REFERENCES

A full online archive of references

7
October 2018

NEWS

Jørgensen L, Gøtzsche P, Jefferson T. The Cochrane HPV vaccine review was incomplete and ignored important evidence of bias. BMJ Evid Based Med 2018, Jul 27.
Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors. Cochrane Database Syst Rev2018;5:CD009069.pmid:29740819.

Index of the human papillomavirus (HPV) vaccine industry clinical study programmes and non-industry funded studies: a necessary basis to address reporting bias in a systematic review. Syst Rev 2018;7:8. doi:10.1186/s13643-018-0675-z pmid:29347995.

HPV vaccine safety: Cochrane launches urgent investigation into review after criticisms. BMJ 2018; 362 doi: https://doi.org/10.1136/bmj.k3472 (Published 09 August 2018).

Greenhalgh T, Howick J, Maskrey N; Evidence Based Medicine Renaissance Group. Evidence based medicine: a movement in crisis? BMJ. 2014 Jun 13;348:g3725. doi: 10.1136/bmj.g3725.

 Resveratrol Supplementation Reduces Pain and Inflammation in Knee Osteoarthritis Patients Treated with Meloxicam: A Randomized Placebo-Controlled Study. Published Online ahead of print Journal of Medicinal Food, August 30, 2018: https://doi.org/10.1089/jmf.2017.4176. (Free access to October 17.)

Cell 2018 Sep 6;174(6):1388-1405.e21. doi: 10.1016/j.cell.2018.08.041.

Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features.

A randomized placebo-controlled clinical trial of a multi-strain probiotic formulation

(Bio-Kult®) in the management of diarrhea-predominant irritable bowel syndrome.

Ishaque et al. BMC Gastroenterology 2018, 18:71: https://doi.org/10.1186/s12876-018-0788-9.

Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome

Gastroenterology, Volume 153, Issue 2, August 2017, Pages 448-459.e8.

Does probiotic consumption reduce antibiotic utilization for common acute infections? A systematic review and meta-analysis 

European Journal of Public Health, cky185, https://doi.org/10.1093/eurpub/cky185

Published: 14 September 2018.

Qingqing Zhang, Yucheng Wu, Xiaoqiang Fei. Effect of probiotics on body weight and body-mass index: a systematic review and meta-analysis of randomized, controlled trialsInternational Journal of Food Sciences and Nutrition, 2016; 67 (5): 571 DOI: 10.1080/09637486.2016.1181156.

Elmira Akbari, Zatollah Asemi, Reza Daneshvar Kakhaki, Fereshteh Bahmani, Ebrahim Kouchaki, Omid Reza Tamtaji, Gholam Ali Hamidi, Mahmoud Salami. Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer’s Disease: A Randomized, Double-Blind and Controlled TrialFrontiers in Aging Neuroscience, 2016; 8 DOI: 10.3389/fnagi.2016.00256

Anna G. Nilsson, Daniel Sundh, Fredrik Bäckhed, Mattias Lorentzon. Lactobacillus reuteri reduces bone loss in older women with low bone mineral density – a randomized, placebo-controlled, double-blind, clinical trialJournal of Internal Medicine, 2018; DOI: 10.1111/joim.12805.

BEN BROWN

  1. Kim MH, Kim H. The Roles of Glutamine in the Intestine and Its Implication in  Intestinal Diseases. Int J Mol Sci. 2017 May 12;18(5)
  2. Rao R, Samak G. Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions. J Epithel Biol Pharmacol. 2012 Jan;5(Suppl 1-M7):47-54.
  3. Sido B, Seel C, Hochlehnert A, Breitkreutz R, Dröge W. Low intestinal glutamine level and low glutaminase activity in Crohn’s disease: a rational for glutamine supplementation? Dig Dis Sci. 2006 Dec;51(12):2170-9.
  4. Jonas CR, Ziegler TR. Potential role of glutamine administration in inflammatory bowel disease. Nestle Nutr Workshop Ser Clin Perform Programme. 1999;2:217-30
  5. Shinozaki M, Saito H, Muto T. Excess glutamine exacerbates trinitrobenzenesulfonic acid-induced colitis in rats. Dis Colon Rectum 1997; 40 (suppl): 59–63.
  6. Benjamin J, Makharia G, Ahuja V, Anand Rajan KD, Kalaivani M, Gupta SD, Joshi  YK. Glutamine and whey protein improve intestinal permeability and morphology in  patients with Crohn’s disease: a randomized controlled trial. Dig Dis Sci. 2012 Apr;57(4):1000-12.
  7. Den Hond E, Hiele M, Peeters M, Ghoos Y, Rutgeerts P. Effect of long-term oral glutamine supplements on small intestinal permeability in patients with Crohn’s disease. JPEN J Parenter Enteral Nutr. 1999;23:7–11.
  8. Akobeng AK, Miller V, Stanton J, Elbadri AM, Thomas AG. Double-blind randomized controlled trial of glutamine-enriched polymeric diet in the treatment of active Crohn’s disease. J Pediatr Gastroenterol Nutr. 2000 Jan;30(1):78-84.
  9. Alpers DH. Glutamine: do the data support the cause for glutamine supplementation in humans? Gastroenterology. 2006 Feb;130(2 Suppl 1):S106 16.
  10. Zhou Q, Costinean S, Croce CM, et al. MicroRNA 29 targets nuclear factor-kappaB-repressing factor and Claudin 1 to increase intestinal permeability. Gastroenterology 2015; 148:158-169.e8
  11. Zhou Q, Verne ML, Fields JZ, Lefante JJ, Basra S, Salameh H, Verne GN. Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome. Gut. 2018 Aug 14. pii: gutjnl-2017-315136.
  12. Ford AC, Lacy BE, Talley NJ. Longo DL, editor. Irritable bowel syndrome. N Engl J Med2017;376:2566–78
  13. Olden K. Targeted therapies for diarrhea-predominant irritable bowel syndrome. Clin Exp Gastroenterol 2012;5:69–100
  14. Schoenfeld P, Pimentel M, Chang L, Lembo A, Chey WD, Yu J, Paterson C, Bortey  E, Forbes WP. Safety and tolerability of rifaximin for the treatment of irritable bowel syndrome without constipation: a pooled analysis of randomised, double-blind, placebo-controlled trials. Aliment Pharmacol Ther. 2014 May;39(10):1161-8.
  15. Pimentel M, Lembo A, Chey WD, et al Rifaximin therapy for patients with irritable bowel syndrome without constipation. N Engl J Med 2011; 364: 22–32
  16. Ishaque SM, Khosruzzaman SM, Ahmed DS, Sah MP. A randomized placebo-controlled clinical trial of a multi-strain probiotic formulation (Bio-Kult®) in the management of diarrhea-predominant irritable bowel syndrome. BMC Gastroenterol. 2018 May 25;18(1):71.
  17. Hod K, Sperber AD, Ron Y, Boaz M, Dickman R, Berliner S, Halpern Z, Maharshak  N, Dekel R. A double-blind, placebo-controlled study to assess the effect of a probiotic mixture on symptoms and inflammatory markers in women with diarrhea-predominant IBS. Neurogastroenterol Motil. 2017 Jul;29(7).
  18. Bertiaux-Vandaele N, Youmba SB, Belmonte L, et al. The expression and the cellular distribution of the tight junction proteins are altered in irritable bowel syndrome patients with differences according to the disease subtype. Am J Gastroenterol 2011; 106:2165-2173.

Glutamine not for cancer
Gaurav Pathria, David A Scott, Yongmei Feng, Joo Sang Lee, Yu Fujita, Gao Zhang, Avinash D Sahu, Eytan Ruppin, Meenhard Herlyn, Andrei L Osterman, Ze’ev A Ronai. Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survivalThe EMBO Journal, 2018; e99735 DOI: 10.15252/embj.201899735

PARASITES – EMMA LANE

Acute cold exposure induces vagally mediated Fos expression in gastric myenteric neurons in conscious rats. Yuan PQ1, Taché Y, Miampamba M, Yang H. Pubmed. 281(2):G560-8. Published online Aug  2001. 2001

Auricular Acupuncture and Vagal Regulation. Wei He, Xiaoyu Wang, Hong Shi, Hongyan Shang, Liang Li, Xianghong Jing, and Bing Zhu. Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 786839, http://dx.doi.org/10.1155/2012/786839

Autonomic nervous function during whole-body cold exposure before and after cold acclimation. Mäkinen TM1, Mäntysaari M, Pääkkönen T, Jokelainen J, Palinkas LA, Hassi J, Leppäluoto J, Tahvanainen K, Rintamäki H. Pubmed. 79(9):875-82. Published online 2008 sept. PMID: 18785356. 2008.

Bonaz, B. “Vagal tone: effects on sensitivity, motility, and inflammation.” Neurogastroenterology & motility 28 no. 4 :455-62. 2016.

Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats. Mager DE1, Wan R, Brown M, Cheng A, Wareski P, Abernethy DR, Mattson MP. FASEB J. 20(6):631-7. Apr 2006.

Cardiovascular and Respiratory Effect of Yogic Slow Breathing in the Yoga Beginner: What Is the Best Approach? Heather Mason, Matteo Vandoni, Giacomo deBarbieri, Erwan Codrons, Veena Ugargol, and Luciano Bernardi. Evidence-Based Complementary and Alternative Medicine. 2013. Volume 2013, Article ID 743504, 7; Published 22 March 2013.

Changes in Autonomic Variables Following Two Meditative States Described in Yoga Texts. Shirley Telles, Bhat Ramachandra Raghavendra, Kalkuni Visweswaraiah Naveen, Nandi Krishnamurthy Manjunath, Sanjay Kumar, Pailoor Subramanya. J Altern Complement Med. 19(1): 35–42. doi: 10.1089/acm.2011.0282. PMCID: PMC3546358. Jan 2013.

Chloe Faith Wordsworth, Spiral Up, ISBN:978-1-937710-03-3

Could Vagus Nerve Stimulation Target Hippocampal Hyperactivity to Improve Cognition in Schizophrenia? Jason Smucny, Adrienne Visani, Jason R. Tregellas. Front Psychiatry. 6: 43. Published online 2015 Mar 24. doi: 10.3389/fpsyt.2015.00043. PMCID: PMC4371554. 2015.

Dunstan, DW. et al. Television viewing time and mortality: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab). Circulation. 2010 Jan 26;121(3):384-91. doi: 10.1161/CIRCULATIONAHA.109.894824. Epub 2010 Jan 11. Accessed 14th September 2016.

Effect of laughter yoga on mood and heart rate variability in patients awaiting organ transplantation: a pilot study. Dolgoff-Kaspar R1, Baldwin A, Johnson MS, Edling N, Sethi GK. Pubmed. (5):61-6. Published online 2012 sept-oct PMID: 22894892. 2012.

Grontved A, Hu FB. Television viewing and risk of type 2 diabetes, cardiovascular disease, and all-cause mortality: a meta-analysis. JAMA. 2011;305:2448-55.

He, X., et al. “Novel strategies and underlying protective mechanisms of modulation of vagal activity in cardiovascular diseases.” British Journal of Pharmacology 172 no. 23: 5489-500. 2015.

Healy, GN. Breaks in sedentary time: beneficial associations with metabolic risk. Diabetes Care. 2008 Apr;31(4):661-6. doi: 10.2337/dc07-2046. Epub 2008 Feb 5. Accessed 7th October 2016.

Henson, J. et al. Associations of objectively measured sedentary behaviourand physical activity with markers of cardiometabolic health. 2012 Nov. Diabetologia. DOI 10.1007/s00125-013-2845-9. Accessed 7th October 2016

http://www.bu.edu/news/2012/03/07/researchers-find-yoga-helps-ease-stress-related-medical-and-psychological-conditions/

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF. Proc Natl Acad Sci U S A.108(38):16050-5.  Epub 2011 Aug 29. PMID:21876150. Sep 20 2011.

Jessen NA., et al. The Glymphatic System: A Beginner’s Guide. Neurochem Res. 2015 Dec;40(12):2583-99. doi: 10.1007/s11064-015-1581-6. Epub 2015 May 7. Accessed 14th September 2016.

Just Breathe: Body Has A Built-In Stress Reliever, Gretchen Cuda. NPR article December 6th 2010.

Katy Bowman, Move Your DNA, Edition 1, ISBN:978-1905367573

Music structure determines heart rate variability of singers. Björn Vickhoff, Helge Malmgren, Rickard Åström, Gunnar Nyberg, Seth-Reino Ekström, Mathias Engwall, Johan Snygg, Michael Nilsson, Rebecka Jörnsten. Front Psychol. 2013; 4: 334. Published online Jul 9 2013. doi: 10.3389/fpsyg.2013.00334. PMCID: PMC3705176.

Neurohemodynamic correlates of ‘OM’ chanting: A pilot functional magnetic resonance imaging study. Bangalore G Kalyani, Ganesan Venkatasubramanian, Rashmi Arasappa, Naren P Rao, Sunil V Kalmady, Rishikesh V Behere, Hariprasad Rao, Mandapati K Vasudev, Bangalore N Gangadhar. Int J Yoga.; 4(1): 3–6. doi: 10.4103/0973-6131.78171. PMCID: PMC3099099. Jan-Jun 2011.

Omega-3 Polyunsaturated Fatty Acids and Heart Rate Variability. Jeppe Hagstrup Christensen Front Physiol. 2: 84. Published online Nov 16 2011. Prepublished online 2011 Oct 4. doi:  10.3389/fphys.2011.00084. 2011.

Parasympathetic nervous system activity predicts mood repair use and its effectiveness among adolescents with and without histories of major depression. Ilya Yaroslavsky, Jonathan Rottenberg, Lauren M. Bylsma, J. Richard Jennings, Charles George, Ildikó Baji, István Benák, Roberta Dochnal, Kitti Halas, Krisztina Kapornai, J Abnorm Psychol. Author manuscript; available in PMC Published online 2016 Mar 7. doi: 10.1037/abn0000149. PMCID: PMC5025532. Apr 1 2017.

Perceived Positive Social Connections Account for the Upward Spiral Between Positive Emotions and Vagal Tone  Bethany E. Kok, Kimberly A. Coffey, Michael A. Cohn. Volume: 24 issue: 7, page(s): 1123-1132.  Article first published online: May 6, 2013; Issue published: July 1, 2013. https://doi.org/10.1177/0956797612470827.

Pilorz V., et al. Melanopsin Regulates Both Sleep-Promoting and Arousal-Promoting Responses to Light. PLOS Biology. June 8, 2016. doi: 10.1371/journal.pbio.1002482. Accessed 14th September 2016.

Role of the vagus nerve in the development and treatment of diet‐induced obesity. Guillaume de Lartigue. J Physiol. 594(20): 5791–5815. Published online 2016 May 29. doi: 10.1113/JP271538. PMCID: PMC5063945. Oct 15 2016.

Rosenburg S, Accessing the Healing power of the Vagus Nerve, North Atlantic Books, California, ISBN 978-1-62317-024-0. 2017.

The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Marilia Carabotti, Annunziata Scirocco, Maria Antonietta Maselli, Carola Severi. Ann Gastroenterol. 2015 Apr-Jun; 28(2): 203–209. Correction in: Ann Gastroenterol. 29(2): 240.  PMCID: PMC4367209. Apr-Jun 2016.

Tyaqi, A., et al. “Yoga and heart rate variability: A comprehensive review of the literature.” International journal of yoga 9, no. 2  97-113. 2016.

Vagal nerve regulation is essential for the increase in gastric motility in response to mild exercise. Wang Y1, Kondo T, Suzukamo Y, Oouchida Y, Izumi S. Pubmed. 2:155-63. Published online Oct 22 2010.  PMID: 20948179. 2010.

Vagus Nerve Stimulation (VNS) and Treatment of Depression: To the Brainstem and Beyond. John P. O’Reardon, Pilar Cristancho, Andrew D. Peshek. Psychiatry (Edgmont) 3(5): 54–63. Published online 2006 May. PMCID: PMC2990624. May 2006.

Wiley T.S., Lights Out, Edition,1, ISBN:0-671-03868-0

Wilfred R Pigeon, Sleep manual, Edition,1, ISBN:978-0-76419737-6

Xie, L., et al. (2013). Sleep Drives Metabolite Clearance from the Adult Brain. Science, 342(6156), 373-377.

Yoga and heart rate variability: A comprehensive review of the literature. Anupama Tyagi, Marc Cohen. Int J Yoga. 9(2): 97–113. doi: 10.4103/0973-6131.183712. PMCID: PMC4959333. Jul-Dec 2016.

Picture caption

  1. Xie, H. Kang, Q. Xu, M. J. Chen, Y. Liao, M. Thiyagarajan, J. O’Donnell, D. J. Christensen, C. Nicholson, J. J. Iliff, T. Takano, R. Deane, M. Nedergaard. Sleep Drives Metabolite Clearance from the Adult Brain. Science, 2013; 342 (6156): 373 DOI: 10.1126/science.1241224.

SUPERFOODS
Microalgae, a Potential Natural Functional Food Source – a Review. Angélica Villarruel-López , Felipe Ascencio , Karla Nuño. Pol. J. Food Nutr. Sci 2017, Vol. 67, 4, 251–263. DOI: 10.1515/pjfns-2017-0017.
Elizabeth Stanley Shepherd, William C. DeLoache, Kali M. Pruss, Weston R. Whitaker, Justin L. Sonnenburg. An exclusive metabolic niche enables strain engraftment in the gut microbiotaNature 2018; DOI: 10.1038/s41586-018-0092-4

Fernando F Anhê et al. Treatment with camu camu (Myrciaria dubia) prevents obesity by altering the gut microbiota and increasing energy expenditure in diet-induced obese miceGut, 2018; gutjnl-2017-315565 DOI: 10.1136/gutjnl-2017-315565.
A Double-Blind Placebo-Controlled Trial of Maca Root as Treatment for Antidepressant-Induced Sexual Dysfunction in Women. Christina M. Dording et al.

Evid Based Complement Alternat Med. 2015; 2015: 949036. DOI: 10.1155/2015/949036.

Mushrooms
Abdullah N, et al Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities . Evid Based Complement Alternat Med. (2012)

Abdulla MA., Noor S., Sabaratnam V., N. Abdullah, Wong KH., Ali HM.. Effect of Culinary-Medicinal Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae), on Ethanol-Induced Gastric Ulcers in Rats. International Journal for Medicinal Mushrooms.DOI: 10.1615/IntJMedMushr.v10.i4.40. 325-330 pages

Kodama N, Komuta K, Nanba H. Can maitake MD-fraction aid cancer patients?

Altern Med Rev. 2002 Jun;7(3):236-9.

Çağlarirmak N., 2011. Edible mushrooms: an alternative food item, mushroom biology and mushroom products — In: Proceedings of the 7th International Conference on Mushroom Biology and Mushroom Products. Arcachon, France, pp. 553–559.

Ganoderma lucidum and its pharmaceutically active compounds. Boh B, Berovic M, Zhang J, ZhiBinL. Biotechnol Annu Rev. 2007;13:265-301.

Jayachandran M, Xiao J, Xu B. A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota. International Journal of Molecular Sciences. 2017;18(9):1934. doi:10.3390/ijms18091934.

Nanba H. Antitumor activity of orally administered “D-Fraction” from maitake mushroom (Grifola frondosa). J Naturopathic Med 1993;1:10-15.

Tang W, Gao Y, Chen G, Gao H, Dai X, et al. A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia. J Med Food. 2005 Spring;8(1):53-8. PubMed PMID: 15857210.

http://doi.org/10.1089/jmf.2005.8.53

Shang, X. et al. (2013) In vitro anti-Helicobacter pylori effects of medicinal mushroom extracts, with special emphasis on the Lion’s Mane mushroom, Hericium erinaceus (higher Basidiomycetes). International Journal of Medicinal Mushrooms. 15(2), pp. 165–174.

Siu K.C., Chen X., Wu J.Y. Constituents actually responsible for the antioxidant

activities of crude polysaccharides isolated from mushrooms. Journal of Functional Foods; 11: 548-556: (2014)

Wong YY, Moon A, Duffin R, Barthet-Barateig A, Meijer HA, Clemens MJ, de Moor CH (2010). Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction. J Biol Chem 285(4):2610-21.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788765/

RESEARCH

Ageing

  1. Jay Olshansky. From Lifespan to HealthspanJAMA, 2018. DOI: 10.1001/jama.2018.12621

The Future of Health. S. Jay Olshansky PhD. Controversies in Geriatrics and Gerontology,  First published 5 December 2017. https://doi.org/10.1111/jgs.15167.

  1. Kaluza, N. Håkansson, H. R. Harris, N. Orsini, K. Michaëlsson, A. Wolk. Influence of anti-inflammatory diet and smoking on mortality and survival in men and women: two prospective cohort studiesJournal of Internal Medicine, 2018; DOI: 10.1111/joim.12823

Sarah S. Stith, Jacob M. Vigil, Franco Brockelman, Keenan Keeling, Branden Hall. Patient-Reported Symptom Relief Following Medical Cannabis ConsumptionFrontiers in Pharmacology, 2018; 9 DOI: 10.3389/fphar.2018.00916

Jacob Vigil, Sarah Stith, Jegason Diviant, Franco Brockelman, Keenan Keeling, Branden Hall. Effectiveness of Raw, Natural Medical Cannabis Flower for Treating Insomnia under Naturalistic ConditionsMedicines, 2018; 5 (3): 75 DOI: 10.3390/medicines5030075.

Joseph H. Skalski, Jose J. Limon, Purnima Sharma, Matthew D. Gargus, Christopher Nguyen, Jie Tang, Ana Lucia Coelho, Cory M. Hogaboam, Timothy R. Crother, David M. Underhill. Expansion of commensal fungus Wallemia mellicola in the gastrointestinal mycobiota enhances the severity of allergic airway disease in mice. PLOS Pathogens, 2018; 14 (9): e1007260 DOI: 10.1371/journal.ppat.1007260.

Chao Jiang, Xin Wang, Xiyan Li, Jingga Inlora, Ting Wang, Qing Liu, Michael Snyder. Dynamic Human Environmental Exposome Revealed by Longitudinal Personal MonitoringCell, 2018; 175 (1): 277 DOI: 10.1016/j.cell.2018.08.060.

Matcha green tea (MGT) inhibits the propagation of cancer stem cells (CSCs), by targeting mitochondrial metabolism, glycolysis and multiple cell signalling pathways. Aging 2018, 10 (8): 1867-83. Gloria Bonuccelli  , Federica Sotgia  , Michael P. Lisant.

J Bernadette Moore, Annabelle Horti, Barbara A Fielding. Evaluation of the nutrient content of yoghurts: a comprehensive survey of yoghurt products in the major UK supermarketsBMJ Open, 2018; 8 (8): e021387 DOI: 10.1136/bmjopen-2017-021387.

September 2018

WELCOME

Ileocecal valve dysfunction in small intestinal bacterial overgrowth: A pilot study

Larry S MillerAnil K VegesnaAiswerya Madanam SampathShital PrabhuSesha Krishna Kotapati, and Kian Makipour

World J Gastroenterol. 2012 Dec 14; 18(46): 6801–6808.

Published online 2012 Dec 14. doi:  10.3748/wjg.v18.i46.6801

Low ileocecal valve pressure is significantly associated with small intestinal bacterial overgrowth (SIBO).

Roland BC1Ciarleglio MMClarke JOSemler JRTomakin EMullin GEPasricha PJ.

Dig Dis Sci. 2014 Jun;59(6):1269-77. doi: 10.1007/s10620-014-3166-7. Epub 2014 May 3.

NEWS

Association of Maternal Insecticide Levels With Autism in Offspring From a National Birth Cohort. Am J Psychiatry. Published Online:16 Aug 2018. https://doi.org/10.1176/appi.ajp.2018.17101129

The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity. Immunity 2018, 49, 2: 353-62. E5. Open Access Published: August 14. DOI: https://doi.org/10.1016/j.immuni.2018.07.010.

Zhou QQ, et al “Randomised placebo-controlled trial of dietary glutamine supplements for post infectious irritable bowel syndrome” Gut 2018; DOI:10.1136/gutjnl-2017-315136.

Avoidable food losses and associated production-phase greenhouse gas emissions arising from application of cosmetic standards to fresh fruit and vegetables in Europe and the UK. Journal of Cleaner Production, 201, 10 November 2018, 869-878, Stephen D. Porter, David S. Reay, Elizabeth Bomberg, Peter Higgins. https://doi.org/10.1016/j.jclepro.2018.08.079.

Lycopene

Lycopene Inhibits Disease Progression in Patients with Benign Prostate Hyperplasia. Silke Schwarz Ute C. Obermüller-Jevic Eva Hellmis Winfried Koch Günther JacobiHans-Konrad Biesalski. The Journal of Nutrition, Volume 138, Issue 1, 1 January 2008, Pages 49–53,https://doi.org/10.1093/jn/138.1.49

Rowles JL 3rd, Ranard KM, Smith JW, et al.: Increased dietary and circulating lycopene are associated with reduced prostate cancer risk: a systematic review and meta-analysis. Prostate Cancer Prostatic Dis 20 (4): 361-377, 2017.

Nrf2 signaling pathway: Pivotal roles in inflammation. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease, Vol 1863, 2, February 2017, 585-97.

Nutritional strategies to modulate inflammation and oxidative stress pathways via activation of the master antioxidant switch Nrf2. Ludmila F et al. , Biochimie (2013), http://dx.doi.org/10.1016/j.biochi.2013.04.012.

Holzapfel NP, Holzapfel BM, Champ S, Feldthusen J, Clements J, Hutmacher DW. The potential role of lycopene for the prevention and therapy of prostate cancer: from molecular mechanisms to clinical evidence. Int J Mol Sci. 2013;14(7):14620-14646.

Gann PH, Ma J, Giovannucci E, et al. Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysis. Cancer Res. 1999; 59(6):1225–1230.

Kirsh VA, Mayne ST, Peters U, et al. A prospective study of lycopene and tomato product intake and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2006; 15(1):92–98.

Dahan K, Fennal M, Kumar NB. Lycopene in the prevention of prostate cancer. J Soc Integr Oncol. 2008; 6(1):29–36.

Etminan M, Takkouche B, Caamano-Isorna F. The role of tomato products and lycopene in the prevention of prostate cancer: a meta-analysis of observational studies. Cancer Epidemiol Biomarkers Prev. 2004;13(3):340-345

Acupuncture
1) Coyne KS, Sexton CC, Vats V, Thompson C, Kopp ZS, Milsom I. National community prevalence of overactive bladder in the United States stratified by sex and age. Urology. 2011;77(5):1081–1087.

2) Irwin DE, Milsom I, Hunskaar S, et al. Population-based survey of urinary incontinence, overactive bladder and other lower urinary tract symptoms in five countries: results of the EPIC study. Eur Urol. 2006;50(6):1306–1315.

3) Stewart WF, Van Rooyen JB, Cundiff GW, et al. Prevalence and burden of overactive bladder in the United States. World J Urol. 2003;20(6):327–336.

4) Milsom I, Abrams P, Cardozo L, Roberts RG, Thüroff J, Wein AJ. How widespread are the symptoms of an overactive bladder and how are they managed? A population based prevalence study. BJU Int.
2001;87(9):760–766.

5) Coyne, KS, Sexton, CC, Thompson, C et al. (2009) The prevalence of lower urinary tract symptoms (LUTS) in the USA, the UK and Sweden: results from the Epidemiology of LUTS (EpiLUTS) study. BJU Int. 104 (3) 352-60.

6) National Institute for Health and Care Excellence (NICE) (­­­­­2015) Urinary Incontinence: The Management of Urinary Incontinence in Women. NICE Clinical Guideline 171. National Institute for Health and Care Excellence, London

7) Forde, J.C., Jaffe, E., Stone, B.V., Te, A.E., Espinosa, G. and Chughtai, B. (2016) The role of acupuncture in managing overactive bladder; a review of the literature. Int. Urogynecol. J. 27: 1645-1651.

8) Aydogmus, Y. et al. (2014) Acupuncture versus solifenacin for treatment of overactive bladder and its correlation with urine nerve growth factor levels: a randomised, placebo-controlled clinical trial. Urol Int. 93 (4) 437-43.

9) Yuan, Z. et al. (2015) Acupuncture for overactive bladder in female adult: a randomised controlled trial. World J. Urol. 33(9):1303-8

10) Kelleher, C.J., Burton, C., Khullar, V. and Cardozo, L.D. (1994) Acupuncture in the treatment of irritative bladder symptoms. Acupunct. Med. 12 (1) 9-12.

11) Moossdorff-Steinhauser, H.F.A. and Berghmans, B. (2013) Effects of Percutaneous Tibial Nerve Stimulation on Adult Patients with Overactive Bladder Syndrome: A Systematic Review. Neurourology and Urodynamics, 32: 206-214.

12) Wang, Y., Liu, B., Yu, J., Wu, J., Wang, J. and Liu, Z. (2013) Electroacupuncture for moderate and severe benign prostatic hyperplasia: a randomised controlled trial. Plos One, 8 (4) e59449.

13) Yu JS, Shen KH, Chen WC, Her JS, Hsieh CL (2011) Effects of Electroacupuncture on Benign Prostate Hyperplasia Patients with Lower Urinary Tract Symptoms: A Single-Blinded, Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine 20: 303198

14) Wang H et al (2012) Acupuncture of the sacral vertebrae suppresses bladder activity and bladder activity-related neurons in the brainstem micturition center. Neurosci Res 72(1):43–9

15) Paik, S-H., Han, S-R., Kwon, O.J. et al. (2010) Acupuncture for the treatment of urinary incontinence: a review of randomised controlled trials. Experimental and Therapeutic Medicine, 6 (3) 773-780.

BEN BROWN

  1. Jeffery IB, O’Toole PW, Ohman L, et al. An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota. Gut 2012;61: 997–1006.
  2. Rodiño-Janeiro BK, Vicario M, Alonso-Cotoner C, Pascua-García R, Santos J. A Review of Microbiota and Irritable Bowel Syndrome: Future in Therapies. Adv Ther. 2018 Mar;35(3):289-310.
  3. Ford AC, Quigley EM, Lacy BE, et al. Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis. Am J Gastroenterol. 2014 Oct;109(10):1547-61; quiz 1546, 1562.
  4. Sanders ME. Probiotics and microbiota composition. BMC Med. 2016 Jun 2;14(1):82. doi: 10.1186/s12916-016-0629-z.
  5. del Campo R, et al. Scarce evidence of yogurt lactic acid bacteria in human feces after daily yogurt consumption by healthy volunteers. Appl Environ Microbiol 2005;71:547–9.
  6. Cirstea M, Radisavljevic N, Finlay BB. Good Bug, Bad Bug: Breaking through Microbial Stereotypes. Cell Host Microbe. 2018 Jan 10;23(1):10-13.
  7. Derrien M, Belzer C, de Vos WM. Akkermansia muciniphila and its role in regulating host functions. Microb Pathog. 2017 May;106:171-181.
  8. Ottman N, Geerlings SY, Aalvink S, de Vos WM, Belzer C. Action and function of Akkermansia muciniphila in microbiome ecology, health and disease. Best Pract Res Clin Gastroenterol. 2017 Dec;31(6):637-642.
  9. Gómez-Gallego C, Pohl S, Salminen S, De Vos WM, Kneifel W. Akkermansia muciniphila: a novel functional microbe with probiotic properties. Benef Microbes. 2016 Sep;7(4):571-84.
  10. Heintz-Buschart A, Pandey U, Wicke T, Sixel-Döring F, Janzen A, Sittig-Wiegand E, Trenkwalder C, Oertel WH, Mollenhauer B, Wilmes P. The nasal and gut microbiome in Parkinson’s disease and idiopathic rapid eye movement sleep behavior disorder. Mov Disord. 2018 Jan;33(1):88-98.
  11. Berer K, Gerdes LA, Cekanaviciute E, Jia X, Xiao L, Xia Z, Liu C, Klotz L, Stauffer U, Baranzini SE, Kümpfel T, Hohlfeld R, Krishnamoorthy G, Wekerle H. Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10719-10724.
  12. Gerhardt S, Mohajeri MH. Changes of Colonic Bacterial Composition in Parkinson’s Disease and Other Neurodegenerative Diseases. Nutrients. 2018 Jun 1;10(6).
  13. Claesson MJ, Clooney AG, O’Toole PW. A clinician’s guide to microbiome analysis. Nat Rev Gastroenterol Hepatol. 2017 Oct;14(10):585-595.
  14. Langille MG, Zaneveld J, Caporaso JG, et al. Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences. Nat Biotechnol 2013;31(9):814–21.
  15. Gingras BA, Duncan SB, Scheuller NJ, Schreckenberber PC. Assessment of diagnostic accuracy of recently introduced DNA stool screening test. International Journal of Human Nutrition and Functional Medicine 2014: 2 (1); 1
  16. Pollock J, Glendinning L, Wisedchanwet T, Watson M. The Madness of Microbiome: Attempting To Find Consensus “Best Practice” for 16S Microbiome Studies. Appl Environ Microbiol. 2018 Mar 19;84(7).
  17. O’Toole PW, Flemer B. From Culture to High-Throughput Sequencing and Beyond: A Layperson’s Guide to the “Omics” and Diagnostic Potential of the Microbiome.Gastroenterol Clin North Am. 2017 Mar;46(1):9-17.
  18. Sommer MO. Advancing gut microbiome research using cultivation. Curr Opin Microbiol. 2015 Oct;27:127-32.
  19. Quigley EMM. Gut microbiome as a clinical tool in gastrointestinal disease management: are we there yet? Nat Rev Gastroenterol Hepatol. 2017 May;14(5):315-320.
  20. Sanders ME, Akkermans LM, Haller D, Hammerman C, Heimbach J, Hörmannsperger G, Huys G, Levy DD, Lutgendorff F, Mack D, Phothirath P, Solano-Aguilar G, Vaughan E. Safety assessment of probiotics for human use. Gut Microbes. 2010 May-Jun;1(3):164-85.
  21. Sheedy JR, Wettenhall RE, Scanlon D, Gooley PR, Lewis DP, McGregor N, Stapleton DI, Butt HL, DE Meirleir KL. Increased d-lactic Acid intestinal bacteria in patients with chronic fatigue syndrome. In Vivo. 2009 Jul-Aug;23(4):621-8.
  22. Munakata S, et al. A case of D-lactic acid encephalopathy associated with use of probiotics. Brain. Dev. 2010;32:691–694.
  23. Rao SSC, Rehman A, Yu S, Andino NM. Brain fogginess, gas and bloating: a link  between SIBO, probiotics and metabolic acidosis. Clin Transl Gastroenterol. 2018  Jun 19;9(6):162.
  24. Zheng Y, Lu Y, Wang J, et al. Probiotic properties of Lactobacillus strains isolated from Tibetan kefir grains. PLoS One. 2013;8(7):e69868.
  25. Han K, Bose S, Wang JH, et al. Contrasting effects of fresh and fermented kimchi consumption on gut microbiota composition and gene expression related to metabolic syndrome in obese Korean women. Mol Nutr Food Res. 2015;59(5):1004-1008.
  26. Raak C, Ostermann T, Boehm K, Molsberger F. Regular consumption of sauerkraut  and its effect on human health: a bibliometric analysis. Glob Adv Health Med. 2014 Nov;3(6):12-8.
  27. Villarreal-Soto SA, Beaufort S, Bouajila J, Souchard JP, Taillandier P. Understanding Kombucha Tea Fermentation: A Review. J Food Sci. 2018 Mar;83(3):580-588.
  28. Holbourn A, Hurdman J. Kombucha: is a cup of tea good for you? BMJ Case Rep. 2017 Dec 2;2017.
  29. SungHee Kole A, Jones HD, Christensen R, Gladstein J. A case of Kombucha tea toxicity. J Intensive Care Med. 2009 May-Jun;24(3):205-7.
  30. Srinivasan R, Smolinske S, Greenbaum D. Probable gastrointestinal toxicity of  Kombucha tea: is this beverage healthy or harmful? J Gen Intern Med. 1997 Oct;12(10):643-4.
  31. Egger GJ, Binns AF, Rossner SR. The emergence of “lifestyle medicine” as a structured approach for management of chronic disease. Med J Aust. 2009 Feb 2;190(3):143-5.
  32. Murtaza N, Ó Cuív P, Morrison M. Diet and the Microbiome. Gastroenterol Clin North Am. 2017 Mar;46(1):49-60.
  33. Prescott SL, Wegienka G, Logan AC, Katz DL. Dysbiotic drift and biopsychosocial medicine: how the microbiome links personal, public and planetary health. Biopsychosoc Med. 2018 May 3;12:7.

 

MICROBIOME

Duranti et al. Obesity and Microbiota and example of an intricate relationship, Genes & Nutrition (2017)

Foster et al., Stress & the gut-brain axis: Regulation by the microbiome, Neurobiology of Stress, (2017)

Harper et al., The Role of Bacteria, Probiotics and Diet in Irritable Bowel Syndrome, Foods (2018)

Lin et al., Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms, PLoS One (2012).

Healey et al., Interindividual variability in gut microbiota and host response to dietary interventions, Emerging Science, (2017).

Nagpal et al., Gut microbiome and aging: Physiological and mechanistic insights, Nutrition and Healthy Aging (2018).

O’Sullivan et al., Exercise and the microbiota, Gut Microbes, (2015).
Rajilić-Stojanović, Vos, The first 1000 cultured species of the human gastrointestinal microbiota, FEMS Microbiology Reviews, (2014).

Spector, et al., Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women, Scientific Report, (2017).

Toribio-Mateas, M., Harnessing the Power of Microbiome Assessment Tools as Part of Neuroprotective Nutrition and Lifestyle Medicine Interventions, Microorganisms, (2018).

Valdes et al., Role of the gut microbiota in nutrition and health, BMJ, (2018).

PROBIOTICS RESEARCH

Catherine R. Lammert, Elizabeth L. Frost, Ashley C. Bolte, Matt J. Paysour, Mariah E. Shaw, Calli E. Bellinger, Thaddeus K. Weigel, Eli R. Zunder, John R. Lukens. Cutting Edge: Critical Roles for Microbiota-Mediated Regulation of the Immune System in a Prenatal Immune Activation Model of AutismThe Journal of Immunology, 2018; ji1701755 DOI: 10.4049/jimmunol.1701755.

Anna G. Nilsson, Daniel Sundh, Fredrik Bäckhed, Mattias Lorentzon. Lactobacillus reuteri reduces bone loss in older women with low bone mineral density – a randomized, placebo-controlled, double-blind, clinical trialJournal of Internal Medicine, 2018; DOI: 10.1111/joim.12805

Rick Kapur, Michael Kim, Johan Rebetz, Björn Hallström, Jonas T. Björkman, Alisa Takabe-French, Noel Kim, Jonathan Liu, Shanjeevan Shanmugabhavananthan, Stefan Milosevic, Mark J. McVey, Edwin R. Speck, John W. Semple. Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injuryBlood Advances, 2018; 2 (13): 1651 DOI: 10.1182/bloodadvances.2018018903

Annabelle M. Watts, Amanda J. Cox, Peter K. Smith, Isolde Besseling-van der Vaart, Allan W. Cripps, and Nicholas P. West. The Journal of Alternative and Complementary Medicine. Aug 2018, ahead of print: http://doi.org/10.1089/acm.2017.0342.

SIBO
Satish S. C. Rao, Abdul Rehman, Siegfried Yu, Nicole Martinez de Andino. Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosisClinical and Translational Gastroenterology, 2018; 9 (6) DOI: 10.1038/s41424-018-0030-7.

Am J Gastroenterol. 2003 Feb;98 (2):412-9. Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome. a double-blind, randomized, placebo-controlled study. Pimentel M, Chow EJ, Lin HC.

Chedid V, Dhalla S, Clarke JO, et al. Herbal therapy is equivalent to rifaximin for the treatment of small intestinal bacterial overgrowth. Global Adv Health Med. 2014;3(3):16-24.

RESEARCH
Cindy W Leung, Teresa T Fung, Claire T McEvoy, Jue Lin, Elissa S Epel. Diet Quality Indices and Leukocyte Telomere Length among Healthy US Adults: Data from the National Health and Nutrition Examination Surveys (NHANES) 1999-2002. American Journal of Epidemiology, 2018; DOI: 10.1093/aje/kwy124.

Pre-Exercise Breakfast Ingestion versus Extended Overnight Fasting Increases Postprandial Glucose Flux after Exercise in Healthy Men. American Journal of Physiology-Endocrinology and Metabolism, 2018; DOI: 10.1152/ajpendo.00163.2018

The relationship between adiposity and cognitive function in a large community-dwelling population: data from the Trinity Ulster Department of Agriculture (TUDA) ageing cohort study. British Journal of Nutrition, 2018: https://doi.org/10.1017/S0007114518001848.

Dementia
Kennedy KM, Rodrigue KM, Devous MD Sr, Hebrank AC, Bischof GN, Park DC. Effects of beta-amyloid accumulation on neural function during encoding across the adult lifespan. Neuroimage. 2012 Aug 1;62(1):1-8. Epub 2012 May 1 PubMed.

Bischof GN, Rodrigue KM, Kennedy KM, Devous MD Sr, Park DC. Amyloid deposition in younger adults is linked to episodic memory performance. Neurology. 2016 Dec 13;87(24):2562-2566. Epub 2016 Nov 11 PubMed.

Farrell ME, Kennedy KM, Rodrigue KM, Wig G, Bischof GN, Rieck JR, Chen X, Festini SB, Devous MD Sr, Park DC.Association of Longitudinal Cognitive Decline With Amyloid Burden in Middle-aged and Older Adults: Evidence for a Dose-Response Relationship. JAMA Neurol. 2017 Jul 1;74(7):830-838. PubMed.

Amariglio RE, Becker JA, Carmasin J, Wadsworth LP, Lorius N, Sullivan C, Maye JE, Gidicsin C, Pepin LC, Sperling RA, Johnson KA, Rentz DM. Subjective cognitive complaints and amyloid burden in cognitively normal older individuals. Neuropsychologia. 2012 Oct;50(12):2880-6. PubMed.

Phylogeny-corrected identification of microbial gene families relevant to human gut colonization. PLOS Computational Biology, August 9, 2018: https://doi.org/10.1371/journal.pcbi.1006242

A Phenome-Wide Association Study Uncovers a Role for Autoimmunity in the Development of Chronic Obstructive Pulmonary Disease. American Journal of Respiratory Cell and Molecular Biology, 2018; 58 (6): 777 DOI: 10.1165/rcmb.2017-0409LE

Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for β Cell Recovery. Cell Metabolism, 2018,

Published: August 02: https://doi.org/10.1016/j.cmet.2018.07.003.

August 2018

WELCOME

Complementary Medicine, Refusal of Conventional Cancer Therapy, and Survival Among Patients With Curable Cancers

JAMA Oncol. Published online July 19, 2018. doi:10.1001/jamaoncol.2018.2487

Am J Orthop (Belle Mead NJ). 2011 May;40(5):E92-5.

Underreporting of complementary and alternative medicine use among arthritis patients in an orthopedic clinic.

NEWS

Jahnabi Roy et al. Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides, Journal of Medicinal Chemistry (2018). DOI: 10.1021/acs.jmedchem.8b00243

Gut Microbiota Composition is Related to Cardiorespiratory Fitness in Healthy Young AdultsInternational Journal of Sport Nutrition and Exercise Metabolism, 2018; 1 DOI: 10.1123/ijsnem.2018-0024

Voluntary fortification is ineffective to maintain the vitamin B12 and folate status of older Irish adults: evidence from the Irish Longitudinal Study on Ageing (TILDA)British Journal of Nutrition, 2018; 120 (01): 111 DOI: 10.1017/S0007114518001356.

Continuity of care with doctors—a matter of life and death? A systematic review of continuity of care and mortality. BMJ Open, 8:6. http://dx.doi.org/10.1136/bmjopen-2017-021161.

Long-Term Acupuncture Therapy for Low-Income Older Adults with Multimorbidity: A Qualitative Study of Patient Perceptions.

J Altern Complement Med. 2018 Feb;24(2):161-167. doi: 10.1089/acm.2017.0239. Epub 2017 Oct 23.

SIMON MILLS

Bower MR, Aiyer HS, Li Y, Martin RCG (2010) Chemoprotective effects of curcumin in esophageal epithelial cells exposed to bile acids. World J Gastroenterol vol 16, no 33, pp 4152-4158

Camilleri M (2015) Bile Acid Diarrhea: Prevalence, Pathogenesis, and Therapy. Gut Liver. 2015 May; 9(3): 332–339

Camilleri M (2014) Physiological underpinnings of irritable bowel syndrome: neurohormonal mechanisms. J Physiol. vol 592, Pt 14, pp 2967–2980

Cavaleri, F (2018) Presenting a New Standard Drug Model for Turmeric and Its Prized Extract, Curcumin. International Journal of Inflammation. Article ID 5023429, 18 pages.

Cho JA. Park E (2015) Curcumin utilizes the anti-inflammatory response pathway to protect the intestine against bacterial invasion. Nutrition Research and Practice vol 9, no 2, pp 117-122

Dey N, Wagner VE, Blanton LV (2015) Regulators of gut motility revealed by a gnotobiotic model of diet-microbiome interactions related to traveling. Cell vol 163, no 1, pp 95-107

Ghosh SS, Gehr TWB, Ghosh S (2014) Curcumin and Chronic Kidney Disease (CKD): Major Mode of Action through Stimulating Endogenous Intestinal Alkaline Phosphatase. Molecules vol 19, 20139-20156; doi:10.3390/molecules191220139

Gilani AH, Shah AJ, Ghayur MN, Majeed K (2005) Pharmacological basis for the use of turmeric in gastrointestinal and respiratory disorders. Life Sciences vol 76 pp 3089–3105

Hucklenbroich J Klein R, Neumaier B et al (2014). Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo. Stem Cell Research & Therapy vol 5, p 100.  http://stemcellres.com/content/5/4/100

Kashyap P (2015) Eat your curry Cell Host Microbe. vol 18, no 4, pp 385-387

Lopresti, A (2018) The Problem of Curcumin and Its Bioavailability: Could Its Gastrointestinal Influence Contribute to Its Overall Health-Enhancing Effects? Adv Nutr vol 9, pp 41–50

Marciani L, Cox EF, Hoad CL et al (2013). Effects of various food ingredients on gall bladder emptying. Eur J Clin Nutr. vol 11, pp 1182-7.

Martelli L, Ragazzi E, Di Mario F et al (2007) Potential role for the vanilloid receptor TRPV1 in the therapeutic effect of curcumin in dinitrobenzene sulphonic acid-induced colitis in mice. Neurogastroenterol Motil vol 19, pp 668–674

McFadden RM, Larmonier CB, Shehab KW, et al. (2015) The role of curcumin in modulating colonic microbiota during colitis and colon cancer prevention. Inflamm Bowel Dis. Vol 21, pp 2483–94

Orellana-Paucar AM, Afrikanova T, Thomas J, et al: Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy. PLoS One 2013, 8:e81634

Park SYa, Jin ML, Kim YH et al (2012) Anti-inflammatory effects of aromatic-turmerone through blocking of NF-κB, JNK, and p38 MAPK signaling pathways in amyloid β-stimulated microglia. International Immunopharmacology vol 14, pp 13–20

Park SYb, Kim YH, Kim Y, Lee S-J (2012) Aromatic-turmerone’s anti-inflammatory effects in microglial cells are mediated by protein kinase A and heme oxygenase-1 signaling. Neurochemistry International vol 61 pp 767–777

Patcharatrakul P, Gonlachanvit S (2016) Chili Peppers, Curcumins, and Prebiotics in Gastrointestinal Health and Disease. Curr Gastroenterol Rep vol 18, no 19

Pole, S (2103) Ayurvedic Medicine: the principals of traditional practice. Churchill Livingstone, Elsevier, London and Philadelphia. pp 282-83

Rasyid A, Rahman AR, Jaalam K, Lelo A (2002) Effect of different curcumin dosages on human gall bladder. Asia Pac J Clin Nutr. vol 11, no 4, pp 314-8

Schneider A, Hossain I, Van der Molen J, Nicol K (2017) Comparison of remicade to curcumin for the treatment of Crohn’s disease: A systematic review. Complementary Therapies in Medicine vol 33, pp 32-38

Shen L, Ji HF. (2012) The pharmacology of curcumin: is it the degradation products? Trends Mol Med. vol 18, no 3, pp 138-44

Shen L, Liu L, Ji HF. (2017) Regulative effects of curcumin spice administration on gut microbiota and its pharmacological implications. Food Nutr Res. vol 61, no 1, 1361780

Shimouchi A, Nose K, Takaoka M, et al. (2009) Effect of dietary turmeric on breath hydrogen. Dig Dis Sci. vol 54, no 8, pp 1725-9

Shin A, Camilleri M, Vijayvargiya P et al (2013) Bowel Functions, Fecal Unconjugated Primary and Secondary Bile Acids, and Colonic Transit in Patients with Irritable Bowel Syndrome. Clin Gastroenterol Hepatol. vol 11, no 10, pp 1270–1275

Sreedhar R, Arumugam S, Thandavarayan RA, et al (2016) Curcumin as a therapeutic agent in the chemoprevention of inflammatory bowel disease. Drug Discovery Today vol 21, no 5, pp 843-849

Wang Y, Wang L, Zhu X et al (2016) Choleretic Activity of Turmeric and its Active Ingredients. Journal of Food Science vol 81, No 7, pp 1800-06

Yu Y, Wu S, Li J et al (2015) The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signalling. Metab Brain Dis vol 30, pp 47–55

Yue G G-L, Kwok H-F, Julia Kin-Ming Lee J K-M, Jiang L (2015) Novel anti-angiogenic effects of aromatic turmerone, essential oil isolated from spice turmeric. Journal of Functional Foods vol 15, pp 243–253

BREDESEN

Reversal of cognitive decline: A novel therapeutic program

Dale E. Bredesen. Aging (Albany NY). 2014 Sep; 6(9): 707–717.

