References

IHCAN Feb 2017 references

NEWS

Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis.

Ciccia F, Guggino G, Rizzo A, Alessandro R, Luchetti MM, Milling S, Saieva L, Cypers H, Stampone T, Di Benedetto P, Gabrielli A, Fasano A, Elewaut D, Triolo G.

Ann Rheum Dis. 2017 Jan 9. pii: annrheumdis-2016-210000. doi: 10.1136/annrheumdis-2016-210000. [Epub ahead of print]

Ahmed Tawakol, Amorina Ishai, Richard AP Takx, Amparo L Figueroa, Abdelrahman Ali, Yannick Kaiser, Quynh A Truong, Chloe JE Solomon, Claudia Calcagno, Venkatesh Mani, Cheuk Y Tang, Willem JM Mulder, James W Murrough, Udo Hoffmann, Matthias Nahrendorf, Lisa M Shin, Zahi A Fayad, Roger K Pitman. Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study. The Lancet, 2017; DOI: 10.1016/S0140-6736(16)31714-7

J Calvin Coffey, D Peter O’Leary. The mesentery: structure, function, and role in disease. The Lancet Gastroenterology & Hepatology, 2016; 1 (3): 238 DOI: 10.1016/S2468-1253(16)30026-7

Heather F. Smith, William Parker, Sanet H. Kotzé, Michel Laurin. Morphological evolution of the mammalian cecum and cecal appendix. Comptes Rendus Palevol, 2017; 16 (1): 39 DOI: 10.1016/j.crpv.2016.06.001

LYME – JONATHAN OPRCHARD
Eur Spine J. 2013 Apr;22(4):697-707. doi: 10.1007/s00586-013-2675-y. Epub 2013 Feb 13. Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy.

Albert HB1, Sorensen JS, Christensen BS, Manniche C.

Br J Sports Med. 2008 Dec;42(12):969-73. doi: 10.1136/bjsm.2008.050369. Epub 2008 Aug 21. Antibiotic treatment in patients with low-back pain associated with Modic changes Type 1 (bone oedema): a pilot study.

Albert HB1, Manniche C, Sorensen JS, Deleuran BW.

Eur J Microbiol Immunol (Bp). 2015 Dec; 5(4): 268–280.

Published online 2015 Nov 12. doi:  10.1556/1886.2015.00031

Effectiveness of Stevia Rebaudiana Whole Leaf Extract Against the Various Morphological Forms of Borrelia Burgdorferi in Vitro

1. A. S. Theophilus, M. J. Victoria, K. M. Socarras, K. R. Filush, K. Gupta, D. F. Luecke, and E. Sapi

OSTEOARTHRITIS – BEN BROWN

1. Glyn-Jones S, et al Osteoarthritis. 2015 Mar 3. pii: S0140-6736(14)60802-3.
2. Patrono C, Baigent C. Nonsteroidal anti-inflammatory drugs and the heart. Circulation. 2014 Feb 25;129(8):907-16.
3. Green JA, Hirst-Jones KL, Davidson RK, et al. The potential for dietary factors to prevent or treat osteoarthritis. Proc Nutr Soc. 2014 May;73(2):278-88.
4. Veronese N, Stubbs B, Noale M, Solmi M, Luchini C, Maggi S. Adherence to the Mediterranean diet is associated with better quality of life: data from the Osteoarthritis Initiative. Am J Clin Nutr. 2016 Nov;104(5):1403-1409.
5. Clinton CM, et al. Whole-foods, plant-based diet alleviates the symptoms of osteoarthritis. Arthritis. 2015;2015:708152.
6. Gudbergsen H, et al. Weight loss is effective for symptomatic relief in obese subjects with knee osteoarthritis independently of joint damage severity assessed by high-field MRI and radiography. Osteoarthritis Cartilage. 2012 Jun;20(6):495-502.
7. Riecke BF, et al. Comparing two low-energy diets for the treatment of knee osteoarthritis symptoms in obese patients: a pragmatic randomized clinical trial. Osteoarthritis Cartilage. 2010 Jun;18(6):746-54.
8. DeChristopher LR, Uribarri J, Tucker KL. Intake of high-fructose corn syrup sweetened soft drinks, fruit drinks and apple juice is associated with prevalent arthritis in US adults, aged 20-30 years. Nutr Diabetes. 2016 Mar 7;6:e199.
9. Ghoochani N, Karandish M, Mowla K, Haghighizadeh MH, Jalali MT. The effect of pomegranate juice on clinical signs, matrix metalloproteinases and antioxidant status in patients with knee osteoarthritis. J Sci Food Agric. 2016 Oct;96(13):4377-81.
10. Schumacher HR, Pullman-Mooar S, Gupta SR, Dinnella JE, Kim R, McHugh MP. Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee. Osteoarthritis Cartilage. 2013 Aug;21(8):1035-41.
11. Hashempur MH, Sadrneshin S, Mosavat SH, Ashraf A. Green tea (Camellia sinensis) for patients with knee osteoarthritis: A randomized open-label active-controlled clinical trial. Clin Nutr. 2016 Dec 18.
12. Rovati LC, Girolami F, Persiani S. Crystalline glucosamine sulphate in the management of knee osteoarthritis: efficacy, safety, and pharmacokinetic properties. Ther Adv Musculoskelet Dis. 2012 Jun;4(3):167-80.
13. Reginster JY, et al. Role of glucosamine in the treatment for osteoarthritis. Rheumatol Int. 2012 Oct;32(10):2959-67.
14. Salazar J, et al. Glucosamine for osteoarthritis: biological effects, clinical efficacy, and safety on glucose metabolism. Arthritis. 2014;2014:432463
15. Biggee BA, Blinn CM, McAlindon TE, et al. Low levels of human serum glucosamine after ingestion of glucosamine sulphate relative to capability for peripheral effectiveness. Ann Rheum Dis. 2006 Feb;65(2):222-6.
16. Coulson S, Butt H, Vecchio P, et al. Green-lipped mussel extract (Perna canaliculus) and glucosamine sulphate in patients with knee osteoarthritis: therapeutic efficacy and effects on gastrointestinal microbiota profiles. 2013 Feb;21(1):79-90.
17. Henrotin Y, Marty M, Mobasheri A. What is the current status of chondroitin sulphate and glucosamine for the treatment of knee osteoarthritis? Maturitas. 2014 Jul;78(3):184-7.
18. Singh JA, Noorbaloochi S, MacDonald R, Maxwell LJ. Chondroitin for osteoarthritis. Cochrane Database Syst Rev. 2015 Jan 28;1:CD005614.
19. Zeng C, Wei J, Li H, Wang YL, Xie DX, Yang T, Gao SG, Li YS, Luo W, Lei GH. Effectiveness and safety of Glucosamine, chondroitin, the two in combination, or celecoxib in the treatment of osteoarthritis of the knee. Sci Rep. 2015 Nov 18;5:16827.
20. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulphate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006 Feb 23;354(8):795-808.
21. Usha PR, Naidu MU. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis. Clin Drug Investig. 2004;24(6):353-63.
22. Debbi EM, et al. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011 Jun 27;11:50.
23. Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical Osteoarthritis Cartilage. 2006 Mar;14(3):286-94.
24. Bagchi D, et al. Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. Int J Clin Pharmacol Res. 2002;22(3-4):101-10.
25. Crowley DC, et al. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci. 2009 Oct 9;6(6):312-21
26. Abdel-Tawab M, et al. Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data. Clin Pharmacokinet. 2011 Jun;50(6):349-69. Doi
27. Cameron M, Chrubasik S. Oral herbal therapies for treating osteoarthritis. Cochrane Database Syst Rev. 2014 May 22;5:CD002947.
28. Vishal AA, Mishra A, Raychaudhuri SP. A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee. Int J Med Sci. 2011;8(7):615-22.
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MEDICAL NLP

1. Pinker S (New Ed 1995) The Language Instinct: The New Science of Language and Mind. London: Penguin Books Ltd

² House JS, Landis KR, Umberson D (1988) Social relations and health.  Science  241:  540–5; Hafen Q, Karren KJ, Frandsen KJ, Smith NL (1996)  Mind/Body Health: The Effects of Attitudes, Emotions and Relationships , Boston: Allyn & Bacon; The GUSTO Investigators (1993) An international randomized trial comparing four thrombolytic studies for acute myocardial infarction.  New England Journal of Medicine 329: 673–82.

³ Witthöft M, Rubin GJ (2013), Are media warnings about the adverse health effects of modern life self-fulfilling? An experimental study on idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF) Journal of Psychosomatic Research

⁴ Osmo A. Wiio (1978). Wiion lait – ja vähän muidenkin (Wiio’s laws – and some others). Weilin+Göös.

⁵ Sigmund Freud  The Standard Edition of the Complete Psychological Works of Sigmund Freud, translated and edited by James Strachey.  The Institute of Psycho-Analysis and The Hogarth Press

⁶ Freud S (Paperback ed. 1991) Introductory Lectures (1916-17). London:Penguin Books Ltd

⁷ Rosencranz MA et al (2005) Neural circuitry underlying the interaction between emotion and asthma symptom exacerbation. PNAS 102 (37): 13319–24.

⁸ Langer E, Dillon M, Kurtz R, and Katz M (1998) Believing is Seeing, Harvard University, Department of Psychology.

⁹ Coversation with author

¹⁰ Olde Hartman TC, Lucassen PL, van de Lisdonk EH et al (2004) Chronic functional somatic symptoms: a single syndrome? British Journal of General Practice 54: 922–7.
¹¹ See Dr Bandler’s introduction to the 1^st edition of Magic in Practice

BLOATING – PATRICK HOLFORD

1. Holford & Associates Ltd. 100% Digestive Health Survey, awaiting publication in February.
2. Zar, S., et al. Food-specific serum IgG4 and IgE titers to common food antigens in irritable bowel syndrome. Am J Gastroenterol.. 2005 Jul; 100(7):1550–7; see also Zuo X.L., et al. Alterations of food antigen-specific serum immunoglobulins G and E antibodies in patients with irritable bowel syndrome and functional dyspepsia. Clin Exp Allergy. 2007 Jun; 37(6):823-30.
3. Finn R., et al. Immunological hypersensitivity to environmental antigens in the irritable bowel syndrome. Br J Clin Pract. 1987 Dec; 41(12):1041-3.
4. Zar, S., et al. Food-specific serum IgG4 and IgE titers to common food antigens in irritable bowel syndrome. Am J Gastroenterol.. 2005 Jul; 100(7):1550–7.
5. Atkinson, W., et al. Food elimination based on IgG antibodies in irritable bowel syndrome: A randomised controlled trial. Gut. 2004 Oct; 53(10):1459–64
6. van Gils, T., et al. Prevalence and characterization of self-reported gluten

sensitivity in the Netherlands. Nutrients. 2016 Nov; 8(11):714.

7. Zanwar, V.G., et al. Symptomatic improvement with gluten restriction in irritable bowel syndrome: a prospective, randomized, double blinded placebo controlled

trial. Intestinal Research. 2016 Oct; 14(4):343–350.

8. Sofi, F., et al. Effect of Triticum turgidum subsp. turanicum wheat on irritable bowel syndrome: a double-blinded randomised dietary intervention trial. Br J Nutr. 2014 Jun; 111(1):1992–9.
9. Maagaard L., et al. Follow- up of patients with functional bowel

symptoms treated with a low FODMAP diet. World J Gastroenterol. 2016

Apr; 22(15):4009–19.

10. Eswaran, S.L., et al. A randomised controlled trial comparing the low FODMAP diet vs. modified NICE guidelines in US adults with IBS-D. Am J Gastroenterol. 2016 Dec; 111(12):1824-1832.
11. Iranio, G. Digestive enzyme supplementation in gastrointestinal diseases. Curr Drug Metab. 2016 Feb; 17(2):187–193.
12. Moayyedi, P., et al. The efficacy of probiotics in the treatment of

irritable bowel syndrome: A systematic review. Gut. 2010 Mar; 59(3):325–32.

13. Silk, D.B., et al. Clinical trial: The effects of a transgalactooligosaccharide

prebiotic on faecal microbiota and symptoms in irritable bowel syndrome. Aliment Pharmacology and Therapeutics. 2009 Mar; 29(5):508–18.

14. Jalanka- Tuovinen, J., et al. Intestinal microbiota in healthy adults:

Temporal analysis reveals individual and common core and relation to intestinal symptoms. PLoS One, 2011 Jul; 6(7):e23035.

15. 1 Baştür, A., et al. Efficacy of synbiotic, probiotic, and prebiotic treatments for

irritable bowel syndrome in children: A randomized controlled

trial. Turk J Gastroenterol. 2016 Sep; 27(5):439-443.

LEARNING ZONE – LYME

1. PHE/RIPL website: https://www.gov.uk/government/collections/rare-and-imported-pathogens-laboratory-ripl
   2. Stevenson B. Variable VlsE Is Critical for Host Reinfection by the Lyme Disease Spirochete. PLoS One. 2013, 8(4)
   3. Meriläinen L et al. Morphological and biochemical features of Borrelia burgdorferi pleomorphic forms. Microbiology. 2015 Mar;161(Pt 3):516-27.
   4. Sapi E et al. Characterization of Biofilm Formation by Borrelia burgdorferi In Vitro. PLoS One. 2013 7(10)
   5. Cook MJ and Puri BP. Commercial test kits for detection of Lyme borreliosis: a meta-analysis of test accuracy. Int J Gen Med. 2016, Nov 18;9:427-440
   6. Stricker RB et al. Lyme disease: the promise of Big Data, companion diagnostics and precision medicine. Infect Drug Resist. 2016;9:215-219
   7. Lehman PV et al. Unique Strengths of ELISPOT for T Cell Diagnostics. In: Kalyuzhny AE. Handbook of ELISPOT: Methods and Protocols, Methods in Molecular Biology, Vol. 792. 2nd Ed: Springer; 2012: 3-23.
   8. Stricker RB and Winger EE. Decreased CD57 Lymphocyte Subset in Patients with Chronic Lyme Disease. Immunology Letters, 2001;76, 43-48.

LEARNING ZONE – the Sensitivity Gene

* The January 2015 Duke University study, “Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial,” was published in the Journal of Policy Analysis and Management.
*Benedicte Meyer et al, Maintenance of Chronic Fatigue Syndrome (CFS) in Young CFS Patients Is Associated with the 5-HTTLPR and SNP rs25531 A > G Genotype. PLOS One,  2015, http://dx.doi.org/10.1371/journal.pone.0140883

* Felitti VJ, Anda RF et al. Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults: The Adverse Childhood Experiences (ACE) Study. Am J Preventive Med May 1998, 14, 4,: 245–58.

* For The Sensitivity Hypothesis, Dandelion and Orchid Children, see research by Bruce Ellis  University of Arizona, and W Thomas Boyce  University of British Columbia, for example “Biological sensitivity to context: I. An evolutionary–developmental theory of the origins and functions of stress reactivity” in Development and Psychopathology

17, 2005, 271–301. DOI: 10.1017/S095457940505014.

* Childhood Disrupted: How Your Biography Becomes Your Biology and How You Can Heal, by Donna Jackson Nakazawa: http://donnajacksonnakazawa.com/childhood-disrupted/.

* GSC – Genetically Sensitive Client- Chrysalis Effect Specialist Practitioner Training Elaine Wilkins: http://www.thechrysaliseffectpractitioners.com/.

RESEARCH

Isabel Garcia-Perez, Joram M Posma, Rachel Gibson, Edward S Chambers, Tue H Hansen, Henrik Vestergaard, Torben Hansen, Manfred Beckmann, Oluf Pedersen, Paul Elliott, Jeremiah Stamler, Jeremy K Nicholson, John Draper, John C Mathers, Elaine Holmes, Gary Frost. Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial. The Lancet Diabetes & Endocrinology, 2017; DOI: 10.1016/S2213-8587(16)30419-3

A Meta-Analysis of Randomized Controlled Trials and Prospective Cohort Studies of Eicosapentaenoic and Docosahexaenoic Long-Chain Omega-3 Fatty Acids and Coronary Heart Disease Risk. Dominik D. Alexander et al. Open Access . DOI: http://dx.doi.org/10.1016/j.mayocp.2016.10.018

Mayo Clinic Proceedings, January 2017, Volume 92, Issue 1, Pages 15–29.

NEWS
Arch Intern Med. 1999 Sep 27;159(17):1981-7.). Homeopathy re-revisited: is homeopathy compatible with biomedical observations? Eskinazi D.

Saha, SK. et al. Ultra–highly diluted plant extracts of Hydrastis canadensis and Marsdenia condurango induce epigenetic modifications and alter gene expression profiles in HeLa cells in vitro.  J. Integr. Med. 13, 400–411 (2015).

Randomised placebo-controlled trials of individualised homeopathic treatment: systematic review and meta-analysis. Robert T Mathie et al. Systematic Rev, 2014, 3:142. DOI: 10.1186/2046-4053-3-142.

Cell, Ocampo et al.: “In vivo amelioration of age-associated hallmarks by partial reprogramming.” DOI: 10.1016/j.cell.2016.11.052 , www.cell.com/cell/fulltext/S0092-8674(16)31664-6

NEW RELEASES

Diabetes Res Clin Pract. 2009 Feb;83(2):e40-2. doi: 10.1016/j.diabres.2008.11.014. Epub 2008 Dec 23. Immediate and long-term effects of glucomannan on total ghrelin and leptin in type 2 diabetes mellitus. Chearskul S1, Kriengsinyos W, Kooptiwut S, Sangurai S, Onreabroi S, Churintaraphan M, Semprasert N, Nitiyanant W.

BEN BROWN

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Additional story:
Antonio Gonzalez, Embriette Hyde, Naseer Sangwan, Jack A. Gilbert, Erik Viirre, Rob Knight. Migraines Are Correlated with Higher Levels of Nitrate-, Nitrite-, and Nitric Oxide-Reducing Oral Microbes in the American Gut Project Cohort. mSystems, October 2016 DOI: 10.1128/mSystems.00105-16
NUTRIGENETICS

Nutritional approaches to combat oxidative stress in Alzheimer’s disease. Butterfield D, Castegna A, Pocernich C, Drake J, Scapagnini G, Calabrese V. J Nutr Biochem. 2002 Aug;13(8):444.

Influence of apple polyphenols on inflammatory gene expression. Jung M, Triebel S, Anke T, Richling E, Erkel G. Mol Nutr Food Res. 2009 Oct;53(10):1263-80. doi: 10.1002/mnfr.200800575.

Christopher T. Ford, Siân Richardson, Francis McArdle, Silvina B. Lotito, Alan Crozier, Anne McArdle, Malcolm J. Jackson. Identification of (poly)phenol treatments that modulate the release of pro-inflammatory cytokines by human lymphocytes. British Journal of Nutrition, 2016; 115 (10): 1699 DOI: 10.1017/S0007114516000805

10. Zamora-Ros, M. Rabassa, A. Cherubini, M. Urpi-Sarda, S. Bandinelli, L. Ferrucci, C. Andres-Lacueva. High Concentrations of a Urinary Biomarker of Polyphenol Intake Are Associated with Decreased Mortality in Older Adults. Journal of Nutrition, 2013; 143 (9): 1445 DOI: 10.3945/jn.113.177121

Harri Hemil. Vitamin E and the risk of pneumonia: using the I²-statistic to quantify heterogeneity within a controlled trial. British Journal of Nutrition, 2016; 1 DOI: 10.1017/S0007114516003408.

Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 – Fields of Precision Nutrition

J Nutrigenet Nutrigenomics 2016;9:12-27, (DOI:10.1159/000445350)

Fulltext PDF (674 Kb) Free Access at www.karger.com/Article/FullText/445350

GUT

From Sample to Multi-Omics Conclusions in under 48 Hours. Robert A. Quinn, Jose A. Navas-Molina, Embriette R. Hyde, Se Jin Song, Yoshiki Vázquez-Baeza, Greg Humphrey, James Gaffney, Jeremiah J. Minich, Alexey V. Melnik, Jakob Herschend, Jeff DeReus, Austin Durant, Rachel J. Dutton, Mahdieh Khosroheidari, Clifford Green, Ricardo da Silva, Pieter C. Dorrestein, Rob Knight

Jack A. Gilbert, Editor. mSystems, 2016: DOI: 10.1128/mSystems.00038-16.

Timothy R. Sampson et al. Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease. Cell, December 2016 DOI: 10.1016/j.cell.2016.11.018.

Christoph A. Thaiss et al. Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations. Cell, December 2016 DOI: 10.1016/j.cell.2016.11.003

Diet-Microbiome Interactions in Health Are Controlled by Intestinal Nitrogen Source Constraints. Andrew J. Holmes et al. Cell Metabolism. In Press. available online 23 November 2016.

RESEARCH
Francesco Foroni, Giulio Pergola, Raffaella Ida Rumiati. Food colour is in the eye of the beholder: the role of human trichromatic vision in food evaluation. Scientific Reports, 2016; 6: 37034 DOI: 10.1038/srep37034

Dagfinn Aune, NaNa Keum, Edward Giovannucci, Lars T. Fadnes, Paolo Boffetta, Darren C. Greenwood, Serena Tonstad, Lars J. Vatten, Elio Riboli, Teresa Norat. Nut consumption and risk of cardiovascular disease, total cancer, all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective studies. BMC Medicine, 2016; 14 (1) DOI: 10.1186/s12916-016-0730-3

10. Zelano, H. Jiang, G. Zhou, N. Arora, S. Schuele, J. Rosenow, J. A. Gottfried. Nasal Respiration Entrains Human Limbic Oscillations and Modulates Cognitive Function. Journal of Neuroscience, 2016; 36 (49): 12448 DOI: 10.1523/JNEUROSCI.2586-16.2016

* Video: https://www.youtube.com/watch?v=1KNn0NYjMWg.

Candyce H. Kroenke, Yvonne L. Michael, Elizabeth M. Poole, Marilyn L. Kwan, Sarah Nechuta, Eric Leas, Bette J. Caan, John Pierce, Xiao-Ou Shu, Ying Zheng, Wendy Y. Chen. Postdiagnosis social networks and breast cancer mortality in the After Breast Cancer Pooling Project. Cancer, 2016; DOI: 10.1002/cncr.30440.

10. Gunness, J. Michiels, L. Vanhaecke, S. De Smet, O. Kravchuk, A. Van de Meene, M. J. Gidley. Reduction in circulating bile acid and restricted diffusion across the intestinal epithelium are associated with a decrease in blood cholesterol in the presence of oat  -glucan. The FASEB Journal, 2016; 30 (12): 4227 DOI: 10.1096/fj.201600465R.

Inmaculada Moreno, Francisco M. Codoñer, Felipe Vilella, Diana Valbuena, Juan F. Martinez-Blanch, Jorge Jimenez-Almazán, Roberto Alonso, Pilar Alamá, Jose Remohí, Antonio Pellicer, Daniel Ramon, Carlos Simon. Evidence that the endometrial microbiota has an effect on implantation success or failure. American Journal of Obstetrics and Gynecology, 2016; 215 (6): 684 DOI: 10.1016/j.ajog.2016.09.075

Haiqiu Huang, Xiaojing Jiang, Zhenlei Xiao, Lu Yu, Quynhchi Pham, Jianghao Sun, Pei Chen, Wallace Yokoyama, Liangli Lucy Yu, Yaguang Sunny Luo, Thomas T. Y. Wang. Red Cabbage Microgreens Lower Circulating Low-Density Lipoprotein (LDL), Liver Cholesterol, and Inflammatory Cytokines in Mice Fed a High-Fat Diet. Journal of Agricultural and Food Chemistry, 2016; 64 (48): 9161 DOI: 10.1021/acs.jafc.6b03805

NEWS

Giannis Koukkidis, Richard Haigh, Natalie Allcock, Suzanne Jordan, and Primrose Freestone. Salad leaf juices enhance Salmonella growth, fresh produce colonisation and virulence. Applied and Environmental Microbiology, November 2016 DOI: 10.1128/AEM.02416-16
Cheng-Shiuan Lee, Molly E. Lutcavage, Emily Chandler, Daniel J. Madigan, Robert M. Cerrato, Nicholas S. Fisher. Declining Mercury Concentrations in Bluefin Tuna Reflect Reduced Emissions to the North Atlantic Ocean. Environmental Science & Technology, 2016; DOI: 10.1021/acs.est.6b04328

Lei Yin, Kevin Yu, Simon Lin, Xiao Song, Xiaozhong Yu. Associations of blood mercury, inorganic mercury, methyl mercury and bisphenol A with dental surface restorations in the U.S. population, NHANES 2003–2004 and 2010–2012. Ecotoxicology and Environmental Safety, 2016; 134: 213 DOI: 10.1016/j.ecoenv.2016.09.001

Dr Mark Hyman on mercury:
http://drhyman.com/blog/2010/05/20/mercury-get-this-poison-out-of-your-body.

NEWS EXTRA

Elmira Akbari, Zatollah Asemi, Reza Daneshvar Kakhaki, Fereshteh Bahmani, Ebrahim Kouchaki, Omid Reza Tamtaji, Gholam Ali Hamidi, Mahmoud Salami. Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer’s Disease: A Randomized, Double-Blind and Controlled Trial. Frontiers in Aging Neuroscience, 2016; 8 DOI: 10.3389/fnagi.2016.00256

BEN BROWN Migraine

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3. Lipton RB, Bigal ME, Diamond M, Freitag F, Reed ML, Stewart WF; AMPP Advisory  Group.. Migraine prevalence, disease burden, and the need for preventive therapy. Neurology. 2007 Jan 30;68(5):343-9.4. Bigal M, Krymchantowski AV, Lipton RB. Barriers to satisfactory migraine outcomes. What have we learned, where do we stand? Headache. 2009 Jul;49(7):1028-41.5. Sun-Edelstein C, Rapoport AM. Update on the Pharmacological Treatment of Chronic Migraine. Curr Pain Headache Rep. 2016 Jan;20(1):6.6. Peck KR, Johnson YL, Smitherman TA. Migraine. Handb Clin Neurol. 2016;138:283-93. 7. Carod-Artal FJ. Tackling chronic migraine: current perspectives. J Pain Res. 2014 Apr 8;7:185-94.8. May A, Schulte LH. Chronic migraine: risk factors, mechanisms and treatment. Nat Rev Neurol. 2016 Aug;12(8):455-64.9. Buture A, Gooriah R, Nimeri R, Ahmed F. Current Understanding on Pain Mechanism in Migraine and Cluster Headache. Anesth Pain Med. 2016 Apr10.                           23;6(3):e35190.11.                           Dalkara T, Zervas NT, Moskowitz MA. From spreading depression to the trigeminovascular system. Neurol Sci. 2006 May;27 Suppl 2:S86-90.12.                           Sheeler RD, Garza I, Vargas BB, O’Neil AE. Chronic Daily Headache: Ten Steps for Primary Care Providers to Regain Control. Headache. 2016 Aug 23. doi: 10.1111/head.12881. [Epub ahead of print]

13. Sun-Edelstein C, Mauskop A. Alternative headache treatments: nutraceuticals, behavioral and physical treatments. Headache. 2011;51:469–83

14.                           Sun-Edelstein C, Mauskop A. Foods and supplements in the management of migraine headaches. Clin J Pain. 2009 Jun;25(5):446-52. 15.                           Cámara-Lemarroy CR, Rodriguez-Gutierrez R, Monreal-Robles R, Marfil-Rivera A.  Gastrointestinal disorders associated with migraine: A comprehensive review. World J Gastroenterol. 2016 Sep 28;22(36):8149-60.

