Luecke DF, Datar A, Patel S, Rossi M, Stricker RB (2011) Evaluation of in-vitro antibiotic susceptibility of different morphological forms of Borrelia burgdorferi.  Infect Drug Resist 4:97-113



[1] Kenedy MR, Lenhart TR, Akins DR (2012) The role of Borrelia burgdorferi Outer Surface Proteins.  FEMS Immunol Med Microbiol 66:1-19



[1] Zhang J-R, Norris SJ (1998) Kinetics and in vivo induction of genetic variation of vlsE in Borrelia burgdorferi.  Infection and Immunity 66:3689-3697



[1] Embers ME, Ramamoorthy R, Philipp MT (2004) Survival strategies of Borrelia burgdorferi, the etiologic agent of Lyme disease.  Microbes and Infection 6:312-318



[1] Kuehn BM (2013) CDC estimates 300000 US cases of Lyme disease annually.  JAMA 310: 1110



[1] Lindgren E, Jaenson T and World Health Organization (2006) Lyme borreliosis in Europe: influences and climate change, epidemiology, ecology and adaptation measures. World Health Organization Regional Office for Europe



[1] Van den Wijngaard CC, Hofhuls A, Simoes M, Rood E, van Pelt W, Zeller H, Van Bortel W (2017) Surveillance perspective on Lyme borreliosis across the European Union and European Economic Area.  Euro Surveill 22 pii=30569



[1] Dubrey SW, Bhatia A, Woodham S, Rakowicz W (2013) Lyme disease in the United Kingdom.  Postgrad Med J 90:33-42



[1] Semenza JC, Menne B (2009) Climate change and infectious diseases in Europe. Lancet 9:365-375.



[1]Semenza JC, Menne B (2009) Climate change and infectious diseases in Europe. Lancet 9:365-375.



[1] Shaw SE, Day MJ, Birtles RJ, Breitschwerdt EB (2001) Tick-borne infectious diseases of dogs.  Trends in parasitology 17:74-80



[1] Harvey WT, Salvato P (2003) ‘Lyme disease’: ancient engine of an unrecognized borreliosis pandemic?  Medical Hypotheses 60:742-759



[1] Munro H, Mavin S, Duffy K, Evans R, Jarvis LM (2015) Seroprevalence of lyme borreliosis in Scottish blood donors.  Transfusion Medicine 25:284-286



[1] Zambrano MC, Beklemisheva AA, Bryksin AV, Newman SA, Cabello FC (2004) Borrelia burgdorferi binds to, invades and colonizes Native Type I Collagen Lattices.  Infection and Immunity 72:3138-3146



[1] Muller KE (2012) Damage of collagen and elastin fibres by Borrelia burgdorferi—known and new clinical and histopathological aspects.  The Open Neurology Journal 6(Suppl 1-M11):179-186



[1] Zambrano MC, Beklemisheva AA, Bryksin AV, Newman SA, Cabello FC (2004) Borrelia burgdorferi binds to, invades and colonizes Native Type I Collagen Lattices.  Infection and Immunity 72:3138-3146



[1] Tilly K, Rosa PA, Stewart PE (2008) Biology of infection with Borrelia burgdorferiInfect Dis Clin North Am 22:217-234



[1] Envita medical Centre (2017) Symptoms of Lyme Disease—the Great Imitator. Available at:  [Accessed 6th September 2017][1] Ingram C (2015) Lyme Disease Mimics a Vast Number of Other Diseases.   Available at:   [Accessed 7th September 2017][1] Gülçin I, Oktay M, Kireçci E, Küfrevioğlu I (2003) Screening of antioxidant and antimicrobial activities of anise (Pimpinella anisum L.) seed extracts.  Food Chemistry 83:371-382



[1] Francis G, Karem Z, Makkar HP, Becker K (2002) The biological action of saponins in animal systems: a review.  Br J Nutr 88:587-605.



[1] Kim B-Y, Cui Z-G, Lee S-R, Kim S-J, Kang H-K, Lee Y-K, Park D-B (2009) Effects of Asparagus officinalis extracts on cell toxicity and ethanol metabolism.  Journal of Food Science 74:H204-208



[1] Arthur S (2007) The effectiveness of Samento, Cumanda, Burbur and Dr Lee Cowden’s Protocol in the treatment of chronic Lyme disease.  Townsend Letter for Doctors and Patients 285:101



[1] Tan KH, Seers CA, Dashper SG, Mitchell HL, Pyke JS, Meuric V, Slakeski N, Cheal SM, Chambers JL, McConville MJ, Reynolds EC (2014) Porphyromonas gingivalis and Treponema denticola exhibit metabolic symbioses. PLoS Pathog 10(3): e1003955



[1] Brambilla E, Gagetti MG, Ionescu A, Campus G, Lingstrom P (2014) An in vitro and in vivo comparison of the effect of Stevia rebaudiana extracts on different caries-related variables: a randomized controlled trial pilot study.  Caries Res 48:19-23



[1] Theophilus PAS, Victoria MJ, Socarras KM, Filush KR, Gupta K, Luecke DF, Sapi E (2015) Effectiveness of Stevia rebaudiana whole leaf extract against the various morphological forms of Borrelia burgdorferi in vitroEuropean Journal of Microbiology and Immunology 5:268-280.



[1] Dryden M, Gaff H, McCombs G, Medlock J, Pietzsch M (2015) The dangers of tick-borne diseases: considerations for dental professionals. DH & T October:26-29



[1] Drenckhahn A, Spors B,Knierim E (2016) Acute isolated partial oculomotor nerve palsy due to Lyme neuroborreliosis in a 5 year old girl.  European Journal of Paediatric Neurology 20:977-979



[1] Lesser RL (1995) Ocular manifestations of Lyme disease.  The American Journal of Medicine 98(4): Supplement 1:60S-62S



[1] Guliani BP, Kuman S, Chawla N, Mehta A (2017) Neuroretinitis as presenting and the only presentation of Lyme disease: Diagnosis and management.  Indian Journal of Ophthalmology 65(3) 250-25



[1] Guliani BP, Kuman S, Chawla N, Mehta A (2017) Neuroretinitis as presenting and the only presentation of Lyme disease: Diagnosis and management.  Indian Journal of Ophthalmology 65(3) 250-252



[1] Klig JE (2008) Ophthalmologic Complications of Systemic Disease.  Emerg Med Clin N. Am 26:217-231Klig



[1] Steere AC, Duray PH, Kauffmann JH, Wormser GP (1985) Unilateral Blindness Caused by Infection with the Lyme Disease Spirochete, Borrelia burgdorferiAnnals of Internal Medicine 103(3): 382-384



[1] World Health Organization (2017) Trachoma.  Available at:    [Accessed 6th September 2017][1] Envita Medical Centre (2017)  Bartonella, a chronic Lyme disease coinfection, is more causing chronic fatigue problems.   Available at:  [Accessed 6th September 2017][1] Klig JE (2008) Ophthalmologic Complications of Systemic Disease.  Emerg Med Clin N. Am 26:217-231



[1] Klig JE (2008) Ophthalmologic Complications of Systemic Disease.  Emerg Med Clin N. Am 26:217-231



[1] Denniston AK, Keane PA (2015) Letter: Paravascular Pathways in the Eye: Is there an ‘Ocular Glymphatic System’?   Invest Ophthalmol Vis Sci 56:3955-3956




Lyme Disease and linked conditions:


  1. Luger SW (1990) Lyme disease transmitted by a biting fly. New England Journal of Medicine 322 (24):1752.
  2. Stricker RB, Middelveen MJ (2015) Sexual transmission of Lyme disease: challenging the tickborne disease paradigm. Expert review of anti-infective therapy 13 (11):1303-1306.
  3. Klempner MS, Schmid CH, Hu L, Steere AC, Johnson G, McCloud B, Noring R, Weinstein A (2001) Intralaboratory reliability of serologic and urine testing for Lyme disease. American Journal of Medicine 110 (3):217-219.
  4. Ghoneum M, Abedi S (2004) Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran). Journal of Pharmacy and Pharmacology 56 (12):1581-1588.
  5. Perez-Martinez A, Valentin J, Fernandez L, Hernandez-Jimenez E, Lopez-Collazo E, Zerbes P, Schworer E, Nunez F, Martin IG, Sallis H, Diaz MA, Handgretinger R, Pfeiffer MM (2015) Arabinoxylan rice bran (MGN-3/Biobran) enhances natural killer cell-mediated cytotoxicity against neuroblastoma in vitro and in vivo. Cytotherapy 17 (5):601-612.
September 2017


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Andrew Kingston, Pia Wohland, Raphael Wittenberg, Louise Robinson, Carol Brayne, Fiona E Matthews, Carol Jagger, E Green, L Gao, R Barnes, A Arthur, C Baldwin, L E Barnes, C Brayne, A Comas-Herrera, T Dening, G Forster, S Harrison, P G Ince, C Jagger, F E Matthews, I G McKeith, B Parry, J Pickett, L Robinson, B C M Stephan, S Wharton, R Wittenberg, B Woods, R Weller. Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS). The Lancet, 2017; DOI: 10.1016/S0140-6736(17)31575-1.  

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Robert Sonowal, Alyson Swimm, Anusmita Sahoo, Liping Luo, Yohei Matsunaga, Ziqi Wu, Jui A. Bhingarde, Elizabeth A. Ejzak, Ayush Ranawade, Hiroshi Qadota, Domonica N. Powell, Christopher T. Capaldo, Jonathan M. Flacker, Rhienallt M. Jones, Guy M. Benian, and Daniel Kalman. Indoles from commensal bacteria extend healthspan. PNAS, August 21, 2017 DOI: 10.1073/pnas.1706464114

Olga Theou, Joanna M. Blodgett, Judith Godin, Kenneth Rockwood. Association between sedentary time and mortality across levels of frailty. Canadian Medical Association Journal, 2017; 189 (33): E1056 DOI: 10.1503/cmaj.161034.

Austin T. Mudd, Kirsten Berding, Mei Wang, Sharon M. Donovan, Ryan N. Dilger. Serum cortisol mediates the relationship between fecal Ruminococcus and brain N-acetylaspartate in the young pig. Gut Microbes, 2017; 1 DOI: 10.1080/19490976.2017.1353849

 Pinaki Panigrahi, Sailajanandan Parida, Nimai C. Nanda, Radhanath Satpathy, Lingaraj Pradhan, Dinesh S. Chandel, Lorena Baccaglini, Arjit Mohapatra, Subhranshu S. Mohapatra, Pravas R. Misra, Rama Chaudhry, Hegang H. Chen, Judith A. Johnson, J. Glenn Morris, Nigel Paneth, Ira H. Gewolb. A randomized synbiotic trial to prevent sepsis among infants in rural India. Nature, 2017; DOI: 10.1038/nature23480

 Claire E Berryman, Jennifer A Fleming, Penny M Kris-Etherton. Inclusion of Almonds in a Cholesterol-Lowering Diet Improves Plasma HDL Subspecies and Cholesterol Efflux to Serum in Normal-Weight Individuals with Elevated LDL Cholesterol. The Journal of Nutrition, 2017; 147 (8): 1517 DOI: 10.3945/jn.116.245126






In Focus - Gut Health



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Liu C, Dunkin D, Lai J, Song Y, Ceballos C, Benkov K, Li XM. Anti-inflammatory Effects of Gaderma lucidum Triterpenoid in Human Crohn’s Disease Associated with Downregulation of NF

Signaling. Inflamm Bowel Dis. 2015 Aug;21(8):1918-25. doi: 10.1097/MIB.0000000000000439.

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Takenaka MC, Robson S, Quintana FJ. Regulation of the T Cell Response by CD39. Trends Imunol. 2016 May 25. pii: S1471-4906(16)30031-X. doi: 10.1016/ [Epub ahead of print

The impact of antibiotics

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August 2017


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Frontiers in Aging Neuroscience 2017; 9 : 168. Neuroprotective and Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants. Muhammad Ayaz, Abdul Sadiq, Muhammad Junaid, Farhat Ullah, Fazal Subhan, Jawad Ahmed. PMID: 28611658.

Osada H, Okamoto T, Kawashima H, Toda, E, Miyake S, Nagai N, et al. (2017) Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina. PLoS ONE 12(6): e0178627.

Kirsten E. Bell, Tim Snijders, Michael Zulyniak, Dinesh Kumbhare, Gianni Parise, Adrian Chabowski, Stuart M. Phillips. A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial. PLOSONE, 2017; 12 (7): e0181387 DOI: 10.1371/journal.pone.0181387.