Published online 2014 Sep 27. doi:  10.18632/aging.100690.

Brain training: https://www.brainhq.com.

Dr Ritchie Shoemaker (author of Surviving Mold): https://www.survivingmold.com.

Cyrex 2 and 3: available in the UK from Regenerus: http://regeneruslabs.com/page/cyrex.

HEART HEALTH
Joonseok Kim, Jaehyoung Choi, Soo Young Kwon, John W. McEvoy, Michael J. Blaha, Roger S. Blumenthal, Eliseo Guallar, Di Zhao, Erin D. Michos. Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease. Circulation: Cardiovascular Quality and Outcomes, 2018; 11 (7): e004224 DOI: 10.1161/CIRCOUTCOMES.117.004224

Supplemental Vitamins and Minerals for CVD Prevention and Treatment. Journal of the American College of Cardiology, 2018; 71 (22): 2570 DOI: 10.1016/j.jacc.2018.04.020

Roberto Sansone, Ana Rodriguez-Mateos, Jan Heuel, David Falk, Dominik Schuler, Rabea Wagstaff, Gunter G. C. Kuhnle, Jeremy P. E. Spencer, Hagen Schroeter, Marc W. Merx, Malte Kelm, Christian Heiss. Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study. British Journal of Nutrition, 2015; 1 DOI: 10.1017/S0007114515002822.

Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis. BMJ Open Heart, 2018, 5:1. http://dx.doi.org/10.1136/openhrt-2017-000668.

25-Hydroxyvitamin D Levels and the Risk of Mortality in the General PopulationArchives of Internal Medicine, 2008; 168 (15): 1629 DOI: 10.1001/archinte.168.15.1629

Zwakenberg SR, den Braver NR, Engelen AIP, Feskens, EJM, Vermeer C, Boer JMA, Verschuren WMM, van der Schouw YT, Beulens JWJ. Vitamin K intake and all-cause and cause specific mortality. Clinical Nutrition. 2016 Aug 30. Pii: S0261-5614(16)30216-3. 15-20. DOI: 10.1016/j.clnu.2016.08.017.

Knapen MH et al, Braam LAJL, Drummen NE, Bekers O, Hoeks APG, Vermeer C. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women: double-blind randomised clinical trial. Thrombosis and Haemostasis. 2015 113 5: 1135-1144. doi: 10.1160/TH14-08-0675.

Br J Nutr. 2012 May;107(10):1505-13. doi: 10.1017/S0007114511004703. Epub 2011 Nov 9. Cholesterol-lowering efficacy of a microencapsulated bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 yoghurt formulation in hypercholesterolaemic adults.

Eur J Clin Nutr. 2012 Nov;66(11):1234-41. doi: 10.1038/ejcn.2012.126. Epub 2012 Sep 19. Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteri NCIMB 30242: a randomized controlled trial.

Exp Diabetes Res. 2012;2012:902917. doi: 10.1155/2012/902917. Epub 2012 May 3.

Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases.

J Clin Endocrinol Metab. 2013 Jul;98(7):2944-51. doi: 10.1210/jc.2012-4262. Epub 2013 Apr 22. Oral supplementation with probiotic L. reuteri NCIMB 30242 increases mean circulating 25-hydroxyvitamin D: a post hoc analysis of a randomized controlled trial

Ann N Y Acad Sci. 2011 Jan;1215:22-33. doi: 10.1111/j.1749-6632.2010.05843.x.

Resveratrol in cardiovascular health and disease.

Cardiovasc Drug Rev. 2004 Fall;22(3):169-88.

Cardiovascular protective effects of resveratrol.

 

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. Ann Intern Med 2009;151(4):264-269.

DOI: 10.7326/0003-4819-151-4-200908180-00135

IN PRACTICE

Emma Lane on Blastocystis hominis: full article with references at https://www.integrativehealth.co.uk/parasites-and-ibs.

LAB TEST

  1. Gulati, P., & Yeo, G. S. H. (2013). The biology of FTO: from nucleic acid demethylase to amino acid sensor. Diabetologia56(10), 2113–2121. http://doi.org/10.1007/s00125-013-2999-5
  2. Kilpeläinen, T. O., Qi, L., Brage, S., Sharp, S. J., Sonestedt, E., Demerath, E., … Loos, R. J. F. (2011). Physical Activity Attenuates the Influence of FTOVariants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children. PLoS Medicine8(11), e1001116. http://doi.org/10.1371/journal.pmed.1001116
  3. Huang, T., Qi, Q., Li, Y., Hu, F. B., Bray, G. A., Sacks, F. M., … Qi, L. (2014). FTOgenotype, dietary protein, and change in appetite: the Preventing Overweight Using Novel Dietary Strategies trial. The American Journal of Clinical Nutrition99(5), 1126–1130. http://doi.org/10.3945/ajcn.113.082164
  4. Yang, X., Yin, L., Li, T., & Chen, Z. (2014). Green tea extracts reduce adipogenesis by decreasing expression of transcription factors C/EBPα and PPARγ. International Journal of Clinical and Experimental Medicine7(12), 4906–4914.
  5. Wei Ren, Jianjin Guo, Feng Jiang, et al., 2014 “CCAAT/Enhancer-Binding Protein αIs a Crucial Regulator of Human Fat Mass and Obesity Associated Gene Transcription and Expression,” BioMed Research International, vol. 2014, https://doi.org/10.1155/2014/406909.
  6. Loos, R. J. F., Lindgren, C. M., Li, S., Wheeler, E., Zhao, J. H., Prokopenko, I., … Mohlke, K. L. (2008). Common variants near MC4Rare associated with fat mass, weight and risk of obesity. Nature Genetics40(6), 768–775. http://doi.org/10.1038/ng.140
  7. Goni, L., García-Granero, M., Milagro, F. I., Cuervo, M., & Martínez, J. A. (2018). Phenotype and genotype predictors of BMI variability among European adults. Nutrition & Diabetes8, 27. http://doi.org/10.1038/s41387-018-0041-1
  8. Tao, Y.-X. (2010). The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology. Endocrine Reviews31(4), 506–543. http://doi.org/10.1210/er.2009-0037
  9. Klaauw, A. A., Keogh, J. M., Henning, E., Stephenson, C., Kelway, S., Trowse, V. M., . . . Farooqi, I. S. (2016). Divergent effects of central melanocortin signalling on fat and sucrose preference in humans. Nature Communications, 7, 13055. doi:10.1038/ncomms13055
  10. Meal Frequencies Modify the Effect of Common Genetic Variants on Body Mass Index in Adolescents of the Northern Finland Birth Cohort 1986
    Jääskeläinen A, Schwab U, Kolehmainen M, Kaakinen M, Savolainen MJ, et al. (2013) https://dx.doi.org/10.1371%2Fjournal.pone.0073802
  11. McDaniel, F. K., Molden, B. M., Mohammad, S., Baldini, G., McPike, L., Narducci, P., … Baldini, G. (2012). Constitutive Cholesterol-dependent Endocytosis of Melanocortin-4 Receptor (MC4R) Is Essential to Maintain Receptor Responsiveness to α-Melanocyte-stimulating Hormone (α-MSH). The Journal of Biological Chemistry287(26), 21873–21890. http://doi.org/10.1074/jbc.M112.346890
  12. Common Genetic Variation near MC4R Has a Sex-Specific Impact on Human Brain Structure and Eating Behavior
    Horstmann A, Kovacs P, Kabisch S, Boettcher Y, Schloegl H, et al. (2013) Common Genetic Variation near MC4R Has a Sex-Specific Impact on Human Brain Structure and Eating Behavior.PLOS ONE 8(9): e73802. https://doi.org/10.1371/journal.pone.0073802

 

Fecal Gluten Peptides Reveal Limitations of Serological Tests and Food Questionnaires for Monitoring Gluten-Free Diet in Celiac Disease Patients

The American Journal of Gastroenterology, volume111,1456–65 (2016).

Comparison of Clinical Methods with the Faecal Gluten Immunogenic Peptide to Assess Gluten Intake in Coeliac Disease. Gerasimidis, Konstantinos et al.

Journal of Pediatric Gastroenterology and Nutrition: June 18, 2018 – Volume Publish Ahead of Print. doi: 10.1097/MPG.0000000000002062.

Curr Med Res Opin. 2012 Nov;28(11):1819-30. doi: 10.1185/03007995.2012.742878.

Coronary risk assessment among intermediate risk patients using a clinical and biomarker based algorithm developed and validated in two population cohorts.

RESEARCH
Amaia Arranz-Otaegui, Lara Gonzalez Carretero, Monica N. Ramsey, Dorian Q. Fuller, Tobias Richter. Archaeobotanical evidence reveals the origins of bread 14,400 years ago in northeastern JordanProceedings of the National Academy of Sciences, 2018; 201801071 DOI: 10.1073/pnas.1801071115.

Eur J Clin Nutr. 2003 Oct;57(10):1254-61.

Lower glucose-dependent insulinotropic polypeptide (GIP) response but similar glucagon-like peptide 1 (GLP-1), glycaemic, and insulinaemic response to ancient wheat compared to modern wheat depends on processing.

J Gen Intern Med. 2018 Jul;33(7):1131-1138. doi: 10.1007/s11606-018-4377-y. Epub 2018 Mar 5.

Underdiagnosis of Dementia: an Observational Study of Patterns in Diagnosis and Awareness in US Older Adults

Occult blood in faeces is associated with all-cause and non-colorectal cancer mortalityGut, 2018; gutjnl-2018-316483 DOI: 10.1136/gutjnl-2018-316483

Uri Ladabaum. Occult blood in faeces: a window into health beyond the colorectum? Gut, 2018; gutjnl-2018-316762 DOI: 10.1136/gutjnl-2018-316762

Using citizen science to describe the prevalence and distribution of tick bite and exposure to tick-borne diseases in the United StatesPLOS ONE, 2018; 13 (7): e0199644 DOI: 10.1371/journal.pone.0199644

Dietary flavonoids and the prevalence and 15-y incidence of age-related macular degeneration. American Journal of Clinical Nutrition, 2018 DOI: 10.1093/ajcn/nqy114

Effects of an Antioxidant-enriched Multivitamin in Cystic Fibrosis: Randomized, Controlled, Multicenter Trial. American Journal of Respiratory and Critical Care Medicine, 2018; DOI: 10.1164/rccm.201801-0105OC

July 2018

NEWS

Ishaque SM, Khosruzzaman SM, Ahmed DS, Sah MP. A randomized placebo-controlled clinical trial of a multi-strain probiotic formulation (Bio-Kult®) in the management of diarrhea-predominant irritable bowel syndrome. BMC
Gastroenterol 2018;18(1):71.

Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts. JNCI: Journal of the National Cancer Institute, 2018; DOI: 10.1093/jnci/djy087

Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: A pilot study. Nutrition and Healthy Aging, 2018; 4 (4): 345 DOI: 10.3233/NHA-170036

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112. van der Valk ES, Savas M, van Rossum EFC. Stress and Obesity: Are There More Susceptible Individuals? Curr Obes Rep. 2018 Jun;7(2):193-203.
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117. García-Toro M, Vicens-Pons E, Gili M, Roca M, Serrano-Ripoll MJ, Vives M, Leiva A, Yáñez AM, Bennasar-Veny M, Oliván-Blázquez B. Obesity, metabolic syndrome and Mediterranean diet: Impact on depression outcome. J Affect Disord. 2016 Apr;194:105-8.
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121. Barbadoro P, Annino I, Ponzio E, Romanelli RM, D’Errico MM, Prospero E, Minelli A. Fish oil supplementation reduces cortisol basal levels and perceived stress: a randomized, placebo-controlled trial in abstinent alcoholics. Mol Nutr Food Res. 2013 Jun;57(6):1110-4.
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124. Shishtar E, Sievenpiper JL, Djedovic V, Cozma AI, Ha V, Jayalath VH, Jenkins DJ, Meija SB, de Souza RJ, Jovanovski E, Vuksan V. The effect of ginseng (the genus panax) on glycemic control: a systematic review and meta-analysis of randomized controlled clinical trials. PLoS One. 2014 Sep 29;9(9):e107391.
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LEARNING ZONE
affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study. Journal of Affective Disorders, May 2018, 232, 349–357.

KERRY BONE

1. Akhondzaheh S, Tahmacebi-Pour N, Noorbala AA et al. Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial. Phytother Res 2005; 19(2): 148-151.
2. Moshiri E, Basti AA, Noorbala AA et al. Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: a double-blind, randomized and placebo-controlled trial. Phytomedicine 2006; 13(9-10): 607-611.
3. Akhondzadeh S, Fallah-Pour H, Afkham K et al. Comparison of Crocus sativus L and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial [ISRCTN45683816]. BMC Complement Altern Med 2004; 4: 12.
4. Noorbala AA, Akhondzadeh S, Tahmacebi-Pour N et al. Hydro-alcoholic extract of Crocus sativus L versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial. J Ethnopharmacol 2005; 97(2): 281-284
5. Akhondzadeh Basti A, Moshiri E, Noorbala AA et al. Comparison of petal of Crocus sativus L and fluoxetine in the treatment of depressed outpatients: a pilot double-blind randomized trial. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31(2): 439-442
6. Modabbernia A, Sohrabi H, Nasehi AA et al. Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial. Psychopharmacology (Berl) 2012; 223(4): 381-388
7. Kashani L, Raisi F, Saroukhani S et al. Saffron for treatment of fluoxetine-induced sexual dysfunction in women: randomized double-blind placebo-controlled study. Hum Psychopharmacol 2012 [Epub ahead of print]
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9. Berger F, Hensel A, Nieber K. Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices. Neuroscience 2011; 180: 238-247
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11. Sadeghnia HR, Cortez MA, Liu D et al. Antiabsence effects of safranal in acute experimental seizure models: EEG and autoradiography. J Pharm Pharm Sci 2008; 11(3): 1-14.

12. Akhondzadeh S, Shafiee Sabet M, Harirchian MH et al. A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer’s disease. Psychopharmacology (Berl) 2010; 207(4): 637-643
13. Akhondzadeh S, Sabet MS, Harirchian MH et al. Saffron in the treatment of patients with mild to moderate Alzheimer’s disease: a 16-week, randomized and placebo- controlled trial. J Clin Pharm Ther 2010; 35(5): 581-588
14. Agha-Hosseini M, Kashani L, Aleyaseen A et al. Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo- controlled trial. BJOG 2008; 115(4):
515-519

15. Nahid K, Fariborz M, Ataolah G et al. The effect of an Iranian herbal drug on primary dysmenorrhea: a clinical controlled trial. J Midwifery Womens Health 2009; 54(5):
401-404.
16. Gout B, Bourges C, Paineau-Dubreuil S. Satiereal, a Crocus sativus L extract, reduces snacking and increases satiety in a randomized placebo-controlled study
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17. Falsini B, Piccardi M, Minnella A et al. Influence of saffron supplementation on retinal flicker sensitivity in early age-related macular degeneration. Invest Ophthalmol Vis Sci 2010; 51(12): 6118-6124
18. Professor Silvia Bisti. Researchers strike gold – saffron found to help vision loss in elderly. The University of Sydney News, 5 February 2010. http://sydney.edu. au/news/84.html?newsstoryid=4452. Accessed January 2013.
19. Piccardi M, Marangoni D, Minnella AM et al. A longitudinal follow-up study of saffron supplementation in early age-related macular degeneration: sustained benefits to central retinal function. Evid Based Complement Alternat Med 2012; 2012: 429124

NEW RELEASES

Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces. Nature Immunology, 2016; DOI: 10.1038/ni.3345

GUT HEALTH

Miguel’s food challenge:
Pdf: https://www.dropbox.com/s/s9ngpw95o5r3kwb/50%20foods.pdf?dl=0
Powerpoint: https://www.dropbox.com/s/wfnl4hmwcx820qp/50%20foods.pptx?dl=0

Harnessing the Power of Microbiome Assessment Tools as Part of Neuroprotective Nutrition and Lifestyle Medicine Interventions
by Miguel Toribio-Mateas. Microorganisms 2018, 6(2), 35; https://doi.org/10.3390/microorganisms6020035.

American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems. 2018 May 15;3(3). pii: e00031-18. doi: 10.1128/mSystems.00031-18. eCollection 2018 May-Jun.

Martin, C. M. and Felix-Bortolotti, M. (2010) ‘W(h)ither complexity? The emperor’s new toolkit? Or elucidating the evolution of health systems knowledge?’, J Eval Clin
Pract, 16(3), pp. 415-20.

Daniel McDonald et al. American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems, 2018; 3 (3): e00031-18 DOI: 10.1128/mSystems.00031-18

Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth.
Probiotics Antimicrob Proteins. 2018 Mar 5. doi: 10.1007/s12602-018-9401-3. [Epub ahead of print]

RESEARCH

CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system—New mode of action for caffeine. PLOS Biology, 2018; 16 (6): e2004408 DOI: 10.1371/journal.pbio.2004408

Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus. Neuron, 2018; DOI: 10.1016/j.neuron.2018.05.023

June 2018

NEWS

Mediterranean diet and 3-year Alzheimer brain biomarker changes in middle-aged adults. Neurology. Online April 13, 2018, DOI: https://doi.org/10.1212/WNL.0000000000005527.

Lifestyle and vascular risk effects on MRI-based biomarkers of Alzheimer’s disease: a cross-sectional study of middle-aged adults from the broader New York City area. BMJ Open. 2018 Mar 23;8(3):e019362. doi: 10.1136/bmjopen-2017-019362.

Counting the Cost: http://www.meassociation.org.uk/wp-content/uploads/2020Health-Counting-the-Cost-Sept-2017.pdf.

Bernie Sanders opioid bill: https://www.sanders.senate.gov/newsroom/recent-business/sanders-introduces-legislation-to-hold-opioid-makers-accountable-.

BEN BROWN – IBD interventions

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INFLAMMATION

1. ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury. The American Journal of Gastroenterology, 2014; DOI: 10.1038/ajg.2014.131.
Bonkovsky also quoted in “When Green Tea Is a Bad Thing”, by Charlotte Hilton Andersen, SHAPE: https://www.shape.com/blogs/shape-your-life/when-green-tea-bad-thing.
2. Determination of Catechin and Epicatechin Content in Chocolates by High-Performance Liquid Chromatography. Int Sch Res Notices. 2014; 2014: 628196. Published online 2014 Oct 28. doi:  10.1155/2014/628196.

  1. Green Tea Catechins and Cardiovascular Health: An Update. Curr Med Chem. 2008; 15(18): 1840–1850. Pon Velayutham, Anandh Babu, and Dongmin Liu.
  2. Suppressive Effects of Tea Catechins on Breast Cancer. Nutrients. 2016 Aug; 8(8): 458. Published online 2016 Jul 28. doi:  10.3390/nu8080458
  3. Green Tea Polyphenols Stimulate Mitochondrial Biogenesis and Improve Renal Function after Chronic Cyclosporin A Treatment in Rats. PLoS One. 2013; 8(6): e65029.

Published online 2013 Jun 3. doi:  10.1371/journal.pone.0065029

Blueberry Supplementation Influences the Gut Microbiota, Inflammation, and Insulin Resistance in High-Fat-Diet-Fed Rats. J Nutr. 2018 Feb 1;148(2):209-219. doi: 10.1093/jn/nxx027.

Diet-driven microbiota dysbiosis is associated with vagal remodeling and obesity. Physiology & Behavior, 2017; 173: 305 DOI: 10.1016/j.physbeh.2017.02.027

Oral NaHCO3 Activates a Splenic Anti-Inflammatory Pathway: Evidence That Cholinergic Signals Are Transmitted via Mesothelial Cells. The Journal of Immunology, 2018; ji1701605 DOI: 10.4049/jimmunol.1701605

Calanus
Wax Esters from the Marine Copepod Calanus finmarchicus Reduce Diet-Induced Obesity and Obesity-Related Metabolic Disorders in Mice. J Nutr, 2013, doi: 10.3945/jn.113.182501.
Oil from the marine zooplankton Calanus finmarchicus improves the cardiometabolic phenotype of diet-induced obese mice. British Journal of Nutrition 2013, 110 (12): 2186-93.

Wax Esters from the Marine Copepod Calanus finmarchicus Reduce Diet-Induced Obesity and Obesity-Related Metabolic Disorders in Mice. J Nutr 2014, 144 (2): 164-169.

Extract from the Marine Copepod Calanus finmarchicus Attenuates Atherogenesis in Female Apolipoprotein E-Deficient Mice. J Nutr 2012, 142: 508-512.
Dietary and pharmacological anti-obesogenic treatments improve myocardial metabolism in diet-induced obese mice. Poster presented at 2017 Annual Scientific Sessions, Society for Heart and Vascular Metabolism. P2.11.

MUSHROOMS

  1. Mushrooms: A rich source of the antioxidants ergothioneine and glutathione. Michael D. Kalaras, John P. Richie, Ana Calcagnotto, Robert B. Beelman.  Food Chemistry, 2017; 233: 429 DOI: 10.1016/j.foodchem.2017.04.109
  2. The Complexity of Fungal β-Glucan in Health and Disease: Effects on the Mononuclear Phagocyte System. Camilli G, Tabouret G, Quintin J. Front Immunol.2018 Apr 16;9:673. doi: 10.3389/fimmu.2018.00673. eCollection 2018.
  3. Anti-inflammatory properties of the medicinal mushroom Cordyceps militaris might be related to its linear (1→3)-β-D-glucan. PLoS One.2014 Oct 17;9(10):e110266. doi: 10.1371/journal.pone.0110266. eCollection 2014.
    4. β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance. Cell, 2016; 167 (5): 1354 DOI: 10.1016/j.cell.2016.09.034
  4. http://www.superbetaglucan.com.
  5. Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation. J Diet Suppl.2016 Jul 13:1-13. [Epub ahead of print]
  6. Edible and Medicinal Mushrooms: Emerging Brain Food for the Mitigation of Neurodegenerative Diseases. Journal of Medicinal FoodVOL. 20, NO. 1 |

Published Online: 1 Jan 2017 https://doi.org/10.1089/jmf.2016.3740

  1. Article online at MRL’s website: https://www.mycologyresearch.com/articles/link-between-herpes-simplex-virus-and-alzheimers-disease-potential-role-of-mushroom-nutrition-supplementation-in-prevention.

RESEARCH
Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging. Cell Stem Cell, 2018; 22 (5): 769 DOI: 10.1016/j.stem.2018.04.001.

Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells. Cell Metab. 2016 Apr 12;23(4):663-74. doi: 10.1016/j.cmet.2016.03.001. Epub 2016 Mar 31.

Natural polyphenols as sirtuin 6 modulators. Scientific Reports, 2018; 8 (1) DOI: 10.1038/s41598-018-22388-5.

Inactive Matrix Gla Protein, Arterial Stiffness, and Endothelial Function in African American Hemodialysis Patients. American Journal of Hypertension, 2018; 31 (6): 735 DOI: 10.1093/ajh/hpy049.

Effect of a high-egg diet on cardiometabolic risk factors in people with type 2 diabetes: the Diabetes and Egg (DIABEGG) Study—randomized weight-loss and follow-up phase.  American J of Clinical Nutrition, 2018; DOI: 10.1093/ajcn/nqy048

Microglial control of astrocytes in response to microbial metabolites. Nature, 2018; DOI: 10.1038/s41586-018-0119-x

The mycobiome: Role in health and disease, and as a potential probiotic target in gastrointestinal disease. Dig Liver Dis. 2017 Nov;49(11):1171-1176. doi: 10.1016/j.dld.2017.08.025. Epub 2017 Oct 4.

Vitamin D Switches BAF Complexes to Protect β Cells. Cell, 2018; DOI: 10.1016/j.cell.2018.04.013.

May 2018

NEWS
JAMA Intern Med. 2018 Jan 1;178(1):17-26. doi: 10.1001/jamainternmed.2017.5038.

Association Between Pesticide Residue Intake From Consumption of Fruits and Vegetables and Pregnancy Outcomes Among Women Undergoing Infertility Treatment With Assisted Reproductive Technology.

Chiu YH1,2Williams PL2,3Gillman MW4,5Gaskins AJ1,6Mínguez-Alarcón L7Souter I8Toth TL8Ford JB7Hauser R2,7,8Chavarro JE1,2,6EARTH Study Team.

Hum Reprod. 2015 Jun;30(6):1342-51. doi: 10.1093/humrep/dev064. Epub 2015 Mar 30. Fruit and vegetable intake and their pesticide residues in relation to semen quality among men from a fertility clinic.

Chiu YH1Afeiche MC2Gaskins AJ3Williams PL4Petrozza JC5Tanrikut C6Hauser R7Chavarro JE8.

CNN Exclusive: “The more opioids doctors prescribe, the more money they make”

Story by Aaron KesslerElizabeth Cohen and Katherine Grise. Updated 8:45 AM ET, Mon March 12, 2018: https://www.cnn.com/2018/03/11/health/prescription-opioid-payments-eprise/index.html.

Jonathan C Hill, David GT Whitehurst, Martyn Lewis, Stirling Bryan, Kate M Dunn, Nadine E Foster, Kika Konstantinou, Chris J Main, Elizabeth Mason, Simon Somerville, Gail Sowden, Kanchan Vohora, Elaine M Hay. Comparison of stratified primary care management for low back pain with current best practice (STarT Back): a randomised controlled trial. The Lancet, 2011; 378 (9802): 1560 DOI: 10.1016/S0140-6736(11)60937-9

What low back pain is and why we need to pay attention. Jan Hartvigsen, Mark J Hancock, Alice Kongsted, Quinette Louw, Manuela L Ferreira, Stéphane Genevay, Damian Hoy, Jaro Karppinen, Glenn Pransky, Joachim Sieper, Rob J Smeets, Martin Underwood on behalf of the Lancet Low Back Pain Series Working Group

The Lancet, March 21, 2018. http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30480-X/fulltext.

Eva Benito, Cemil Kerimoglu, Binu Ramachandran, Tonatiuh Pena-Centeno, Gaurav Jain, Roman Manuel Stilling, Md Rezaul Islam, Vincenzo Capece, Qihui Zhou, Dieter Edbauer, Camin Dean, André Fischer. RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental EnrichmentCell Reports, 2018; 23 (2): 546 DOI: 10.1016/j.celrep.2018.03.059.

NEWS – CALORIE RESTRICTION

  1. Redman, L.M., et al., Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging. Cell Metab, 2018. http://www.cell.com/cell-metabolism/pdf/S1550-4131(18)30130-X.pdf.
  2. Williams, D.S., et al., Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Aging Cell, 2009. 8(6): p. 765-8.
  3. Edwards, C.B., et al., Malate and Fumarate Extend Lifespan in Caenorhabditis elegans. PLoS One, 2013. 8(3): p. e58345.
  4. Nogueira, L., Acute Oxaloacetate Exposure Enhances Resistance to Fatigue in in vitro Mouse Soleus Muscle. FASEB Journal, 2011. 25(1104.5).

Christopher R. Martens, Blair A. Denman, Melissa R. Mazzo, Michael L. Armstrong,

Nichole Reisdorph, Matthew B. Mcqueen, Michel Chonchol, Douglas R. Seals. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD in healthy middle-aged and older adultsNature Communications, 2018; DOI: 10.1038/s41467-018-03421-7.

Hypertension – BEN BROWN

  1. Appel LJ, Brands MW, Daniels SR, Karanja N, Elmer PJ, Sacks FM; American Heart Association. Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association. Hypertension. 2006 Feb;47(2):296-308.
  2. Schwingshackl L, Schwedhelm C, Hoffmann G, Knüppel S, Iqbal K, Andriolo V, Bechthold A, Schlesinger S, Boeing H. Food Groups and Risk of Hypertension: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies. Adv Nutr. 2017 Nov 15;8(6):793-803.
  3. Lennon SL, DellaValle DM, Rodder SG, Prest M, Sinley RC, Hoy MK, Papoutsakis C. 2015 Evidence Analysis Library Evidence-Based Nutrition Practice Guideline for the Management of Hypertension in Adults. J Acad Nutr Diet. 2017 Sep;117(9):1445-1458.e17.
  4. Ndanuko RN, Tapsell LC, Charlton KE, Neale EP, Batterham MJ. Dietary Patterns  and Blood Pressure in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Adv Nutr. 2016 Jan 15;7(1):76-89.
  5. Champagne CM. Dietary interventions on blood pressure: the Dietary Approaches  to Stop Hypertension (DASH) trials. Nutr Rev. 2006 Feb;64(2 Pt 2):S53-6.
  6. Appel LJ, Moore TJ, Obarzanek E, et al. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med. 1997 Apr 17;336(16):1117-24.
  7. Saneei P, Salehi-Abargouei A, Esmaillzadeh A, Azadbakht L. Influence of Dietary Approaches to Stop Hypertension (DASH) diet on blood pressure: a systematic review and meta-analysis on randomized controlled trials. Nutr Metab Cardiovasc Dis. 2014 Dec;24(12):1253-61.
  8. Gay HC, Rao SG, Vaccarino V, Ali MK. Effects of Different Dietary Interventions on Blood Pressure: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Hypertension. 2016 Apr;67(4):733-9.
  9. Siervo M, Lara J, Chowdhury S, Ashor A, Oggioni C, Mathers JC. Effects of the  Dietary Approach to Stop Hypertension (DASH) diet on cardiovascular risk factors: a systematic review and meta-analysis. Br J Nutr. 2015 Jan 14;113(1):1-15.
  10. Salehi-Abargouei A, Maghsoudi Z, Shirani F, Azadbakht L. Effects of Dietary Approaches to Stop Hypertension (DASH)-style diet on fatal or nonfatal cardiovascular diseases–incidence: a systematic review and meta-analysis on observational prospective studies. Nutrition. 2013 Apr;29(4):611-8.
  11. Tuso P, Stoll SR, Li WW. A plant-based diet, atherogenesis, and coronary artery disease prevention. Perm J. 2015 Winter;19(1):62-7.
  12. Yokoyama Y, Nishimura K, Barnard ND, Takegami M, Watanabe M, Sekikawa A, Okamura T, Miyamoto Y. Vegetarian diets and blood pressure: a meta-analysis. JAMA Intern Med. 2014 Apr;174(4):577-87.
  13. Mozaffarian D, Fahimi S, Singh GM, et al. Global sodium consumption and death from cardiovascular causes. N Engl J Med 2014;371(7):624–34.
  14. Anderson CA, Johnson RK, Kris-Etherton PM, Miller EA. Commentary on Making Sense of the Science of Sodium. Nutr Today. 2015 Mar;50(2):66-71.
  15. Heaney RP. Making Sense of the Science of Sodium. Nutr Today. 2015 Mar;50(2):63-66.
  16. Rexhaj E, Messerli FH, Cerny D, Bohlender J. Salt and Blood Pressure: Cutting Through the Scientific Fog. Curr Hypertens Rep. 2017 Jun;19(6):47.
  17. DiNicolantonio JJ, Mehta V, O’Keefe JH. Is Salt a Culprit or an Innocent Bystander in Hypertension? A Hypothesis Challenging the Ancient Paradigm. Am J Med. 2017 Aug;130(8):893-899.
  18. DiNicolantonio JJ, O’Keefe JH. Hypertension Due to Toxic White Crystals in the Diet: Should We Blame Salt or Sugar? Prog Cardiovasc Dis. 2016 Nov-Dec;59(3):219-225.
  19. Jenkins DJ, Kendall CW, Faulkner DA, Kemp T, Marchie A, Nguyen TH, Wong JM, de Souza R, Emam A, Vidgen E, Trautwein EA, Lapsley KG, Josse RG, Leiter LA, Singer  W. Long-term effects of a plant-based dietary portfolio of cholesterol-lowering foods on blood pressure. Eur J Clin Nutr. 2008 Jun;62(6):781-8.
  20. Sauder KA, McCrea CE, Ulbrecht JS, Kris-Etherton PM, West SG. Pistachio nut consumption modifies systemic hemodynamics, increases heart rate variability, and reduces ambulatory blood pressure in well-controlled type 2 diabetes: a randomized trial. J Am Heart Assoc. 2014 Jun 30;3(4).
  21. Bays H, Weiter K, Anderson J. A randomized study of raisins versus alternative snacks on glycemic control and other cardiovascular risk factors in patients with type 2 diabetes mellitus. Phys Sportsmed. 2015 Feb;43(1):37-43.
  22. Barona J, Aristizabal JC, Blesso CN, Volek JS, Fernandez ML. Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome. J Nutr. 2012 Sep;142(9):1626-32.
  23. Johnson SA, Figueroa A, Navaei N, Wong A, Kalfon R, Ormsbee LT, Feresin RG, Elam ML, Hooshmand S, Payton ME, Arjmandi BH. Daily blueberry consumption improves blood pressure and arterial stiffness in postmenopausal women with pre-  and stage 1-hypertension: a randomized, double-blind, placebo-controlled clinical trial. J Acad Nutr Diet. 2015 Mar;115(3):369-77.
  24. Toscano LT, da Silva CS, Toscano LT, de Almeida AE, Santos Ada C, Silva AS. Chia flour supplementation reduces blood pressure in hypertensive subjects. Plant Foods Hum Nutr. 2014 Dec;69(4):392-8.
  25. Rodriguez-Leyva D, Weighell W, Edel AL, LaVallee R, Dibrov E, Pinneker R, Maddaford TG, Ramjiawan B, Aliani M, Guzman R, Pierce GN. Potent antihypertensive action of dietary flaxseed in hypertensive patients. Hypertension. 2013 Dec;62(6):1081-9.
  26. Moreno-Luna R, Muñoz-Hernandez R, Miranda ML, Costa AF, Jimenez-Jimenez L, Vallejo-Vaz AJ, Muriana FJ, Villar J, Stiefel P. Olive oil polyphenols decrease blood pressure and improve endothelial function in young women with mild hypertension. Am J Hypertens. 2012 Dec;25(12):1299-304.
  27. Serban C, et al. Effect of sour tea (Hibiscus sabdariffa L.) on arterial hypertension: a systematic review and meta-analysis of randomized controlled trials. J Hypertens. 2015 Jun;33(6):1119-27
  28. Sahebkar A, Ferri C, Giorgini P, Bo S, Nachtigal P, Grassi D. Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2017 Jan;115:149-161.
  29. Moran JP, Cohen L, Greene JM, Xu G, Feldman EB, Hames CG, Feldman DS. Plasma ascorbic acid concentrations relate inversely to blood pressure in human subjects. Am J Clin Nutr 1993;57:213–7
  30. Chen GC, Lu DB, Pang Z, Liu QF. Vitamin C intake, circulating vitamin C and risk of stroke: a meta-analysis of prospective studies. J Am Heart Assoc. 2013 Nov 27;2(6):e000329.
  31. Juraschek SP, Guallar E, Appel LJ, Miller ER 3rd. Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2012 May;95(5):1079-88.
  32. Moser MA, Chun OK. Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies. Int J Mol Sci. 2016 Aug 12;17(8).
  33. Sato K, Dohi Y, Kojima M, Miyagawa K, Takase H, Katada E, Suzuki S. Effects of ascorbic acid on ambulatory blood pressure in elderly patients with refractory hypertension. Arzneimittelforschung. 2006;56(7):535-40.
  34. McNulty H, Strain JJ, Hughes CF, Ward M. Riboflavin, MTHFR genotype and blood  pressure: A personalized approach to prevention and treatment of hypertension. Mol Aspects Med. 2017 Feb;53:2-9.
  35. Han H, Fang X, Wei X, Liu Y, Jin Z, Chen Q, Fan Z, Aaseth J, Hiyoshi A, He J,  Cao Y. Dose-response relationship between dietary magnesium intake, serum magnesium concentration and risk of hypertension: a systematic review and meta-analysis of prospective cohort studies. Nutr J. 2017 May 5;16(1):26.
  36. Kass L, Weekes J, Carpenter L. Effect of magnesium supplementation on blood pressure: a meta-analysis. Eur J Clin Nutr. 2012 Apr;66(4):411-8.
  37. Rosanoff A., Plesset M.R. Oral magnesium supplements decrease high blood pressure (SBP > 155 mm Hg) in hypertensive subjects on anti-hypertensive medications: A targeted meta-analysis. Magnes. Res. 2013;26:93–99
  38. Cunha AR, D’El-Rei J, Medeiros F, Umbelino B, Oigman W, Touyz RM, Neves MF. Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women. J Hypertens.  2017 Jan;35(1):89-97.
  39. Aburto NJ, Hanson S, Gutierrez H, Hooper L, Elliott P, Cappuccio FP. Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses. BMJ. 2013 Apr 3;346:f1378.
  40. Poorolajal J, Zeraati F, Soltanian AR, Sheikh V, Hooshmand E, Maleki A. Oral potassium supplementation for management of essential hypertension: A meta-analysis of randomized controlled trials. PLoS One. 2017 Apr 18;12(4):e0174967.
  41. Houston MC. The importance of potassium in managing hypertension. Curr Hypertens Rep. 2011 Aug;13(4):309-17.
  42. Houston MC, Harper KJ. Potassium, magnesium, and calcium: their role in both the cause and treatment of hypertension. J Clin Hypertens 2008; 10 (7 S2): 3–11
  43. Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial. Phytother Res. 2018 Feb 22. doi: 10.1002/ptr.6046. [Epub ahead of print]
  44. Rizza S, Muniyappa R, Iantorno M, Kim JA, Chen H, Pullikotil P, Senese N, Tesauro M, Lauro D, Cardillo C, Quon MJ. Citrus polyphenol hesperidin stimulates  production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. J Clin Endocrinol Metab. 2011 May;96(5):E782-92.
  45. Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Hesperidin Supplementation Alleviates Oxidative DNA Damage and Lipid Peroxidation in Type 2  Diabetes: A Randomized Double-Blind Placebo-Controlled Clinical Trial. Phytother  Res. 2017 Oct;31(10):1539-1545.

 Toxins – Dr BEN LYNCH

  1. PLoS One.2014 Sep 24;9(9):e108098. doi: 10.1371/journal.pone.0108098. eCollection 2014. Dietary sources of methylated arsenic species in urine of the United States population, NHANES 2003-2010. deCastro BR1Caldwell KL1Jones RL1Blount BC1Pan Y1Ward C1Mortensen ME1.

Evidence-Based Medicine – Dr JASON FUNG

  1. N Engl J Med.2007 Apr 12;356(15):1503-16. Epub 2007 Mar 26.

Optimal medical therapy with or without PCI for stable coronary disease.

Boden WE1O’Rourke RATeo KKHartigan PMMaron DJKostuk WJKnudtson MDada MCasperson PHarris CLChaitman BRShaw LGosselin GNawaz STitle LMGau GBlaustein ASBooth DCBates ERSpertus JABerman DSMancini GBWeintraub WSCOURAGE Trial Research Group.

  1. Lancet.2018 Jan 6;391(10115):31-40. doi: 10.1016/S0140-6736(17)32714-9. Epub 2017 Nov 2.

Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial.

Al-Lamee R1Thompson D1Dehbi HM2Sen S1Tang K3Davies J3Keeble T3Mielewczik M4Kaprielian R5Malik IS5Nijjer SS5Petraco R1Cook C1Ahmad Y1Howard J1Baker C5Sharp A6Gerber R7Talwar S8Assomull R5Mayet J1Wensel R4Collier D9Shun-Shin M1Thom SA1Davies JE10Francis DP1ORBITA investigators.

  1. Offline: What is medicine’s 5 sigma?

Richard Horton. The Lancet, 11 April 2015. DOI: https://doi.org/10.1016/S0140-6736(15)60696-1.

  1. Drug Companies & Doctors: A Story of Corruption

Marcia Angell. New York Review of Books, Jan 15, 2009.

  1. New Repub.2002 Dec 16;227(25):27-41.

America’s other drug problem: how the drug industry distorts medicine and politics. Relman AS, Angell M.

  1. Ann Intern Med.2010 Aug 3;153(3):158-66. doi: 10.7326/0003-4819-153-3-201008030-00006. Outcome reporting among drug trials registered in ClinicalTrials.gov. Bourgeois FT, Murthy S, Mandl KD.
  2. N Engl J Med.2008 Jan 17;358(3):252-60. doi: 10.1056/NEJMsa065779.

Selective publication of antidepressant trials and its influence on apparent efficacy. Turner EH, Matthews AM, Linardatos E, Tell RA, Rosenthal R.

  1. N Engl J Med.2010 May 13;362(19):1761-71. doi: 10.1056/NEJMoa1001086. Epub 2010 Mar 24. Bisphosphonates and fractures of the subtrochanteric or diaphyseal femur. Black DM, Kelly MP, Genant HKPalermo LEastell RBucci-Rechtweg CCauley JLeung PC, Boonen S, Santora A, de Papp A, Bauer DC; Fracture Intervention Trial Steering Committee; HORIZON Pivotal Fracture Trial Steering Committee.
  1. PLoS Med. 2010 Oct; 7(10): e1000355. Published online 2010 Oct 26. doi:  10.1371/journal.pmed.1000355

Editors, Publishers, Impact Factors, and Reprint Income. Harvey Marcovitch.

  1. Payments by US pharmaceutical and medical device manufacturers to US medical journal editors: retrospective observational study. BMJ2017; 359 doi: https://doi.org/10.1136/bmj.j4619(Published 26 October 2017).
  2. Eur J Neurol.2017 Aug;24(8):1071-1076. doi: 10.1111/ene.13336. Epub 2017 Jun 21. Discontinuation and non-publication of neurodegenerative disease trials: a cross-sectional analysis. Stefaniak JD1, Lam TCH2, Sim NE3, Al-Shahi Salman R4, Breen DP.
  3. N Engl J Med.2007 Apr 26;356(17):1742-50. A national survey of physician-industry relationships. Campbell EG1, Gruen RL, Mountford J, Miller LG, Cleary PD, Blumenthal D.
  4. WMJ.2010 Jun;109(3):142-8. Medical student exposure to and attitudes about pharmaceutical companies. Soyk C1Pfefferkorn BMcBride PRieselbach R.
  5. BMJ.2010 Mar 18;340:c1344. doi: 10.1136/bmj.c1344.

Association between industry affiliation and position on cardiovascular risk with rosiglitazone: cross sectional systematic review. Wang AT1McCoy CPMurad MHMontori VM.

SPORTS NUTRITION – SIMON MARTIN

  1. https://www.marksdailyapple.com/should-i-supplement-testosterone.
  2. https://www.wada-ama.org/en/what-we-do/science-medical/therapeutic-use-exemptions
  3. https://bengreenfieldfitness.com/article/brain-articles/what-is-qualia.
  4. Lactate metabolism: historical context, prior misinterpretations, and current understanding. Brian S. Ferguson, Matthew J. Rogatzki, Matthew L. Goodwin, Daniel A. Kane, Zachary Rightmire, L. Bruce Gladden. European Journal of Applied Physiology. Published online Jan 2018. https://doi.org/10.1007/s00421-017-3795-6.
  5. Exercise-Induced Inflammatory Response: To Use or Not use Anti-Inflammatory Medication. Albená Nunes-Silva. Journal of Sports Medicine & Doping Studies 2014, 4:142. doi: 10.4172/2161-0673.1000142. Experimental Gerontology, Volume 69, September 2015, Pages 159-169.
  6. Exp Gerontol.2015 Sep;69:159-69. A standardized randomized 6-month aerobic exercise-training down-regulated pro-inflammatory genes, but up-regulated anti-inflammatory, neuron survival and axon growth-related genes.

Iyalomhe O1Chen Y2Allard J3Ntekim O4Johnson S3Bond V1Goerlitz D5Li J5Obisesan TO6. https://doi.org/10.1016/j.exger.2015.05.005

  1. “Chapter 7 – Supplemental Antioxidants and Adaptation to Physical Training”,

Micah Gross and Oliver Baum in Antioxidants in Sport Nutrition, Lamprecht M, editor.

Boca Raton (FL): CRC Press/Taylor & Francis; 2015.

  1. http://www.velon.cc/en/news/2017/10/team-behind-the-team-cannondale-drapac-nigel-mitchell.
  2. Phys Sportsmed.2014 Sep;42(3):45-52. doi: 10.3810/psm.2014.09.2075.

Validation of musculoskeletal ultrasound to assess and quantify muscle glycogen content. A novel approach. Hill JC1Millán IS.

  1. J Acad Nutr Diet.2016 Mar;116(3):501-528. doi: 10.1016/j.jand.2015.12.006.

Position of the Academy of Nutrition and Dietetics, Dietitians of Canada, and the American College of Sports Medicine: Nutrition and Athletic Performance.

Thomas DT1Erdman KA2Burke LM3.

  1. Eur J Appl Physiol.2017 Feb;117(2):247-254. doi: 10.1007/s00421-016-3512-x. Epub 2016 Dec 24. Cardiovascular function during supine rest in endurance-trained males with New Zealand blackcurrant: a dose-response study.

Cook MD1Myers SD1Gault ML1Edwards VC1Willems ME2.
12. Int J Sport Nutr Exerc Metab. 2015 Aug;25(4):367-74. doi: 10.1123/ijsnem.2014-0233. Epub 2015 Mar 26. Beneficial Physiological Effects With Blackcurrant Intake in Endurance Athletes. Willems ME1Myers SDGault MLCook MD.

  1. Adv Ther.2011 Dec;28(12):1078-88. doi: 10.1007/s12325-011-0083-4. Epub 2011 Nov 24. A new ginkgo fresh plant extract increases microcirculation and radical scavenging activity in elderly patients. Suter A1Niemer WKlopp R.
  2. Relationship between Vitamin D deficiency and athletic performance: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289217.
  3. Sports Med.2007;37(4-5):412-5. Marathon training and immune function. Nieman DC1.
    16. Int J Sport Nutr Exerc Metab.2013 Apr;23(2):161-9. Epub 2012 Dec 7.

Effects of DHA-rich fish oil supplementation on lymphocyte function before and after a marathon race.

Santos VC1Levada-Pires ACAlves SRPithon-Curi TCCuri RCury-Boaventura MF.

  1. Influence of a montmorency cherry juice blend on indices of exercise-induced stress and upper respiratory tract symptoms following marathon running—a pilot investigation. Lygeri Dimitriou,Jessica A HillAhmed JehnaliJoe DunbarJames BrounerMalachy P. McHugh, and Glyn Howatson. J Int Soc Sports Nutr. 2015; 12: 22.

Published online 2015 May 11. doi:  10.1186/s12970-015-0085-8.

  1. McNaughton, L, Bentley, D and Koeppel, P, The effects of a nucleotide supplement on the immune and metabolic response to short term, high intensity exercise performance in trained male subjects. J Sports Med Phys Fitness46: 112-118, 2007.
    19. Ostojic, SM and Obrenovic, M. Sublingual nucleotides and immune response to exercise. J IntSoc Sports Nutr 9: 31, 2012.
  2. Asian Journal of Pharmaceutical Sciences. Volume 12, Issue 3, May 2017, Pages 209-215. The role of serratiopeptidase in the resolution of inflammation. Review.

ManjuTiwari

  1. J Clin Exp Dent.2015 Apr 1;7(2):e197-202. doi: 10.4317/jced.51868. eCollection 2015 Apr. Comparison of clinical efficacy of methylprednisolone and serratiopeptidase for reduction of postoperative sequelae after lower third molar surgery. Chappi D M1Suresh KV2Patil MR3Desai R4Tauro DP5Bharani K N S S6Parkar MI7Babaji HV8.
  2. J Maxillofac Oral Surg.2018 Jun;17(2):122-128. doi: 10.1007/s12663-017-0996-9. Epub 2017 Jan 18. Role of Serratiopeptidase After Surgical Removal of Impacted Molar: A Systematic Review and Meta-analysis. Sivaramakrishnan G1Sridharan K2.
  3. http://sportsscientists.com/2018/01/team-sky-marginal-games.
April 2018

NEWS
The epidemiology of multimorbidity in primary care: a retrospective cohort study. Anna Cassell, Duncan Edwards, Amelia Harshfield, Kirsty Rhodes, James Brimicombe, Rupert Payne and Simon Griffin. British Journal of General Practice 12 March 2018

BEN BROWN

[1] Cutler JA, Sorlie PD, Wolz M, Thom T, Fields LE, Roccella EJ. Trends in hypertension prevalence, awareness, treatment, and control rates in United States adults between 1988-1994 and 1999-2004. Hypertension 2008;52:818-827.

1.      Messerli FH, Williams B, Ritz E. Essential hypertension. Lancet. 2007 Aug 18;370(9587):591-603.2.      Mills KT, Bundy JD, Kelly TN, Reed JE, Kearney PM, Reynolds K, Chen J, He J. Global Disparities of Hypertension Prevalence and Control: A Systematic Analysis  of Population-Based Studies From 90 Countries. Circulation. 2016 Aug 9;134(6):441-50.3.      Hajjar I, Kotchen TA. Trends in prevalence, awareness, treatment, and control  of hypertension in the United States, 1988-2000. JAMA. 2003 Jul 9;290(2):199-206.4.      Centers for Disease Control and Prevention (CDC). Vital signs: prevalence, treatment, and control of hypertension–United States, 1999-2002 and 2005-2008. MMWR Morb Mortal Wkly Rep. 2011 Feb 4;60(4):103-8.5.      Chobanian AV, Bakris GL, Black HR, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC  7 report. JAMA. 2003 May 21;289(19):2560-72.6.      Lawes CM, Vander Hoorn S, Rodgers A; International Society of Hypertension. Global burden of blood-pressure-related disease, 2001. Lancet. 2008 May 3;371(9623):1513-8.