16. Gasbarrini A, Gabrielli M, Fiore G, Candelli M, Bartolozzi F, De Luca A, Cremonini F, Franceschi F, Di Campli C, Armuzzi A, et al. Association between Helicobacter pylori cytotoxic type I CagA-positive strains and migraine with aura. 2000;20:561–565.
17. Tunca A, Türkay C, Tekin O, Kargili A, Erbayrak M. Is Helicobacter pylori infection a risk factor for migraine? A case-control study.Acta Neurol Belg. 2004;104:161–164.
18. Faraji F, Zarinfar N, Zanjani AT, Morteza A. The effect of Helicobacter pylori eradication on migraine: a randomized, double blind, controlled trial.Pain Physician. 2012;15:495–498
19. Aydinlar EI, Dikmen PY, Tiftikci A, Saruc M, Aksu M, Gunsoy HG, Tozun N. IgG-based elimination diet in migraine plus irritable bowel syndrome. 2013;53:514–525
20. Gabrielli M, Cremonini F, Fiore G, Addolorato G, Padalino C, Candelli M, De Leo ME, Santarelli L, Giacovazzo M, Gasbarrini A, et al. Association between migraine and Celiac disease: results from a preliminary case-control and therapeutic study.Am J Gastroenterol. 2003;98:625–629

21.                           Sensenig J, Johnson M, Staverosky T. Treatment of migraine with targeted nutrition focused on improved assimilation and elimination. Altern Med Rev. 2001  Oct;6(5):488-94.

22. Gonzalez A, Hyde E, Sangwan N, Gilbert JA, Viirre E, Knight R. 2016.Migraines are correlated with higher levels of nitrate-, nitrite-, and nitric oxide-reducing oral microbes in the American Gut Project Cohort. mSystems 1(5):e00105-16.

23.                           de Roos NM, Giezenaar CG, Rovers JM, Witteman BJ, Smits MG, van Hemert S. The  effects of the multispecies probiotic mixture Ecologic®Barrier on migraine: results of an open-label pilot study. Benef Microbes. 2015;6(5):641-6.24.                           Malhotra R. Understanding migraine: Potential role of neurogenic inflammation. Ann Indian Acad Neurol. 2016 Apr-Jun;19(2):175-82.25.                           Lippi G, Mattiuzzi C, Cervellin G. C-reactive protein and migraine. Facts or speculations? Clin Chem Lab Med. 2014 Sep;52(9):1265-72.

26. Theodoropoulos DS, Katzenberger DR, Jones WM, Morris DL, Her C, Cullen NA, et al. Allergen-specific sublingual immunotherapy in the treatment of migraines: a prospective study. Eur Rev Med Pharmacol Sci 2011;15:1117–21
27. Meng WG, Shi L, Wu LY, Lai LY, Song RX, Huang SZ. Clinical research on treatment of migraine with pine needle moxibustion. Zhongguo Zhen Jiu 2012;32:519–22.

28.                           Maghbooli M, Golipour F, Moghimi Esfandabadi A, Yousefi M. Comparison between  the efficacy of ginger and sumatriptan in the ablative treatment of the common migraine. Phytother Res. 2014 Mar;28(3):412-5

29. Liberopoulos EN, Mikhailidis DP. Could statins be useful in the treatment of patients with migraine? Headache 2006;46:672–5
30. Medeiros FL, Medeiros PL, Valença MM, Dodick D. Simvastatin for migraine prevention. Headache 2007;47:855–6.

31.                           Marmura MJ, Silberstein SD, Schwedt TJ. The acute treatment of migraine in adults: the american headache society evidence assessment of migraine pharmacotherapies. Headache. 2015 Jan;55(1):3-20.

32. Bond DS, Roth J, Nash JM, Wing RR. Migraine and obesity: epidemiology, possible mechanisms and the potential role of weight loss treatment.Obes Rev. 2011;12:e362–71.
33. Verrotti A, Agostinelli S, D’Egidio C, Di Fonzo A, Carotenuto M, Parisi P, Esposito M, Tozzi E, Belcastro V, Mohn A, Battistella PA. Impact of a weight loss program on migraine in obese adolescents. Eur J Neurol. 2013 Feb;20(2):394-7

34.                           Yorns WR Jr, Hardison HH. Mitochondrial dysfunction in migraine. Semin Pediatr Neurol. 2013 Sep;20(3):188-93.35.                           Di Lorenzo C, Pierelli F, Coppola G, Grieco GS, Rengo C, Ciccolella M, Magis D, Bolla M, Casali C, Santorelli FM, Schoenen J. Mitochondrial DNA haplogroups influence the therapeutic response to riboflavin in migraineurs. Neurology. 2009  May 5;72(18):1588-94.36.                           Cordero MD, Cano-García FJ, Alcocer-Gómez E, De Miguel M, Sánchez-Alcázar JA. Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q₁₀  effect on clinical improvement. PLoS One. 2012;7(4):e35677. 37.                           Borkum JM. Migraine Triggers and Oxidative Stress: A Narrative Review and Synthesis. Headache. 2016 Jan;56(1):12-35. 38.                           Neri M, Frustaci A, Milic M, Valdiglesias V, Fini M, Bonassi S, Barbanti P. A  meta-analysis of biomarkers related to oxidative stress and nitric oxide pathway  in migraine. Cephalalgia. 2015 Sep;35(10):931-7.39.                           Ciancarelli I, Tozzi-Ciancarelli MG, Spacca G, Di Massimo C, Carolei A. Relationship between biofeedback and oxidative stress in patients with chronic migraine. Cephalalgia. 2007 Oct;27(10):1136-41.40.                           Gonullu H, Gonullu E, Karadas S, Arslan M, Kalemci O, Aycan A, Sayin R, Demir  H. The levels of trace elements and heavy metals in patients with acute migraine  headache. J Pak Med Assoc. 2015 Jul;65(7):694-7.41.                           Chen CC, Tsai SS, Yang CY. Association between Fine Particulate Air Pollution  and Daily Clinic Visits for Migraine in a Subtropical City: Taipei, Taiwan. Int J Environ Res Public Health. 2015 Apr 29;12(5):4697-708.42.                           Szyszkowicz M, Rowe BH, Kaplan GG. Ambient sulphur dioxide exposure and emergency department visits for migraine in Vancouver, Canada. Int J Occup Med Environ Health. 2009;22(1):7-12.43.                           Miller CS. The compelling anomaly of chemical intolerance. Ann N Y Acad Sci. 2001 Mar;933:1-23.44.                           Katerndahl DA, Bell IR, Palmer RF, Miller CS. Chemical intolerance in primary  care settings: prevalence, comorbidity, and outcomes. Ann Fam Med. 2012 Jul-Aug;10(4):357-65. 45.                           Genuis SJ. Toxic causes of mental illness are overlooked. Neurotoxicology. 2008 Nov;29(6):1147-9.

ADAPTOGENS/STRESS

1. Head KA, Kelly GS. Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep. Altern Med Rev. 2009;14(2):114-40.
2. Nielsen NR, Kristensen TS, Schnohr P, et al. Perceived stress and cause-specific mortality among men and women: results from a prospective cohort study. Am J Epidemiol. 2008;168(5):481-91; discussion 92-6.
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21. Raghav S, Singh H, Dalal PK, et al. Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment. Indian J Psychiatry. 2006;48(4):238-42.
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23. Chowdhuri DK, Parmar D, Kakkar P, et al. Antistress effects of bacosides of Bacopa monnieri: modulation of Hsp70 expression, superoxide dismutase and cytochrome P450 activity in rat brain. Phytother Res. 2002;16(7):639-45.
24. Benson S, Downey LA, Stough C, et al. An acute, double-blind, placebo-controlled cross-over study of 320 mg and 640 mg doses of Bacopa monnieri (CDRI 08) on multitasking stress reactivity and mood. Phytother Res. 2014;28(4):551-9.
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27. Ng TB, Wang HX. Pharmacological actions of cordyceps, a prized folk medicine. J Pharm Pharmacol. 2005;57(12):1509-19.
28. Liu JY, Feng CP, Li X, et al. Immunomodulatory and antioxidative activity of cordyceps militaris polysaccharides in mice. Int J Biol Macromol. 2016;86:594-8.
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37. Bhattacharyya D, Sur TK, Jana U, et al. Controlled programmed trial of Ocimum sanctum leaf on generalized anxiety disorders. Nepal Med Coll J. 2008;10(3):176-9.
38. Sampath S, Mahapatra SC, Padhi MM, et al. Holy basil (Ocimum sanctum Linn.) leaf extract enhances specific cognitive parameters in healthy adult volunteers: A placebo controlled study. Indian J Physiol Pharmacol. 2015;59(1):69-77.
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EXTRAS

E. F. G. Naninck, J. E. Oosterink, K.-Y. Yam, L. P. de Vries, H. Schierbeek, J. B. van Goudoever, R.-N. Verkaik-Schakel, J. A. Plantinga, T. Plosch, P. J. Lucassen, A. Korosi. Early micronutrient supplementation protects against early stress-induced cognitive impairments. The FASEB Journal, 2016; DOI: 10.1096/fj.201600834R

Sarkar et al. Psychobiotics and the Manipulation of Bacteria-Brain Signals. Trends in Neurosciences, October 2016 DOI: 10.1016/j.tins.2016.09.002

RESEARCH

PLoS One. 2016 Oct 31;11(10):e0165378. doi: 10.1371/journal.pone.0165378. eCollection 2016. Third Exposure to a Reduced Carbohydrate Meal Lowers Evening Postprandial Insulin and GIP Responses and HOMA-IR Estimate of Insulin Resistance. Lin PJ¹, Borer KT¹.

Giles Major et al. Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-related Symptoms in Individuals with Irritable Bowel Syndrome, Gastroenterology (2016). DOI: 10.1053/j.gastro.2016.09.062

10. Pegorie, D.W. Denning, W. Welfare. Estimating the burden of invasive and serious fungal disease in the United Kingdom. Journal of Infection, 2016; DOI: 10.1016/j.jinf.2016.10.005

10. Ren, C. Luo, Y. Feng, X. Yao, Z. Shi, F. Liang, J. X. Kang, J.-B. Wan, Z. Pei, H. Su. Omega-3 polyunsaturated fatty acids promote amyloid-  clearance from the brain through mediating the function of the glymphatic system. The FASEB Journal, 2016; DOI: 10.1096/fj.201600896
11. Yuan, G. Wei, Y. You, Y. Huang, H. J. Lee, M. Dong, J. Lin, T. Hu, H. Zhang, C. Zhang, H. Zhou, R. Ye, X. Qi, B. Zhai, W. Huang, S. Liu, W. Xie, Q. Liu, X. Liu, C. Cui, D. Li, J. Zhan, J. Cheng, Z. Yuan, W. Jin. Rutin ameliorates obesity through brown fat activation. The FASEB Journal, 2016; DOI: 10.1096/fj.201600459RR

Harri Hemil�. Vitamin E and the risk of pneumonia: using the I²-statistic to quantify heterogeneity within a controlled trial. British Journal of Nutrition, 2016; 1 DOI: 10.1017/S0007114516003408.

NEWS

Mi-Sung Kim, Sarah A. Krawczyk, Ludivine Doridot, Alan J. Fowler, Jennifer X. Wang, Sunia A. Trauger, Hye-Lim Noh, Hee Joon Kang, John K. Meissen, Matthew Blatnik, Jason K. Kim, Michelle Lai, Mark A. Herman. ChREBP regulates fructose-induced glucose production independently of insulin signaling. Journal of Clinical Investigation, 2016; DOI: 10.1172/JCI81993

Zaidi et al. Vitamin D Deficiency in Medical Inpatients: A Retrospective Study of Implications of Untreated Versus Treated Deficiency. Nutrition and Metabolic Insights 2016:9 65–69 doi:10.4137/NMI.S33747.

Ryan Hutchinson, Abdulhadi Akhtar, Justin Haridas, Deepa Bhat, Claus Roehrborn, Yair Lotan. Testing and referral patterns in the years surrounding the US Preventive Services Task Force recommendation against prostate-specific antigen screening. Cancer, 2016; DOI: 10.1002/cncr.30330

Agatha A. van der Klaauw, Julia M. Keogh, Elana Henning, Cheryl Stephenson, Sarah Kelway, Victoria M. Trowse, Naresh Subramanian, Stephen O’Rahilly, Paul C. Fletcher, I. Sadaf Farooqi. Divergent effects of central melanocortin signalling on fat and sucrose preference in humans. Nature Communications, 2016; 7: 13055 DOI: 10.1038/NCOMMS13055

* theguardian.com/society/2016/oct/19/doctors-know-too-little-about-effects-of-nutrition-and-exercise. Denis Campbell10/20/2016.

BEN BROWN

1. Prasad S, Gupta SC, Tyagi AK, et al. Curcumin, a component of golden spice: from bedside to bench and back. Biotechnol Adv. 2014 Nov 1;32(6):1053-64.
2. September, 2016. http://www.nutraingredients-usa.com/Markets/Turmeric-leads-the-charge-as-herbal-sales-continue-to-bloom
3. Li, S. Y., Yuan, W., Deng, G. R., Wang, P. et al., Chemical composition and product quality control of turmeric (Curcuma longa L.). Pharmaceutical Crops 2011, 2, 28–54.

4.             Kou MC, Chiou SY, Weng CY, Wang L, Ho CT, Wu MJ. Curcuminoids distinctly exhibit antioxidant activities and regulate expression of scavenger receptors and heme oxygenase-1. Mol Nutr Food Res. 2013 Sep;57(9):1598-610.

5. Kiuchi, F.; Goto, Y.; Sugimoto, N.; Akao, N.; Kondo, K.; Tsuda, Y. Nematocidal activity of turmeric: Synergistic action of curuminoids.  Pharm. Bull.1993, 41, 1640–1643

6.             Guo LY, Cai XF, Lee JJ, Kang SS, Shin EM, Zhou HY, Jung JW, Kim YS. Comparison of suppressive effects of demethoxycurcumin and bisdemethoxycurcumin on expressions of inflammatory mediators in vitro and in vivo. Arch Pharm Res. 2008  Apr;31(4):490-6.

7. Aggarwal BB, Yuan W, Li S, Gupta SC. Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric. Mol Nutr Food Res. 2013 Sep;57(9):1529-42.

8.             Madhu K, Chanda K, Saji MJ. Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial. Inflammopharmacology. 2013 Apr;21(2):129-36.9.             Metzler M, Pfeiffer E, Schulz SI, Dempe JS. Curcumin uptake and metabolism. Biofactors. 2013 Jan-Feb;39(1):14-20.10.         Wang K, Qiu F. Curcuminoid metabolism and its contribution to the pharmacological effects. Curr Drug Metab. 2013 Sep;14(7):791-806.

11. Shen L, Liu CC, An CY, Ji HF. How does curcumin work with poor bioavailability? Clues from experimental and theoretical studies. Sci Rep. 2016 Feb 18;6:20872.
12. Jäger R, Lowery RP, Calvanese A, Joy JM, Purpura M, Wilson JM. Comparative absorption of curcumin formulations. Nutr J. 2014;13:1–8

13.         Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6.

14. Al-Karawi D, Al Mamoori DA, Tayyar Y. The Role of Curcumin Administration in Patients with Major Depressive Disorder: Mini Meta-Analysis of Clinical Trials.Phytother Res. 2016 Feb;30(2):175-83.
15. Chassaing B, et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 2015 Mar 5;519(7541):92-6
16. Ng TP, Chiam PC, Lee T, Chua HC, Lim L, Kua EH. Curry consumption and cognitive function in the elderly. Am J Epidemiol. 2006;164:898–906

17.         Hanai H, Iida T, Takeuchi K, et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. 2006 Dec;4(12):1502-6.18.         Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, et al. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014 Mar 20;9:451-819.         Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. 2012 Nov;35(11):2121-7. doi: 10.2337/dc12-0116.

20. Curcumin attenuates severity of premenstrual syndrome symptoms: A randomized, double-blind, placebo-controlled trial

21.         Hishikawa N, Takahashi Y, Amakusa Y, Tanno Y, Tuji Y, Niwa H, Murakami N, Krishna UK. Effects of turmeric on Alzheimer’s disease with behavioral and psychological symptoms of dementia. Ayu. 2012 Oct;33(4):499-504.

MIKE ASH

References

[1] Ménard S, Cerf-Bensussan N, & Heyman M (2010). Multiple facets of intestinal permeability and epithelial handling of dietary antigens. Mucosal immunology, 3 (3), 247-59 PMID: 20404811

[2] Ivanov II, & Littman DR (2010). Segmented filamentous bacteria take the stage. Mucosal immunology, 3 (3), 209-12 PMID: 20147894

[3] T.T. Macdonald and G. Monteleone. Immunity, inflammation, and allergy in the gut. Science 307: 1920–1925, 2005. View Abstract

[4] C. Catassi and A. Fasano. Celiac disease. Curr Opin Gastroenterol 24: 687–691, 2008. View Abstract

[5] O. Vaarala, M.A. Atkinson, and J. Neu. The “perfect storm” for type 1 diabetes: The complex interplay between intestinal microbiota, gut permeability, and mucosal immunity. Diabetes 57: 2555–2562, 2008. View Abstract

[6] Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria.

Neuro Endocrinol Lett. 2008 Dec;29(6):902-10 View Abstract

[7] Maes M, Kubera M, Leunis JC. The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. Neuro Endocrinol Lett. 2008 Feb;29(1):117-24. View Abstract

[8] Macpherson, A.J., McCoy, K.D., Johansen, F.E. & Brandtzaeg, P. The immune geography of IgA induction and function. Mucosal Immunol. 1, 11–22 (2008). View Abstract

[9] Diesner, S.C. et al. Dose-dependent food allergy induction against ovalbumin under acid-suppression: a murine food allergy model. Immunol. Lett. 121, 45–51 (2008). View Full Paper

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[11] Bijlsma, P.B. et al. Differential in vivo and in vitro intestinal permeability to lactulose and mannitol in animals and humans: a hypothesis. Gastroenterology 108, 687–696 (1995). View Abstract

[12] Matysiak-Budnik, T. et al. Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease. J. Exp. Med. 205, 143–154 (2008). View Abstract

[13] Rook GA, Brunet LR.  Microbes, immunoregulation, and the gut. Gut. 2005 Mar;54(3):317-20. Review. View Full Paper

[14] Pohjavuori E, Viljanen M, Korpela R, Kuitunen M, Tiittanen M, Vaarala O, Savilahti E. Lactobacillus GG effect in increasing IFN-gamma production in infants with cow’s milk allergy. J Allergy Clin Immunol. 2004 Jul;114(1):131-6. View Abstract

[15] Favre, L., Spertini, F. & Corthesy, B. Secretory IgA possesses intrinsic modulatory properties stimulating mucosal and systemic immune responses. J. Immunol. 175, 2793–2800 (2005). View Abstract

[16] Nose K, Yang H, Sun X, Nose S, Koga H, Feng Y, Miyasaka E, Teitelbaum DH. Glutamine prevents total parenteral nutrition-associated changes to intraepithelial lymphocyte phenotype and function: a potential mechanism for the preservation of epithelial barrier function. J Interferon Cytokine Res. 2010 Feb;30(2):67-80. View Abstract

[17] Playford RJ, Woodman AC, Clark P, Watanapa P, Vesey D, Deprez PH, Williamson RC, Calam J.

Effect of luminal growth factor preservation on intestinal growth. Lancet. 1993 Apr 3;341(8849):843-8. View Abstract

[18] Langmead L, Dawson C, Hawkins C, Banna N, Loo S, Rampton DS. Antioxidant effects of herbal therapies used by patients with inflammatory bowel disease: an in vitro study. Aliment Pharmacol Ther. 2002 Feb;16(2):197-205. View Abstract

[19] Parcell S. Sulfur in human nutrition and applications in medicine. Altern Med Rev. 2002 Feb;7(1):22-44. Review. View Paper

DIGESTION RESEARCH

Milda Stuknytė, Margherita Maggioni, Stefano Cattaneo, Paola De Luca, Amelia Fiorilli, Anita Ferraretto, Ivano De Noni. Release of wheat gluten exorphins A5 and C5 during in vitro gastrointestinal digestion of bread and pasta and their absorption through an in vitro model of intestinal epithelium. Food Research International, 2015; 72: 208 DOI: 10.1016/j.foodres.2015.04.002.

Matthew Weiser, Jeremy M Simon, Bharati Kochar, Adelaide Tovar, Jennifer W Israel, Adam Robinson, Gregory R Gipson, Matthew S Schaner, Hans H Herfarth, R Balfour Sartor, Dermot P B McGovern, Reza Rahbar, Timothy S Sadiq, Mark J Koruda, Terrence S Furey, Shehzad Z Sheikh. Molecular classification of Crohn’s disease reveals two clinically relevant subtypes. Gut, October 2016 DOI: 10.1136/gutjnl-2016-312518.

Antonio Gonzalez, Embriette Hyde, Naseer Sangwan, Jack A. Gilbert, Erik Viirre, Rob Knight. Migraines Are Correlated with Higher Levels of Nitrate-, Nitrite-, and Nitric Oxide-Reducing Oral Microbes in the American Gut Project Cohort. mSystems, October 2016 DOI: 10.1128/mSystems.00105-16.

GREEN FOODS

Turmeric tea study:
Dias, I., Ademowo, O., Newey, E. and Griffiths, H. (2015). The Nrf2-ARE activation protect neurones against oxidative stress. Free Radical Biology and Medicine, 86, pp.S30-S31.
Hawkey, C. (2001). COX-1 and COX-2 inhibitors. Best Practice & Research Clinical Gastroenterology, 15(5), pp.801-820.
Lee, J. (2005). Nrf2, a multi-organ protector? The FASEB Journal, 19(9), pp.1061-1066.
Aggarwal B.B, Ichikawa H., Garodia P., Weerasinghe P., Sethi G., Bhatt I.D., Pandey M.K., Shishodia S., Nair M.G. From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer. Expert Opin Ther Targets 2006;10(1):87-118.
Aggarwal B.B., Sundaram C., Malani N., Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol. 2007;595:1-75.
Aggarwal B.B., Yuan W., Li S., Gupta S.C. Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric. Mol Nutr Food Res. 2013;57(9):1529-42.
Potential role of herbal remedies in stem cell therapy: proliferation and differentiation of human mesenchymal stromal cells. Vindya Lankika Udalamaththa, Chanika Dilumi Jayasinghe and Preethi Vidya Udagama. Stem Cell Research & Therapy2016,7:110. DOI: 10.1186/s13287-016-0366-4.

RESEARCH
L.N. Yelland, B.J. Gajewski, J. Colombo, R.A. Gibson, M. Makrides, S.E. Carlson. Predicting the effect of maternal docosahexaenoic acid (DHA) supplementation to reduce early preterm birth in Australia and the United States using results of within country randomized controlled trials. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2016; 112: 44 DOI: 10.1016/j.plefa.2016.08.007

Cherrie L. Small, Lydia Xing, Joseph B. McPhee, Hong T. Law, Brian K. Coombes. Acute Infectious Gastroenteritis Potentiates a Crohn’s Disease Pathobiont to Fuel Ongoing Inflammation in the Post-Infectious Period. PLOS Pathogens, 2016; 12 (10): e1005907 DOI: 10.1371/journal.ppat.1005907

Malgorzata Dobosz-Bartoszek, Mark H. Pinkerton, Zbyszek Otwinowski, Srinivas Chakravarthy, Dieter Söll, Paul R. Copeland, Miljan Simonović. Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation. Nature Communications, 2016; 7: 12941 DOI: 10.1038/ncomms12941

Shu G. Chen, Vilius Stribinskis, Madhavi J. Rane, Donald R. Demuth, Evelyne Gozal, Andrew M. Roberts, Rekha Jagadapillai, Ruolan Liu, Kyonghwan Choe, Bhooma Shivakumar, Francheska Son, Shunying Jin, Richard Kerber, Anthony Adame, Eliezer Masliah, Robert P. Friedland. Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans. Scientific Reports, 2016; 6: 34477 DOI: 10.1038/srep34477.

Madhusudana Rao Chikka, Charumathi Anbalagan, Katherine Dvorak, Kyle Dombeck, Veena Prahlad. The Mitochondria-Regulated Immune Pathway Activated in the C. elegans Intestine Is Neuroprotective. Cell Reports, 2016; 16 (9): 2399 DOI: 10.1016/j.celrep.2016.07.077

Shiran Salomon-Zimri, Micaela Johanna Glat, Yael Barhum, Ishai Luz, Anat Boehm-Cagan, Ori Liraz, Tali Ben-Zur, Daniel Offen, Daniel M. Michaelson. Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment. Journal of Alzheimer’s Disease, Volume 53, Number 4, 2016; Pages 1443-1458.

Marc A. Mitchell, David D. Wartinger. Validation of a Functional Pyelocalyceal Renal Model for the Evaluation of Renal Calculi Passage While Riding a Roller Coaster. The Journal of the American Osteopathic Association, 2016; 116 (10): 647 DOI: 10.7556/jaoa.2016.128

Michelle Beaumont, Julia K. Goodrich, Matthew A. Jackson, Idil Yet, Emily R. Davenport, Sara Vieira-Silva, Justine Debelius, Tess Pallister, Massimo Mangino, Jeroen Raes, Rob Knight, Andrew G. Clark, Ruth E. Ley, Tim D. Spector, Jordana T. Bell. Heritable components of the human fecal microbiome are associated with visceral fat. Genome Biology, 2016; 17 (1) DOI: 10.1186/s13059-016-1052-7.

Joseph P Zackular, Jessica L Moore, Ashley T Jordan, Lillian J Juttukonda, Michael J Noto, Maribeth R Nicholson, Jonathan D Crews, Matthew W Semler, Yaofang Zhang, Lorraine B Ware, M Kay Washington, Walter J Chazin, Richard M Caprioli, Eric P Skaar. Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection. Nature Medicine, 2016; DOI: 10.1038/nm.4174.

Jian Zhen Ou, Jeremy J. Cottrell, Nam Ha, Naresh Pillai, Chu K. Yao, Kyle J. Berean, Stephanie A. Ward, Danilla Grando, Jane G. Muir, Christopher J. Harrison, Udani Wijesiriwardana, Frank R. Dunshea, Peter R. Gibson, Kourosh Kalantar-zadeh. Potential of in vivo real-time gastric gas profiling: a pilot evaluation of heat-stress and modulating dietary cinnamon effect in an animal model. Scientific Reports, 2016; 6: 33387 DOI: 10.1038/srep33387.