Timothy J. Wilt, Karen M. Jones, Michael J. Barry, Gerald L. Andriole, Daniel Culkin, Thomas Wheeler, William J. Aronson, Michael K. Brawer. Follow-up of Prostatectomy versus Observation for Early Prostate Cancer. New England Journal of Medicine, 2017; 377 (2): 132 DOI: 10.1056/NEJMoa1615869.

Meghan B. Azad, Ahmed M. Abou-Setta, Bhupendrasinh F. Chauhan, Rasheda Rabbani, Justin Lys, Leslie Copstein, Amrinder Mann, Maya M. Jeyaraman, Ashleigh E. Reid, Michelle Fiander, Dylan S. MacKay, Jon McGavock, Brandy Wicklow, Ryan Zarychanski. Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. Canadian Medical Association Journal, 2017; 189 (28): E929 DOI: 10.1503/cmaj.161390

Rebecca Spain, Katherine Powers, Charles Murchison, Elizabeth Heriza, Kimberly Winges, Vijayshree Yadav, Michelle Cameron, Ed Kim, Fay Horak, Jack Simon, Dennis Bourdette. Lipoic acid in secondary progressive MS. Neurology – Neuroimmunology Neuroinflammation, 2017; 4 (5): e374 DOI: 10.1212/NXI.0000000000000374

BEN BROWN endotoxin

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  8. Erridge C. Stimulants of Toll-like receptor (TLR)-2 and TLR-4 are abundant in certain minimally-processed vegetables. Food Chem Toxicol. 2011 Jun;49(6):1464-7.
  9. Erridge C. Diet, commensals and the intestine as sources of pathogen-associated molecular patterns in atherosclerosis, type 2 diabetes and non-alcoholic fatty liver disease. Atherosclerosis. 2011 May;216(1):1-6.
  10. Herieka M, Faraj TA, Erridge C. Reduced dietary intake of pro-inflammatory Toll-like receptor stimulants favourably modifies markers of cardiometabolic risk in healthy men. Nutr Metab Cardiovasc Dis. 2016 Mar;26(3):194-200.

Endotoxin and atherosclerosis (Simon Martin)

  1. Clett Erridge, Teresa Attina, Corinne M Spickett and David J Webb. A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation. Am J Clin Nutr 2007, 86 (5):1286-92. Online at
    2. Swaroop Pendyala, Jeanne M. Walker, and Peter R. Holt

A High-Fat Diet Is Associated With Endotoxemia That Originates From the Gut.

Gastroenterology. 2012 May; 142(5): 1100–1101.e2.

Published online 2012 Feb 8. doi:  10.1053/j.gastro.2012.01.034

Ice Man
M. Kox, L. T. van Eijk, J. Zwaag, J. van den Wildenberg, F. C. G. J. Sweep, J. G. van der Hoeven, P. Pickkers. Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans. Proceedings of the National Academy of Sciences, 2014; DOI: 10.1073/pnas.1322174111

SIMON MILLS – Cinnamon

  1. Dalby, A (2000). Dangerous Tastes: The Story of Spices.  British Library, London.
  2. Vincent, W (1800) The Periplus of the Erythrean Sea: Part the First. London
  3. He ZD, Qiao CF Han QB et al (2005). Authentication and quantitative analysis on the chemical profile of cassia bark (cortex cinnamomi) by high-pressure liquid chromatography. J Agric Food Chem vol 53, no 7, pp 2424-8
  4. EFSA (European Food Safety Authority) (2008) Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC): Question No EFSA-Q-2008-677. “Coumarin in flavourings and other food ingredients with flavouring properties”. The EFSA Journal, vol 793, pp 1-15
  5. Crawford P, Thai C, Obholz J, et al (2016) Assessment of the effect of lIfestyle intervention plus water-soluble cinnamon extract on lowering blood glucose in pre-diabetics, a randomized, double-blind, multicenter, placebo controlled trial: study protocol for a randomized controlled trial. vol 5, no 17,p 9
  6. Zhang Z, Ye F, Wiseman N, and Mitchell, C (1999). Shang Han Lun: On Cold Damage, Translation and Commentaries. Paradigm Publications
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  8. Perry LM (1980) Medicinal plants of East and Southeast Asia: attributed properties and uses. MIT Press

EFA research

Aram Asatryan, Nicolas G. Bazan. Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection. Journal of Biological Chemistry, 2017; jbc.R117.783076 DOI: 10.1074/jbc.R117.783076

Daniel R. McDougle, Josephine E. Watson, Amr A. Abdeen, Reheman Adili, Megan P. Caputo, John E. Krapf, Rodney W. Johnson, Kristopher A. Kilian, Michael Holinstat, Aditi Das. Anti-inflammatory ω-3 endocannabinoid epoxides. Proceedings of the National Academy of Sciences, 2017; 201610325 DOI: 10.1073/pnas.1610325114

Abdo Alnabulsi et al. The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance, British Journal of Cancer (2017). DOI: 10.1038/bjc.2017.135

Jana Trebatická, et al. Emulsified omega-3 fatty-acids modulate the symptoms of depressive disorder in children and adolescents: a pilot study. Child and Adolescent Psychiatry and Mental Health201711:30. DOI: 10.1186/s13034-017-0167-2. Online at

Benjamin J. Andreone, Brian Wai Chow, Aleksandra Tata, Baptiste Lacoste, Ayal Ben-Zvi, Kevin Bullock, Amy A. Deik, David D. Ginty, Clary B. Clish, Chenghua Gu. Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. Neuron, 2017; 94 (3): 581 DOI: 10.1016/j.neuron.2017.03.043


Victoria A. Acosta-Rodríguez, Marleen H.M. de Groot, Filipa Rijo-Ferreira, Carla B. Green, Joseph S. Takahashi. Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System. Cell Metabolism, 2017; 26 (1): 267 DOI: 10.1016/j.cmet.2017.06.007

Chen-Song Zhang, Simon A. Hawley, Yue Zong, Mengqi Li, Zhichao Wang, Alexander Gray, Teng Ma, Jiwen Cui, Jin-Wei Feng, Mingjiang Zhu, Yu-Qing Wu, Terytty Yang Li, Zhiyun Ye, Shu-Yong Lin, Huiyong Yin, Hai-Long Piao, D. Grahame Hardie, Sheng-Cai Lin. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature, 2017; DOI: 10.1038/nature23275.


Jeffrey Lienert, Christopher Steven Marcum, John Finney, Felix Reed-Tsochas, Laura Koehly. Social influence on 5-year survival in a longitudinal chemotherapy ward co-presence network. Network Science, 2017; 1 DOI: 10.1017/nws.2017.16

Colter Mitchell, Sara McLanahan, Lisa Schneper, Irv Garfinkel, Jeanne Brooks-Gunn, Daniel Notterman. Father Loss and Child Telomere Length. Pediatrics, 2017; e20163245 DOI: 10.1542/peds.2016-3245.

Alexander L. Carlson, Kai Xia, M. Andrea Azcarate-Peril, Barbara D. Goldman, Mihye Ahn, Martin A. Styner, Amanda L. Thompson, Xiujuan Geng, John H. Gilmore, Rebecca C. Knickmeyer. Infant Gut Microbiome Associated with Cognitive Development. Biological Psychiatry, 2017; DOI: 10.1016/j.biopsych.2017.06.021.

David C. Emery, Deborah K. Shoemark, Tom E. Batstone, Christy M. Waterfall, Jane A. Coghill, Tanya L. Cerajewska, Maria Davies, Nicola X. West, Shelley J. Allen. 16S rRNA Next Generation Sequencing Analysis Shows Bacteria in Alzheimer’s Post-Mortem Brain. Frontiers in Aging Neuroscience, 2017; 9 DOI: 10.3389/fnagi.2017.00195

July 2017


Marc M Cohen, De Villiers Smit, Nick Andrianopoulos, Michael Ben-Meir, David McD Taylor, Shefton J Parker, Chalie C Xue, Peter A Cameron. Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non-inferiority trial. The Medical Journal of Australia, 2017; 206 (11): 494 DOI: 10.5694/mja16.00771

Annika S. Axelsson et al. Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes. Science Translational Medicine, 2017 DOI: 10.1126/scitranslmed.aah4477

Daniel G. Amen, William S. Harris, Parris M. Kidd, Somayeh Meysami, and Cyrus A. Raji. Quantitative Erythrocyte Omega-3 EPA Plus DHA Levels Are Related to Higher Regional Cerebral Blood Flow on Brain SPECT. Journal of Alzheimer’s Disease, May 2017 DOI: 10.3233/JAD-17028

Higher Antioxidant Activity, Total Flavonols, and Specific Quercetin Glucosides in Two Different Onion (Allium cepa L.) Varieties Grown under Organic Production: Results from a 6-Year Field Study. Feiyue Ren Kim Reilly, Joseph P. Kerry, Michael Gaffney, Mohammad Hossain, and Dilip K. Rai

  1. Agric. Food Chem., DOI: 10.1021/acs.jafc.7b01352.

Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association. Frank M. Sacks, Alice H. Lichtenstein, Jason H.Y. Wu, Lawrence J. Appel, Mark A. Creager, Penny M. Kris-Etherton, Michael Miller, Eric B. Rimm, Lawrence L. Rudel, Jennifer G. Robinson, Neil J. Stone, Linda V. Van Horn, On behalf of the American Heart Association.

Circulation. 2017; originally published June 15, 2017.

“Study Confirms: Trans Fats Policy Killed Millions”:


1.Ruemmele FM. Role of Diet in Inflammatory Bowel Disease. Ann Nutr Metab. 2016;68 Suppl 1:33-41.

2.Vindigni SM, Zisman TL, Suskind DL, Damman CJ. The intestinal microbiome,  barrier function, and immune system in inflammatory bowel disease: a tripartite pathophysiological circuit with implications for new therapeutic directions. Therap Adv Gastroenterol. 2016 Jul;9(4):606-25

  1. Lee D, Albenberg L, Compher C, Baldassano R, Piccoli D, Lewis JD, Wu GD. Diet in the pathogenesis and treatment of inflammatory bowel diseases. Gastroenterology. 2015 May;148(6):1087-106.
  2. Monteiro CA, Moubarac JC, Cannon G, Ng SW, Popkin B. Ultra-processed products are becoming dominant in the global food system. Obes Rev. 2013 Nov;14 Suppl 2:21-8.
  3. Lerner A, Matthias T. Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease. Autoimmun Rev. 2015 Jun;14(6):479-89.
  4. Roberts CL, Rushworth SL, Richman E, Rhodes JM. Hypothesis: Increased consumption of emulsifiers as an explanation for the rising incidence of Crohn’s disease. J Crohns Colitis. 2013 May;7(4):338-41.
  5. Chassaing B, et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 2015 Mar 5;519(7541):92-6
  6. Martino JV, Van Limbergen J, Cahill LE. The Role of Carrageenan and Carboxymethylcellulose in the Development of Intestinal Inflammation. Front Pediatr. 2017 May 1;5:96.
  7. Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, Maza O, Israeli D, Zmora N, Gilad S, Weinberger A, Kuperman Y, Harmelin A, Kolodkin-Gal I, Shapiro H, Halpern Z, Segal E, Elinav E. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014 Oct 9;514(7521):181-6.
  8. Bian X, Chi L, Gao B, Tu P, Ru H, Lu K. The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in CD-1 mice. PLoS One. 2017 Jun 8;12(6):e0178426.
  9. Bian X, Tu P, Chi L, Gao B, Ru H, Lu K. Saccharin induced liver inflammation in mice by altering the gut microbiota and its metabolic functions. Food Chem Toxicol. 2017 May 1. pii: S0278-6915(17)30223-5.
  10. Nickerson KP, et al. Deregulation of intestinal anti-microbial defense by the dietary additive, maltodextrin. Gut Microbes. 2015;6(1):78-8
  11. Lerner A, Aminov R, Matthias T. Transglutaminases in Dysbiosis As Potential Environmental Drivers of Autoimmunity. Front Microbiol. 2017 Jan 24;8:66.
  12. Tobacman JK. Review of harmful gastrointestinal effects of carrageenan in animal experiments. Environ Health Perspect. 2001 Oct;109(10):983-94.
  13. Bhattacharyya S, Shumard T, Xie H, Dodda A, Varady KA, Feferman L, Halline AG, Goldstein JL, Hanauer SB, Tobacman JK. A randomized trial of the effects of the no-carrageenan diet on ulcerative colitis disease activity. Nutr Healthy Aging. 2017 Mar 31;4(2):181-192.