  1. Cutler JA, Sorlie PD, Wolz M, Thom T, Fields LE, Roccella EJ. Trends in hypertension prevalence, awareness, treatment, and control rates in United States adults between 1988-1994 and 1999-2004. Hypertension2008;52:818-827

8.      Sarafidis PA, Georgianos P, Bakris GL. Resistant hypertension—its identification and epidemiology. Nat Rev Nephrol. 2013 Jan;9(1):51-8.9.      Gurven M, Blackwell AD, Rodríguez DE, Stieglitz J, Kaplan H. Does blood pressure inevitably rise with age?: longitudinal evidence among forager-horticulturalists. Hypertension. 2012 Jul;60(1):25-33.10.  Bolívar JJ. Essential hypertension: an approach to its etiology and neurogenic pathophysiology. Int J Hypertens. 2013;2013:547809.11.  Beevers G, Lip GY, O’Brien E. ABC of hypertension: The pathophysiology of hypertension. BMJ. 2001 Apr 14;322(7291):912-6.12.  Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol. 2014 Feb 26;6(2):38-66.13.  James PA, Oparil S, Carter BL, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014 Feb  5;311(5):507-20.14.  Go AS, Bauman MA, Coleman King SM, Fonarow GC, Lawrence W, Williams KA, Sanchez E. An effective approach to high blood pressure control: a science advisory from the American Heart Association, the American College of Cardiology, and the Centers for Disease Control and Prevention. J Am Coll Cardiol. 2014 Apr 1;63(12):1230-1238.15.  Ferdinand KC, Nasser SA. Management of Essential Hypertension. Cardiol Clin. 2017 May;35(2):231-246.16.  Chobanian AV. Shattuck Lecture. The hypertension paradox–more uncontrolled disease despite improved therapy. N Engl J Med. 2009 Aug 27;361(9):878-87. 17.  Hedegaard U, Kjeldsen LJ, Pottegård A, Henriksen JE, Lambrechtsen J, Hangaard  J, Hallas J. Improving Medication Adherence in Patients with Hypertension: A Randomized Trial. Am J Med. 2015 Dec;128(12):1351-61.18.  Hajjar I, Kotchen TA. Trends in prevalence, awareness, treatment, and control of hypertension in the United States, 1988-2000. JAMA. 2003 Jul 9;290(2):199-206.19.  Savoia C, Volpe M, Grassi G, Borghi C, Agabiti Rosei E, Touyz RM. Personalized medicine-a modern approach for the diagnosis and management of hypertension. Clin Sci (Lond). 2017 Nov 6;131(22):2671-2685.20.  Aggarwal M, Aggarwal B, Rao J. Integrative Medicine for Cardiovascular Disease and Prevention. Med Clin North Am. 2017 Sep;101(5):895-923.21.  Houston M. Nutrition and nutraceutical supplements for the treatment of hypertension: part I. J Clin Hypertens (Greenwich). 2013 Oct;15(10):752-7.22.  Houston M. Nutrition and nutraceutical supplements for the treatment of hypertension: part II. J Clin Hypertens (Greenwich). 2013 Nov;15(11):845-51.23.  Houston M. Nutrition and nutraceutical supplements for the treatment of hypertension: part III. J Clin Hypertens (Greenwich). 2013 Dec;15(12):931-7.24.  Sirtori CR, Arnoldi A, Cicero AF. Nutraceuticals for blood pressure control. Ann Med. 2015;47(6):447-56.25.  Caligiuri SPB, Pierce GN. 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Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension. Clin Sci (Lond). 2008 May;114(10):625-34. 36.  Hummel SL, Seymour EM, Brook RD, Kolias TJ, Sheth SS, Rosenblum HR, Wells JM,  Weder AB. Low-sodium dietary approaches to stop hypertension diet reduces blood pressure, arterial stiffness, and oxidative stress in hypertensive heart failure  with preserved ejection fraction. Hypertension. 2012 Nov;60(5):1200-6.37.  Moreno-Luna R, Muñoz-Hernandez R, Miranda ML, Costa AF, Jimenez-Jimenez L, Vallejo-Vaz AJ, Muriana FJ, Villar J, Stiefel P. Olive oil polyphenols decrease blood pressure and improve endothelial function in young women with mild hypertension. Am J Hypertens. 2012 Dec;25(12):1299-304.38.  Vaisman N, Niv E. Daily consumption of red grape cell powder in a dietary dose improves cardiovascular parameters: a double blind, placebo-controlled, randomized study. Int J Food Sci Nutr. 2015 May;66(3):342-9.39.  Dikalov SI, Ungvari Z. Role of mitochondrial oxidative stress in hypertension. Am J Physiol Heart Circ Physiol. 2013 Nov 15;305(10):H1417-27.40.  Dikalova AE, Bikineyeva AT, Budzyn K, Nazarewicz RR, McCann L, Lewis W, Harrison DG, Dikalov SI. Therapeutic targeting of mitochondrial superoxide in hypertension. Circ Res. 2010 Jul 9;107(1):106-16.41.  O’Connor PM, Gutterman DD. Resurrecting hope for antioxidant treatment of cardiovascular disease: focus on mitochondria. Circ Res. 2010 Jul 9;107(1):9-11. 42.  Liu Y, Li Y, Zhu C, Tian L, Guan M, Chen Y. Mitochondrial biogenesis dysfunction and metabolic dysfunction from a novel mitochondrial tRNA(Met) 4467 C>A mutation in a Han Chinese family with maternally inherited hypertension. Sci  Rep. 2017 Jun 8;7(1):3034.43.  Yang Q, Kim SK, Sun F, Cui J, Larson MG, Vasan RS, Levy D, Schwartz F. Maternal influence on blood pressure suggests involvement of mitochondrial DNA in the pathogenesis of hypertension: the Framingham Heart Study. J Hypertens. 2007 Oct;25(10):2067-73.44.  Dikalov SI, Dikalova AE. Contribution of mitochondrial oxidative stress to hypertension. Curr Opin Nephrol Hypertens. 2016 Mar;25(2):73-80.45.  Langsjoen PH, Langsjoen AM. Overview of the use of CoQ10 in cardiovascular disease. Biofactors. 1999;9(2-4):273-84.46.  Singh RB, Niaz MA, Rastogi SS, Shukla PK, Thakur AS. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens. 1999 Mar;13(3):203-8.47.  Kędziora-Kornatowska K, Czuczejko J, Motyl J, Szewczyk-Golec K, Kozakiewicz M, Pawluk H, Kędziora J, Błaszczak R, Banach M, Rysz J. Effects of coenzyme Q10 supplementation on activities of selected antioxidative enzymes and lipid peroxidation in hypertensive patients treated with indapamide. A pilot study. Arch Med Sci. 2010 Aug 30;6(4):513-8.48.  Bagheri Nesami N, Mozaffari-Khosravi H, Najarzadeh A, Salehifar E. The Effect  of Coenzyme Q10 Supplementation on Pro-Inflammatory Factors and Adiponectin in Mildly Hypertensive Patients: A Randomized, Double-Blind, Placebo-Controlled Trial. Int J Vitam Nutr Res. 2015;85(3-4):156-64.

  1. Ho MJ, Bellusci A, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension. Cochrane Database Syst Rev2009; 4: CD007435.

50.  Safar ME. Arterial stiffness as a risk factor for clinical hypertension. Nat Rev Cardiol. 2018 Feb;15(2):97-105.51.  Jamwal S, Sharma S. Vascular endothelium dysfunction: a conservative target in metabolic disorders. Inflamm Res. 2018 Jan 25. doi: 10.1007/s00011-018-1129-8.52.  Castro-Ferreira R, Cardoso R, Leite-Moreira A, Mansilha A. The Role of Endothelial Dysfunction and Inflammation in Chronic Venous Disease. Ann Vasc Surg. 2018 Jan;46:380-393.53.  Bruno RM, Masi S, Taddei M, Taddei S, Virdis A. Essential Hypertension and Functional Microvascular Ageing. High Blood Press Cardiovasc Prev. 2018 Mar;25(1):35-40.54.  Macready AL, George TW, Chong MF, Alimbetov DS, Jin Y, Vidal A, Spencer JP, Kennedy OB, Tuohy KM, Minihane AM, Gordon MH, Lovegrove JA; FLAVURS Study Group.  Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease–FLAVURS: a randomized controlled trial. Am J Clin Nutr. 2014 Mar;99(3):479-89.55.  John JH, Ziebland S, Yudkin P, Roe LS, Neil HA; Oxford Fruit and Vegetable Study Group. Effects of fruit and vegetable consumption on plasma antioxidant concentrations and blood pressure: a randomised controlled trial. Lancet. 2002 Jun 8;359(9322):1969-74.56.  Varadharaj S, Kelly OJ, Khayat RN, Kumar PS, Ahmed N, Zweier JL. Role of Dietary Antioxidants in the Preservation of Vascular Function and the Modulation  of Health and Disease. Front Cardiovasc Med. 2017 Nov 1;4:64.57.  Machha A, Schechter AN. Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits. Eur J Nutr. 2011 Aug;50(5):293-303.58.  d’El-Rei J, Cunha AR, Trindade M, Neves MF. Beneficial Effects of Dietary Nitrate on Endothelial Function and Blood Pressure Levels. Int J Hypertens. 2016;2016:6791519.

  1. Boger RH. Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the “L-arginine paradox” and acts as a novel cardiovascular risk factor. J Nutr. 2004 Oct;134(10 Suppl):2842S-2847S

60.  Dong JY, Qin JQ, Zhang ZL, et al. Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials. Am Heart J. 2011;162:959–65.

 

CONSULTATION – Garner Thomson

1. Beckman HB, Frankel RM (1984) The effect of physician behavior on the collection of data. Annals of Internal Medicine 101:692-6

2. Marvel MK (1999) Soliciting the patient’s agenda: have we improved? JAMA; 281: 283–7.

 

3. Svab I (1993) The time used by the patient when he/she talks without interruptions. Aten Primaria; 11: 175–7

 

4. Little M (1995) Humane Medicine. Cambridge:Cambridge University Press

 

5. Thomson G, Khan K (2016) Magic in Practice, London:Hammersmith Health Books

 

6.Hagger, M. S., Koch, S., Chatzisarantis, N. L. D., & Orbell, S. (2017). The common sense model of self-regulation: Meta-analysis and test of a process model. Psychological Bulletin, 143(11), 1117-1154.

ALLERGY and INFLAMMATION

References

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Kohda H, Tokumoto W, Sakamoto K, Fujii M, Hirai Y, Yamasaki K, Komoda Y, Nakamura H, Ishihara S, Uchida M (1985). The biologically active constituents of Ganodermalucidum (Fr.) Karst histamine release-inhibitory triterpenes. Chemical and PharmaceuticalBulletin 33, 1367-1374.

Powell M (2006) The use of Ganodermalucidum (Reishi) in the management of histamine-mediated allergic responses Townsend Letter. TheExaminer of Alternative Medicine 274, 26-30

Takimoto H, Kato H, Kaneko M, Kumazawa Y (2008) Amelioration of skewed Th1/Th2 balance in tumor-bearing and asthma-induced mice by oral administration of Agaricusblazei extracts. Immunopharmacology and Immunotoxicology 30, 747-760

Tasaka K, Akagi M, Miyoshi K, Mio M, Makino T (1988a) Anti-allergic constituents in the culture medium of Ganodermalucidum. (I) Inhibitory effect of oleic acid on histamine release. Agents Actions 23,153-156

Tasaka K, Mio M, Izushi K, Akagi M, Makino T (1988b) Anti-allergic constituents in the culture medium of Ganodermalucidum. (II) The inhibitory effect of cyclooctasulfur on histamine release. Agents Actions 23, 157-160

Milica Vukmanovic-Stejic, Emma S. Chambers, Mayte Suárez-Fariñas, Daisy Sandhu, Judilyn Fuentes-Duculan, Neil Patel, Elaine Agius, Katie E. Lacy, Carolin T. Turner, Anis Larbi, Veronique Birault, Mahdad Noursadeghi, Neil A. Mabbott, Malcolm H.A. Rustin, James G. Krueger, Arne N. Akbar. Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase–induced inflammationJournal of Allergy and Clinical Immunology, 2017; DOI: 10.1016/j.jaci.2017.10.032

RESEARCH

Leanne M. Redman, Steven R. Smith, Jeffrey H. Burton, Corby K. Martin, Dora Il’yasova, Eric Ravussin. Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of AgingCell Metabolism, 2018; DOI: 10.1016/j.cmet.2018.02.019

  1. Parvez, R. R. Gerona, C. Proctor, M. Friesen, J. L. Ashby, J. L. Reiter, Z. Lui, P. D. Winchester. Glyphosate exposure in pregnancy and shortened gestational length: a prospective Indiana birth cohort studyEnvironmental Health, 2018; 17 (1) DOI: 10.1186/s12940-018-0367-0

Erzsebet Polyak, Julian Ostrovsky, Min Peng, Stephen D. Dingley, Mai Tsukikawa, Young Joon Kwon, Shana E. McCormack, Michael Bennett, Rui Xiao, Christoph Seiler, Zhe Zhang, Marni J. Falk. N -acetylcysteine and vitamin E rescue animal longevity and cellular oxidative stress in pre-clinical models of mitochondrial complex I disease. Molecular Genetics and Metabolism, 2018; DOI: 10.1016/j.ymgme.2018.02.013

Eneida Boteon Schmitt, Jorge Nahas-Neto, Flavia Bueloni-Dias, Priscila Ferreira Poloni, Claudio Lera Orsatti, Eliana Aguiar Petri Nahas. Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women. Maturitas, 2018; 107: 97 DOI: 10.1016/j.maturitas.2017.10.011

Smruti Pushalkar, Mautin Hundeyin, Donnele Daley, Constantinos P. Zambirinis, Emma Kurz, Ankita Mishra, Navyatha Mohan, Berk Aykut, Mykhaylo Usyk, Luisana E. Torres, Gregor Werba, Kevin Zhang, Yuqi Guo, Qianhao Li, Neha Akkad, Sarah Lall, Benjamin Wadowski, Johana Gutierrez, Juan Andres Kochen Rossi, Jeremy W. Herzog, Brian Diskin, Alejandro Torres-Hernandez, Josh Leinwand, Wei Wang, Pardeep S. Taunk, Shivraj Savadkar, Malvin Janal, Anjana Saxena, Xin Li, Deirdre Cohen, R. Balfour Sartor, Deepak Saxena, George Miller. The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune SuppressionCancer Discovery, 2018; DOI: 10.1158/2159-8290.CD-17-1134

Brandon H Hidaka, Jocelynn M Thodosoff, Elizabeth H Kerling, Holly R Hull, John Colombo, Susan E Carlson. Intrauterine DHA exposure and child body composition at 5 y: exploratory analysis of a randomized controlled trial of prenatal DHA supplementation. The American Journal of Clinical Nutrition, 2018; 107 (1): 35 DOI: 10.1093/ajcn/nqx007

Current Opinion in Food Science, Volume 20, April 2018, Pages 19-23. CYP7A1-rs3808607: a single nucleotide polymorphism associated with cholesterol response to functional foods YongboShe12Dylan SMacKay23James DHouse2Peter JHJones. https://doi.org/10.1016/j.cofs.2018.02.013

COMMENT by Dr Eve Pearce:

Abdullah, M. M., Cyr, A., Lépine, M.-C., Eck, P. K., Couture, P., Lamarche, B., & Jones, P. J. (2016). Common Variants in Cholesterol Synthesis– and Transport–Related Genes Associate with Circulating Cholesterol Responses to Intakes of Conventional Dairy Products in Healthy Individuals. The Journal of Nutrition, 146(5), 1008–1016. http://doi.org/10.3945/jn.115.222208

De Castro-Orós, I., Pampín, S., Cofán, M., Mozas, P., Pintó, X., Salas-Salvadó, J., … Pocoví, M. (2011). Promoter variant −204A > C of the cholesterol 7α-hydroxylase gene: Association with response to plant sterols in humans and increased transcriptional activity in transfected HepG2 cells. Clinical Nutrition, 30(2), 239–246. http://doi.org/10.1016/j.clnu.2010.07.020

Jenkins, D. J. A., Kendall, C. W. C., Faulkner, D., Vidgen, E., Trautwein, E. A., Parker, T. L., … Connelly, P. W. (2002). A dietary portfolio approach to cholesterol reduction: combined effects of plant sterols, vegetable proteins, and viscous fibers in hypercholesterolemia. Metabolism: Clinical and Experimental, 51(12), 1596–604. http://doi.org/10.1053/meta.2002.35578

Juzyszyn, Z., Kurzawski, M., Lener, A., Modrzejewski, A., Pawlik, A., & Droździk, M. (2008). Cholesterol 7α-Hydrolase ( CYP7A1 ) c.−278A>C Promoter Polymorphism in Gallstone Disease Patients. Genetic Testing, 12(1), 97–100. http://doi.org/10.1089/gte.2007.0067

MacKay, D. S., Eck, P. K., Gebauer, S. K., Baer, D. J., & Jones, P. J. (2015). CYP7A1-rs3808607 and APOE isoform associate with LDL cholesterol lowering after plant sterol consumption in a randomized clinical trial. The American Journal of Clinical Nutrition, 102(4), 951–957. http://doi.org/10.3945/ajcn.115.109231

Rideout, T. C., Harding, S. V, & Mackay, D. S. (2012). Metabolic and genetic factors modulating subject specific LDL-C responses to plant sterol therapy. Canadian Journal of Physiology and Pharmacology, 90(5), 509–14. http://doi.org/10.1139/y2012-060

Russell, D. W. (2003). The enzymes, regulation, and genetics of bile acid synthesis. Annual Review of Biochemistry, 72(1), 137–74. http://doi.org/10.1146/annurev.biochem.72.121801.161712

She, Y., MacKay, D. S., House, J. D., & Jones, P. J. (2018). CYP7A1-rs3808607: a single nucleotide polymorphism associated with cholesterol response to functional foods. Current Opinion in Food Science, 20, 19–23. http://doi.org/10.1016/j.cofs.2018.02.013

 

 

 

March 2018

IHCAN March references

NEWS

Fiolet Thibault, Srour Bernard, Sellem Laury, Kesse-Guyot Emmanuelle, Allès Benjamin, Méjean Caroline et al. Consumption of ultra-processed foods and cancer risk: results from NutriNet-Santé prospective cohort. BMJ 2018; 360 :k322.

Yumi Hurst, Haruhisa Fukuda. Effects of changes in eating speed on obesity in patients with diabetes: a secondary analysis of longitudinal health check-up data. BMJ Open, 2018; 8 (1): e019589 DOI: 10.1136/bmjopen-2017-019589.

Christopher D. Gardner, John F. Trepanowski, Liana C. Del Gobbo, Michelle E. Hauser, Joseph Rigdon, John P. A. Ioannidis, Manisha Desai, Abby C. King. Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical TrialJAMA, 2018; 319 (7): 667-679 DOI: 10.1001/jama.2018.0245.

Adelaida Esteban-Fernández, Irene Zorraquín-Peña, Maria D. Ferrer, Alex Mira, Begoña Bartolomé, Dolores González de Llano, M. Victoria Moreno-Arribas. Inhibition of Oral Pathogens Adhesion to Human Gingival Fibroblasts by Wine Polyphenols Alone and in Combination with an Oral ProbioticJournal of Agricultural and Food Chemistry, 2018; DOI: 10.1021/acs.jafc.7b05466

BEN BROWN PSYCHOBIOTICS

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6.      Sarkar A, Lehto SM, Harty S, Dinan TG, Cryan JF, Burnet PW. Psychobiotics and  the Manipulation of Bacteria-Gut-Brain Signals. Trends Neurosci. 2016 Nov;39(11):763-781.7.      Shanks N, Greek R, Greek J. Are animal models predictive for humans? Philos Ethics Humanit Med. 2009 Jan 15;4:2. doi: 10.1186/1747-5341-4-2.8.      Tillisch K, Labus J, Kilpatrick L, Jiang Z, Stains J, Ebrat B, Guyonnet D, Legrain-Raspaud S, Trotin B, Naliboff B, Mayer EA. Consumption of fermented milk  product with probiotic modulates brain activity. Gastroenterology. 2013 Jun;144(7):1394-401, 1401.e1-4.9.      Romijn AR, Rucklidge JJ. Systematic review of evidence to support the theory of psychobiotics. Nutr Rev. 2015 Oct;73(10):675-93.

  1. Rucklidge J, Kaplan B. Can Probiotics be Used for the Treatment of Mental Health Problems? Mad in America. September 15, 2015.
  2. Ng QX, Peters C, Ho CYX, Lim DY, Yeo WS. A meta-analysis of the use of probiotics to alleviate depressive symptoms. J Affect Disord. 2018 Mar 1;228:13-19. doi: 10.1016/j.jad.2017.11.063.

12.  Kelly JR, Allen AP, Temko A, Hutch W, Kennedy PJ, Farid N, Murphy E, Boylan G, Bienenstock J, Cryan JF, Clarke G, Dinan TG. Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects. Brain Behav Immun. 2017 Mar;61:50-59.13.  Akkasheh G, Kashani-Poor Z, Tajabadi-Ebrahimi M, Jafari P, Akbari H, Taghizadeh M, Memarzadeh MR, Asemi Z, Esmaillzadeh A. Clinical and metabolic response to probiotic administration in patients with major depressive disorder:  A randomized, double-blind, placebo-controlled trial. Nutrition. 2016 Mar;32(3):315-20.

  1. Jacka FN, et al. A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial). BMC Medicine 2017 15:23. Published: 30 January 2017

15.  Sarris J, O’Neil A, Coulson CE, Schweitzer I, Berk M. Lifestyle medicine for depression. BMC Psychiatry. 2014 Apr 10;14:107. LYME LONG-TERM

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MUSHROOM NUTRITION1             American Chemical Society (2000, May 12). New Evidence Found Linking Herpes and Alzheimer’s. Science Daily. Retrieved July 26, 2013, from http:// www.sciencedaily.com/releases/2000/05/000512083302.htm.2             University of Manchester (2008, December 7). Cold Sore Virus Linked To Alzheimer’s Disease: New Treatment, Or Even Vaccine Possible. Science- Daily. Retrieved July 26, 2013, from http://www.sciencedaily.com /releas- es/2008/12/081207134109.htm3             MA Wozniak, AP Mee and RF Itzhaki. Herpes simplex virus type I DNA is located within Alzheimer’s disease amyloid plaques. The Journal of Pathology, Volume 217, Issue 1 , Pages131 – 138 2009 DOI: 10.1002/path.24494             Carter CJ. Alzheimer´s disease plaques and tangles:cemeteries of phyrrhic victory of the immune defence network against herpes simplex infection at the expense of complement and inflammation-mediated neuronal destruction.Neurochem Int. 2011 Feb 58(3):301-20 doi 10 1016/j.neuint 2010.12.20.003Epub 2010 Dec 15.5             Wozniak MA, Frost AL, Preston CM, Itzhaki RF.  Antivirals reduce the forma- tion of key Alzheimer´s disease molecules in cell cultures acutely infected with herpes simplex virus type 1. PLoS One. 2011:6(10) e25152 doi 10 1371/ journal. pone.0025152. EPUB 2011 Oct 7.6             Pandley JP. Immunoglobulin GM genese as functional risk and protective fac- tors for the development of Alzheimer´s disease. J. Alzheimers Dis 2009;17(4) 753-6 doi 10.3222/JAD-2009-1094.7             Wozniak MA, Itzhaki RF. Intravenous immounoglobulin reduces amyloid and abnormal tau formation caused by herpes simplex virus type 1. J Neuroimmunol 2013 Apr 15:257 (1-2):7-12 doi 10. 1016/ jnmeuroim 2013.01.005 Epub 2013Feb 4.8             Medeiros R, Kitazawa M, Passos GF, Baglietto-Vargas D, Cheng D, Cribbs  OH, LaFerla FM. Aspirin-triggered  lipoxin  A4  stimulates  alternative  activation of microglia and reduces Alzheimer disease-like pathology in mice. Am J Pathol. 2013 May, 182(5);1740-9 ..9             Jean A. Monro, Chronic Fatigue Immune Dysfunction Syndrome. J Integrative Medicine 2004; 8:101-10810           Jean A. Monro. Treatment of Cancer with Mushroom Products. Arch Env Health 2003;58:533-537.11           Silva Couto J, Pereira da Silva D. Evaluation of the Efficacy of Coriolus versicolor Supplementation in HPV Lesions (LSIL) . Poster presented at the 20th European Congress of Obstetrics and Gynecology, Lisbon, Portugal March4-8th, 2008.12           Cornelius C. , Cavallaro M., Cambria M.T., Toscano M.A., Calabrese V. Com- parative Enzyme Analysis of Polyporus umbellatus, Agaricus blazei, Pleurotus osteratus and Hericium erinaceus . Clinical Journal of Mycology 2009 Vol II Page 4 to 7.13           Kulmann I, Minihane Am, Huebbe P, Nebel A , Rimbach G. Apolipoprotien  E genotype and hepatitis c, HIV and herpes simplex diseae risk: a literature review. Lipids Health Dis. 2010 Jan 28.9.8 doi 10.1186/1476-511-9.614           Miklossy J. Emerging roles of pathogens in Alzheimer disease. Expert Rev Mol Med. 2011 Sept 20; 13 e 30 doi 10 1017/S14623994 1 1002006.  Also relevant:
Calabrese, V. Fernandes, T. Excerpt from Clinical Journal of Mycology Vol IV, Pages 10-12, Nov 2013, Aneid Press.
Trovato A, et al. Redox modulation of cellular stress response and lipoxin A4 expression by Coriolus versicolor in rat brain: Relevance to Alzheimer’s disease pathogenesis. Neurotoxicology (2015):  http://dx.doi.org/10.1016/ j.neuro.2015.09.012.

Trovato et al. Redox modulation of cellular stress response and lipoxin A4 expression byHericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis. Immunity & Ageing (2016) 13:23.  DOI 10.1186/s12979-016-0078-8. Coriolus versicolor biomass increases dendritic arborization of newly-generated neurons in mouse hippocampal dentate gyrus. Elisabete Ferreiro, Inês Pita, Nuno R. Ferreira , Carlos A Fontes-Ribeiro , Frederico C. Pereira , A. Cristina Rego. Abstract  presented February 5, 2018, at the 48th Annual Meeting of the Portuguese Society of Pharmacology, at the University of Lisbon.

RESEARCH
Attia Anwar, Provvidenza Maria Abruzzo, Sabah Pasha, Kashif Rajpoot, Alessandra Bolotta, Alessandro Ghezzo, Marina Marini, Annio Posar, Paola Visconti, Paul J. Thornalley, Naila Rabbani. Advanced glycation endproducts, dityrosine and arginine transporter dysfunction in autism – a source of biomarkers for clinical diagnosisMolecular Autism, 2018; 9 (1) DOI: 10.1186/s13229-017-0183-3.

 

Kathleen F. Holton, Peter K. Ndege, Daniel J. Clauw. Dietary correlates of chronic widespread pain in meru, KenyaNutrition, 2018; DOI: 10.1016/j.nut.2018.01.016.

Adil Mardinoglu, Hao Wu, Elias Bjornson, Cheng Zhang, Antti Hakkarainen, Sari M. Räsänen, Sunjae Lee, Rosellina M. Mancina, Mattias Bergentall, Kirsi H. Pietiläinen, Sanni Söderlund, Niina Matikainen, Marcus Ståhlman, Per-Olof Bergh, Martin Adiels, Brian D. Piening, Marit Granér, Nina Lundbom, Kevin J. Williams, Stefano Romeo, Jens Nielsen, Michael Snyder, Mathias Uhlén, Göran Bergström, Rosie Perkins, Hanns-Ulrich Marschall, Fredrik Bäckhed, Marja-Riitta Taskinen, Jan Borén. An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans. Cell Metabolism, 2018; DOI: 10.1016/j.cmet.2018.01.005.

Nicola McCleary, Bright I. Nwaru, Ulugbek B. Nurmatov, Hilary Critchley, Aziz Sheikh. Endogenous and exogenous sex steroid hormones in asthma and allergy in females: A systematic review and meta-analysisJournal of Allergy and Clinical Immunology, 2018; DOI: 10.1016/j.jaci.2017.11.034

 

MAGNESIUM – Mike Ash

  1. Thomas D. The mineral depletion of foods available to us as a nation (1940-2002) –a review of the 6th Edition of McCance and Widdowson. Nutr Health. 2007;19(1-2):21-55. 
    2. Loladze I. Hidden shift of the ionome of plants exposed to elevated CO₂ depletes minerals at the base of human nutrition. Elife. 2014 May 7.
  2. DiNicolantonio JJ, O’Keefe JH, Wilson W. Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis. Open Heart 2018;5:e000668. doi: 10.1136/openhrt-2017-000668.

 

 

 

 

 

February 2018

NEWS
Woodcock B A, Ridding L, Freeman S N, Pereira M G, Sleep D, Redhead J, et al. (2018) Neonicotinoid residues in UK honey despite European Union moratorium. DOI: 10.1371/journal.pone.0189681 (open access)

Katarina Ondrusova, Mohammad Fatehi, Amy Barr, Zofia Czarnecka, Wentong Long, Kunimasa Suzuki, Scott Campbell, Koenraad Philippaert, Matthew Hubert, Edward Tredget, Peter Kwan, Nicolas Touret, Martin Wabitsch, Kevin Y. Lee, Peter E. Light. Subcutaneous white adipocytes express a light sensitive signaling pathway mediated via a melanopsin/TRPC channel axisScientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-16689-4

Anas Raed, Jigar Bhagatwala, Haidong Zhu, Norman K. Pollock, Samip J. Parikh, Ying Huang, Robyn Havens, Ishita Kotak, De-Huang Guo, Yanbin Dong. Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial. PLOS ONE, 2017; 12 (12): e0188424 DOI: 10.1371/journal.pone.0188424

NEWS EXTRA

Infectious virus in exhaled breath of symptomatic seasonal influenza cases from a college community. PNAS 2018 ; published ahead of print January 18, 2018, doi:10.1073/pnas.1716561115. 

Enhanced aerobic exercise performance in women by a combination of three mineral Chelates plus two conditionally essential nutrients

Robert A. DiSilvestro et al. Journal of the International Society of Sports Nutrition 201714:42. https://doi.org/10.1186/s12970-017-0199-2

BEN BROWN

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9.      Dmitrašinović G, Pešić V, Stanić D, Plećaš-Solarović B, Dajak M, Ignjatović S. ACTH, Cortisol and IL-6 Levels in Athletes following Magnesium Supplementation. J Med Biochem. 2016 Nov 2;35(4):375-384.

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11.  Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012 Dec;17(12):1161-9.

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18.  de Oliveira IJ, de Souza VV, Motta V, Da-Silva SL. Effects of Oral Vitamin C Supplementation on Anxiety in Students: A Double-Blind, Randomized, Placebo-Controlled Trial. Pak J Biol Sci. 2015 Jan;18(1):11-8.

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21.  Amr M, El-Mogy A, Shams T, Vieira K, Lakhan SE. Efficacy of vitamin C as an adjunct to fluoxetine therapy in pediatric major depressive disorder: a randomized, double-blind, placebo-controlled pilot study. Nutr J. 2013 Mar 9;12:31.

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30.  Crawford MA, Bazinet RP, Sinclair AJ. Fat intake and CNS functioning: ageing and disease. Ann Nutr Metab. 2009;55(1-3):202-28.31.  Grosso G, Pajak A, Marventano S, Castellano S, Galvano F, Bucolo C, Drago F, Caraci F. Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials. PLoS One. 2014 May 7;9(5):e96905.32.  Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Glaser R. Omega- supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial. Brain Behav Immun. 2011 Nov;25(8):1725-34.33.  Liu JJ, Galfalvy HC, Cooper TB, Oquendo MA, Grunebaum MF, Mann JJ, Sublette ME. Omega-3 polyunsaturated fatty acid (PUFA) status in major depressive disorder with comorbid anxiety disorders. J Clin Psychiatry. 2013 Jul;74(7):732-8.34.  Mocking RJ, Ruhé HG, Assies J, Lok A, Koeter MW, Visser I, Bockting CL, Schene AH. Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression. Psychoneuroendocrinology. 2013 Sep;38(9):1607-17.35.  Mocking RJ, Verburg HF, Westerink AM, Assies J, Vaz FM, Koeter MW, Ruhé HG, Schene AH. Fatty acid metabolism and its longitudinal relationship with the hypothalamic-pituitary-adrenal axis in major depression: Associations with prospective antidepressant response. Psychoneuroendocrinology. 2015 Sep;59:1-13. 36.  Delarue J, Matzinger O, Binnert C, Schneiter P, Chioléro R, Tappy L. Fish oil  prevents the adrenal activation elicited by mental stress in healthy men. Diabetes Metab. 2003 Jun;29(3):289-95. 37.  Jazayeri S, Keshavarz SA, Tehrani-Doost M, Djalali M, Hosseini M, Amini H, Chamari M, Djazayery A. Effects of eicosapentaenoic acid and fluoxetine on plasma cortisol, serum interleukin-1beta and interleukin-6 concentrations in patients with major depressive disorder. Psychiatry Res. 2010 Jun 30;178(1):112-5.38.  Barbadoro P, Annino I, Ponzio E, Romanelli RM, D’Errico MM, Prospero E, Minelli A. Fish oil supplementation reduces cortisol basal levels and perceived stress: a randomized, placebo-controlled trial in abstinent alcoholics. Mol Nutr  Food Res. 2013 Jun;57(6):1110-4.39.  von Schacky C. Omega-3 index and cardiovascular health. Nutrients. 2014 Feb 21;6(2):799-814. 40.  Harris WS, Pottala JV, Lacey SM, et al. Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study. Atherosclerosis. 2012 Dec;225(2):425-31.41.  Flock MR, Skulas-Ray AC, Harris WS, et al. Determinants of erythrocyte omega-3 fatty acid content in response to fish oil supplementation: a dose-response randomized controlled trial. J Am Heart Assoc. 2013 Nov 19;2(6):e000513.

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43.  Pottala JV, Yaffe K, Robinson JG, et al. Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study. Neurology. 2014 Feb 4;82(5):435-42.44.  Pottala JV, Talley JA, Churchill SW, et al. Red blood cell fatty acids are associated with depression in a case-control study of  adolescents. Prostaglandins Leukot Essent Fatty Acids. 2012 Apr;86(4-5):161-5.45.  Baghai TC, Varallo-Bedarida G, Born C, et al. Major depressive disorder is associated with cardiovascular risk factors and low Omega-3 Index. J Clin Psychiatry. 2011 Sep;72(9):1242-7.46.  Johnston DT, Deuster PA, Harris WS, et al. Red blood cell omega-3 fatty acid levels and neurocognitive performance in deployed U.S. Servicemembers. Nutr Neurosci. 2013 Jan;16(1):30-8.47.  Türközü D, Şanlier N. L-theanine, unique amino acid of tea, and its metabolism, health effects, and safety. Crit Rev Food Sci Nutr. 2017 May 24;57(8):1681-1687.48.  Yoto A, Motoki M, Murao S, Yokogoshi H. Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses. J  Physiol Anthropol. 2012 Oct 29;31:28.

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58.  Shafiee M, Arekhi S, Omranzadeh A, Sahebkar A. Saffron in the treatment of depression, anxiety and other mental disorders: Current evidence and potential mechanisms of action. J Affect Disord. 2017 Nov 7;227:330-337.59.  Lopresti AL, Drummond PD. Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action. Hum Psychopharmacol. 2014 Nov;29(6):517-27.

  1. Basiri-Moghadam M, et al. Comparison of the Anxiolytic Effects of Saffron (Crocus sativus. L) and Diazepam Before Herniorrhaphy Surgery: A Double Blind Randomized Clinical Trial. Zahedan J Res Med Sci. 2016 March; 18(3):e6248.

61.  Kell G, Rao A, Beccaria G, Clayton P, Inarejos-García AM, Prodanov M. affron(®) a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial. Complement Ther Med. 2017 Aug;33:58-64.62.  Mazidi M, Shemshian M, Mousavi SH, Norouzy A, Kermani T, Moghiman T, Sadeghi A, Mokhber N, Ghayour-Mobarhan M, Ferns GA. A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression. J Complement Integr Med. 2016 Jun 1;13(2):195-9.63.  Ghajar A, Neishabouri SM, Velayati N, et al. Crocus sativus L. versus Citalopram in the Treatment of Major Depressive Disorder with Anxious Distress: A Double-Blind, Controlled Clinical Trial. Pharmacopsychiatry. 2017 Jul;50(4):152-160.64.  Hooshmandi Z, Rohani AH, Eidi A, Fatahi Z, Golmanesh L, Sahraei H. Reduction of metabolic and behavioral signs of acute stress in male Wistar rats by saffron  water extract and its constituent safranal. Pharm Biol. 2011 Sep;49(9):947-54.65.  Fukui H, Toyoshima K, Komaki R. Psychological and neuroendocrinological effects of odor of saffron (Crocus sativus). Phytomedicine. 2011 Jun 15;18(8-9):726-30.66.  Shakeri A, Sahebkar A, Javadi B. Melissa officinalis L. – A review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol. 2016 Jul 21;188:204-28.67.  Kennedy DO, Scholey AB, Tildesley NT, Perry EK, Wesnes KA. Modulation of mood  and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav. 2002 Jul;72(4):953-64.68.  Kennedy DO, Little W, Scholey AB. Attenuation of laboratory-induced stress in  humans after acute administration of Melissa officinalis (Lemon Balm). Psychosom  Med. 2004 Jul-Aug;66(4):607-13.69.  Kennedy DO, Wake G, Savelev S, et al.  Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacology. 2003 Oct;28(10):1871-81.70.  Cases J, Ibarra A, Feuillère N, Roller M, Sukkar SG. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Med J Nutrition Metab. 2011 Dec;4(3):211-218.71.  Akbarzadeh M, Dehghani M, Moshfeghy Z, Emamghoreishi M, Tavakoli P, Zare N. Effect of Melissa officinalis Capsule on the Intensity of Premenstrual Syndrome Symptoms in High School Girl Students. Nurs Midwifery Stud. 2015 Jun;4(2):e27001.72.  Ibarra A, Feuillere N, Roller M, Lesburgere E, Beracochea D. Effects of chronic administration of Melissa officinalis L. extract on anxiety-like reactivity and on circadian and exploratory activities in mice. Phytomedicine. 2010 May;17(6):397-403.73.  Pratte MA, Nanavati KB, Young V, Morley CP. An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). J Altern Complement Med. 2014 Dec;20(12):901-8. doi: 10.1089/acm.2014.0177.74.  Choudhary D, Bhattacharyya S, Joshi K. Body Weight Management in Adults Under  Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial. J Evid Based Complementary Altern Med. 2017 Jan;22(1):96-106.

  1. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012 Jul;34(3):255-62.
  2. Auddy B, et al. A Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled Study. Journal of the American Nutraceutical Association. 2008;11(1):50-56.

77.  Amsterdam JD, Panossian AG. Rhodiola rosea L. as a putative botanical antidepressant. Phytomedicine. 2016 Jun 15;23(7):770-83.

  1. Darbinyan, A. Kteyan, A. Panossian, E. Gabrielian, G. Wikman, H. Wagner. 2000. Rhodiola rosea in stress induced fatigue — A double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. PhytomedicineVolume 7, Issue 5, October 2000, Pages 365–371.
  2. A. Spasov, G.K. Wikman, V.B. Mandrikov, I.A. Mironova, V.V. Neumoin. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. Volume 7, Issue 2, April 2000, Pages 85–89.
  3. Panossian A, Wikman G, Sarris J. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine. 2010;17(7):481-493.
  4. Kasper S, Dienel A. Multicenter, open-label, exploratory clinical trial with Rhodiola rosea extract in patients suffering from burnout symptoms.Neuropsychiatr Dis Treat. 2017 Mar 22;13:889-898.
  5. Lekomtseva Y, Zhukova I, Wacker A. Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial. Complement  Med Res. 2017;24(1):46-52.

83.  Olsson EM, von Schéele B, Panossian AG. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. 2009 Feb;75(2):105-12.84.  Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med. 2008 Mar;14(2):175-80.85.  Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malmström C, Panossian A. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nord J Psychiatry. 2007;61(5):343-8.

  1. Mao JJ, Xie SX, Zee J, Soeller I, Li QS, Rockwell K, Amsterdam JD. Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial. Phytomedicine. 2015 Mar 15;22(3):394-9.
  2. Amsterdam JD, Li Y, Soeller I, Rockwell K, Mao JJ, Shults J. A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. J Clin Psychopharmacol. 2009 Aug;29(4):378-82.

88.  Amsterdam JD, Shults J, Soeller I, Mao JJ, Rockwell K, Newberg AB. Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study. Altern Ther Health Med. 2012 Sep-Oct;18(5):44-9.89.  Keefe JR, Mao JJ, Soeller I, Li QS, Amsterdam JD. Short-term open-label chamomile (Matricaria chamomilla L.) therapy of moderate to severe generalized anxiety disorder. Phytomedicine. 2016 Dec 15;23(14):1699-1705.

  1. Keefe JR, Guo W, Li QS, Amsterdam JD, Mao JJ. An exploratory study of salivary cortisol changes during chamomile extract therapy of moderate to severe generalized anxiety disorder. J Psychiatr Res. 2018 Jan;96:189-195.
  1. Delarue J, Matzinger O, Binnert C, Schneiter P, Chioléro R, Tappy L. Fish oil  prevents the adrenal activation elicited by mental stress in healthy men. Diabetes Metab. 2003 Jun;29(3):289-95.

 

GUT RESEARCH

Kourosh Kalantar-Zadeh, Kyle J. Berean, Nam Ha, Adam F. Chrimes, Kai Xu, Danilla Grando, Jian Zhen Ou, Naresh Pillai, Jos L. Campbell, Robert Brkljača, Kirstin M. Taylor, Rebecca E. Burgell, Chu K. Yao, Stephanie A. Ward, Chris S. McSweeney, Jane G. Muir, Peter R. Gibson. A human pilot trial of ingestible electronic capsules capable of sensing different gases in the gutNature Electronics, 2018; 1 (1): 79 DOI: 10.1038/s41928-017-0004-x.

Paleo diet: material supplied by Umeå universitet: http://www.umu.se/english – dissertation available there.

Stephen A. Fleming, Supida Monaikul, Alexander J. Patsavas, Rosaline V. Waworuntu, Brian M. Berg, Ryan N. Dilger. Dietary polydextrose and galactooligosaccharide increase exploratory behavior, improve recognition memory, and alter neurochemistry in the young pigNutritional Neuroscience, 2017; 1 DOI: 10.1080/1028415X.2017.1415280.

Giuseppe Faraco, David Brea, Lidia Garcia-Bonilla, Gang Wang, Gianfranco Racchumi, Haejoo Chang, Izaskun Buendia, Monica M. Santisteban, Steven G. Segarra, Kenzo Koizumi, Yukio Sugiyama, Michelle Murphy, Henning Voss, Joseph Anrather, Costantino Iadecola. Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 responseNature Neuroscience, 2018; DOI: 10.1038/s41593-017-0059-z

Salt stats: https://www.gov.uk/government/news/new-phe-data-on-salt-consumption-levels.

Irina Leonardi et al. CX3CR1 mononuclear phagocytes control immunity to intestinal fungiScience, 2018 DOI: 10.1126/science.aao1503.

Sébastien Lucas, Yasunori Omata, Jörg Hofmann, Martin Böttcher, Aida Iljazovic, Kerstin Sarter, Olivia Albrecht, Oscar Schulz, Brenda Krishnacoumar, Gerhard Krönke, Martin Herrmann, Dimitrios Mougiakakos, Till Strowig, Georg Schett, Mario M. Zaiss. Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-017-02490-4

RESEARCH UPDATE

Yu-Jin Jung, Young-Tae Lee, Vu Le Ngo, Young-Hee Cho, Eun-Ju Ko, Sung-Moon Hong, Ki-Hye Kim, Ji-Hun Jang, Joon-Suk Oh, Min-Kyung Park, Cheol-Hyun Kim, Jun Sun, Sang-Moo Kang. Heat-killed Lactobacillus casei confers broad protection against influenza A virus primary infection and develops heterosubtypic immunity against future secondary infectionScientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-17487-8

Aura Raulo, Lasse Ruokolainen, Avery Lane, Katherine Amato, Rob Knight, Steven Leigh, Rebecca Stumpf, Bryan White, Karen E. Nelson, Andrea L. Baden, Stacey R. Tecot. Social behaviour and gut microbiota in red-bellied lemurs (Eulemur rubriventer): In search of the role of immunity in the evolution of socialityJournal of Animal Ecology, 2017; DOI: 10.1111/1365-2656.12781

Corticotropin-releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress-induced pathophysiology.

Ayyadurai S, Gibson AJ, D’Costa S, Overman EL, Sommerville LJ, Poopal AC, Mackey E, Li Y, Moeser AJ. J Leukoc Biol. 2017 Dec;102(6):1299-1312. doi: 10.1189/jlb.2HI0317-088RR.

Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide.

Gulledge TV1, Collette NM1, Mackey E2, Johnstone SE1, Moazami Y3, Todd DA4, Moeser AJ2, Pierce JG5, Cech NB4, Laster SM6. J Ethnopharmacol. 2018 Feb 15;212:166-174. doi: 10.1016/j.jep.2017.10.012. Epub 2017 Oct 14.

Evilena Anastasiou, Anastasia Papathanasiou, Lynne A. Schepartz, Piers D. Mitchell. Infectious disease in the ancient Aegean: Intestinal parasitic worms in the Neolithic to Roman Period inhabitants of Kea, GreeceJournal of Archaeological Science: Reports, 2017; DOI: 10.1016/j.jasrep.2017.11.006

Catherine Vilchèze, John Kim, William R. Jacobs. Vitamin C potentiates the killing of Mycobacterium tuberculosis by the first-line tuberculosis drugs isoniazid and rifampicin in miceAntimicrobial Agents and Chemotherapy, 2018; AAC.02165-17 DOI: 10.1128/AAC.02165-17

January 2018

NEWS

Lean, Michael EJ et al. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. The Lancet, 5 December 2017. DOI: http://dx.doi.org/10.1016/S0140-6736(17)33102-1

Elisabetta Lauretti, Domenico Pratic�. Effect of canola oil consumption on memory, synapse and neuropathology in the triple transgenic mouse model of Alzheimer’s diseaseScientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-17373-3

Monica E. Embers, Nicole R. Hasenkampf, Mary B. Jacobs, Amanda C. Tardo, Lara A. Doyle-Meyers, Mario T. Philipp, Emir Hodzic. Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feedingPLOS ONE, 2017; 12 (12): e0189071 DOI: 10.1371/journal.pone.0189071

Nicholas A. Crossland, Xavier Alvarez, Monica E. Embers. Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Post-Treatment in Rhesus MacaquesThe American Journal of Pathology, 2017; DOI: 10.1016/j.ajpath.2017.11.005

J Public Health Policy. 2017 Nov 27. doi: 10.1057/s41271-017-0095-7. [Epub ahead of print]. Complexity and conflicts of interest statements: a case-study of emails exchanged between Coca-Cola and the principal investigators of the International Study of Childhood Obesity, Lifestyle and the Environment (ISCOLE).

Stuckler D1, Ruskin G2, McKee M3. Open Access: https://link.springer.com/article/10.1057%2Fs41271-017-0095-7.

JOINTS and BONES

Louisa E. Jeffery, Peter Henley, Nefisa Marium, Andrew Filer, David M. Sansom, Martin Hewison, Karim Raza. Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid jointJournal of Autoimmunity, 2017; DOI: 10.1016/j.jaut.2017.10.001

Shweta Khanna, Kumar Sagar Jaiswal, Bhawna Gupta. Managing Rheumatoid Arthritis with Dietary InterventionsFrontiers in Nutrition, 2017; 4 DOI: 10.3389/fnut.2017.00052

  1. Loukov, S. Karampatos, M.R. Maly, D.M.E. Bowdish. Monocyte activation is elevated in women with knee-osteoarthritis and associated with inflammation, BMI and painOsteoarthritis and Cartilage, 2017; DOI: 10.1016/j.joca.2017.10.018

Diddier Prada, Jia Zhong, Elena Colicino, Antonella Zanobetti, Joel Schwartz, Nicholas Dagincourt, Shona C Fang, Itai Kloog, Joseph M Zmuda, Michael Holick, Luis A Herrera, Lifang Hou, Francesca Dominici, Benedetta Bartali, Andrea A Baccarelli. Association of air particulate pollution with bone loss over time and bone fracture risk: analysis of data from two independent studiesThe Lancet Planetary Health, 2017; 1 (8): e337 DOI: 10.1016/S2542-5196(17)30136-5

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3503-3508. doi: 10.1073/pnas.1618545114. Epub 2017 Mar 13.

B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial.

Zhong J1, Karlsson O2,3, Wang G4, Li J5,6, Guo Y7, Lin X8, Zemplenyi M7, Sanchez-Guerra M9, Trevisi L10, Urch B11,12,13,14, Speck M11, Liang L7, Coull BA7, Koutrakis P10, Silverman F11,12,13,14, Gold DR10,15, Wu T5,6, Baccarelli AA16.

A.A. Macintosh et al. Prehistoric women’s manual labor exceeded that of athletes through the first 5500 years of farming in Central EuropeScience Advances, 2017 DOI: 10.1126/sciadv.aao3893

 

Omar Al Rifai, Jacqueline Chow, Julie Lacombe, Catherine Julien, Denis Faubert, Delia Susan-Resiga, Rachid Essalmani, John W.M. Creemers, Nabil G. Seidah, Mathieu Ferron. Proprotein convertase furin regulates osteocalcin and bone endocrine functionJournal of Clinical Investigation, 2017; 127 (11): 4104 DOI: 10.1172/JCI93437

K2
1 Buitenhuis HC et al. Biochim Biophys Acta. 1990;1034:170-175.