Somadina Emineke, Alan J Cooper, Sarah Fouch, Brian R Birch, Bashir A Lwaleed. Diluted honey inhibits biofilm formation: potential application in urinary catheter management? Journal of Clinical Pathology, 2016; jclinpath-2015-203546 DOI: 10.1136/jclinpath-2015-203546

NEWS

CFS/PACE
2011 PACE paper in The Lancet:
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)60096-2/fulltext.
PACE authors’ new analyses:
http://www.wolfson.qmul.ac.uk/image…otocol_based_analysis_final_8th_Sept_2016.pdf.

Robert K. Naviaux et al. Metabolic features of chronic fatigue syndrome. PNAS 2016, vol. 113: 37, E5472–E5480. doi: 10.1073/pnas.1607571113.

Robert K. Naviaux, Metabolic features of the cell danger response. Mitochondrion, Volume 16, May 2014, Pages 7–17. http://dx.doi.org/10.1016/j.mito.2013.08.006.

NEW RELEASES

Castro-Marrero Jesús, Cordero Mario D., Segundo María José, Sáez-Francàs Naia, Calvo Natalia, Román-Malo Lourdes, Aliste Luisa, Fernández de Sevilla Tomás, and Alegre José.

Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in Chronic Fatigue Syndrome? Antioxidants & Redox Signaling. March 10, 2015, 22(8): 679-685. doi:10.1089/ars.2014.6181.

Cannabidiol Reduces The Anxiety Induced By Simulated Public Speaking In Treatment-Naïve Social Phobia Patients”. MM Bergamaschi, Department of Neuroscience and Behavior, School of Medicine of Ribeirão Preto, University of São Paulo, SP, Brazil.

Neuropsychopharmacology, May 2011

“Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing”. P Fusar-Poli, Neuroimaging Section, Division of Psychological Medicine, Institute of Psychiatry, London. Archives of General Psychiatry, January 2009.

BEN BROWN

1.             Sies H, Stahl W, Sevanian A. Nutritional, dietary and postprandial oxidative stress. J Nutr. 2005 May;135(5):969-72.

2. Zilversmit, D. B. (1979) Atherogenesis: a postprandial phenomenon. Circulation60:473-485.

3.             O’Keefe JH, Gheewala NM, O’Keefe JO. Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. J Am Coll Cardiol. 2008 Jan 22;51(3):249-55.

4. O’Keefe JH, Bell Postprandial hyperglycemia/hyperlipidemia (postprandial dysmetabolism) is a cardiovascular risk factor. Am J Cardiol. 2007;100(5):899–904.

5.             Bloomer RJ, Kabir MM, Marshall KE, Canale RE, Farney TM. Postprandial oxidative stress in response to dextrose and lipid meals of differing size. Lipids Health Dis. 2010 Jul 27;9:79.

6. laak EE, et al. Impact of postprandial glycaemia on health and prevention of disease. Obes Rev. 2012 Oct;13(10):923-84.

7.             Monnier L, Mas E, Ginet C, Michel F, Villon L, Cristol JP, Colette C. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA. 2006 Apr  12;295(14):1681-7.

8. Tominaga M, Eguchi H, Manaka H, Igarashi K, Kato T, Sekikawa A. Impaired glucose tolerance is a risk factor for cardiovascular disease, but not impaired fasting glucose. The Funagata Diabetes Study. Diabetes Care 1999;22:920 –924.
9. Mellen PB, Bittner V, Herrington DM. Post-challenge glucose predicts coronary atherosclerotic progression in non-diabetic, post-menopausal women. Diabet Med. 2007;24(10):1156-1159

10.         O’Keefe JH, Abuannadi M, Lavie CJ, Bell DS. Strategies for optimizing glycemic control and cardiovascular prognosis in patients with type 2 diabetes mellitus. Mayo Clin Proc. 2011 Feb;86(2):128-38.

11. Nichols GA, Hillier TA, Brown JB. Normal fasting plasma glucose and risk of type 2 diabetes diagnosis. Am J Med 2008;121:519 –524.

12.         Huang CL, Chang HW, Chang JB, Chen JH, Lin JD, Wu CZ, Pei D, Hung YJ, Lee CH,  Chen YL, Hsieh CH. Normal fasting plasma glucose predicts type 2 diabetes and cardiovascular disease in elderly population in Taiwan. QJM. 2016 Aug;109(8):515-22.13.         Hsiao FC, Hsieh CH, Wu CZ, Hsu CH, Lin JD, Lee TI, Pei D, Chen YL. Elevated fasting glucose levels within normal range are associated with an increased risk  of metabolic syndrome in older women. Eur J Intern Med. 2013 Jul;24(5):425-9.14.         Feinman RD, Pogozelski WK, Astrup A, Bernstein RK, Fine EJ, Westman EC, Accurso A, Frassetto L, Gower BA, McFarlane SI, Nielsen JV, Krarup T, Saslow L, Roth KS, Vernon MC, Volek JS, Wilshire GB, Dahlqvist A, Sundberg R, Childers A, Morrison K, Manninen AH, Dashti HM, Wood RJ, Wortman J, Worm N. Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base. Nutrition. 2015 Jan;31(1):1-13.

15. Official Statistics. National Diet and Nutrition Survey: results from Years 1 to 4 (combined) of the rolling programme for 2008 and 2009 to 2011 and 2012. From: Public Health Englandand Food Standards Agency. First published: 14 May 2014

16.         Minich DM, Bland JS. Dietary management of the metabolic syndrome beyond macronutrients. Nutr Rev. 2008 Aug;66(8):429-44.

17. Violi F, et al. Extra virgin olive oil use is associated with improved post-prandial blood glucose and LDL cholesterol in healthy subjects. Nutr Diabetes. 2015 Jul 20;5:e172.
18. Wien M, et al. A randomized 3×3 crossover study to evaluate the effect of Hass avocado intake on post-ingestive satiety, glucose and insulin levels, and subsequent energy intake in overweight adults. Nutr J. 2013 Nov 27;12:155.
19. Beejmohun V, et al. Acute effect of Ceylon cinnamon extract on postprandial glycemia: alpha-amylase inhibition, starch tolerance test in rats, and randomized crossover clinical trial in healthy volunteers. BMC Complement Altern Med. 2014 Sep 23;14:351.
20. Shimabukuro M, et al. Effects of the brown rice diet on visceral obesity and endothelial function: the BRAVO study. Br J Nutr. 2014 Jan 28;111(2):310-20.
21. Thompson SV, Winham DM, Hutchins AM. Bean and rice meals reduce postprandial glycemic response in adults with type 2 diabetes: a cross-over study. Nutr J. 2012 Apr 11;11:23.
22. Josse AR, Kendall CW, Augustin LS, Ellis PR, Jenkins DJ. Almonds and postprandial glycemia–a dose-response study. Metabolism. 2007 Mar;56(3):400-4.
23. Ostman E, et al. Vinegar supplementation lowers glucose and insulin responses and increases satiety after a bread meal in healthy subjects. Eur J Clin Nutr. 2005 Sep;59(9):983-8.

24.         Dunstan DW, Kingwell BA, Larsen R, Healy GN, Cerin E, Hamilton MT, Shaw JE, Bertovic DA, Zimmet PZ, Salmon J, Owen N. Breaking up prolonged sitting reduces postprandial glucose and insulin responses. Diabetes Care. 2012 May;35(5):976-83.

BRAIN HEALTH – PATRICK HOLFORD

1. Council for Evidence-based Psychiatry (CEP), 2013 data; cepuk.org/2015/04/10/latest-prescription-data-shows-consumption-psychiatric-drugs-continues-soar/
2. C. Coupland et al., ‘Antidepressant use and risk of adverse outcomes in older people: population-based cohort study’, British Medical Journal (2011), 2 Aug; 343: d4,551; www.ncbi.nlm.nih.gov/pubmed/21810886
3. Seewww.telegraph.co.uk/news/health/news/12126146/Antidepressants-can-raise-the-risk-of-suicide-biggest-ever-review-finds.html; also T. Sharma et al., ‘Suicidality and aggression during antidepressant treatment: systematic review and meta-analyses based on clinical study reports’, British Medical Journal (2016), 27 Jan; 352: i65; www.ncbi.nlm.nih.gov/pubmed/26819231
4. M. Pirmohamed et al., ‘Adverse drug reactions as cause of admission to hospital: prospective analysis of 18,820 patients’, British Medical Journal(2004), 3 Jul; 329(7,456): 15–19; www.ncbi.nlm.nih.gov/pubmed/15231615
5. ‘Medical error is the fifth-leading cause of death in the US’, Medical News Today, Jun. 2007;www.medicalnewstoday.com/releases/75042.php
6. M.A. Makary and M. Daniel, ‘Medical error: the third leading cause of death in the US’, BMJ(2016); May 3; 353: i2,139
7. J. Le Noury et al., ‘Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence’, British Medical Journal(2015); 351: h4,320; study329.org/wp-content/uploads/2015/09/Study-329-Final.pdf
8. Seecepuk.org/.
9. Seesecure.avaaz.org/en/petition/Stop_Drug_Companies_Killing_for_Profits/%5D.
10. Seewww.dailymail.co.uk/health/article-3234334/Prescription-pills-Britain-s-biggest-killer-effects-drugs-taken-insomnia-anxiety-kill-thousands-doctors-hand-like-Smarties.html#ixzz3mAz6KDRz.
11. Seewww.youtube.com/watch?v=_9cfjKOmPF8.
12. A.D. Smith and K. Yaffe, ‘Dementia can be prevented: statement supported by international experts’, Journal of Alzheimer’s Disease38 (2014); 699–703; file:///Users/admin/Downloads/igedpreventionstatementg8_2014__2_.pdf
13. M. Beydoun et al., ‘Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis’, BMC Public Health(2014), 14: 643; bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-14-643
14. The research councils spent £156,000. For Food for the Brain’s campaign, seewww.foodforthebrain.org/alzheimers-prevention.aspx.
15. M.A. Arroll et al., ’Nutritional interventions for the adjunctive treatment of schizophrenia: a brief review’, Nutr. J.(2014), 16 Sep;www.ncbi.nlm.nih.gov/pubmed/25228271
16. J. Sarris et al., ‘Nutritional medicine as mainstream in psychiatry’, The Lancet(2015); 23), 271–4; dx.doi.org/10.1016/S2215-036614)00051-0

ADAPTATION – CHRIS NEWBOLD

2 Chopra D, Tanzi RE. Supergenes. 2015. UK: Penguin

3 Previc F The Dopaminergic Mind in Human Evolution and History 2009; Cambridge University Press

4 Abdulamir HA1, Abdul-Rasheed OF, Abdulghani EA. “Low oxytocin and melatonin levels and their possible role in the diagnosis and prognosis in Iraqi autistic children.“Saudi Med J. 2016 Jan;37(1):29-36. doi: 10.15537/smj.2016.1.13183.

5 McEwan Neuroimage 2009;47(3):911-913

6 Jankord. Ann N Y Acad Sci 2008;148:64-73

7 Sapolsky R M Why zebras don’t get ulcers 1998 W H Freeman and Co USA

8 Babri et al. Strain-dependent effects of prenatal maternal immune activation on anxiety- and depression-like behaviors in offspring. Brain Behav Immun. 2014 Mar;37:164-76.

9 Weir. Autism, schizophrenia and other disorders may have roots in life’s earliest stages. Monitor on Psychology February 2012, Vol 43, No. 2

10 Marques et al. The influence of maternal prenatal and early childhood nutrition and maternal prenatal stress on offspring immune system development and neurodevelopmental disorders. Front Neurosci. 2013; 7: 120.

11 Botiglieri S-Adenosyl-L-methionine (SAMe): from the bench to the bedside—molecular basis of a pleiotrophic molecule. Am J Clin Nutr November 2002  vol. 76 no. 5 1151S-1157S

12 Sabol SZ et al. A functional polymorphism in the monoamine oxidase A gene promoter. Human Genet. 1998; 103(3): 273–279.

13 Meyer JH et al. Elevated monoamine oxidase a levels in the brain: an Explanation for the monoamine imbalance of major depression. Arch Gen Psychiatry. 2006; 63(11):1209-1216.

14 Zhang Y et al. A meta-analysis on relationship of MAOB intron 13 polymorphisms, interactions with smoking/COMT H158L polymorphisms with the risk of PD. Int J Neurosci. 2016; 126(5): 400-7.

15 Cohen IL et al. Autism severity is associated with child and maternal MAOA genotypes. Clinical Genet. 2011; 79 (4): 355-362.

16 Genetics Home Reference. COMT. 2007. Available at: http://ghr.nlm.nih.gov/gene/COMT

17 Hettema JM et al. COMT contributes to genetic susceptibility shared among anxiety spectrum phenotypes. Biol Psychiatry. 2008; 64(4): 302–310.

18 Pandolfo G et al. Association of the COMT synonymous polymorphism Leu136Leu and missense variant Vak158Met with mood disorders. J Affect Disord. 2015; 177:108-113.

19 Mandelli L et al.  Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders. Int.J.Neuropsychopharmacol. 2007; 10 (4): 437-447.

20 Hallehand H et al. Association between catechol-O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults. Am J Med Genet B Neuropsychiatr Genet. 2009;150B(3):403-410.

21 Simpson EH et al. Genetic variation in COMT activity impacts learning and dopamine release capacity in the striatum. Learn Mem. 2014; 21(4): 205–214.

22 Cengiz FB et al. Genetic polymorphism of the serotonin transporter gene, SLC6A4 rs16965628, is associated with obsessive compulsive disorder. Genet Test Mol Biomarkers. 2015; 19 (5): 228-234.

23 Juhan, D. Job’s Body: A Handbook for Bodywork. Barrytown; Station Hill Press.

LIGHT SENSITIVITY CASE HISTORY – JENNIFER WILLIAMS

1. Kukkonen K, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T,Tuure T, Kuitunen M (2007) Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: A randomized, double-blind, placebo-controlled Journal of Allergy and Clinical Immunology 119:192-8.

2. Mizuguchi D, Das H, Matsushita AK, Maeyama C, Umehara K, Ohtoshi T, Kojima J, Nishida K, Takahashi K,Fukui, H (2008). Suppression of histamine signaling by probiotic Lac-B: a possible mechanism of its anti-allergic Journal of Pharmacological Sciences, 107:159-166.

3. DeAngelis YM, Gemmer CM, Kaczvinsky, JR, Kenneally DC, Schwartz JR, Dawson Jr TL (2005) Three etiologic facets of dandruff and seborrheic dermatitis: malassezia fungi, sebaceous lipids and individual Journal of Investigative Dermatology Symposium  Proceedings,

10:295–297.

4. Tollesson A, Frithz A, Berg A, Karlman G (1993) Essential fatty acids in infantile seborrheic dermatitis. Journal of the American Academy of Dermatology, 28: 957-961.

• Preuss CV, Wood TC, Szumlanski CL, Raftogianis RB, Otterness DM, Girard B, Scott MC, Weinshilboum RM (1998) Human histamine n-methyltransferase pharmacogenetics: common genetic polymorphisms that alter Molecular Pharmacology, 53:708-17.

6. Barbosa PR, Stabler SP, Machado ALK, Braga RC, Hirata RDC, Hirata MH, Sampaio-Neto LF, Allen RH, Guerra-Shinohara EM (2007) Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant European Journal of Clinical Nutrition, 62:1010–1021.
7. Lewis CA (2015) Enteroimmunology: a guide to the prevention and treatment of chronic inflammatory Carrabelle, Florida: Psy Press.
8. McGuire M, Beerman KA (2015) 3rd Nutritional sciences:from fundamentals to food.

Belmont, California: Wadsworth, Cengage Learning.

9. Bolander-Gouaille C (2002) 2nd Focus on homocysteine and the vitamins involved in its metabolism: involved in its metabolism.France:Springer.
10. Zeisel SH (2006) Choline: Critical role during fetal development and dietary requirements in adults. Annual Review of Nutrition, 26: 229-250.
11. Mitchell ES, Conus N, Kaput J (2014) B vitamin polymorphisms and behavior: Evidence of associations with neurodevelopment, depression, schizophrenia, bipolar disorder and cognitive decline. Neuroscience & Biobehavioral Reviews, 47: 307–320.

• Snpedia (2016) Yasko Accessed:http://www.snpedia.com/index.php/Yasko_Methylation#MAOA_Gene 7th April   2016.

13. University of Bristol, centre for academic primary care. MYMOP general information. [Online]Available at: http://www.bristol.ac.uk/primaryhealthcare/resources/mymop/general- information/

RESEARCH
Lien Wang, Yan Zhang, Zhiwei Wang, Nian Gong, Tae Dong Kweon, Benjamin Vo, Chaoran Wang, Xiuli Zhang, Jae Yoon Chung, Amal Alachkar, Xinmiao Liang, David Z. Luo, Olivier Civelli. The Antinociceptive Properties of the Corydalis yanhusuo Extract. PLOS ONE, 2016; 11 (9): e0162875 DOI: 10.1371/journal.pone.0162875

10. A. Lopez, B. M. Miller, F. Rivera-Chavez, E. M. Velazquez, M. X. Byndloss, A. Chavez-Arroyo, K. L. Lokken, R. M. Tsolis, S. E. Winter, A. J. Baumler. Virulence factors enhance Citrobacter rodentium expansion through aerobic respiration. Science, 2016; 353 (6305): 1249 DOI: 10.1126/science.aag3042

Freddie C. Hamdy, et al. 10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer. New England Journal of Medicine, 2016; DOI: 10.1056/NEJMoa1606220

Jenny L. Donovan, et al. Patient-Reported Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer. New England Journal of Medicine, 2016; DOI: 10.1056/NEJMoa1606221

Mathias Rask-Andersen, David Martinsson, Muhammad Ahsan, Stefan Enroth, Weronica E Ek, Ulf Gyllensten, Åsa Johansson. Epigenome Wide Association Study Reveals Differential DNA Methylation in Individuals With a History of Myocardial Infarction. Human Molecular Genetics, 2016; ddw302 DOI: 10.1093/hmg/ddw302

Antonios Chronopoulos, Benjamin Robinson, Muge Sarper, Ernesto Cortes, Vera Auernheimer, Dariusz Lachowski, Simon Attwood, Rebeca García, Saba Ghassemi, Ben Fabry, Armando del Río Hernández. ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion. Nature Communications, 2016; 7: 12630 DOI: 10.1038/ncomms12630

Adrian R Martineau, Christopher J Cates, Mitsuyoshi Urashima, Megan Jensen, Alex P Griffiths, Ulugbek Nurmatov, Aziz Sheikh, Chris J Griffiths. Vitamin D for the management of asthma. Cochrane Library, 2016 DOI: 10.1002/14651858.CD011511.pub2.

Nupur Bhattacharya et al. Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8 T Cell-Mediated Immunity in Colorectal Cancer. Immunity, August 2016 DOI: 10.1016/j.immuni.2016.08.008

Stephen P. Juraschek, Allan C. Gelber, Hyon K. Choi, Lawrence J. Appel, Edgar R. Miller. Effects of the Dietary Approaches To Stop Hypertension (DASH) Diet and Sodium Intake on Serum Uric Acid. Arthritis & Rheumatology, 2016; DOI: 10.1002/art.39813

NEWS

Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis . A. Trovato et al. Immunity & Ageing201613:23

DOI: 10.1186/s12979-016-0078-8

Changes in Burnout and Satisfaction With Work-Life Balance in Physicians and the General US Working Population Between 2011 and 2014.

Shanafelt, Tait D. et al. Mayo Clinic Proceedings 2016, Volume 90 , Issue 12 , 1600-13.

Clinical research evidence of cupping therapy in China: a systematic literature review

Huijuan Cao¹, Mei Han¹, Xun Li¹, Shangjuan Dong¹, Yongmei Shang¹, Qian Wang¹, Shu Xu¹ and Jianping Liu

BMC Complementary and Alternative MedicineThe official journal of the International Society for Complementary Medicine Research (ISCMR)201010:70

DOI: 10.1186/1472-6882-10-70.
Journal of Traditional Chinese Medical Sciences

Volume 1, Issue 1, 1 July 2014, Pages 49–61. Cupping therapy for acute and chronic pain management: a systematic review of randomized clinical trials

Huijuan Caoa, Xun Lia, Xue Yanb, Nissi S. Wangc, Alan Bensoussand, Jianping Liua, et al. doi:10.1016/j.jtcms.2014.11.003.

Serum and retinal responses to three different doses of macular carotenoids over 12 weeks of supplementation. Experimental Eye Research, Volume 151, October 2016, Pages 1-8.  James M. Stringham, Nicole T. Stringham.

Eleanor Pullenayegum, PhD et al. Live Attenuated Versus Inactivated Influenza Vaccine in Hutterite Children: A Cluster Randomized Blinded Trial. Annals of Internal Medicine, August 2016 DOI: 10.7326/M16-0513.

Bobak Heydari, et al. Effect of Omega-3 Acid Ethyl Esters on Left Ventricular Remodeling After Acute Myocardial InfarctionClinical Perspective. Circulation, 2016; 134 (5): 378 DOI: 10.1161/CIRCULATIONAHA.115.019949

BEN BROWN
1. Dash SR, O’Neil A, Jacka FN. Diet and Common Mental Disorders: The Imperative to Translate Evidence into Action. Front Public Health. 2016 Apr 29;4:81.

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5. Brundin L, Erhardt S, Bryleva EY, Achtyes ED, Postolache TT. The role of inflammation in suicidal behaviour. Acta Psychiatr Scand. 2015 Sep;132(3):192-203.
6. Gibbs HM, Davis L, Han X, Clothier J, Eads LA, Cáceda R. Association between C-reactive protein and suicidal behavior in an adult inpatient population. J Psychiatr Res. 2016 Aug;79:28-33.
7. Miller AH, Maletic V, Raison CL. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry. 2009 May 1;65(9):732-41.
8. Berk M, Williams LJ, Jacka FN, O’Neil A, Pasco JA, Moylan S, Allen NB, Stuart AL, Hayley AC, Byrne ML, Maes M. So depression is an inflammatory disease, but where does the inflammation come from? BMC Med. 2013 Sep 12;11:200.
9. Tanskanen A, Hibbeln JR, Hintikka J, Haatainen K, Honkalampi K, Viinamäki H. Fish consumption, depression, and suicidality in a general population. Arch Gen Psychiatry. 2001 May;58(5):512-3.
10. Huan M, Hamazaki K, Sun Y, Itomura M, Liu H, Kang W, Watanabe S, Terasawa K, Hamazaki T. Suicide attempt and n-3 fatty acid levels in red blood cells: a case control study in China. Biol Psychiatry. 2004 Oct 1;56(7):490-6.
11. Shivappa N, Schoenaker DA, Hebert JR, Mishra GD. Association between inflammatory potential of diet and risk of depression in middle-aged women: the Australian Longitudinal Study on Women’s Health. Br J Nutr. 2016 Aug 8:1-10. [Epub ahead of print]
12. Hawton K, van Heeringen K. Suicide. Lancet 2009; 373: 1372–81.
13. Stahl ST, Albert SM, Dew MA, Lockovich MH, Reynolds CF 3rd. Coaching in healthy dietary practices in at-risk older adults: a case of indicated depression prevention. Am J Psychiatry. 2014 May;171(5):499-505.
14. Nanri A, Mizoue T, Poudel-Tandukar K, Noda M, Kato M, Kurotani K, Goto A, Oba S, Inoue M, Tsugane S; Japan Public Health Center-based Prospective Study Group. Dietary patterns and suicide in Japanese adults: the Japan Public Health Center-based Prospective Study. Br J Psychiatry. 2013 Dec;203(6):422-7.
15. Opie RS, Itsiopoulos C, Parletta N, Sanchez-Villegas A, Akbaraly TN, Ruusunen  A, Jacka FN.Dietary recommendations for the prevention of depression.Nutr Neurosci. 2015 Aug 28. [Epub ahead of print]
16. Van der Borght K, Köhnke R, Göransson N, Deierborg T, Brundin P, Erlanson-Albertsson C, Lindqvist A. Reduced neurogenesis in the rat hippocampus following high fructose consumption. Regul Pept. 2011 Feb 25;167(1):26-30.
17. Pan X, Zhang C, Shi Z. Soft drink and sweet food consumption and suicidal behaviours among Chinese adolescents. Acta Paediatr. 2011 Nov;100(11):e215-22.
18. Solnick SJ, Hemenway D. Soft drinks, aggression and suicidal behaviour in US high school students. Int J Inj Contr Saf Promot. 2014;21(3):266-73.
19. Shi Z, Taylor AW, Wittert G, Goldney R, Gill TK. Soft drink consumption and mental health problems among adults in Australia. Public Health Nutr. 2010 Jul;13(7):1073-9.
20. Al-Karawi D, Al Mamoori DA, Tayyar Y. The Role of Curcumin Administration in Patients with Major Depressive Disorder: Mini Meta-Analysis of Clinical Trials. Phytother Res. 2016 Feb;30(2):175-83.
21. McNamara RK. Long-chain omega-3 fatty acid deficiency in mood disorders: rationale for treatment and prevention. Curr Drug Discov Technol. 2013 Sep;10(3):233-44.
22. Sublette ME, Hibbeln JR, Galfalvy H, Oquendo MA, Mann JJ. Omega-3 polyunsaturated essential fatty acid status as a predictor of future suicide risk. Am J Psychiatry. 2006 Jun;163(6):1100-2.
23. Marriott BP, Hibbeln JR, Killeen TK, Magruder KM, Holes-Lewis K, Tolliver BK, Turner TH; BRAVO Group. Design and methods for the Better Resiliency Among Veterans and non-Veterans with Omega-3s (BRAVO) study: A double blind, placebo-controlled trial of omega-3 fatty acid supplementation among adult individuals at risk of suicide. Contemp Clin Trials. 2016 Mar;47:325-33.
24. Shaffer JA, Edmondson D, Wasson LT, Falzon L, Homma K, Ezeokoli N, Li P,Davidson KW. Vitamin D supplementation for depressive symptoms: a systematic review and meta-analysis of randomized controlled trials. Psychosom Med. 2014 Apr;76(3):190-6.
25. Grudet C, Malm J, Westrin A, Brundin L. Suicidal patients are deficient in vitamin D, associated with a pro-inflammatory status in the blood. Psychoneuroendocrinology. 2014 Dec;50:210-9.

ANTIOXIDANTS

G J McBean, M G López and F K Wallner. Redox-based therapeutics in neurodegenerative disease. British Journal of Pharmacology, 1 AUG 2016 DOI: 10.1111/bph.13551.

Do You Know The Power of the Nrf2 Pathway? http://www.drperlmutter.com/good-news-nrf2/?hvid=4LdnJk.