Garner Thomson

Kelley JM et al. The Influence of the Patient-Clinician Relationship on Healthcare Outcomes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. PLOS ONE 2014, 9(6): e101191.

Pennebaker, James W (2013) The Secret Life of Pronouns: What Your Words Say About You. New York: Bloomsbury Publishing.


Eur J Appl Physiol. 2017 Feb;117(2):247-254. doi: 10.1007/s00421-016-3512-x. Epub 2016 Dec 24. Cardiovascular function during supine rest in endurance-trained males with New Zealand blackcurrant: a dose-response study.

Cook MD, Myers SD, Gault ML, Edwards VC, Willems ME.

Nutrients. 2017 May 29;9(6). pii: E556. doi: 10.3390/nu9060556.

Blackcurrant Alters Physiological Responses and Femoral Artery Diameter during Sustained Isometric Contraction. Cook MD, Myers SD, Gault ML, Willems MET.

Br J Nutr. 2015 Jun 14;113(11):1697-703. doi: 10.1017/S0007114515001105. Epub 2015 Apr 22. Polyphenol-rich blackcurrant extract exerts hypocholesterolaemic and hypoglycaemic effects in mice fed a diet containing high fat and cholesterol.

Benn T, Kim B, Park YK, Yang Y, Pham TX, Ku CS, Farruggia C, Harness E, Smyth JA, Lee JY.

Ranjit Kumar, Nengjun Yi, Degui Zhi, Peter Eipers, Kelly T. Goldsmith, Paula Dixon, David K. Crossman, Michael R. Crowley, Elliot J. Lefkowitz, J. Martin Rodriguez, Casey D. Morrow. Identification of donor microbe species that colonize and persist long term in the recipient after faecal transplant for recurrent Clostridium difficile. npj Biofilms and Microbiomes, 2017; 3 (1) DOI: 10.1038/s41522-017-0020-7

Alissa C. Nicolucci, Megan P. Hume, Inés Martínez, Shyamchand Mayengbam, Jens Walter, Raylene A. Reimer. Prebiotic Reduces Body Fat and Alters Intestinal Microbiota in Children With Overweight or Obesity. Gastroenterology, 2017; DOI: 10.1053/j.gastro.2017.05.055.

Becattini et al. Commensal microbes provide first line defense against Listeria monocytogenes infection. J. Exp. Med, 2017 DOI: 10.1084/jem.20170495

Hao Wu, Eduardo Esteve, Valentina Tremaroli, Muhammad Tanweer Khan, Robert Caesar, Louise Mannerås-Holm, Marcus Ståhlman, Lisa M Olsson, Matteo Serino, Mercè Planas-Fèlix, Gemma Xifra, Josep M Mercader, David Torrents, Rémy Burcelin, Wifredo Ricart, Rosie Perkins, José Manuel Fernàndez-Real, Fredrik Bäckhed. Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug. Nature Medicine, 2017; DOI: 10.1038/nm.4345

Zehra Esra Ilhan, John K DiBaise, Nancy G Isern, David W Hoyt, Andrew K Marcus, Dae-Wook Kang, Michael D Crowell, Bruce E Rittmann, Rosa Krajmalnik-Brown. Distinctive microbiomes and metabolites linked with weight loss after gastric bypass, but not gastric banding. The ISME Journal, 2017; DOI: 10.1038/ismej.2017.71

The Gut Microbiota and Autism Spectrum Disorders. Front Cell Neurosci. 2017; 11: 120. Published online 2017 Apr 28. doi:  10.3389/fncel.2017.00120

PMCID: PMC5408485. Qinrui Li,1 Ying Han,1,* Angel Belle C. Dy,2 and Randi J. Hagerman.

Free online at:

Dr David Perlmutter comments from: Autism and Gut Bacteria – Hope Moving Forward at

Buffington et al. Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring. Cell, 2016 DOI: 10.1016/j.cell.2016.06.001


German New Medicine:

Dr Gilbert Renaud:

Dr Bruce Lipton:


Irene Roncero-Ramos, Mónica Mendiola-Lanao, Margarita Pérez-Clavijo, Cristina Delgado-Andrade. Effect of different cooking methods on nutritional value and antioxidant activity of cultivated mushrooms. International Journal of Food Sciences and Nutrition, 2016; 68 (3): 287 DOI: 10.1080/09637486.2016.1244662

Microglia-dependent synapse loss in type I interferon-mediated lupus. Allison R. Bialas et al. Nature 2017, doi:10.1038/nature22821.

Stefan Amisten, Israa Mohammad Al-Amily, Arvind Soni, Ross Hawkes, Patricio Atanes, Shanta Jean Persaud, Patrik Rorsman, Albert Salehi. Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells. Endocrine Journal, 2017; 64 (3): 325 DOI: 10.1507/endocrj.EJ16-0338

Omowunmi Aibana, Molly F. Franke, Chuan-Chin Huang, Jerome T. Galea, Roger Calderon, Zibiao Zhang, Mercedes C. Becerra, Emily R. Smith, Alayne G. Ronnenberg, Carmen Contreras, Rosa Yataco, Leonid Lecca, Megan B. Murray. Impact of Vitamin A and Carotenoids on the Risk of Tuberculosis Progression. Clinical Infectious Diseases, 2017; DOI: 10.1093/cid/cix476

Kaixiong Ye, Feng Gao, David Wang, Ofer Bar-Yosef, Alon Keinan. Dietary adaptation of FADS genes in Europe varied across time and geography. Nature Ecology & Evolution, 2017; 1: 0167 DOI: 10.1038/s41559-017-0167

Santosh Kumar, Angela Downie Ruiz Velasco, Gracjan Michlewski. Oleic Acid Induces MiR-7 Processing through Remodeling of Pri-MiR-7/Protein Complex. Journal of Molecular Biology, 2017; 429 (11): 1638 DOI: 10.1016/j.jmb.2017.05.001

Weronica E. Ek, Elmar W. Tobi, Muhammad Ahsan, Erik Lampa, Erica Ponzi, Soterios A. Kyrtopoulos, Panagiotis Georgiadis, L.H Lumey, Bastiaan T. Heijmans, Maria Botsivali, Ingvar A. Bergdahl, Torgny Karlsson, Mathias Rask-Andersen, Domenico Palli, Erik Ingelsson, Åsa K. Hedman, Lena M. Nilsson, Paolo Vineis, Lars Lind, James M. Flanagan, Åsa Johansson. Tea and coffee consumption in relation to DNA methylation in four European cohorts. Human Molecular Genetics, 2017; DOI: 10.1093/hmg/ddx194

L Pizzuti et al. GLUT 1 receptor expression and circulating levels of fasting glucose in high grade serous ovarian cancer. Journal of Cell Physiology, May 2017 DOI: 10.1002/jcp.26023

Marta K. Zamroziewicz, Erick J. Paul, Chris E. Zwilling, Aron K. Barbey. Determinants of fluid intelligence in healthy aging: Omega-3 polyunsaturated fatty acid status and frontoparietal cortex structure. Nutritional Neuroscience, 2017; 1 DOI: 10.1080/1028415X.2017.1324357



June 2017

IHCAN June references


  1. Aggarwal, T. Fojo, C. Chamberlain, C. Davis, R. Sullivan. Do patient access schemes for high-cost cancer drugs deliver value to society?—lessons from the NHS Cancer Drugs Fund. Annals of Oncology, 2017; DOI: 10.1093/annonc/mdx110.Flory T. Muanda, Odile Sheehy, Anick Bérard. Use of antibiotics during pregnancy and risk of spontaneous abortion. Canadian Medical Association Journal, 2017; 189 (17): E625 DOI: 10.1503/cmaj.161020

Nicholas S. Downing, Nilay D. Shah, Jenerius A. Aminawung et al. Postmarket Safety Events Among Novel Therapeutics Approved by the US Food and Drug Administration Between 2001 and 2010. JAMA, 2017 DOI: 10.1001/jama.2017.5150.

Lucas Morin, Davide L. Vetrano, Debora Rizzuto, Amaia Calderón-Larrañaga, Johan Fastbom, Kristina Johnell. Choosing Wisely? Measuring the Burden of Medications in Older Adults near the End of Life: Nationwide, Longitudinal Cohort Study. The American Journal of Medicine, 2017; DOI: 10.1016/j.amjmed.2017.02.028.

Silverman M, Povitz M, Sontrop JM, Li L, Richard L, Cejic S, Shariff SZ. Antibiotic prescribing for acute non-bacterial upper-respiratory infections in the elderly. Annals of Internal Medicine, 2017 DOI: 10.7326/M16-1131.

Rohit Loomba, Victor Seguritan, Weizhong Li, Tao Long, Niels Klitgord, Archana Bhatt, Parambir Singh Dulai, Cyrielle Caussy, Richele Bettencourt, Sarah K. Highlander, Marcus B. Jones, Claude B. Sirlin, Bernd Schnabl, Lauren Brinkac, Nicholas Schork, Chi-Hua Chen, David A. Brenner, William Biggs, Shibu Yooseph, J. Craig Venter, Karen E. Nelson. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Cell Metabolism, 2017; 25 (5): 1054 DOI: 10.1016/j.cmet.2017.04.001.

Daniela Barone, Letizia Cito, Giuseppina Tommonaro, Agnese Anna Abate, Danila Penon, Rocco De Prisco, Antonella Penon, Iris Maria Forte, Elisabetta Benedetti, Annamaria Cimini, Paola Indovina, Barbara Nicolaus, Francesca Pentimalli, Antonio Giordano. Antitumoral Potential, Antioxidant Activity and Carotenoid Content of Two Southern Italy Tomato Cultivars Extracts: San Marzano and Corbarino. Journal of Cellular Physiology, 2017; DOI: 10.1002/jcp.25995.

Oil-Based or Water-Based Contrast for Hysterosalpingography in Infertile Women

Kim Dreyer, et al, N ENgl J Med, May 18, 2017. DOI: 10.1056/NEJMoa1612337.

Nina Cabezas-Wallscheid, Florian Buettner, Pia Sommerkamp, Daniel Klimmeck, Luisa Ladel, Frederic B. Thalheimer, Daniel Pastor-Flores, Leticia P. Roma, Simon Renders, Petra Zeisberger, Adriana Przybylla, Katharina Schönberger, Roberta Scognamiglio, Sandro Altamura, Carolina M. Florian, Malak Fawaz, Dominik Vonficht, Melania Tesio, Paul Collier, Dinko Pavlinic, Hartmut Geiger, Timm Schroeder, Vladimir Benes, Tobias P. Dick, Michael A. Rieger, Oliver Stegle, Andreas Trumpp. Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy. Cell, 2017; DOI: 10.1016/j.cell.2017.04.018


1.             Sachdev AH, Pimentel M. Gastrointestinal bacterial overgrowth: pathogenesis and clinical significance. Ther Adv Chronic Dis. 2013 Sep;4(5):223-31. 2.             Ghoshal UC, Ghoshal U. Small Intestinal Bacterial Overgrowth and Other Intestinal Disorders. Gastroenterol Clin North Am. 2017 Mar;46(1):103-120.3.             Ghoshal UC, Shukla R, Ghoshal U. Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge between Functional Organic Dichotomy. Gut Liver. 2017 Mar 15;11(2):196-208.4.             Pimentel M. Review article: potential mechanisms of action of rifaximin in the management of irritable bowel syndrome with diarrhoea. Aliment Pharmacol Ther. 2016 Jan;43 Suppl 1:37-49.

  1. Patricio Ibanez MP, Melmed GY, Ippoliti A, Targan SR, Vasiliauskas EA. Fatigue and abdominal bloating predict small intestinal bacterial overgrowth (SIBO) in patients with ulcerative colitis (UC). Gastroenterology. 2008;134:A-350.

6.             Ricci JE Júnior, Chebli LA, et al. Small-Intestinal Bacterial Overgrowth is Associated With Concurrent Intestinal Inflammation But Not With Systemic Inflammation in Crohn’s Disease Patients. J Clin Gastroenterol. 2017 Jan 27.