2 Knapen MH et al. Osteoporos Int. 2013 Sep;24(9):2499-507.

3 Knapen MH et al. Thrombosis and Haemostasis. 2015; 19;113(5).

4 J Nutr Sci. 2015; 4: e35. Published online 2015 Oct 16. doi:  10.1017/jns.2015.25

PMCID: PMC4611080. Yogurt drink fortified with menaquinone-7 improves vitamin K status in a healthy population

Marjo H. J. Knapen,1 Lavienja A. J. L. M. Braam,1 Kirsten J. Teunissen,1 Renate M. L. Zwijsen,2 Elke Theuwissen,1 andCees Vermeer1,*

5 Cummings SR et al. Lancet.1993 Jan 9;341(8837):72–5.

6 Shea MK et al. J Nutr. 2011 Aug;141(8):1529-34.

7 Theuwissen E et al. Food & Function 2014 The Royal Society of Chemistry.

8 van Summeren MJH et al. Br J Nutr. 2009; 102(8):1171-8.

AUTOIMMUNITY – Dr Andrew Campbell

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  14. Hamza H, Cao J, Li X, Li C, Zhu M, Zhao S. Hepatitis B vaccine induces apoptotic death in Hepa1-6 cells. Apoptosis. 2012;17:516–527. [PubMed]
  15. Strassburg CP, Vogel A, Manns MP. Autoimmunity and hepatitis C. Autoimmunity Reviews. 2003;2(6):322–331. [PubMed]
  16. Palazzi C, Buskila D, D’Angelo S, D’Amico E, Olivieri I. Autoantibodies in patients with chronic hepatitis C virus infection: pitfalls for the diagnosis of rheumatic diseases. Autoimmunity Reviews. 2012;11(9):659–663. [PubMed]
  17. Cohen-Tervaert JW, Kappel RM. Siliconeimplantincompatibilitysyndrome (SIIS): afrequentcauseofASIA(Shoenfeld’ssyndrome) Immunologic Research. 2013;56:293–298. [PubMed]
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  19. Klareskog L, Stolt P, Lundberg K, et al. A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis and Rheumatism. 2006;54(1):38–46. [PubMed]
  20. Schellekens GA, Visser H, de Jong BA. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis & Rheumatology. 2000;43(1):155–163. [PubMed]
  21. Kivity S, Agmon-Levin N, Blank M, Shoenfeld Y. Infections and autoimmunity: friends or foes? Trends in Immunology. 2009;30(8):409–414. [PubMed]
  22. Davies TF. Infection and autoimmune thyroid disease. Journal of Clinical Endocrinology and Metabolism. 2008;93(3):674–676.[PubMed]
  23. James JA, Neas BR, Moser KL, et al. Systemic lupus erythematosus in adults is associated with previous Epstein-Barr virus exposure. Arthritis and Rheumatism. 2001;44:1122–1126. [PubMed]
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RESEARCH
Romy Conzade, Wolfgang Koenig, Margit Heier, Andrea Schneider, Eva Grill, Annette Peters, Barbara Thorand. Prevalence and Predictors of Subclinical Micronutrient Deficiency in German Older Adults: Results from the Population-Based KORA-Age StudyNutrients, 2017; 9 (12): 1276 DOI: 10.3390/nu9121276.

Yftach Gepner et al. Effect of Distinct Lifestyle Interventions on Mobilization of Fat Storage Pools: The CENTRAL MRI Randomized Controlled TrialCirculation, 2017; CIRCULATIONAHA.117.030501 DOI: 10.1161/CIRCULATIONAHA.117.030501

NEW RELEASES

Kass L, et al. Effect of transdermal magnesium cream on serum and urinary magnesium levels in humans: A pilot study. PLOS One 2017: https://doi.org/10.1371/journal.pone.0174817

December 2017

IHCAN December 2017 references

NEWS

Renzi-Hammond LM, Bovier ER, et al. Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized, Double-Masked, Placebo-Controlled Trial of Younger Healthy Adults. Nutrients. 2017 November 14;9(11). pii: E1246. doi: 10.3390/nu9111246.

The associations of serum n-6 polyunsaturated fatty acids with serum C-reactive protein in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Jyrki K. Virtanen, Jaakko Mursu, Sari Voutilainen, Tomi-Pekka Tuomainen .
European Journal of Clinical Nutrition, published online 6.11.2017
doi:10.1038/s41430-017-0009-6
https://www.nature.com/articles/s41430-017-0009-6

Monti D et al. Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer. Seminars in Oncology 2017: http://www.seminoncol.org/article/S0093-7754(17)30136-7/fulltext

Experiences of healing therapy in patients with irritable bowel syndrome and inflammatory bowel disease. Andrew Soundy et al. BMC Complementary and Alternative Medicine 2015, 15:106: https://doi.org/10.1186/s12906-015-0611-x
Main, quantitative paper:
http://www.sciencedirect.com/science/article/pii/S187638201630422X
Secondary, qualitative paper:
https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-015-0611-x.

Joseph L. Dieleman, PhD. Factors Associated With Increases in US Health Care Spending, 1996-2013. JAMA, November 2017 DOI: 10.1001/jama.2017.15927

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47. Spence JD, Thornton T, Muir AD, Westcott ND. The effect of flax seed cultivars with differing content of alpha-linolenic acid and lignans on responses to mental stress. J Am Coll Nutr. 2003 Dec;22(6):494-501.
48. Barbadoro P, Annino I, Ponzio E, Romanelli RM, D’Errico MM, Prospero E, Minelli A. Fish oil supplementation reduces cortisol basal levels and perceived stress: a randomized, placebo-controlled trial in abstinent alcoholics. Mol Nutr Food Res. 2013 Jun;57(6):1110-4.
49. Kato-Kataoka A, Nishida K, Takada M, Suda K, Kawai M, Shimizu K, Kushiro A, Hoshi R, Watanabe O, Igarashi T, Miyazaki K, Kuwano Y, Rokutan K. Fermented milk containing Lactobacillus casei strain Shirota prevents the onset of physical symptoms in medical students under academic examination stress. Benef Microbes. 2016;7(2):153-6.
50. Klein LC, Bennett JM, Whetzel CA, Granger DA, Ritter FE. Caffeine and stress alter salivary alpha-amylase activity in young men. Hum Psychopharmacol. 2010 Jul;25(5):359-67.
51. Lane JD, Pieper CF, Phillips-Bute BG, Bryant JE, Kuhn CM. Caffeine affects cardiovascular and neuroendocrine activation at work and home. Psychosom Med. 2002 Jul-Aug;64(4):595-603.
52. Lovallo WR, Whitsett TL, al’Absi M, Sung BH, Vincent AS, Wilson MF. Caffeine stimulation of cortisol secretion across the waking hours in relation to caffeine intake levels. Psychosom Med. 2005 Sep-Oct;67(5):734-9.
53. Lovallo WR, Al’Absi M, Blick K, Whitsett TL, Wilson MF. Stress-like adrenocorticotropin responses to caffeine in young healthy men. Pharmacol Biochem Behav. 1996 Nov;55(3):365-9.
54. Klein LC, Whetzel CA, Bennett JM, Ritter FE, Nater UM, Schoelles M. Caffeine administration does not alter salivary α-amylase activity in young male daily caffeine consumers. BMC Res Notes. 2014 Jan 13;7:30.
55. Lovallo WR, Farag NH, Vincent AS, Thomas TL, Wilson MF. Cortisol responses to mental stress, exercise, and meals following caffeine intake in men and women. Pharmacol Biochem Behav. 2006 Mar;83(3):441-7.
56. MacKenzie T, Comi R, Sluss P, Keisari R, Manwar S, Kim J, Larson R, Baron JA. Metabolic and hormonal effects of caffeine: randomized, double-blind, placebo-controlled crossover trial. Metabolism. 2007 Dec;56(12):1694-8.
57. Gavrieli A, Yannakoulia M, Fragopoulou E, Margaritopoulos D, Chamberland JP, Kaisari P, Kavouras SA, Mantzoros CS. Caffeinated coffee does not acutely affect energy intake, appetite, or inflammation but prevents serum cortisol concentrations from falling in healthy men. J Nutr. 2011 Apr 1;141(4):703-7.
58. Papakonstantinou E, Kechribari I, Sotirakoglou Κ, Tarantilis P, Gourdomichali T, Michas G, Kravvariti V, Voumvourakis K, Zampelas A. Acute effects of coffee consumption on self-reported gastrointestinal symptoms, blood pressure and stress indices in healthy individuals. Nutr J. 2016 Mar 15;15:26.
59. Steptoe A, Gibson EL, Vuononvirta R, Williams ED, Hamer M, Rycroft JA, Erusalimsky JD, Wardle J. The effects of tea on psychophysiological stress responsivity and post-stress recovery: a randomised double-blind trial. Psychopharmacology.(Berl) 2007 Jan;190(1):81-9.
60. Haskell CF, Dodd FL, Wightman EL, Kennedy DO. Behavioural effects of compounds co-consumed in dietary forms of caffeinated plants. Nutr Res Rev. 2013 Jun;26(1):49-70.
61. Lara DR. Caffeine, mental health, and psychiatric disorders. J Alzheimers Dis. 2010;20 Suppl 1:S239-48.

62. Johnstone AM, Faber P, Andrew R, Gibney ER, Elia M, Lobley G, Stubbs RJ, Walker BR. Influence of short-term dietary weight loss on cortisol secretion and metabolism in obese men. Eur J Endocrinol. 2004 Feb;150(2):185-94.

STRESS – Catalina Fernández de Ana Portela

1. Suzanne C. Segerstrom and Gregory E. Miller, Psychological Stress and the Human Immune System: A Meta-Analytic Study of 30 Years of Inquiry, Psychol Bull. Author manuscript; available in PMC Feb 7, 2006.
2. The effects of β-glucan on human immune and cancer cells, Godfrey Chi-Fung Chan, Wing Keung Chan and Daniel Man-Yuen Sze. Journal of Hematology & Oncology2009, 2:25. https://doi.org/10.1186/1756-8722-2-25.
3. Zimmerman RS1, Frohlich ED. Stress and hypertension. J Hypertens Suppl. 1990 Sep;8(4):S103-7.
4. Annika Rosengren et al. Association of psychosocial risk factors with risk of acute myocardial infarction in 11 119 cases and 13 648 controls from 52 countries (the INTERHEART study): case-control study. The Lancet 2004, Volume 364, Issue 9438, 11–17 September, 953-962.
5. Su, C.Y., Shiao, M.S., and Wang, C.T., Predominant inhibition of ganodermic acid S on the thromboxane A2-dependent pathway in human platelets response to collagen, Biochim. Biophys. Acta, 1437, 223–234, 1999.
6. Komoda, Y. et al. 1989. Ganoderic Acid and Its Derivatives as Cholesterol Synthesis Inhibitors. Chem. Pharm. Bull. 37(2): 531-533.
7. Shu-Ting Chang and John Buswell. Ganoderma lucidum (Curt.: Fr.) P. Karst. (Aphyllophoromycetideae)−A Mushrooming Medicinal Mushroom. Int J Medicinal Mushrooms 1999, v1.i2.30, 139-146. DOI: 10.1615/IntJMedMushrooms.
8. Tsuno A, Taketomo N, Hiroyuki I. Healthful composition obtained from the hot water extract of Cordyceps sinensis mycelia. J Lab Clin Med 1995, 8:134–7.
9. I.J. Elenkov. Glucocorticoids and the Th1/Th2 balance. Ann. N. Y. Acad. Sci 2004, 1024, 138-146.
10. Hadj-Kacem H et al. Autoimmune thyroid diseases: genetic susceptibility of thyroid-specific genes and thyroid autoantigens contributions. Int J Immunogenet 2009, Apr; 36(2):85-96. doi: 10.1111/j.1744-313X.2009.00830.x.
11. Falgarone G, et al. Mechanisms in endocrinology. Role of emotional stress in the pathophysiology of Graves’ disease. Eur J Endocrinol 2013.
12. S.-Y. Wang, M.-L. Hsu, and H.-C. Hsu. The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. International Journal of Cancer 1997, vol. 70, no. 6, pp. 699–705.
13. JH Koh, et al., Antifatigue and Anti-stress Effect of the Hot-Water Fraction from Mycelia of Cordyceps sinensis. Biol. Pharm. Bull 2003, 26 (5), 691–4.
14. Rossi P et al. Improving Training Condition Assessment in Endurance Cyclists: Effects of Ganoderma lucidum and Ophiocordyceps sinensis Dietary Supplementation. Evid Based Complement Alt Med 2014, 979613.DOI: 10.1155/2014/979613. Epub 2014 Apr 1.
15. Akinobu Tsunoo et al, Meiji institute of Health Science. Cordyceps Sinensis: Its diverse effects on mammals in vitro and in vivo. Third International Symposium of the Mycological Society of Japan, 1995.
16. Guowei Dai, Tiantong Bao, Changfu Xu, Raymond Cooper, and Jia-Shi Zhu. CordyMax™ Cs-4 Improves Steady-State Bioenergy Status in Mouse Liver.
JACM 2004, July, 7(3): 231-240. https://doi.org/10.1089/107555301300328106
17. Holm JE, Lamberty K, McSherry WC 2nd, Davis PA The stress response in headache sufferers: physiological and psychological reactivity. Headache 1997, Apr;37(4):221-7.
18. Fukui PT et al. Trigger factors in migraine patients. Arq Neuropsiquiatr 2008, Sep; 66(3A):494-9.
19. Sun T-F et al. Mindfulness meditation in the control of severe headache. Chang Gung Med J, 2002, 25, 8.
20. Yi Liu, Jihui Wang. The Chemical Constituents and Pharmacological Actions of Cordyceps sinensis. Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 575063, https://www.hindawi.com/journals/ecam/2015/575063.
21. Nagano et al.. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Research 2010, 31, 231-237.
22. Lee J. M, Kwon H, Jeong H, editors. et al. Inhibition of lipid peroxidation and oxidative DNA damage by Ganoderma lucidum. Phytother Res 2001, 15:245–9.
23. Ji DB et al. Phytother Res 2009, Jan, 23(1):116-22. doi: 10.1002/ptr.2576.
Antiaging effect of Cordyceps sinensis extract.
24. Dancey CP, Taghavi M, Fox RJ. The relationship between daily stress and symptoms of irritable bowel: a time-series approach. J Psychosom Res 1998, May;44(5):537-45.
25. Shaw G et al. Stress management for irritable bowel syndrome: a controlled trial.
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26. Koh J. H, Suh H. J, Ahn T. Hot-water extract from mycelia of Cordyceps sinensis as a substitute for antibiotic growth promoters. Biotechnol Lett 2003a, 25:585–90.
27. Macpherson AJ, Marrinic MM, Harris N. The functions of mucosal T-cells in containing the indigenous commensal flora of the intestine. Cell Mol Life Sci 2002, 59:2088–96.

NUTRIGENOMICS – Bernie Williams
References:
I. Hara K et al., The Pro12Ala Polymorphism in PPAR𝛾2 may confer resistance to type 2 diabetes. Biochem Biophys. Res. Comm. (2000) 29:212-216
II. Stefan N. et al., Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 gene. Diabetes. (2001) 50:1143–1148
III. Vaquero AR et al. Using gene-network landscape to dissect genotype effects of TCF7L2 genetic variant on diabetes and cardiovascular risk. Physiol. Genomics. (2012) 44:903–14
IV. Shaffer S A et al. Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 gene polymorphisms. Diabetes. (2007)12: 2443-50
V. Grant S et al. Variant of Transcription factor 7-like 2 gene confers risk of type 2 diabetes. Nature. (2006) 38: 320-323
VI. Scheller J et al., The pro-and-anti-inflammatory properties of the cytokine interleukin-6. Biochim et Biophys Acta – Mol Cell Res. (2011) 1813:5 878-888
VII. Ligthart S et al., DNA methylation signatures of chronic low grade inflammation are associated with complex diseases. (2016) Genome Biology 17:255
VIII. Brustolin S et al., Genetics of homocysteine metabolism and associated disorders. Braz J Med Biol Res (2010) 43:1-7
IX. Lim U & Song M, Dietary and Lifestyle Factors of DNA methylation. Cancer Epigenetics (2012) 863:359-376
X. Bokor S et al., Single nucleotide polymorphism in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios. Journal of Lipid Research (2010) 51:2325-33.
XI. Vessby B et al,. Desaturation and elongation of Fatty acids and insulin action. Ann N Y Acad Sci. (2002) 967:183-95.
XII. Leffler D et al., Extraintestinal manifestations of coeliac disease. Nat. Rev. Gastroenterol.Hepatol. (2015) 12: 561-571
XIII. Monsuur et al., Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms. PLoS ONE. (2008) 3:e2270
XIV. Withoff S, et al., Understanding celiac disease by genomics. Trends in Genetics. (2016) 32:295-308.

FRONTIERS – Simon Mills
Aggarwal BB.(2004) Nuclear factor-kappaB: the enemy within. Cancer Cell 6(3): 203-208.
Barnard RJ, Aronson WJ. (2009) Benign prostatic hyperplasia: does lifestyle play a role? Phys Sportsmed 37(4): 141-146.
Barry MJ, Meleth S, Lee JY, et al (2011). Effect of increasing doses of saw palmetto extract on lower urinary tract symptoms: a randomized trial. Complementary and Alternative Medicine for Urological Symptoms (CAMUS) Study Group. JAMA. 306(12):1344-51.
Bombardelli E, Morazzoni P. (1997) Cucurbita pepo L. Fitoterapia 68(4): 291-302.
Bone K, Mills S. (2013) Principles and Practice of Phytotherapy; 2nd Edition. Churchill Livingstone, Edinburgh
Capodice JL, Gorroochurn P, Cammack S et al. (2009) Zyflamend in men with high-grade prostatic intraepithelial neoplasia: results of a phase I clinical trial. J Soc Integr Oncol 7(2): 43-51.
Demark-Wahnefried W, Polascik TJ, George SL et al. (2008) Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery. Cancer Epidemiol Biomarkers Prev 17(12): 3577-3587.
Freedland SJ, Aronson WJ. (2009) Dietary intervention strategies to modulate prostate cancer risk and prognosis. Curr Opin Urol 19(3): 263-267.
Gardner CD, Oelrich B, Liu JP et al. (2009) Prostatic soy isoflavone concentrations exceed serum levels after dietary supplementation. Prostate 69(7): 719-726.
Jacobs EJ, Rodriguez C, Mondul AM et al. (2005) A large cohort study of aspirin and other nonsteroidal anti-inflammatory drugs and prostate cancer incidence. J Natl Cancer Inst 97(13): 975-980.
John H, Barghorn A, Funke G et al. (2001) Noninflammatory chronic pelvic pain syndrome: immunological study in blood, ejaculate and prostate tissue. Eur Urol 39(1): 72-78.
Kell JS. (2010) Prostate-specific antigen tests and prostate cancer screening: an update for primary care physicians. Can J Urol 17(Suppl 1): 18-25.
Kramer G, Mitteregger D, Marberger M (2007). Is benign prostatic hyperplasia (BPH) an immune inflammatory disease? Eur Urol 51(5): 1202-1216.
Krieger JN. (2004) Classification, epidemiology and implications of chronic prostatitis in North America, Europe and Asia. Minerva Urol Nefrol 56(2): 99-107.
McCann MJ, Gill CI, Linton T et al. (2008) Enterolactone restricts the proliferation of the LNCaP human prostate cancer cell line in vitro. Mol Nutr Food Res 52(5): 567-580.
Mehik A, Hellstrom P, Sarpola A et al. (2001) Fears, sexual disturbances and personality features in men with prostatitis: a population-based cross-sectional study in Finland. BJU Int 88(1): g35-38.
Mills S. (2001) Benign prostatic disease: herbal approaches in Boyd & Hamilton-Stewart eds. Key advances in the effective management of benign prostatic disease. Journal of the Royal Society of Medicine, London. 35-40
Moul S, McVary KT. (2010) Lower urinary tract symptoms, obesity and the metabolic syndrome. Curr Opin Urol 20(1): 7-12.
Parsons JK, Im R. (2009) Alcohol consumption is associated with a decreased risk of benign prostatic hyperplasia. J Urol 182(4): 1463-1468.
Parsons JK, Sarma AV, McVary K et al. (2009) Obesity and benign prostatic hyperplasia: clinical connections, emerging etiological paradigms and future directions. J Urol 182(6 Suppl): S27-S31.
Parsons JK. (2007) Modifiable risk factors for benign prostatic hyperplasia and lower urinary tract symptoms: new approaches to old problems. J Urol 178(2): 395-401.
Patel AR, Klein EA. (2009) Risk factors for prostate cancer. Nat Clin Pract Urology 6(2): 87-95.
Ranjan P, Dalela D, Sankhwar SN. (2006) Diet and benign prostatic hyperplasia: implications for prevention. Urology 68(3): 470-476.
Roehrbornb CG (2008). Pathology of benign prostatic hyperplasia. Int J Impot Res 20(Suppl 3): S11-S18.
Safarinejad MR. (2005) Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. J Herbal Pharmacother 5(4): 1-11.
Sarma AV, Kellogg Parsons J. (2009) Diabetes and benign prostatic hyperplasia: emerging clinical connections. Curr Urol Rep 10(4): 267-275.
Sarma AV, Parsons JK, McVary K et al. (2009) Diabetes and benign prostatic hyperplasia/lower urinary tract symptoms-what do we know? J Urol 182(6 Suppl): S32-S37.
Schoonen WM, Salinas CA, Kiemeney LALM et al. (2005) Alcohol consumption and risk of prostate cancer in middle-aged men. Int J Cancer 113(1): 133-140.
Sciarra A, Mariotti G, Salciccia S et al. (2008) Prostate growth and inflammation. J Steroid Biochem Mol Biol 108(3-5): 254-260.
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Singh RP, Tyagi AK, Dhanalakshmi S et al. (2004) Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3. Int J Cancer 108(5): 733-740.
Tacklind J, MacDonald R, Rutks I, Wilt TJ. (2009) Serenoa repens for benign prostatic hyperplasia. Cochrane Database Syst Rev. CD001423.
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Vikram A, Jena G, Ramarao P. (2010) Insulin-resistance and benign prostatic hyperplasia: the connection. Eur J Pharmacol 641(2-3): 75-81.
Wilt T, Ishani A, MacDonald R. (2002) Serenoa repens for benign prostatic hyperplasia. Cochrane Database Syst Rev CD001423.
Yan L, Spitznagel EL. (2009) Soy consumption and prostate cancer risk in men: a revisit of a meta-analysis. Am J Clin Nutr 89(4): 1155-1163.
Yassin AA, El-Sakka AI, Saad F et al. (2008) Lower urinary-tract symptoms and testosterone in elderly men. World J Urol 26(4): 359-364.

IN PRACTICE – Daniela Lawler.

Atkinson, W et al 2004. Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial. Gut, 53 Pp: 1391-1393. http://gut.bmj.com/content/53/10/1459.short.
Cantorna, M. Mahon, B. 2004. Mounting Evidence for Vitamin D as an Environmental Factor Affecting Autoimmune Disease Prevalence. EBM, 229(11). http://journals.sagepub.com/doi/pdf/10.1177/153537020422901108.
Heitzer, T et al 2001. Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients with Coronary Artery Disease. Circulation, 104 Pp: 2673-2678. June 2017. http://circ.ahajournals.org/content/104/22/2673?download=true.
Hyde, J. (2015). The Gut Makeover. (Great Britain. Quercus).
Kharrazian, D (2010). Why Do I Still Have Thyroid Symptoms?. (California. Elephant Press) p25, 31.
Lewis, C. (2016). Enteroimmunology. 3rd ed (Carrabelle Florida. PsyPress), p246.
Liblau, R. 1995. Th1 and Th2 CD4+ T cells in the pathogenesis of organ specific autoimmune disease. Immunology Today, 16(1). Pp: 34-38. http://www.sciencedirect.com/science/article/pii/0167569995800689.

RESEARCH

Chunxu Gao, Bhanu Priya Ganesh, Zhongcheng Shi, Rajesh Rasik Shah, Robert Fultz, Angela Major, Susan Venable, Monica Lugo, Kathleen Hoch, Xiaowei Chen, Anthony Haag, Timothy C. Wang, James Versalovic. Gut Microbe–Mediated Suppression of Inflammation-Associated Colon Carcinogenesis by Luminal Histamine Production. The American Journal of Pathology, 2017; DOI: 10.1016/j.ajpath.2017.06.011

Lori D’Ortenzio, Isabelle Ribot, Bonnie Kahlon, Benoit Bertrand, Emmy Bocaege, Emeline Raguin, Annabelle Schattmann, Megan Brickley. The rachitic tooth: The use of radiographs as a screening technique. International Journal of Paleopathology, 2017; DOI: 10.1016/j.ijpp.2017.10.001

Haris Majeed, G. W. K. Moore. Impact of Multidecadal Climate Variability on United Kingdom Rickets Rates. Scientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-16058-1
Francesca Romana Mancini, Aurélie Affret, Courtney Dow, Beverley Balkau, Fabrice Bonnet, Marie-Christine Boutron-Ruault, Guy Fagherazzi. Dietary antioxidant capacity and risk of type 2 diabetes in the large prospective E3N-EPIC cohort. Diabetologia, 2017; DOI: 10.1007/s00125-017-4489-7

Nicola Wilck et al. Salt-responsive gut commensal modulates TH17 axis and disease. Nature, 2017; DOI: 10.1038/nature24628

November 2017

NEWS
Joseph Jamnik, Christopher R Villa, Sirbarinder Bryn Dhir, David J A Jenkins, Ahmed El-Sohemy. Prevalence of positive coeliac disease serology and HLA risk genotypes in a multiethnic population of adults in Canada: a cross-sectional study. BMJ Open, 2017; 7 (10): bmjopen-2017-017678 DOI: 10.1136/bmjopen-2017-017678.

Luke T. Stewart, Anas U. Khan, Kai Wang, Diana Pizarro, Sandipan Pati, Susan C. Buckingham, Michelle L. Olsen, John C. Chatham, Lori L. McMahon. Acute Increases in Protein O-GlcNAcylation Dampen Epileptiform Activity in Hippocampus. The Journal of Neuroscience, 2017; 37 (34): 8207 DOI: 10.1523/JNEUROSCI.0173-16.2017.

Ken-ichi Kudo, Tadashi Hanafusa and Toshiro Ono.  In vitro analysis of radioprotective effect of monoterpenes. J Radioanal Nucl Chem (2017) 313: 169.
DOI: https://doi.org/10.1007/s10967-017-5268-0.
https://link.springer.com/article/10.1007/s10967-017-5268-0.

Laura M. Kemppainen, Teemu T. Kemppainen, Jutta A. Reippainen, Suvi T. Salmenniemi, Pia H. Vuolanto. Use of complementary and alternative medicine in Europe: Health-related and sociodemographic determinants. Scandinavian Journal of Public Health, 2017; 140349481773386 DOI: 10.1177/1403494817733869.

Olga Bednarska, Susanna A. Walter, Maite Casado-Bedmar, Magnus Ström, Eloísa Salvo-Romero, Maria Vicario, Emeran A. Mayer, Åsa V Keita. VIP and Mast Cells Regulate Increased Passage of Colonic Bacteria in Patients With Irritable Bowel Syndrome. Gastroenterology, 2017; DOI: 10.1053/j.gastro.2017.06.051

BEN BROWN – Nickel

1.             Schram SE, Warshaw EM, Laumann A. Nickel hypersensitivity: a clinical review and call to action. Int J Dermatol. 2010 Feb;49(2):115-25.2.             Yoshihisa Y, Shimizu T. Metal allergy and systemic contact dermatitis: an overview. Dermatol Res Pract. 2012;2012:749561.3.             Torres F, das Graças M, Melo M, Tosti A. Management of contact dermatitis due to nickel allergy: an update. Clin Cosmet Investig Dermatol. 2009 Apr 17;2:39-48.4.             Sharma AD. Relationship between nickel allergy and diet. Indian J Dermatol Venereol Leprol. 2007 Sep-Oct;73(5):307-12.5.             Jensen CS, Menné T, Lisby S, Kristiansen J, Veien NK. Experimental systemic contact dermatitis from nickel: a dose-response study. Contact Dermatitis. 2003 Sep;49(3):124-32.6.             Ysart G, Miller P, Crews H, Robb P, Baxter M, De L’Argy C, Lofthouse S, Sargent C, Harrison N. Dietary exposure estimates of 30 elements from the UK Total Diet Study. Food Addit Contam. 1999 Sep;16(9):391-403. 7.             Krecisz B, Chomiczewska D, Kiec-Swierczynska M, Kaszuba A. Systemic contact dermatitis to nickel present in cocoa in 14-year-old boy. Pediatr Dermatol. 2011 May-Jun;28(3):335-6. 8.             Silvestri DL, Barmettler S. Pruritus ani as a manifestation of systemic contact dermatitis: resolution with dietary nickel restriction. Dermatitis. 2011  Jan-Feb;22(1):50-5.

  1. Rizzi A, Nucera E, Laterza L, et al. Irritable Bowel Syndrome and Nickel Allergy: What Is the Role of the Low Nickel Diet? J Neurogastroenterol Motil. 2017 Jan 30;23(1):101-108.

10.         Sharma AD. Relationship between nickel allergy and diet. Indian J Dermatol Venereol Leprol. 2007 Sep-Oct;73(5):307-12.11.         Saito M, Arakaki R, Yamada A, Tsunematsu T, Kudo Y, Ishimaru N. Molecular Mechanisms of Nickel Allergy. Int J Mol Sci. 2016 Feb 2;17(2).12.         Minelli M, Schiavino D, Musca F, et al. Oral hyposensitization to nickel induces clinical improvement and a decrease in TH1 and TH2 cytokines in patients with systemic nickel allergy syndrome. Int J Immunopathol Pharmacol. 2010 Jan-Mar;23(1):193-201.

  1. Picarelli A, Di Tola M, Vallecoccia A, Libanori V, Magrelli M, Carlesimo M, et al. Oral mucosa patch test: a new tool to recognize and study the adverse effects of dietary nickel exposure. Biol Trace Elem Res 2011; 139: 151-9.

14.         Braga M, Quecchia C, Perotta C, Timpini A, Maccarinelli K, Di Tommaso L, Di Gioacchino M. Systemic nickel allergy syndrome: nosologic framework and usefulness of diet regimen for diagnosis. Int J Immunopathol Pharmacol. 2013 Jul-Sep;26(3):707-16.15.         Borghini R, Donato G, Alvaro D, Picarelli A. New insights in IBS-like disorders: Pandora’s box has been opened; a review. Gastroenterol Hepatol Bed Bench. 2017 Spring;10(2):79-89.

  1. Tammaro A, De Marco G, Persechino S, Narcisi A, Camplone G. Allergy to nickel: first results on patients administered with an oral hyposensitization therapy. Int J Immunopathol Pharmacol. 2009 Jul-Sep;22(3):837-40.

DIGESTIVE HEALTH update

Roopa Hebbandi Nanjundappa, Francesca Ronchi, Jinguo Wang, Xavier Clemente-Casares, Jun Yamanouchi, Channakeshava Sokke Umeshappa, Yang Yang, Jesús Blanco, Helena Bassolas-Molina, Azucena Salas, Hamza Khan, Robyn M. Slattery, Madeleine Wyss, Catherine Mooser, Andrew J. Macpherson, Laura K. Sycuro, Pau Serra, Derek M. McKay, Kathy D. McCoy, Pere Santamaria. A Gut Microbial Mimic that Hijacks Diabetogenic Autoreactivity to Suppress Colitis. Cell, 2017; 171 (3): 655 DOI: 10.1016/j.cell.2017.09.022

Membrane Lipid Replacement – Mike Ash
[i] Nicolson GL, Ash ME.  Membrane Lipid Replacement for chronic illnesses, aging and cancer using oral glycerolphospholipid formulations with fructooligosaccharides to restore phospholipid function in cellular membranes, organelles, cells and tissues. Biochim. Biophys. Acta  2017; 1859: 1704-1724.  View Full Paper
[ii] Nicolson GL.  Membrane Lipid Replacement: clinical studies using a natural medicine approach to restoring membrane function and improving health.  Intern. J. Clin. Med. 2016; 7: 133-143. View Full Paper
[iii] Nicolson GL, Rosenblatt S, Ferreira de Mattos G, Settineri R, Breeding PC, Ellithorpe RR,  Ash ME.  Clinical uses of Membrane Lipid Replacement supplements in restoring membrane function and reducing fatigue in chronic diseases and cancer.  Discoveries 2016; 4(1): e54. View Full Paper
[iv] Singer, SJ, Nicolson GL The fluid mosaic model of the structure of cell membranes, Science 1972; 175: 720-731. View Abstract
[v] Nicolson GL. The Fluid—Mosaic Model of Membrane Structure: still relevant to understanding the structure, function and dynamics of biological membranes after more than 40 years. Biochim. Biophys. Acta 2014; 1838: 1451-1466. View Full Paper

Rosshart et al. Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance. Cell, 2017 DOI: 10.1016/j.cell.2017.09.016.

Troy D. Hubbard, Iain A. Murray, Robert G. Nichols, Kaitlyn Cassel, Michael Podolsky, Guray Kuzu, Yuan Tian, Phillip Smith, Mary J. Kennett, Andrew D. Patterson, Gary H. Perdew. Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner. Journal of Functional Foods, 2017; 37: 685 DOI: 10.1016/j.jff.2017.08.038.

Christopher L. Hager, Mahmoud A. Ghannoum. The mycobiome: Role in health and disease, and as a potential probiotic target in gastrointestinal disease. Digestive and Liver Disease, 2017; DOI: 10.1016/j.dld.2017.08.025.

Tiffani Alvey Jones, Diane Z. Hernandez, Zoë C. Wong, Anica M. Wandler, Karen Guillemin. The bacterial virulence factor CagA induces microbial dysbiosis that contributes to excessive epithelial cell proliferation in the Drosophila gut. PLOS Pathogens, 2017; 13 (10): e1006631 DOI: 10.1371/journal.ppat.1006631

RESEARCH UPDATE

Dorothy K. Sit, James McGowan, Christopher Wiltrout, Rasim Somer Diler, John (Jesse) Dills, James Luther, Amy Yang, Jody D. Ciolino, Howard Seltman, Stephen R. Wisniewski, Michael Terman, Katherine L. Wisner. Adjunctive Bright Light Therapy for Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Trial. American Journal of Psychiatry, 2017; appi.ajp.2017.1 DOI: 10.1176/appi.ajp.2017.16101200

Xiangyun Zhu et al. Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis. Nutrition & Metabolism 2017,14:60. https://doi.org/10.1186/s12986-017-0217-z.

Kootte et al. Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition. Cell Metabolism, 2017 DOI: 10.1016/j.cmet.2017.09.008

Katherine McGuire, J.Antonio Avina-Zubieta, John M. Esdaile, Mohsen Sadatsafavi, Eric C. Sayre, Michal Abrahamowicz, Diane Lacaille. Risk of Incident Chronic Obstructive Pulmonary Disease (COPD) in Rheumatoid Arthritis: A Population Based Cohort Study. Arthritis Care & Research, 2017; DOI: 10.1002/acr.23410.

Ian J. Wallace et al. Knee osteoarthritis has doubled in prevalence since the mid-20th century PNAS 2017 114 (35) 9332-9336; doi:10.1073/pnas.1703856114

Timothy Heisel, Emmanuel Montassier, Abigail Johnson, Gabriel Al-Ghalith, Yi-Wei Lin, Li-Na Wei, Dan Knights, Cheryl A. Gale. High-Fat Diet Changes Fungal Microbiomes and Interkingdom Relationships in the Murine Gut. mSphere, October 2017 DOI: 10.1128/mSphere.00351-17.

Wendy S White, Yang Zhou, Agatha Crane, Philip Dixon, Frits Quadt, Leonard M Flendrig. Modeling the dose effects of soybean oil in salad dressing on carotenoid and fat-soluble vitamin bioavailability in salad vegetables. The American Journal of Clinical Nutrition, 2017; 106 (4): 1041 DOI: 10.3945/%u200Bajcn.117.153635

October 2017

IHCAN October references

NEWS

Nisha Rao, Henry A. Spiller, Nichole L. Hodges, Thiphalak Chounthirath, Marcel J. Casavant, Amrit K. Kamboj, Gary A. Smith. An Increase in Dietary Supplement Exposures Reported to US Poison Control Centers. Journal of Medical Toxicology, 2017; DOI: 10.1007/s13181-017-0623-7.

Crawley EM, Gaunt DM, Garfield K, et al. Clinical and cost-effectiveness of the Lightning Process in addition to specialist medical care for paediatric chronic fatigue syndrome: randomised controlled trial. Archives of Disease in Childhood. Published Online First: 20 September 2017. doi: 10.1136/archdischild-2017-313375.

Chunxu Gao, Bhanu Priya Ganesh, Zhongcheng Shi, Rajesh Rasik Shah, Robert Fultz, Angela Major, Susan Venable, Monica Lugo, Kathleen Hoch, Xiaowei Chen, Anthony Haag, Timothy C. Wang, James Versalovic. Gut Microbe–Mediated Suppression of Inflammation-Associated Colon Carcinogenesis by Luminal Histamine Production. The American Journal of Pathology, 2017; DOI: 10.1016/j.ajpath.2017.06.011

NEW RELEASES – migraine

Lidiane Lima Florencio, Anamaria Siriani de Oliveira, Gabriela Ferreira Carvalho, Fabiola Dach, Marcelo Eduardo Bigal, César Fernández-de-las-Peñas, Débora Bevilaqua-Grossi. Association Between Severity of Temporomandibular Disorders and the Frequency of Headache Attacks in Women With Migraine: A Cross-Sectional Study. Journal of Manipulative and Physiological Therapeutics, 2017; 40 (4): 250 DOI: 10.1016/j.jmpt.2017.02.006.

BEN BROWN: Alzheimer’s

 

1.             Beilharz JE, Maniam J, Morris MJ. Diet-Induced Cognitive Deficits: The Role of Fat and Sugar, Potential Mechanisms and Nutritional Interventions. Nutrients. 2015 Aug 12;7(8):6719-38.2.             Petersson SD, Philippou E. Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence. Adv Nutr. 2016 Sep 15;7(5):889-904.3.             McMillan L, Owen L, Kras M, Scholey A. Behavioural effects of a 10-day Mediterranean diet. Results from a pilot study evaluating mood and cognitive performance. Appetite. 2011 Feb;56(1):143-7.

  1. Smith PJ, Blumenthal JA, Babyak MA, Craighead L, Welsh- Bohmer KA, Browndyke JN, et al. Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure. Hypertension 2010;55:1331–8.

5.             Martínez-Lapiscina EH, Clavero P, Toledo E, Estruch R, Salas-Salvadó J, San Julián B, Sanchez-Tainta A, Ros E, Valls-Pedret C, Martinez-Gonzalez MÁ. Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomized trial. J Neurol Neurosurg Psychiatry. 2013 Dec;84(12):1318-25.6.             Valls-Pedret C, Sala-Vila A, Serra-Mir M, Corella D, de la Torre R, Martínez-González MÁ, Martínez-Lapiscina EH, Fitó M, Pérez-Heras A, Salas-Salvadó J, Estruch R, Ros E. Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial. JAMA Intern Med. 2015 Jul;175(7):1094-103.7.             Knight A, Bryan J, Wilson C, Hodgson JM, Davis CR, Murphy KJ. The Mediterranean Diet and Cognitive Function among Healthy Older Adults in a 6-Month Randomised Controlled Trial: The MedLey Study. Nutrients. 2016 Sep 20;8(9).8.             Morris MC, Tangney CC, Wang Y, Sacks FM, Barnes LL, Bennett DA, Aggarwal NT. MIND diet slows cognitive decline with aging. Alzheimers Dement. 2015 Sep;11(9):1015-22.9.             Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT. MIND diet associated with reduced incidence of Alzheimer’s disease. Alzheimers Dement. 2015 Sep;11(9):1007-14.

  1. Morris MC. MIND Diet Intervention and Cognitive Decline (MIND). Accessed on ClinicalTrials.gov on September 15th, 2017.

11.         Bland J. Mild Cognitive Impairment, Neurodegeneration, and Personalized Lifestyle Medicine. Integr Med (Encinitas). 2016 Apr;15(2):12-4.12.         Schelke MW, Hackett K, Chen JL, Shih C, Shum J, Montgomery ME, Chiang GC, Berkowitz C, Seifan A, Krikorian R, Isaacson RS. Nutritional interventions for Alzheimer’s prevention: a clinical precision medicine approach. Ann N Y Acad Sci. 2016 Mar;1367(1):50-6.13.         Bredesen DE. Reversal of cognitive decline: a novel therapeutic program. Aging (Albany NY). 2014 Sep;6(9):707-17. 14.         Bredesen DE, Amos EC, Canick J, Ackerley M, Raji C, Fiala M, Ahdidan J. Reversal of cognitive decline in Alzheimer’s disease. Aging (Albany NY). 2016 Jun;8(6):1250-8.15.         Koppel SJ, Swerdlow RH. Neuroketotherapeutics: A modern review of a century-old therapy. Neurochem Int. 2017 Jun 1. pii: S0197-0186(17)30227-9.16.         Cunnane SC, Courchesne-Loyer A, St-Pierre V, Vandenberghe C, Pierotti T, Fortier M, Croteau E, Castellano CA. Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer’s disease. Ann N Y Acad Sci. 2016 Mar;1367(1):12-20.17.         Yin JX, Maalouf M, Han P, Zhao M, Gao M, Dharshaun T, Ryan C, Whitelegge J, Wu J, Eisenberg D, Reiman EM, Schweizer FE, Shi J. Ketones block amyloid entry and improve cognition in an Alzheimer’s model. Neurobiol Aging. 2016 Mar;39:25-37.18.         Bough KJ, Wetherington J, Hassel B, Pare JF, Gawryluk JW, Greene JG, Shaw R, Smith Y, Geiger JD, Dingledine RJ. Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet. Ann Neurol. 2006 Aug;60(2):223-35.19.         Yang X, Cheng B. Neuroprotective and anti-inflammatory activities of ketogenic diet on MPTP-induced neurotoxicity. J Mol Neurosci. 2010 Oct;42(2):145-53.20.         Krikorian R, Shidler MD, Dangelo K, Couch SC, Benoit SC, Clegg DJ. Dietary ketosis enhances memory in mild cognitive impairment. Neurobiol Aging. 2012

  1. Henderson ST, Vogel JL, Barr L, Garvin F, Jones JJ, Costantini LG. Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer’s disease: a randomized, double-blind, placebo-controlled, multicenter trial. Nutrition & Metabolism. 2009;6:31.

22.         Maynard SD, Gelblum J. Retrospective cohort study of the efficacy of caprylic triglyceride in patients with mild-to-moderate alzheimer’s disease. Neuropsychiatr Dis Treat. 2013;9:1619-27.23.         Farah BA. Effects of caprylic triglyceride on cognitive performance and cerebral glucose metabolism in mild Alzheimer’s disease: a single-case observation. Front Aging Neurosci. 2014 Jul 16;6:133.24.         Ohnuma T, Toda A, Kimoto A, et al. Benefits of use, and tolerance of, medium-chain triglyceride medical food in the management of Japanese patients with Alzheimer’s disease: a prospective, open-label pilot study. Clin Interv Aging. 2016 Jan 8;11:29-36.

  1. Gandotra S, Kour J, Van der Waag A. Efficacy of Adjunctive Extra Virgin Coconut Oil Use in Moderate to Severe Alzheimer’s Disease. Int J Sch Cog Psychol 2014, 1:2

26.         Kapogiannis D, Mattson MP. Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer’s disease. Lancet Neurol. 2011 Feb;10(2):187-98.

  1. Mattson MP. Challenging oneself intermittently to improve health. Dose Response. 2014 Oct 20;12(4):600-18.

28.         Wahl D, Cogger VC, Solon-Biet SM, Waern RV, Gokarn R, Pulpitel T, Cabo Rd, Mattson MP, Raubenheimer D, Simpson SJ, Le Couteur DG. Nutritional strategies to optimise cognitive function in the aging brain. Ageing Res Rev. 2016 Nov;31:80-92.29.         Witte AV, Fobker M, Gellner R, Knecht S, Flöel A. Caloric restriction improves memory in elderly humans. Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1255-60.30.         Martin CK, Anton SD, Han H, York-Crowe E, Redman LM, Ravussin E, Williamson DA. Examination of cognitive function during six months of calorie restriction: results of a randomized controlled trial. Rejuvenation Res. 2007 Jun;10(2):179-90.31.         Scott TM, Rasmussen HM, Chen O, Johnson EJ. Avocado Consumption Increases Macular Pigment Density in Older Adults: A Randomized, Controlled Trial. Nutrients. 2017 Aug 23;9(9). 32.         Krikorian R, Shidler MD, Nash TA, Kalt W, Vinqvist-Tymchuk MR, Shukitt-Hale B, Joseph JA. Blueberry supplementation improves memory in older adults. J Agric Food Chem. 2010 Apr 14;58(7):3996-4000.

  1. Rita Cardoso B, Apolinário D, da Silva Bandeira V, et al. Effects of Brazil nut consumption on selenium status and cognitive performance in older adults with mild cognitive impairment: a randomized controlled pilot trial.Eur J Nutr. 2016 Feb;55(1):107-16.

34.         Kent K, Charlton K, Roodenrys S, et al. Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia. Eur J Nutr. 2017 Feb;56(1):333-341.

  1. Krikorian R, Nash TA, Shidler MD, Shukitt-Hale B, Joseph JA. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr. 2010 Mar;103(5):730-4.

36.         Krikorian R, Boespflug EL, Fleck DE, Stein AL, Wightman JD, Shidler MD, Sadat-Hossieny S. Concord grape juice supplementation and neurocognitive function in human aging. J Agric Food Chem. 2012 Jun 13;60(23):5736-42.37.         Ide K, Yamada H, Takuma N, Park M, Wakamiya N, Nakase J, Ukawa Y, Sagesaka YM. Green tea consumption affects cognitive dysfunction in the elderly: a pilot study. Nutrients. 2014 Sep 29;6(10):4032-42.38.         Parachikova A, Green KN, Hendrix C, LaFerla FM. Formulation of a medical food cocktail for Alzheimer’s disease: beneficial effects on cognition and neuropathology in a mouse model of the disease. PLoS One. 2010 Nov 17;5(11):e14015. 39.         Chan A, Paskavitz J, Remington R, et al. Efficacy of a vitamin/nutriceutical formulation for early-stage Alzheimer’s disease: a 1 year, open-label pilot study with an 16-month caregiver extension. Am J Alzheimers Dis Other Demen. 2008 Dec-2009 Jan;23(6):571-85. 40.         Remington R, Bechtel C, Larsen D, et al. A Phase II Randomized Clinical Trial of a Nutritional Formulation for Cognition and Mood in Alzheimer’s Disease. J Alzheimers Dis. 2015;45(2):395-405.41.         Remington R, Bechtel C, Larsen D, et al. Maintenance of Cognitive Performance and Mood for Individuals with Alzheimer’s Disease Following Consumption of a Nutraceutical Formulation: A One-Year, Open-Label Study. J Alzheimers Dis. 2016;51(4):991-5. 42.         Zanotta D, Puricelli S, Bonoldi G. Cognitive effects of a dietary supplement made from extract of Bacopa monnieri, astaxanthin, phosphatidylserine, and vitamin E in subjects with mild cognitive impairment: a noncomparative, exploratory clinical study. Neuropsychiatr Dis Treat. 2014 Feb 3;10:225-30.43.         Galasko DR, Peskind E, Clark CM, Quinn JF, Ringman JM, Jicha GA, Cotman C, Cottrell B, Montine TJ, Thomas RG, Aisen P; Alzheimer’s Disease Cooperative Study. Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. Arch Neurol. 2012 Jul;69(7):836-41.44.         Smith AD, Refsum H. Homocysteine, B Vitamins, and Cognitive Impairment. Annu Rev Nutr. 2016 Jul 17;36:211-39.45.         Douaud G, Refsum H, de Jager CA, Jacoby R, Nichols TE, Smith SM, Smith AD. Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9523-8.

  1. de Jager CA, Oulhaj A, Jacoby R, Refsum H, Smith AD. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: A randomized controlled trial. Int J Geriatr Psychiatry. 2012;27(6):592–600.