Egner PA, et al. (2014) Rapid and sustainable detoxication of airborne pollutants by

broccoli sprout beverage: Results of a randomized clinical trial in China. Cancer Prev

Res (Phila) 7(8):813-823.
Kensler TW, et al. (2013) Keap1-nrf2 signaling: a target for cancer prevention by

sulforaphane. Top Curr Chem 329:163-177.
Clin Pharmacol. 2014 Feb 3;6:19-34. doi: 10.2147/CPAA.S35078. eCollection 2014.

The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders. Gao B1, Doan A1, Hybertson BM1. Free online at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917919.

Kanwaljit Singh, Susan L. Connors, Eric A. Macklin, Kirby D. Smith, Jed W. Fahey, Paul Talalay, and Andrew W. Zimmerman. Sulforaphane treatment of autism spectrum disorder (ASD). PNAS, October 13, 2014 DOI: 10.1073/pnas.1416940111.

Saskia F. Erttmann, Anetta Hartlova, Marta Sloniecka, Faizal A.M. Raffi, Ava Hosseinzadeh, Tomas Edgren, Reza Rofougaran, Ulrike Resch, Maria Fällman, Torben Ek, and Nelson O. Gekara. Loss of the DNA Damage Repair Kinase ATM Impairs Inflammasome-Dependent Anti-Bacterial Innate Immunity. Immunity, 2016 DOI: 10.1016/j.immuni.2016.06.018.

Trends Cell Biol. 2011 Oct; 21(10): 569–576.

Published online 2011 Aug 6. doi:  10.1016/j.tcb.2011.06.008

Taking a “good” look at free radicals in the aging process

Siegfried Hekimi,* Jérôme Lapointe, and Yang Wen, free online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074523.

Circulation. 2013 May 7;127(18):1888-902. doi: 10.1161/CIRCULATIONAHA.112.132159. Epub 2013 Apr 5. NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. Gray SP¹, Di Marco E, Okabe J, Szyndralewiez C, Heitz F, Montezano AC, de Haan JB, Koulis C, El-Osta A, Andrews KL, Chin-Dusting JP, Touyz RM, Wingler K, Cooper ME, Schmidt HH, Jandeleit-Dahm KA.

CHRIS MELETIS – ENERGY
References:

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2. Strushkevich N, et al. Proc Natl Acad Sci USA. 2011 Jun 21;108(25):10139-43.
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IHCAN Student

1. Kirby E D et al. Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2. eLife 2013, 2: 1-23. http://doi.org/10.7554/eLife.00362
2. Cahill L et al. Enhanced human memory consolidation with post-learning stress: interaction with the degree of arousal at encoding. Learn. Mem 2003. 10, 270–274. 10.1101/lm.62403
3. Rogers CR, A way of being. Boston: Houghton Mifflin Company, 1995.
4. Clifford D and Curtis L, Motivational interviewing in nutrition and fitness. The Guildford Press, 2016
5. Gardner B et al. Making health habitual: the psychology of “habit-formation” and general practice.The British Journal of General Practice 2012, 62: 664–666.

RESEARCH

Yassine HN, Rawat V, Mack WJ, Quinn JF, Yurko-Mauro K, Bailey-Hall E, Aisen PS, Chui HC, Schneider LS. The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer’s disease. Alzheimers Res Ther. 2016 Jun 30;8:25. PubMed.

K Rosenke et al. Plasmodium parasitemia associated with increased survival in Ebola virus-infected patients. Clinical Infectious Diseases, 2016; DOI: 10.1093/cid/ciw452.

Carlos Celis-Morales, et al Effect of personalized nutrition on health-related behaviour change: evidence from the Food4me European randomized controlled trial. International Journal of Epidemiology, 2016; dyw186 DOI: 10.1093/ije/dyw186

Henrik M. Roager, Lea B. S. Hansen, Martin I. Bahl, Henrik L. Frandsen, Vera Carvalho, Rikke J. Gøbel, Marlene D. Dalgaard, Damian R. Plichta, Morten H. Sparholt, Henrik Vestergaard, Torben Hansen, Thomas Sicheritz-Pontén, H. Bjørn Nielsen, Oluf Pedersen, Lotte Lauritzen, Mette Kristensen, Ramneek Gupta, Tine R. Licht. Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut. Nature Microbiology, 2016; 1: 16093 DOI: 10.1038/nmicrobiol.2016.93

IHCAN AUGUST references

NEWS

SACN vitamin D and health report, from

Public Health England

First published: 21 July 2016

Part of: SACN: reports and position statements and Obesity and healthy eating The Scientific Advisory Committee on Nutrition (SACN) recommendations on vitamin D: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/537616/SACN_Vitamin_D_and_Health_report.pdf

US statistics:

Nahin RL, Barnes PM, Stussman BJ. Expenditures on complementary health approaches: United States, 2012. (433KB PDF) National Health Statistics Reports. Hyattsville, MD: National Center for Health Statistics. 2016.

NEW RELEASES
ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies

Liana C. Del Gobbo et al. JAMA Intern Med. Published online June 27, 2016. doi:10.1001/jamainternmed.2016.2925

BEN BROWN

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4. Ragavan ND, Govind SK, Chye TT, Mahadeva S. Phenotypic variation in Blastocystis sp. ST3. Parasit Vectors. 2014 Aug 29;7:404.
5. Vargas-Sanchez GB, Romero-Valdovinos M, Ramirez-Guerrero C, et al. Blastocystis Isolates from Patients with Irritable Bowel Syndrome and from Asymptomatic Carriers Exhibit Similar Parasitological Loads, but Significantly Different Generation Times and Genetic Variability across Multiple Subtypes. PLoS One. 2015 Apr 29;10(4):e0124006.
6. Kuo HY, Chiang DH, Wang CC, et al. Clinical significance of Blastocystis hominis: experience from a medical center in northern Taiwan. J Microbiol Immunol Infect. 2008 Jun;41(3):222-6.
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8. Borody TJ, Warren EF, Wettstein A, et al. Eradication ofDientamoeba fragilis can resolve IBS-like symptoms. J Gastroenterol Hepatol.2002;17:A103.
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11. El Wakil SS. Evaluation of the in vitro effect of Nigella sativa aqueous extract on Blastocystis hominis isolates. J Egypt Soc Parasitol. 2007 Dec;37(3):801-13.
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13. Chen C, Tao C, Liu Y, et al. A Randomized Clinical Trial of Berberine Hydrochloride in Patients with Diarrhea-Predominant Irritable Bowel Syndrome. Phytother Res. 2015 Sep 24. doi: 10.1002/ptr.5475
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Further reading suggested by Dr Christen Rune Stensvold, PhD (http://www.blastocystis.net):

Pepper, J., & Rosenfeld, S. (2012). The emerging medical ecology of the human gut microbiome Trends in Ecology & Evolution, 27 (7), 381-384 DOI: 10.1016/j.tree.2012.03.002

Dethlefsen, L., & Relman, D. (2010). Colloquium Paper: Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation Proceedings of the National Academy of Sciences, 108 (Supplement_1), 4554-4561 DOI: 10.1073/pnas.1000087107

Stensvold, C., Christiansen, D., Olsen, K., & Nielsen, H. (2011). Blastocystis sp. Subtype 4 is Common in Danish Blastocystis-Positive Patients Presenting with Acute Diarrhea American Journal of Tropical Medicine and Hygiene, 84 (6), 883-885 DOI: 10.4269/ajtmh.2011.11-0005

Domínguez-Márquez, M., Guna, R., Muñoz, C., Gómez-Muñoz, M., & Borrás, R. (2009). High prevalence of subtype 4 among isolates of Blastocystis hominis from symptomatic patients of a health district of Valencia (Spain) Parasitology Research, 105 (4), 949-955 DOI: 10.1007/s00436-009-1485-y

Stensvold, C., (2012). Thinking Blastocystis Out Of The Box. Trends in Parasitology DOI: 10.1016/j.pt.2012.05.004

JOINTS and BONES
Originally published as “Biological and therapeutic effects of ortho-silicic acid and some ortho-silicic acid-releasing compounds: new perspectives for therapy”, Nutr Metab (Lond). 2013; 10: 2. Published online 2013 Jan 8. doi:  10.1186/1743-7075-10-2 as an Open Access article by BioMed Cantral.

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Genome Med. 2016 Apr 21;8(1):43. (doi: 10.1186/s13073-016-0299-7)

An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis. Chen J¹, Wright K², Davis JM², Jeraldo P³, Marietta EV⁴, Murray J⁴, Nelson H³, Matteson EL², Taneja V⁵.

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RESEARCH
Cospeciation of gut microbiota with hominids

Andrew H. Moeller et al. Science  22 Jul 2016: Vol. 353, Issue 6297, pp. 380-382
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Suzanna M. Zick, ND, MPH^1,2; Ananda Sen, PhD^1,3; Gwen K. Wyatt, PhD, RN⁴; Susan L. Murphy, PhD^5,6; J. Todd Arnedt, PhD^7,8,9; Richard E. Harris, PhD¹⁰

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NEWS

Evaluation of a functional medicine approach to treating fatigue, stress, and digestive issues in women. Susanne M. Cutshall,
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15. Toulis KA, Anastasilakis AD, Tzellos TG, Goulis DG, Kouvelas D. Selenium supplementation in the treatment of Hashimoto’s thyroiditis: a systematic review and a meta-analysis. Thyroid. 2010 Oct;20(10):1163-73.
16. Palinkas LA, Reedy KR, Smith M, Anghel M, Steel GD, Reeves D, Shurtleff D, Case HS, Van Do N, Reed HL. Psychoneuroendocrine effects of combined thyroxine and triiodothyronine versus tyrosine during prolonged Antarctic residence. Int J Circumpolar Health. 2007 Dec;66(5):401-17.
17. Felker P, Bunch R, Leung AM. Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism. Nutr Rev. 2016 Apr;74(4):248-58.
18. Sathyapalan T, Manuchehri AM, Thatcher NJ, Rigby AS, Chapman T, Kilpatrick ES, Atkin SL. The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: a randomized, double-blind, crossover study. J Clin Endocrinol Metab. 2011 May;96(5):1442-9.
19. Messina M, Redmond G. Effects of soy protein and soybean isoflavones on thyroid function in healthy adults and hypothyroid patients: a review of the relevant literature. Thyroid. 2006 Mar;16(3):249-58.
20. Peckham S, Lowery D, Spencer S. Are fluoride levels in drinking water associated with hypothyroidism prevalence in England? A large observational study of GP practice data and fluoride levels in drinking water. J Epidemiol Community Health. 2015 Jul;69(7):619-24.
21. Chandra AK, Goswami H, Sengupta P. Dietary calcium induced cytological and biochemical changes in thyroid. Environ Toxicol Pharmacol. 2012 Sep;34(2):454-65.
22. Wang N, Zhou Y, Fu C, Wang H, Huang P, Wang B, Su M, Jiang F, Fang H, Zhao Q, Chen Y, Jiang Q. Influence of Bisphenol A on Thyroid Volume and Structure Independent of Iodine in School Children. PLoS One. 2015 Oct 23;10(10):e0141248.
23. Pelletier C, Doucet E, Imbeault P, Tremblay A. Associations between weight loss-induced changes in plasma organochlorine concentrations, serum T(3) concentration, and resting metabolic rate. Toxicol Sci. 2002 May;67(1):46-51.
24. Di Matola T, Zeppa P, Gasperi M, Vitale M. Thyroid dysfunction following a kelp-containing marketed diet. BMJ Case Rep. 2014 Oct 29;2014.
25. Sategna-Guidetti C, et al. Prevalence of thyroid disorders in untreated adult celiac disease patients and effect of gluten withdrawal: an Italian multicenter study. Am J Gastroenterol. 2001 Mar;96(3):751-7.

PANEL: Antje Brüser, Angela Schulz, Sven Rothemund, Albert Ricken, Davide Calebiro, Gunnar Kleinau, Torsten Schöneberg. The Activation Mechanism of Glycoprotein Hormone Receptors with Implications in the Cause and Therapy of Endocrine Diseases. Journal of Biological Chemistry, 2016; 291 (2): 508 DOI: 10.1074/jbc.M115.701102

BRAIN HEALTH
Miguel’s key papers and suggestions for further reading

Bhullar, K. S. & Rupasinghe, H. P. (2013) Polyphenols: multipotent therapeutic agents in neurodegenerative diseases. Oxid Med Cell Longev, 2013pp. 891748.

Cascalheira, J. F., Goncalves, M., Barroso, M., Castro, R., Palmeira, M., Serpa, A., Dias-Cabral, A. C., Domingues, F. C. & Almeida, S. (2015) Association of the transcobalamin II gene 776C –> G polymorphism with Alzheimer’s type dementia: dependence on the 5, 10-methylenetetrahydrofolate reductase 1298A –> C polymorphism genotype. Ann Clin Biochem, 52(Pt 4) pp. 448-55.

Fowler, A. K., Hewetson, A., Agrawal, R. G., Dagda, M., Dagda, R., Moaddel, R., Balbo, S., Sanghvi, M., Chen, Y., Hogue, R. J., Bergeson, S. E., Henderson, G. I. & Kruman, Ii (2012) Alcohol-induced one-carbon metabolism impairment promotes dysfunction of DNA base excision repair in adult brain. J Biol Chem, 287(52) pp. 43533-42.

Iriti, M. & Varoni, E. M. (2015) Melatonin in Mediterranean diet, a new perspective. J Sci Food Agric, 95(12) pp. 2355-9.

Lopes Da Silva, S., Vellas, B., Elemans, S., Luchsinger, J., Kamphuis, P., Yaffe, K., Sijben, J., Groenendijk, M. & Stijnen, T. (2014) Plasma nutrient status of patients with Alzheimer’s disease: Systematic review and meta-analysis. Alzheimers Dement, 10(4) pp. 485-502.

Pallauf, K., Giller, K., Huebbe, P. & Rimbach, G. (2013) Nutrition and healthy ageing: calorie restriction or polyphenol-rich “MediterrAsian” diet? Oxid Med Cell Longev, 2013pp. 707421.

Pedret, A., Valls, R. M., Fernandez-Castillejo, S., Catalan, U., Romeu, M., Giralt, M., Lamuela-Raventos, R. M., Medina-Remon, A., Arija, V., Aranda, N., Espinel, A., Delgado, M. A. & Sola, R. (2012) Polyphenol-rich foods exhibit DNA antioxidative properties and protect the glutathione system in healthy subjects. Mol Nutr Food Res, 56(7) pp. 1025-33.

Rai, V. (2016) Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism and Alzheimer Disease Risk: a Meta-Analysis. Mol Neurobiol, pp.

Scoditti, E., Capurso, C., Capurso, A. & Massaro, M. (2014) Vascular effects of the Mediterranean diet-part II: role of omega-3 fatty acids and olive oil polyphenols. Vascul Pharmacol, 63(3) pp. 127-34.
Shen, L. & Ji, H. F. (2015) Associations between Homocysteine, Folic Acid, Vitamin B12 and Alzheimer’s Disease: Insights from Meta-Analyses. J Alzheimers Dis, 46(3) pp. 777-90.

Toledo, E., Salas-Salvado, J., Donat-Vargas, C., Buil-Cosiales, P., Estruch, R., Ros, E., Corella, D., Fito, M., Hu, F. B., Aros, F., Gomez-Gracia, E., Romaguera, D., Ortega-Calvo, M., Serra-Majem, L., Pinto, X., Schroder, H., Basora, J., Sorli, J. V., Bullo, M., Serra-Mir, M. & Martinez-Gonzalez, M. A. (2015) Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial. JAMA Intern Med, 175(11) pp. 1752-60.

Tuttolomondo, A., Casuccio, A., Butta, C., Pecoraro, R., Di Raimondo, D., Della Corte, V., Arnao, V., Clemente, G., Maida, C., Simonetta, I., Miceli, G., Lucifora, B., Cirrincione, A., Di Bona, D., Corpora, F., Maugeri, R., Iacopino, D. G. & Pinto, A. (2015) Mediterranean Diet in patients with acute ischemic stroke: Relationships between Mediterranean Diet score, diagnostic subtype, and stroke severity index. Atherosclerosis, 243(1) pp. 260-7.

RESEARCH

Daniel Brugger, Wilhelm M. Windisch. Subclinical zinc deficiency impairs pancreatic digestive enzyme activity and digestive capacity of weaned piglets. British Journal of Nutrition, 2016; 1 (doi: 10.1017/S0007114516002105).

Sci Rep. 2016 Jun 3;6:27010. doi: 10.1038/srep27010.
Paternal under-nutrition programs metabolic syndrome in offspring which can be reversed by antioxidant/vitamin food fortification in fathers.
McPherson NO1,2, Fullston T1, Kang WX1, Sandeman LY1, Corbett MA3, Owens JA1, Lane M1,4.

J Med Food. 2016 May 20. [Epub ahead of print] doi: 10.1089/jmf.2016.0030.
Inhibition of TNF-α, IL-1α, and IL-1β by Pretreatment of Human Monocyte-Derived Macrophages with Menaquinone-7 and Cell Activation with TLR Agonists In Vitro.
Pan MH, Maresz K5, Lee PS4, Wu JC4, Ho CT6, Popko J7,8, Mehta DS9, Stohs SJ10, Badmaev V.

Ramon Estruch, Miguel Angel Martínez-González, Dolores Corella, Jordi Salas-Salvadó, Montserrat Fitó, Gemma Chiva-Blanch, Miquel Fiol, Enrique Gómez-Gracia, Fernando Arós, José Lapetra, Lluis Serra-Majem, Xavier Pintó, Pilar Buil-Cosiales, José V Sorlí, Miguel A Muñoz, Josep Basora-Gallisá, Rosa María Lamuela-Raventós, Mercè Serra-Mir, Emilio Ros. Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial. The Lancet Diabetes & Endocrinology, 2016; DOI: 10.1016/S2213-8587(16)30085-7
Moran Yassour et al. Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability. Science Translational Medicine, 2016 DOI: 10.1126/scitranslmed.aad0917 .
Franziska Faber, Lisa Tran, Mariana X. Byndloss, Christopher A. Lopez, Eric M. Velazquez, Tobias Kerrinnes, Sean-Paul Nuccio, Tamding Wangdi, Oliver Fiehn, Renée M. Tsolis, Andreas J. Bäumler. Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion. Nature, 2016; DOI: 10.1038/nature18597 .
Catherine R. Marinac, Sandahl H. Nelson, Caitlin I. Breen, Sheri J. Hartman, Loki Natarajan, John P. Pierce, Shirley W. Flatt, Dorothy D. Sears, Ruth E. Patterson. Prolonged Nightly Fasting and Breast Cancer Prognosis. JAMA Oncology, 2016; DOI: 10.1001/jamaoncol.2016.0164.
Sara Vieira-Silva, Gwen Falony, Youssef Darzi, Gipsi Lima-Mendez, Roberto Garcia Yunta, Shujiro Okuda, Doris Vandeputte, Mireia Valles-Colomer, Falk Hildebrand, Samuel Chaffron, Jeroen Raes. Species–function relationships shape ecological properties of the human gut microbiome. Nature Microbiology, 2016; 16088 DOI: 10.1038/nmicrobiol.2016.88.
Lakshmi Krishnamoorthy, Joseph A Cotruvo, Jefferson Chan, Harini Kaluarachchi, Abigael Muchenditsi, Venkata S Pendyala, Shang Jia, Allegra T Aron, Cheri M Ackerman, Mark N Vander Wal, Timothy Guan, Lukas P Smaga, Samouil L Farhi, Elizabeth J New, Svetlana Lutsenko, Christopher J Chang. Copper regulates cyclic-AMP-dependent lipolysis. Nature Chemical Biology, 2016; DOI: 10.1038/nchembio.2098
Bredesen
Dale E. Bredesen, Edwin C. Amos3, Jonathan Canick4, Mary Ackerley5, Cyrus Raji6, Milan Fiala7, and Jamila Ahdidan, Aging 2016, 8 (6): online at http://www.impactaging.com/papers/v8/n6/full/100981.html.

Bredesen DE. Reversal of cognitive decline: A novel therapeutic program. Aging 2014; 6:707-17. Doi: 10.18632/aging.100690.

IHCAN June 2016 references

NEWS
Emily G Severance, Kristin L Gressitt, Catherine R Stallings, Emily Katsafanas, Lucy A Schweinfurth, Christina L Savage, Maria B Adamos, Kevin M Sweeney, Andrea E Origoni, Sunil Khushalani, F Markus Leweke, Faith B Dickerson, Robert H Yolken. Candida albicans exposures, sex specificity and cognitive deficits in schizophrenia and bipolar disorder. npj Schizophrenia, 2016; 2: 16018 DOI: 10.1038/npjschz.2016.18
Martin A Makary, Michael Daniel. Medical error—the third leading cause of death in the US. BMJ, 2016; i2139 DOI: 10.1136/bmj.i2139
Jacquelaine Bartlett, Irene M. Predazzi, Scott M. Williams, William S. Bush, Yeunjung Kim, Stephen Havas, Peter P. Toth, Sergio Fazio, Michael Miller. Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor? Circulation: Cardiovascular Quality and Outcomes, 2016; CIRCOUTCOMES.115.002436 DOI: 10.1161/CIRCOUTCOMES.115.002436
Nutrition. 2016 Feb 13. pii: S0899-9007(16)00075-7. doi: 10.1016/j.nut.2016.01.021. [Epub ahead of print]Is it gluten-free? Relationship between self-reported gluten-free diet adherence and knowledge of gluten content of foods.
Silvester JA1, Weiten D2, Graff LA3, Walker JR3, Duerksen DR4
(Nutrition 2016, doi: 10.1016/j.nut.2016.01.021.)

Katharine A. Rimes, Joanna Ashcroft, Lauren Bryan, Trudie Chalder. Emotional Suppression in Chronic Fatigue Syndrome: Experimental Study.. Health Psychology, 2016; DOI: 10.1037/hea0000341
Toni Ali-Sisto, Tommi Tolmunen, Elena Toffol, Heimo Viinamäki, Pekka Mäntyselkä, Minna Valkonen-Korhonen, Kirsi Honkalampi, Anu Ruusunen, Vidya Velagapudi, Soili M. Lehto. Purine metabolism is dysregulated in patients with major depressive disorder. Psychoneuroendocrinology, 2016; 70: 25 DOI: 10.1016/j.psyneuen.2016.04.017
Hilary P. Browne, Samuel C. Forster, Blessing O. Anonye, Nitin Kumar, B. Anne Neville, Mark D. Stares, David Goulding, Trevor D. Lawley. Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation. Nature, 2016; DOI: 10.1038/nature17645

BEN BROWN

1. Ginsburg GS, Willard HF. Genomic and personalized medicine: foundations and applications. Transl Res. 2009 Dec;154(6):277-87.
2. Minich DM, Bland JS. Personalized lifestyle medicine: relevance for nutrition and lifestyle recommendations. ScientificWorldJournal. 2013 Jun 26;2013:129841.
3. Fenech M, El-Sohemy A, Cahill L, et al. Nutrigenetics and nutrigenomics: viewpoints on the current status and applications in nutrition research and practice. J Nutrigenet Nutrigenomics. 2011;4(2):69-89.
4. Sykiotis GP, Kalliolias GD, Papavassiliou AG. Pharmacogenetic principles in the Hippocratic writings. J Clin Pharmacol. 2005 Nov;45(11):1218-20.
5. Jaiswal YS, Williams LL, A glimpse of Ayurveda e The forgotten history and principles of Indian traditional medicine, Journal of Traditional and Complementary Medicine (2016), http://dx.doi.org/10.1016/j.jtcme.2016.02.002
6. Gupta PD. Pharmacogenetics, pharmacogenomics and ayurgenomics for personalized medicine: a paradigm shift. Indian J Pharm Sci. 2015 Mar-Apr;77(2):135-41.
7. Prasher B, Gibson G, Mukerji M. Genomic insights into ayurvedic and western approaches to personalized medicine. J Genet. 2016 Mar;95(1):209-28.
8. Rotti H, Mallya S, Kabekkodu SP, et al. DNA methylation analysis of phenotype specific stratified Indian population. J Transl Med. 2015 May 8;13:151.
9. Govindaraj P, Nizamuddin S, Sharath A, et al. Genome-wide analysis correlates Ayurveda Prakriti. Sci Rep. 2015 Oct 29;5:15786.
10. Prasher B, Negi S, Aggarwal S, et al. Whole genome expression and biochemical correlates of extreme constitutional types defined in Ayurveda. J Transl Med. 2008 Sep 9;6:48.
11. Mahalle, N. P., Kulkarni, M. V., Pendse, N. M. & Naik, S. S. Association of constitutional type of Ayurveda with cardiovascular risk factors, inflammatory markers and insulin resistance. J. Ayurveda Integr. Med. 3, 150–157 (2012).
12. DuBroff R, Lad V, Murray-Krezan C. A Prospective Trial of Ayurveda for Coronary Heart Disease: A Pilot Study. Altern Ther Health Med. 2015 Sep-Oct;21(5):52-62.
13. Rasmussen LB, Mikkelsen K, Haugen M, et al. Treatment of fibromyalgia at the Maharishi Ayurveda Health Centre in Norway. A six-month follow-up study. Clin Exp Rheumatol. 2009 Sep-Oct;27(5 Suppl 56):S46-50.
14. Patel KB, Patel M, Mehta CS, Gupta S, Kessler CS. Ayurvedic management of ulcerative colitis–a non-randomized observational clinical study. Forsch Komplementmed. 2013;20(2):144-7.
15. Banerjee S, Debnath P, Debnath PK. Ayurnutrigenomics: Ayurveda-inspired personalized nutrition from inception to evidence. J Tradit Complement Med. 2015 Mar 24;5(4):228-33.

MIGUEL TORIBIO-MATEAS
Further reading – Part 1
1. Chow, H. M. & Herrup, K. (2015) Genomic integrity and the ageing brain. Nat Rev Neurosci, 16(11) pp. 672-84.
2. St Laurent, G., 3rd, Hammell, N. & Mccaffrey, T. A. (2010) A LINE-1 component to human aging: do LINE elements exact a longevity cost for evolutionary advantage? Mech Ageing Dev, 131(5) pp. 299-305.
3. Ames, B. N., Atamna, H. & Killilea, D. W. (2005) Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging. Mol Aspects Med, 26(4-5) pp. 363-78.
4. Hernandez-Aguilera, A., Rull, A., Rodriguez-Gallego, E., Riera-Borrull, M., Luciano-Mateo, F., Camps, J., Menendez, J. A. & Joven, J. (2013) Mitochondrial dysfunction: a basic mechanism in inflammation-related non-communicable diseases and therapeutic opportunities. Mediators Inflamm, 2013pp. 135698.
5. Meramat, A., Rajab, N. F., Shahar, S. & Sharif, R. (2015) Cognitive impairment, genomic instability and trace elements. J Nutr Health Aging, 19(1) pp. 48-57.