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8.             Teo M, Chung S, Chitti L, Tran C, Kritas S, Butler R, Cummins A. Small bowel bacterial overgrowth is a common cause of chronic diarrhea. J Gastroenterol Hepatol. 2004 Aug;19(8):904-9.9.             Losurdo G, Marra A, Shahini E, et al. Small intestinal bacterial overgrowth and celiac disease: A systematic review with pooled-data analysis. Neurogastroenterol Motil. 2017 Feb 12.10.         Signoretti M, Stigliano S, Valente R, Piciucchi M, Delle Fave G, Capurso G. Small intestinal bacterial overgrowth in patients with chronic pancreatitis. J Clin Gastroenterol. 2014 Nov-Dec;48 Suppl 1:S52-5. 11.         Therrien A, Bouchard S, Sidani S, et al. Prevalence of Small Intestinal Bacterial Overgrowth among Chronic Pancreatitis Patients: A Case-Control Study. Can J Gastroenterol Hepatol. 2016;2016:7424831.12.         Kim KM, Kim BT, Lee DJ, Park SB, Joo NS, Kim YS, Kim KN. Erosive esophagitis may be related to small intestinal bacterial overgrowth. Scand J Gastroenterol. 2012 May;47(5):493-8.

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24.         Fialho A, Fialho A, Schenone A, Thota P, McCullough A, Shen B. Association between small intestinal bacterial overgrowth and deep vein thrombosis. Gastroenterol Rep (Oxf). 2016 Nov;4(4):299-303.25.         Cheng X, Zhang L, Xie NC, Xu HL, Lian YJ. Association between small-intestinal bacterial overgrowth and deep vein thrombosis in patients with spinal cord injuries. J Thromb Haemost. 2017 Feb;15(2):304-311.26.         Niu XL, Liu L, Song ZX, Li Q, Wang ZH, Zhang JL, Li HH. Prevalence of small intestinal bacterial overgrowth in Chinese patients with Parkinson’s disease. J Neural Transm (Vienna). 2016 Dec;123(12):1381-1386.27.         Zhang Y, Liu G, Duan Y, Han X, Dong H, Geng J. Prevalence of Small Intestinal  Bacterial Overgrowth in Multiple Sclerosis: a Case-Control Study from China. J Neuroimmunol. 2016 Dec 15;301:83-87. 28.         Quigley EM. Small intestinal bacterial overgrowth: what it is and what it is not. Curr Opin Gastroenterol. 2014 Mar;30(2):141-6. 29.         Krajicek EJ, Hansel SL. Small Intestinal Bacterial Overgrowth: A Primary Care Review. Mayo Clin Proc. 2016 Dec;91(12):1828-1833.

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Emily G. Severance et al. Probiotic normalization of Candida albicans in schizophrenia: A randomized, placebo-controlled, longitudinal pilot study. Brain, Behavior, and Immunity, 2017; 62: 41 DOI: 10.1016/j.bbi.2016.11.019.


Emily G Severance et al. Candida albicans exposures, sex specificity and cognitive deficits in schizophrenia and bipolar disorder. npj Schizophrenia, 2016; 2: 16018 DOI: 10.1038/npjschz.2016.18.


Choi JW et al. Kefir prevented excess fat accumulation in diet-induced obese mice. Biosci Biotechnol Biochem. 2017 May; 81(5):958-965. doi: 10.1080/09168451.2016.1258984.

Netusha Thevaranjan et al. Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction. Cell Host & Microbe, 2017; 21 (4): 455 DOI: 10.1016/j.chom.2017.03.002

Vanessa D. de Mello et al. Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study. Scientific Reports, 2017; 7: 46337 DOI: 10.1038/srep46337

Chihaya Yamada et al. Molecular Insight into Evolution of Symbiosis between Breast-Fed Infants and a Member of the Human Gut Microbiome Bifidobacterium longum. Cell Chemical Biology, 2017; DOI: 10.1016/j.chembiol.2017.03.012



Influence of a 10-Day Mimic of Our Ancient Lifestyle on Anthropometrics and Parameters of Metabolism and Inflammation: The “Study of Origin”

Leo Pruimboom, Begoña Ruiz-Núñez, Charles L. Raison, and Frits A. J. Muskiet. BioMed Research International, V 2016 (2016), Article ID 6935123, 9 pages



New Scientist, March 29, 2017.  Chelsea Whyte: Lyme disease is set to explode and we still don’t have a vaccine s


Bret M. Boyd, Julie M. Allen, Nam-phuong Nguyen, Pranjal Vachaspati, Zach Quicksall, Tandy Warnow, Lawrence Mugisha, Kevin P. Johnson, David L. Reed. Primates, lice and bacteria: speciation and genome evolution in the symbionts of hominid lice. Molecular Biology and Evolution, 2017; DOI: 10.1093/molbev/msx117


Setor Kwadzo Kunutsor, Michael Richard Whitehouse, Ashley William Blom, Jari Antero Laukkanen. Low serum magnesium levels are associated with increased risk of fractures: a long-term prospective cohort study. European Journal of Epidemiology, 2017; DOI: 10.1007/s10654-017-0242-2.

Thomas M. Stubbs, Marc Jan Bonder, Anne-Katrien Stark, Felix Krueger, Ferdinand von Meyenn, Oliver Stegle, Wolf Reik. Multi-tissue DNA methylation age predictor in mouse. Genome Biology, 2017; 18 (1) DOI: 10.1186/s13059-017-1203-5 .

Jamshid Tabeshpour, Bibi Marjan Razavi, Hossein Hosseinzadeh. Effects of Avocado (Persea americana ) on Metabolic Syndrome: A Comprehensive Systematic Review. Phytotherapy Research, 2017; DOI: 10.1002/ptr.5805.

Yung-Chih Chen, Rebecca L. Travers, Jean-Philippe Walhin, Javier T. Gonzalez, Francoise Koumanov, James A. Betts, Dylan Thompson. Feeding Influences Adipose Tissue Responses To Exercise In Overweight Men. American Journal of Physiology – Endocrinology And Metabolism, 2017; ajpendo.00006.2017 DOI: 10.1152/ajpendo.00006.2017.

Lamb DJ1, Reeves GL, Taylor A, Ferns GA.
Dietary copper supplementation reduces atherosclerosis in the cholesterol-fed rabbit. Atherosclerosis. 1999 Sep;146(1):33-43.

William G. Elder, Niki Munk, Margaret M. Love, Geza G. Bruckner, Kathryn E. Stewart, Kevin Pearce. Real-World Massage Therapy Produces Meaningful Effectiveness Signal for Primary Care Patients with Chronic Low Back Pain: Results of a Repeated Measures Cohort Study. Pain Medicine, 2017; DOI: 10.1093/pm/pnw347

Omar M. El-Halfawy, Javier Klett, Rebecca J. Ingram, Slade A. Loutet, Michael E. P. Murphy, Sonsoles Martín-Santamaría, Miguel A. Valvano. Antibiotic Capture by Bacterial Lipocalins Uncovers an Extracellular Mechanism of Intrinsic Antibiotic Resistance. mBio, 2017; 8 (2): e00225-17 DOI: 10.1128/mBio.00225-17.

Daniel Brugger, Wilhelm M Windisch. Short-Term Subclinical Zinc Deficiency in Weaned Piglets Affects Cardiac Redox Metabolism and Zinc Concentration. The Journal of Nutrition, 2017; 147 (4): 521 DOI: 10.3945/jn.116.240804

Zinc and the eye:
1 “Zinc,” June 2015,

2 “Review: Zinc’s Functional Significance in the Vertebrate Retina,” July 2014,

3 “Study Shows New Role of Zinc in Optic Nerve Injury,” January 2017,

4 “Mobile Zinc Increases Rapidly in the Retina After Optic Nerve Injury and Regulates Ganglion Cell Survival and Optic Nerve Regeneration,” January 2017,

Eveliina Munukka, Anniina Rintala, Raine Toivonen, Matts Nylund, Baoru Yang, Anna Takanen, Arno Hänninen, Jaana Vuopio, Pentti Huovinen, Sirpa Jalkanen, Satu Pekkala. Faecalibacterium prausnitzii treatment improves hepatic health and reduces adipose tissue inflammation in high-fat fed mice. The ISME Journal, 2017; DOI: 10.1038/ismej.2017.24

Joshua D. Schoenfeld, et al. O 2 − and H 2 O 2 -Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. Cancer Cell, 2017; DOI: 10.1016/j.ccell.2017.02.018

April 2017

IHCAN April references



Jia Zhong et al. B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial. PNAS 2017 ; published ahead of print March 13, 2017,

HELEN MONK on BANT Supervision

  1. Despenser S (2011) What is Supervision? British Association for Counselling and Psychotherapy (BACP).
  2. Hawkins P Shohet R and Hawkins R (2012) Supervision In The Helping Professions Open University Press; 4th edition.


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Gloria Bonuccelli, Ernestina Marianna De Francesco, Rianne de Boer, Herbert B. Tanowitz, Michael P. Lisanti. NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Identification of Vitamin C and CAPE as natural products targeting “stemness”. Oncotarget, 2015; DOI: 10.18632/oncotarget.15400.

Hillard Kaplan, Randall C Thompson, Benjamin C Trumble, L Samuel Wann, Adel H Allam, Bret Beheim, Bruno Frohlich, M Linda Sutherland, James D Sutherland, Jonathan Stieglitz, Daniel Eid Rodriguez, David E Michalik, Chris J Rowan, Guido P Lombardi, Ram Bedi, Angela R Garcia, James K Min, Jagat Narula, Caleb E Finch, Michael Gurven, Gregory S Thomas. Coronary atherosclerosis in indigenous South American Tsimane: a cross-sectional cohort study. The Lancet, 2017; DOI: 10.1016/S0140-6736(17)30752-3.

Mark Jones, Susan Tett, Geeske M. E. E. Peeters, Gita D. Mishra, Annette Dobson. New-Onset Diabetes After Statin Exposure in Elderly Women: The Australian Longitudinal Study on Women’s Health. Drugs & Aging, 2017; 34 (3): 203 DOI: 10.1007/s40266-017-0435-0.

Emma Lefrançais, Guadalupe Ortiz-Muñoz, Axelle Caudrillier, Beñat Mallavia, Fengchun Liu, David M. Sayah, Emily E. Thornton, Mark B. Headley, Tovo David, Shaun R. Coughlin, Matthew F. Krummel, Andrew D. Leavitt, Emmanuelle Passegué, Mark R. Looney. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature, 2017; DOI: 10.1038/nature21706

Didier Ndeh, Artur Rogowski, Alan Cartmell, Ana S. Luis, Arnaud Baslé, Joseph Gray, Immacolata Venditto, Jonathon Briggs, Xiaoyang Zhang, Aurore Labourel, Nicolas Terrapon, Fanny Buffetto, Sergey Nepogodiev, Yao Xiao, Robert A. Field, Yanping Zhu, Malcolm A. O’Neill, Breeanna R. Urbanowicz, William S. York, Gideon J. Davies, D. Wade Abbott, Marie-Christine Ralet, Eric C. Martens, Bernard Henrissat, Harry J. Gilbert. Complex pectin metabolism by gut bacteria reveals novel catalytic functions. Nature, 2017; DOI: 10.1038/nature21725.

Simon Nicolas, Vincent Blasco‐Baque, Audren Fournel, Jerome Gilleron, Pascale Klopp, Aurelie Waget, Franck Ceppo, Alysson Marlin, Roshan Padmanabhan, Jason S Iacovoni, François Tercé, Patrice D Cani, Jean‐François Tanti, Remy Burcelin, Claude Knauf, Mireille Cormont, Matteo Serino. Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism. Molecular Systems Biology, 2017; 13 (3): 921 DOI: 10.15252/msb.20167356

Stuart G. Snowden, Amera A. Ebshiana, Abdul Hye, Yang An, Olga Pletnikova, Richard O’Brien, John Troncoso, Cristina Legido-Quigley, Madhav Thambisetty. Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study. PLOS Medicine, 2017; 14 (3): e1002266 DOI: 10.1371/journal.pmed.1002266

Stephanie Vuillermot, Wei Luan, Urs Meyer, Darryl Eyles. Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation. Molecular Autism, 2017; 8 (1) DOI: 10.1186/s13229-017-0125-0

Tatiana E. Salazar et al, Electroacupuncture Promotes CNS-Dependent Release of Mesenchymal Stem Cells. STEM CELLS, 2017; DOI: 10.1002/stem.2613

March 2017

BEN BROWN Detoxification

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Nicole Paulin, Yvonne Döring, Sander Kooijman, Xavier Blanchet, Joana R. Viola, Renske de Jong, Manuela Mandl, Jeffrey Hendrikse, Maximilian Schiener, Philipp von Hundelshausen, Anja Vogt, Christian Weber, Khalil Bdeir, Susanna M. Hofmann, Patrick C.N. Rensen, Maik Drechsler, Oliver Soehnlein. Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance. EBioMedicine, 2017; DOI: 10.1016/j.ebiom.2017.01.006

Maret G Traber, Eunice Mah, Scott W Leonard, Gerd Bobe, Richard S Bruno. Metabolic syndrome increases dietary α-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial. The American Journal of Clinical Nutrition, 2017; ajcn138495 DOI: 10.3945/ajcn.116.138495.