47.         Cheng D, Kong H, Pang W, Yang H, Lu H, Huang C, Jiang Y. B vitamin supplementation improves cognitive function in the middle aged and elderly with hyperhomocysteinemia. Nutr Neurosci. 2016 Dec;19(10):461-466.48.         Oulhaj A, Jernerén F, Refsum H, Smith AD, de Jager CA. Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment. J Alzheimers Dis. 2016;50(2):547-57.49.         Ma F, Wu T, Zhao J, Han F, Marseglia A, Liu H, Huang G. Effects of 6-Month Folic Acid Supplementation on Cognitive Function and Blood Biomarkers in Mild Cognitive Impairment: A Randomized Controlled Trial in China. J Gerontol A Biol Sci Med Sci. 2016 Oct;71(10):1376-83.50.         Chen H, Liu S, Ji L, Wu T, Ji Y, Zhou Y, Zheng M, Zhang M, Xu W, Huang G. Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial. Mediators Inflamm. 2016;2016:5912146.51.         Werder SF. Cobalamin deficiency, hyperhomocysteinemia, and dementia. Neuropsychiatr Dis Treat. 2010 May 6;6:159-95.52.         Eastley R, Wilcock GK, Bucks RS. Vitamin B12 deficiency in dementia and cognitive impairment: the effects of treatment on neuropsychological function. Int J Geriatr Psychiatry. 2000 Mar;15(3):226-33.53.         Kwok T, Lee J, Lam L, Woo J. Vitamin B(12) supplementation did not improve cognition but reduced delirium in demented patients with vitamin B(12) deficiency. Arch Gerontol Geriatr. 2008 May-Jun;46(3):273-82.54.         van Dyck CH, Lyness JM, Rohrbaugh RM, Siegal AP. Cognitive and psychiatric effects of vitamin B12 replacement in dementia with low serum B12 levels: a nursing home study. Int Psychogeriatr. 2009 Feb;21(1):138-47.55.         Chai GS, Jiang X, Ni ZF, Ma ZW, Xie AJ, Cheng XS, Wang Q, Wang JZ, Liu GP. Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine. J Neurochem. 2013 Feb;124(3):388-96.56.         Sun J, Wen S, Zhou J, Ding S. Association between malnutrition and hyperhomocysteine in Alzheimer’s disease patients and diet intervention of betaine. J Clin Lab Anal. 2016 Nov 7. doi: 10.1002/jcla.22090. [Epub ahead of print]57.         Wu S, Ding Y, Wu F, Li R, Hou J, Mao P. Omega-3 fatty acids intake and risks of dementia and Alzheimer’s disease: a meta-analysis. Neurosci Biobehav Rev. 2015 Jan;48:1-9.58.         Ammann EM, Pottala JV, Robinson JG, Espeland MA, Harris WS. Erythrocyte omega-3 fatty acids are inversely associated with incident dementia: Secondary analyses of longitudinal data from the Women’s Health Initiative Memory Study (WHIMS). Prostaglandins Leukot Essent Fatty Acids. 2017 Jun;121:68-75.59.         Pottala JV, Yaffe K, Robinson JG, Espeland MA, Wallace R, Harris WS. Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study. Neurology. 2014 Feb 4;82(5):435-42.60.         Fraga VG, Carvalho MDG, Caramelli P, de Sousa LP, Gomes KB. Resolution of inflammation, n-3 fatty acid supplementation and Alzheimer disease: A narrative review. J Neuroimmunol. 2017 Sep 15;310:111-119.61.         Freund Levi Y, Vedin I, Cederholm T, Basun H, Faxén Irving G, Eriksdotter M, Hjorth E, Schultzberg M, Vessby B, Wahlund LO, Salem N Jr, Palmblad J. Transfer of omega-3 fatty acids across the blood-brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer’s disease: the OmegAD study. J Intern Med. 2014 Apr;275(4):428-36.62.         Eriksdotter M, Vedin I, Falahati F, Freund-Levi Y, Hjorth E, Faxen-Irving G, Wahlund LO, Schultzberg M, Basun H, Cederholm T, Palmblad J. Plasma Fatty Acid Profiles in Relation to Cognition and Gender in Alzheimer’s Disease Patients During Oral Omega-3 Fatty Acid Supplementation: The OmegAD Study. J Alzheimers Dis. 2015;48(3):805-12.63.         Vedin I, Cederholm T, Freund-Levi Y, Basun H, Garlind A, Irving GF, Eriksdotter-Jönhagen M, Wahlund LO, Dahlman I, Palmblad J. Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study. PLoS One. 2012;7(4):e35425.64.         Nock TG, Chouinard-Watkins R, Plourde M. Carriers of an apolipoprotein E epsilon 4 allele are more vulnerable to a dietary deficiency in omega-3 fatty acids and cognitive decline. Biochim Biophys Acta. 2017 Oct;1862(10 Pt A):1068-1078.65.         Holmquist L, Stuchbury G, Berbaum K, Muscat S, Young S, Hager K, Engel J, Münch G. Lipoic acid as a novel treatment for Alzheimer’s disease and related dementias. Pharmacol Ther. 2007 Jan;113(1):154-64.

  1. Fava A, Pirritano D, Plastino M, et al. The effect of lipoic acid therapy on cognitive functioning in patients with Alzheimer’s Disease. J Neurodegener Dis. 2013; 2013:454253.

67.         Shinto L, Quinn J, Montine T, et al. A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer’s disease. J Alzheimers Dis. 2014;38(1):111 20.68.         Pepeu G, Pepeu IM, Amaducci L. A review of phosphatidylserine pharmacological and clinical effects. Is phosphatidylserine a drug for the ageing brain?Pharmacol Res. 1996 Feb;33(2):73-80.69.         Richter Y, Herzog Y, Lifshitz Y, Hayun R, Zchut S. The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study. Clin Interv Aging. 2013;8:557-63.70.         Richter Y, Herzog Y, Cohen T, Steinhart Y. The effect of phosphatidylserine-containing omega-3 fatty acids on memory abilities in subjects with subjective memory complaints: a pilot study. Clin Interv Aging. 2010 Nov 2;5:313-6.71.         Moré MI, Freitas U, Rutenberg D. Positive effects of soy lecithin-derived phosphatidylserine plus phosphatidic acid on memory, cognition, daily functioning, and mood in elderly patients with Alzheimer’s disease and dementia. Adv Ther. 2014 Dec;31(12):1247-672.         Kato-Kataoka A, Sakai M, Ebina R, Nonaka C, Asano T, Miyamori T. Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. J Clin Biochem Nutr. 2010 Nov;47(3):246-5573.         Skvarc DR, Dean OM, Byrne LK, Gray L, Lane S, Lewis M, Fernandes BS, Berk M, Marriott A. The effect of N-acetylcysteine (NAC) on human cognition – A systematic review. Neurosci Biobehav Rev. 2017 Jul;78:44-56.

  1. Pocernich CB, Butterfield DA. Elevation of glutathione as a therapeutic strategy in Alzheimer disease. Biochim Biophys Acta. 2012 May;1822(5):625-30.

75.         Adair JC, Knoefel JE, Morgan N. Controlled trial of N-acetylcysteine for patients with probable Alzheimer’s disease. Neurology. 2001 Oct 23;57(8):1515-7.76.         Chan A, Remington R, Kotyla E, Lepore A, Zemianek J, Shea TB. A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. J Nutr Health Aging. 2010 Mar;14(3):224-30.77.         Remington R, Chan A, Paskavitz J, Shea TB. Efficacy of a vitamin/nutraceutical formulation for moderate-stage to later-stage Alzheimer’s disease: a placebo-controlled pilot study. Am J Alzheimers Dis Other Demen. 2009 Feb-Mar;24(1):27-33.

HEART RESEARCH UPDATE Simon Martin

  1. DiNicolantonio JJ et al. Targeting aspirin resistance with nutraceuticals: A possible strategy for reducing cardiovascular morbidity and mortality. Open Heart 2017, 4(2).
  2. Hydrogen Peroxide Watery Fuel for Change in Vascular Biology,

Frank M. Faraci. Arteriosclerosis, Thrombosis, and Vascular Biology 2006;26:1931-1933. https://doi.org/10.1161/01.ATV.0000238355.56172.b3.

  1. Zagli G et al. Hydrogen sulfide inhibits human platelet aggregation. European Journal of Pharmacology 2007, 559(1): 65-68. https://doi.org/10.1016/j.ejphar.2006.12.011.
    4. Larson MK at al. Omega-3 fatty acids modulate collagen signaling in human platelets. Prostaglandins Leukot Essent Fatty Acids 2011;84:93–8.doi:10.1016/j.plefa.2010.11.004.

Devries S et al. A deficiency of nutrition education and practice in cardiology. Am J Med 2017, 127: 9. http://www.amjmed.com/article/S0002-9343(17)30527-2/fulltext.

Maryam Sharifi‐Sanjani, Nicholas M. Oyster, Elisia D. Tichy, Kenneth C. Bedi, Ofer Harel, Kenneth B. Margulies, Foteini Mourkioti. Cardiomyocyte‐Specific Telomere Shortening is a Distinct Signature of Heart Failure in Humans. Journal of the American Heart Association, September 2017 DOI: 10.1161/JAHA.116.005086.

FRONTIERS: Simon Mills
1. Bennett HD et al. Health coaching for patients with chronic illness. Fam Pract Manag 210, 17, 5, 24-9.
2. www.dh.gov.uk/selfcare.

RESEARCH UPDATE

Paul Gellert, Petra von Berenberg, Monika Oedekoven, Maria Klemt, Christine Zwillich, Stefan Hörter, Adelheid Kuhlmey, Dagmar Dräger. Centenarians Differ in Their Comorbidity Trends During The 6 Years Before Death Compared to Individuals Who Died in Their 80s or 90s. The Journals of Gerontology: Series A, 2017; DOI: 10.1093/gerona/glx136.

Ashley A. Ross, Andrew C. Doxey, Josh D. Neufeld. The Skin Microbiome of Cohabiting Couples. mSystems, July 2017 DOI: 10.1128/mSystems.00043-17 .

Claire T. McEvoy, Heidi Guyer, Kenneth M. Langa, Kristine Yaffe. Neuroprotective Diets Are Associated with Better Cognitive Function: The Health and Retirement Study. Journal of the American Geriatrics Society, 2017; DOI: 10.1111/jgs.14922.

Eric L. Garland, Anne K. Baker, Paula Larsen, Michael R. Riquino, Sarah E. Priddy, Elizabeth Thomas, Adam W. Hanley, Patricia Galbraith, Nathan Wanner, Yoshio Nakamura. Randomized Controlled Trial of Brief Mindfulness Training and Hypnotic Suggestion for Acute Pain Relief in the Hospital Setting. Journal of General Internal Medicine, 2017; DOI: 10.1007/s11606-017-4116-9.

Ather Ali, Theresa R Weiss, Douglas McKee, Alisa Scherban, Sumiya Khan, Maxine R Fields, Damian Apollo, Wajahat Z Mehal. Efficacy of individualised diets in patients with irritable bowel syndrome: a randomised controlled trial. BMJ Open Gastroenterology, 2017; 4 (1): e000164 DOI: 10.1136/bmjgast-2017-000164

Ling Wu, Paul Velander, Dongmin Liu, Bin Xu. Olive component oleuropein promotes β-cell insulin secretion and protects β-cells from amylin amyloid induced cytotoxicity. Biochemistry, 2017; DOI: 10.1021/acs.biochem.7b00199.

M F Hjorth, H M Roager, T M Larsen, S K Poulsen, T R Licht, M I Bahl, Y Zohar, A Astrup.

Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention. International Journal of Obesity, 2017; DOI: 10.1038/ijo.2017.220.

 

In Focus - Lyme Disease 2017
[1] Sapi E, Kaur N, Anyanwu S, Luecke DF, Datar A, Patel S, Rossi M, Stricker RB (2011) Evaluation of in-vitro antibiotic susceptibility of different morphological forms of Borrelia burgdorferi.  Infect Drug Resist 4:97-113

 

 

[1] Kenedy MR, Lenhart TR, Akins DR (2012) The role of Borrelia burgdorferi Outer Surface Proteins.  FEMS Immunol Med Microbiol 66:1-19

 

 

[1] Zhang J-R, Norris SJ (1998) Kinetics and in vivo induction of genetic variation of vlsE in Borrelia burgdorferi.  Infection and Immunity 66:3689-3697

 

 

[1] Embers ME, Ramamoorthy R, Philipp MT (2004) Survival strategies of Borrelia burgdorferi, the etiologic agent of Lyme disease.  Microbes and Infection 6:312-318

 

 

[1] Kuehn BM (2013) CDC estimates 300000 US cases of Lyme disease annually.  JAMA 310: 1110

 

 

[1] Lindgren E, Jaenson T and World Health Organization (2006) Lyme borreliosis in Europe: influences and climate change, epidemiology, ecology and adaptation measures. World Health Organization Regional Office for Europe

 

 

[1] Van den Wijngaard CC, Hofhuls A, Simoes M, Rood E, van Pelt W, Zeller H, Van Bortel W (2017) Surveillance perspective on Lyme borreliosis across the European Union and European Economic Area.  Euro Surveill 22 pii=30569

 

 

[1] Dubrey SW, Bhatia A, Woodham S, Rakowicz W (2013) Lyme disease in the United Kingdom.  Postgrad Med J 90:33-42

 

 

[1] Semenza JC, Menne B (2009) Climate change and infectious diseases in Europe. Lancet 9:365-375.

 

 

[1]Semenza JC, Menne B (2009) Climate change and infectious diseases in Europe. Lancet 9:365-375.

 

 

[1] Shaw SE, Day MJ, Birtles RJ, Breitschwerdt EB (2001) Tick-borne infectious diseases of dogs.  Trends in parasitology 17:74-80

 

 

[1] Harvey WT, Salvato P (2003) ‘Lyme disease’: ancient engine of an unrecognized borreliosis pandemic?  Medical Hypotheses 60:742-759

 

 

[1] Munro H, Mavin S, Duffy K, Evans R, Jarvis LM (2015) Seroprevalence of lyme borreliosis in Scottish blood donors.  Transfusion Medicine 25:284-286

 

 

[1] Zambrano MC, Beklemisheva AA, Bryksin AV, Newman SA, Cabello FC (2004) Borrelia burgdorferi binds to, invades and colonizes Native Type I Collagen Lattices.  Infection and Immunity 72:3138-3146

 

 

[1] Muller KE (2012) Damage of collagen and elastin fibres by Borrelia burgdorferi—known and new clinical and histopathological aspects.  The Open Neurology Journal 6(Suppl 1-M11):179-186

 

 

[1] Zambrano MC, Beklemisheva AA, Bryksin AV, Newman SA, Cabello FC (2004) Borrelia burgdorferi binds to, invades and colonizes Native Type I Collagen Lattices.  Infection and Immunity 72:3138-3146

 

 

[1] Tilly K, Rosa PA, Stewart PE (2008) Biology of infection with Borrelia burgdorferiInfect Dis Clin North Am 22:217-234

 

 

[1] Envita medical Centre (2017) Symptoms of Lyme Disease—the Great Imitator. Available at: https://www.envita.com  [Accessed 6th September 2017][1] Ingram C (2015) Lyme Disease Mimics a Vast Number of Other Diseases.   Available at: https://cassingram.com   [Accessed 7th September 2017][1] Gülçin I, Oktay M, Kireçci E, Küfrevioğlu I (2003) Screening of antioxidant and antimicrobial activities of anise (Pimpinella anisum L.) seed extracts.  Food Chemistry 83:371-382

 

 

[1] Francis G, Karem Z, Makkar HP, Becker K (2002) The biological action of saponins in animal systems: a review.  Br J Nutr 88:587-605.

 

 

[1] Kim B-Y, Cui Z-G, Lee S-R, Kim S-J, Kang H-K, Lee Y-K, Park D-B (2009) Effects of Asparagus officinalis extracts on cell toxicity and ethanol metabolism.  Journal of Food Science 74:H204-208

 

 

[1] Arthur S (2007) The effectiveness of Samento, Cumanda, Burbur and Dr Lee Cowden’s Protocol in the treatment of chronic Lyme disease.  Townsend Letter for Doctors and Patients 285:101

 

 

[1] Tan KH, Seers CA, Dashper SG, Mitchell HL, Pyke JS, Meuric V, Slakeski N, Cheal SM, Chambers JL, McConville MJ, Reynolds EC (2014) Porphyromonas gingivalis and Treponema denticola exhibit metabolic symbioses. PLoS Pathog 10(3): e1003955

 

 

[1] Brambilla E, Gagetti MG, Ionescu A, Campus G, Lingstrom P (2014) An in vitro and in vivo comparison of the effect of Stevia rebaudiana extracts on different caries-related variables: a randomized controlled trial pilot study.  Caries Res 48:19-23

 

 

[1] Theophilus PAS, Victoria MJ, Socarras KM, Filush KR, Gupta K, Luecke DF, Sapi E (2015) Effectiveness of Stevia rebaudiana whole leaf extract against the various morphological forms of Borrelia burgdorferi in vitroEuropean Journal of Microbiology and Immunology 5:268-280.

 

 

[1] Dryden M, Gaff H, McCombs G, Medlock J, Pietzsch M (2015) The dangers of tick-borne diseases: considerations for dental professionals. DH & T October:26-29

 

 

[1] Drenckhahn A, Spors B,Knierim E (2016) Acute isolated partial oculomotor nerve palsy due to Lyme neuroborreliosis in a 5 year old girl.  European Journal of Paediatric Neurology 20:977-979

 

 

[1] Lesser RL (1995) Ocular manifestations of Lyme disease.  The American Journal of Medicine 98(4): Supplement 1:60S-62S

 

 

[1] Guliani BP, Kuman S, Chawla N, Mehta A (2017) Neuroretinitis as presenting and the only presentation of Lyme disease: Diagnosis and management.  Indian Journal of Ophthalmology 65(3) 250-25

 

 

[1] Guliani BP, Kuman S, Chawla N, Mehta A (2017) Neuroretinitis as presenting and the only presentation of Lyme disease: Diagnosis and management.  Indian Journal of Ophthalmology 65(3) 250-252

 

 

[1] Klig JE (2008) Ophthalmologic Complications of Systemic Disease.  Emerg Med Clin N. Am 26:217-231Klig

 

 

[1] Steere AC, Duray PH, Kauffmann JH, Wormser GP (1985) Unilateral Blindness Caused by Infection with the Lyme Disease Spirochete, Borrelia burgdorferiAnnals of Internal Medicine 103(3): 382-384

 

 

[1] World Health Organization (2017) Trachoma.  Available at:    http://www.who.int/gho/neglected_diseases/trachoma/en    [Accessed 6th September 2017][1] Envita Medical Centre (2017)  Bartonella, a chronic Lyme disease coinfection, is more causing chronic fatigue problems.   Available at: https://www.envita.com  [Accessed 6th September 2017][1] Klig JE (2008) Ophthalmologic Complications of Systemic Disease.  Emerg Med Clin N. Am 26:217-231

 

 

[1] Klig JE (2008) Ophthalmologic Complications of Systemic Disease.  Emerg Med Clin N. Am 26:217-231

 

 

[1] Denniston AK, Keane PA (2015) Letter: Paravascular Pathways in the Eye: Is there an ‘Ocular Glymphatic System’?   Invest Ophthalmol Vis Sci 56:3955-3956

 

 


 

Lyme Disease and linked conditions:

References

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  2. Stricker RB, Middelveen MJ (2015) Sexual transmission of Lyme disease: challenging the tickborne disease paradigm. Expert review of anti-infective therapy 13 (11):1303-1306.
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September 2017

NEWS

Baker H, DeAngelis B, Holland B, Gittens-Williams L, Barrett T Jr. Vitamin Profile of 563 Gravidas during Trimesters of Pregnancy. Journal of the American College of Nutrition 2002;21(1):33–7.

 NAD Deficiency, Congenital Malformations, and Niacin Supplementation

Hongjun Shi et al. N Engl J Med 2017; 377:544-552. August 10, 2017 DOI: 10.1056/NEJMoa1616361.

 Long-term clinical and immunological effects of probiotic and peanut oral immunotherapy after treatment cessation: 4-year follow-up of a randomised, double-blind, placebo-controlled trial

Kuang-Chih Hsiao et al. The Lancet, Child and Adolescent Health, 15 August 2017.

DOI: http://dx.doi.org/10.1016/S2352-4642(17)30041-X

 Luisa Cimmino et al. Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression. Cell, 2017; DOI: 10.1016/j.cell.2017.07.032.

 BEN BROWN

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3.      Holtzman DM, Morris JC, Goate AM. Alzheimer’s disease: the challenge of the second century. Sci Transl Med. 2011 Apr 6;3(77):77sr1.

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12.  Jiang C, Li G, Huang P, Liu Z, Zhao B. The Gut Microbiota and Alzheimer’s Disease. J Alzheimers Dis. 2017;58(1):1-15.

13.  Zhao Y, Jaber V, Lukiw WJ. Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer’s Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus. Front Cell Infect Microbiol. 2017 Jul 11;7:318.

14.  Bonfili L, Cecarini V, Berardi S, et al. Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels. Sci Rep. 2017 May 25;7(1):2426.

15.  Akbari E, Asemi Z, Daneshvar Kakhaki R, Bahmani F, Kouchaki E, Tamtaji OR, Hamidi GA and Salami M (2016) Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer’s Disease: A Randomized, Double-Blind and Controlled Trial. Front. Aging Neurosci. 8:256. doi: 10.3389/fnagi.2016.00256

16.  Tuppo EE, Arias HR. The role of inflammation in Alzheimer’s disease. Int J Biochem Cell Biol. 2005 Feb;37(2):289-305.

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19.  Kesse-Guyot E, Assmann KE, Andreeva VA, et al. Long-term association between  the dietary inflammatory index and cognitive functioning: findings from the SU.VI.MAX study. Eur J Nutr. 2017 Jun;56(4):1647-1655.

20.  Hayden KM, Beavers DP, Steck SE, et al. The association between an inflammatory diet and global cognitive function and incident dementia in older women: The Women’s Health Initiative Memory Study. Alzheimers Dement. 2017 May 19. pii: S1552-5260(17)30185-1

21.  Gardener SL, Rainey-Smith SR, Martins RN. Diet and Inflammation in Alzheimer’s Disease and Related Chronic Diseases: A Review. J Alzheimers Dis. 2016;50(2):301-34.

22.  Esposito K, Marfella R, Ciotola M, Di Palo C, Giugliano F, Giugliano G, D’Armiento M, D’Andrea F, Giugliano D. Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA. 2004 Sep 22;292(12):1440-6.

23.  Singh B, Parsaik AK, Mielke MM, Erwin PJ, Knopman DS, Petersen RC, Roberts RO. Association of mediterranean diet with mild cognitive impairment and Alzheimer’s  disease: a systematic review and meta-analysis. J Alzheimers Dis. 2014;39(2):271-82.

24.  Valls-Pedret C, et al. Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial. JAMA Intern Med. 2015 Jul;175(7):1094-103

25.  Gandhi S, Abramov AY. Mechanism of oxidative stress in neurodegeneration. Oxid Med Cell Longev. 2012;2012:428010

26.  Zhao Y, Zhao B. Oxidative stress and the pathogenesis of Alzheimer’s disease. Oxid Med Cell Longev. 2013;2013:316523. 

27.  Praticò D. Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal. Trends Pharmacol Sci. 2008 Dec;29(12):609-15.

28.  Thapa A, Carroll NJ. Dietary Modulation of Oxidative Stress in Alzheimer’s Disease. Int J Mol Sci. 2017 Jul 21;18(7).

29.  Monacelli F, Acquarone E, Giannotti C, Borghi R, Nencioni A. Vitamin C, Aging  and Alzheimer’s Disease. Nutrients. 2017 Jun 27;9(7).

30.  Cervantes B, Ulatowski LM. Vitamin E and Alzheimer’s Disease-Is It Time for Personalised Medicine? Antioxidants (Basel). 2017 Jun 24;6(3).

31.  Dominiak A, Wilkaniec A, Wroczyński P, Adamczyk A. Selenium in the Therapy of  Neurological Diseases. Where is it Going? Curr Neuropharmacol. 2016;14(3):282-99.

32.  Thapa A, Carroll NJ. Dietary Modulation of Oxidative Stress in Alzheimer’s Disease. Int J Mol Sci. 2017 Jul 21;18(7).

33.  Bayer-Carter JL, Green PS, Montine TJ, et al. Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment. Arch Neurol. 2011 Jun;68(6):743-52.

34.  Wilkins HM, Morris JK. New Therapeutics to Modulate Mitochondrial Function in  Neurodegenerative Disorders. Curr Pharm Des. 2017;23(5):731-752.

35.  Wilkins HM, Swerdlow RH. Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer’s Disease. Curr Top Med Chem. 2016;16(8):849-57.

36.  Murugaiyah V, Mattson MP. Neurohormetic phytochemicals: An evolutionary-bioenergetic perspective. Neurochem Int. 2015 Oct;89:271-80.

37.  Akbar M, Essa MM, Daradkeh G, Abdelmegeed MA, Choi Y, Mahmood L, Song BJ. Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress. Brain Res. 2016 Apr 15;1637:34-55.

38.  Nicolson GL. Mitochondrial dysfunction and chronic disease: treatment with natural supplements. Altern Ther Health Med. 2014 Winter;20 Suppl 1:18-25.

39.  Wilkins HM, Swerdlow RH. Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer’s Disease. Curr Top Med Chem. 2016;16(8):849-57.

40.  Montgomery SA, Thal LJ, Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment  of mild cognitive impairment and mild Alzheimer’s disease. Int Clin Psychopharmacol. 2003 Mar;18(2):61-71.

41.  Birkmayer JG. Coenzyme nicotinamide adenine dinucleotide: new therapeutic approach for improving dementia of the Alzheimer type. Ann Clin Lab Sci. 1996; 26:1–9

42.  Demarin V, Podobnik SS, Storga-Tomic D, Kay G. Treatment of Alzheimer’s disease with stabilized oral nicotinamide adenine dinucleotide: a randomized, double-blind study. Drugs Exp Clin Res. 2004; 30:27–33.

43.  Bondy SC. Low levels of aluminum can lead to behavioural and morphological changes associated with Alzheimer’s disease and age-related neurodegeneration. Neurotoxicology. 2016 Jan;52:222-9.

44.  Tyler CR, Allan AM. The Effects of Arsenic Exposure on Neurological and Cognitive Dysfunction in Human and Rodent Studies: A Review. Curr Environ Health  Rep. 2014 Mar 21;1:132-147.

45.  Wang B, Du Y. Cadmium and its neurotoxic effects. Oxid Med Cell Longev. 2013;2013:898034.

46.  Bakulski KM, Rozek LS, Dolinoy DC, Paulson HL, Hu H. Alzheimer’s disease and environmental exposure to lead: the epidemiologic evidence and potential role of  epigenetics. Curr Alzheimer Res. 2012 Jun;9(5):563-73.

47.  Mutter J, Curth A, Naumann J, Deth R, Walach H. Does inorganic mercury play a  role in Alzheimer’s disease? A systematic review and an integrated molecular mechanism. J Alzheimers Dis. 2010;22(2):357-74.

48.  Yan D, Zhang Y, Liu L, Yan H. Pesticide exposure and risk of Alzheimer’s disease: a systematic review and meta-analysis. Sci Rep. 2016 Sep 1;6:32222.

49.  Wu YC, Lin YC, Yu HL, et al. Association between air pollutants and dementia risk in the elderly. Alzheimers Dement (Amst). 2015 May 14;1(2):220-8.

50.  Genuis SJ. Toxic causes of mental illness are overlooked. Neurotoxicology. 2008 Nov;29(6):1147-9

51.  Genuis SJ. Elimination of persistent toxicants from the human body. Hum Exp Toxicol. 2011 Jan;30(1):3-18.

52.  Helzner E.P, Luchsinger JA, Scarmeas N, et al. Contribution of vascular risk factors to the progression in Alzheimer disease. Arch Neurol. 2009;66:343–348.

53.  Santos CY, Snyder PJ, Wu WC, Zhang M, Echeverria A, Alber J. Pathophysiologic  relationship between Alzheimer’s disease, cerebrovascular disease, and cardiovascular risk: A review and synthesis. Alzheimers Dement (Amst). 2017 Feb 9;7:69-87.

54.  Davey DA. Alzheimer’s disease and vascular dementia: one potentially preventable and modifiable disease? Part II: Management, prevention and future perspective. Neurodegener Dis Manag. 2014;4(3):261-70.

55.  Pardeshi R, Bolshette N, Gadhave K, et al. Insulin signaling: An opportunistic target to minify the risk of Alzheimer’s disease. Psychoneuroendocrinology. 2017 Sep;83:159-171.

56.  Talbot K, Wang HY, Kazi H, et al. Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest. 2012 Apr;122(4):1316-38.

57.  Huang CC, Chung CM, Leu HB, et al. Diabetes mellitus and the risk of Alzheimer’s disease: a nationwide population-based study. PLoS One. 2014 Jan 29;9(1):e87095.

58.  Berti V, Murray J, Davies M,et al. Nutrient patterns and brain biomarkers of Alzheimer’s disease in cognitively normal individuals. J  Nutr Health Aging. 2015 Apr;19(4):413-23.

59.  Pase MP, Himali JJ, Jacques PF, DeCarli C, Satizabal CL, Aparicio H, Vasan RS, Beiser AS, Seshadri S. Sugary beverage intake and preclinical Alzheimer’s disease in the community. Alzheimers Dement. 2017 Mar 6. pii: S1552-5260(17)30050-X.

60.  Roberts RO, Roberts LA, Geda YE, et al. Relative intake of macronutrients impacts risk of mild cognitive impairment or dementia. J Alzheimers Dis. 2012;32(2):329-39.

61.  Stefanidis A, Watt MJ. Does too much sugar make for lost memories? J Physiol. 2012 Aug 15;590(16):3633-4.

62.  Feinman RD, Pogozelski WK, Astrup A, et al. Dietary carbohydrate restriction as the first approach in diabetes management: Critical review and evidence base. Nutrition. 2015 Jan;31(1):1-13

63.  Szkudelski T, Szkudelska K. Resveratrol and diabetes: from animal to human studies. Biochim Biophys Acta. 2015 Jun;1852(6):1145-54.

64.  Turner RS, Thomas RG, Craft S, van Dyck CH, Mintzer J, Reynolds BA, Brewer JB, Rissman RA, Raman R, Aisen PS; Alzheimer’s Disease Cooperative Study. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology. 2015 Oct 20;85(16):1383-91.

65.  Moussa C, Hebron M, Huang X, et al. Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease. J Neuroinflammation. 2017 Jan 3;14(1):1.

66.  Köbe T, Witte AV, Schnelle A, et al. Impact of Resveratrol on Glucose Control, Hippocampal Structure and Connectivity, and Memory Performance in Patients with Mild Cognitive Impairment. Front Neurosci. 2017 Mar 7;11:105.

 PATRICK HOILFORD

SEVEN ESSENTIALS FOR 100% HEALTH

 1. See www.patrickholford.com/advice/chromium-the-evidence

 2. Guimaraes M etal.’Effect of chromium supplementation on the glucose homeostasis and anthropometry of type 2 diabetic patients: Double blind, randomized clinical trial.’ J Trace Elem Med Biol. 2016 Jul;36:65-72

3. Paiva AN et al., ‘Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study.‘J Trace Elem Med Biol. 2015 Oct;32:66-72 -/26302914

4. H. Hemila et al., ‘Vitamin C and Infections’ Nutrients. 2017 Mar 29;9(4).

5. T Spector, ‘Epigenetics of discordant monozygotic twins: implications for disease’ Genome Med. 2014; 6(7): 60

6. Harrison S et al, ‘Does milk intake promote prostate cancer initiation or progression via effects on insulin-like growth factors (IGFs)? A systematic review and meta-analysis.’ Cancer Causes Control. 2017 Jun;28(6):497-528.

7. Bao J et al, ‘Prediction of postprandial glycemia and insulinemia in lean, young, healthy adults: glycemic load compared with carbohydrate content alone.’Am J Clin Nutr. 2011 May;93(5):984-96

8. Bischoff-Ferrari H. ‘Optimal serum 25-hydroxyvitamin D levels for multiple health outcomes.’ Adv Exp Med Biol. 2014 ;810:500-25;  also Pludowski P et al., ‘Vitamin D supplementation guidelines.’ J Steroid Biochem 2017 Feb 12. pii: S0960-0760(17)30031-6.

9. Fan S et al, ‘BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.Br J Cancer. 2006 Feb 13;94(3):407-26/16434996

10. https://www.holfordirect.com/100-health-survey-patrick-holford.html

 AGEING

Andrew Kingston, Pia Wohland, Raphael Wittenberg, Louise Robinson, Carol Brayne, Fiona E Matthews, Carol Jagger, E Green, L Gao, R Barnes, A Arthur, C Baldwin, L E Barnes, C Brayne, A Comas-Herrera, T Dening, G Forster, S Harrison, P G Ince, C Jagger, F E Matthews, I G McKeith, B Parry, J Pickett, L Robinson, B C M Stephan, S Wharton, R Wittenberg, B Woods, R Weller. Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS). The Lancet, 2017; DOI: 10.1016/S0140-6736(17)31575-1.  

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.

Xu M, Tchkonia T, Ding H, Ogrodnik M, Lubbers ER, Pirtskhalava T, White TA, Johnson KO, Stout MB, Mezera V, Giorgadze N, Jensen MD, LeBrasseur NK, Kirkland JL. Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6301-10. doi: 10.1073/pnas.1515386112. Epub 2015 Nov 2.

 Natural products targeting STAT3 signaling pathways in cancer cells. Biodesign 2016, 4 (1), 004 (01), 1-17. Yena Jin, Younghwan Kim,  Yu-Jin Lee, Dong Cho Han, Byoung-Mog Kwon. http://www.bdjn.org/APP_PDF/BDJN004-01-01.pdf.  

 Lutein and Zeaxanthin Influence Brain Function in Older Adults: A Randomized Controlled Trial. Lindbergh CA, Renzi-Hammond LM, Hammond BR, Terry DP, Mewborn CM, Puente AN, Miller LS.  J Int Neuropsychol Soc. 2017 Jul 11:1-14. doi: 10.1017/S1355617717000534. [Epub ahead of print]

RESEARCH UPDATE

Robert Sonowal, Alyson Swimm, Anusmita Sahoo, Liping Luo, Yohei Matsunaga, Ziqi Wu, Jui A. Bhingarde, Elizabeth A. Ejzak, Ayush Ranawade, Hiroshi Qadota, Domonica N. Powell, Christopher T. Capaldo, Jonathan M. Flacker, Rhienallt M. Jones, Guy M. Benian, and Daniel Kalman. Indoles from commensal bacteria extend healthspan. PNAS, August 21, 2017 DOI: 10.1073/pnas.1706464114

Olga Theou, Joanna M. Blodgett, Judith Godin, Kenneth Rockwood. Association between sedentary time and mortality across levels of frailty. Canadian Medical Association Journal, 2017; 189 (33): E1056 DOI: 10.1503/cmaj.161034.

Austin T. Mudd, Kirsten Berding, Mei Wang, Sharon M. Donovan, Ryan N. Dilger. Serum cortisol mediates the relationship between fecal Ruminococcus and brain N-acetylaspartate in the young pig. Gut Microbes, 2017; 1 DOI: 10.1080/19490976.2017.1353849

 Pinaki Panigrahi, Sailajanandan Parida, Nimai C. Nanda, Radhanath Satpathy, Lingaraj Pradhan, Dinesh S. Chandel, Lorena Baccaglini, Arjit Mohapatra, Subhranshu S. Mohapatra, Pravas R. Misra, Rama Chaudhry, Hegang H. Chen, Judith A. Johnson, J. Glenn Morris, Nigel Paneth, Ira H. Gewolb. A randomized synbiotic trial to prevent sepsis among infants in rural India. Nature, 2017; DOI: 10.1038/nature23480

 Claire E Berryman, Jennifer A Fleming, Penny M Kris-Etherton. Inclusion of Almonds in a Cholesterol-Lowering Diet Improves Plasma HDL Subspecies and Cholesterol Efflux to Serum in Normal-Weight Individuals with Elevated LDL Cholesterol. The Journal of Nutrition, 2017; 147 (8): 1517 DOI: 10.3945/jn.116.245126

 

 

 

 

 

In Focus - Gut Health

HTTPS://WWW.NCBI.NLM.NIH.GOV/PUBMED/12690629 

HTTPS://WWW.NCBI.NLM.NIH.GOV/PUBMED/22109896

Chan Y., Chang T., Chan Ch., Yeh YC., Chen CW, Shieh B, Li C. Immunomodulatory effects of Agaricus blazei Murrill in Balb/cByJ mice. J microbiol immunological infect. 2007 Jun;40(3):201-8.

Chiu HF, Fu HY, Lu YY, Han YC, Shen YC, Venkatakrishnan K, Golovinskaia O, Wang CK (2017). Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers. Pharm Biol 55, 1041-1046.

Dai Yu-C, Yang Z-L, Cui B-K, et al (2009). Species diversity and utilization of medicinal mushrooms and fungi in China (review). Int J Med Mush: 11: 287?302.
Haynes, A. (2012). A Functional Medicine Approach to Auto-Imune Conditions: A Case History Led Seminar. Nutri-Link Ltd Clincal Education

Hetland G. Medicinal Effects on Tumor & Inflammation through Its Modulation of Immunity & Inflammtion. Adv. in Pharm. Scien. 2011

Liu C, Dunkin D, Lai J, Song Y, Ceballos C, Benkov K, Li XM. Anti-inflammatory Effects of Gaderma lucidum Triterpenoid in Human Crohn’s Disease Associated with Downregulation of NF

Signaling. Inflamm Bowel Dis. 2015 Aug;21(8):1918-25. doi: 10.1097/MIB.0000000000000439.

Kolotushkina EV, Moldavan MG, Voronin KY, Skibo GG. The influence of Hericium erinaceus extract on myelination process in vitro. Fiziol.Zh. 2003; vol.49(1): 38-45
Mizuno M1, Nishitani Y. Immunomodulating compounds in Basiiomycetes. J Clin Biochem Nutr. 2013 May;52(3):202-7

Takenaka MC, Robson S, Quintana FJ. Regulation of the T Cell Response by CD39. Trends Imunol. 2016 May 25. pii: S1471-4906(16)30031-X. doi: 10.1016/j.it.2016.04.009. [Epub ahead of print

The impact of antibiotics

[1] Voigt RM et al (2014) Circadian Disorganization Alters Intestinal Microbiota. PLoS ONE 9(5):e97500. Doi:10.1371/journal.pone.0097500

 

[1] Konturek PC et al (2011) Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options. J Physiol Pharmacol 62(6):591-599

 

[1] Conlon MA & Bird AR (2015) The Impact of Diet and Lifestyle on Gut Microbiota and Human Health. Nutrients 7(1):17-44

 

[1] Macpherson AJ & Harris NL (2004) Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol 4:478-485

 

[1] MacDonald TT & Monteleone G (2005) Immunity, Inflammation, and Allergy in the Gut. Science 307:1920-1925

 

[1] Round JL & Mazmanian SK (2009) The gut microbiome shapes intestinal immune responses during health and disease. Nat Rev Immunol 9(5):313-323

 

[1] Del Chierico F et al (2015) Phylogenetic and Metabolic Tracking of Gut Microbiota during Perinatal Development. PLoS ONE; DOI:10.1371/journal.pone.0137347

 

[1] Backhed F et al (2015) Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 17:690-703

 

[1] Tannock GW et al (2013) Comparison of the compositions of the stool microbiotas of infants fed goat milk formula, cow milk-based formula, or breast milk. Appl Environ Microbiol 79:3040-8
[1] Hussey S et al (2012) Parenteral antibiotics reduce bifidobacteria colonization and diversity in neonates. Int J Microbiol doi: 10/1155/2011/130574
[1] Chow J et al (2010) Host-Bacterial Symbiosis in Health and Disease. Adv Immunol 107:243-274

 

[1] Petersen C & Round JL (2014) Defining dysbiosis and its influence on host immunity and disease. Cell Microbiol 16(7):1024-1033

 

[1] Clemente JC et al (2012) The Impact of the Gut Microbiota on Human Health: An Integrative View. Cell 148: 1258-1270

 

[1] Vangay P et al (2015) Antibiotics, Pediatric Dysbiosis, and Disease. Cell Host Microbe 17(5):553-564

 

[1] Dethlefsen L & Relman DA (2011) Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. PNAS 108(1):4554-4561
[1] Clemente JC et al (2012) The Impact of the Gut Microbiota on Human Health: An Integrative View. Cell 148: 1258-1270
[1] Francino MP (2016). Antibiotics and the Human Gut Microbiome: Dysbioses and Accumulation of Resistances. Front Microbiol 6:1543

 

[1] Reid G (2006) Probiotics to prevent the need for, and augment the use of, antibiotics. Can J Infect Dis Med Microbiol 17(5):291-295

 

[1] Plummer SF et al (2005) Effects of probiotics on the composition of the intestinal microbiota following antibiotic therapy. Int J Antimicrob Agents 26:69-74

 

[1] Madden JAJ et al (2005) Effect of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: A double-blind placebo-controlled pilot study. Int Immunopharmacol 5:1091-1097

 

[1] Petersen C & Round JL (2014) Defining dysbiosis and its influence on host immunity and disease. Cell Microbiol 16(7):1024-1033

 

[1] Petersen C & Round JL (2014) Defining dysbiosis and its influence on host immunity and disease. Cell Microbiol 16(7):1024-1033
[1] Conlon MA & Bird AR (2015) The Impact of Diet and Lifestyle on Gut Microbiota and Human Health. Nutrients 7(1):17-44

 

August 2017

NEWS

Am J Clin Nutr. 2017 Jul 5. pii: ajcn138693. doi: 10.3945/ajcn.116.138693. [Epub ahead of print]. Daily supplementation with 15 μg vitamin D2 compared with vitamin D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: a 12-wk randomized, placebo-controlled food-fortification trial.

Tripkovic L1, Wilson LR2, Hart K2, Johnsen S3, de Lusignan S4, Smith CP5, Bucca G5, Penson S6, Chope G6, Elliott R2, Hyppönen E7, Berry JL8, Lanham-New SA2.

 

Frontiers in Aging Neuroscience 2017; 9 : 168. Neuroprotective and Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants. Muhammad Ayaz, Abdul Sadiq, Muhammad Junaid, Farhat Ullah, Fazal Subhan, Jawad Ahmed. PMID: 28611658.

Osada H, Okamoto T, Kawashima H, Toda, E, Miyake S, Nagai N, et al. (2017) Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina. PLoS ONE 12(6): e0178627. https://doi.org/10.1371/journal.pone.0178627.

Kirsten E. Bell, Tim Snijders, Michael Zulyniak, Dinesh Kumbhare, Gianni Parise, Adrian Chabowski, Stuart M. Phillips. A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial. PLOSONE, 2017; 12 (7): e0181387 DOI: 10.1371/journal.pone.0181387.

Timothy J. Wilt, Karen M. Jones, Michael J. Barry, Gerald L. Andriole, Daniel Culkin, Thomas Wheeler, William J. Aronson, Michael K. Brawer. Follow-up of Prostatectomy versus Observation for Early Prostate Cancer. New England Journal of Medicine, 2017; 377 (2): 132 DOI: 10.1056/NEJMoa1615869.

Meghan B. Azad, Ahmed M. Abou-Setta, Bhupendrasinh F. Chauhan, Rasheda Rabbani, Justin Lys, Leslie Copstein, Amrinder Mann, Maya M. Jeyaraman, Ashleigh E. Reid, Michelle Fiander, Dylan S. MacKay, Jon McGavock, Brandy Wicklow, Ryan Zarychanski. Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. Canadian Medical Association Journal, 2017; 189 (28): E929 DOI: 10.1503/cmaj.161390

NEWS EXTRA
Rebecca Spain, Katherine Powers, Charles Murchison, Elizabeth Heriza, Kimberly Winges, Vijayshree Yadav, Michelle Cameron, Ed Kim, Fay Horak, Jack Simon, Dennis Bourdette. Lipoic acid in secondary progressive MS. Neurology – Neuroimmunology Neuroinflammation, 2017; 4 (5): e374 DOI: 10.1212/NXI.0000000000000374

BEN BROWN endotoxin

  1. Laveti D, Kumar M, Hemalatha R, Sistla R, Naidu VG, Talla V, Verma V, Kaur N, Nagpal R. Anti-inflammatory treatments for chronic diseases: a review. Inflamm Allergy Drug Targets. 2013 Oct;12(5):349-61.
  2. Saad MJ, Santos A, Prada PO. Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance. Physiology (Bethesda). 2016 Jul;31(4):283-93.
  3. Minihane AM, Vinoy S, Russell WR, Baka A, Roche HM, Tuohy KM, Teeling JL, Blaak EE, Fenech M, Vauzour D, McArdle HJ, Kremer BH, Sterkman L, Vafeiadou K, Benedetti MM, Williams CM, Calder PC. Low-grade inflammation, diet composition and health: current research evidence and its translation. Br J Nutr. 2015 Oct 14;114(7):999-1012.
  4. Calder PC, Albers R, Antoine JM, et al. Inflammatory disease processes and interactions with nutrition. Br J Nutr. 2009 May;101 Suppl 1:S1-45.
  5. Bischoff SC, Barbara G, Buurman W, Ockhuizen T, Schulzke JD, Serino M, Tilg H, Watson A, Wells JM. Intestinal permeability–a new target for disease prevention and therapy. BMC Gastroenterol. 2014 Nov 18;14:189.
  6. Erridge C, Duncan SH, Bereswill S, Heimesaat MM. The induction of colitis and ileitis in mice is associated with marked increases in intestinal concentrations of stimulants of TLRs 2, 4, and 5. PLoS ONE 2010;5:e9125.
  7. Erridge C. The capacity of foodstuffs to induce innate immune activation of human monocytes in vitro is dependent on food content of stimulants of Toll-like receptors 2 and 4. Br J Nutr. 2011 Jan;105(1):15-23.
  8. Erridge C. Stimulants of Toll-like receptor (TLR)-2 and TLR-4 are abundant in certain minimally-processed vegetables. Food Chem Toxicol. 2011 Jun;49(6):1464-7.
  9. Erridge C. Diet, commensals and the intestine as sources of pathogen-associated molecular patterns in atherosclerosis, type 2 diabetes and non-alcoholic fatty liver disease. Atherosclerosis. 2011 May;216(1):1-6.
  10. Herieka M, Faraj TA, Erridge C. Reduced dietary intake of pro-inflammatory Toll-like receptor stimulants favourably modifies markers of cardiometabolic risk in healthy men. Nutr Metab Cardiovasc Dis. 2016 Mar;26(3):194-200.

Endotoxin and atherosclerosis (Simon Martin)

  1. Clett Erridge, Teresa Attina, Corinne M Spickett and David J Webb. A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation. Am J Clin Nutr 2007, 86 (5):1286-92. Online at http://ajcn.nutrition.org/content/86/5/1286.long.
    2. Swaroop Pendyala, Jeanne M. Walker, and Peter R. Holt

A High-Fat Diet Is Associated With Endotoxemia That Originates From the Gut.

Gastroenterology. 2012 May; 142(5): 1100–1101.e2.

Published online 2012 Feb 8. doi:  10.1053/j.gastro.2012.01.034

Ice Man
M. Kox, L. T. van Eijk, J. Zwaag, J. van den Wildenberg, F. C. G. J. Sweep, J. G. van der Hoeven, P. Pickkers. Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans. Proceedings of the National Academy of Sciences, 2014; DOI: 10.1073/pnas.1322174111

SIMON MILLS – Cinnamon

  1. Dalby, A (2000). Dangerous Tastes: The Story of Spices.  British Library, London.
  2. Vincent, W (1800) The Periplus of the Erythrean Sea: Part the First. London
  3. He ZD, Qiao CF Han QB et al (2005). Authentication and quantitative analysis on the chemical profile of cassia bark (cortex cinnamomi) by high-pressure liquid chromatography. J Agric Food Chem vol 53, no 7, pp 2424-8
  4. EFSA (European Food Safety Authority) (2008) Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC): Question No EFSA-Q-2008-677. “Coumarin in flavourings and other food ingredients with flavouring properties”. The EFSA Journal, vol 793, pp 1-15
  5. Crawford P, Thai C, Obholz J, et al (2016) Assessment of the effect of lIfestyle intervention plus water-soluble cinnamon extract on lowering blood glucose in pre-diabetics, a randomized, double-blind, multicenter, placebo controlled trial: study protocol for a randomized controlled trial. vol 5, no 17,p 9
  6. Zhang Z, Ye F, Wiseman N, and Mitchell, C (1999). Shang Han Lun: On Cold Damage, Translation and Commentaries. Paradigm Publications
  7. Ravindran PN, Nirmal-Babu K, Shylaja M eds (2005) Cinnamon and Cassia: The Genus Cinnamomum. CRC Press
  8. Perry LM (1980) Medicinal plants of East and Southeast Asia: attributed properties and uses. MIT Press

EFA research

Aram Asatryan, Nicolas G. Bazan. Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection. Journal of Biological Chemistry, 2017; jbc.R117.783076 DOI: 10.1074/jbc.R117.783076

Daniel R. McDougle, Josephine E. Watson, Amr A. Abdeen, Reheman Adili, Megan P. Caputo, John E. Krapf, Rodney W. Johnson, Kristopher A. Kilian, Michael Holinstat, Aditi Das. Anti-inflammatory ω-3 endocannabinoid epoxides. Proceedings of the National Academy of Sciences, 2017; 201610325 DOI: 10.1073/pnas.1610325114

Abdo Alnabulsi et al. The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance, British Journal of Cancer (2017). DOI: 10.1038/bjc.2017.135

Jana Trebatická, et al. Emulsified omega-3 fatty-acids modulate the symptoms of depressive disorder in children and adolescents: a pilot study. Child and Adolescent Psychiatry and Mental Health201711:30. DOI: 10.1186/s13034-017-0167-2. Online at

https://capmh.biomedcentral.com/articles/10.1186/s13034-017-0167-2.

Benjamin J. Andreone, Brian Wai Chow, Aleksandra Tata, Baptiste Lacoste, Ayal Ben-Zvi, Kevin Bullock, Amy A. Deik, David D. Ginty, Clary B. Clish, Chenghua Gu. Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. Neuron, 2017; 94 (3): 581 DOI: 10.1016/j.neuron.2017.03.043

RESEARCH

Victoria A. Acosta-Rodríguez, Marleen H.M. de Groot, Filipa Rijo-Ferreira, Carla B. Green, Joseph S. Takahashi. Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System. Cell Metabolism, 2017; 26 (1): 267 DOI: 10.1016/j.cmet.2017.06.007

Chen-Song Zhang, Simon A. Hawley, Yue Zong, Mengqi Li, Zhichao Wang, Alexander Gray, Teng Ma, Jiwen Cui, Jin-Wei Feng, Mingjiang Zhu, Yu-Qing Wu, Terytty Yang Li, Zhiyun Ye, Shu-Yong Lin, Huiyong Yin, Hai-Long Piao, D. Grahame Hardie, Sheng-Cai Lin. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature, 2017; DOI: 10.1038/nature23275.

 

Jeffrey Lienert, Christopher Steven Marcum, John Finney, Felix Reed-Tsochas, Laura Koehly. Social influence on 5-year survival in a longitudinal chemotherapy ward co-presence network. Network Science, 2017; 1 DOI: 10.1017/nws.2017.16

Colter Mitchell, Sara McLanahan, Lisa Schneper, Irv Garfinkel, Jeanne Brooks-Gunn, Daniel Notterman. Father Loss and Child Telomere Length. Pediatrics, 2017; e20163245 DOI: 10.1542/peds.2016-3245.