MARK HOUSTON – Mercury

1. Keating MH, Mahaffey KR, Schoemy R, Rice GE, Bullock R, et al. (1997) Mercury study report to Congress. Vol. I. Executive summary. EPA-452/R-97-003, Environmental Protection Agency, Washington, DC.
2. (2000) Committee on the Toxicological Effects of Methylmercury, Board on Environmental Studies and Toxicology, Commission on Life Sciences. Toxicological effects of methylmercury. National Research Council, Washington, DC.
3. Magos L (1997) Physiology and toxicology of mercury. Met Ions BiolSyst 34: 321-370.
4. Clarkson TW, Magos L, Myers GJ (2003) The toxicology of mercury-current exposures and clinical manifestations. N Engl J Med 349: 1731-1737.
5. Guallar E, Sanz-Gallardo MI, van’t Veer P, Bode P, Aro A, et al. (2002) Mercury, fish oils, and the risk of myocardial infarction.N Engl J Med 347: 1747-1754.
6. Weinhold B (2004) Environmental cardiology: getting to the heart of the matter.Environ Health Perspect 112: A880-887.
7. Bhatnagar A (2006) Environmental cardiology: studying mechanistic links between pollution and heart disease.Circ Res 99: 692-705.
8. (2012)CERCLA Priority List of Hazardous Substances.
9. Ahlqwist M, Bengtsson C, Lapidus L, Gergdahl IA, Schütz A (1999) Serum mercury concentration in relation to survival, symptoms, and diseases: results from the prospective population study of women in Gothenburg, Sweden.ActaOdontolScand 57: 168-174.
10. Bergdahl IA, Schütz A, Ahlqwist M, Bengtsson C, Lapidus L, et al. (1998) Methylmercury and inorganic mercury in serum–correlation to fish consumption and dental amalgam in a cohort of women born in 1922.Environ Res 77: 20-24.
11. Salonen JT, Seppänen K, Nyyssönen K, Korpela H, Kauhanen J, et al. (1995) Intake of mercury from fish, lipid peroxidation, and the risk of myocardial infarction and coronary, cardiovascular, and any death in eastern Finnish men.Circulation 91: 645-655.
12. Yoshizawa K, Rimm EB, Morris JS, Spate VL, Hsieh CC, et al. (2002) Mercury and the risk of coronary heart disease in men.N Engl J Med 347: 1755-1760.
13. Chmielnicka J, Bem EM, Kaszubski P (1983) Organ and subcellular distribution of cadmium in rats exposed to cadmium, mercury, and selenium. Environ Res 31: 266-272.
14. Komsta-Szumska E, Chmielnicka J (1983) Effect of zinc, cadmium or copper on mercury distribution in rat tissues.ToxicolLett 17: 349-354.
15. International Programme on Chemical Safety (IPCS) (1990)Methylmercury. Environmental Health Criteria 101. Geneva: World Health Organization, USA.
16. Salonen JT, Seppänen K, Lakka TA, Salonen R, Kaplan GA (2000) Mercury accumulation and accelerated progression of carotid atherosclerosis: a population-based prospective 4-year follow-up study in men in eastern Finland.Atherosclerosis 148: 265-273.
17. Skoczyska A, Poreba R, Steinmentz-Beck A, Martynowicz H, Affelska-Jercha A, et al. (2009) The dependence between urinary mercury concentration and carotid arterial intima-media thickness in workers occupationally exposed to mercury vapour. Int J Occup Med Environ Health 22: 135-142.
18. Parízek J, Ostádalová I (1967) The protective effect of small amounts of selenite in sublimate intoxication.Experientia 23: 142-143.
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21. Stoewsand GS, Bache CA, Lisk DJ (1974) Dietary selenium protection of methylmercury intoxication of Japanese quail.Bull Environ ContamToxicol 11: 152-156.
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23. Singhal RK, Anderson ME, Meister A (1987) Glutathione, a first line of defense against cadmium toxicity. FASEB J 1: 220-223.
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25. Lund BO, Miller DM, Woods JS (1993) Studies on Hg(II)-induced H2O2 formation and oxidative stress in vivo and in vitro in rat kidney mitochondria.BiochemPharmacol 45: 2017-2024.
26. Shenker BJ, Guo TL, Shapiro IM (1998) Low-level methylmercury exposure causes human T-cells to undergo apoptosis: evidence of mitochondrial dysfunction.Environ Res 77: 149-159.

27. Jansson G, Harms-Ringdahl M (1993) Stimulating effects of mercuric- and silver ions on the superoxide anion production in human polymorphonuclear leukocytes.Free Radic Res Commun 18: 87-98.

28. Clarkson TW (1997) The toxicology of mercury.Crit Rev Clin Lab Sci 34: 369-403.

29. Insug O, Datar S, Koch CJ, Shapiro IM, Shenker BJ (1997) Mercuric compounds inhibit human monocyte function by inducing apoptosis: evidence for formation of reactive oxygen species, development of mitochondrial membrane permeability transition and loss of reductive reserve. Toxicology 124:211-224.

30. Wiggers GA, Pecanha FM, Briones AM, Perez-Giron JV, Miguel M, et al. (2008) Low mercury concentrations cause oxidative stress and endothelial dysfunction in conductance and resistance arteries. Am J Physiol Heart CircPhysiol 295: 1033-1043.

31. Kobal AB, Horvat M, Prezelj M, Briski AS, Krsnik M, et al. (2004) The impact of long-term past exposure to elemental mercury on antioxidative capacity and lipid peroxidation in mercury miners.J Trace Elem Med Biol 17: 261-274.

32. Park ST, Lim KT, Chung YT, Kim SU (1996) Methylmercury-induced neurotoxicity in cerebral neuron culture is blocked by antioxidants and NMDA receptor antagonists.Neurotoxicology 17: 37-45.

33. Miller DM, Lund BO, Woods JS (1991) Reactivity of Hg(II) with superoxide: evidence for the catalytic dismutation of superoxide by Hg(II).J BiochemToxicol 6: 293-298.

34. Naganuma A, Koyama Y, Imura N (1980) Behavior of methylmercury in mammalian erythrocytes.ToxicolApplPharmacol 54: 405-410.

35. Cuvin-Aralar ML, Furness RW (1991) Mercury and selenium interaction: a review.Ecotoxicol Environ Saf 21: 348-364.

36. Rungby J, Ernst E (1992) Experimentally induced lipid peroxidation after exposure to chromium, mercury or silver: interactions with carbon tetrachloride.PharmacolToxicol 70: 205-207.

37. Lin TH, Huang YL, Huang SF (1996) Lipid peroxidation in liver of rats administrated with methyl mercuric chloride.Biol Trace Elem Res 54: 33-41.

38. Wierzbicki R, Prazanowski M, Michalska M, Krajewska U, Mielicki WP (2002) Disorders in blood coagulation in humans occupationally exposed to mercuric vapors. J Trace Elem Exp Med 15:21-29.

39. Kishimoto T, Oguri T, Abe M, Kajitani H, Tada M (1995) Inhibitory effect of methylmercury on migration and tube formation by cultured human vascular endothelial cells.Arch Toxicol 69: 357-361.

40. Lu KP, Zhao SH, Wang DS (1990) The stimulatory effect of heavy metal cations on proliferation of aortic smooth muscle cells.Sci China B 33: 303-310.

41. Gonzalvo MC, Gil F, Hernández AF, Villanueva E, Pla A (1997) Inhibition of paraoxonase activity in human liver microsomes by exposure to EDTA, metals and mercurials.ChemBiol Interact 105: 169-179.

42. Salonen JT, Malin R, Tuomainen TP, Nyyssönen K, Lakka TA, et al. (1999) Polymorphism in high density lipoprotein paraoxonase gene and risk of acute myocardial infarction in men: prospective nested case-control study.BMJ 319: 487-489.

43. Boffetta P, Sällsten G, Garcia-Gómez M, Pompe-Kirn V, Zaridze D, et al. (2001) Mortality from cardiovascular diseases and exposure to inorganic mercury.Occup Environ Med 58: 461-466.

44. Torres AD, Rai AN, Hardiek ML (2000) Mercury intoxication and arterial hypertension: report of two patients and review of the literature.Pediatrics 105: E34.

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47. Rissanen T, Voutilainen S, Nyyssonen K, Lakka TA, Salonen JT (2000) Fish oil-derived fatty acids, docosahexaenoic acid and docosapentaenoic acid, and the risk of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study. Circulation 102:2677-2679.

48. Virtanen JK, Voutilainen S, Rissanen TH, Mursu J, Tuomainen TP, et al. (2005) Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland.ArteriosclerThrombVascBiol 25: 228-233.

49. Kobal AB, Flisar Z, Miklavcic V, Dizdarević T, Sesek-Briski A (2000) Renal function in miners intermittently exposed to elemental mercury vapour.ArhHigRadaToksikol 51: 369-380.

50. Connor WE (2000) Importance of n-3 fatty acids in health and disease.Am J ClinNutr 71: 171S-5S.

51. Burr ML, Fehily AM, Gilbert JF, Rogers S, Holliday RM, et al. (1989) Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART).Lancet 2: 757-761.

52. (1999) GISSI-Prevenzione Investigators (GruppoItaliano per lo Studio dellaSopravvivenzanell’Infartomiocardico). Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 354:447-455.

53. Marckmann P, Grønbaek M (1999) Fish consumption and coronary heart disease mortality. A systematic review of prospective cohort studies.Eur J ClinNutr 53: 585-590.

54. MacIntosh DL, Williams PL, Hunter DJ, Sampson LA, Morris SC, et al. (1997) Evaluation of a food frequency questionnaire-food composition approach for estimating dietary intake of inorganic arsenic and methylmercury. Cancer Epidemiol Biomarkers Prev 6:1043-1050.

55. Garland M, Morris JS, Rosner BA, Stampfer MJ, Spate VL, et al. (1993) Toenail trace element levels as biomarkers: reproducibility over a 6-year period.Cancer Epidemiol Biomarkers Prev 2: 493-497.

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57. Mazerik JN, Hagele T, Sherwani S, Ciapala V, Butler S, et al. (2007) Phospholipase A2 activation regulates cytotoxicity of methylmercury in vascular endothelial cells.Int J Toxicol 26: 553-569.

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EFAs REVIEW
O. van de Rest, Y. Wang, L. L. Barnes, C. Tangney, D. A. Bennett, M. C. Morris. APOE 4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline. Neurology, 2016; DOI: 10.1212/WNL.0000000000002719
Jerome Sarris, Jenifer Murphy, David Mischoulon, George I. Papakostas, Maurizio Fava, Michael Berk, Chee H. Ng. Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses. American Journal of Psychiatry, 2016; appi.ajp.2016.1 DOI: 10.1176/appi.ajp.2016.15091228

Adrian Raine, Rose A. Cheney, Ringo Ho, Jill Portnoy, Jianghong Liu, Liana Soyfer, Joseph Hibbeln, Therese S. Richmond. Nutritional supplementation to reduce child aggression: a randomized, stratified, single-blind, factorial trial. Journal of Child Psychology and Psychiatry, 2016; DOI: 10.1111/jcpp.12565
Adrian Raine, Jill Portnoy, Jianghong Liu, Tashneem Mahoomed, Joseph R. Hibbeln. Reduction in behavior problems with omega-3 supplementation in children aged 8-16 years: a randomized, double-blind, placebo-controlled, stratified, parallel-group trial. Journal of Child Psychology and Psychiatry, 2015; 56 (5): 509 DOI: 10.1111/jcpp.12314

Qingying Meng, Zhe Ying, Emily Noble, Yuqi Zhao, Rahul Agrawal, Andrew Mikhail, Yumei Zhuang, Ethika Tyagi, Qing Zhang, Jae-Hyung Lee, Marco Morselli, Luz Orozco, Weilong Guo, Tina M. Kilts, Jun Zhu, Bin Zhang, Matteo Pellegrini, Xinshu Xiao, Marian F. Young, Fernando Gomez-Pinilla, Xia Yang. Systems Nutrigenomics Reveals Brain Gene Networks Linking Metabolic and Brain Disorders. EBioMedicine, 2016; DOI: 10.1016/j.ebiom.2016.04.008
RESEARCH UPDATE
Nathan F. Johnson, Brian T. Gold, Alison L. Bailey, Jody L. Clasey, Jonathan G. Hakun, Matthew White, Doug E. Long, David K. Powell. Cardiorespiratory fitness modifies the relationship between myocardial function and cerebral blood flow in older adults. NeuroImage, 2016; 131: 126 DOI: 10.1016/j.neuroimage.2015.05.063
Vittori Gouveia Luciana de Almeida, Cardoso Carolina Alves, de Oliveira Glaucia Maria Moraes, Rosa Glorimar, and Moreira Annie Seixas Bello. Journal of Medicinal Food. April 2016, 19(4): 337-345. doi:10.1089/jmf.2015.0075. Published in Volume: 19 Issue 4: April 13, 2016

David K. Cole, Anna M. Bulek, Garry Dolton, Andrea J. Schauenberg, Barbara Szomolay, William Rittase, Andrew Trimby, Prithiviraj Jothikumar, Anna Fuller, Ania Skowera, Jamie Rossjohn, Cheng Zhu, John J. Miles, Mark Peakman, Linda Wooldridge, Pierre J. Rizkallah, Andrew K. Sewell. Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. Journal of Clinical Investigation, 2016; DOI: 10.1172/JCI85679.
Robert I. Richards, Sarah A. Robertson, Louise V. O’Keefe, Dani Fornarino, Andrew Scott, Michael Lardelli, Bernhard T. Baune. The Enemy within: Innate Surveillance-Mediated Cell Death, the Common Mechanism of Neurodegenerative Disease. Frontiers in Neuroscience, 2016; 10 DOI: 10.3389/fnins.2016.00193
G. Hagen, T. Wisløff, I. S. Kristiansen. The predicted lifetime costs and health consequences of calcium and vitamin D supplementation for fracture prevention—the impact of cardiovascular effects. Osteoporosis International, 2016; 27 (6): 2089 DOI: 10.1007/s00198-016-3495-9
Mingzhan Xue, Martin O Weickert, Sheharyar Qureshi, Ngianga-Bakwin Kandala, Attia Anwar, Molly Waldron, Alaa Shafie, David Messenger, Mark Fowler, Gail Jenkins, Naila Rabbani, Paul J. Thornalley. Improved glycemic control and vascular function in overweight and obese subjects by glyoxalase 1 inducer formulation. Diabetes, 2016; db160153 DOI: 10.2337/db16-0153
Julia K. Goodrich, Emily R. Davenport, Michelle Beaumont, Matthew A. Jackson, Rob Knight, Carole Ober, Tim D. Spector, Jordana T. Bell, Andrew G. Clark, Ruth E. Ley. Genetic Determinants of the Gut Microbiome in UK Twins. Cell Host & Microbe, 2016; 19 (5): 731 DOI: 10.1016/j.chom.2016.04.017

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ALZHEIMER’S 1,2. Prince MA, Emiliano; Guerchet, Maëlenn; Prina, Matthew. 2014; World Alzheimer Report 2014 United Kingdom: Alzheimer’s Disease International.

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ME/CFS * #MEAction petition http://my.meaction.net/petitions/pace-trial-needs-review-now * The PACE Lancet paper http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)60096-2/fulltext * Open letter to The Lancet from 42 scientists and doctors http://www.virology.ws/2016/02/10/open-letter-lancet-again/ * Dr David Tuller’s article on the PACE trial http://www.virology.ws/2015/10/21/trial-by-error-i/

BEN BROWN

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ALLERGIES and INTOLERANCES Perkin MR, Logan K, et al. Randomized trial of the early introduction of allergenic foods in breastfed infants. New England Journal of Medicine, 2016 DOI 10.1056/NEJMoa1514210 [Epub ahead of print] Jung-Hwan Kim, Eun-Ji Jeun, Chun-Pyo Hong, Seong-Hoon Kim, Min Seong Jang, Eun-Jung Lee, Sook Jin Moon, Chang Ho Yun, Sin-Hyeog Im, Seok-Geun Jeong, Beom-Young Park, Kyong-Tai Kim, Ju-Young Seoh, Yoon-Keun Kim, Sung-Jong Oh, Jun-Sang Ham, Bo-Gie Yang, Myoung Ho Jang. Extracellular vesicle–derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression. Journal of Allergy and Clinical Immunology, 2016; 137 (2): 507 DOI: 10.1016/j.jaci.2015.08.016 Roberto Berni Canani, Naseer Sangwan, Andrew T Stefka, Rita Nocerino, Lorella Paparo, Rosita Aitoro, Antonio Calignano, Aly A Khan, Jack A Gilbert, Cathryn R Nagler. Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants. The ISME Journal, 2015; DOI: 10.1038/ismej.2015.151

Matthieu Deschamps, Guillaume Laval, Maud Fagny, Yuval Itan, Laurent Abel, Jean-Laurent Casanova, Etienne Patin, Lluis Quintana-Murci. Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes. The American Journal of Human Genetics, 2016; 98 (1): 5 DOI: 10.1016/j.ajhg.2015.11.014 Michael Dannemann, Aida M. Andrés, Janet Kelso. Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors. The American Journal of Human Genetics, 2016; 98 (1): 22 DOI: 10.1016/j.ajhg.2015.11.015 Tabea Brick, Yvonne Schober, Christian Böcking, Juha Pekkanen, Jon Genuneit, Georg Loss, Jean-Charles Dalphin, Josef Riedler, Roger Lauener, Wolfgang Andreas Nockher, Harald Renz, Outi Vaarala, Charlotte Braun-Fahrländer, Erika von Mutius, Markus Johannes Ege, Petra Ina Pfefferle. ω-3 fatty acids contribute to the asthma-protective effect of unprocessed cow’s milk. Journal of Allergy and Clinical Immunology, 2016; DOI: 10.1016/j.jaci.2015.10.042 RESEARCH YihQ is a sulfoquinovosidase that cleaves sulfoquinovosyl diacylglyceride sulfolipids Gaetano Speciale, Yi Jin, Gideon J Davies, Spencer J Williams & Ethan D Goddard-Borger Nature Chemical Biology 2016, 12, 215–217. doi:10.1038/nchembio.2023. Witawas Handee, Xiaobo Li, Kevin W. Hall, Xiexiong Deng, Pan Li, Christoph Benning, Barry L. Williams, Min-Hao Kuo. An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast. PLOS Genetics, 2016; 12 (2): e1005878 DOI: 10.1371/journal.pgen.1005878 Loucks, Eric B.; Gilman, Stephen E.; Britton, Willoughby B.; Gutman, Roee; Eaton, Charles B.; Buka, Stephen L. Associations of Mindfulness with Glucose Regulation and Diabetes. American Journal of Health Behavior, February 2016 DOI: 10.5993/AJHB.40.2.11 Samuel E. Marsh, Edsel M. Abud, Anita Lakatos, Alborz Karimzadeh, Stephen T. Yeung, Hayk Davtyan, Gianna M. Fote, Lydia Lau, Jason G. Weinger, Thomas E. Lane, Matthew A. Inlay, Wayne W. Poon, Mathew Blurton-Jones. The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function. Proceedings of the National Academy of Sciences, 2016; 201525466 DOI: 10.1073/pnas.1525466113 Sean M. Grimmond et al. Genomic analyses identify molecular subtypes of pancreatic cancer. Nature, 2016; DOI: 10.1038/nature16965 Influence of Obesity on Breast Density Reduction by Omega-3 Fatty Acids: Evidence from a Randomized Clinical Trial. Sandhu N, Schetter SE, Liao J, Hartman TJ, Richie JP, McGinley J, Thompson HJ, Prokopczyk B, DuBrock C, Signori C, Hamilton C, Calcagnotto A, Trushin N, Aliaga C, Demers LM, El-Bayoumy K, Manni A. Cancer Prev Res (Phila). 2015 Dec 29. [Epub ahead of print] Aubrey J Cunnington, Kathleen Sim, Aniko Deierl, J Simon Kroll, Eimear Brannigan, Jonathan Darby. “Vaginal seeding” of infants born by caesarean section. BMJ, 2016; i227 DOI: 10.1136/bmj.i227 Molly K. Gibson, Bin Wang, Sara Ahmadi, Carey-Ann D. Burnham, Phillip I. Tarr, Barbara B. Warner, Gautam Dantas. Developmental dynamics of the preterm infant gut microbiota and antibiotic resistome. Nature Microbiology, 2016; 16024 DOI: 10.1038/nmicrobiol.2016.24

NEWS Jorge Vas, Koldo Santos-Rey, Reyes Navarro-Pablo, Manuela Modesto, Inmaculada Aguilar, M Ángeles Campos, José Francisco Aguilar-Velasco, Milagrosa Romero, Patricia Párraga, Vanesa Hervás, Olalla Santamaría, Carmen Márquez-Zurita, Francisco Rivas-Ruiz. Acupuncture for fibromyalgia in primary care: a randomised controlled trial. Acupuncture in Medicine, 2016; acupmed-2015-010950 DOI: 10.1136/acupmed-2015-010950.
Ferric C. Fang, Anthony Bowen and Arturo Casadevall. NIH Peer Review Percentile Scores are Poorly Predictive of Grant Productivity. eLife, 2016, DOI: http://dx.doi.org/10.7554/eLife.13323.

Sung Ryeol Park, Ashootosh Tripathi, Jianfeng Wu, Pamela J. Schultz, Isaiah Yim, Thomas J. McQuade, Fengan Yu, Carl-Johan Arevang, Abraham Y. Mensah, Giselle Tamayo-Castillo, Chuanwu Xi, David H. Sherman. Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway. Nature Communications, 2016; 7: 10710 DOI: 10.1038/ncomms10710. Charbonneau et al. Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition. Cell, 2016 DOI: 10.1016/j.cell.2016.01.024. L. Claxton, M. Taylor, E. Kay. Oral health promotion: the economic benefits to the NHS of increased use of sugarfree gum in the UK. BDJ, 2016; 220 (3): 121 DOI: 10.1038/sj.bdj.2016.94.

“Adding fluoride to water supply may have no benefit, say experts”. Haroon Siddique. The Guardian, Friday 25 December 2015: http://www.theguardian.com/society/2015/dec/25/fluoride-water-supply-benefit-unproved-tooth-decay.

M. Schwarzer, K. Makki, G. Storelli, I. Machuca-Gayet, D. Srutkova, P. Hermanova, M. E. Martino, S. Balmand, T. Hudcovic, A. Heddi, J. Rieusset, H. Kozakova, H. Vidal, F. Leulier. Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition. Science, 2016; 351 (6275): 854 DOI: 10.1126/science.aad8588. Associated references: Lactobacillus plantarum promotes Drosophila systemic growth by modulating hormonal signals through TOR-dependent nutrient sensing, Gilles Storelli, Arnaud Defaye, Berra Erkosar, Pascal Hols, Julien Royet, François Leulier, Cell Metabolism (2011) 14(3):403-414; and Pathogen Virulence Impedes Mutualist-Mediated Enhancement of Host Juvenile Growth via Inhibition of Protein Digestion. Berra Erkosar, Gilles Storelli, Mélanie Mitchell, Loan Bozonnet, Noémie Bozonnet, François Leulier. Cell Host and Microbe (2015) 18(4):445-55. Ana Isabel Ribeiro, Elias Teixeira Krainski, Marilia Sá Carvalho, Maria de Fátima de Pina. Where do people live longer and shorter lives? An ecological study of old-age survival across 4404 small areas from 18 European countries. Journal of Epidemiology and Community Health, 2016; jech-2015-206827 DOI: 10.1136/jech-2015-206827 . Cynthia Owsley, Gerald McGwin, Mark E. Clark, Gregory R. Jackson, Michael A. Callahan, Lanning B. Kline, C. Douglas Witherspoon, Christine A. Curcio. Delayed Rod-Mediated Dark Adaptation Is a Functional Biomarker for Incident Early Age-Related Macular Degeneration. Ophthalmology, 2016; 123 (2): 344 DOI: 10.1016/j.ophtha.2015.09.041. Line Pedersen et al. Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution. Cell Metabolism, February 2016 DOI: 10.1016/j.cmet.2016.01.011 Anil K. Singh, Sadiq Umar, Sharayah Riegsecker, Mukesh Chourasia, Salahuddin Ahmed. Regulation of Transforming Growth Factor β-Activated Kinase Activation by Epigallocatechin-3-Gallate in Rheumatoid Arthritis Synovial Fibroblasts: Suppression of K63-Linked Autoubiquitination of Tumor Necrosis Factor Receptor-Associated Factor 6. Arthritis & Rheumatology, 2016; 68 (2): 347 DOI: 10.1002/art.39447

GUT HEALTH and PROBIOTICS Julie Urban, Daniel J. Fergus, Amy M. Savage, Megan Ehlers, Holly L. Menninger, Robert R. Dunn, Julie E. Horvath. The effect of habitual and experimental antiperspirant and deodorant product use on the armpit microbiome. PeerJ, 2016; 4: e1605 DOI: 10.7717/peerj.1605 Shuichi Tonomura, Masafumi Ihara, Tomohiro Kawano, Tomotaka Tanaka, Yoshinori Okuno, Satoshi Saito, Robert P. Friedland, Nagato Kuriyama, Ryota Nomura, Yoshiyuki Watanabe, Kazuhiko Nakano, Kazunori Toyoda, Kazuyuki Nagatsuka. Intracerebral hemorrhage and deep microbleeds associated with cnm-positive Streptococcus mutans; a hospital cohort study. Scientific Reports, 2016; 6: 20074 DOI: 10.1038/srep20074 Hongjie Li, Yanyan Qi, Heinrich Jasper. Preventing Age-Related Decline of Gut Compartmentalization Limits Microbiota Dysbiosis and Extends Lifespan. Cell Host & Microbe, 2016; 19 (2): 240 DOI: 10.1016/j.chom.2016.01.008 Vinegar Treatment Prevents the Development of Murine Experimental Colitis via Inhibition of Inflammation and Apoptosis Fengge Shen†, Jiaxuan Feng§, Xinhui Wang†, Zhimin Qi†, Xiaochen Shi†, Yanan An†, Qiaoli Zhang†, Chao Wang†, Mingyuan Liu†#, Bo Liu*†, and Lu Yu*† J. Agric. Food Chem., 2016, 64 (5), pp 1111–1121, DOI: 10.1021/acs.jafc.5b05415

FUNCTIONAL MEDICINE – BEN BROWN

1. Costenbader KH, et al. Genes, epigenetic regulation and environmental factors: which is the most relevant in developing autoimmune diseases? Autoimmun Rev. 2012 Jun;11(8):604-9. 2. Ashan H et al. Oxygen free radicals and systemic autoimmunity. Clin Exp Immunol. 2003 Mar;131(3):398-404. 3. Kurien BT, Scofield RH. Autoimmunity and oxidatively modified autoantigens. Autoimmun Rev. 2008 Jul;7(7):567-73. 4. Perl A. Oxidative stress in the pathology and treatment of systemic lupus erythematosus. Nat Rev Rheumatol. 2013 Nov;9(11):674-86. 5. Wang G, Pierangeli SS, Papalardo E, Ansari GA, Khan MF. Markers of oxidative and nitrosative stress in systemic lupus erythematosus: correlation with disease activity. Arthritis Rheum. 2010 Jul;62(7):2064-72. 6. Ortona E, Margutti P, Matarrese P, Franconi F, Malorni W. Redox state, cell death and autoimmune diseases: a gender perspective. Autoimmun Rev. 2008 Jul;7(7):579-84. 7. Costenbader KH, Kang JH, Karlson EW. Antioxidant intake and risks of rheumatoid arthritis and systemic lupus erythematosus in women. Am J Epidemiol. 2010;172:205–216. 8. Tam LS, et al. Effects of vitamins C and E on oxidative stress markers and endothelial function in patients with systemic lupus erythematosus: A double-blind, placebo-controlled pilot study. J Rheumatol 2005;32:275–282. 9. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev. 2012 Mar 14;3:CD007176. 10. Harris C, Hansen JM. Oxidative stress, thiols, and redox profiles. Methods Mol Biol. 2012;889:325-46. 11. Perricone C, De Carolis C, Perricone R. Glutathione: a key player in autoimmunity. Autoimmun Rev. 2009 Jul;8(8):697-701. 12. Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr. 2015 Mar;54(2):251-63. 13. Allen J, Bradley RD. Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. J Altern Complement Med. 2011 Sep;17(9):827-33. 14. Lai ZW, Hanczko R, Bonilla E, et al. N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2012 Sep;64(9):2937-46. 15. Lai Z-W, Hanczko R, Bonilla E, et al. N-acetylcysteine reduces disease activity by blocking mTOR in T cells of lupus patients. Arthritis and Rheumatism. 2012;64:2937–2946. 16. Doherty E, Oaks Z, Perl A. Increased mitochondrial electron transport chain activity at complex I is regulated by N-acetylcysteine in lymphocytes of patients with systemic lupus erythematosus. Antioxid Redox Signal. 2014 Jul 1;21(1):56-65. 17. Perl A, Hanczko R, Lai ZW, Oaks Z, Kelly R, Borsuk R, Asara JM, Phillips PE. Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin. Metabolomics. 2015;11(5):1157-1174. 18. Li M, Gao W, Ma J, Zhu Y, Li X. Early-stage lupus nephritis treated with N-acetylcysteine: A report of two cases. Exp Ther Med. 2015 Aug;10(2):689-692. Epub 2015 May 21. 19. Khalili M, Azimi A, Izadi V, et al. Does lipoic acid consumption affect the cytokine profile in multiple sclerosis patients: a double-blind, placebo-controlled, randomized clinical trial. Neuroimmunomodulation. 2014;21(6):291-6. 20. Chandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res. 2012 Nov;26(11):1719-25. 21. Samsami-Kor M, Daryani NE, Asl PR, Hekmatdoost A. Anti-Inflammatory Effects of Resveratrol in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo controlled Pilot Study. Arch Med Res. 2015 May;46(4):280-5.