Martineau AR et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 2017; 356 doi:

Naama Geva-Zatorsky, Esen Sefik, Lindsay Kua, Lesley Pasman, Tze Guan Tan, Adriana Ortiz-Lopez, Tsering Bakto Yanortsang, Liang Yang, Ray Jupp, Diane Mathis, Christophe Benoist, Dennis L. Kasper. Mining the Human Gut Microbiota for Immunomodulatory Organisms. Cell, 2017; DOI: 10.1016/j.cell.2017.01.022

Monica Viladomiu, Charles Kivolowitz, Ahmed Abdulhamid, Belgin Dogan, Daniel Victorio, Jim G. Castellanos, Viola Woo, Fei Teng, Nhan L. Tran, Andrew Sczesnak, Christina Chai, Myunghoo Kim, Gretchen E. Diehl, Nadim J. Ajami, Joseph F. Petrosino, Xi K. Zhou, Sergio Schwartzman, Lisa A. Mandl, Meira Abramowitz, Vinita Jacob, Brian Bosworth, Adam Steinlauf, Ellen J. Scherl, Hsin-Jung Joyce Wu, Kenneth W. Simpson, Randy S. Longman. IgA-coated E. coli enriched in Crohn’s disease spondyloarthritis promote T H 17-dependent inflammation. Science Translational Medicine, 2017; 9 (376): eaaf9655 DOI: 10.1126/scitranslmed.aaf9655

J. Firth, B. Stubbs, J. Sarris, S. Rosenbaum, S. Teasdale, M. Berk, A. R. Yung. The effects of vitamin and mineral supplementation on symptoms of schizophrenia: a systematic review and meta-analysis. Psychological Medicine, 2017; 1 DOI: 10.1017/S0033291717000022.

Min Wei, Sebastian Brandhorst, Mahshid Shelehchi, Hamed Mirzaei, Chia Wei Cheng, Julia Budniak, Susan Groshen, Wendy J. Mack, Esra Guen, Stefano Di Biase, Pinchas Cohen, Todd E. Morgan, Tanya Dorff, Kurt Hong, Andreas Michalsen, Alessandro Laviano, Valter D. Longo. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Science Translational Medicine, 2017; 9 (377): eaai8700 DOI: 10.1126/scitranslmed.aai8700.

Julia H. Kreznar, Mark P. Keller, Lindsay L. Traeger, Mary E. Rabaglia, Kathryn L. Schueler, Donald S. Stapleton, Wen Zhao, Eugenio I. Vivas, Brian S. Yandell, Aimee Teo Broman, Bruno Hagenbuch, Alan D. Attie, Federico E. Rey. Host Genotype and Gut Microbiome Modulate Insulin Secretion and Diet-Induced Metabolic Phenotypes. Cell Reports, 2017; 18 (7): 1739 DOI: 10.1016/j.celrep.2017.01.062.

Robert S. Thompson, Rachel Roller, Agnieszka Mika, Benjamin N. Greenwood, Rob Knight, Maciej Chichlowski, Brian M. Berg, Monika Fleshner. Dietary Prebiotics and Bioactive Milk Fractions Improve NREM Sleep, Enhance REM Sleep Rebound and Attenuate the Stress-Induced Decrease in Diurnal Temperature and Gut Microbial Alpha Diversity. Frontiers in Behavioral Neuroscience, 2017; 10 DOI: 10.3389/fnbeh.2016.00240.

Nina Kim, Thomas H. Thatcher, Patricia J. Sime, Richard P. Phipps. Corticosteroids inhibit anti-IgE activities of specialized proresolving mediators on B cells from asthma patients. JCI Insight, 2017; 2 (3) DOI: 10.1172/jci.insight.88588

Tiffany Zee, Neelanjan Bose, Jarcy Zee, Jennifer N Beck, See Yang, Jaspreet Parihar, Min Yang, Sruthi Damodar, David Hall, Monique N O’Leary, Arvind Ramanathan, Roy R Gerona, David W Killilea, Thomas Chi, Jay Tischfield, Amrik Sahota, Arnold Kahn, Marshall L Stoller, Pankaj Kapahi. α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria. Nature Medicine, 2017; DOI: 10.1038/nm.4280

Zhongyuan Guo, Nicole J. Martucci, Fabiola Moreno-Olivas, Elad Tako, Gretchen J. Mahler. Titanium dioxide nanoparticle ingestion alters nutrient absorption in an in vitro model of the small intestine. NanoImpact, 2017; 5: 70 DOI: 10.1016/j.impact.2017.01.002.

Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon

Sarah Bettini et al. Scientific Reports 7, Article number: 40373 (2017). doi:10.1038/srep40373.

Pete A. Williams, Jeffrey M. Harder, Nicole E. Foxworth, Kelly E. Cochran, Vivek M. Philip, Vittorio Porciatti, Oliver Smithies, Simon W. M. John. Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. Science, 2017; 355 (6326): 756 DOI: 10.1126/science.aal0092.

An Exploratory Investigation of Endotoxin Levels in Novice Long Distance Triathletes, and the Effects of a Multi-Strain Probiotic/Prebiotic, Antioxidant Intervention

Justin D. Roberts et al. Nutrients 2016, 8(11), 733; doi:10.3390/nu8110733.

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irritable bowel syndrome: A systematic review. Gut. 2010 Mar; 59(3):325–32.

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prebiotic on faecal microbiota and symptoms in irritable bowel syndrome. Aliment Pharmacology and Therapeutics. 2009 Mar; 29(5):508–18.

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Temporal analysis reveals individual and common core and relation to intestinal symptoms. PLoS One, 2011 Jul; 6(7):e23035.

  1. 1 Baştür, A., et al. Efficacy of synbiotic, probiotic, and prebiotic treatments for

irritable bowel syndrome in children: A randomized controlled

trial. Turk J Gastroenterol. 2016 Sep; 27(5):439-443.


  1. PHE/RIPL website:
    2. Stevenson B. Variable VlsE Is Critical for Host Reinfection by the Lyme Disease Spirochete. PLoS One. 2013, 8(4)
    3. Meriläinen L et al. Morphological and biochemical features of Borrelia burgdorferi pleomorphic forms. Microbiology. 2015 Mar;161(Pt 3):516-27.
    4. Sapi E et al. Characterization of Biofilm Formation by Borrelia burgdorferi In Vitro. PLoS One. 2013 7(10)
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    6. Stricker RB et al. Lyme disease: the promise of Big Data, companion diagnostics and precision medicine. Infect Drug Resist. 2016;9:215-219
    7. Lehman PV et al. Unique Strengths of ELISPOT for T Cell Diagnostics. In: Kalyuzhny AE. Handbook of ELISPOT: Methods and Protocols, Methods in Molecular Biology, Vol. 792. 2nd Ed: Springer; 2012: 3-23.
    8. Stricker RB and Winger EE. Decreased CD57 Lymphocyte Subset in Patients with Chronic Lyme Disease. Immunology Letters, 2001;76, 43-48.

LEARNING ZONE – the Sensitivity Gene

* The January 2015 Duke University study, “Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial,” was published in the Journal of Policy Analysis and Management.
*Benedicte Meyer et al, Maintenance of Chronic Fatigue Syndrome (CFS) in Young CFS Patients Is Associated with the 5-HTTLPR and SNP rs25531 A > G Genotype. PLOS One,  2015,

* Felitti VJ, Anda RF et al. Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults: The Adverse Childhood Experiences (ACE) Study. Am J Preventive Med May 1998, 14, 4,: 245–58.

* For The Sensitivity Hypothesis, Dandelion and Orchid Children, see research by Bruce Ellis  University of Arizona, and W Thomas Boyce  University of British Columbia, for example “Biological sensitivity to context: I. An evolutionary–developmental theory of the origins and functions of stress reactivity” in Development and Psychopathology

17, 2005, 271–301. DOI: 10.1017/S095457940505014.

* Childhood Disrupted: How Your Biography Becomes Your Biology and How You Can Heal, by Donna Jackson Nakazawa:

* GSC – Genetically Sensitive Client- Chrysalis Effect Specialist Practitioner Training Elaine Wilkins:


Isabel Garcia-Perez, Joram M Posma, Rachel Gibson, Edward S Chambers, Tue H Hansen, Henrik Vestergaard, Torben Hansen, Manfred Beckmann, Oluf Pedersen, Paul Elliott, Jeremiah Stamler, Jeremy K Nicholson, John Draper, John C Mathers, Elaine Holmes, Gary Frost. Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial. The Lancet Diabetes & Endocrinology, 2017; DOI: 10.1016/S2213-8587(16)30419-3

A Meta-Analysis of Randomized Controlled Trials and Prospective Cohort Studies of Eicosapentaenoic and Docosahexaenoic Long-Chain Omega-3 Fatty Acids and Coronary Heart Disease Risk. Dominik D. Alexander et al. Open Access . DOI:

Mayo Clinic Proceedings, January 2017, Volume 92, Issue 1, Pages 15–29.

January 2017

Arch Intern Med. 1999 Sep 27;159(17):1981-7.). Homeopathy re-revisited: is homeopathy compatible with biomedical observations? Eskinazi D.

Saha, SK. et al. Ultrahighly diluted plant extracts of Hydrastis canadensis and Marsdenia condurango induce epigenetic modifications and alter gene expression profiles in HeLa cells in vitroJ. Integr. Med13, 400–411 (2015).

Randomised placebo-controlled trials of individualised homeopathic treatment: systematic review and meta-analysis. Robert T Mathie et al. Systematic Rev, 2014, 3:142. DOI: 10.1186/2046-4053-3-142.

Cell, Ocampo et al.: “In vivo amelioration of age-associated hallmarks by partial reprogramming.” DOI: 10.1016/j.cell.2016.11.052 ,


Diabetes Res Clin Pract. 2009 Feb;83(2):e40-2. doi: 10.1016/j.diabres.2008.11.014. Epub 2008 Dec 23. Immediate and long-term effects of glucomannan on total ghrelin and leptin in type 2 diabetes mellitus. Chearskul S1, Kriengsinyos W, Kooptiwut S, Sangurai S, Onreabroi S, Churintaraphan M, Semprasert N, Nitiyanant W.



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Additional story:
Antonio Gonzalez, Embriette Hyde, Naseer Sangwan, Jack A. Gilbert, Erik Viirre, Rob Knight. Migraines Are Correlated with Higher Levels of Nitrate-, Nitrite-, and Nitric Oxide-Reducing Oral Microbes in the American Gut Project Cohort. mSystems, October 2016 DOI: 10.1128/mSystems.00105-16

Nutritional approaches to combat oxidative stress in Alzheimer’s disease. Butterfield D, Castegna A, Pocernich C, Drake J, Scapagnini G, Calabrese V. J Nutr Biochem. 2002 Aug;13(8):444.

Influence of apple polyphenols on inflammatory gene expression. Jung M, Triebel S, Anke T, Richling E, Erkel G. Mol Nutr Food Res. 2009 Oct;53(10):1263-80. doi: 10.1002/mnfr.200800575.

Christopher T. Ford, Siân Richardson, Francis McArdle, Silvina B. Lotito, Alan Crozier, Anne McArdle, Malcolm J. Jackson. Identification of (poly)phenol treatments that modulate the release of pro-inflammatory cytokines by human lymphocytes. British Journal of Nutrition, 2016; 115 (10): 1699 DOI: 10.1017/S0007114516000805

  1. Zamora-Ros, M. Rabassa, A. Cherubini, M. Urpi-Sarda, S. Bandinelli, L. Ferrucci, C. Andres-Lacueva. High Concentrations of a Urinary Biomarker of Polyphenol Intake Are Associated with Decreased Mortality in Older Adults. Journal of Nutrition, 2013; 143 (9): 1445 DOI: 10.3945/jn.113.177121

Harri Hemil. Vitamin E and the risk of pneumonia: using the I²-statistic to quantify heterogeneity within a controlled trial. British Journal of Nutrition, 2016; 1 DOI: 10.1017/S0007114516003408.

Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 – Fields of Precision Nutrition

J Nutrigenet Nutrigenomics 2016;9:12-27, (DOI:10.1159/000445350)

Fulltext PDF (674 Kb) Free Access at


From Sample to Multi-Omics Conclusions in under 48 Hours. Robert A. Quinn, Jose A. Navas-Molina, Embriette R. Hyde, Se Jin Song, Yoshiki Vázquez-Baeza, Greg Humphrey, James Gaffney, Jeremiah J. Minich, Alexey V. Melnik, Jakob Herschend, Jeff DeReus, Austin Durant, Rachel J. Dutton, Mahdieh Khosroheidari, Clifford Green, Ricardo da Silva, Pieter C. Dorrestein, Rob Knight

Jack A. Gilbert, Editor. mSystems, 2016: DOI: 10.1128/mSystems.00038-16.

Timothy R. Sampson et al. Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease. Cell, December 2016 DOI: 10.1016/j.cell.2016.11.018.

Christoph A. Thaiss et al. Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations. Cell, December 2016 DOI: 10.1016/j.cell.2016.11.003

Diet-Microbiome Interactions in Health Are Controlled by Intestinal Nitrogen Source Constraints. Andrew J. Holmes et al. Cell Metabolism. In Press. available online 23 November 2016.

Francesco Foroni, Giulio Pergola, Raffaella Ida Rumiati. Food colour is in the eye of the beholder: the role of human trichromatic vision in food evaluation. Scientific Reports, 2016; 6: 37034 DOI: 10.1038/srep37034

Dagfinn Aune, NaNa Keum, Edward Giovannucci, Lars T. Fadnes, Paolo Boffetta, Darren C. Greenwood, Serena Tonstad, Lars J. Vatten, Elio Riboli, Teresa Norat. Nut consumption and risk of cardiovascular disease, total cancer, all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective studies. BMC Medicine, 2016; 14 (1) DOI: 10.1186/s12916-016-0730-3

  1. Zelano, H. Jiang, G. Zhou, N. Arora, S. Schuele, J. Rosenow, J. A. Gottfried. Nasal Respiration Entrains Human Limbic Oscillations and Modulates Cognitive Function. Journal of Neuroscience, 2016; 36 (49): 12448 DOI: 10.1523/JNEUROSCI.2586-16.2016

* Video:

Candyce H. Kroenke, Yvonne L. Michael, Elizabeth M. Poole, Marilyn L. Kwan, Sarah Nechuta, Eric Leas, Bette J. Caan, John Pierce, Xiao-Ou Shu, Ying Zheng, Wendy Y. Chen. Postdiagnosis social networks and breast cancer mortality in the After Breast Cancer Pooling Project. Cancer, 2016; DOI: 10.1002/cncr.30440.

  1. Gunness, J. Michiels, L. Vanhaecke, S. De Smet, O. Kravchuk, A. Van de Meene, M. J. Gidley. Reduction in circulating bile acid and restricted diffusion across the intestinal epithelium are associated with a decrease in blood cholesterol in the presence of oat  -glucan. The FASEB Journal, 2016; 30 (12): 4227 DOI: 10.1096/fj.201600465R.

Inmaculada Moreno, Francisco M. Codoñer, Felipe Vilella, Diana Valbuena, Juan F. Martinez-Blanch, Jorge Jimenez-Almazán, Roberto Alonso, Pilar Alamá, Jose Remohí, Antonio Pellicer, Daniel Ramon, Carlos Simon. Evidence that the endometrial microbiota has an effect on implantation success or failure. American Journal of Obstetrics and Gynecology, 2016; 215 (6): 684 DOI: 10.1016/j.ajog.2016.09.075

Haiqiu Huang, Xiaojing Jiang, Zhenlei Xiao, Lu Yu, Quynhchi Pham, Jianghao Sun, Pei Chen, Wallace Yokoyama, Liangli Lucy Yu, Yaguang Sunny Luo, Thomas T. Y. Wang. Red Cabbage Microgreens Lower Circulating Low-Density Lipoprotein (LDL), Liver Cholesterol, and Inflammatory Cytokines in Mice Fed a High-Fat Diet. Journal of Agricultural and Food Chemistry, 2016; 64 (48): 9161 DOI: 10.1021/acs.jafc.6b03805

December 2016


Giannis Koukkidis, Richard Haigh, Natalie Allcock, Suzanne Jordan, and Primrose Freestone. Salad leaf juices enhance Salmonella growth, fresh produce colonisation and virulence. Applied and Environmental Microbiology, November 2016 DOI: 10.1128/AEM.02416-16
Cheng-Shiuan Lee, Molly E. Lutcavage, Emily Chandler, Daniel J. Madigan, Robert M. Cerrato, Nicholas S. Fisher. Declining Mercury Concentrations in Bluefin Tuna Reflect Reduced Emissions to the North Atlantic Ocean. Environmental Science & Technology, 2016; DOI: 10.1021/acs.est.6b04328

Lei Yin, Kevin Yu, Simon Lin, Xiao Song, Xiaozhong Yu. Associations of blood mercury, inorganic mercury, methyl mercury and bisphenol A with dental surface restorations in the U.S. population, NHANES 2003–2004 and 2010–2012. Ecotoxicology and Environmental Safety, 2016; 134: 213 DOI: 10.1016/j.ecoenv.2016.09.001

Dr Mark Hyman on mercury:


Elmira Akbari, Zatollah Asemi, Reza Daneshvar Kakhaki, Fereshteh Bahmani, Ebrahim Kouchaki, Omid Reza Tamtaji, Gholam Ali Hamidi, Mahmoud Salami. Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer’s Disease: A Randomized, Double-Blind and Controlled Trial. Frontiers in Aging Neuroscience, 2016; 8 DOI: 10.3389/fnagi.2016.00256

BEN BROWN Migraine

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E. F. G. Naninck, J. E. Oosterink, K.-Y. Yam, L. P. de Vries, H. Schierbeek, J. B. van Goudoever, R.-N. Verkaik-Schakel, J. A. Plantinga, T. Plosch, P. J. Lucassen, A. Korosi. Early micronutrient supplementation protects against early stress-induced cognitive impairments. The FASEB Journal, 2016; DOI: 10.1096/fj.201600834R

Sarkar et al. Psychobiotics and the Manipulation of Bacteria-Brain Signals. Trends in Neurosciences, October 2016 DOI: 10.1016/j.tins.2016.09.002


PLoS One. 2016 Oct 31;11(10):e0165378. doi: 10.1371/journal.pone.0165378. eCollection 2016. Third Exposure to a Reduced Carbohydrate Meal Lowers Evening Postprandial Insulin and GIP Responses and HOMA-IR Estimate of Insulin Resistance. Lin PJ1, Borer KT1.

Giles Major et al. Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-related Symptoms in Individuals with Irritable Bowel Syndrome, Gastroenterology (2016). DOI: 10.1053/j.gastro.2016.09.062

  1. Pegorie, D.W. Denning, W. Welfare. Estimating the burden of invasive and serious fungal disease in the United Kingdom. Journal of Infection, 2016; DOI: 10.1016/j.jinf.2016.10.005
  1. Ren, C. Luo, Y. Feng, X. Yao, Z. Shi, F. Liang, J. X. Kang, J.-B. Wan, Z. Pei, H. Su. Omega-3 polyunsaturated fatty acids promote amyloid-  clearance from the brain through mediating the function of the glymphatic system. The FASEB Journal, 2016; DOI: 10.1096/fj.201600896
  2. Yuan, G. Wei, Y. You, Y. Huang, H. J. Lee, M. Dong, J. Lin, T. Hu, H. Zhang, C. Zhang, H. Zhou, R. Ye, X. Qi, B. Zhai, W. Huang, S. Liu, W. Xie, Q. Liu, X. Liu, C. Cui, D. Li, J. Zhan, J. Cheng, Z. Yuan, W. Jin. Rutin ameliorates obesity through brown fat activation. The FASEB Journal, 2016; DOI: 10.1096/fj.201600459RR

Harri Hemil�. Vitamin E and the risk of pneumonia: using the I²-statistic to quantify heterogeneity within a controlled trial. British Journal of Nutrition, 2016; 1 DOI: 10.1017/S0007114516003408.

November 2016


Mi-Sung Kim, Sarah A. Krawczyk, Ludivine Doridot, Alan J. Fowler, Jennifer X. Wang, Sunia A. Trauger, Hye-Lim Noh, Hee Joon Kang, John K. Meissen, Matthew Blatnik, Jason K. Kim, Michelle Lai, Mark A. Herman. ChREBP regulates fructose-induced glucose production independently of insulin signaling. Journal of Clinical Investigation, 2016; DOI: 10.1172/JCI81993

Zaidi et al. Vitamin D Deficiency in Medical Inpatients: A Retrospective Study of Implications of Untreated Versus Treated Deficiency. Nutrition and Metabolic Insights 2016:9 65–69 doi:10.4137/NMI.S33747.

Ryan Hutchinson, Abdulhadi Akhtar, Justin Haridas, Deepa Bhat, Claus Roehrborn, Yair Lotan. Testing and referral patterns in the years surrounding the US Preventive Services Task Force recommendation against prostate-specific antigen screening. Cancer, 2016; DOI: 10.1002/cncr.30330

Agatha A. van der Klaauw, Julia M. Keogh, Elana Henning, Cheryl Stephenson, Sarah Kelway, Victoria M. Trowse, Naresh Subramanian, Stephen O’Rahilly, Paul C. Fletcher, I. Sadaf Farooqi. Divergent effects of central melanocortin signalling on fat and sucrose preference in humans. Nature Communications, 2016; 7: 13055 DOI: 10.1038/NCOMMS13055

* Denis Campbell10/20/2016.


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4.             Kou MC, Chiou SY, Weng CY, Wang L, Ho CT, Wu MJ. Curcuminoids distinctly exhibit antioxidant activities and regulate expression of scavenger receptors and heme oxygenase-1. Mol Nutr Food Res. 2013 Sep;57(9):1598-610.

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Milda Stuknytė, Margherita Maggioni, Stefano Cattaneo, Paola De Luca, Amelia Fiorilli, Anita Ferraretto, Ivano De Noni. Release of wheat gluten exorphins A5 and C5 during in vitro gastrointestinal digestion of bread and pasta and their absorption through an in vitro model of intestinal epithelium. Food Research International, 2015; 72: 208 DOI: 10.1016/j.foodres.2015.04.002.

Matthew Weiser, Jeremy M Simon, Bharati Kochar, Adelaide Tovar, Jennifer W Israel, Adam Robinson, Gregory R Gipson, Matthew S Schaner, Hans H Herfarth, R Balfour Sartor, Dermot P B McGovern, Reza Rahbar, Timothy S Sadiq, Mark J Koruda, Terrence S Furey, Shehzad Z Sheikh. Molecular classification of Crohn’s disease reveals two clinically relevant subtypes. Gut, October 2016 DOI: 10.1136/gutjnl-2016-312518.

Antonio Gonzalez, Embriette Hyde, Naseer Sangwan, Jack A. Gilbert, Erik Viirre, Rob Knight. Migraines Are Correlated with Higher Levels of Nitrate-, Nitrite-, and Nitric Oxide-Reducing Oral Microbes in the American Gut Project Cohort. mSystems, October 2016 DOI: 10.1128/mSystems.00105-16.




Turmeric tea study:
Dias, I., Ademowo, O., Newey, E. and Griffiths, H. (2015). The Nrf2-ARE activation protect neurones against oxidative stress. Free Radical Biology and Medicine, 86, pp.S30-S31.
Hawkey, C. (2001). COX-1 and COX-2 inhibitors. Best Practice & Research Clinical Gastroenterology, 15(5), pp.801-820.
Lee, J. (2005). Nrf2, a multi-organ protector? The FASEB Journal, 19(9), pp.1061-1066.
Aggarwal B.B, Ichikawa H., Garodia P., Weerasinghe P., Sethi G., Bhatt I.D., Pandey M.K., Shishodia S., Nair M.G. From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer. Expert Opin Ther Targets 2006;10(1):87-118.
Aggarwal B.B., Sundaram C., Malani N., Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol. 2007;595:1-75.
Aggarwal B.B., Yuan W., Li S., Gupta S.C. Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric. Mol Nutr Food Res. 2013;57(9):1529-42.
Potential role of herbal remedies in stem cell therapy: proliferation and differentiation of human mesenchymal stromal cells. Vindya Lankika Udalamaththa, Chanika Dilumi Jayasinghe and Preethi Vidya Udagama. Stem Cell Research & Therapy2016,7:110. DOI: 10.1186/s13287-016-0366-4.