Alexander L. Carlson, Kai Xia, M. Andrea Azcarate-Peril, Barbara D. Goldman, Mihye Ahn, Martin A. Styner, Amanda L. Thompson, Xiujuan Geng, John H. Gilmore, Rebecca C. Knickmeyer. Infant Gut Microbiome Associated with Cognitive Development. Biological Psychiatry, 2017; DOI: 10.1016/j.biopsych.2017.06.021.

David C. Emery, Deborah K. Shoemark, Tom E. Batstone, Christy M. Waterfall, Jane A. Coghill, Tanya L. Cerajewska, Maria Davies, Nicola X. West, Shelley J. Allen. 16S rRNA Next Generation Sequencing Analysis Shows Bacteria in Alzheimer’s Post-Mortem Brain. Frontiers in Aging Neuroscience, 2017; 9 DOI: 10.3389/fnagi.2017.00195

July 2017

NEWS

Marc M Cohen, De Villiers Smit, Nick Andrianopoulos, Michael Ben-Meir, David McD Taylor, Shefton J Parker, Chalie C Xue, Peter A Cameron. Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non-inferiority trial. The Medical Journal of Australia, 2017; 206 (11): 494 DOI: 10.5694/mja16.00771

Annika S. Axelsson et al. Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes. Science Translational Medicine, 2017 DOI: 10.1126/scitranslmed.aah4477

Daniel G. Amen, William S. Harris, Parris M. Kidd, Somayeh Meysami, and Cyrus A. Raji. Quantitative Erythrocyte Omega-3 EPA Plus DHA Levels Are Related to Higher Regional Cerebral Blood Flow on Brain SPECT. Journal of Alzheimer’s Disease, May 2017 DOI: 10.3233/JAD-17028

Higher Antioxidant Activity, Total Flavonols, and Specific Quercetin Glucosides in Two Different Onion (Allium cepa L.) Varieties Grown under Organic Production: Results from a 6-Year Field Study. Feiyue Ren Kim Reilly, Joseph P. Kerry, Michael Gaffney, Mohammad Hossain, and Dilip K. Rai

  1. Agric. Food Chem., DOI: 10.1021/acs.jafc.7b01352.

Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association. Frank M. Sacks, Alice H. Lichtenstein, Jason H.Y. Wu, Lawrence J. Appel, Mark A. Creager, Penny M. Kris-Etherton, Michael Miller, Eric B. Rimm, Lawrence L. Rudel, Jennifer G. Robinson, Neil J. Stone, Linda V. Van Horn, On behalf of the American Heart Association. https://doi.org/10.1161/CIR.0000000000000510

Circulation. 2017; originally published June 15, 2017.

“Study Confirms: Trans Fats Policy Killed Millions”: http://articles.mercola.com/sites/articles/archive/2017/06/07/trans-fats-policy-killed-millions.aspx

BEN BROWN

1.Ruemmele FM. Role of Diet in Inflammatory Bowel Disease. Ann Nutr Metab. 2016;68 Suppl 1:33-41.

2.Vindigni SM, Zisman TL, Suskind DL, Damman CJ. The intestinal microbiome,  barrier function, and immune system in inflammatory bowel disease: a tripartite pathophysiological circuit with implications for new therapeutic directions. Therap Adv Gastroenterol. 2016 Jul;9(4):606-25

  1. Lee D, Albenberg L, Compher C, Baldassano R, Piccoli D, Lewis JD, Wu GD. Diet in the pathogenesis and treatment of inflammatory bowel diseases. Gastroenterology. 2015 May;148(6):1087-106.
  2. Monteiro CA, Moubarac JC, Cannon G, Ng SW, Popkin B. Ultra-processed products are becoming dominant in the global food system. Obes Rev. 2013 Nov;14 Suppl 2:21-8.
  3. Lerner A, Matthias T. Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease. Autoimmun Rev. 2015 Jun;14(6):479-89.
  4. Roberts CL, Rushworth SL, Richman E, Rhodes JM. Hypothesis: Increased consumption of emulsifiers as an explanation for the rising incidence of Crohn’s disease. J Crohns Colitis. 2013 May;7(4):338-41.
  5. Chassaing B, et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 2015 Mar 5;519(7541):92-6
  6. Martino JV, Van Limbergen J, Cahill LE. The Role of Carrageenan and Carboxymethylcellulose in the Development of Intestinal Inflammation. Front Pediatr. 2017 May 1;5:96.
  7. Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, Maza O, Israeli D, Zmora N, Gilad S, Weinberger A, Kuperman Y, Harmelin A, Kolodkin-Gal I, Shapiro H, Halpern Z, Segal E, Elinav E. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014 Oct 9;514(7521):181-6.
  8. Bian X, Chi L, Gao B, Tu P, Ru H, Lu K. The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in CD-1 mice. PLoS One. 2017 Jun 8;12(6):e0178426.
  9. Bian X, Tu P, Chi L, Gao B, Ru H, Lu K. Saccharin induced liver inflammation in mice by altering the gut microbiota and its metabolic functions. Food Chem Toxicol. 2017 May 1. pii: S0278-6915(17)30223-5.
  10. Nickerson KP, et al. Deregulation of intestinal anti-microbial defense by the dietary additive, maltodextrin. Gut Microbes. 2015;6(1):78-8
  11. Lerner A, Aminov R, Matthias T. Transglutaminases in Dysbiosis As Potential Environmental Drivers of Autoimmunity. Front Microbiol. 2017 Jan 24;8:66.
  12. Tobacman JK. Review of harmful gastrointestinal effects of carrageenan in animal experiments. Environ Health Perspect. 2001 Oct;109(10):983-94.
  13. Bhattacharyya S, Shumard T, Xie H, Dodda A, Varady KA, Feferman L, Halline AG, Goldstein JL, Hanauer SB, Tobacman JK. A randomized trial of the effects of the no-carrageenan diet on ulcerative colitis disease activity. Nutr Healthy Aging. 2017 Mar 31;4(2):181-192.

LEARNING ZONE

Garner Thomson

Kelley JM et al. The Influence of the Patient-Clinician Relationship on Healthcare Outcomes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. PLOS ONE 2014, 9(6): e101191. https://doi.org/10.1371/journal.pone.0101191.

Pennebaker, James W (2013) The Secret Life of Pronouns: What Your Words Say About You. New York: Bloomsbury Publishing.

ANTHOCYANINS

Eur J Appl Physiol. 2017 Feb;117(2):247-254. doi: 10.1007/s00421-016-3512-x. Epub 2016 Dec 24. Cardiovascular function during supine rest in endurance-trained males with New Zealand blackcurrant: a dose-response study.

Cook MD, Myers SD, Gault ML, Edwards VC, Willems ME.

Nutrients. 2017 May 29;9(6). pii: E556. doi: 10.3390/nu9060556.

Blackcurrant Alters Physiological Responses and Femoral Artery Diameter during Sustained Isometric Contraction. Cook MD, Myers SD, Gault ML, Willems MET.

Br J Nutr. 2015 Jun 14;113(11):1697-703. doi: 10.1017/S0007114515001105. Epub 2015 Apr 22. Polyphenol-rich blackcurrant extract exerts hypocholesterolaemic and hypoglycaemic effects in mice fed a diet containing high fat and cholesterol.

Benn T, Kim B, Park YK, Yang Y, Pham TX, Ku CS, Farruggia C, Harness E, Smyth JA, Lee JY.

GUT
Ranjit Kumar, Nengjun Yi, Degui Zhi, Peter Eipers, Kelly T. Goldsmith, Paula Dixon, David K. Crossman, Michael R. Crowley, Elliot J. Lefkowitz, J. Martin Rodriguez, Casey D. Morrow. Identification of donor microbe species that colonize and persist long term in the recipient after faecal transplant for recurrent Clostridium difficile. npj Biofilms and Microbiomes, 2017; 3 (1) DOI: 10.1038/s41522-017-0020-7

Alissa C. Nicolucci, Megan P. Hume, Inés Martínez, Shyamchand Mayengbam, Jens Walter, Raylene A. Reimer. Prebiotic Reduces Body Fat and Alters Intestinal Microbiota in Children With Overweight or Obesity. Gastroenterology, 2017; DOI: 10.1053/j.gastro.2017.05.055.

Becattini et al. Commensal microbes provide first line defense against Listeria monocytogenes infection. J. Exp. Med, 2017 DOI: 10.1084/jem.20170495

Hao Wu, Eduardo Esteve, Valentina Tremaroli, Muhammad Tanweer Khan, Robert Caesar, Louise Mannerås-Holm, Marcus Ståhlman, Lisa M Olsson, Matteo Serino, Mercè Planas-Fèlix, Gemma Xifra, Josep M Mercader, David Torrents, Rémy Burcelin, Wifredo Ricart, Rosie Perkins, José Manuel Fernàndez-Real, Fredrik Bäckhed. Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug. Nature Medicine, 2017; DOI: 10.1038/nm.4345

Zehra Esra Ilhan, John K DiBaise, Nancy G Isern, David W Hoyt, Andrew K Marcus, Dae-Wook Kang, Michael D Crowell, Bruce E Rittmann, Rosa Krajmalnik-Brown. Distinctive microbiomes and metabolites linked with weight loss after gastric bypass, but not gastric banding. The ISME Journal, 2017; DOI: 10.1038/ismej.2017.71

The Gut Microbiota and Autism Spectrum Disorders. Front Cell Neurosci. 2017; 11: 120. Published online 2017 Apr 28. doi:  10.3389/fncel.2017.00120

PMCID: PMC5408485. Qinrui Li,1 Ying Han,1,* Angel Belle C. Dy,2 and Randi J. Hagerman.

Free online at: http://journal.frontiersin.org/article/10.3389/fncel.2017.00120/full.

Dr David Perlmutter comments from: Autism and Gut Bacteria – Hope Moving Forward at http://www.drperlmutter.com/autism-and-gut-bacteria-hope-moving-forward.

Buffington et al. Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring. Cell, 2016 DOI: 10.1016/j.cell.2016.06.001

PROSTATE

German New Medicine: http://germannewmedicine.ca/home.html

Dr Gilbert Renaud: http://recallhealing.com.

Dr Bruce Lipton: https://www.brucelipton.com/books/biology-of-belief

http://www.survivingprostatecancer.org/trailer.html

RESEARCH UPDATE

Irene Roncero-Ramos, Mónica Mendiola-Lanao, Margarita Pérez-Clavijo, Cristina Delgado-Andrade. Effect of different cooking methods on nutritional value and antioxidant activity of cultivated mushrooms. International Journal of Food Sciences and Nutrition, 2016; 68 (3): 287 DOI: 10.1080/09637486.2016.1244662

Microglia-dependent synapse loss in type I interferon-mediated lupus. Allison R. Bialas et al. Nature 2017, doi:10.1038/nature22821.

Stefan Amisten, Israa Mohammad Al-Amily, Arvind Soni, Ross Hawkes, Patricio Atanes, Shanta Jean Persaud, Patrik Rorsman, Albert Salehi. Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells. Endocrine Journal, 2017; 64 (3): 325 DOI: 10.1507/endocrj.EJ16-0338

Omowunmi Aibana, Molly F. Franke, Chuan-Chin Huang, Jerome T. Galea, Roger Calderon, Zibiao Zhang, Mercedes C. Becerra, Emily R. Smith, Alayne G. Ronnenberg, Carmen Contreras, Rosa Yataco, Leonid Lecca, Megan B. Murray. Impact of Vitamin A and Carotenoids on the Risk of Tuberculosis Progression. Clinical Infectious Diseases, 2017; DOI: 10.1093/cid/cix476

Kaixiong Ye, Feng Gao, David Wang, Ofer Bar-Yosef, Alon Keinan. Dietary adaptation of FADS genes in Europe varied across time and geography. Nature Ecology & Evolution, 2017; 1: 0167 DOI: 10.1038/s41559-017-0167

Santosh Kumar, Angela Downie Ruiz Velasco, Gracjan Michlewski. Oleic Acid Induces MiR-7 Processing through Remodeling of Pri-MiR-7/Protein Complex. Journal of Molecular Biology, 2017; 429 (11): 1638 DOI: 10.1016/j.jmb.2017.05.001

Weronica E. Ek, Elmar W. Tobi, Muhammad Ahsan, Erik Lampa, Erica Ponzi, Soterios A. Kyrtopoulos, Panagiotis Georgiadis, L.H Lumey, Bastiaan T. Heijmans, Maria Botsivali, Ingvar A. Bergdahl, Torgny Karlsson, Mathias Rask-Andersen, Domenico Palli, Erik Ingelsson, Åsa K. Hedman, Lena M. Nilsson, Paolo Vineis, Lars Lind, James M. Flanagan, Åsa Johansson. Tea and coffee consumption in relation to DNA methylation in four European cohorts. Human Molecular Genetics, 2017; DOI: 10.1093/hmg/ddx194

L Pizzuti et al. GLUT 1 receptor expression and circulating levels of fasting glucose in high grade serous ovarian cancer. Journal of Cell Physiology, May 2017 DOI: 10.1002/jcp.26023

Marta K. Zamroziewicz, Erick J. Paul, Chris E. Zwilling, Aron K. Barbey. Determinants of fluid intelligence in healthy aging: Omega-3 polyunsaturated fatty acid status and frontoparietal cortex structure. Nutritional Neuroscience, 2017; 1 DOI: 10.1080/1028415X.2017.1324357

 

 

June 2017

IHCAN June references

NEWS

  1. Aggarwal, T. Fojo, C. Chamberlain, C. Davis, R. Sullivan. Do patient access schemes for high-cost cancer drugs deliver value to society?—lessons from the NHS Cancer Drugs Fund. Annals of Oncology, 2017; DOI: 10.1093/annonc/mdx110.Flory T. Muanda, Odile Sheehy, Anick Bérard. Use of antibiotics during pregnancy and risk of spontaneous abortion. Canadian Medical Association Journal, 2017; 189 (17): E625 DOI: 10.1503/cmaj.161020

Nicholas S. Downing, Nilay D. Shah, Jenerius A. Aminawung et al. Postmarket Safety Events Among Novel Therapeutics Approved by the US Food and Drug Administration Between 2001 and 2010. JAMA, 2017 DOI: 10.1001/jama.2017.5150.

Lucas Morin, Davide L. Vetrano, Debora Rizzuto, Amaia Calderón-Larrañaga, Johan Fastbom, Kristina Johnell. Choosing Wisely? Measuring the Burden of Medications in Older Adults near the End of Life: Nationwide, Longitudinal Cohort Study. The American Journal of Medicine, 2017; DOI: 10.1016/j.amjmed.2017.02.028.

Silverman M, Povitz M, Sontrop JM, Li L, Richard L, Cejic S, Shariff SZ. Antibiotic prescribing for acute non-bacterial upper-respiratory infections in the elderly. Annals of Internal Medicine, 2017 DOI: 10.7326/M16-1131.

Rohit Loomba, Victor Seguritan, Weizhong Li, Tao Long, Niels Klitgord, Archana Bhatt, Parambir Singh Dulai, Cyrielle Caussy, Richele Bettencourt, Sarah K. Highlander, Marcus B. Jones, Claude B. Sirlin, Bernd Schnabl, Lauren Brinkac, Nicholas Schork, Chi-Hua Chen, David A. Brenner, William Biggs, Shibu Yooseph, J. Craig Venter, Karen E. Nelson. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Cell Metabolism, 2017; 25 (5): 1054 DOI: 10.1016/j.cmet.2017.04.001.

Daniela Barone, Letizia Cito, Giuseppina Tommonaro, Agnese Anna Abate, Danila Penon, Rocco De Prisco, Antonella Penon, Iris Maria Forte, Elisabetta Benedetti, Annamaria Cimini, Paola Indovina, Barbara Nicolaus, Francesca Pentimalli, Antonio Giordano. Antitumoral Potential, Antioxidant Activity and Carotenoid Content of Two Southern Italy Tomato Cultivars Extracts: San Marzano and Corbarino. Journal of Cellular Physiology, 2017; DOI: 10.1002/jcp.25995.

Oil-Based or Water-Based Contrast for Hysterosalpingography in Infertile Women

Kim Dreyer, et al, N ENgl J Med, May 18, 2017. DOI: 10.1056/NEJMoa1612337.

Nina Cabezas-Wallscheid, Florian Buettner, Pia Sommerkamp, Daniel Klimmeck, Luisa Ladel, Frederic B. Thalheimer, Daniel Pastor-Flores, Leticia P. Roma, Simon Renders, Petra Zeisberger, Adriana Przybylla, Katharina Schönberger, Roberta Scognamiglio, Sandro Altamura, Carolina M. Florian, Malak Fawaz, Dominik Vonficht, Melania Tesio, Paul Collier, Dinko Pavlinic, Hartmut Geiger, Timm Schroeder, Vladimir Benes, Tobias P. Dick, Michael A. Rieger, Oliver Stegle, Andreas Trumpp. Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy. Cell, 2017; DOI: 10.1016/j.cell.2017.04.018

SIBO – BEN BROWN

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6.             Ricci JE Júnior, Chebli LA, et al. Small-Intestinal Bacterial Overgrowth is Associated With Concurrent Intestinal Inflammation But Not With Systemic Inflammation in Crohn’s Disease Patients. J Clin Gastroenterol. 2017 Jan 27.

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8.             Teo M, Chung S, Chitti L, Tran C, Kritas S, Butler R, Cummins A. Small bowel bacterial overgrowth is a common cause of chronic diarrhea. J Gastroenterol Hepatol. 2004 Aug;19(8):904-9.9.             Losurdo G, Marra A, Shahini E, et al. Small intestinal bacterial overgrowth and celiac disease: A systematic review with pooled-data analysis. Neurogastroenterol Motil. 2017 Feb 12.10.         Signoretti M, Stigliano S, Valente R, Piciucchi M, Delle Fave G, Capurso G. Small intestinal bacterial overgrowth in patients with chronic pancreatitis. J Clin Gastroenterol. 2014 Nov-Dec;48 Suppl 1:S52-5. 11.         Therrien A, Bouchard S, Sidani S, et al. Prevalence of Small Intestinal Bacterial Overgrowth among Chronic Pancreatitis Patients: A Case-Control Study. Can J Gastroenterol Hepatol. 2016;2016:7424831.12.         Kim KM, Kim BT, Lee DJ, Park SB, Joo NS, Kim YS, Kim KN. Erosive esophagitis may be related to small intestinal bacterial overgrowth. Scand J Gastroenterol. 2012 May;47(5):493-8.

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18.         Weinstock LB, Fern SE, Duntley SP. Restless legs syndrome in patients with irritable bowel syndrome: response to small intestinal bacterial overgrowth therapy. Dig Dis Sci. 2008 May;53(5):1252-6.19.         Henriksson AE, Blomquist L, Nord CE, et al. Small intestinal bacterial overgrowth in patients with rheumatoid arthritis. Ann Rheum Dis. 1993 Jul;52(7):503-10.

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24.         Fialho A, Fialho A, Schenone A, Thota P, McCullough A, Shen B. Association between small intestinal bacterial overgrowth and deep vein thrombosis. Gastroenterol Rep (Oxf). 2016 Nov;4(4):299-303.25.         Cheng X, Zhang L, Xie NC, Xu HL, Lian YJ. Association between small-intestinal bacterial overgrowth and deep vein thrombosis in patients with spinal cord injuries. J Thromb Haemost. 2017 Feb;15(2):304-311.26.         Niu XL, Liu L, Song ZX, Li Q, Wang ZH, Zhang JL, Li HH. Prevalence of small intestinal bacterial overgrowth in Chinese patients with Parkinson’s disease. J Neural Transm (Vienna). 2016 Dec;123(12):1381-1386.27.         Zhang Y, Liu G, Duan Y, Han X, Dong H, Geng J. Prevalence of Small Intestinal  Bacterial Overgrowth in Multiple Sclerosis: a Case-Control Study from China. J Neuroimmunol. 2016 Dec 15;301:83-87. 28.         Quigley EM. Small intestinal bacterial overgrowth: what it is and what it is not. Curr Opin Gastroenterol. 2014 Mar;30(2):141-6. 29.         Krajicek EJ, Hansel SL. Small Intestinal Bacterial Overgrowth: A Primary Care Review. Mayo Clin Proc. 2016 Dec;91(12):1828-1833.

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31.         Miazga A, Osiński M, Cichy W, Żaba R. Current views on the etiopathogenesis, clinical manifestation, diagnostics, treatment and correlation with other nosological entities of SIBO. Adv Med Sci. 2015 Mar;60(1):118-24.32.         Deloose E, Tack J. Redefining the functional roles of the gastrointestinal migrating motor complex and motilin in small bacterial overgrowth and hunger signaling. Am J Physiol Gastrointest Liver Physiol. 2016 Feb 15;310(4):G228-33.33.         Deloose E, Janssen P, Depoortere I, Tack J. The migrating motor complex: control mechanisms and its role in health and disease. Nat Rev Gastroenterol Hepatol. 2012 Mar 27;9(5):271-85.

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35.         Ghoshal UC, Srivastava D, Verma A, Misra A. Slow transit constipation associated with excess methane production and its improvement following rifaximin therapy: a case report. J Neurogastroenterol Motil. 2011 Apr;17(2):185-8.36.         Pimentel M, Chatterjee S, Chow EJ, Park S, Kong Y. Neomycin improves constipation-predominant irritable bowel syndrome in a fashion that is dependent  on the presence of methane gas: subanalysis of a double-blind randomized controlled study. Dig Dis Sci. 2006 Aug;51(8):1297-301.37.         Pimentel M, Mathur R, Chang C. Gas and the microbiome. Curr Gastroenterol Rep. 2013 Dec;15(12):356.38.         Yin J, Levanon D, Chen JD. Inhibitory effects of stress on postprandial gastric myoelectrical activity and vagal tone in healthy subjects. Neurogastroenterol Motil. 2004 Dec;16(6):737-44.39.         Devanarayana NM, de Silva DG, de Silva HJ. Gastric myoelectrical and motor abnormalities in children and adolescents with functional recurrent abdominal pain. J Gastroenterol Hepatol. 2008 Nov;23(11):1672-7. 40.         Pimentel M, Morales W, Lezcano S, Sun-Chuan D, Low K, Yang J. Low-dose nocturnal tegaserod or erythromycin delays symptom recurrence after treatment of  irritable bowel syndrome based on presumed bacterial overgrowth. Gastroenterol Hepatol (N Y). 2009 Jun;5(6):435-42.41.         Madisch A, Vinson BR, Abdel-Aziz H, et al. Modulation of gastrointestinal motility beyond metoclopramide and domperidone: Pharmacological and clinical evidence for phytotherapy in functional gastrointestinal disorders. Wien Med Wochenschr. 2017 May;167(7-8):160-168

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43.         Beasley DE, Koltz AM, Lambert JE, Fierer N, Dunn RR. The Evolution of Stomach  Acidity and Its Relevance to the Human Microbiome. PLoS One. 2015 Jul 29;10(7):e0134116. 44.         Urita Y, Watanabe T, Maeda T, et al. Extensive atrophic gastritis linked to increased levels of intraluminal hydrogen gas. Hepatogastroenterology. 2008 Sep-Oct;55(86-87):1645-8.45.         Enko D, Kriegshäuser G. Functional (13)C-urea and glucose hydrogen/methane breath tests reveal significant association of small intestinal bacterial overgrowth in individuals with active Helicobacter pylori infection. Clin Biochem. 2017 Jan;50(1-2):46-49.46.         Lo WK, Chan WW. Proton pump inhibitor use and the risk of small intestinal bacterial overgrowth: a meta-analysis. Clin Gastroenterol Hepatol. 2013 May;11(5):483-90

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49.         Yago MR, Frymoyer AR, Smelick GS, et al. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7.

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51.         Capurso G, Signoretti M, Archibugi L, Stigliano S, Delle Fave G. Systematic review and meta-analysis: Small intestinal bacterial overgrowth in chronic pancreatitis. United European Gastroenterol J. 2016 Oct;4(5):697-705.52.         Leeds JS, Hopper AD, Sidhu R, et al. Some patients with irritable bowel syndrome may have exocrine pancreatic insufficiency. Clin Gastroenterol Hepatol. 2010 May;8(5):433-8.53.         Bures J, Cyrany J, Kohoutova D, et al. Small intestinal bacterial overgrowth syndrome. World J Gastroenterol. 2010 Jun 28;16(24):2978-90.54.         Domínguez-Muñoz JE. Pancreatic enzyme replacement therapy for pancreatic exocrine insufficiency: when is it indicated, what is the goal and how to do it?  Adv Med Sci. 2011;56(1):1-5.55.         Money ME, Walkowiak J, Virgilio C, Talley NJ. Pilot study: a randomised, double blind, placebo controlled trial of pancrealipase for the treatment of postprandial irritable bowel syndrome-diarrhoea. Frontline Gastroenterol. 2011 Jan;2(1):48-56.56.         David L, Babin A, Picos A, et al. Small Intestinal Bacterial Overgrowth is Associated with Intestinal Inflammation in the Irritable Bowel Syndrome. Clujul Med. 2014;87(3):163-5.57.         Ricci JE Júnior, Chebli LA,et al. Small-Intestinal Bacterial Overgrowth is Associated With Concurrent Intestinal Inflammation But Not With Systemic Inflammation in Crohn’s Disease Patients. J Clin Gastroenterol. 2017 Jan 27. doi: 10.1097/MCG.0000000000000803.[Epub ahead of print] 58.         Winter SE, Bäumler AJ. Dysbiosis in the inflamed intestine: chance favors the prepared microbe. Gut Microbes. 2014 Jan-Feb;5(1):71-3. 59.         Agus A, Denizot J, Thévenot J, Martinez-Medina M, Massier S, Sauvanet P, Bernalier-Donadille A, Denis S, Hofman P, Bonnet R, Billard E, Barnich N. Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation. Sci Rep. 2016 Jan 8;6:19032.

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61.         Zhong C, Qu C, Wang B, Liang S, Zeng B. Probiotics for Preventing and Treating Small Intestinal Bacterial Overgrowth: A Meta-Analysis and Systematic Review of Current Evidence. J Clin Gastroenterol. 2017 Apr;51(4):300-311.62.         Celiberto LS, Bedani R, Rossi EA, et al. Probiotics: The scientific evidence in the context of inflammatory bowel disease. Crit Rev Food Sci Nutr. 2017 Jun 13;57(9):1759-1768.63.         Ierardi E, Losurdo G, Sorrentino C, Giorgio F, Rossi G, Marinaro A, Romagno KR, Di Leo A, Principi M. Macronutrient intakes in obese subjects with or without small intestinal bacterial overgrowth: an alimentary survey. Scand J Gastroenterol. 2016 Mar;51(3):277-80.

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66.         Enko D, Halwachs-Baumann G, Stolba R, et al. Refining small intestinal bacterial overgrowth diagnosis by means of carbohydrate specificity: a proof-of-concept study. Therap Adv Gastroenterol. 2016 May;9(3):265-72.67.         Rezaie A, Pimentel M, Rao SS. How to Test and Treat Small Intestinal Bacterial Overgrowth: an Evidence-Based Approach. Curr Gastroenterol Rep. 2016 Feb;18(2):8.68.         Ciampa BP, Reyes Ramos E, Borum M, Doman DB. The Emerging Therapeutic Role of  Medical Foods for Gastrointestinal Disorders. Gastroenterol Hepatol (N Y). 2017 Feb;13(2):104-115. 69.         Pimentel M, Constantino T, Kong Y, et al. A 14-day elemental diet is highly effective in normalizing the lactulose breath test. Dig Dis Sci. 2004 Jan;49(1):73-7.

  1. Hunter J. Elemental diet and the nutritional treatment of Crohn’s disease. Gastroenterol Hepatol Bed Bench. 2015 Winter;8(1):4-5
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72.         Khanna R, MacDonald JK, Levesque BG. Peppermint oil for the treatment of irritable bowel syndrome: a systematic review and meta-analysis. J Clin Gastroenterol. 2014 Jul;48(6):505-12.

  1. Chedid V, Dhalla S, Clarke JO, et al. Herbal therapy is equivalent to rifaximin for the treatment of small intestinal bacterial overgrowth. Glob Adv Health Med. 2014 May;3(3):16-24.
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 Zhong C, Qu C, Wang B, et al. Probiotics for Preventing and Treating Small Intestinal Bacterial Overgrowth: A Meta-Analysis and Systematic Review of Current Evidence. J Clin Gastroenterol. 2017 Apr;51(4):300-311

 MYCOLOGY

Ahn WS, Kim DJ, Chae GT, Lee JM, Bae SM, Sin JI, Kim YW, Namkoong SE, Lee IP (2004). Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Int J Gynecol Cancer 14:589-94.

 

Chiu HF, Fu HY, Lu YY, Han YC, Shen YC, Venkatakrishnan K, Golovinskaia O, Wang CK (2017). Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers. Pharm Biol 55, 1041-1046.

Dai Yu-C, Yang Z-L, Cui B-K, et al (2009). Species diversity and utilization of medicinal mushrooms and fungi in China (review). Int J Med Mush:  11: 287−302.

Deng G, Lin H, Seidman A, Fornier M, D’Andrea G, Wesa K, Yeung S, Cunningham-Rundles S, Vickers AJ, Cassileth B (2002). A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects. J Cancer Res Clin Oncol  135(9):1215-21.

Ina K, Furuta R, Kataoka T, Kayukawa S, Ina H, Yoneda M (2016). Chemo-Immunotherapy Using Lentinan for the Treatment of Gastric Cancer with Liver Metastases. Med. Sci. 2016, 4(2), 8

Ivanova TS, Krupodorova TA, Barshteyn VY, Artamonova AB, Shlyakhovenko VA (2014). Anticancer substances of mushroom origin. Exp Oncol 36(2):58-66.

 

Jiang J1, Grieb B, Thyagarajan A, Sliva D. Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling. Int J Mol Med. 2008 May;21(5):577-84.

Kimura Y1, Kido T, Takaku T, Sumiyoshi M, Baba K. Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions. Cancer Sci. 2004 Sep;95(9):758-64.

Ulrike Lindequist, Timo H. J. Niedermeyer, and Wolf-Dieter Jülich. Evidence-Based Complementary and Alternative Medicine,Volume 2 (2005), Issue 3, Pages 285-299 http://dx.doi.org/10.1093/ecam/neh107

Ohwada S, Ogawa T, Makita F, Tanahashi Y, Ohya T, Tomizawa N, Satoh Y, Kobayashi I, Izumi M, Takeyoshi I, Hamada K, Minaguchi S, Togo Y, Toshihiko T, Koyama T, Kamio M (2006). Beneficial effects of protein-bound polysaccharide K plus tegafur/uracil in patients with stage II or III colorectal cancer: analysis of immunological parameters. Oncol Rep 15:861-8.

Okuno K, Uno K (2011). Efficacy of orally administered Lentinula edodes mycelia extract for advanced gastrointestinal cancer patients undergoing cancer chemotherapy: a pilot study. Asian Pac J Cancer Prev. 12(7):1671-4.

Patel S & Goyal A (2012). Recent developments in mushrooms as anti-cancer therapeutics: a review. 3 Biotech 2(1):1-15.

Shing MK, Leung TF, Chu YL, Li CY, Chik KW, Leung PC, Lee V, Yuen PM and Li CK (2008). Randomized, double-blind and placebo-controlled study of the immunomodulatory effects of Lingzhi in children with cancers. J Clin Oncol ASCO Vol 26, No 15S (May 20 Supplement), 2008: 1402

Sze DM, Chan GC (2009). Supplements for immune enhancement in hematologic malignancies. Hematology Am Soc Hematol Educ Program. 2009:313-9.

Torkelson CJ,  Sweet E, Martzen MR,  Sasagawa M, Wenner CA, Gay J, Putiri A, Standish LJ (2012). Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer. ISRN Oncol. 2012; 2012: 251632.

Wu X, Zeng J, Hu J, Liao Q, Zhou R, Zhang P, Chen Z (2013). Hepatoprotective effects of aqueous extract from lingzhi or Reishi medicinal mushroom Ganoderma lucidum (Higher Basidiomycetes) on α-Amanitin-induced liver injury in mice. Int J Med Mushrooms 15 383-391.

Wu SJ, Lu TM, Lai MN, Ng LT. Immunomodulatory activities of medicinal mushroom Grifola frondosa extract and its bioactive constituent. Am J Chin Med. 2013;41(1):131-44

Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X (2012). Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.

Zhao S, Gang Y, Fu G, Cheng J-X, Ynag BB & Peng C (2011). Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin. Int J Oncol 38, 1319-1327.

RESEARCH

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María-Antonia Serrano, Javier Cañada, Juan Carlos Moreno, Gonzalo Gurrea. ‘Solar ultraviolet doses and vitamin D in a northern mid-latitude’. Science of the Total Environment 574 (2017) 744–750.

Benjamin J. Andreone, Brian Wai Chow, Aleksandra Tata, Baptiste Lacoste, Ayal Ben-Zvi, Kevin Bullock, Amy A. Deik, David D. Ginty, Clary B. Clish, Chenghua Gu. Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. Neuron, 2017; 94 (3): 581 DOI: 10.1016/j.neuron.2017.03.043

Yun-Gi Kim, Kei Sakamoto, Sang-Uk Seo, Joseph M. Pickard, Merritt G. Gillilland, Nicholas A. Pudlo, Matthew Hoostal, Xue Li, Thomas D. Wang, Taylor Feehley, Andrew T. Stefka, Thomas M. Schmidt, Eric C. Martens, Shinji Fukuda, Naohiro Inohara, Cathryn R. Nagler, Gabriel Núñez. Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens. Science, 2017; 356 (6335): 315 DOI: 10.1126/science.aag2029

  1. Marm Kilpatrick, Andrew D. M. Dobson, Taal Levi, Daniel J. Salkeld, Andrea Swei, Howard S. Ginsberg, Anne Kjemtrup, Kerry A. Padgett, Per M. Jensen, Durland Fish, Nick H. Ogden, Maria A. Diuk-Wasser. Lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control. Philosophical Transactions of the Royal Society B: Biological Sciences, 2017; 372 (1722): 20160117 DOI: 10.1098/rstb.2016.0117

Stella C. Watson, Yan Liu, Robert B. Lund, Jenna R. Gettings, Shila K. Nordone, Christopher S. McMahan, Michael J. Yabsley. A Bayesian spatio-temporal model for forecasting the prevalence of antibodies to Borrelia burgdorferi, causative agent of Lyme disease, in domestic dogs within the contiguous United States. PLOS ONE, 2017; 12 (5): e0174428 DOI: 10.1371/journal.pone.0174428

Heather Greenlee, Melissa J. DuPont-Reyes, Lynda G. Balneaves, Linda E. Carlson, Misha R. Cohen, Gary Deng, Jillian A. Johnson, Matthew Mumber, Dugald Seely, Suzanna M. Zick, Lindsay M. Boyce, Debu Tripathy. Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment. CA: A Cancer Journal for Clinicians, 2017; DOI: 10.3322/caac.21397

Bice et al. Environmental Enrichment Induces Pericyte and IgA-Dependent Wound Repair and Lifespan Extension in a Colon Tumour Model. Cell Reports, April 2017 DOI: 10.1016/j.celrep.2017.04.006.

Wouter van Marken Lichtenbelt, Mark Hanssen, Hannah Pallubinsky, Boris Kingma, Lisje Schellen. Healthy excursions outside the thermal comfort zone. Building Research & Information, 2017; 1 DOI: 10.1080/09613218.2017.1307647.

Bojing Liu, Fang Fang, Nancy L. Pedersen, Annika Tillander, Jonas F. Ludvigsson, Anders Ekbom, Per Svenningsson, Honglei Chen, and Karin Wirdefeldt. Vagotomy and Parkinson disease: A Swedish register–based matched-cohort study. Neurology, April 2017 DOI: 10.1212/WNL.0000000000003961.

  1. Heytens, A. De Sutter, L. Coorevits, P. Cools, J. Boelens, L. Van Simaey, T. Christiaens, M. Vaneechoutte, G. Claeys. Women with symptoms of a urinary tract infection but a negative urine culture: PCR-based quantification of Escherichia coli suggests infection in most cases. Clinical Microbiology and Infection, 2017; DOI: 10.1016/j.cmi.2017.04.004.

Lactose Intolerance (LCT-13910C>T) Genotype Is Associated with Plasma 25-Hydroxyvitamin D Concentrations in Caucasians: A Mendelian Randomization Study,. Ohood Alharbi and Ahmed El-Sohemy*. J Nutrition 2017, doi: 10.3945/​jn.116.246108.

Jennifer S. Labus, Emily B. Hollister, Jonathan Jacobs, Kyleigh Kirbach, Numan Oezguen, Arpana Gupta, Jonathan Acosta, Ruth Ann Luna, Kjersti Aagaard, James Versalovic, Tor Savidge, Elaine Hsiao, Kirsten Tillisch, Emeran A. Mayer. Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome. Microbiome, 2017; 5 (1) DOI: 10.1186/s40168-017-0260-z Open Access: https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-017-0260-z.

 

May 2017

PROF GEORGE LEWITH
Lewith, GT; Watkins AD; Hyland ME; et al. (March 2002). “Use of ultramolecular potencies of allergen to treat asthmatic people allergic to house dust mite: double blind randomised controlled clinical trial” (PDF). BMJ. 324 (7336): 520–520. doi:10.1136/bmj.324.7336.520.

Brien, Sarah; Lewith, George; Bryant, Trevor (August 2003). “Ultramolecular homeopathy has no observable clinical effects. A randomized, double-blind, placebo-controlled proving trial of Belladonna 30C” (PDF). British Journal of Clinical Pharmacology. 56 (5): 562–568. doi:10.1046/j.1365-2125.2003.01900.x. 

Brien SB, Lachance L, Prescott P, et al. (June 2011). “Homeopathy has clinical benefits in rheumatoid arthritis patients which are attributable to the consultation process not the homeopathic remedy. A randomised controlled clinical trial”. Rheumatology 50 (6): 1070-82. doi:10.1093/rheumatology/keq234.

Sunderajhan Sekar et al. Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats. Scientific Reports 7, Article number: 46457 (2017), doi:10.1038/srep46457.

Anika K Smith, Alex R Wade, Kirsty EH Penkman, Daniel H Baker. Dietary modulation of cortical excitation and inhibition. Journal of Psychopharmacology, 2017; 026988111769961 DOI: 10.1177/0269881117699613

BEN BROWN

  1. Kurokawa I, Danby FW, Ju Q, et al. New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol. 2009 Oct;18(10):821-32.
  2. Zouboulis CC, Jourdan E, Picardo M. Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions. J Eur Acad Dermatol Venereol. 2014 May;28(5):527-32.
  3. Oudenhoven MD, Kinney MA, McShane DB, Burkhart CN, Morrell DS. Adverse effects of acne medications: recognition and management. Am J Clin Dermatol. 2015 Aug;16(4):231-42.
  4. Gollnick HP. From new findings in acne pathogenesis to new approaches in

treatment. J Eur Acad Dermatol Venereol. 2015 Jun;29 Suppl 5:1-7.

  1. [1]Melnik BC. Linking diet to acne metabolomics, inflammation, and comedogenesis: an update. Clin Cosmet Investig Dermatol. 2015 Jul 15;8:371-88.
  2. [1] Bowe WP, Logan AC. Acne vulgaris, probiotics and the gut-brain-skin axis -back to the future? Gut Pathog. 2011 Jan 31;3(1):1.
  3. [1] Bowe W, Patel NB, Logan AC. Acne vulgaris, probiotics and the gut-brain-skin axis: from anecdote to translational medicine. Benef Microbes. 2014 Jun 1;5(2):185-99.
  4. [1] Kim J, Ko Y, Park YK, et al. Dietary effect of lactoferrin-enriched fermented milk on skin surface lipid and clinical improvement of acne vulgaris. Nutrition. 2010 Sep;26(9):902-9.
  5. [1] Jung GW, Tse JE, Guiha I,et al. Prospective, randomized, open-label trial comparing the safety, efficacy, and tolerability of an acne treatment regimen with and without a probiotic supplement and minocycline in subjects with mild to moderate acne. J Cutan Med Surg. 2013 Mar-Apr;17(2):114-22.
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  7. [1] Bowe WP, Patel N, Logan AC. Acne vulgaris: the role of oxidative stress and the potential therapeutic value of local and systemic antioxidants. J Drugs Dermatol. 2012 Jun;11(6):742-6.
  8. [1] Bowe WP, Logan AC. Clinical implications of lipid peroxidation in acne

vulgaris: old wine in new bottles. Lipids Health Dis. 2010 Dec 9;9:141.

  1. [1] l-Shobaili HA, Alzolibani AA, Al Robaee AA, et al. Biochemical markers of oxidative and nitrosative stress in acne vulgaris: correlation with disease activity. J Clin Lab Anal. 2013 Jan;27(1):45-52.
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  3. [1] Sardana K, Garg VK. An observational study of methionine-bound zinc with

antioxidants for mild to moderate acne vulgaris. Dermatol Ther. 2010

Jul-Aug;23(4):411-8.

  1. [1] Działo M, Mierziak J, Korzun U, et al. The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders. Int J Mol Sci. 2016 Feb 18;17(2):160.
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  5. [1] Melnik BC, John SM, Plewig G. Acne: risk indicator for increased body mass index and insulin resistance. Acta Derm Venereol. 2013 Nov;93(6):644-9.
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  8. [1] Smith RN, Mann NJ, Braue A, et al. A low-glycemic-load diet improves symptoms in acne vulgaris patients: a randomized controlled trial. Am J Clin Nutr. 2007 Jul;86(1):107-15.
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high-protein, low glycemic-load diet versus a conventional, high glycemic-load diet on biochemical parameters associated with acne vulgaris: a randomized, investigator-masked, controlled trial. J Am Acad Dermatol. 2007 Aug;57(2):247-56.

  1. [1] Smith RN, Braue A, Varigos GA, et al. The effect of a low glycemic load diet on acne vulgaris and the fatty acid composition of skin surface triglycerides. J Dermatol Sci. 2008 Apr;50(1):41-52.
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  11. [1] Simonart T. Acne and whey protein supplementation among bodybuilders. Dermatology. 2012;225(3):256-8.
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2011;67:131-45.

  1. [1] Hoyt G, Hickey MS, Cordain L. Dissociation of the glycaemic and insulinaemic responses to whole and skimmed milk. Br J Nutr. 2005 Feb;93(2):175-7.
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43.         [1] Bhate K, Williams HC. Epidemiology of acne vulgaris. Br J Dermatol. 2013 Mar;168(3):474-85.44.         [1] Holzmann R, Shakery K. Postadolescent acne in females. Skin Pharmacol Physiol. 2014;27 Suppl 1:3-8.45.         [1] Gieler U, Gieler T, Kupfer JP. Acne and quality of life – impact andmanagement. J Eur Acad Dermatol Venereol. 2015 Jun;29 Suppl 4:12-4.46.         [1] Williams HC, Dellavalle RP, Garner S. Acne vulgaris. Lancet. 2012 Jan28;379(9813):361-72.

  1. [1] Picardo M, Eichenfield LF, Tan J. Acne and Rosacea. Dermatol Ther (Heidelb). 2017 Jan;7(Suppl 1):43-52.

 

PROBIOTICS RESEARCH UPDATE

 

Emily G. Severance et al. Probiotic normalization of Candida albicans in schizophrenia: A randomized, placebo-controlled, longitudinal pilot study. Brain, Behavior, and Immunity, 2017; 62: 41 DOI: 10.1016/j.bbi.2016.11.019.

 

Emily G Severance et al. Candida albicans exposures, sex specificity and cognitive deficits in schizophrenia and bipolar disorder. npj Schizophrenia, 2016; 2: 16018 DOI: 10.1038/npjschz.2016.18.

 

Choi JW et al. Kefir prevented excess fat accumulation in diet-induced obese mice. Biosci Biotechnol Biochem. 2017 May; 81(5):958-965. doi: 10.1080/09168451.2016.1258984.

Netusha Thevaranjan et al. Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction. Cell Host & Microbe, 2017; 21 (4): 455 DOI: 10.1016/j.chom.2017.03.002

Vanessa D. de Mello et al. Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study. Scientific Reports, 2017; 7: 46337 DOI: 10.1038/srep46337

Chihaya Yamada et al. Molecular Insight into Evolution of Symbiosis between Breast-Fed Infants and a Member of the Human Gut Microbiome Bifidobacterium longum. Cell Chemical Biology, 2017; DOI: 10.1016/j.chembiol.2017.03.012

 

DETOX and PARASITES

Influence of a 10-Day Mimic of Our Ancient Lifestyle on Anthropometrics and Parameters of Metabolism and Inflammation: The “Study of Origin”

Leo Pruimboom, Begoña Ruiz-Núñez, Charles L. Raison, and Frits A. J. Muskiet. BioMed Research International, V 2016 (2016), Article ID 6935123, 9 pages

http://dx.doi.org/10.1155/2016/6935123.

 

 

New Scientist, March 29, 2017.  Chelsea Whyte: Lyme disease is set to explode and we still don’t have a vaccine

https://www.newscientist.com/article/mg23431195-800-lyme-disease-is-set-to-explode-and-you-cant-protect-yourself/ s

 

Bret M. Boyd, Julie M. Allen, Nam-phuong Nguyen, Pranjal Vachaspati, Zach Quicksall, Tandy Warnow, Lawrence Mugisha, Kevin P. Johnson, David L. Reed. Primates, lice and bacteria: speciation and genome evolution in the symbionts of hominid lice. Molecular Biology and Evolution, 2017; DOI: 10.1093/molbev/msx117

RESEARCH UPDATE

Setor Kwadzo Kunutsor, Michael Richard Whitehouse, Ashley William Blom, Jari Antero Laukkanen. Low serum magnesium levels are associated with increased risk of fractures: a long-term prospective cohort study. European Journal of Epidemiology, 2017; DOI: 10.1007/s10654-017-0242-2.

Thomas M. Stubbs, Marc Jan Bonder, Anne-Katrien Stark, Felix Krueger, Ferdinand von Meyenn, Oliver Stegle, Wolf Reik. Multi-tissue DNA methylation age predictor in mouse. Genome Biology, 2017; 18 (1) DOI: 10.1186/s13059-017-1203-5 .

Jamshid Tabeshpour, Bibi Marjan Razavi, Hossein Hosseinzadeh. Effects of Avocado (Persea americana ) on Metabolic Syndrome: A Comprehensive Systematic Review. Phytotherapy Research, 2017; DOI: 10.1002/ptr.5805.

Yung-Chih Chen, Rebecca L. Travers, Jean-Philippe Walhin, Javier T. Gonzalez, Francoise Koumanov, James A. Betts, Dylan Thompson. Feeding Influences Adipose Tissue Responses To Exercise In Overweight Men. American Journal of Physiology – Endocrinology And Metabolism, 2017; ajpendo.00006.2017 DOI: 10.1152/ajpendo.00006.2017.

Lamb DJ1, Reeves GL, Taylor A, Ferns GA.
Dietary copper supplementation reduces atherosclerosis in the cholesterol-fed rabbit. Atherosclerosis. 1999 Sep;146(1):33-43.

William G. Elder, Niki Munk, Margaret M. Love, Geza G. Bruckner, Kathryn E. Stewart, Kevin Pearce. Real-World Massage Therapy Produces Meaningful Effectiveness Signal for Primary Care Patients with Chronic Low Back Pain: Results of a Repeated Measures Cohort Study. Pain Medicine, 2017; DOI: 10.1093/pm/pnw347

Omar M. El-Halfawy, Javier Klett, Rebecca J. Ingram, Slade A. Loutet, Michael E. P. Murphy, Sonsoles Martín-Santamaría, Miguel A. Valvano. Antibiotic Capture by Bacterial Lipocalins Uncovers an Extracellular Mechanism of Intrinsic Antibiotic Resistance. mBio, 2017; 8 (2): e00225-17 DOI: 10.1128/mBio.00225-17.

Daniel Brugger, Wilhelm M Windisch. Short-Term Subclinical Zinc Deficiency in Weaned Piglets Affects Cardiac Redox Metabolism and Zinc Concentration. The Journal of Nutrition, 2017; 147 (4): 521 DOI: 10.3945/jn.116.240804

Zinc and the eye:
1 “Zinc,” June 2015, http://lpi.oregonstate.edu/mic/minerals/zinc

2 “Review: Zinc’s Functional Significance in the Vertebrate Retina,” July 2014, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119231/

3 “Study Shows New Role of Zinc in Optic Nerve Injury,” January 2017, http://www.news-medical.net/news/20170103/Study-shows-new-role-of-zinc-in-optic-nerve-injury.aspx.

4 “Mobile Zinc Increases Rapidly in the Retina After Optic Nerve Injury and Regulates Ganglion Cell Survival and Optic Nerve Regeneration,” January 2017, https://www.ncbi.nlm.nih.gov/pubmed/28049831.

Eveliina Munukka, Anniina Rintala, Raine Toivonen, Matts Nylund, Baoru Yang, Anna Takanen, Arno Hänninen, Jaana Vuopio, Pentti Huovinen, Sirpa Jalkanen, Satu Pekkala. Faecalibacterium prausnitzii treatment improves hepatic health and reduces adipose tissue inflammation in high-fat fed mice. The ISME Journal, 2017; DOI: 10.1038/ismej.2017.24

Joshua D. Schoenfeld, et al. O 2 − and H 2 O 2 -Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. Cancer Cell, 2017; DOI: 10.1016/j.ccell.2017.02.018

April 2017

IHCAN April references

NEWS

B VITS

Jia Zhong et al. B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial. PNAS 2017 ; published ahead of print March 13, 2017,

HELEN MONK on BANT Supervision

  1. Despenser S (2011) What is Supervision? British Association for Counselling and Psychotherapy (BACP).
  2. Hawkins P Shohet R and Hawkins R (2012) Supervision In The Helping Professions Open University Press; 4th edition.