AGEING Deirdre A. Robertson, Rose Anne Kenny. Negative perceptions of ageing modify the association between frailty and cognitive function in older adults. Personality and Individual Differences, 2015; DOI: 10.1016/j.paid.2015.12.010

NUTRIGENOMICS – ANNE PEMBERTON 1. Klinghardt, D. (2013) kryptopyrroluria (Pyroluria) – Lyme Induced Autism. https://www.youtube.com/watch?v=THZhANfFnyY

2. Banerjee R, Zou CG (January 2005). “Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein”. Archives of Biochemistry and Biophysics 433 (1): 144–56. doi:10.1016/j.abb.2004.08.037. PMID 15581573.

3. http://mthfr.net/forums/topic/sulphur-sensitivity/

4. Dahlhoff C, Desmarchelier C, Sailer M, Fürst RW, Haag A, et al. (2013) Hepatic Methionine Homeostasis Is Conserved in C57BL/6N Mice on High-Fat Diet Despite Major Changes in Hepatic One-Carbon Metabolism. PLoS ONE 8(3): e57387. doi: 10.1371/journal.pone.0057387

NEWSGenotype, B-vitamin status, and androgens affect space flight–induced ophthalmic changes. January 2016 The FASEB Journal vol. 30 no. 1 141-148. Sara R. Zwart* et al.

doi: 10.1096/fj.15-278457.

NEWS – cancer

Vinay Prasad, Jeanne Lenzer, David H Newman. Why cancer screening has never been shown to “save lives”—and what we can do about it. BMJ, 2016; h6080 DOI: 10.1136/bmj.h6080

Gerd Gigerenzer. Full disclosure about cancer screening. BMJ, 2016; h6967 DOI: 10.1136/bmj.h6967

Substantial contribution of extrinsic risk factors to cancer development

Song Wu, Scott Powers, Wei Zhu & Yusuf A. Hannun.

Nature 529, 43–47, (07 January 2016)

doi:10.1038/nature16166).

Change the cancer conversation. The ‘war on cancer’ has run off course. Efforts must refocus on the best interests of patients, says Colin Macilwain.

01 April 2015: http://www.nature.com/news/change-the-cancer-conversation-1.17236. Nature 520, 7 (02 April 2015), doi:10.1038/520007a.

Lancet Oncology. Volume 16, No. 13, p1324–1334, October 2015

Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial

Dr Christophe Le Tourneau, MD ert al. DOI: http://dx.doi.org/10.1016/S1470-2045(15)00188-6.

Five Years of Cancer Drug Approvals, Innovation, Efficacy, and Costs

Sham Mailankody, MB BS1; Vinay Prasad, MD, MPH1

JAMA Oncol. 2015;1(4):539-540. doi:10.1001/jamaoncol.2015.0373.

BEN BROWN

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Leone V, Chang EB, Devkota S. Diet, microbes, and host genetics: the perfect storm in inflammatory bowel diseases. J Gastroenterol. 2013 Mar;48(3):315-21. Free full-text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698420.
Nickerson KP, Chanin R, McDonald C. Deregulation of intestinal anti-microbial defense by the dietary additive, maltodextrin. Gut Microbes. 2015;6(1):78-83.
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Nickerson KP, McDonald C. Crohn’s disease-associated adherent-invasive Escherichia coli adhesion is enhanced by exposure to the ubiquitous dietary polysaccharide maltodextrin. PLoS One. 2012;7(12):e52132.
HAAS SV, HAAS MP. The treatment of celiac disease with the specific carbohydrate diet; report on 191 additional cases. Am J Gastroenterol. 1955 Apr;23(4):344-60.
Gottschall E. Breaking the Vicious Cycle: Intestinal Health Through Diet. Baltimore, Canada: Kirkton Press; 1987. http://www.breakingtheviciouscycle.info/home
Walters SS et al. Analysis of gut microbiome and diet modification in patients with Crohn’s disease. SOJ Microbiol Infect Dis 2014, 2 (3):1–13. Free full-text online: http://www.symbiosisonlinepublishing.com/microbiology-infectiousdiseases/microbiology-infectiousdiseases22.php.
Kakodkar S, Farooqui AJ, Mikolaitis SL, Mutlu EA. The Specific Carbohydrate Diet for Inflammatory Bowel Disease: A Case Series. J Acad Nutr Diet. 2015 Aug;115(8):1226-32.
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Suskind DL, Wahbeh G, Gregory N, Vendettuoli H, Christie D. Nutritional therapy in pediatric Crohn disease: the specific carbohydrate diet. J Pediatr Gastroenterol Nutr. 2014 Jan;58(1):87-91.
Khandalavala BN, Nirmalraj MC. Resolution of Severe Ulcerative Colitis with the Specific Carbohydrate Diet. Case Rep Gastroenterol. 2015 Aug 7;9(2):291-5.
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Shepherd SJ, Lomer MC, Gibson PR. Short-chain carbohydrates and functional gastrointestinal disorders. Am J Gastroenterol. 2013 May;108(5):707-17.
Gearry RB, Irving PM, Barrett JS, Nathan DM, Shepherd SJ, Gibson PR. Reduction of dietary poorly absorbed short-chain carbohydrates (FODMAPs) improves abdominal symptoms in patients with inflammatory bowel disease-a pilot study. J Crohns Colitis. 2009 Feb;3(1):8-14.
Nucera G, Gabrielli M, Lupascu A, Lauritano EC, Santoliquido A, Cremonini F, Cammarota G, Tondi P, Pola P, Gasbarrini G, Gasbarrini A. Abnormal breath tests to lactose, fructose and sorbitol in irritable bowel syndrome may be explained by small intestinal bacterial overgrowth. Aliment Pharmacol Ther. 2005 Jun 1;21(11):1391-5.
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EVOMED JAMIE RICHARDS

Nature Communications 2013, 4, 1860, doi:10.1038/ncomms2814. The genomics of selection in dogs and the parallel evolution between dogs and humans. Guo-dong Wang et al.

NEW RELEASES

CurraNZ

Fat oxidation

New Zealand Blackcurrant Improves Performance and Fat Oxidation in Cyclists, Willems ME1, Myers SD, Blacker S, Cook MD. European Journal of Applied Physiology, 2015

Diabetes/Obesity

Evaluation of Beneficial Metabolic Effects of Berries in High-Fat Fed C57BL/6J Mice. Lovisa Heyman,1 Ulrika Axling,1 Narda Blanco,2 Olov Sterner,2 Cecilia Holm,1 and Karin Berger1. Journal of Nutrition and Metabolism Volume 2014 (2014), Article ID 403041, http://dx.doi.org/10.1155/2014/403041 Published 14 January 2014

Postprandial glucose, insulin, and free fatty acid responses to sucrose consumed with blackcurrants and lingonberries in healthy women.Törrönen R1, Kolehmainen M, Sarkkinen E, Mykkänen H, Niskanen L. Am J Clin Nutr. 2012 Sep;96(3):527-33. doi: 10.3945/ajcn.112.042184. Epub 2012 Aug 1.

Anthocyanin increases adiponectin secretion and protects against diabetes-related endothelial dysfunction. Liu Y, Li D, Zhang Y, Sun R, Xia M. Am J Physiol Endocrinol Metab. 2014;306(8):E975-88.

Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes. Tsuda T, Ueno Y, Aoki H et al. Biochem Biophys Res Commun. 2004;316(1):149-57.

High Fat Meal Increase of IL-17 is Prevented by Ingestion of Fruit Juice Drink in Healthy Overweight Subjects. Peluso, IlariaRaguzzini, Anna Villano, Debora V Cesqui, EleonoraToti, ElisabettaCatasta, GiovinaSerafini, Mauro. CURRENT PHARMACEUTICAL DESIGN 2012, 18:

Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expres-sion in diabetic mice. Sasaki R, Nishimura N, Hoshino H, Isa Y, Kadowaki M, Ichi T, Tanaka A, Nishiumi S, Fukuda I, Ashida H, Horio F, Tsuda, T. (2007). Biochem Pharmacol. 2007; 74(11):1619-27

Polyphenol-rich blackcurrant extract prevents inflammation in diet-induced obese mice. Benn T1, Kim B1, Park YK1, Wegner CJ1, Harness E1, Nam TG2, Kim DO2, Lee JS3, Lee JY4. J Nutr Biochem. 2014 Oct;25(10):1019-25. doi: 10.1016/j.jnutbio.2014.05.008. Epub 2014 Jun 13.

Evaluation of Beneficial Metabolic Effects of Berries in High-Fat Fed C57BL/6J Mice. Heyman L1, Axling U1, Blanco N2, Sterner O2, Holm C1, Berger K1. J Nutr Metab. 2014;2014:403041. doi: 10.1155/2014/403041. Epub 2014 Jan 14.

Berry components inhibit α-glucosidase in vitro: synergies between acarbose and polyphenols from black currant and rowanber-ry.Boath AS1, Stewart D, McDougall GJ. Food Chem. 2012 Dec 1;135(3):929-36. doi: 10.1016/j.foodchem.2012.06.065. Epub 2012 Jul 1.

Polyphenol-rich extract from blackcurrant pomace attenuates the intestinal tract and serum lipid changes induced by a high-fat diet in rabbits. Jurgoński A1, Juśkiewicz J, Zduńczyk Z, Matusevicius P, Kołodziejczyk K. Eur J Nutr. 2014 Dec;53(8):1603-13. doi: 10.1007/s00394-014-0665-4. Epub 2014 Feb 6.

Cholesterol

Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects. Qin Y1, Xia M, Ma J, Hao Y, Liu J, Mou H, Cao L, Ling W. Am J Clin Nutr. 2009 Sep;90(3):485-92. doi: 10.3945/ ajcn.2009.27814. Epub 2009 Jul 29.

Polyphenol-rich blackcurrant extract exerts hypocholesterolaemic and hypoglycaemic effects in mice fed a diet containing high fat and cholesterol. Benn T1, Kim B1, Park YK1, Yang Y1, Pham TX1, Ku CS1, Farruggia C1, Harness E1, Smyth JA2, Lee JY1. Br J Nutr. 2015 Apr 22:1-7. [Epub ahead of print]

Antioxidants

Cyanidin and cyanidin 3-O-beta-D-glucoside as DNA cleavage protectors and antioxidants. Acquaviva R, Russo A, Galvano F, et al. Cell Biol Toxicol. 2003;19(4):243–252.

Isolation and free-radical scavenging proper-ties of cyanidin 3-O-glycosides from the fruits of Ribes A. Delazar, L. Khodaie, J. Afshar,L. Nahar and S. D. Sarker, biebersteinii Berl,Acta. Pharm., 2010, 60, 1–11.

Anthocyanins from black currants (Ribes nigrum L.), R. Slimestad and H. Solheim, J. Agric.Food Chem., 2002, 50, 3228–3231.

The health benefits of blackcurrants Ashwin Gopalan,a Sharon C. Reuben,a Shamima Ahmed,a Altaf S. Darvesh,a Judit Hohmannb and Anupam Bishayee*c et al J Med Food. 2012 Dec;15(12):1045-50. doi: 10.1089/jmf.2011.0316. Epub 2012 Jun 27

Vasodilation

Upregulation of endothelial nitric oxide synthase by cyanidin-3-glucoside, a typical anthocyanin pigment. Xu JW, Ikeda K, Yamori Y (2004). Hy-pertension 44, 217-222.

Effect of black currant anthocyanins on the activation of endothelial nitric oxide synthase (eNOS) in vitro in human endothelial cells. Edirisinghe I1, Banaszewski K, Cappozzo J, McCarthy D, Burton-Freeman BM. J Agric Food Chem. 2011 Aug 24;59(16):8616-24. doi: 10.1021/jf201116y. Epub 2011 Jul 28.

Effects of blackcurrant anthocyanin intake on peripheral muscle circulation during typing work in humans, H. Matsumoto, E. Takenami, K. Iwasaki-Kurashige, T. Osada, T. Katsumura and T.Hamaoka, Eur. J. Appl. Physiol., 2005, 94, 36–45.

Brain health

Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer’s disease. Vepsäläinen S1, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall GJ, Stewart D, Haapasalo A, Karjalainen RO, Tanila H, Hiltunen M. J Nutr Biochem. 2013 Jan;24(1):360-70. doi: 10.1016/j.jnutbio.2012.07.006. Epub 2012 Sep 17.

Acute supplementation with blackcurrant extracts modulates cognitive functioning and inhibits monoamine oxidase-B in healthy young adults Anthony W. Watsona, b, , , Crystal F. Haskell-Ramsaya, David O. Kennedya, Janine M. Cooneyb, Tania Trowerb, Arjan Scheepens. Journal of Functional Foods, Volume 17, August 2015, Pages 524-539

High fat meal increase of IL-17 is prevented by ingestion of fruit juice drink in healthy overweight subjects. Peluso I1, Raguzzini A, Villano DV, Cesqui E, Toti E, Catasta G, Serafini M. Curr Pharm Des. 2012;18(1):85-90.

Effects of anthocyanins and other phenolics of boysenberry and blackcurrant as inhibitors of oxidative stress and damage to cellular DNA in SH-SY5Y and HL-60 cells. Dilip Ghosh1,*, Tony K McGhie2, Jingli Zhang1, Aselle Adaim1 and Margot Skinner1. Journal of the Science of Food and Agriculture Volume 86, Issue 5, pages 678–686, 15 April 2006 Article first published online: 23 JAN 2006 DOI: 10.1002/jsfa.2409

Cytoprotective effects of anthocyanins and other phenolic fractions of Boysenberry and blackcurrant on dopamine and amyloid-induced oxidative stress in transfected COS-7 cells Dilip Ghosh, Tony K McGhie, Derek R Fisher, James A Joseph.Journal of the Science of Food and Agriculture

The impact of fruit flavonoids on memory and cognition. Spencer JP. Br J Nutr. 440 2010;104 Suppl 3; S40-7.

Neuroinflammation: modulation by flavonoids and mechanisms of action. Spencer JP1, Vafeiadou K, Williams RJ, Vauzour D. Mol Aspects Med. 2012 Feb;33(1):83-97. doi: 10.1016/j.mam.2011.10.016. Epub 2011 Nov 15.

The neuroprotective potential of flavonoids: a multiplicity of effects. Vauzour D1, Vafeiadou K, Rodriguez-Mateos A, Rendeiro C, Spencer JP Genes Nutr. 2008 Dec;3(3-4):115-26. doi: 10.1007/s12263-008-0091-4.Brain Res. 2014 Mar 25;1555:60-77. doi: 10.1016/j.brainres.2014.01.047. Epub 2014 Feb 3.

Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson’s disease. Strathearn KE1, Yousef GG2, Grace MH2, Roy SL1, Tambe MA1, Ferruzzi MG3, Wu QL4, Simon JE4, Lila MA2, Rochet JC5.

Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. Vauzour D. Oxid Med Cell Longev. 2012;2012:914273. doi: 10.1155/2012/914273. Epub 2012 Jun .

Beneficial effects of berry fruit polyphenols on neuronal and behavioural aging. Lau, F. C., Shukitt-Hale,B. and Joseph, J. A. (2006) J. Sci. Food Agric. 86, 2251 – 2255.

Effect of flavonoids on learning, memory and neurocognitive performance: relevance and potential implications for Alzheimer’s disease pathophysiology. Vauzour D. J Sci Food Agric. 2014 Apr;94(6):1042-56. doi: 10.1002/jsfa.6473. Epub 2013 Dec 12.

Cardio-protection

Effect of blackcurrant anthocyanins on the activation of endothelial nitric oxide synthase (eNOS) in vitro in human endothelial cells, I.Edirisinghe, K.Banaszewski, J.Cappozzo, D.McCarthy and B.M.Burton-Freeman, J.AGRIC.FOOD CHEM., 2011, 59, 8616-8624

Purified Anthocyanin Supplementation Improves Endothelial Function via NO-cGMP activation in Hypercholesterolemic Individuals. Zhu, Yanna Xia, Min Yang, Yan Liu, FengqiongLi, ZhongxiaHao, YuantaMi, Mantia Jin, TianruLing, Wenhua, CLINICAL CHEMISTRY 2011, 57 1524-1533.

Error! Hyperlink reference not valid., M.Rosenblat, N.Volkova, J.Attias, R.Mahamid and M.Aviram, FOOD FUNCT., 2010, 1, 99-109.

Anthocyanins in Cardiovascular Disease. Wallace. T.C. ADVANCES IN NUTRITION 2008. 2:1-7

Bioavailability and molecular activities of anthocyanins as modulators of endothelial function. Speciale A, Cimino F, Saija A, Canali R, Virgili F. Genes Nutr. 2014;9(4):404.

Delphinidin inhibits VEGF induced-mitochondrial biogenesis and Akt activation in endothelial cells. Duluc L1, Jacques C2, Soleti R3, Andriant¬sitohaina R4, Simard G5. Int J Biochem Cell Biol. 2014 Aug;53:9-14. doi: 10.1016/j.biocel.2014.03.030. Epub 2014 Apr 30.

Anthocyanin increases adiponectin secretion and protects against diabetes-related endothelial dysfunction. Liu Y, Li D, Zhang Y, Sun R, Xia M. Am J Physiol Endocrinol Metab. 2014;306(8):E975-88.

The endothelial plasma membrane transporter bilitranslocase mediates rat aortic vasodilation induced by anthocyanins. Ziberna L, Lunder M, Tramer F, Drevenšek G, Passamonti S. Nutr Metab Cardiovasc Dis. 2013;23(1):68-74.

Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease. Dalgård C1, Nielsen F, Morrow JD, Enghusen-Poulsen H, Jonung T, Hørder M, de Maat MP. Br J Nutr. 2009 Jan;101(2):263-9. doi: 10.1017/S0007114508995660. Epub 2008 May 28.

Intake of specific flavonoids and risk of acute myocardial infarction in Italy. Tavani, A., Spertini, L., Bosetti, C., Parpinel, M., Gnagnarella,P., Bravi, F., Peterson, J., Dwyer, J., Lagiou, P., Negri, E.and La Vecchia, C. (2006) Public HealthNutr. 9, 369 – 374.

RESEARCHJae H. Kang, Walter C. Willett, Bernard A. Rosner, Emmanuel Buys, Janey L. Wiggs, Louis R. Pasquale. Association of Dietary Nitrate Intake With Primary Open-Angle Glaucoma. JAMA Ophthalmology, 2016; 1 DOI: 10.1001/jamaophthalmol.2015.5601

St-Onge MP, Roberts A, Shechter A, Choudhury AR. Fiber and saturated fat are associated with sleep arousals and slow wave sleep. J Clin Sleep Med, 2016;12(1):19%u201324. DOI: 10.5664/jcsm.5384

Kelli A. Lytle, Donald B. Jump. Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible? PLOS ONE, 2016; 11 (1): e0146942 DOI: 10.1371/journal.pone.0146942

Erica D. Sonnenburg, Samuel A. Smits, Mikhail Tikhonov, Steven K. Higginbottom, Ned S. Wingreen, Justin L. Sonnenburg. Diet-induced extinctions in the gut microbiota compound over generations. Nature, 2016; 529 (7585): 212 DOI: 10.1038/nature16504

WELCOME

GBD 2013 Risk Factor Collaborators. Global, regional, and national comparative

risk assessment of 79 behavioural, environmental and occupational, and

metabolic risks or clusters of risks in 188 countries,1990–2013: a systematic

analysis for the Global Burden of Disease Study 2013.

Lancet. Published Online September 11, 2015http://dx.doi.org/10.1016/S0140-6736(15)00128-2

NEWSHomeopathyThere is no scientific case for homeopathy: the debate is over

Edzard Ernst: The Guardian, Thursday 12 March 2015: http://www.theguardian.com/commentisfree/2015/mar/12/no-scientific-case-homeopathy-remedies-pharmacists-placebos

House of Commons Science and Technology Committee – Fourth ReportEvidence Check 2: Homeopathy http://www.publications.parliament.uk/pa/cm200910/cmselect/cmsctech/45/4502.htmJeff Blandwww.jeffreybland.com.

YouTube video: https://www.youtube.com/watch?v=i8gbXjf6DbM

Update on Medical Practices That Should Be Questioned in 2015

Daniel J. Morgan, MD, MS1,2,3; Sanket S. Dhruva, MD4,5; Scott M. Wright, MD6; Deborah Korenstein, MD7

1Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore2Department of Hospital Epidemiology, Veterans Affairs Maryland Health Care System, Baltimore3Center for Disease Dynamics, Economics & Policy, Washington, DC4Robert Wood Johnson Foundation Clinical Scholars Program, Yale University School of Medicine, New Haven, Connecticut5Department of Veterans Affairs, West Haven, Connecticut6Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland7Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York

JAMA Intern Med. Published online November 09, 2015. doi:10.1001/jamainternmed.2015.5614).

Choosing Wisely in the UK: the Academy of Medical Royal Colleges’ initiative to reduce the harms of too much medicine

BMJ 2015; 350 doi: http://dx.doi.org/10.1136/bmj.h2308 (Published 12 May 2015)

FUNCTIONAL MEDICINE MASTERCLASS

BEN BROWN

1. Murray PJ, Wivell G, Denton E. Breast cancer screening and diagnosis in the 21st century within the UK. Post Reprod Health. 2015 Sep;21(3):105-11.

Independent UK Panel on Breast Cancer Screening. The benefits and harms of breast cancer screening: an independent review. Lancet 2012; 380: 1778–1786.
3. Cavalieri EL, Rogan EG. Unbalanced metabolism of endogenous estrogens in the etiology and prevention of human cancer. J Steroid Biochem Mol Biol. 2011 Jul;125(3-5):169-80.4. Sepkovic DW, Bradlow HL. Estrogen hydroxylation–the good and the bad. Ann N Y Acad Sci. 2009 Feb;1155:57-67. 5. Sepkovic DW, Bradlow HL. Estrogen hydroxylation–the good and the bad. Ann N Y Acad Sci. 2009 Feb;1155:57-67.6. Fowke JH, Longcope C, Hebert JR. Brassica vegetable consumption shifts estrogen metabolism in healthy postmenopausal women. Cancer Epidemiol Biomarkers Prev. 2000 Aug;9(8):773-9. 7. Reding KW, Atkinson C, Westerlind KC, Stanczyk F, Bowles EJ, Yong M, Newton KM, Lampe JW. Fruit intake associated with urinary estrogen metabolites in healthy premenopausal women. Open J Prev Med. 2012 Feb 23;2(1).8. Reding KW, Zahid M, Cavalieri E, Rogan EG, Raccor BS, Atkinson C, Yong M, Newton KM, Lampe JW. Associations between Dietary Intake of Fruits and Vegetables in relation to Urinary Estrogen DNA Adduct Ratio. Open J Prev Med. 2014 Jun;4(6):429-437.

Muran PJ, Muran SY, Beseler CL, Cavalieri EL, Rogan EG, Zahid M. Breast health and reducing breast cancer risk: a functional medicine approach. J Altern Complement Med. 2015 Jun;21(6):321-6.

STRESS

Szyf, M.. DNA methylation properties: consequences for pharmacology. Trends Pharmacol Sci 15: 233-238.

Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):684-9.

Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide.

Ramchandani S1, MacLeod AR, Pinard M, von Hofe E, Szyf M.

Nature. 1999 Feb 18;397(6720):579-83.

A mammalian protein with specific demethylase activity for mCpG DNA.

Bhattacharya SK1, Ramchandani S, Cervoni N, Szyf M.

Lei Cao-Lei, Renaud Massart, Matthew J. Suderman, Ziv Machnes, Guillaume Elgbeili, David P. Laplante, Moshe Szyf, Suzanne King. DNA Methylation Signatures Triggered by Prenatal Maternal Stress Exposure to a Natural Disaster: Project Ice Storm. PLoS ONE, 2014; 9 (9): e107653 DOI: 10.1371/journal.pone.0107653.

J Nutr. 2002 Aug;132(8 Suppl):2333S-2335S.Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline. Niculescu MD1, Zeisel SH.

J Neurosci. 2005 Nov 23;25(47):11045-54. Free online at : http://www.jneurosci.org/content/25/47/11045.longReversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life.Weaver IC1, Champagne FA, Brown SE, Dymov S, Sharma S, Meaney MJ, Szyf M.

Brain Res. 2008 Oct 27;1237:12-24. doi: 10.1016/j.brainres.2008.07.074. Epub 2008 Jul 29. Diet and the epigenetic (re)programming of phenotypic differences in behavior.