L.N. Yelland, B.J. Gajewski, J. Colombo, R.A. Gibson, M. Makrides, S.E. Carlson. Predicting the effect of maternal docosahexaenoic acid (DHA) supplementation to reduce early preterm birth in Australia and the United States using results of within country randomized controlled trials. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2016; 112: 44 DOI: 10.1016/j.plefa.2016.08.007

Cherrie L. Small, Lydia Xing, Joseph B. McPhee, Hong T. Law, Brian K. Coombes. Acute Infectious Gastroenteritis Potentiates a Crohn’s Disease Pathobiont to Fuel Ongoing Inflammation in the Post-Infectious Period. PLOS Pathogens, 2016; 12 (10): e1005907 DOI: 10.1371/journal.ppat.1005907

Malgorzata Dobosz-Bartoszek, Mark H. Pinkerton, Zbyszek Otwinowski, Srinivas Chakravarthy, Dieter Söll, Paul R. Copeland, Miljan Simonović. Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation. Nature Communications, 2016; 7: 12941 DOI: 10.1038/ncomms12941

Shu G. Chen, Vilius Stribinskis, Madhavi J. Rane, Donald R. Demuth, Evelyne Gozal, Andrew M. Roberts, Rekha Jagadapillai, Ruolan Liu, Kyonghwan Choe, Bhooma Shivakumar, Francheska Son, Shunying Jin, Richard Kerber, Anthony Adame, Eliezer Masliah, Robert P. Friedland. Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans. Scientific Reports, 2016; 6: 34477 DOI: 10.1038/srep34477.

Madhusudana Rao Chikka, Charumathi Anbalagan, Katherine Dvorak, Kyle Dombeck, Veena Prahlad. The Mitochondria-Regulated Immune Pathway Activated in the C. elegans Intestine Is Neuroprotective. Cell Reports, 2016; 16 (9): 2399 DOI: 10.1016/j.celrep.2016.07.077

Shiran Salomon-Zimri, Micaela Johanna Glat, Yael Barhum, Ishai Luz, Anat Boehm-Cagan, Ori Liraz, Tali Ben-Zur, Daniel Offen, Daniel M. Michaelson. Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment. Journal of Alzheimer’s Disease, Volume 53, Number 4, 2016; Pages 1443-1458.

Marc A. Mitchell, David D. Wartinger. Validation of a Functional Pyelocalyceal Renal Model for the Evaluation of Renal Calculi Passage While Riding a Roller Coaster. The Journal of the American Osteopathic Association, 2016; 116 (10): 647 DOI: 10.7556/jaoa.2016.128

Michelle Beaumont, Julia K. Goodrich, Matthew A. Jackson, Idil Yet, Emily R. Davenport, Sara Vieira-Silva, Justine Debelius, Tess Pallister, Massimo Mangino, Jeroen Raes, Rob Knight, Andrew G. Clark, Ruth E. Ley, Tim D. Spector, Jordana T. Bell. Heritable components of the human fecal microbiome are associated with visceral fat. Genome Biology, 2016; 17 (1) DOI: 10.1186/s13059-016-1052-7.

Joseph P Zackular, Jessica L Moore, Ashley T Jordan, Lillian J Juttukonda, Michael J Noto, Maribeth R Nicholson, Jonathan D Crews, Matthew W Semler, Yaofang Zhang, Lorraine B Ware, M Kay Washington, Walter J Chazin, Richard M Caprioli, Eric P Skaar. Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection. Nature Medicine, 2016; DOI: 10.1038/nm.4174.

Jian Zhen Ou, Jeremy J. Cottrell, Nam Ha, Naresh Pillai, Chu K. Yao, Kyle J. Berean, Stephanie A. Ward, Danilla Grando, Jane G. Muir, Christopher J. Harrison, Udani Wijesiriwardana, Frank R. Dunshea, Peter R. Gibson, Kourosh Kalantar-zadeh. Potential of in vivo real-time gastric gas profiling: a pilot evaluation of heat-stress and modulating dietary cinnamon effect in an animal model. Scientific Reports, 2016; 6: 33387 DOI: 10.1038/srep33387.

Somadina Emineke, Alan J Cooper, Sarah Fouch, Brian R Birch, Bashir A Lwaleed. Diluted honey inhibits biofilm formation: potential application in urinary catheter management? Journal of Clinical Pathology, 2016; jclinpath-2015-203546 DOI: 10.1136/jclinpath-2015-203546




October 2016



2011 PACE paper in The Lancet:
PACE authors’ new analyses:…otocol_based_analysis_final_8th_Sept_2016.pdf.

Robert K. Naviaux et al. Metabolic features of chronic fatigue syndrome. PNAS 2016, vol. 113: 37, E5472–E5480. doi: 10.1073/pnas.1607571113.

Robert K. Naviaux, Metabolic features of the cell danger response. Mitochondrion, Volume 16, May 2014, Pages 7–17.


Castro-Marrero Jesús, Cordero Mario D., Segundo María José, Sáez-Francàs Naia, Calvo Natalia, Román-Malo Lourdes, Aliste Luisa, Fernández de Sevilla Tomás, and Alegre José.

Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in Chronic Fatigue Syndrome? Antioxidants & Redox Signaling. March 10, 2015, 22(8): 679-685. doi:10.1089/ars.2014.6181.

Cannabidiol Reduces The Anxiety Induced By Simulated Public Speaking In Treatment-Naïve Social Phobia Patients”. MM Bergamaschi, Department of Neuroscience and Behavior, School of Medicine of Ribeirão Preto, University of São Paulo, SP, Brazil.

Neuropsychopharmacology, May 2011

“Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing”. P Fusar-Poli, Neuroimaging Section, Division of Psychological Medicine, Institute of Psychiatry, London. Archives of General Psychiatry, January 2009.


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IHCAN AUGUST references


SACN vitamin D and health report, from

Public Health England

First published: 21 July 2016

Part of: SACN: reports and position statements and Obesity and healthy eating The Scientific Advisory Committee on Nutrition (SACN) recommendations on vitamin D:

US statistics:

Nahin RL, Barnes PM, Stussman BJ. Expenditures on complementary health approaches: United States, 2012. (433KB PDF) National Health Statistics Reports. Hyattsville, MD: National Center for Health Statistics. 2016.

ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies

Liana C. Del Gobbo et al. JAMA Intern Med. Published online June 27, 2016. doi:10.1001/jamainternmed.2016.2925


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Further reading suggested by Dr Christen Rune Stensvold, PhD (

Pepper, J., & Rosenfeld, S. (2012). The emerging medical ecology of the human gut microbiome Trends in Ecology & Evolution, 27 (7), 381-384 DOI: 10.1016/j.tree.2012.03.002

Dethlefsen, L., & Relman, D. (2010). Colloquium Paper: Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation Proceedings of the National Academy of Sciences, 108 (Supplement_1), 4554-4561 DOI: 10.1073/pnas.1000087107

Stensvold, C., Christiansen, D., Olsen, K., & Nielsen, H. (2011). Blastocystis sp. Subtype 4 is Common in Danish Blastocystis-Positive Patients Presenting with Acute Diarrhea American Journal of Tropical Medicine and Hygiene, 84 (6), 883-885 DOI: 10.4269/ajtmh.2011.11-0005

Domínguez-Márquez, M., Guna, R., Muñoz, C., Gómez-Muñoz, M., & Borrás, R. (2009). High prevalence of subtype 4 among isolates of Blastocystis hominis from symptomatic patients of a health district of Valencia (Spain) Parasitology Research, 105 (4), 949-955 DOI: 10.1007/s00436-009-1485-y

Stensvold, C., (2012). Thinking Blastocystis Out Of The Box. Trends in Parasitology DOI: 10.1016/

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Genome Med. 2016 Apr 21;8(1):43. (doi: 10.1186/s13073-016-0299-7)

An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis. Chen J1, Wright K2, Davis JM2, Jeraldo P3, Marietta EV4, Murray J4, Nelson H3, Matteson EL2, Taneja V5.

Arthritis Rheumatol. 2016 Jun 23. doi: 10.1002/art.39785. [Epub ahead of print]

Human Gut-Derived Prevotella histicola Suppresses Inflammatory Arthritis in Humanized Mice. Marietta EV, Murray JA, Luckey DH, Jeraldo PR, Lamba A, Patel R, Luthra HS, Mangalam A2, Taneja V.


Marietta EV, Gomez AM, Yeoman C, Tilahun AY, Clark CR, Luckey DH, Murray JA, White BA, Kudva YC, Rajagopalan G. Low incidence of spontaneous type 1 diabetes in non-obese diabetic mice raised on gluten-free diets is associated with changes in the intestinal microbiome. PLoS One. 2013; 8(11):e78687. Epub 2013 Nov 13.

Cospeciation of gut microbiota with hominids

Andrew H. Moeller et al. Science  22 Jul 2016: Vol. 353, Issue 6297, pp. 380-382
doi: 10.1126/science.aaf3951

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour. Anthony J. Filiano et al. Nature 535, 425–429

(21 July 2016) (doi: 10.1038/nature18626).

Investigation of 2 Types of Self-administered Acupressure for Persistent Cancer-Related Fatigue in Breast Cancer Survivors: A Randomized Clinical Trial

Suzanna M. Zick, ND, MPH1,2; Ananda Sen, PhD1,3; Gwen K. Wyatt, PhD, RN4; Susan L. Murphy, PhD5,6; J. Todd Arnedt, PhD7,8,9; Richard E. Harris, PhD10

JAMA Oncol. Published online July 07, 2016.

doi: 10.1001/jamaoncol.2016.1867).

Pietro Ghezzi, Vincent Jaquet, Fabrizio Marcucci, Harald H.H.W. Schmidt. The oxidative stress theory of disease: levels of evidence and epistemological aspects. British Journal of Pharmacology, 2016; DOI: 10.1111/bph.13544

July 2016


Ann Intern Med. 2005 Feb 15;142(4):260-73 (doi: 10.7326/0003-4819-142-4-200502150-00008).
Systematic review: the relationship between clinical experience and quality of health care. Choudhry NK1, Fletcher RH, Soumerai SB.


Evaluation of a functional medicine approach to treating fatigue, stress, and digestive issues in women. Susanne M. Cutshall,
Larry R. Bergstrom, Daniel J. Kalish. Complementary Therapies in Clinical Practice, May 2016, Volume 23, Pages 75–81.
Buffington et al. Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring. Cell, 2016 DOI: 10.1016/j.cell.2016.06.001
Guess, et al. A randomised controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes. Nutrition & Metabolism 2015 Oct; 12: 36.