BEN BROWN – PSORIASIS

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2.             Nestle FO, Kaplan DH, Barker J. Psoriasis. N Engl J Med. 2009 Jul 30;361(5):496-509.3.             Hedrich CM. Shaping the spectrum – From autoinflammation to autoimmunity. Clin Immunol. 2016 Apr;165:21-8.4.             Christophers E, Metzler G, Röcken M. Bimodal immune activation in psoriasis. Br J Dermatol. 2014 Jan;170(1):59-65.5.             Griffiths CE, Barker JN. Pathogenesis and clinical features of psoriasis. Lancet. 2007 Jul 21;370(9583):263-71. 6.             Oliveira Mde F, Rocha Bde O, Duarte GV. Psoriasis: classical and emerging comorbidities. An Bras Dermatol. 2015 Jan-Feb;90(1):9-20.7.             Lotti T, Hercogova J, Prignano F. The concept of psoriatic disease: can cutaneous psoriasis any longer be separated by the systemic comorbidities? Dermatol Ther. 2010 Mar-Apr;23(2):119-22.8.             Lebwohl M. Psoriasis. Lancet. 2003 Apr 5;361(9364):1197-204.9.             Griffiths CE, van de Kerkhof P, Czarnecka-Operacz M. Psoriasis and Atopic Dermatitis. Dermatol Ther (Heidelb). 2017 Jan;7(Suppl 1):31-41.Barrea L, Nappi F, Di Somma C, et al. Environmental Risk Factors in Psoriasis: The Point of View of the Nutritionist. Int J Environ Res Public Health. 2016 Jul 22;13(5).10.         Kim D, Yoo SA, Kim WU. Gut microbiota in autoimmunity: potential for clinical  applications. Arch Pharm Res. 2016 Nov;39(11):1565-1576.11.         Fry L, Baker BS, Powles AV, Engstrand L. Psoriasis is not an autoimmune disease? Exp Dermatol. 2015 Apr;24(4):241-4. 12.         Zákostelská Z, Málková J, Klimešová K, et al. Intestinal Microbiota Promotes Psoriasis-Like Skin Inflammation by Enhancing Th17 Response. PLoS One. 2016 Jul 19;11(7):e0159539.13.         Groeger D, O’Mahony L, Murphy EF, et al. Bifidobacterium infantis 35624 modulates host inflammatory processes  beyond the gut. Gut Microbes. 2013 Jul-Aug;4(4):325-39.14.         Pietrzak A, Jastrzebska I, Chodorowska G, et al. Psoriasis vulgaris and digestive system disorders: is there a linkage? Folia Histochem Cytobiol. 2009 Jan;47(3):517-24.15.         Bowe W, Patel NB, Logan AC. Acne vulgaris, probiotics and the gut-brain-skin axis: from anecdote to translational medicine. Benef Microbes. 2014 Jun 1;5(2):185-99.16.         Festi D, Schiumerini R, Eusebi LH, et al. Gut microbiota and metabolic syndrome. World J Gastroenterol. 2014 Nov 21;20(43):16079-94.17.         Humbert P, Bidet A, Treffel P, et al. Intestinal permeability in patients with psoriasis. J Dermatol Sci. 1991 Jul;2(4):324-6.18.         Brown AC, Hairfield M, Richards DG, et al. Medical nutrition therapy as a potential complementary treatment for psoriasis–five case reports. Altern Med Rev. 2004 Sep;9(3):297-307.

  1. Alwan W, Nestle FO. Pathogenesis and treatment of psoriasis: exploiting pathophysiological pathways for precision medicine. Clin Exp Rheumatol 2015;33(5 Suppl 93): S2–6.

20.         Coates LC, FitzGerald O, Helliwell PS, Paul C. Psoriasis, psoriatic arthritis, and rheumatoid arthritis: Is all inflammation the same? Semin Arthritis Rheum. 2016 Dec;46(3):291-304. 21.         Sticherling M. Psoriasis and autoimmunity. Autoimmun Rev. 2016 Dec;15(12):1167-1170.22.         Deng Y, Chang C, Lu Q. The Inflammatory Response in Psoriasis: a Comprehensive Review. Clin Rev Allergy Immunol. 2016 Jun;50(3):377-89.23.         Puig L. The role of IL 23 in the treatment of psoriasis. Expert Rev Clin Immunol. 2017 Feb 6. doi: 10.1080/1744666X.2017.1292137. [Epub ahead of print]24.         Owczarczyk-Saczonek A, Placek W. Interleukin-17 as a factor linking the pathogenesis of psoriasis with metabolic disorders. Int J Dermatol. 2017 Mar;56(3):260-268.25.         Eder L, Jayakar J, Pollock R, et al. Serum adipokines in patients with psoriatic arthritis and psoriasis alone and their correlation with disease activity. Ann Rheum Dis. 2013  Dec;72(12):1956-61.26.         Calder PC, Albers R, Antoine JM, et al. Inflammatory disease processes and interactions with nutrition. Br J Nutr. 2009 May;101 Suppl 1:S1-45.27.         Takeshita J, Grewal S, Langan SM, Mehta NN, Ogdie A, Van Voorhees AS, Gelfand  JM. Psoriasis and comorbid diseases: Implications for management. J Am Acad Dermatol. 2017 Mar;76(3):393-403.28.         Antiga E, Bonciolini V, Volpi W, Del Bianco E, Caproni M. Oral Curcumin (Meriva) Is Effective as an Adjuvant Treatment and Is Able to Reduce IL-22 Serum  Levels in Patients with Psoriasis Vulgaris. Biomed Res Int. 2015;2015:283634.29.         Beygi S, Lajevardi V, Abedini R. C-reactive protein in psoriasis: a review of  the literature. J Eur Acad Dermatol Venereol. 2014 Jun;28(6):700-11.30.         Peluso I, Cavaliere A, Palmery M. Plasma total antioxidant capacity and peroxidation biomarkers in psoriasis. J Biomed Sci. 2016 Jul 4;23(1):52.31.         Zhou Q, Mrowietz U, Rostami-Yazdi M. Oxidative stress in the pathogenesis of psoriasis. Free Radic Biol Med. 2009 Oct 1;47(7):891-905.32.         Trouba KJ, Hamadeh HK, Amin RP, Germolec DR. Oxidative stress and its role in  skin disease. Antioxid Redox Signal. 2002 Aug;4(4):665-73.33.         Lin X, Huang T. Oxidative stress in psoriasis and potential therapeutic use of antioxidants. Free Radic Res. 2016 Jun;50(6):585-95.34.         Kharaeva Z, Gostova E, De Luca C, et al. Clinical and biochemical effects of coenzyme Q(10), vitamin E, and selenium supplementation to psoriasis patients. Nutrition. 2009 Mar;25(3):295-302.35.         Fairris GM, Lloyd B, Hinks L, Perkins PJ, Clayton BE. The effect of supplementation with selenium and vitamin E in psoriasis. Ann Clin Biochem. 1989  Jan;26 ( Pt 1):83-8.36.         Harvima RJ, Jägerroos H, Kajander EO, et al. Screening of effects of selenomethionine-enriched yeast supplementation on various immunological and chemical parameters of skin and blood in psoriatic patients. Acta Derm Venereol.  1993 Apr;73(2):88-91.37.         Serwin AB, Wasowicz W, Chodynicka B. Selenium supplementation, soluble tumor necrosis factor-alpha receptor type 1, and C-reactive protein during psoriasis therapy with narrowband ultraviolet B. Nutrition. 2006 Sep;22(9):860-4.38.         Gyldenløve M, Storgaard H, Holst JJ, et al. Patients with psoriasis are insulin resistant. J Am Acad Dermatol. 2015 Apr;72(4):599-605.39.         Praveenkumar U, Ganguly S, Ray L,et al. Prevalence of40.         Metabolic Syndrome in Psoriasis Patients and its Relation to Disease Duration: A  Hospital Based Case-Control Study. J Clin Diagn Res. 2016 Feb;10(2):WC01-5. 41.         Napolitano M, Megna M, Monfrecola G. Insulin resistance and skin diseases. ScientificWorldJournal. 2015;2015:479354.42.         Boehncke S, Thaci D, Beschmann H,et al. Psoriasis patients show signs of insulin resistance. Br J Dermatol.  2007 Dec;157(6):1249-51.43.         Moore AF, Soper T, Jones N,et al. Psoriatic exacerbation associated with insulin therapy. Diabetes Care. 2008 May;31(5):e31.44.         Wu CY, Shieh JJ, Shen JL,et al. Association between antidiabetic drugs and psoriasis risk in diabetic patients: results from a nationwide nested case-control study in Taiwan. J Am Acad Dermatol. 2015 Jan;72(1):123-30.

  1. Brewer G, Turkay A, Yuzbasiyan-Gurkan V, et al. Chromium supplementation and insulin sensitivity in psoriasis. J Am Coll Nutr 1993;12:588

46.         Moon HS, Mizara A, McBride SR. Psoriasis and psycho-dermatology. Dermatol Ther (Heidelb). 2013 Dec;3(2):117-30.47.         Hunter HJ, Griffiths CE, Kleyn CE. Does psychosocial stress play a role in the exacerbation of psoriasis? Br J Dermatol. 2013 Nov;169(5):965-74.

  1. Pacan P, Szepietowski JC, Kiejna A. Stressful life events and depression in patients suffering from psoriasis vulgaris. Dermatol Psychosom 2003; 4: 142-5

49.         Lakshmy S, Balasundaram S, Sarkar S,et al. A Cross-sectional Study of Prevalence and Implications of Depression and Anxiety in Psoriasis. Indian J Psychol Med. 2015 Oct-Dec;37(4):434-40.50.         de Brouwer SJ, van Middendorp H, Stormink C, et al. The psychophysiological stress response in psoriasis and rheumatoid arthritis. Br J Dermatol. 2014 Apr;170(4):824-31.51.         Richards HL, Ray DW, Kirby B, et al. Response of the hypothalamic-pituitary-adrenal axis to psychological stress in patients with psoriasis. Br J Dermatol. 2005 Dec;153(6):1114-20. 52.         Brunoni AR, Santos IS, Sabbag C, et al. Psoriasis severity and hypothalamic-pituitary-adrenal axis function: results from the CALIPSO study. Braz J Med Biol Res. 2014 Dec;47(12):1102-6.53.         Evers AW, Verhoeven EW, Kraaimaat FW, det al. How stress gets under the skin: cortisol and stress reactivity in psoriasis. Br J Dermatol. 2010 Nov;163(5):986-91.54.         Amatya B, El-Nour H, Holst M, et al. Expression of tachykinins and their receptors in plaque psoriasis with pruritus. Br J Dermatol. 2011 May;164(5):1023-9.55.         Schwartz J, Evers AW, Bundy C, Kimball AB. Getting under the Skin: Report from the International Psoriasis Council Workshop on the Role of Stress in Psoriasis.  Front Psychol. 2016 Feb 2;7:87.56.         Barrea L, Macchia PE, Tarantino G, et al. Nutrition: a key environmental dietary factor in clinical severity and cardio-metabolic risk in psoriatic male patients evaluated by 7-day  food-frequency questionnaire. J Transl Med. 2015 Sep 16;13:303.

  1. Barrea L, Balato N, Di Somma C, et al. Nutrition and psoriasis: is there any association between the severity of the disease and adherence to the Mediterranean diet?J Transl Med. 2015;13:18–27

58.         Festugato M. Pilot study on which foods should be avoided by patients with psoriasis. An Bras Dermatol. 2011 Nov-Dec;86(6):1103-8.59.         Wong AP, Kalinovsky T, Niedzwiecki A, Rath M. Efficacy of nutritional treatment in patients with psoriasis: A case report. Exp Ther Med. 2015 Sep;10(3):1071-1073. 60.         Carrascosa JM, Rocamora V, Fernandez-Torres RM, et al. Obesity and psoriasis: inflammatory nature of obesity, relationship between psoriasis and obesity, and therapeutic implications. Actas Dermosifiliogr. 2014 Jan-Feb;105(1):31-44.61.         Upala S, Sanguankeo A. Effect of lifestyle weight loss intervention on disease severity in patients with psoriasis: a systematic review and meta-analysis. Int J Obes (Lond). 2015 Aug;39(8):1197-202.62.         Jensen P, Zachariae C, Christensen R, et al. Effect of weight loss on the severity of psoriasis: a randomized clinical study. JAMA Dermatol. 2013 Jul;149(7):795-801.63.         Rucević I, Perl A, Barisić-Drusko V, Adam-Perl M. The role of the low energy diet in psoriasis vulgaris treatment. Coll Antropol. 2003;27 Suppl 1:41-8.64.         Guida B, Napoleone A, Trio R, et al. Energy-restricted, n-3 polyunsaturated fatty acids-rich diet improves the clinical response to immuno-modulating drugs in obese patients with plaque-type psoriasis: a randomized control clinical trial. Clin Nutr. 2014 Jun;33(3):399-405.65.         Bhatia BK, Millsop JW, Debbaneh M, et al. Diet and psoriasis, part II: celiac disease and role of a gluten-free diet. J Am Acad Dermatol. 2014  Aug;71(2):350-8.66.         Ungprasert P, Wijarnpreecha K, Kittanamongkolchai W. Psoriasis and Risk of Celiac Disease: A Systematic Review and Meta-analysis. Indian J Dermatol. 2017 Jan-Feb;62(1):41-46.67.         Akbulut S, Gür G, Topal F, et al. Coeliac disease-associated antibodies in psoriasis. Ann Dermatol. 2013 Aug;25(3):298-303.68.         Bonciolini V, Bianchi B, Del Bianco E, et al. Cutaneous Manifestations of Non-Celiac Gluten Sensitivity: Clinical Histological and Immunopathological Features. Nutrients. 2015 Sep 15;7(9):7798-805.

  1. Michaëlsson G, Ahs S, Hammarström I, et al. Gluten-free diet in psoriasis patients with antibodies to gliadin results in decreased expression of tissue transglutaminase and fewer Ki67+ cells in the dermis.Acta Derm Venereol. 2003;83:425–9.
  2. Addolorato G, Parente A, de Lorenzi G, et al. Rapid regression of psoriasis in a coeliac patient after gluten-free diet. A case report and review of the literature. 2003;68:9–12.
  3. Frikha F, Snoussi M, Bahloul Z. Osteomalacia associated with cutaneous psoriasis as the presenting feature of coeliac disease: a case report.Pan Afr Med J. 2012;11:58.

72.         De Bastiani R, Gabrielli M, Lora L, et al. Association between coeliac disease and psoriasis: Italian primary care multicentre study. Dermatology. 2015;230(2):156-60.

  1. Michaëlsson G, Gerdén B, Hagforsen E, et al. Psoriasis patients with antibodies to gliadin can be improved by a gluten-free diet. Br J Dermatol. 2000 Jan;142(1):44-51.

RESEARCH

Gloria Bonuccelli, Ernestina Marianna De Francesco, Rianne de Boer, Herbert B. Tanowitz, Michael P. Lisanti. NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Identification of Vitamin C and CAPE as natural products targeting “stemness”. Oncotarget, 2015; DOI: 10.18632/oncotarget.15400.

Hillard Kaplan, Randall C Thompson, Benjamin C Trumble, L Samuel Wann, Adel H Allam, Bret Beheim, Bruno Frohlich, M Linda Sutherland, James D Sutherland, Jonathan Stieglitz, Daniel Eid Rodriguez, David E Michalik, Chris J Rowan, Guido P Lombardi, Ram Bedi, Angela R Garcia, James K Min, Jagat Narula, Caleb E Finch, Michael Gurven, Gregory S Thomas. Coronary atherosclerosis in indigenous South American Tsimane: a cross-sectional cohort study. The Lancet, 2017; DOI: 10.1016/S0140-6736(17)30752-3.

Mark Jones, Susan Tett, Geeske M. E. E. Peeters, Gita D. Mishra, Annette Dobson. New-Onset Diabetes After Statin Exposure in Elderly Women: The Australian Longitudinal Study on Women’s Health. Drugs & Aging, 2017; 34 (3): 203 DOI: 10.1007/s40266-017-0435-0.

Emma Lefrançais, Guadalupe Ortiz-Muñoz, Axelle Caudrillier, Beñat Mallavia, Fengchun Liu, David M. Sayah, Emily E. Thornton, Mark B. Headley, Tovo David, Shaun R. Coughlin, Matthew F. Krummel, Andrew D. Leavitt, Emmanuelle Passegué, Mark R. Looney. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature, 2017; DOI: 10.1038/nature21706

Didier Ndeh, Artur Rogowski, Alan Cartmell, Ana S. Luis, Arnaud Baslé, Joseph Gray, Immacolata Venditto, Jonathon Briggs, Xiaoyang Zhang, Aurore Labourel, Nicolas Terrapon, Fanny Buffetto, Sergey Nepogodiev, Yao Xiao, Robert A. Field, Yanping Zhu, Malcolm A. O’Neill, Breeanna R. Urbanowicz, William S. York, Gideon J. Davies, D. Wade Abbott, Marie-Christine Ralet, Eric C. Martens, Bernard Henrissat, Harry J. Gilbert. Complex pectin metabolism by gut bacteria reveals novel catalytic functions. Nature, 2017; DOI: 10.1038/nature21725.

Simon Nicolas, Vincent Blasco‐Baque, Audren Fournel, Jerome Gilleron, Pascale Klopp, Aurelie Waget, Franck Ceppo, Alysson Marlin, Roshan Padmanabhan, Jason S Iacovoni, François Tercé, Patrice D Cani, Jean‐François Tanti, Remy Burcelin, Claude Knauf, Mireille Cormont, Matteo Serino. Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism. Molecular Systems Biology, 2017; 13 (3): 921 DOI: 10.15252/msb.20167356

Stuart G. Snowden, Amera A. Ebshiana, Abdul Hye, Yang An, Olga Pletnikova, Richard O’Brien, John Troncoso, Cristina Legido-Quigley, Madhav Thambisetty. Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study. PLOS Medicine, 2017; 14 (3): e1002266 DOI: 10.1371/journal.pmed.1002266

Stephanie Vuillermot, Wei Luan, Urs Meyer, Darryl Eyles. Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation. Molecular Autism, 2017; 8 (1) DOI: 10.1186/s13229-017-0125-0

Tatiana E. Salazar et al, Electroacupuncture Promotes CNS-Dependent Release of Mesenchymal Stem Cells. STEM CELLS, 2017; DOI: 10.1002/stem.2613

March 2017

BEN BROWN Detoxification

  1. Liska D, Lyon M, Jones DS. Detoxification and biotransformational imbalances. Explore (NY). 2006 Mar;2(2):122-40.

2.             Cline JC. Nutritional aspects of detoxification in clinical practice. Altern Ther Health Med. 2015 May-Jun;21(3):54-62.3.             Klein AV, Kiat H. Detox diets for toxin elimination and weight management: a critical review of the evidence. J Hum Nutr Diet. 2015 Dec;28(6):675-86.4.             Edwards TM, Myers JP. Environmental exposures and gene regulation in disease etiology. Environ Health Perspect. 2007 Sep;115(9):1264-70.5.             Crinnion WJ. The CDC fourth national report on human exposure to environmental chemicals: what it tells us about our toxic burden and how it assist environmental medicine physicians. Altern Med Rev. 2010 Jul;15(2):101-9.6.             Tyrrell J, Melzer D, Henley W, Galloway TS, Osborne NJ. Associations between socioeconomic status and environmental toxicant concentrations in adults in the USA: NHANES 2001-2010. Environ Int. 2013 Sep;59:328-35.7.             Di Renzo GC, Conry JA, Blake J, et al. International Federation of Gynecology and Obstetrics opinion on reproductive health impacts of exposure to toxic environmental chemicals. Int J Gynaecol Obstet. 2015 Dec;131(3):219-25.8.             Goldman LR, Koduru S. Chemicals in the environment and developmental toxicity  to children: a public health and policy perspective. Environ Health Perspect. 2000 Jun;108 Suppl 3:443-8.9.             Chevalier N, Fénichel P. Endocrine disruptors: new players in the pathophysiology of type 2 diabetes? Diabetes Metab. 2015 Apr;41(2):107-15.10.         Heindel JJ, Newbold R, Schug TT. Endocrine disruptors and obesity. Nat Rev Endocrinol. 2015 Nov;11(11):653-61. 11.         Zeliger HI. Lipophilic chemical exposure as a cause of cardiovascular disease. Interdiscip Toxicol. 2013 Jun;6(2):55-62.12.         Teitelbaum SL, Belpoggi F, Reinlib L. Advancing research on endocrine disrupting chemicals in breast cancer: Expert panel recommendations. Reprod Toxicol. 2015 Jul;54:141-7. 13.         Barragán-Martínez C, Speck-Hernández CA, Montoya-Ortiz G, Mantilla RD, Anaya JM, Rojas-Villarraga A. Organic solvents as risk factor for autoimmune diseases:  a systematic review and meta-analysis. PLoS One. 2012;7(12):e51506.14.         Brown BI. Chronic fatigue syndrome: a personalized integrative medicine approach. Altern Ther Health Med. 2014 Jan-Feb;20(1):29-40. 15.         Wang N, Zhou Y, Fu C, Wang H, Huang P, Wang B, Su M, Jiang F, Fang H, Zhao Q,  Chen Y, Jiang Q. Influence of Bisphenol A on Thyroid Volume and Structure Independent of Iodine in School Children. PLoS One. 2015 Oct 23;10(10):e0141248.16.         Akın L, Kendirci M, Narin F, Kurtoglu S, Saraymen R, Kondolot M, Koçak S, Elmali F. The endocrine disruptor bisphenol A may play a role in the aetiopathogenesis of polycystic ovary syndrome in adolescent girls. Acta Paediatr. 2015 Apr;104(4):e171-7. 17.         Anger DL, Foster WG. The link between environmental toxicant exposure and endometriosis. Front Biosci. 2008 Jan 1;13:1578-93.18.         Tzivian L, Winkler A, Dlugaj M, et al. Effect of long-term outdoor air pollution and noise on cognitive and  psychological functions in adults. Int J Hyg Environ Health. 2015 Jan;218(1):1-11.19.         Genuis SJ, Kelln KL. Toxicant exposure and bioaccumulation: a common and potentially reversible cause of cognitive dysfunction and dementia. Behav Neurol. 2015;2015:620143. 20.         Genuis SJ. Elimination of persistent toxicants from the human body. Hum Exp Toxicol. 2011 Jan;30(1):3-18. 21.         Jandacek RJ, Tso P. Factors affecting the storage and excretion of toxic lipophilic xenobiotics. Lipids. 2001 Dec;36(12):1289-305.22.         Jandacek RJ, Heubi JE, Buckley DD, Khoury JC, Turner WE, Sjödin A, Olson JR, Shelton C, Helms K, Bailey TD, Carter S, Tso P, Pavuk M. Reduction of the body burden of PCBs and DDE by dietary intervention in a randomized trial. J Nutr Biochem. 2014 Apr;25(4):483-8.

  1. Jandacek RJ, Genuis SJ. An assessment of the intestinal lumen as a site for intervention in reducing body burdens of organochlorine compounds. ScientificWorldJournal. 2013;2013:205621.

24.         Sato M, Kondoh M. Recent studies on metallothionein: protection against toxicity of heavy metals and oxygen free radicals. Tohoku J Exp Med. 2002 Jan;196(1):9-22.25.         Hu R, Hebbar V, Kim BR, Chen C, Winnik B, Buckley B, Soteropoulos P, Tolias P, Hart RP, Kong AN. In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat. J Pharmacol Exp Ther. 2004 Jul;310(1):263-71.26.         Swindell WR. Metallothionein and the biology of aging. Ageing Res Rev. 2011 Jan;10(1):132-45.27.         Lamb JJ, Konda VR, Quig DW, et al. A program consisting of a phytonutrient-rich medical food and an elimination diet ameliorated fibromyalgia symptoms and promoted toxic-element detoxification in a pilot trial. Altern Ther  Health Med. 2011 Mar-Apr;17(2):36-44.

  1. Ibrahim F, Halttunen T, Tahvonen R, Salminen S. 2006. Probiotic bacteria as potential detoxification tools: assessing their heavy metal binding isotherms.  J. Microbiol. 52:877–885. 10.1139/w06-043

29.         Breton J, Daniel C, Dewulf J, Pothion S, Froux N, Sauty M, Thomas P, Pot B, Foligné B. Gut microbiota limits heavy metals burden caused by chronic oral exposure. Toxicol Lett. 2013 Oct 24;222(2):132-8.30.         Trinder M, McDowell TW, Daisley BA, Ali SN, Leong HS, Sumarah MW, Reid G. Probiotic Lactobacillus rhamnosus Reduces Organophosphate Pesticide Absorption and Toxicity to Drosophila melanogaster. Appl Environ Microbiol. 2016 Sep 30;82(20):6204-6213. 31.         Bisanz JE, Enos MK, Mwanga JR, Changalucha J, Burton JP, Gloor GB, Reid G. Randomized open-label pilot study of the influence of probiotics and the gut microbiome on toxic metal levels in Tanzanian pregnant women and school children. MBio. 2014 Oct 7;5(5):e01580-14. doi: 10.1128/mBio.01580-14.

  1. Fariduddin AKM, Misbahuddin M, Manun MIR, Nahar N. Alcohol extract and residue of spirulina in the prevention of accumulation of arsenic in rats. Bang J Physiol Pharmacol 2001; 17:15-7.
  2. Tachino N, Guo D, Dashwood WM, Yamane S, Larsen R, Dashwood R. Mechanisms of the in vitro antimutagenic action of chlorophyllin against benzo[a]pyrene: studies of enzyme inhibition, molecular complex formation and degradation of the ultimate carcinogen. Mutat Res. 1994;308(2):191-203.
  3. Dashwood R, Yamane S, Larsen R. Study of the forces of stabilizing complexes between chlorophylls and heterocyclic amine mutagens. Environ Mol Mutagen. 1996;27(3):211-218
  4. Breinholt V, Schimerlik M, Dashwood R, Bailey G. Mechanisms of chlorophyllin anticarcinogenesis against aflatoxin B1: complex formation with the carcinogen. Chem Res Toxicol. 1995;8(4):506-514.
  5. Morita K, Ogata M, Hasegawa T. Chlorophyll derived from Chlorella inhibits dioxin absorption from the gastrointestinal tract and accelerates dioxin excretion in rats. Environ Health Perspect. 2001 Mar;109(3):289-94.
  6. Misbahuddin M, Islam AZ, Khandker S, et al. Efficacy of spirulina extract plus zinc in patients of chronic arsenic poisoning: a randomized placebo-controlled study. Clin Toxicol (Phila). 2006;44(2):135-41.
  7. Genuis SJ, Curtis L, Birkholz D. Gastrointestinal Elimination of Perfluorinated Compounds Using Cholestyramine and Chlorella pyrenoidosa. ISRN Toxicol. 2013 Sep 9;2013:657849.
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41.         Hodges RE, Minich DM. Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application. J Nutr Metab. 2015;2015:760689.42.         Kikuchi M, Ushida Y, Shiozawa H, et al. Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects. World J Gastroenterol. 2015 Nov 21;21(43):12457-67.43.         Yang H, Xu W, Zhou Z, Liu J, Li X, Chen L, Weng J, Yu Z. Curcumin attenuates urinary excretion of albumin in type II diabetic patients with enhancing nuclear  factor erythroid-derived 2-like 2 (Nrf2) system and repressing inflammatory signaling efficacies. Exp Clin Endocrinol Diabetes. 2015 Jun;123(6):360-7.44.         González-Guardia L, Yubero-Serrano EM, Delgado-Lista J, et al. Effects of the Mediterranean diet supplemented with coenzyme q10 on metabolomic profiles in elderly men and women. J Gerontol A Biol  Sci Med Sci. 2015 Jan;70(1):78-84.

  1. Brown BI. Nutritional Detoxification (article in preparation). 2017. Unpublished.

MITOCHONDRIA and IMMUNITY
Nicole Paulin, Yvonne Döring, Sander Kooijman, Xavier Blanchet, Joana R. Viola, Renske de Jong, Manuela Mandl, Jeffrey Hendrikse, Maximilian Schiener, Philipp von Hundelshausen, Anja Vogt, Christian Weber, Khalil Bdeir, Susanna M. Hofmann, Patrick C.N. Rensen, Maik Drechsler, Oliver Soehnlein. Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance. EBioMedicine, 2017; DOI: 10.1016/j.ebiom.2017.01.006

Maret G Traber, Eunice Mah, Scott W Leonard, Gerd Bobe, Richard S Bruno. Metabolic syndrome increases dietary α-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial. The American Journal of Clinical Nutrition, 2017; ajcn138495 DOI: 10.3945/ajcn.116.138495.

Martineau AR et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 2017; 356 doi: https://doi.org/10.1136/bmj.i6583

Naama Geva-Zatorsky, Esen Sefik, Lindsay Kua, Lesley Pasman, Tze Guan Tan, Adriana Ortiz-Lopez, Tsering Bakto Yanortsang, Liang Yang, Ray Jupp, Diane Mathis, Christophe Benoist, Dennis L. Kasper. Mining the Human Gut Microbiota for Immunomodulatory Organisms. Cell, 2017; DOI: 10.1016/j.cell.2017.01.022

LYME and JOINTS
Monica Viladomiu, Charles Kivolowitz, Ahmed Abdulhamid, Belgin Dogan, Daniel Victorio, Jim G. Castellanos, Viola Woo, Fei Teng, Nhan L. Tran, Andrew Sczesnak, Christina Chai, Myunghoo Kim, Gretchen E. Diehl, Nadim J. Ajami, Joseph F. Petrosino, Xi K. Zhou, Sergio Schwartzman, Lisa A. Mandl, Meira Abramowitz, Vinita Jacob, Brian Bosworth, Adam Steinlauf, Ellen J. Scherl, Hsin-Jung Joyce Wu, Kenneth W. Simpson, Randy S. Longman. IgA-coated E. coli enriched in Crohn’s disease spondyloarthritis promote T H 17-dependent inflammation. Science Translational Medicine, 2017; 9 (376): eaaf9655 DOI: 10.1126/scitranslmed.aaf9655

RESEARCH
J. Firth, B. Stubbs, J. Sarris, S. Rosenbaum, S. Teasdale, M. Berk, A. R. Yung. The effects of vitamin and mineral supplementation on symptoms of schizophrenia: a systematic review and meta-analysis. Psychological Medicine, 2017; 1 DOI: 10.1017/S0033291717000022.

Min Wei, Sebastian Brandhorst, Mahshid Shelehchi, Hamed Mirzaei, Chia Wei Cheng, Julia Budniak, Susan Groshen, Wendy J. Mack, Esra Guen, Stefano Di Biase, Pinchas Cohen, Todd E. Morgan, Tanya Dorff, Kurt Hong, Andreas Michalsen, Alessandro Laviano, Valter D. Longo. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Science Translational Medicine, 2017; 9 (377): eaai8700 DOI: 10.1126/scitranslmed.aai8700.

Julia H. Kreznar, Mark P. Keller, Lindsay L. Traeger, Mary E. Rabaglia, Kathryn L. Schueler, Donald S. Stapleton, Wen Zhao, Eugenio I. Vivas, Brian S. Yandell, Aimee Teo Broman, Bruno Hagenbuch, Alan D. Attie, Federico E. Rey. Host Genotype and Gut Microbiome Modulate Insulin Secretion and Diet-Induced Metabolic Phenotypes. Cell Reports, 2017; 18 (7): 1739 DOI: 10.1016/j.celrep.2017.01.062.

Robert S. Thompson, Rachel Roller, Agnieszka Mika, Benjamin N. Greenwood, Rob Knight, Maciej Chichlowski, Brian M. Berg, Monika Fleshner. Dietary Prebiotics and Bioactive Milk Fractions Improve NREM Sleep, Enhance REM Sleep Rebound and Attenuate the Stress-Induced Decrease in Diurnal Temperature and Gut Microbial Alpha Diversity. Frontiers in Behavioral Neuroscience, 2017; 10 DOI: 10.3389/fnbeh.2016.00240.

Nina Kim, Thomas H. Thatcher, Patricia J. Sime, Richard P. Phipps. Corticosteroids inhibit anti-IgE activities of specialized proresolving mediators on B cells from asthma patients. JCI Insight, 2017; 2 (3) DOI: 10.1172/jci.insight.88588

Tiffany Zee, Neelanjan Bose, Jarcy Zee, Jennifer N Beck, See Yang, Jaspreet Parihar, Min Yang, Sruthi Damodar, David Hall, Monique N O’Leary, Arvind Ramanathan, Roy R Gerona, David W Killilea, Thomas Chi, Jay Tischfield, Amrik Sahota, Arnold Kahn, Marshall L Stoller, Pankaj Kapahi. α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria. Nature Medicine, 2017; DOI: 10.1038/nm.4280

Zhongyuan Guo, Nicole J. Martucci, Fabiola Moreno-Olivas, Elad Tako, Gretchen J. Mahler. Titanium dioxide nanoparticle ingestion alters nutrient absorption in an in vitro model of the small intestine. NanoImpact, 2017; 5: 70 DOI: 10.1016/j.impact.2017.01.002.

Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon

Sarah Bettini et al. Scientific Reports 7, Article number: 40373 (2017). doi:10.1038/srep40373.

Pete A. Williams, Jeffrey M. Harder, Nicole E. Foxworth, Kelly E. Cochran, Vivek M. Philip, Vittorio Porciatti, Oliver Smithies, Simon W. M. John. Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. Science, 2017; 355 (6326): 756 DOI: 10.1126/science.aal0092.

NEW RELEASES
An Exploratory Investigation of Endotoxin Levels in Novice Long Distance Triathletes, and the Effects of a Multi-Strain Probiotic/Prebiotic, Antioxidant Intervention

Justin D. Roberts et al. Nutrients 2016, 8(11), 733; doi:10.3390/nu8110733.

February 2017

IHCAN Feb 2017 references

NEWS

Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis.

Ciccia F, Guggino G, Rizzo A, Alessandro R, Luchetti MM, Milling S, Saieva L, Cypers H, Stampone T, Di Benedetto P, Gabrielli A, Fasano A, Elewaut D, Triolo G.

Ann Rheum Dis. 2017 Jan 9. pii: annrheumdis-2016-210000. doi: 10.1136/annrheumdis-2016-210000. [Epub ahead of print]

Ahmed Tawakol, Amorina Ishai, Richard AP Takx, Amparo L Figueroa, Abdelrahman Ali, Yannick Kaiser, Quynh A Truong, Chloe JE Solomon, Claudia Calcagno, Venkatesh Mani, Cheuk Y Tang, Willem JM Mulder, James W Murrough, Udo Hoffmann, Matthias Nahrendorf, Lisa M Shin, Zahi A Fayad, Roger K Pitman. Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study. The Lancet, 2017; DOI: 10.1016/S0140-6736(16)31714-7

J Calvin Coffey, D Peter O’Leary. The mesentery: structure, function, and role in diseaseThe Lancet Gastroenterology & Hepatology, 2016; 1 (3): 238 DOI: 10.1016/S2468-1253(16)30026-7

Heather F. Smith, William Parker, Sanet H. Kotzé, Michel Laurin. Morphological evolution of the mammalian cecum and cecal appendix. Comptes Rendus Palevol, 2017; 16 (1): 39 DOI: 10.1016/j.crpv.2016.06.001

LYME – JONATHAN OPRCHARD
Eur Spine J. 2013 Apr;22(4):697-707. doi: 10.1007/s00586-013-2675-y. Epub 2013 Feb 13. Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy.

Albert HB1, Sorensen JS, Christensen BS, Manniche C.

Br J Sports Med. 2008 Dec;42(12):969-73. doi: 10.1136/bjsm.2008.050369. Epub 2008 Aug 21. Antibiotic treatment in patients with low-back pain associated with Modic changes Type 1 (bone oedema): a pilot study.

Albert HB1, Manniche C, Sorensen JS, Deleuran BW.

Eur J Microbiol Immunol (Bp). 2015 Dec; 5(4): 268–280.

Published online 2015 Nov 12. doi:  10.1556/1886.2015.00031

Effectiveness of Stevia Rebaudiana Whole Leaf Extract Against the Various Morphological Forms of Borrelia Burgdorferi in Vitro

  1. A. S. Theophilus, M. J. Victoria, K. M. Socarras, K. R. Filush, K. Gupta, D. F. Luecke, and E. Sapi

OSTEOARTHRITIS – BEN BROWN

  1. Glyn-Jones S, et al Osteoarthritis. 2015 Mar 3. pii: S0140-6736(14)60802-3.
  2. Patrono C, Baigent C. Nonsteroidal anti-inflammatory drugs and the heart. Circulation. 2014 Feb 25;129(8):907-16.
  3. Green JA, Hirst-Jones KL, Davidson RK, et al. The potential for dietary factors to prevent or treat osteoarthritis. Proc Nutr Soc. 2014 May;73(2):278-88.
  4. Veronese N, Stubbs B, Noale M, Solmi M, Luchini C, Maggi S. Adherence to the Mediterranean diet is associated with better quality of life: data from the Osteoarthritis Initiative. Am J Clin Nutr. 2016 Nov;104(5):1403-1409.
  5. Clinton CM, et al. Whole-foods, plant-based diet alleviates the symptoms of osteoarthritis. Arthritis. 2015;2015:708152.
  6. Gudbergsen H, et al. Weight loss is effective for symptomatic relief in obese subjects with knee osteoarthritis independently of joint damage severity assessed by high-field MRI and radiography. Osteoarthritis Cartilage. 2012 Jun;20(6):495-502.
  7. Riecke BF, et al. Comparing two low-energy diets for the treatment of knee osteoarthritis symptoms in obese patients: a pragmatic randomized clinical trial. Osteoarthritis Cartilage. 2010 Jun;18(6):746-54.
  8. DeChristopher LR, Uribarri J, Tucker KL. Intake of high-fructose corn syrup sweetened soft drinks, fruit drinks and apple juice is associated with prevalent arthritis in US adults, aged 20-30 years. Nutr Diabetes. 2016 Mar 7;6:e199.
  9. Ghoochani N, Karandish M, Mowla K, Haghighizadeh MH, Jalali MT. The effect of pomegranate juice on clinical signs, matrix metalloproteinases and antioxidant status in patients with knee osteoarthritis. J Sci Food Agric. 2016 Oct;96(13):4377-81.
  10. Schumacher HR, Pullman-Mooar S, Gupta SR, Dinnella JE, Kim R, McHugh MP. Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee. Osteoarthritis Cartilage. 2013 Aug;21(8):1035-41.
  11. Hashempur MH, Sadrneshin S, Mosavat SH, Ashraf A. Green tea (Camellia sinensis) for patients with knee osteoarthritis: A randomized open-label active-controlled clinical trial. Clin Nutr. 2016 Dec 18.
  12. Rovati LC, Girolami F, Persiani S. Crystalline glucosamine sulphate in the management of knee osteoarthritis: efficacy, safety, and pharmacokinetic properties. Ther Adv Musculoskelet Dis. 2012 Jun;4(3):167-80.
  13. Reginster JY, et al. Role of glucosamine in the treatment for osteoarthritis. Rheumatol Int. 2012 Oct;32(10):2959-67.
  14. Salazar J, et al. Glucosamine for osteoarthritis: biological effects, clinical efficacy, and safety on glucose metabolism. Arthritis. 2014;2014:432463
  15. Biggee BA, Blinn CM, McAlindon TE, et al. Low levels of human serum glucosamine after ingestion of glucosamine sulphate relative to capability for peripheral effectiveness. Ann Rheum Dis. 2006 Feb;65(2):222-6.
  16. Coulson S, Butt H, Vecchio P, et al. Green-lipped mussel extract (Perna canaliculus) and glucosamine sulphate in patients with knee osteoarthritis: therapeutic efficacy and effects on gastrointestinal microbiota profiles. 2013 Feb;21(1):79-90.
  17. Henrotin Y, Marty M, Mobasheri A. What is the current status of chondroitin sulphate and glucosamine for the treatment of knee osteoarthritis? Maturitas. 2014 Jul;78(3):184-7.
  18. Singh JA, Noorbaloochi S, MacDonald R, Maxwell LJ. Chondroitin for osteoarthritis. Cochrane Database Syst Rev. 2015 Jan 28;1:CD005614.
  19. Zeng C, Wei J, Li H, Wang YL, Xie DX, Yang T, Gao SG, Li YS, Luo W, Lei GH. Effectiveness and safety of Glucosamine, chondroitin, the two in combination, or celecoxib in the treatment of osteoarthritis of the knee. Sci Rep. 2015 Nov 18;5:16827.
  20. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulphate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006 Feb 23;354(8):795-808.
  21. Usha PR, Naidu MU. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis. Clin Drug Investig. 2004;24(6):353-63.
  22. Debbi EM, et al. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011 Jun 27;11:50.
  23. Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical Osteoarthritis Cartilage. 2006 Mar;14(3):286-94.
  24. Bagchi D, et al. Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. Int J Clin Pharmacol Res. 2002;22(3-4):101-10.
  25. Crowley DC, et al. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci. 2009 Oct 9;6(6):312-21
  26. Abdel-Tawab M, et al. Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data. Clin Pharmacokinet. 2011 Jun;50(6):349-69. Doi
  27. Cameron M, Chrubasik S. Oral herbal therapies for treating osteoarthritis. Cochrane Database Syst Rev. 2014 May 22;5:CD002947.
  28. Vishal AA, Mishra A, Raychaudhuri SP. A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee. Int J Med Sci. 2011;8(7):615-22.
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MEDICAL NLP

  1. Pinker S (New Ed 1995) The Language Instinct: The New Science of Language and Mind. London: Penguin Books Ltd

2 House JS, Landis KR, Umberson D (1988) Social relations and health.  Science  241:  540–5; Hafen Q, Karren KJ, Frandsen KJ, Smith NL (1996)  Mind/Body Health: The Effects of Attitudes, Emotions and Relationships , Boston: Allyn & Bacon; The GUSTO Investigators (1993) An international randomized trial comparing four thrombolytic studies for acute myocardial infarction.  New England Journal of Medicine 329: 673–82.

3 Witthöft M, Rubin GJ (2013), Are media warnings about the adverse health effects of modern life self-fulfilling? An experimental study on idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF) Journal of Psychosomatic Research

4 Osmo A. Wiio (1978). Wiion lait – ja vähän muidenkin (Wiio’s laws – and some others). Weilin+Göös.

5 Sigmund Freud  The Standard Edition of the Complete Psychological Works of Sigmund Freud, translated and edited by James Strachey.  The Institute of Psycho-Analysis and The Hogarth Press

6 Freud S (Paperback ed. 1991) Introductory Lectures (1916-17). London:Penguin Books Ltd

7 Rosencranz MA et al (2005) Neural circuitry underlying the interaction between emotion and asthma symptom exacerbation. PNAS 102 (37): 13319–24.

8 Langer E, Dillon M, Kurtz R, and Katz M (1998) Believing is Seeing, Harvard University, Department of Psychology.

9 Coversation with author

10 Olde Hartman TC, Lucassen PL, van de Lisdonk EH et al (2004) Chronic functional somatic symptoms: a single syndrome? British Journal of General Practice 54: 922–7.
11 See Dr Bandler’s introduction to the 1st edition of Magic in Practice

BLOATING – PATRICK HOLFORD

  1. Holford & Associates Ltd. 100% Digestive Health Survey, awaiting publication in February.
  2. Zar, S., et al. Food-specific serum IgG4 and IgE titers to common food antigens in irritable bowel syndrome. Am J Gastroenterol.. 2005 Jul; 100(7):1550–7; see also Zuo X.L., et al. Alterations of food antigen-specific serum immunoglobulins G and E antibodies in patients with irritable bowel syndrome and functional dyspepsia. Clin Exp Allergy. 2007 Jun; 37(6):823-30.
  3. Finn R., et al. Immunological hypersensitivity to environmental antigens in the irritable bowel syndrome. Br J Clin Pract. 1987 Dec; 41(12):1041-3.
  4. Zar, S., et al. Food-specific serum IgG4 and IgE titers to common food antigens in irritable bowel syndrome. Am J Gastroenterol.. 2005 Jul; 100(7):1550–7.
  5. Atkinson, W., et al. Food elimination based on IgG antibodies in irritable bowel syndrome: A randomised controlled trial. Gut. 2004 Oct; 53(10):1459–64
  6. van Gils, T., et al. Prevalence and characterization of self-reported gluten

sensitivity in the Netherlands. Nutrients. 2016 Nov; 8(11):714.

  1. Zanwar, V.G., et al. Symptomatic improvement with gluten restriction in irritable bowel syndrome: a prospective, randomized, double blinded placebo controlled

trial. Intestinal Research. 2016 Oct; 14(4):343–350.

  1. Sofi, F., et al. Effect of Triticum turgidum subsp. turanicum wheat on irritable bowel syndrome: a double-blinded randomised dietary intervention trial. Br J Nutr. 2014 Jun; 111(1):1992–9.
  2. Maagaard L., et al. Follow- up of patients with functional bowel

symptoms treated with a low FODMAP diet. World J Gastroenterol. 2016

Apr; 22(15):4009–19.

  1. Eswaran, S.L., et al. A randomised controlled trial comparing the low FODMAP diet vs. modified NICE guidelines in US adults with IBS-D. Am J Gastroenterol. 2016 Dec; 111(12):1824-1832.
  2. Iranio, G. Digestive enzyme supplementation in gastrointestinal diseases. Curr Drug Metab. 2016 Feb; 17(2):187–193.
  3. Moayyedi, P., et al. The efficacy of probiotics in the treatment of

irritable bowel syndrome: A systematic review. Gut. 2010 Mar; 59(3):325–32.

  1. Silk, D.B., et al. Clinical trial: The effects of a transgalactooligosaccharide

prebiotic on faecal microbiota and symptoms in irritable bowel syndrome. Aliment Pharmacology and Therapeutics. 2009 Mar; 29(5):508–18.

  1. Jalanka- Tuovinen, J., et al. Intestinal microbiota in healthy adults:

Temporal analysis reveals individual and common core and relation to intestinal symptoms. PLoS One, 2011 Jul; 6(7):e23035.

  1. 1 Baştür, A., et al. Efficacy of synbiotic, probiotic, and prebiotic treatments for

irritable bowel syndrome in children: A randomized controlled

trial. Turk J Gastroenterol. 2016 Sep; 27(5):439-443.

LEARNING ZONE – LYME

  1. PHE/RIPL website: https://www.gov.uk/government/collections/rare-and-imported-pathogens-laboratory-ripl
    2. Stevenson B. Variable VlsE Is Critical for Host Reinfection by the Lyme Disease Spirochete. PLoS One. 2013, 8(4)
    3. Meriläinen L et al. Morphological and biochemical features of Borrelia burgdorferi pleomorphic forms. Microbiology. 2015 Mar;161(Pt 3):516-27.
    4. Sapi E et al. Characterization of Biofilm Formation by Borrelia burgdorferi In Vitro. PLoS One. 2013 7(10)
    5. Cook MJ and Puri BP. Commercial test kits for detection of Lyme borreliosis: a meta-analysis of test accuracy. Int J Gen Med. 2016, Nov 18;9:427-440
    6. Stricker RB et al. Lyme disease: the promise of Big Data, companion diagnostics and precision medicine. Infect Drug Resist. 2016;9:215-219
    7. Lehman PV et al. Unique Strengths of ELISPOT for T Cell Diagnostics. In: Kalyuzhny AE. Handbook of ELISPOT: Methods and Protocols, Methods in Molecular Biology, Vol. 792. 2nd Ed: Springer; 2012: 3-23.
    8. Stricker RB and Winger EE. Decreased CD57 Lymphocyte Subset in Patients with Chronic Lyme Disease. Immunology Letters, 2001;76, 43-48.

LEARNING ZONE – the Sensitivity Gene

* The January 2015 Duke University study, “Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial,” was published in the Journal of Policy Analysis and Management.
*Benedicte Meyer et al, Maintenance of Chronic Fatigue Syndrome (CFS) in Young CFS Patients Is Associated with the 5-HTTLPR and SNP rs25531 A > G Genotype. PLOS One,  2015, https://dx.doi.org/10.1371/journal.pone.0140883

* Felitti VJ, Anda RF et al. Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults: The Adverse Childhood Experiences (ACE) Study. Am J Preventive Med May 1998, 14, 4,: 245–58.

* For The Sensitivity Hypothesis, Dandelion and Orchid Children, see research by Bruce Ellis  University of Arizona, and W Thomas Boyce  University of British Columbia, for example “Biological sensitivity to context: I. An evolutionary–developmental theory of the origins and functions of stress reactivity” in Development and Psychopathology

17, 2005, 271–301. DOI: 10.1017/S095457940505014.

* Childhood Disrupted: How Your Biography Becomes Your Biology and How You Can Heal, by Donna Jackson Nakazawa: https://donnajacksonnakazawa.com/childhood-disrupted/.

* GSC – Genetically Sensitive Client- Chrysalis Effect Specialist Practitioner Training Elaine Wilkins: https://www.thechrysaliseffectpractitioners.com/.

RESEARCH

Isabel Garcia-Perez, Joram M Posma, Rachel Gibson, Edward S Chambers, Tue H Hansen, Henrik Vestergaard, Torben Hansen, Manfred Beckmann, Oluf Pedersen, Paul Elliott, Jeremiah Stamler, Jeremy K Nicholson, John Draper, John C Mathers, Elaine Holmes, Gary Frost. Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial. The Lancet Diabetes & Endocrinology, 2017; DOI: 10.1016/S2213-8587(16)30419-3

A Meta-Analysis of Randomized Controlled Trials and Prospective Cohort Studies of Eicosapentaenoic and Docosahexaenoic Long-Chain Omega-3 Fatty Acids and Coronary Heart Disease Risk. Dominik D. Alexander et al. Open Access . DOI: https://dx.doi.org/10.1016/j.mayocp.2016.10.018

Mayo Clinic Proceedings, January 2017, Volume 92, Issue 1, Pages 15–29.