McGowan PO1, Meaney MJ, Szyf M.

Free online at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC295101

OPINION

Chew EY, et al. Effect of omega-3 fatty acids, lutein/zeaxanthin, or other nutrient supplementation on cognitive function: The AREDS2 randomized clinical trial. JAMA 2015;314:791-801. http://jama.jamanetwork.com/article.aspx?articleid=2429713Science 18 September 2015:Vol. 349 no. 6254 pp. 1343-1347DOI: 10.1126/science.aab2319

Greenlandic Inuit show genetic signatures of diet and climate adaptation

Matteo Fumagalli et al

RESEARCHEfficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Elderly: A Randomized, Double-Blind, Placebo-Controlled Trial

Liu, Guosonga; d; * | Weinger, Jason G.a | Lu, Zhong-Linb | Xue, Fengc | Sadeghpour, Safaa

Journal of Alzheimer’s Disease, vol. Preprint, no. Preprint, pp. 1-19, 2015

David Just and Brian Wansink (2015). Fast Food, Soft Drink, and Candy Intake is Unrelated to Body Mass Index for 95% of American Adults. Obesity Science & Practice, forthcoming. onlinelibrary.wiley.com/journal/10.1002/(ISSN)2055-2238

Ayelet Sivan, Leticia Corrales, Nathaniel Hubert, Jason B. Williams, Keston Aquino-Michaels, Zachary M. Earley, Franco W. Benyamin, Yuk Man Lei, Bana Jabri, Maria-Luisa Alegre, Eugene B. Chang, and Thomas F. Gajewski. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy. Science, November 2015 DOI: 10.1126/science.aac4255

Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseases

Bidisha Paul et al. Clinical Epigenetics 2015, 7:112

(doi: 10.1186/s13148-015-0144-7)

Matzkin, K. Suslavich, E. J. Curry. Lyme Disease Presenting as a Spontaneous Knee Effusion. Journal of the American Academy of Orthopaedic Surgeons, 2015; 23 (11): 674 DOI: 10.5435/JAAOS-D-14-00388
Carol Kumamoto et al. Manipulation of Host Diet To Reduce Gastrointestinal Colonization by the Opportunistic Pathogen Candida albicans. mSphere, November 2015 DOI: 10.1128/mSphere.00020-15

Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study Ulla Uusitalo, et al for the TEDDY Study Group

JAMA Pediatr. Published online November 09, 2015. doi:10.1001/jamapediatrics.2015.2757

Efficacy of Bright Light Treatment, Fluoxetine, and the Combination in Patients With Nonseasonal Major Depressive Disorder: A Randomized Clinical Trial.Raymond W. Lam, et al.

JAMA Psychiatry. Published online November 18, 2015.

(doi:10.1001/jamapsychiatry.2015.2235).

A. Kenfield, J. L. Batista, J. L. Jahn, M. K. Downer, E. L. Van Blarigan, H. D. Sesso, E. L. Giovannucci, M. J. Stampfer, J. M. Chan. Development and Application of a Lifestyle Score for Prevention of Lethal Prostate Cancer. JNCI Journal of the National Cancer Institute, 2015; 108 (3): djv329 DOI: 10.1093/jnci/djv329

NEWS

Peng Li, Stephanie C. Tjen-A-Looi, Ling Cheng, Dongmei Liu, Jeannette Painovich, Sivarama Vinjamury, John C. Longhurst. Long-Lasting Reduction of Blood Pressure by Electroacupuncture in Patients with Hypertension: Randomized Controlled Trial. Medical Acupuncture, 2015; 27 (4): 253 DOI: 10.1089/acu.2015.1106

BMC Biol. 2014; 12: 8. Published online 2013 Jan 31. doi: 10.1186/1741-7007-12-8

PMCID: PMC3909335. Cancer, metabolism, fructose, artificial sweeteners, and going cold turkey on sugar. Lewis C Cantley.

doi: 10.1186/1741-7007-12-8

Peng Li, Stephanie C. Tjen-A-Looi, Ling Cheng, Dongmei Liu, Jeannette Painovich, Sivarama Vinjamury, John C. Longhurst. Long-Lasting Reduction of Blood Pressure by Electroacupuncture in Patients with Hypertension: Randomized Controlled Trial. Medical Acupuncture, 2015; 27 (4): 253 DOI: 10.1089/acu.2015.1106

Rebecca I. Clark, Anna Salazar, Ryuichi Yamada, Sorel Fitz-Gibbon, Marco Morselli, Jeanette Alcaraz, Anil Rana, Michael Rera, Matteo Pellegrini, William W. Ja, David W. Walker. Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality. Cell Reports, 2015; 12 (10): 1656 DOI: 10.1016/j.celrep.2015.08.004.

BEN BROWN – Inflammation

1. Bested AC, Logan AC, Selhub EM. Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: Part I – autointoxication revisited. Gut Pathog. 2013 Mar 18;5(1):5. 2. Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, Neyrinck AM, Fava F, Tuohy KM, Chabo C, Waget A, Delmée E, Cousin B, Sulpice T, Chamontin B, Ferrières J, Tanti JF, Gibson GR, Casteilla L, Delzenne NM, Alessi MC, Burcelin R. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007 Jul;56(7):1761-72.3. Egger G, Dixon J. Beyond obesity and lifestyle: a review of 21st century chronic disease determinants. Biomed Res Int. 2014;2014:731685.4. Cani PD, Delzenne NM. The gut microbiome as therapeutic target. Pharmacol Ther. 2011 May;130(2):202-12.5. Amar J, Burcelin R, Ruidavets JB, Cani PD, Fauvel J, Alessi MC, Chamontin B, Ferriéres J. Energy intake is associated with endotoxemia in apparently healthy men. Am J Clin Nutr. 2008 May;87(5):1219-23.6. Ghanim H, Abuaysheh S, Sia CL, Korzeniewski K, Chaudhuri A, Fernandez-Real JM, Dandona P. Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance. Diabetes Care. 2009 Dec;32(12):2281-7

Pendyala S, Walker JM, Holt PR. A high-fat diet is associated with endotoxemia that originates from the gut. Gastroenterology. 2012 May;142(5):1100-1101.e2. doi: 10.1053/j.gastro.2012.01.034.
Xiao S, Fei N, Pang X, Shen J, Wang L, Zhang B, Zhang M, Zhang X, Zhang C, Li M, Sun L, Xue Z, Wang J, Feng J, Yan F, Zhao N, Liu J, Long W, Zhao L. A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome. FEMS Microbiol Ecol. 2014 Feb;87(2):357-67.
9. Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett. 2008 Dec;29(6):902-10.10. Albenberg LG, Wu GD. Diet and the intestinal microbiome: associations, functions, and implications for health and disease. Gastroenterology. 2014 May;146(6):1564-72.

Chassaing B, et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 2015 Mar 5;519(7541):92-6
12. David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA, Biddinger SB, Dutton RJ, Turnbaugh PJ. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014 Jan 23;505(7484):559-63.13. Dehghan P, Pourghassem Gargari B, Asghari Jafar-abadi M. Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized controlled clinical trial. Nutrition. 2014 Apr;30(4):418-23.14. Simon MC, Strassburger K, Nowotny B, Kolb H, Nowotny P, Burkart V, Zivehe F, Hwang JH, Stehle P, Pacini G, Hartmann B, Holst JJ, MacKenzie C, Bindels LB, Martinez I, Walter J, Henrich B, Schloot NC, Roden M. Intake of Lactobacillus reuteri Improves Incretin and Insulin Secretion in Glucose Tolerant Humans: A Proof of Concept. Diabetes Care. 2015 Jun 17. pii: dc142690. [Epub ahead of print]15. Sellmann C, Jin CJ, Degen C, De Bandt JP, Bergheim I. Oral Glutamine Supplementation Protects Female Mice from Nonalcoholic Steatohepatitis. J Nutr. 2015 Aug 5. pii: jn215517. [Epub ahead of print]16. de Souza AZ, Zambom AZ, Abboud KY, Reis SK, Tannihão F, Guadagnini D, Saad MJ, Prada PO. Oral supplementation with L-glutamine alters gut microbiota of obese and overweight adults: A pilot study. Nutrition. 2015 Jun;31(6):884-9.

Brimelow RE, et al. A Role for Whey-derived Lactoferrin and Immunoglobulins in the Attenuation of Obesity-related Inflammation and Disease? Crit Rev Food Sci Nutr. 2015 Jun 11:0. [Epub ahead of print]

Emma Lane – parasites

Crompton, D.W.T. 1999. How much human helminthiasis is there in the world? Journal of Parasitology 85(3): 397-403; The World Health Organization; and various additional published reviews

Journal of Parasitology 85:379-403 Dr. D.W.T. Crompton (Crompton, D.W.T. [1999How much human helminthiasis is there in the world?)

Gillespie S and Pearson R. Principles and Practice of Clinical Parasitology. John Wiley & Sons, Ltd. Chichester. ISBN: 0-471-97729-2. 2001

Leventhal R and Cheadle R. Medical Parasitology, A Self Instructional Text 6th Edition. F A Davis Company. Philadelphia. ISBN: 978-0-8036-2543-3. 2012.

Bush A, Fernandez J, Esch G and Seed J. Parasitism, The diversity and ecology of animal parasites. Cambridge University Press. Cambridge. ISBN: 0-521-66447-0. 2001.

Baron S. Medical Microbiology 4th Edition. University of Texas Medical Branch. Galveston. ISBN: 0-9631172-1-1. 1996

Mullin G. Integrative Gastroenterology. Oxford University Press. New York. ISBN 978-0-19537110-9. 2011.

Wright J and Lenard L. Why stomach acid is good for you. M. Evans and Company, Inc. New York. ISBN: 0-87131-931-4. 2001.

Pizzorno Jr J, Murray M and Joiner-Bey H. The Clinician’s Handbook of Natural Medicine 2nd Edition. Churchill Livingstone. Missouri. ISBN: 978-0-443-06723-5. 2008.

Liska D, Quinn S, Lukaczer D, Jones D and Lerman R. Clinical Nutrition, A Functional Approach. 2nd Edition. The Institute for Functional Medicine. Washington. ISBN: 978-0-9773713-2-7. 2006.

Lord R and Bralley J. Laboratory Evaluations for Integrative and Functional Medicine 2nd Edition. Genova Diagnostics. Duluth. ISBN: 978-0-9884322-0-8. 2012.

Lipski E. Digestive Wellness 4th Edition. McGraw Hill. New York. ISBN 978-0-07-166899-6. 2012.

The significance of bio-markers in the interpretation of comprehensive stool analysis results. By Omar M. Amin, B.Sc., M.Sc., Ph.D., USA Explore! Volume 20, Number 2, 2011

Detecting Microbes, By Omar M. Amin, B.Sc., M.Sc., Ph.D., USA, Chapter 15 of Optimal Digestive Heath – A Complete Guide, edited by Trent W Nichols, MD, and Nancy Faass, MSW MPH. Published by Healing Arts Press, Rochester Vermont Copyright 1999, 2005 by Nancy Faass and by Trent W Nichols, M.D.

Prevalence, Distribution, and Host Relationships of Cryptosporidium Parvum (Protozoa)
Infections in the United States, 2003-2005 © By Omar M. Amin, B.SC., M.SC., Ph.D., USA Explore! Volume 16, Number 1, 2006

The Epidemiology of Blastocystis horminis in the United States, By Omar M. Amin, B.Sc., M.Sc., Ph.D., USA, Research Journal of Parasitology 1 (1): 1-10, 2006

Prevalence, Distribution and Host Relationships of Cryptosporidium Parvum (Protozoa) Infections in the United States, 2003 – 2005 © By Omar M. Amin, B.SC., M.SC., Ph.D., USA . Explore! Volume 16, Number 1, 2006

RESEARCH

Mingguang He, Fan Xiang, Yangfa Zeng, Jincheng Mai, Qianyun Chen, Jian Zhang, Wayne Smith, Kathryn Rose, Ian G. Morgan. Effect of Time Spent Outdoors at School on the Development of Myopia Among Children in China. JAMA, 2015; 314 (11): 1142 DOI: 10.1001/jama.2015.10803

Michael X. Repka. Prevention of Myopia in Children. JAMA, 2015; 314 (11): 1137 DOI: 10.1001/jama.2015.10723

Logan NS, Davies LN, Mallen EA, Gilmartin B; Davies; Mallen; Gilmartin (April 2005). “Ametropia and ocular biometry in a U.K. university student population”. Optom Vis Sci 82 (4): 261–6. doi:10.1097/01.OPX.0000159358.71125.95. PMID 15829853.

Mokry LE, Ross S, Ahmad OS, Forgetta V, Smith GD, Leong A, et al. Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study. PLoS Med, 2015 DOI: 10.1371/journal.pmed.1001866

Ramagopalan SV, Heger A, Berlanga AJ, Maugeri NJ, Lincoln MR, Burrell A, Handunnetthi L, Handel AE, Disanto G, Orton S, Watson CT, Morahan JM, Giovannoni G, Ponting CP, Ebers GC, Knight JC. A ChIP-seq-defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution. Genome Research, 2010; DOI: 10.1101/gr.107920.110

McManus A et al (2015) Impact of prolonged sitting on vascular function in young girls. DOI: 10.1113/EP085355 http://onlinelibrary.wiley.com/doi/10.1113/EP085355/abstract

Cell Matbolism. Volume 22, Issue 2, p320–331, 4 August 2015. Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome

Saeed Shoaie et al. DOI: http://dx.doi.org/10.1016/j.cmet.2015.07.001

Tanya J Flynn, Murray Cadzow, Nicola Dalbeth, Peter B Jones, Lisa K Stamp, Jennie Harré Hindmarsh, Alwyn S Todd, Robert J Walker, Ruth Topless, Tony R Merriman. Positive association of tomato consumption with serum urate: support for tomato consumption as an anecdotal trigger of gout flares. BMC Musculoskeletal Disorders, 2015; 16 (1) DOI: 10.1186/s12891-015-0661-8

Paul S. Frenette et al. Neutrophil ageing is regulated by the microbiome. Nature, September 2015 DOI: 10.1038/nature15367.

S.A. Kim, H. Moon, K. Lee and M.S. Rhee. Bactericidal effects of triclosan in soap both in vitro and in vivo. Journal of Antimicrobial Chemotherapy, September 2015 DOI: 10.1093/jac/dkv275.

H. Moonaz, C. O. Bingham, L. Wissow, S. J. Bartlett. Yoga in Sedentary Adults with Arthritis: Effects of a Randomized Controlled Pragmatic Trial. The Journal of Rheumatology, 2015; 42 (7): 1194 DOI: 10.3899/jrheum.141129.

Liuyang Wang, Stefan H. Oehlers, Scott T. Espenschied, John F. Rawls, David M. Tobin, Dennis C. Ko. CPAG: software for leveraging pleiotropy in GWAS to reveal similarity between human traits links plasma fatty acids and intestinal inflammation. Genome Biology, 2015; 16 (1) DOI: 10.1186/s13059-015-0722-1

Estefanía Toledo, Jordi Salas-Salvadó, Carolina Donat-Vargas, Pilar Buil-Cosiales, Ramón Estruch, Emilio Ros, Dolores Corella, Montserrat Fitó, Frank B. Hu, Fernando Arós, Enrique Gómez-Gracia, Dora Romaguera, Manuel Ortega-Calvo, Lluís Serra-Majem, Xavier Pintó, Helmut Schröder, Josep Basora, José Vicente Sorlí, Mònica Bulló, Merce Serra-Mir, Miguel A. Martínez-González. Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial. JAMA Internal Medicine, 2015; 1 DOI: 10.1001/jamainternmed.2015.4838
S. Turner, R. G. Thomas, S. Craft, C. H. van Dyck, J. Mintzer, B. A. Reynolds, J. B. Brewer, R. A. Rissman, R. Raman, P. S. Aisen. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology, 2015; DOI: 10.1212/WNL.0000000000002035

EN BROWN

1. Karell K, Louka AS, Moodie SJ, Ascher H, Clot F, Greco L, Ciclitira PJ, Sollid LM, Partanen J; European Genetics Cluster on Coeliac Disease. HLA types in coeliac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Coeliac Disease. Hum Immunol. 2003 Apr;64(4):469-77.2. Trynka G, Hunt KA, Bockett NA, et al. Dense genotyping identifies and localizes multiple common and rare variant association signals in coeliac disease. Nat Genet. 2011 Nov 6;43(12):1193-201.3. Lohi S, Mustalahti K, Kaukinen K, Laurila K, Collin P, Rissanen H, Lohi O, Bravi E, Gasparin M, Reunanen A, Mäki M. Increasing prevalence of coeliac disease over time. Aliment Pharmacol Ther. 2007 Nov 1;26(9):1217-25.4. Catassi C, Kryszak D, Bhatti B, Sturgeon C, Helzlsouer K, Clipp SL, Gelfond D, Puppa E, Sferruzza A, Fasano A. Natural history of coeliac disease autoimmunity in a USA cohort followed since 1974. Ann Med. 2010 Oct;42(7):530-8.5. West J, Fleming KM, Tata LJ, Card TR, Crooks CJ. Incidence and prevalence of coeliac disease and dermatitis herpetiformis in the UK over two decades: population-based study. Am J Gastroenterol. 2014 May;109(5):757-68.6. Kasarda DD. Can an increase in coeliac disease be attributed to an increase in the gluten content of wheat as a consequence of wheat breeding? J Agric Food Chem. 2013 Feb 13;61(6):1155-9.7. Freeman HJ. Coeliac disease: a disorder emerging from antiquity, its evolving classification and risk, and potential new treatment paradigms. Gut Liver. 2015 Jan;9(1):28-37.8. Størdal K, Haugen M, Brantsæter AL, Lundin KE, Stene LC. Association between maternal iron supplementation during pregnancy and risk of coeliac disease in children. Clin Gastroenterol Hepatol. 2014 Apr;12(4):624-31.e1-2.

Ludvigsson JF, Murray JA, Adams PC, et al. Does hemochromatosis predispose to coeliac disease? A study of 29,096 coeliac disease patients. Scand J Gastroenterol. 2013;48:176–182
10. Tanpowpong P, Obuch JC, Jiang H, McCarty CE, Katz AJ, Leffler DA, Kelly CP, Weir DC, Leichtner AM, Camargo CA Jr. Multicenter study on season of birth and coeliac disease: evidence for a new theoretical model of pathogenesis. J Pediatr. 2013 Mar;162(3):501-4.11. Ivarsson A, Hernell O, Nyström L, Persson LA. Children born in the summer have increased risk for coeliac disease. J Epidemiol Community Health. 2003 Jan;57(1):36-9.12. Lebwohl B, Green PH, Murray JA, Ludvigsson JF. Season of birth in a nationwide cohort of coeliac disease patients. Arch Dis Child. 2013 Jan;98(1):48-51.13. Tanpowpong P, Camargo CA. Early-life vitamin D deficiency and childhood-onset coeliac disease. Public Health Nutr. 2014 Apr;17(4):823-6.

Sandberg-Bennich S, Dahlquist G, Ka¨lle´n B. Coeliac disease is associated with intrauterine growth and neonatal infections. Acta Paediatr. 2002;91:30–33.
Myle´us A, Hernell O, Gothefors L, et al. Early infections are associated with increased risk for coeliac disease: an incident casereferent study. BMC Pediatr. 2012;19(12):194.
Riddle MS, Murray JA, Cash BD, Pimentel M, Porter CK. Pathogen-specific risk of coeliac disease following bacterial causes of foodborne illness: a retrospective cohort study. Dig Dis Sci. 2013 Nov;58(11):3242-5.
17. Keenan JI, Day AS. Risks for coeliac disease: bacteria make it three. Dig Dis Sci. 2013 Nov;58(11):3066-7.18. Lebwohl B, Ludvigsson JF, Green PH. The unfolding story of coeliac disease risk factors. Clin Gastroenterol Hepatol. 2014 Apr;12(4):632-

FATIGUE

M Hornig, G Gottschalk, D L Peterson, K K Knox, A F Schultz, M L Eddy, X Che, W I Lipkin. Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome. Molecular Psychiatry, 2015; DOI: 10.1038/mp.2015.29

Roumiana S. Boneva, Jin-Mann S. Lin, Elizabeth R. Unger. Early menopause and other gynecologic risk indicators for chronic fatigue syndrome in women. Menopause, 2015; 1 DOI: 10.1097/GME.0000000000000411

Mady Hornig, José G. Montoya, Nancy G. Klimas, Susan Levine, Donna Felsenstein, Lucinda Bateman, Daniel L. Peterson, C. Gunnar Gottschalk, Andrew F. Schultz, Xiaoyu Che, Meredith L. Eddy, Anthony L. Komaroff, W. Ian Lipkin. Distinct plasma immune signatures in ME/CFS are present early in the course of illness. Science Advances, 2015 DOI: 10.1126/sciadv.1400121Anne Pemberton

Bosque P. Vitamin B12 deficiency – Epidemiology. Medmerits [Internet]. 2014 [cited 2015 Aug 15]; Available from: http://www.medmerits.com/index.php/article/vitamin_b12_deficiency/P6
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Goringe A, Ellis R, McDowell I, et al. The limited value of methylmalonic acid, homocysteine and holotranscobalamin in the diagnosis of early B12 deficiency. Haematologica 2006;91:231-4.
Mitchell ES, Conus N, Kaput J. B vitamin polymorphisms and behavior: evidence of associations with neurodevelopment, depression, schizophrenia, bipolar disorder and cognitive decline. Neurosci Biobehav Rev [Internet]. 2014 Nov [cited 2015 Aug 15];47:307–20. Available from: http://www.sciencedirect.com/science/article/pii/S0149763414002048
NEW RELEASES

BMC Complement Altern Med. 2011; 11: 16.

Published online 2011 Feb 25. doi: 10.1186/1472-6882-11-16

PMCID: PMC3056848

Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses

Christian Krawitz,#

Global Information Hub on Integrated Medicine entry on elderberry: http://www.globinmed.com/index.php?option=com_content&view=article&id=83212:sambucus-nigra&catid=860:s#35

ANTIOXIDANTSUnraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits

Michael Ristow Nature Medicine 20, 709–711 (2014)

doi:10.1038/nm.3624

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

Michael Ristowa, b, , , Kim Zarsea Experimental Gerontology (doi:10.1038/nm.3624). Volume 45, Issue 6, June 2010, Pages 410–418

Cell Death and Differentiation (2015) 22, 377–388; doi:10.1038/cdd.2014.150; published online 26 September 2014. Oxidative stress and autophagy: the clash between damage and metabolic needsG Filomeni1,2, D De Zio1,2 and F Cecconi1,2

Hum Mol Genet. 2010 Sep 1; 19(17): 3413–3429.

Published online 2010 Jun 21. doi: 10.1093/hmg/ddq253

PMCID: PMC2916709

Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease

Benjamin R. Underwood,1 Sara Imarisio,1,2 Angeleen Fleming,1,3 Claudia Rose,1 Gauri Krishna,1,2 Phoebe Heard,2 Marie Quick,1,3 Viktor I. Korolchuk,1 Maurizio Renna,1 Sovan Sarkar,1 Moisés García-Arencibia,1 Cahir J. O’Kane,2 Michael P. Murphy,4 and David C. Rubinsztein1,*

Orthop Res. 2014 Jul;32(7):937-43. doi: 10.1002/jor.22608. Epub 2014 Mar 18.

Do antioxidants inhibit oxidative-stress-induced autophagy of tenofibroblasts?

Kim RJ1, Hah YS, Sung CM, Kang JR, Park HB.

Am J Clin Nutr 2005, vol. 81 no. 1 215S-217S Polyphenols: antioxidants and beyond.

Augustin Scalbert,

Ian T Johnson, and

Mike Saltmarsh

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Med Sci Monit. 2008 Nov;14(11):CR547-51.

Vitamin C-lipid metabolites: uptake and retention and effect on plasma C-reactive protein and oxidized LDL levels in healthy volunteers.

Pancorbo D1, Vazquez C, Fletcher MA.

Suhong Xu, Andrew D. Chisholm. C. elegans Epidermal Wounding Induces a Mitochondrial ROS Burst that Promotes Wound Repair. Developmental Cell, 2014; 31 (1): 48 DOI: 10.1016/j.devcel.2014.08.002

mtDNA Mutagenesis Disrupts Pluripotent Stem Cell Function by Altering Redox Signaling. C

Riikka H. Hämäläinen,

Kati J. Ahlqvist,

Pekka Ellonen

Maija Lepistö,

Angela Logan,

Timo Otonkoski,

Michael P. Murphy,

Anu Suomalainen

Open Access

Cell Reports, Volume 11, Issue 10, p1614–1624, 16 June 2015 DOI: http://dx.doi.org/10.1016/j.celrep.2015.05.009

RESEARCH UPDATE

Brendan J. Guercio, Kaori Sato, Donna Niedzwiecki, Xing Ye, Leonard B. Saltz, Robert J. Mayer, Rex B. Mowat, Renaud Whittom, Alexander Hantel, Al Benson, Daniel Atienza, Michael Messino, Hedy Kindler, Alan Venook, Frank B. Hu, Shuji Ogino, Kana Wu, Walter C. Willett, Edward L. Giovannucci, Jeffrey A. Meyerhardt, and Charles S. Fuchs. Coffee Intake, Recurrence, and Mortality in Stage III Colon Cancer: Results From CALGB 89803 (Alliance). Journal of Clinical Oncology, August 2015 DOI: 10.1200/JCO.2015.61.5062

Saccharomyces boulardii CNCM I-745 supports regeneration of the intestinal microbiota after diarrheic dysbiosis – a review. Moré MI, Swidsinski A

Clinical and Experimental Gastroenterology August 2015 Volume 2015:8 Pages 237—255 DOI http://dx.doi.org/10.2147/CEG.S85574

The Effect of Body Posture on Brain Glymphatic Transport

Hedok Lee1,2,*, et al . The Journal of Neuroscience, 5 August 2015, 35(31): 11034-11044; (doi: 10.1523/JNEUROSCI.1625-15.2015).

Science 18 October 2013: Vol. 342 no. 6156 pp. 373-377 DOI: 10.1126/science.1241224. Sleep Drives Metabolite Clearance from the Adult Brain

Lulu Xie1,*, et al.