1. Juby AG, Hanly MG, Lukaczer D. Clinical challenges in thyroid disease: Time for a new approach? Maturitas. 2016 May;87:72-8.
2. Sategna-Guidetti C, et al. Prevalence of thyroid disorders in untreated adult celiac disease patients and effect of gluten withdrawal: an Italian multicenter study. Am J Gastroenterol. 2001 Mar;96(3):751-7.
3. Karbownik-Lewińska M, Kokoszko-Bilska A. Oxidative damage to macromolecules in the thyroid – experimental evidence. Thyroid Res. 2012 Dec 27;5(1):25.
4. Mancini A, et al. Thyroid Hormones, Oxidative Stress, and Inflammation. Mediators Inflamm. 2016;2016:6757154.
5. Chen A, Kim SS, Chung E, Dietrich KN. Thyroid hormones in relation to lead, mercury, and cadmium exposure in the National Health and Nutrition Examination Survey, 2007-2008. Environ Health Perspect. 2013 Feb;121(2):181-6.
6. Fortunato RS, Ferreira AC, Hecht F, Dupuy C, Carvalho DP. Sexual dimorphism and thyroid dysfunction: a matter of oxidative stress? J Endocrinol. 2014 Apr 22;221(2):R31-40.
7. Vita R, Lapa D, Vita G, Trimarchi F, Benvenga S. A patient with stress-related onset and exacerbations of Graves disease. Nat Clin Pract Endocrinol Metab. 2009 Jan;5(1):55-61.
8. The Lancet Diabetes Endocrinology. Iodine deficiency in the UK: grabbing the low-hanging fruit. Lancet Diabetes Endocrinol. 2016 Jun;4(6):469.
9. Zimmermann MB, Boelaert K. Iodine deficiency and thyroid disorders. Lancet Diabetes Endocrinol. 2015 Apr;3(4):286-95.
10. Kahaly G, Dienes HP, Beyer J, Hommel G. Randomized, double blind, placebo-controlled trial of low dose iodide in endemic goiter. J Clin Endocrinol Metab. 1997 Dec;82(12):4049-53.
11. Herter-Aeberli I, et al. Iodine Supplementation Decreases Hypercholesterolemia in Iodine-Deficient, Overweight Women: A Randomized Controlled Trial. J Nutr. 2015 Sep;145(9):2067-75.
12. Farhangi MA, Keshavarz SA, Eshraghian M, Ostadrahimi A, Saboor-Yaraghi AA. The effect of vitamin A supplementation on thyroid function in premenopausal women. J Am Coll Nutr. 2012 Aug;31(4):268-74.
13. Duntas LH, Papanastasiou L, Mantzou E, Koutras DA. Incidence of sideropenia and effects of iron repletion treatment in women with subclinical hypothyroidism. Exp Clin Endocrinol Diabetes. 1999;107(6):356-60.
14. Kandhro GA, Kazi TG, Afridi HI, Kazi N, Baig JA, Arain MB, Sirajuddin, Shah AQ, Sarfraz RA, Jamali MK, Syed N. Effect of zinc supplementation on the zinc level in serum and urine and their relation to thyroid hormone profile in male and female goitrous patients. Clin Nutr. 2009 Apr;28(2):162-8.
15. Toulis KA, Anastasilakis AD, Tzellos TG, Goulis DG, Kouvelas D. Selenium supplementation in the treatment of Hashimoto’s thyroiditis: a systematic review and a meta-analysis. Thyroid. 2010 Oct;20(10):1163-73.
16. Palinkas LA, Reedy KR, Smith M, Anghel M, Steel GD, Reeves D, Shurtleff D, Case HS, Van Do N, Reed HL. Psychoneuroendocrine effects of combined thyroxine and triiodothyronine versus tyrosine during prolonged Antarctic residence. Int J Circumpolar Health. 2007 Dec;66(5):401-17.
17. Felker P, Bunch R, Leung AM. Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism. Nutr Rev. 2016 Apr;74(4):248-58.
18. Sathyapalan T, Manuchehri AM, Thatcher NJ, Rigby AS, Chapman T, Kilpatrick ES, Atkin SL. The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: a randomized, double-blind, crossover study. J Clin Endocrinol Metab. 2011 May;96(5):1442-9.
19. Messina M, Redmond G. Effects of soy protein and soybean isoflavones on thyroid function in healthy adults and hypothyroid patients: a review of the relevant literature. Thyroid. 2006 Mar;16(3):249-58.
20. Peckham S, Lowery D, Spencer S. Are fluoride levels in drinking water associated with hypothyroidism prevalence in England? A large observational study of GP practice data and fluoride levels in drinking water. J Epidemiol Community Health. 2015 Jul;69(7):619-24.
21. Chandra AK, Goswami H, Sengupta P. Dietary calcium induced cytological and biochemical changes in thyroid. Environ Toxicol Pharmacol. 2012 Sep;34(2):454-65.
22. Wang N, Zhou Y, Fu C, Wang H, Huang P, Wang B, Su M, Jiang F, Fang H, Zhao Q, Chen Y, Jiang Q. Influence of Bisphenol A on Thyroid Volume and Structure Independent of Iodine in School Children. PLoS One. 2015 Oct 23;10(10):e0141248.
23. Pelletier C, Doucet E, Imbeault P, Tremblay A. Associations between weight loss-induced changes in plasma organochlorine concentrations, serum T(3) concentration, and resting metabolic rate. Toxicol Sci. 2002 May;67(1):46-51.
24. Di Matola T, Zeppa P, Gasperi M, Vitale M. Thyroid dysfunction following a kelp-containing marketed diet. BMJ Case Rep. 2014 Oct 29;2014.
25. Sategna-Guidetti C, et al. Prevalence of thyroid disorders in untreated adult celiac disease patients and effect of gluten withdrawal: an Italian multicenter study. Am J Gastroenterol. 2001 Mar;96(3):751-7.

PANEL: Antje Brüser, Angela Schulz, Sven Rothemund, Albert Ricken, Davide Calebiro, Gunnar Kleinau, Torsten Schöneberg. The Activation Mechanism of Glycoprotein Hormone Receptors with Implications in the Cause and Therapy of Endocrine Diseases. Journal of Biological Chemistry, 2016; 291 (2): 508 DOI: 10.1074/jbc.M115.701102

Miguel’s key papers and suggestions for further reading

Bhullar, K. S. & Rupasinghe, H. P. (2013) Polyphenols: multipotent therapeutic agents in neurodegenerative diseases. Oxid Med Cell Longev, 2013pp. 891748.

Cascalheira, J. F., Goncalves, M., Barroso, M., Castro, R., Palmeira, M., Serpa, A., Dias-Cabral, A. C., Domingues, F. C. & Almeida, S. (2015) Association of the transcobalamin II gene 776C –> G polymorphism with Alzheimer’s type dementia: dependence on the 5, 10-methylenetetrahydrofolate reductase 1298A –> C polymorphism genotype. Ann Clin Biochem, 52(Pt 4) pp. 448-55.

Fowler, A. K., Hewetson, A., Agrawal, R. G., Dagda, M., Dagda, R., Moaddel, R., Balbo, S., Sanghvi, M., Chen, Y., Hogue, R. J., Bergeson, S. E., Henderson, G. I. & Kruman, Ii (2012) Alcohol-induced one-carbon metabolism impairment promotes dysfunction of DNA base excision repair in adult brain. J Biol Chem, 287(52) pp. 43533-42.

Iriti, M. & Varoni, E. M. (2015) Melatonin in Mediterranean diet, a new perspective. J Sci Food Agric, 95(12) pp. 2355-9.

Lopes Da Silva, S., Vellas, B., Elemans, S., Luchsinger, J., Kamphuis, P., Yaffe, K., Sijben, J., Groenendijk, M. & Stijnen, T. (2014) Plasma nutrient status of patients with Alzheimer’s disease: Systematic review and meta-analysis. Alzheimers Dement, 10(4) pp. 485-502.

Pallauf, K., Giller, K., Huebbe, P. & Rimbach, G. (2013) Nutrition and healthy ageing: calorie restriction or polyphenol-rich “MediterrAsian” diet? Oxid Med Cell Longev, 2013pp. 707421.

Pedret, A., Valls, R. M., Fernandez-Castillejo, S., Catalan, U., Romeu, M., Giralt, M., Lamuela-Raventos, R. M., Medina-Remon, A., Arija, V., Aranda, N., Espinel, A., Delgado, M. A. & Sola, R. (2012) Polyphenol-rich foods exhibit DNA antioxidative properties and protect the glutathione system in healthy subjects. Mol Nutr Food Res, 56(7) pp. 1025-33.

Rai, V. (2016) Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism and Alzheimer Disease Risk: a Meta-Analysis. Mol Neurobiol, pp.

Scoditti, E., Capurso, C., Capurso, A. & Massaro, M. (2014) Vascular effects of the Mediterranean diet-part II: role of omega-3 fatty acids and olive oil polyphenols. Vascul Pharmacol, 63(3) pp. 127-34.
Shen, L. & Ji, H. F. (2015) Associations between Homocysteine, Folic Acid, Vitamin B12 and Alzheimer’s Disease: Insights from Meta-Analyses. J Alzheimers Dis, 46(3) pp. 777-90.

Toledo, E., Salas-Salvado, J., Donat-Vargas, C., Buil-Cosiales, P., Estruch, R., Ros, E., Corella, D., Fito, M., Hu, F. B., Aros, F., Gomez-Gracia, E., Romaguera, D., Ortega-Calvo, M., Serra-Majem, L., Pinto, X., Schroder, H., Basora, J., Sorli, J. V., Bullo, M., Serra-Mir, M. & Martinez-Gonzalez, M. A. (2015) Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial. JAMA Intern Med, 175(11) pp. 1752-60.

Tuttolomondo, A., Casuccio, A., Butta, C., Pecoraro, R., Di Raimondo, D., Della Corte, V., Arnao, V., Clemente, G., Maida, C., Simonetta, I., Miceli, G., Lucifora, B., Cirrincione, A., Di Bona, D., Corpora, F., Maugeri, R., Iacopino, D. G. & Pinto, A. (2015) Mediterranean Diet in patients with acute ischemic stroke: Relationships between Mediterranean Diet score, diagnostic subtype, and stroke severity index. Atherosclerosis, 243(1) pp. 260-7.


Daniel Brugger, Wilhelm M. Windisch. Subclinical zinc deficiency impairs pancreatic digestive enzyme activity and digestive capacity of weaned piglets. British Journal of Nutrition, 2016; 1 (doi: 10.1017/S0007114516002105).

Sci Rep. 2016 Jun 3;6:27010. doi: 10.1038/srep27010.
Paternal under-nutrition programs metabolic syndrome in offspring which can be reversed by antioxidant/vitamin food fortification in fathers.
McPherson NO1,2, Fullston T1, Kang WX1, Sandeman LY1, Corbett MA3, Owens JA1, Lane M1,4.

J Med Food. 2016 May 20. [Epub ahead of print] doi: 10.1089/jmf.2016.0030.
Inhibition of TNF-α, IL-1α, and IL-1β by Pretreatment of Human Monocyte-Derived Macrophages with Menaquinone-7 and Cell Activation with TLR Agonists In Vitro.
Pan MH, Maresz K5, Lee PS4, Wu JC4, Ho CT6, Popko J7,8, Mehta DS9, Stohs SJ10, Badmaev V.

Ramon Estruch, Miguel Angel Martínez-González, Dolores Corella, Jordi Salas-Salvadó, Montserrat Fitó, Gemma Chiva-Blanch, Miquel Fiol, Enrique Gómez-Gracia, Fernando Arós, José Lapetra, Lluis Serra-Majem, Xavier Pintó, Pilar Buil-Cosiales, José V Sorlí, Miguel A Muñoz, Josep Basora-Gallisá, Rosa María Lamuela-Raventós, Mercè Serra-Mir, Emilio Ros. Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial. The Lancet Diabetes & Endocrinology, 2016; DOI: 10.1016/S2213-8587(16)30085-7
Moran Yassour et al. Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability. Science Translational Medicine, 2016 DOI: 10.1126/scitranslmed.aad0917 .
Franziska Faber, Lisa Tran, Mariana X. Byndloss, Christopher A. Lopez, Eric M. Velazquez, Tobias Kerrinnes, Sean-Paul Nuccio, Tamding Wangdi, Oliver Fiehn, Renée M. Tsolis, Andreas J. Bäumler. Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion. Nature, 2016; DOI: 10.1038/nature18597 .
Catherine R. Marinac, Sandahl H. Nelson, Caitlin I. Breen, Sheri J. Hartman, Loki Natarajan, John P. Pierce, Shirley W. Flatt, Dorothy D. Sears, Ruth E. Patterson. Prolonged Nightly Fasting and Breast Cancer Prognosis. JAMA Oncology, 2016; DOI: 10.1001/jamaoncol.2016.0164.
Sara Vieira-Silva, Gwen Falony, Youssef Darzi, Gipsi Lima-Mendez, Roberto Garcia Yunta, Shujiro Okuda, Doris Vandeputte, Mireia Valles-Colomer, Falk Hildebrand, Samuel Chaffron, Jeroen Raes. Species–function relationships shape ecological properties of the human gut microbiome. Nature Microbiology, 2016; 16088 DOI: 10.1038/nmicrobiol.2016.88.
Lakshmi Krishnamoorthy, Joseph A Cotruvo, Jefferson Chan, Harini Kaluarachchi, Abigael Muchenditsi, Venkata S Pendyala, Shang Jia, Allegra T Aron, Cheri M Ackerman, Mark N Vander Wal, Timothy Guan, Lukas P Smaga, Samouil L Farhi, Elizabeth J New, Svetlana Lutsenko, Christopher J Chang. Copper regulates cyclic-AMP-dependent lipolysis. Nature Chemical Biology, 2016; DOI: 10.1038/nchembio.2098
Dale E. Bredesen, Edwin C. Amos3, Jonathan Canick4, Mary Ackerley5, Cyrus Raji6, Milan Fiala7, and Jamila Ahdidan, Aging 2016, 8 (6):