Gail D. Sckisel, Myriam N. Bouchlaka, Arta M. Monjazeb, Marka Crittenden, Brendan D. Curti, Danice E.C. Wilkins, Kory A. Alderson, Can M. Sungur, Erik Ames, Annie Mirsoian, Abhinav Reddy, Warren Alexander, Athena Soulika, Bruce R. Blazar, Dan L. Longo, Robert H. Wiltrout, William J. Murphy. Out-of-Sequence Signal 3 Paralyzes Primary CD4 T-Cell-Dependent Immunity. Immunity, 2015; 43 (2): 240 DOI: 10.1016/j.immuni.2015.06.023

Reiko Horai, Carlos R. Zárate-Bladés, Patricia Dillenburg-Pilla, Jun Chen, Jennifer L. Kielczewski, Phyllis B. Silver, Yingyos Jittayasothorn, Chi-Chao Chan, Hidehiro Yamane, Kenya Honda, Rachel R. Caspi. Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site. Immunity, 2015; 43 (2): 343 DOI: 10.1016/j.immuni.2015.07.014

Laura Steenbergen, Roberta Sellaro, Ann-Kathrin Stock, Christian Beste, Lorenza S. Colzato. γ-Aminobutyric acid (GABA) administration improves action selection processes: a randomised controlled trial. Scientific Reports, 2015; 5: 12770 DOI: 10.1038/srep12770

Denise K. Houston, Janet A. Tooze, Jamehl L. Demons, Brooke L. Davis, Rachel Shertzer-Skinner, Linda B. Kearsley, Stephen B. Kritchevsky, Jeff D. Williamson. Delivery of a Vitamin D Intervention in Homebound Older Adults Using a Meals-on-Wheels Program: A Pilot Study. Journal of the American Geriatrics Society, 2015; DOI: 10.1111/jgs.13610

Kevin D. Hall, Thomas Bemis, Robert Brychta, Kong Y. Chen, Amber Courville, Emma J. Crayner, Stephanie Goodwin, Juen Guo, Lilian Howard, Nicolas D. Knuth, Bernard V. Miller, Carla M. Prado, Mario Siervo, Monica C. Skarulis, Mary Walter, Peter J. Walter, Laura Yannai. Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity. Cell Metabolism, 2015; DOI: 10.1016/j.cmet.2015.07.021

EDITOR’S NOTE

Nature 444, 1027-1031 (21 December 2006) | doi:10.1038/nature05414;

An obesity-associated gut microbiome with increased capacity for energy harvest

Peter J. Turnbaugh1, Ruth E. Ley1, Michael A. Mahowald1, Vincent Magrini2, Elaine R. Mardis1,2 & Jeffrey I. Gordon1

NEWSGluten psychosis: confirmation of a new clinical entity

Nutrients. 2015 Jul 8;7(7):5532-5539. Full text free online at http://www.mdpi.com/2072-6643/7/7/5235/htm.

Lionetti E1, Leonardi S2, Franzonello C3, Mancardi M4, Ruggieri M5, Catassi C6,7.

NUTRIGENOMICS

Dolinoy D. The agouti mouse model: an epigenetic biosensor for nutritional and environmental alterations on the fetal epigenome. Nutr Rev; 2008; 66

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Huebner FR, Lieberman KW, Rubino RP, Wall JS. Demonstration of high opioidlike activity in isolated peptides from wheat gluten hydrolysates. Peptides 1984;5(6):1139–
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10. Lister J, Fletcher PJ, Nobrega JN, Remington G. Behavioral effects of food-derived opioid-like peptides in rodents: Implications for schizophrenia? Pharmacol Biochem Behav. 2015 Jul;134:70-78.

Dohan FC. Wheat “consumption” and hospital admissions for schizophrenia during World War II. A preliminary report. Am J Clin Nutr. 1966;18:7–10.
Dohan FC, Harper EH, Clark MH, Rodrigue RB, Zigas V: Is schizophrenia rare if grain is rare? Biol Psychiatry1984, 19(3):385-399.
13. Peet M. International variations in the outcome of schizophrenia and the prevalence of depression in relation to national dietary practices: an ecological analysis. Br J Psychiatry. 2004 May;184:404-8.14. Francis H, Stevenson R. The longer-term impacts of Western diet on human cognition and the brain. Appetite. 2013 Apr;63:119-28.

Pacheco A, Easterling WS, Pryer MW: A pilot study of the ketogenic diet in schizophrenia. Am J Psychiatry1965, 121:1110-1111.
Kraft BD, Westman EC. Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature. Nutr Metab. 2009;6:1–3.
17. Porcelli B, Verdino V, Bossini L, Terzuoli L, Fagiolini A. Celiac and non-celiac gluten sensitivity: a review on the association with schizophrenia and mood disorders. Auto Immun Highlights. 2014 Oct 16;5(2):55-61. 18. Samaroo D, Dickerson F, Kasarda DD, Green PH, Briani C, Yolken RH, Alaedini A. Novel immune response to gluten in individuals with schizophrenia. Schizophr Res. 2010 May;118(1-3):248-55.

Jackson J, Eaton W, Cascella N, Fasano A, Warfel D, Feldman S, Richardson C, Vyas G, Linthicum J, Santora D, Warren KR. A gluten-free diet in people with schizophrenia and anti-tissue transglutaminase or anti-gliadin antibodies. Schizophr Res. 2012;140:262–263.
20. Genuis SJ, Lobo RA. Gluten sensitivity presenting as a neuropsychiatric disorder. Gastroenterol Res Pract. 2014;2014:293206.21. Wang HR, Woo YS, Bahk WM. Caffeine-induced psychiatric manifestations: a review. Int Clin Psychopharmacol. 2015 Jul;30(4):179-82.

Hedges DW, Woon FL, Hoopes SP. Caffeine-induced psychosis. CNS Spectr. 2009 Mar;14(3):127-9.
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Peng PJ, Chiang KT, Liang CS. Low-dose caffeine may exacerbate psychotic symptoms in people with schizophrenia. J Neuropsychiatry Clin Neurosci. 2014 Apr 1;26(2):E41.

BONES

Arthroscopy. 2015 Apr;31(4):785-92. doi: 10.1016/j.arthro.2014.11.021) Epub 2015 Jan 27. Supplementary methods in the nonsurgical treatment of osteoarthritis.

Percope de Andrade MA1, Campos TV2, Abreu-E-Silva GM2.

Maturitas. 2014 Jul;78(3):184-7. doi: 10.1016/j.maturitas.2014.04.015. Epub 2014 May 1.What is the current status of chondroitin sulphate and glucosamine for the treatment of knee osteoarthritis? Henrotin Y1, Marty M2, Mobasheri A3.

J Pharm Pharm Sci. 2011;14(2):264-73. The glucosamine controversy; a pharmacokinetic issue. Aghazadeh-Habashi A1, Jamali F.

Management of Osteoarthritis with Avocado/Soybean Unsaponifiables

Blaine A. Christiansen, Simrit Bhatti, Ramin Goudarzi, Shahin Emami (Cartilage, 2105 Vol. 6(1) 30–44. , doi: 10.1177/1947603514554992).

Biological actions of curcumin on articular chondrocytes Y. Henrotiny* a , A. L. Clutterbuckz, D. Allawayx, E. M. Lodwigx, P. Harrisx, M. Mathy-Harterty, M. Shakibaeik and A. Mobasheri. Osteoarthritis and Cartilage (2010) 18, 141e149 ª 2009 doi:10.1016/j.joca.2009.10.002

Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management. Yves Henrotin, Fabian Priem and Ali Mobasheri. (SpringerPlus 2013, 2:56 doi:10.1186/2193-1801-2-56.

Nicholas A. Young, Michael S. Bruss, Mark Gardner, William L. Willis, Xiaokui Mo, Giancarlo R. Valiente, Yu Cao, Zhongfa Liu, Wael N. Jarjour, Lai-Chu Wu. Oral Administration of Nano-Emulsion Curcumin in Mice Suppresses Inflammatory-Induced NFκB Signaling and Macrophage Migration. PLoS ONE, 2014; 9 (11): e111559 DOI: 10.1371/journal.pone.0111559

Buhrmann, A. Mobasheri, F. Busch, C. Aldinger, R. Stahlmann, A. Montaseri, M. Shakibaei. Curcumin Modulates Nuclear Factor B (NF- B)-mediated Inflammation in Human Tenocytes in Vitro: ROLE OF THE PHOSPHATIDYLINOSITOL 3-KINASE/Akt PATHWAY. Journal of Biological Chemistry, 2011; 286 (32): 28556 DOI: 10.1074/jbc.M111.256180

RESEARCH

Alison Fildes, Judith Charlton, Caroline Rudisill, Peter Littlejohns, A. Toby Prevost, Martin C. Gulliford. Probability of an Obese Person Attaining Normal Body Weight: Cohort Study Using Electronic Health Records. American Journal of Public Health, 2015; e1 DOI: 10.2105/AJPH.2015.302773

Brianna Cote, Lisa Janssen Carlson, Deepa A. Rao, Adam W.G. Alani. Combinatorial resveratrol and quercetin polymeric micelles mitigate doxorubicin induced cardiotoxicity in vitro and in vivo. Journal of Controlled Release, 2015; 213: 128 DOI: 10.1016/j.jconrel.2015.06.040

Strekalova, D. Malin, D. M. Good, V. L. Cryns. Methionine Deprivation Induces a Targetable Vulnerability in Triple-Negative Breast Cancer Cells by Enhancing TRAIL Receptor-2 Expression. Clinical Cancer Research, 2015; 21 (12): 2780 DOI: 10.1158/1078-0432.CCR-14-2792
Shai Efrati, Haim Golan, Yair Bechor, Yifat Faran, Shir Daphna-Tekoah, Gal Sekler, Gregori Fishlev, Jacob N. Ablin, Jacob Bergan, Olga Volkov, Mony Friedman, Eshel Ben-Jacob, Dan Buskila. Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial. PLOS ONE, 2015; 10 (5): e0127012 DOI: 10.1371/journal.pone.0127012

Nneka M. George, Julia Whitaker, Giovana Vieira, Jerome T. Geronimo, Dwight A. Bellinger, Craig A. Fletcher, Joseph P. Garner. Antioxidant Therapies for Ulcerative Dermatitis: A Potential Model for Skin Picking Disorder. PLOS ONE, 2015 DOI: 10.1371/journal.pone.0132092

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Ranking the impact of human health disorders on gut metabolism: Systemic lupus erythematosus and obesity as study cases. David Rojo et al. Scientific Reports 2015,

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Frits Koning, Nature Reviews Rheumatology 2015, Published online

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Unrecognized Celiac Disease in Children Presenting for Rheumatology Evaluation

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Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates

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RESEARCH

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

Sebastian Brandhorst et al. Cell Metabolism, Published Online: June 18, 2015.

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Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression

Chia-Wei Cheng et al, Cell Stem Cell 2014, Volume 14, Issue 6, p810–823, 5 June 2014.

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Antoine Louveau, Igor Smirnov, Timothy J. Keyes, Jacob D. Eccles, Sherin J. Rouhani, J. David Peske, Noel C. Derecki, David Castle, James W. Mandell, Kevin S. Lee, Tajie H. Harris, Jonathan Kipnis. Structural and functional features of central nervous system lymphatic vessels. Nature, 2015; DOI: 10.1038/nature14432

Yasmine Belkaid et al. Bone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection. Immunity, June 2015 DOI: 10.1016/j.immuni.2015.05.011

Beatrice Alexandra Golomb, Alexis K. Bui. A Fat to Forget: Trans Fat Consumption and Memory. PLOS ONE, 2015; 10 (6): e0128129 DOI: 10.1371/journal.pone.0128129.

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Angela Man, Eugenio Bertelli, Silvia Rentini, Mari Regoli, Graham Briars, Mario Marini, Alastair Watson, Claudio Nicoletti. Age-associated modifications of intestinal permeability and innate immunity in human small intestine. Clinical Science, 2015; DOI: 10.1042/CS20150046

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Bret T. Howrey, M. Kristen Peek, Juliet M. McKee, Mukaila A. Raji, Kenneth J. Ottenbacher, and Kyriakos S. Markides

Chamomile Consumption and Mortality: A Prospective Study of Mexican Origin Older Adults. The Gerontologist first published online April 29, 2015 (doi:10.1093/geront/gnv051).

Daynea J Wallock-Richards, Jon Marles-Wright, David Clarke, Amarnath Maitra, Michael Dodds, Bryan Hanley, Dominic Campopiano. Molecular Basis of Streptococcus mutans Sortase A Inhibition by the Flavonoid Natural Product trans-Chalcone. Chem. Commun., 2015; DOI:10.1039/C5CC01816A

NEWSextra

Khan Z, Combadière C, Authier F-J et al. Slow CCL2-dependent translocation of biopersistent particles from muscle to brain. BMC Medicine 2013, 11:99. DOI: 10.1186/1741-7015-11-99.

BEN BROWN

van Os J, Kapur S. Schizophrenia. Lancet. 2009 Aug 22;374(9690):635-45.

Perälä J, Suvisaari J, Saarni SI, et al. Lifetime prevalence of psychotic and bipolar I disorders in a general population. Arch Gen Psychiatry. 2007 Jan;64(1):19-28.

Insel TR. Rethinking schizophrenia. Nature. 2010 Nov 11;468(7321):187-93.

Novick D, Haro JM, Hong J, Brugnoli R, Lepine JP, Bertsch J, Karagianis J, Dossenbach M, Alvarez E: Regional differences in treatment response and three year course of schizophrenia across the world. J Psychiatr Res 2012, 46:856-864.

Leucht S, Corves C, Arbter D, Engel RR, Li C, Davis JM. Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet. 2009 Jan 3;373(9657):31-41.

Harrow M, Jobe TH, Faull RN. Does treatment of schizophrenia with antipsychotic medications eliminate or reduce psychosis? A 20-year multi-follow-up study. Psychol Med. 2014 Oct;44(14):3007-16.

Moncrieff J. Why is it so difficult to stop psychiatric drug treatment? It may be nothing to do with the original problem. Med Hypotheses. 2006;67(3):517-23.

Hoffer A, OsmondH, CallbeckMJ, Kahan I. Treatment of schizophrenia with nicotinic acid and nicotinamide. J Clin Exp Psychopathol 1957;18:131–158.

Hoffer, JL. Vitamin Therapy in Schizophrenia. Isr J Psychiatry Relat Sci Vol 45 No. 1 (2008) 3–10

Hoffer A, Osmond H. Treatment of schizophrenia with nicotinic acid. A ten year follow-up. Acta Psychiatr Scand. 1964;40:171-189.

Pauling L. Orthomolecular psychiatry. Varying the concentrations of substances normally present in the human body may control mental disease. Science. 1968;160(825):265-271

Ames BN, Elson-Schwab I, Silver EA. High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affi nity (increased K(m)): relevance to genetic disease and polymorphisms. Am J Clin Nutr. 2002;75(4):616-658.

Hoffer LJ: Orthomolecular psychiatry: past, pres­ent and future. J Orthomol Med, 2010; 25:56-66.

Prousky JE: The orthomolecular treatment of schizophrenia: a primer for clinicians. Townsend Lett Doctors Patients, 2007; February/March: 86-100.

Sarris J, et al. Nutritional medicine as mainstream in psychiatry. Lancet Psychiatry 2015; 271–74

ENVIRONMENTAL HEALTH

Aitana Lertxundi, Michela Baccini, Nerea Lertxundi, Eduardo Fano, Aritz Aranbarri, Maria Dolores Martínez, Mikel Ayerdi, Jon Álvarez, Loreto Santa-Marina, Miren Dorronsoro, Jesus Ibarluzea. Exposure to fine particle matter, nitrogen dioxide and benzene during pregnancy and cognitive and psychomotor developments in children at 15months of age. Environment International, 2015; 80: 33 DOI: 10.1016/j.envint.2015.03.007

Mark Pimentel, Walter Morales, Ali Rezaie, Emily Marsh, Anthony Lembo, James Mirocha, Daniel A. Leffler, Zachary Marsh, Stacy Weitsman, Kathleen S. Chua, Gillian M. Barlow, Enoch Bortey, William Forbes, Allen Yu, Christopher Chang. Development and Validation of a Biomarker for Diarrhea-Predominant Irritable Bowel Syndrome in Human Subjects. PLOS ONE, 2015; 10 (5): e0126438 DOI: 10.1371/journal.pone.0126438

Cosmetics

Sathyanarayana S, Karr CJ, Lozano P, Brown E, Calafat AM, Liu F, Swan SH. 2008. Baby care products: possible sources of infant phthalate exposure. Pediatrics. Feb;121(2):e260-8.

Swan SH, Main KM, Liu F, et al; Study for Future Families Research Team. 2005. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Health Perspect. Aug;113(8):1056-61.

Swan SH, Liu F, Hines M, Kruse RL, Wang C, Redmon JB, Sparks A, Weiss B. 2010. Prenatal phthalate exposure and reduced masculine play in boys. Int J Androl. Apr;33(2):259-69.

EFAsJoseph G Gleeson et al. Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome. Nature Genetics, May 2015 DOI: 10.1038/ng.3311

Andrew H Crosby et al. A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome. Nature Genetics, May 2015 DOI: 10.1038/ng.3313

Jaewoo Choi, Scott W. Leonard, Katherine Kasper, Melissa McDougall, Jan F. Stevens, Robert L. Tanguay, Maret G. Traber. Novel function of vitamin E in regulation of zebrafish (Danio rerio) brain lysophospholipids discovered using lipidomics. Journal of Lipid Research, 2015; jlr.M058941 DOI: 10.1194/jlr.M058941

Aron Barbey et al. Anterior cingulate cortex mediates the relationship between O3PUFAs and executive functions in APOE e4 carriers. Frontiers in Aging Neuroscience, May 2015 DOI: 10.3389/fnagi.2015.00087

Adrian Raine, Jill Portnoy, Jianghong Liu, Tashneem Mahoomed, Joseph R. Hibbeln. Reduction in behaviour problems with omega-3 supplementation in children aged 8-16 years: a randomized, double-blind, placebo-controlled, stratified, parallel-group trial. Journal of Child Psychology and Psychiatry, 2015; 56 (5): 509 DOI: 10.1111/jcpp.12314

Gong Cheng, Changzhen Fu, Hong Wang, C. Adoligbe, Shengjuan Wei, Shijun Li, Bijie Jiang, Hongbao Wang, Linsen Zan. Production of transgenic beef cattle rich in n-3 PUFAs by somatic cell nuclear transfer. Biotechnology Letters, 2015; DOI: 10.1007/s10529-015-1827-z

Hanna Shevalye, Matthew S Yorek, Lawrence J Coppey, Amey Holmes, Matthew M Harper, Randy H Kardon, Mark A. Yorek. Effect of enriching the diet with menhaden oil or daily treatment with resolvin D1 on neuropathy in a mouse model of type 2 diabetes. Journal of Neurophysiology, 2015; jn.00224.2015 DOI: 10.1152/jn.00224.2015

Xiaoming Jia, Mohammadreza Pakseresht, Nour Wattar, Jamie Wildgrube, Stephanie Sontag, Murphy Andrews, Fatheema Begum Subhan, Linda McCargar, Catherine J. Field. Women who take n-3 long-chain polyunsaturated fatty acid supplements during pregnancy and lactation meet the recommended intake. Applied Physiology, Nutrition, and Metabolism, 2015; 1 DOI: 10.1139/apnm-2014-0313

Molecular Psychiatry advance online publication 24 March 2015; doi: 10.1038/mp.2015.22).Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept studyM H Rapaport1, A A Nierenberg2, P J Schettler1, B Kinkead1, A Cardoos2, R Walker2 and D Mischoulon2

RESEARCH UPDATE

Bäckhed et al. Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life. Cell Host & Microbe, May 2015 DOI: 10.1016/j.chom.2015.04.004

Vangay et al. Antibiotics, Pediatric Dysbiosis, and Disease. Cell Host & Microbe, May 2015 DOI: 10.1016/j.chom.2015.04.006

Fujimura et al. Microbiota in Allergy and Asthma and the Emerging Relationship with the Gut Microbiome. Cell Host & Microbe, May 2015 DOI: 10.1016/j.chom.2015.04.007

Vandana Gulati, Pankaj Gulati, Ian H Harding, Enzo A Palombo. Exploring the anti- diabetic potential of Australian Aboriginal and Indian Ayurvedic plant extracts using cell-based assays. BMC Complementary and Alternative Medicine, 2015; 15 (1) DOI: 10.1186/s12906-015-0524-8

Esther Lopez-Garcia, Luz Leon-Muñoz, Pilar Guallar-Castillon, Fernando Rodríguez-Artalejo. Habitual Yoghurt Consumption and Health-Related Quality of Life: A Prospective Cohort Study. Journal of the Academy of Nutrition and Dietetics, 2015; 115 (1): 31 DOI: 10.1016/j.jand.2014.05.013

IHCAN May references

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Joe Pizzorno 1. Wikoff, WR, Anfora AT, Liu J, et al. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A. 2009;106(10):3698-3703. doi: 10.1073/pnas.0812874106 2. The Free Dictionary by Farlex. Endotoxin. http://medical-dictionary. thefreedictionary.com/endotoxin. Accessed October 31, 2014. 3. Neves AL, Coelho J, Couto L, et al. Metabolic endotoxemia: A molecular link between obesity and cardiovascular risk. J Mol Endocrinol. 2013;51(2):R51-R64 4. Cani PD, Amar J, Iglesias MA, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56(7):1761-1772. 5. Lassenius MI, Pietiläinen KH, Kaartinen K, et al. Bacterial endotoxin activity in human serum is associated with dyslipidemia, insulin resistance, obesity, and chronic inflammation. Diabetes Care. 2011;34(8):1809-1815. 6. Alisi A, Manco M, Devito R, et al. Endotoxin and plasminogen activator inhibitor-1 serum levels associated with nonalcoholic steatohepatitis in children. J Pediatr Gastroenterol Nutr. 2010;50(6):645-649. 7. Shah R, Hinkle CC, Haris L, et al. Adipose genes down-regulated during experimental endotoxemia are also suppressed in obesity. J Clin Endocrinol Metab. 2012;97(11):E2152-E2159. 8. Dial S, Delaney JA, Barkun AN, Suissa S. Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease. JAMA. 2005;294(23): 2989-2995. 9. Pizzorno J. Zonulin! The wheat conundrum solved (well, mostly …). Integrat Med Clin J. 2013;12(4):8-14. 10. de Kort S, Keszthelyi D, Masclee AA. Leaky gut and diabetes mellitus: What is the link? Obes Rev. 2011;12(6):449-458. 11. Leclercq S, Matamoros S, Cani PD, et al. Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity. Proc Natl Acad Sci U S A. 2014;111(42):E4485-E4493. 12. 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Rosell-Camps A, Zibetti S, Pérez-Esteban G, Vila-Vidal M, Ferrés-Ramis L, García-Teresa-García E. Histamine intolerance as a cause of chronic digestive complaints in pediatric patients. Rev Esp Enferm Dig. 2013 Apr;105(4):201-6. 20. Johnston CS, Martin LJ, Cai X. Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis. J Am Coll Nutr. 1992 Apr;11(2):172-6. 21. Martner-Hewes PM, Hunt IF, Murphy NJ, Swendseid ME, Settlage RH. Vitamin B-6 nutriture and plasma diamine oxidase activity in pregnant Hispanic teenagers. Am J Clin Nutr. 1986 Dec;44(6):907-13. 22. Büttner L, Achilles N, Böhm M, Shah-Hosseini K, Mösges R. Efficacy and tolerability of bromelain in patients with chronic rhinosinusitis–a pilot study. B-ENT. 2013;9(3):217-25 23. Oksaharju A, Kankainen M, Kekkonen RA, Lindstedt KA, Kovanen PT, Korpela R, Miettinen M. Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells. World J Gastroenterol. 2011 Feb 14;17(6):750-9. doi: 10.3748/wjg.v17.i6.750 24. Betsi GI, Papadavid E, Falagas ME. Probiotics for the treatment or prevention of atopic dermatitis: a review of the evidence from randomized controlled trials. Am J Clin Dermatol. 2008;9(2):93-103. GUT HEALTH and RESEARCH UPDATE Junki Miyamoto, Taichi Mizukure, Si-Bum Park, Shigenobu Kishino, Ikuo Kimura, Kanako Hirano, Paolo Bergamo, Mauro Rossi, Takuya Suzuki, Makoto Arita, Jun Ogawa, Soichi Tanabe. A Gut Microbial Metabolite of Linoleic Acid, 10-Hydroxy-cis-12-octadecenoic Acid, Ameliorates Intestinal Epithelial Barrier Impairment Partially via GPR40-MEK-ERK Pathway. Journal of Biological Chemistry, 2015; 290 (5): 2902 DOI: 10.1074/jbc.M114.610733 Am J Obstet Gynecol. 2015 Feb 14. pii: S0002-9378(15)00130-1. doi: 10.1016/j.ajog.2015.02.008. [Epub ahead of print] Impact of probiotics in women with gestational diabetes mellitus on metabolic health: a randomized controlled trial. Lindsay KL1, Brennan L2, Kennelly MA1, Maguire OC3, Smith T3, Curran S4, Coffey M5, Foley ME1, Hatunic M6, Shanahan F7, McAuliffe FM8. J F Vázquez-Castellanos, S Serrano-Villar, A Latorre, A Artacho, M L Ferrús, N Madrid, A Vallejo, T Sainz, J Martínez-Botas, S Ferrando-Martínez, M Vera, F Dronda, M Leal, J Del Romero, S Moreno, V Estrada, M J Gosalbes, A Moya. Altered metabolism of gut microbiota contributes to chronic immune activation in HIV-infected individuals. Mucosal Immunology, 2014; DOI: 10.1038/mi.2014.107 A. Morgun, A. Dzutsev, X. Dong, R. L. Greer, D. J. Sexton, J. Ravel, M. Schuster, W. Hsiao, P. Matzinger, N. Shulzhenko. Uncovering effects of antibiotics on the host and microbiota using transkingdom gene networks. Gut, 2015; DOI: 10.1136/gutjnl-2014-308820 Daniela Grimaldi, Federica Provini, Giulia Pierangeli, Natalia Mazzella, Giovanni Zamboni, Giulio Marchesini, Pietro Cortelli. Evidence of a diurnal thermogenic handicap in obesity. 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Clinical & Experimental Allergy, 2015; 45 (3): 632 DOI: 10.1111/cea.12487 NEWS Benoit Chassaing, Omry Koren, Julia K. Goodrich, Angela C. Poole, Shanthi Srinivasan, Ruth E. Ley, Andrew T. Gewirtz. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature, 2015; DOI: 10.1038/nature14232 Lerner A1, Matthias T2. Autoimmun Rev. 2015 Feb 9. pii: S1568-9972(15)00024-5. doi: 10.1016/j.autrev.2015.01.009. [Epub ahead of print]. Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease. Nutrients. 2015 Feb 27;7(3):1565-76. doi: 10.3390/nu7031565. Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity. Hollon J, Puppa EL, Greenwald B, Goldberg E, Guerrerio A, Fasano A. 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NEW RELEASES Vojdani A. Detection of IgE, IgG, IgA and IgM antibodies against raw and processed food antigens. Nutr Metab (Lond). 2009 May 12;6:22. doi: 10.1186/1743-7075-6-22. CONFERENCE Oschman, J.L., 2008. Energy Medicine and Longevity. Chapter 27 in Anti-Aging Therapeutics, Volume X, Edited by Klatz, R. and Goldman, R., American Academy of Anti-Aging Medicine, Chicago IL, pp. 211-218.

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