January 2017

NEWS
Arch Intern Med. 1999 Sep 27;159(17):1981-7.). Homeopathy re-revisited: is homeopathy compatible with biomedical observations? Eskinazi D.

Saha, SK. et al. Ultrahighly diluted plant extracts of Hydrastis canadensis and Marsdenia condurango induce epigenetic modifications and alter gene expression profiles in HeLa cells in vitroJ. Integr. Med13, 400–411 (2015).

Randomised placebo-controlled trials of individualised homeopathic treatment: systematic review and meta-analysis. Robert T Mathie et al. Systematic Rev, 2014, 3:142. DOI: 10.1186/2046-4053-3-142.

Cell, Ocampo et al.: “In vivo amelioration of age-associated hallmarks by partial reprogramming.” DOI: 10.1016/j.cell.2016.11.052 , www.cell.com/cell/fulltext/S0092-8674(16)31664-6

NEW RELEASES

Diabetes Res Clin Pract. 2009 Feb;83(2):e40-2. doi: 10.1016/j.diabres.2008.11.014. Epub 2008 Dec 23. Immediate and long-term effects of glucomannan on total ghrelin and leptin in type 2 diabetes mellitus. Chearskul S1, Kriengsinyos W, Kooptiwut S, Sangurai S, Onreabroi S, Churintaraphan M, Semprasert N, Nitiyanant W.

BEN BROWN

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Additional story:
Antonio Gonzalez, Embriette Hyde, Naseer Sangwan, Jack A. Gilbert, Erik Viirre, Rob Knight. Migraines Are Correlated with Higher Levels of Nitrate-, Nitrite-, and Nitric Oxide-Reducing Oral Microbes in the American Gut Project Cohort. mSystems, October 2016 DOI: 10.1128/mSystems.00105-16
NUTRIGENETICS

Nutritional approaches to combat oxidative stress in Alzheimer’s disease. Butterfield D, Castegna A, Pocernich C, Drake J, Scapagnini G, Calabrese V. J Nutr Biochem. 2002 Aug;13(8):444.

Influence of apple polyphenols on inflammatory gene expression. Jung M, Triebel S, Anke T, Richling E, Erkel G. Mol Nutr Food Res. 2009 Oct;53(10):1263-80. doi: 10.1002/mnfr.200800575.

Christopher T. Ford, Siân Richardson, Francis McArdle, Silvina B. Lotito, Alan Crozier, Anne McArdle, Malcolm J. Jackson. Identification of (poly)phenol treatments that modulate the release of pro-inflammatory cytokines by human lymphocytes. British Journal of Nutrition, 2016; 115 (10): 1699 DOI: 10.1017/S0007114516000805

  1. Zamora-Ros, M. Rabassa, A. Cherubini, M. Urpi-Sarda, S. Bandinelli, L. Ferrucci, C. Andres-Lacueva. High Concentrations of a Urinary Biomarker of Polyphenol Intake Are Associated with Decreased Mortality in Older Adults. Journal of Nutrition, 2013; 143 (9): 1445 DOI: 10.3945/jn.113.177121

Harri Hemil. Vitamin E and the risk of pneumonia: using the I²-statistic to quantify heterogeneity within a controlled trial. British Journal of Nutrition, 2016; 1 DOI: 10.1017/S0007114516003408.

Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 – Fields of Precision Nutrition

J Nutrigenet Nutrigenomics 2016;9:12-27, (DOI:10.1159/000445350)

Fulltext PDF (674 Kb) Free Access at www.karger.com/Article/FullText/445350

GUT

From Sample to Multi-Omics Conclusions in under 48 Hours. Robert A. Quinn, Jose A. Navas-Molina, Embriette R. Hyde, Se Jin Song, Yoshiki Vázquez-Baeza, Greg Humphrey, James Gaffney, Jeremiah J. Minich, Alexey V. Melnik, Jakob Herschend, Jeff DeReus, Austin Durant, Rachel J. Dutton, Mahdieh Khosroheidari, Clifford Green, Ricardo da Silva, Pieter C. Dorrestein, Rob Knight

Jack A. Gilbert, Editor. mSystems, 2016: DOI: 10.1128/mSystems.00038-16.

Timothy R. Sampson et al. Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease. Cell, December 2016 DOI: 10.1016/j.cell.2016.11.018.

Christoph A. Thaiss et al. Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations. Cell, December 2016 DOI: 10.1016/j.cell.2016.11.003

Diet-Microbiome Interactions in Health Are Controlled by Intestinal Nitrogen Source Constraints. Andrew J. Holmes et al. Cell Metabolism. In Press. available online 23 November 2016.

RESEARCH
Francesco Foroni, Giulio Pergola, Raffaella Ida Rumiati. Food colour is in the eye of the beholder: the role of human trichromatic vision in food evaluation. Scientific Reports, 2016; 6: 37034 DOI: 10.1038/srep37034

Dagfinn Aune, NaNa Keum, Edward Giovannucci, Lars T. Fadnes, Paolo Boffetta, Darren C. Greenwood, Serena Tonstad, Lars J. Vatten, Elio Riboli, Teresa Norat. Nut consumption and risk of cardiovascular disease, total cancer, all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective studies. BMC Medicine, 2016; 14 (1) DOI: 10.1186/s12916-016-0730-3

  1. Zelano, H. Jiang, G. Zhou, N. Arora, S. Schuele, J. Rosenow, J. A. Gottfried. Nasal Respiration Entrains Human Limbic Oscillations and Modulates Cognitive Function. Journal of Neuroscience, 2016; 36 (49): 12448 DOI: 10.1523/JNEUROSCI.2586-16.2016

* Video: https://www.youtube.com/watch?v=1KNn0NYjMWg.

Candyce H. Kroenke, Yvonne L. Michael, Elizabeth M. Poole, Marilyn L. Kwan, Sarah Nechuta, Eric Leas, Bette J. Caan, John Pierce, Xiao-Ou Shu, Ying Zheng, Wendy Y. Chen. Postdiagnosis social networks and breast cancer mortality in the After Breast Cancer Pooling Project. Cancer, 2016; DOI: 10.1002/cncr.30440.

  1. Gunness, J. Michiels, L. Vanhaecke, S. De Smet, O. Kravchuk, A. Van de Meene, M. J. Gidley. Reduction in circulating bile acid and restricted diffusion across the intestinal epithelium are associated with a decrease in blood cholesterol in the presence of oat  -glucan. The FASEB Journal, 2016; 30 (12): 4227 DOI: 10.1096/fj.201600465R.

Inmaculada Moreno, Francisco M. Codoñer, Felipe Vilella, Diana Valbuena, Juan F. Martinez-Blanch, Jorge Jimenez-Almazán, Roberto Alonso, Pilar Alamá, Jose Remohí, Antonio Pellicer, Daniel Ramon, Carlos Simon. Evidence that the endometrial microbiota has an effect on implantation success or failure. American Journal of Obstetrics and Gynecology, 2016; 215 (6): 684 DOI: 10.1016/j.ajog.2016.09.075

Haiqiu Huang, Xiaojing Jiang, Zhenlei Xiao, Lu Yu, Quynhchi Pham, Jianghao Sun, Pei Chen, Wallace Yokoyama, Liangli Lucy Yu, Yaguang Sunny Luo, Thomas T. Y. Wang. Red Cabbage Microgreens Lower Circulating Low-Density Lipoprotein (LDL), Liver Cholesterol, and Inflammatory Cytokines in Mice Fed a High-Fat Diet. Journal of Agricultural and Food Chemistry, 2016; 64 (48): 9161 DOI: 10.1021/acs.jafc.6b03805

December 2016

NEWS

Giannis Koukkidis, Richard Haigh, Natalie Allcock, Suzanne Jordan, and Primrose Freestone. Salad leaf juices enhance Salmonella growth, fresh produce colonisation and virulence. Applied and Environmental Microbiology, November 2016 DOI: 10.1128/AEM.02416-16
Cheng-Shiuan Lee, Molly E. Lutcavage, Emily Chandler, Daniel J. Madigan, Robert M. Cerrato, Nicholas S. Fisher. Declining Mercury Concentrations in Bluefin Tuna Reflect Reduced Emissions to the North Atlantic Ocean. Environmental Science & Technology, 2016; DOI: 10.1021/acs.est.6b04328

Lei Yin, Kevin Yu, Simon Lin, Xiao Song, Xiaozhong Yu. Associations of blood mercury, inorganic mercury, methyl mercury and bisphenol A with dental surface restorations in the U.S. population, NHANES 2003–2004 and 2010–2012. Ecotoxicology and Environmental Safety, 2016; 134: 213 DOI: 10.1016/j.ecoenv.2016.09.001

Dr Mark Hyman on mercury:
https://drhyman.com/blog/2010/05/20/mercury-get-this-poison-out-of-your-body.

NEWS EXTRA

Elmira Akbari, Zatollah Asemi, Reza Daneshvar Kakhaki, Fereshteh Bahmani, Ebrahim Kouchaki, Omid Reza Tamtaji, Gholam Ali Hamidi, Mahmoud Salami. Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer’s Disease: A Randomized, Double-Blind and Controlled Trial. Frontiers in Aging Neuroscience, 2016; 8 DOI: 10.3389/fnagi.2016.00256

BEN BROWN Migraine

1. Younger DS. Epidemiology of Migraine. Neurol Clin. 2016 Nov;34(4):849-861.

  1. Natoli JL, Manack A, Dean B, Butler Q, Turket CC, Stovner L, et al. Global prevalence of chronic migraine: a systematic review. Cephalalgia. 2010;30:599–609.

3. Lipton RB, Bigal ME, Diamond M, Freitag F, Reed ML, Stewart WF; AMPP Advisory  Group.. Migraine prevalence, disease burden, and the need for preventive therapy. Neurology. 2007 Jan 30;68(5):343-9.4. Bigal M, Krymchantowski AV, Lipton RB. Barriers to satisfactory migraine outcomes. What have we learned, where do we stand? Headache. 2009 Jul;49(7):1028-41.5. Sun-Edelstein C, Rapoport AM. Update on the Pharmacological Treatment of Chronic Migraine. Curr Pain Headache Rep. 2016 Jan;20(1):6.6. Peck KR, Johnson YL, Smitherman TA. Migraine. Handb Clin Neurol. 2016;138:283-93. 7. Carod-Artal FJ. Tackling chronic migraine: current perspectives. J Pain Res. 2014 Apr 8;7:185-94.8. May A, Schulte LH. Chronic migraine: risk factors, mechanisms and treatment. Nat Rev Neurol. 2016 Aug;12(8):455-64.9. Buture A, Gooriah R, Nimeri R, Ahmed F. Current Understanding on Pain Mechanism in Migraine and Cluster Headache. Anesth Pain Med. 2016 Apr10.                           23;6(3):e35190.11.                           Dalkara T, Zervas NT, Moskowitz MA. From spreading depression to the trigeminovascular system. Neurol Sci. 2006 May;27 Suppl 2:S86-90.12.                           Sheeler RD, Garza I, Vargas BB, O’Neil AE. Chronic Daily Headache: Ten Steps for Primary Care Providers to Regain Control. Headache. 2016 Aug 23. doi: 10.1111/head.12881. [Epub ahead of print]

  1. Sun-Edelstein C, Mauskop A. Alternative headache treatments: nutraceuticals, behavioral and physical treatments. Headache. 2011;51:469–83

14.                           Sun-Edelstein C, Mauskop A. Foods and supplements in the management of migraine headaches. Clin J Pain. 2009 Jun;25(5):446-52. 15.                           Cámara-Lemarroy CR, Rodriguez-Gutierrez R, Monreal-Robles R, Marfil-Rivera A.  Gastrointestinal disorders associated with migraine: A comprehensive review. World J Gastroenterol. 2016 Sep 28;22(36):8149-60.

  1. Gasbarrini A, Gabrielli M, Fiore G, Candelli M, Bartolozzi F, De Luca A, Cremonini F, Franceschi F, Di Campli C, Armuzzi A, et al. Association between Helicobacter pylori cytotoxic type I CagA-positive strains and migraine with aura. 2000;20:561–565.
  2. Tunca A, Türkay C, Tekin O, Kargili A, Erbayrak M. Is Helicobacter pylori infection a risk factor for migraine? A case-control study.Acta Neurol Belg. 2004;104:161–164.
  3. Faraji F, Zarinfar N, Zanjani AT, Morteza A. The effect of Helicobacter pylori eradication on migraine: a randomized, double blind, controlled trial.Pain Physician. 2012;15:495–498
  4. Aydinlar EI, Dikmen PY, Tiftikci A, Saruc M, Aksu M, Gunsoy HG, Tozun N. IgG-based elimination diet in migraine plus irritable bowel syndrome. 2013;53:514–525
  5. Gabrielli M, Cremonini F, Fiore G, Addolorato G, Padalino C, Candelli M, De Leo ME, Santarelli L, Giacovazzo M, Gasbarrini A, et al. Association between migraine and Celiac disease: results from a preliminary case-control and therapeutic study.Am J Gastroenterol. 2003;98:625–629

21.                           Sensenig J, Johnson M, Staverosky T. Treatment of migraine with targeted nutrition focused on improved assimilation and elimination. Altern Med Rev. 2001  Oct;6(5):488-94.

  1. Gonzalez A, Hyde E, Sangwan N, Gilbert JA, Viirre E, Knight R. 2016.Migraines are correlated with higher levels of nitrate-, nitrite-, and nitric oxide-reducing oral microbes in the American Gut Project Cohort. mSystems 1(5):e00105-16.

23.                           de Roos NM, Giezenaar CG, Rovers JM, Witteman BJ, Smits MG, van Hemert S. The  effects of the multispecies probiotic mixture Ecologic®Barrier on migraine: results of an open-label pilot study. Benef Microbes. 2015;6(5):641-6.24.                           Malhotra R. Understanding migraine: Potential role of neurogenic inflammation. Ann Indian Acad Neurol. 2016 Apr-Jun;19(2):175-82.25.                           Lippi G, Mattiuzzi C, Cervellin G. C-reactive protein and migraine. Facts or speculations? Clin Chem Lab Med. 2014 Sep;52(9):1265-72.

  1. Theodoropoulos DS, Katzenberger DR, Jones WM, Morris DL, Her C, Cullen NA, et al. Allergen-specific sublingual immunotherapy in the treatment of migraines: a prospective study. Eur Rev Med Pharmacol Sci 2011;15:1117–21
  2. Meng WG, Shi L, Wu LY, Lai LY, Song RX, Huang SZ. Clinical research on treatment of migraine with pine needle moxibustion. Zhongguo Zhen Jiu 2012;32:519–22.

28.                           Maghbooli M, Golipour F, Moghimi Esfandabadi A, Yousefi M. Comparison between  the efficacy of ginger and sumatriptan in the ablative treatment of the common migraine. Phytother Res. 2014 Mar;28(3):412-5

  1. Liberopoulos EN, Mikhailidis DP. Could statins be useful in the treatment of patients with migraine? Headache 2006;46:672–5
  2. Medeiros FL, Medeiros PL, Valença MM, Dodick D. Simvastatin for migraine prevention. Headache 2007;47:855–6.

31.                           Marmura MJ, Silberstein SD, Schwedt TJ. The acute treatment of migraine in adults: the american headache society evidence assessment of migraine pharmacotherapies. Headache. 2015 Jan;55(1):3-20.

  1. Bond DS, Roth J, Nash JM, Wing RR. Migraine and obesity: epidemiology, possible mechanisms and the potential role of weight loss treatment.Obes Rev. 2011;12:e362–71.
  2. Verrotti A, Agostinelli S, D’Egidio C, Di Fonzo A, Carotenuto M, Parisi P, Esposito M, Tozzi E, Belcastro V, Mohn A, Battistella PA. Impact of a weight loss program on migraine in obese adolescents. Eur J Neurol. 2013 Feb;20(2):394-7

34.                           Yorns WR Jr, Hardison HH. Mitochondrial dysfunction in migraine. Semin Pediatr Neurol. 2013 Sep;20(3):188-93.35.                           Di Lorenzo C, Pierelli F, Coppola G, Grieco GS, Rengo C, Ciccolella M, Magis D, Bolla M, Casali C, Santorelli FM, Schoenen J. Mitochondrial DNA haplogroups influence the therapeutic response to riboflavin in migraineurs. Neurology. 2009  May 5;72(18):1588-94.36.                           Cordero MD, Cano-García FJ, Alcocer-Gómez E, De Miguel M, Sánchez-Alcázar JA. Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q₁₀  effect on clinical improvement. PLoS One. 2012;7(4):e35677. 37.                           Borkum JM. Migraine Triggers and Oxidative Stress: A Narrative Review and Synthesis. Headache. 2016 Jan;56(1):12-35. 38.                           Neri M, Frustaci A, Milic M, Valdiglesias V, Fini M, Bonassi S, Barbanti P. A  meta-analysis of biomarkers related to oxidative stress and nitric oxide pathway  in migraine. Cephalalgia. 2015 Sep;35(10):931-7.39.                           Ciancarelli I, Tozzi-Ciancarelli MG, Spacca G, Di Massimo C, Carolei A. Relationship between biofeedback and oxidative stress in patients with chronic migraine. Cephalalgia. 2007 Oct;27(10):1136-41.40.                           Gonullu H, Gonullu E, Karadas S, Arslan M, Kalemci O, Aycan A, Sayin R, Demir  H. The levels of trace elements and heavy metals in patients with acute migraine  headache. J Pak Med Assoc. 2015 Jul;65(7):694-7.41.                           Chen CC, Tsai SS, Yang CY. Association between Fine Particulate Air Pollution  and Daily Clinic Visits for Migraine in a Subtropical City: Taipei, Taiwan. Int J Environ Res Public Health. 2015 Apr 29;12(5):4697-708.42.                           Szyszkowicz M, Rowe BH, Kaplan GG. Ambient sulphur dioxide exposure and emergency department visits for migraine in Vancouver, Canada. Int J Occup Med Environ Health. 2009;22(1):7-12.43.                           Miller CS. The compelling anomaly of chemical intolerance. Ann N Y Acad Sci. 2001 Mar;933:1-23.44.                           Katerndahl DA, Bell IR, Palmer RF, Miller CS. Chemical intolerance in primary  care settings: prevalence, comorbidity, and outcomes. Ann Fam Med. 2012 Jul-Aug;10(4):357-65. 45.                           Genuis SJ. Toxic causes of mental illness are overlooked. Neurotoxicology. 2008 Nov;29(6):1147-9.

 

ADAPTOGENS/STRESS

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  12. Kyrou I, Tsigos C. Stress mechanisms and metabolic complications. Horm Metab Res. 2007;39(6):430-8.
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  14. Kyrou I, Tsigos C. Chronic stress, visceral obesity and gonadal dysfunction. Hormones (Athens). 2008;7(4):287-93.
  15. Azuma K, Adachi Y, Hayashi H, et al. Chronic psychological stress as a risk factor of osteoporosis. J uoeh. 2015;37(4):245-53.
  16. Singh N, Bhalla M, de Jager P, et al. An overview on ashwagandha: a rasayana (rejuvenator) of Ayurveda. Afr J Tradit Complement Altern Med. 2011;8(5 Suppl):208-13.
  17. Choudhary B, Shetty A, Langade DG. Efficacy of ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults. Ayu. 2015;36(1):63-8.
  18. Zhang ZH, Feng SH, Hu GD, et al. Effect of Rhodiola kirilowii (Regel.) Maxim on preventing high altitude reactions. A comparison of cardiopulmonary function in villagers at various altitudes. Zhongguo Zhong Yao Za Zhi. 1989;14(11):687-90, 704.
  19. Wankhede S, Langade D, Joshi K, et al. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. J Int Soc Sports Nutr. 2015;12:43.
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  21. Raghav S, Singh H, Dalal PK, et al. Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment. Indian J Psychiatry. 2006;48(4):238-42.
  22. Dhanasekaran M, Tharakan B, Holcomb LA, et al. Neuroprotective mechanisms of ayurvedic antidementia botanical Bacopa monniera. Phytother Res. 2007;21(10):965-9.
  23. Chowdhuri DK, Parmar D, Kakkar P, et al. Antistress effects of bacosides of Bacopa monnieri: modulation of Hsp70 expression, superoxide dismutase and cytochrome P450 activity in rat brain. Phytother Res. 2002;16(7):639-45.
  24. Benson S, Downey LA, Stough C, et al. An acute, double-blind, placebo-controlled cross-over study of 320 mg and 640 mg doses of Bacopa monnieri (CDRI 08) on multitasking stress reactivity and mood. Phytother Res. 2014;28(4):551-9.
  25. Zhu JS, Halpern GM, Jones K. The scientific rediscovery of an ancient Chinese herbal medicine: cordyceps sinensis: part I. J Altern Complement Med. 1998;4(3):289-303.
  26. Li SP, Li P, Dong TT, et al. Anti-oxidation activity of different types of natural cordyceps sinensis and cultured cordyceps mycelia. Phytomedicine. 2001;8(3):207-12.
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EXTRAS

E. F. G. Naninck, J. E. Oosterink, K.-Y. Yam, L. P. de Vries, H. Schierbeek, J. B. van Goudoever, R.-N. Verkaik-Schakel, J. A. Plantinga, T. Plosch, P. J. Lucassen, A. Korosi. Early micronutrient supplementation protects against early stress-induced cognitive impairments. The FASEB Journal, 2016; DOI: 10.1096/fj.201600834R

Sarkar et al. Psychobiotics and the Manipulation of Bacteria-Brain Signals. Trends in Neurosciences, October 2016 DOI: 10.1016/j.tins.2016.09.002

RESEARCH

PLoS One. 2016 Oct 31;11(10):e0165378. doi: 10.1371/journal.pone.0165378. eCollection 2016. Third Exposure to a Reduced Carbohydrate Meal Lowers Evening Postprandial Insulin and GIP Responses and HOMA-IR Estimate of Insulin Resistance. Lin PJ1, Borer KT1.

Giles Major et al. Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-related Symptoms in Individuals with Irritable Bowel Syndrome, Gastroenterology (2016). DOI: 10.1053/j.gastro.2016.09.062

  1. Pegorie, D.W. Denning, W. Welfare. Estimating the burden of invasive and serious fungal disease in the United Kingdom. Journal of Infection, 2016; DOI: 10.1016/j.jinf.2016.10.005
  1. Ren, C. Luo, Y. Feng, X. Yao, Z. Shi, F. Liang, J. X. Kang, J.-B. Wan, Z. Pei, H. Su. Omega-3 polyunsaturated fatty acids promote amyloid-  clearance from the brain through mediating the function of the glymphatic system. The FASEB Journal, 2016; DOI: 10.1096/fj.201600896
  2. Yuan, G. Wei, Y. You, Y. Huang, H. J. Lee, M. Dong, J. Lin, T. Hu, H. Zhang, C. Zhang, H. Zhou, R. Ye, X. Qi, B. Zhai, W. Huang, S. Liu, W. Xie, Q. Liu, X. Liu, C. Cui, D. Li, J. Zhan, J. Cheng, Z. Yuan, W. Jin. Rutin ameliorates obesity through brown fat activation. The FASEB Journal, 2016; DOI: 10.1096/fj.201600459RR

Harri Hemil�. Vitamin E and the risk of pneumonia: using the I²-statistic to quantify heterogeneity within a controlled trial. British Journal of Nutrition, 2016; 1 DOI: 10.1017/S0007114516003408.

November 2016

NEWS

Mi-Sung Kim, Sarah A. Krawczyk, Ludivine Doridot, Alan J. Fowler, Jennifer X. Wang, Sunia A. Trauger, Hye-Lim Noh, Hee Joon Kang, John K. Meissen, Matthew Blatnik, Jason K. Kim, Michelle Lai, Mark A. Herman. ChREBP regulates fructose-induced glucose production independently of insulin signaling. Journal of Clinical Investigation, 2016; DOI: 10.1172/JCI81993

Zaidi et al. Vitamin D Deficiency in Medical Inpatients: A Retrospective Study of Implications of Untreated Versus Treated Deficiency. Nutrition and Metabolic Insights 2016:9 65–69 doi:10.4137/NMI.S33747.

Ryan Hutchinson, Abdulhadi Akhtar, Justin Haridas, Deepa Bhat, Claus Roehrborn, Yair Lotan. Testing and referral patterns in the years surrounding the US Preventive Services Task Force recommendation against prostate-specific antigen screening. Cancer, 2016; DOI: 10.1002/cncr.30330

Agatha A. van der Klaauw, Julia M. Keogh, Elana Henning, Cheryl Stephenson, Sarah Kelway, Victoria M. Trowse, Naresh Subramanian, Stephen O’Rahilly, Paul C. Fletcher, I. Sadaf Farooqi. Divergent effects of central melanocortin signalling on fat and sucrose preference in humans. Nature Communications, 2016; 7: 13055 DOI: 10.1038/NCOMMS13055

* theguardian.com/society/2016/oct/19/doctors-know-too-little-about-effects-of-nutrition-and-exercise. Denis Campbell10/20/2016.

BEN BROWN

  1. Prasad S, Gupta SC, Tyagi AK, et al. Curcumin, a component of golden spice: from bedside to bench and back. Biotechnol Adv. 2014 Nov 1;32(6):1053-64.
  2. September, 2016. https://www.nutraingredients-usa.com/Markets/Turmeric-leads-the-charge-as-herbal-sales-continue-to-bloom
  3. Li, S. Y., Yuan, W., Deng, G. R., Wang, P. et al., Chemical composition and product quality control of turmeric (Curcuma longa L.). Pharmaceutical Crops 2011, 2, 28–54.

4.             Kou MC, Chiou SY, Weng CY, Wang L, Ho CT, Wu MJ. Curcuminoids distinctly exhibit antioxidant activities and regulate expression of scavenger receptors and heme oxygenase-1. Mol Nutr Food Res. 2013 Sep;57(9):1598-610.

  1. Kiuchi, F.; Goto, Y.; Sugimoto, N.; Akao, N.; Kondo, K.; Tsuda, Y. Nematocidal activity of turmeric: Synergistic action of curuminoids.  Pharm. Bull.1993, 41, 1640–1643

6.             Guo LY, Cai XF, Lee JJ, Kang SS, Shin EM, Zhou HY, Jung JW, Kim YS. Comparison of suppressive effects of demethoxycurcumin and bisdemethoxycurcumin on expressions of inflammatory mediators in vitro and in vivo. Arch Pharm Res. 2008  Apr;31(4):490-6.

  1. Aggarwal BB, Yuan W, Li S, Gupta SC. Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric. Mol Nutr Food Res. 2013 Sep;57(9):1529-42.

8.             Madhu K, Chanda K, Saji MJ. Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial. Inflammopharmacology. 2013 Apr;21(2):129-36.9.             Metzler M, Pfeiffer E, Schulz SI, Dempe JS. Curcumin uptake and metabolism. Biofactors. 2013 Jan-Feb;39(1):14-20.10.         Wang K, Qiu F. Curcuminoid metabolism and its contribution to the pharmacological effects. Curr Drug Metab. 2013 Sep;14(7):791-806.

  1. Shen L, Liu CC, An CY, Ji HF. How does curcumin work with poor bioavailability? Clues from experimental and theoretical studies. Sci Rep. 2016 Feb 18;6:20872.
  2. Jäger R, Lowery RP, Calvanese A, Joy JM, Purpura M, Wilson JM. Comparative absorption of curcumin formulations. Nutr J. 2014;13:1–8

13.         Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6.

  1. Al-Karawi D, Al Mamoori DA, Tayyar Y. The Role of Curcumin Administration in Patients with Major Depressive Disorder: Mini Meta-Analysis of Clinical Trials.Phytother Res. 2016 Feb;30(2):175-83.
  2. Chassaing B, et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 2015 Mar 5;519(7541):92-6
  3. Ng TP, Chiam PC, Lee T, Chua HC, Lim L, Kua EH. Curry consumption and cognitive function in the elderly. Am J Epidemiol. 2006;164:898–906

17.         Hanai H, Iida T, Takeuchi K, et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. 2006 Dec;4(12):1502-6.18.         Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, et al. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014 Mar 20;9:451-819.         Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. 2012 Nov;35(11):2121-7. doi: 10.2337/dc12-0116.

  1. Curcumin attenuates severity of premenstrual syndrome symptoms: A randomized, double-blind, placebo-controlled trial

21.         Hishikawa N, Takahashi Y, Amakusa Y, Tanno Y, Tuji Y, Niwa H, Murakami N, Krishna UK. Effects of turmeric on Alzheimer’s disease with behavioral and psychological symptoms of dementia. Ayu. 2012 Oct;33(4):499-504.

 

MIKE ASH

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[13] Rook GA, Brunet LR.  Microbes, immunoregulation, and the gut. Gut. 2005 Mar;54(3):317-20. Review. View Full Paper

[14] Pohjavuori E, Viljanen M, Korpela R, Kuitunen M, Tiittanen M, Vaarala O, Savilahti E. Lactobacillus GG effect in increasing IFN-gamma production in infants with cow’s milk allergy. J Allergy Clin Immunol. 2004 Jul;114(1):131-6. View Abstract

[15] Favre, L., Spertini, F. & Corthesy, B. Secretory IgA possesses intrinsic modulatory properties stimulating mucosal and systemic immune responses. J. Immunol. 175, 2793–2800 (2005). View Abstract

[16] Nose K, Yang H, Sun X, Nose S, Koga H, Feng Y, Miyasaka E, Teitelbaum DH. Glutamine prevents total parenteral nutrition-associated changes to intraepithelial lymphocyte phenotype and function: a potential mechanism for the preservation of epithelial barrier function. J Interferon Cytokine Res. 2010 Feb;30(2):67-80. View Abstract

[17] Playford RJ, Woodman AC, Clark P, Watanapa P, Vesey D, Deprez PH, Williamson RC, Calam J.

Effect of luminal growth factor preservation on intestinal growth. Lancet. 1993 Apr 3;341(8849):843-8. View Abstract

[18] Langmead L, Dawson C, Hawkins C, Banna N, Loo S, Rampton DS. Antioxidant effects of herbal therapies used by patients with inflammatory bowel disease: an in vitro study. Aliment Pharmacol Ther. 2002 Feb;16(2):197-205. View Abstract

[19] Parcell S. Sulfur in human nutrition and applications in medicine. Altern Med Rev. 2002 Feb;7(1):22-44. Review. View Paper

DIGESTION RESEARCH

Milda Stuknytė, Margherita Maggioni, Stefano Cattaneo, Paola De Luca, Amelia Fiorilli, Anita Ferraretto, Ivano De Noni. Release of wheat gluten exorphins A5 and C5 during in vitro gastrointestinal digestion of bread and pasta and their absorption through an in vitro model of intestinal epithelium. Food Research International, 2015; 72: 208 DOI: 10.1016/j.foodres.2015.04.002.

Matthew Weiser, Jeremy M Simon, Bharati Kochar, Adelaide Tovar, Jennifer W Israel, Adam Robinson, Gregory R Gipson, Matthew S Schaner, Hans H Herfarth, R Balfour Sartor, Dermot P B McGovern, Reza Rahbar, Timothy S Sadiq, Mark J Koruda, Terrence S Furey, Shehzad Z Sheikh. Molecular classification of Crohn’s disease reveals two clinically relevant subtypes. Gut, October 2016 DOI: 10.1136/gutjnl-2016-312518.

Antonio Gonzalez, Embriette Hyde, Naseer Sangwan, Jack A. Gilbert, Erik Viirre, Rob Knight. Migraines Are Correlated with Higher Levels of Nitrate-, Nitrite-, and Nitric Oxide-Reducing Oral Microbes in the American Gut Project Cohort. mSystems, October 2016 DOI: 10.1128/mSystems.00105-16.

 

 

GREEN FOODS

Turmeric tea study:
Dias, I., Ademowo, O., Newey, E. and Griffiths, H. (2015). The Nrf2-ARE activation protect neurones against oxidative stress. Free Radical Biology and Medicine, 86, pp.S30-S31.
Hawkey, C. (2001). COX-1 and COX-2 inhibitors. Best Practice & Research Clinical Gastroenterology, 15(5), pp.801-820.
Lee, J. (2005). Nrf2, a multi-organ protector? The FASEB Journal, 19(9), pp.1061-1066.
Aggarwal B.B, Ichikawa H., Garodia P., Weerasinghe P., Sethi G., Bhatt I.D., Pandey M.K., Shishodia S., Nair M.G. From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer. Expert Opin Ther Targets 2006;10(1):87-118.
Aggarwal B.B., Sundaram C., Malani N., Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol. 2007;595:1-75.
Aggarwal B.B., Yuan W., Li S., Gupta S.C. Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric. Mol Nutr Food Res. 2013;57(9):1529-42.
Potential role of herbal remedies in stem cell therapy: proliferation and differentiation of human mesenchymal stromal cells. Vindya Lankika Udalamaththa, Chanika Dilumi Jayasinghe and Preethi Vidya Udagama. Stem Cell Research & Therapy2016,7:110. DOI: 10.1186/s13287-016-0366-4.

RESEARCH
L.N. Yelland, B.J. Gajewski, J. Colombo, R.A. Gibson, M. Makrides, S.E. Carlson. Predicting the effect of maternal docosahexaenoic acid (DHA) supplementation to reduce early preterm birth in Australia and the United States using results of within country randomized controlled trials. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2016; 112: 44 DOI: 10.1016/j.plefa.2016.08.007

Cherrie L. Small, Lydia Xing, Joseph B. McPhee, Hong T. Law, Brian K. Coombes. Acute Infectious Gastroenteritis Potentiates a Crohn’s Disease Pathobiont to Fuel Ongoing Inflammation in the Post-Infectious Period. PLOS Pathogens, 2016; 12 (10): e1005907 DOI: 10.1371/journal.ppat.1005907

Malgorzata Dobosz-Bartoszek, Mark H. Pinkerton, Zbyszek Otwinowski, Srinivas Chakravarthy, Dieter Söll, Paul R. Copeland, Miljan Simonović. Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation. Nature Communications, 2016; 7: 12941 DOI: 10.1038/ncomms12941

Shu G. Chen, Vilius Stribinskis, Madhavi J. Rane, Donald R. Demuth, Evelyne Gozal, Andrew M. Roberts, Rekha Jagadapillai, Ruolan Liu, Kyonghwan Choe, Bhooma Shivakumar, Francheska Son, Shunying Jin, Richard Kerber, Anthony Adame, Eliezer Masliah, Robert P. Friedland. Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans. Scientific Reports, 2016; 6: 34477 DOI: 10.1038/srep34477.

Madhusudana Rao Chikka, Charumathi Anbalagan, Katherine Dvorak, Kyle Dombeck, Veena Prahlad. The Mitochondria-Regulated Immune Pathway Activated in the C. elegans Intestine Is Neuroprotective. Cell Reports, 2016; 16 (9): 2399 DOI: 10.1016/j.celrep.2016.07.077

Shiran Salomon-Zimri, Micaela Johanna Glat, Yael Barhum, Ishai Luz, Anat Boehm-Cagan, Ori Liraz, Tali Ben-Zur, Daniel Offen, Daniel M. Michaelson. Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment. Journal of Alzheimer’s Disease, Volume 53, Number 4, 2016; Pages 1443-1458.

Marc A. Mitchell, David D. Wartinger. Validation of a Functional Pyelocalyceal Renal Model for the Evaluation of Renal Calculi Passage While Riding a Roller Coaster. The Journal of the American Osteopathic Association, 2016; 116 (10): 647 DOI: 10.7556/jaoa.2016.128

Michelle Beaumont, Julia K. Goodrich, Matthew A. Jackson, Idil Yet, Emily R. Davenport, Sara Vieira-Silva, Justine Debelius, Tess Pallister, Massimo Mangino, Jeroen Raes, Rob Knight, Andrew G. Clark, Ruth E. Ley, Tim D. Spector, Jordana T. Bell. Heritable components of the human fecal microbiome are associated with visceral fat. Genome Biology, 2016; 17 (1) DOI: 10.1186/s13059-016-1052-7.

Joseph P Zackular, Jessica L Moore, Ashley T Jordan, Lillian J Juttukonda, Michael J Noto, Maribeth R Nicholson, Jonathan D Crews, Matthew W Semler, Yaofang Zhang, Lorraine B Ware, M Kay Washington, Walter J Chazin, Richard M Caprioli, Eric P Skaar. Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection. Nature Medicine, 2016; DOI: 10.1038/nm.4174.

Jian Zhen Ou, Jeremy J. Cottrell, Nam Ha, Naresh Pillai, Chu K. Yao, Kyle J. Berean, Stephanie A. Ward, Danilla Grando, Jane G. Muir, Christopher J. Harrison, Udani Wijesiriwardana, Frank R. Dunshea, Peter R. Gibson, Kourosh Kalantar-zadeh. Potential of in vivo real-time gastric gas profiling: a pilot evaluation of heat-stress and modulating dietary cinnamon effect in an animal model. Scientific Reports, 2016; 6: 33387 DOI: 10.1038/srep33387.

Somadina Emineke, Alan J Cooper, Sarah Fouch, Brian R Birch, Bashir A Lwaleed. Diluted honey inhibits biofilm formation: potential application in urinary catheter management? Journal of Clinical Pathology, 2016; jclinpath-2015-203546 DOI: 10.1136/jclinpath-2015-203546

 

 

 

October 2016

 

NEWS

CFS/PACE
2011 PACE paper in The Lancet:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)60096-2/fulltext.
PACE authors’ new analyses:
https://www.wolfson.qmul.ac.uk/image…otocol_based_analysis_final_8th_Sept_2016.pdf.

Robert K. Naviaux et al. Metabolic features of chronic fatigue syndrome. PNAS 2016, vol. 113: 37, E5472–E5480. doi: 10.1073/pnas.1607571113.

Robert K. Naviaux, Metabolic features of the cell danger response. Mitochondrion, Volume 16, May 2014, Pages 7–17. https://dx.doi.org/10.1016/j.mito.2013.08.006.

NEW RELEASES

Castro-Marrero Jesús, Cordero Mario D., Segundo María José, Sáez-Francàs Naia, Calvo Natalia, Román-Malo Lourdes, Aliste Luisa, Fernández de Sevilla Tomás, and Alegre José.

Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in Chronic Fatigue Syndrome? Antioxidants & Redox Signaling. March 10, 2015, 22(8): 679-685. doi:10.1089/ars.2014.6181.

Cannabidiol Reduces The Anxiety Induced By Simulated Public Speaking In Treatment-Naïve Social Phobia Patients”. MM Bergamaschi, Department of Neuroscience and Behavior, School of Medicine of Ribeirão Preto, University of São Paulo, SP, Brazil.

Neuropsychopharmacology, May 2011

“Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing”. P Fusar-Poli, Neuroimaging Section, Division of Psychological Medicine, Institute of Psychiatry, London. Archives of General Psychiatry, January 2009.

BEN BROWN

1.             Sies H, Stahl W, Sevanian A. Nutritional, dietary and postprandial oxidative stress. J Nutr. 2005 May;135(5):969-72.

  1. Zilversmit, D. B. (1979) Atherogenesis: a postprandial phenomenon. Circulation60:473-485.

3.             O’Keefe JH, Gheewala NM, O’Keefe JO. Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. J Am Coll Cardiol. 2008 Jan 22;51(3):249-55.

  1. O’Keefe JH, Bell Postprandial hyperglycemia/hyperlipidemia (postprandial dysmetabolism) is a cardiovascular risk factor. Am J Cardiol. 2007;100(5):899–904.

5.             Bloomer RJ, Kabir MM, Marshall KE, Canale RE, Farney TM. Postprandial oxidative stress in response to dextrose and lipid meals of differing size. Lipids Health Dis. 2010 Jul 27;9:79.

  1. laak EE, et al. Impact of postprandial glycaemia on health and prevention of disease. Obes Rev. 2012 Oct;13(10):923-84.

7.             Monnier L, Mas E, Ginet C, Michel F, Villon L, Cristol JP, Colette C. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA. 2006 Apr  12;295(14):1681-7.

  1. Tominaga M, Eguchi H, Manaka H, Igarashi K, Kato T, Sekikawa A. Impaired glucose tolerance is a risk factor for cardiovascular disease, but not impaired fasting glucose. The Funagata Diabetes Study. Diabetes Care 1999;22:920 –924.
  2. Mellen PB, Bittner V, Herrington DM. Post-challenge glucose predicts coronary atherosclerotic progression in non-diabetic, post-menopausal women. Diabet Med. 2007;24(10):1156-1159

10.         O’Keefe JH, Abuannadi M, Lavie CJ, Bell DS. Strategies for optimizing glycemic control and cardiovascular prognosis in patients with type 2 diabetes mellitus. Mayo Clin Proc. 2011 Feb;86(2):128-38.

  1. Nichols GA, Hillier TA, Brown JB. Normal fasting plasma glucose and risk of type 2 diabetes diagnosis. Am J Med 2008;121:519 –524.

12.         Huang CL, Chang HW, Chang JB, Chen JH, Lin JD, Wu CZ, Pei D, Hung YJ, Lee CH,  Chen YL, Hsieh CH. Normal fasting plasma glucose predicts type 2 diabetes and cardiovascular disease in elderly population in Taiwan. QJM. 2016 Aug;109(8):515-22.13.         Hsiao FC, Hsieh CH, Wu CZ, Hsu CH, Lin JD, Lee TI, Pei D, Chen YL. Elevated fasting glucose levels within normal range are associated with an increased risk  of metabolic syndrome in older women. Eur J Intern Med. 2013 Jul;24(5):425-9.14.         Feinman RD, Pogozelski WK, Astrup A, Bernstein RK, Fine EJ, Westman EC, Accurso A, Frassetto L, Gower BA, McFarlane SI, Nielsen JV, Krarup T, Saslow L, Roth KS, Vernon MC, Volek JS, Wilshire GB, Dahlqvist A, Sundberg R, Childers A, Morrison K, Manninen AH, Dashti HM, Wood RJ, Wortman J, Worm N. Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base. Nutrition. 2015 Jan;31(1):1-13.

  1. Official Statistics. National Diet and Nutrition Survey: results from Years 1 to 4 (combined) of the rolling programme for 2008 and 2009 to 2011 and 2012. From: Public Health Englandand Food Standards Agency. First published: 14 May 2014

16.         Minich DM, Bland JS. Dietary management of the metabolic syndrome beyond macronutrients. Nutr Rev. 2008 Aug;66(8):429-44.

  1. Violi F, et al. Extra virgin olive oil use is associated with improved post-prandial blood glucose and LDL cholesterol in healthy subjects. Nutr Diabetes. 2015 Jul 20;5:e172.
  2. Wien M, et al. A randomized 3×3 crossover study to evaluate the effect of Hass avocado intake on post-ingestive satiety, glucose and insulin levels, and subsequent energy intake in overweight adults. Nutr J. 2013 Nov 27;12:155.
  3. Beejmohun V, et al. Acute effect of Ceylon cinnamon extract on postprandial glycemia: alpha-amylase inhibition, starch tolerance test in rats, and randomized crossover clinical trial in healthy volunteers. BMC Complement Altern Med. 2014 Sep 23;14:351.
  4. Shimabukuro M, et al. Effects of the brown rice diet on visceral obesity and endothelial function: the BRAVO study. Br J Nutr. 2014 Jan 28;111(2):310-20.
  5. Thompson SV, Winham DM, Hutchins AM. Bean and rice meals reduce postprandial glycemic response in adults with type 2 diabetes: a cross-over study. Nutr J. 2012 Apr 11;11:23.
  6. Josse AR, Kendall CW, Augustin LS, Ellis PR, Jenkins DJ. Almonds and postprandial glycemia–a dose-response study. Metabolism. 2007 Mar;56(3):400-4.
  7. Ostman E, et al. Vinegar supplementation lowers glucose and insulin responses and increases satiety after a bread meal in healthy subjects. Eur J Clin Nutr. 2005 Sep;59(9):983-8.

24.         Dunstan DW, Kingwell BA, Larsen R, Healy GN, Cerin E, Hamilton MT, Shaw JE, Bertovic DA, Zimmet PZ, Salmon J, Owen N. Breaking up prolonged sitting reduces postprandial glucose and insulin responses. Diabetes Care. 2012 May;35(5):976-83.

BRAIN HEALTH – PATRICK HOLFORD

  1. Council for Evidence-based Psychiatry (CEP), 2013 data; cepuk.org/2015/04/10/latest-prescription-data-shows-consumption-psychiatric-drugs-continues-soar/
  2. C. Coupland et al., ‘Antidepressant use and risk of adverse outcomes in older people: population-based cohort study’, British Medical Journal (2011), 2 Aug; 343: d4,551; www.ncbi.nlm.nih.gov/pubmed/21810886
  3. Seewww.telegraph.co.uk/news/health/news/12126146/Antidepressants-can-raise-the-risk-of-suicide-biggest-ever-review-finds.htmlalso T. Sharma et al., ‘Suicidality and aggression during antidepressant treatment: systematic review and meta-analyses based on clinical study reports’, British Medical Journal (2016), 27 Jan; 352: i65; www.ncbi.nlm.nih.gov/pubmed/26819231
  4. M. Pirmohamed et al., ‘Adverse drug reactions as cause of admission to hospital: prospective analysis of 18,820 patients’, British Medical Journal(2004), 3 Jul; 329(7,456): 15–19; www.ncbi.nlm.nih.gov/pubmed/15231615
  5. ‘Medical error is the fifth-leading cause of death in the US’, Medical News Today, Jun. 2007;www.medicalnewstoday.com/releases/75042.php
  6. M.A. Makary and M. Daniel, ‘Medical error: the third leading cause of death in the US’, BMJ(2016); May 3; 353: i2,139
  7. J. Le Noury et al., ‘Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence’, British Medical Journal(2015); 351: h4,320; study329.org/wp-content/uploads/2015/09/Study-329-Final.pdf
  8. Seecepuk.org/.
  9. Seesecure.avaaz.org/en/petition/Stop_Drug_Companies_Killing_for_Profits/%5D.
  10. Seewww.dailymail.co.uk/health/article-3234334/Prescription-pills-Britain-s-biggest-killer-effects-drugs-taken-insomnia-anxiety-kill-thousands-doctors-hand-like-Smarties.html#ixzz3mAz6KDRz.
  11. Seewww.youtube.com/watch?v=_9cfjKOmPF8.
  12. A.D. Smith and K. Yaffe, ‘Dementia can be prevented: statement supported by international experts’, Journal of Alzheimer’s Disease38 (2014); 699–703; file:///Users/admin/Downloads/igedpreventionstatementg8_2014__2_.pdf
  13. M. Beydoun et al., ‘Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis’, BMC Public Health(2014), 14: 643; bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-14-643
  14. The research councils spent £156,000. For Food for the Brain’s campaign, seewww.foodforthebrain.org/alzheimers-prevention.aspx.
  15. M.A. Arroll et al., ’Nutritional interventions for the adjunctive treatment of schizophrenia: a brief review’, Nutr. J.(2014), 16 Sep;www.ncbi.nlm.nih.gov/pubmed/25228271
  16. J. Sarris et al., ‘Nutritional medicine as mainstream in psychiatry’, The Lancet(2015); 23), 271–4; dx.doi.org/10.1016/S2215-036614)00051-0

ADAPTATION – CHRIS NEWBOLD

[1] OED Online. Oxford University Press, September 2016.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

2 Chopra D, Tanzi RE. Supergenes. 2015. UK: Penguin

3 Previc F The Dopaminergic Mind in Human Evolution and History 2009; Cambridge University Press

4 Abdulamir HA1, Abdul-Rasheed OF, Abdulghani EA. “Low oxytocin and melatonin levels and their possible role in the diagnosis and prognosis in Iraqi autistic children.“Saudi Med J. 2016 Jan;37(1):29-36. doi: 10.15537/smj.2016.1.13183.

5 McEwan Neuroimage 2009;47(3):911-913

6 Jankord. Ann N Y Acad Sci 2008;148:64-73

7 Sapolsky R M Why zebras don’t get ulcers 1998 W H Freeman and Co USA

8 Babri et al. Strain-dependent effects of prenatal maternal immune activation on anxiety- and depression-like behaviors in offspring. Brain Behav Immun. 2014 Mar;37:164-76.

9 Weir. Autism, schizophrenia and other disorders may have roots in life’s earliest stages. Monitor on Psychology February 2012, Vol 43, No. 2

10 Marques et al. The influence of maternal prenatal and early childhood nutrition and maternal prenatal stress on offspring immune system development and neurodevelopmental disorders. Front Neurosci. 2013; 7: 120.

11 Botiglieri S-Adenosyl-L-methionine (SAMe): from the bench to the bedside—molecular basis of a pleiotrophic molecule. Am J Clin Nutr November 2002  vol. 76 no. 5 1151S-1157S

12 Sabol SZ et al. A functional polymorphism in the monoamine oxidase A gene promoter. Human Genet. 1998; 103(3): 273–279.

13 Meyer JH et al. Elevated monoamine oxidase a levels in the brain: an Explanation for the monoamine imbalance of major depression. Arch Gen Psychiatry. 2006; 63(11):1209-1216.

14 Zhang Y et al. A meta-analysis on relationship of MAOB intron 13 polymorphisms, interactions with smoking/COMT H158L polymorphisms with the risk of PD. Int J Neurosci. 2016; 126(5): 400-7.

15 Cohen IL et al. Autism severity is associated with child and maternal MAOA genotypes. Clinical Genet. 2011; 79 (4): 355-362.

16 Genetics Home Reference. COMT. 2007. Available at: https://ghr.nlm.nih.gov/gene/COMT

17 Hettema JM et al. COMT contributes to genetic susceptibility shared among anxiety spectrum phenotypes. Biol Psychiatry. 2008; 64(4): 302–310.

18 Pandolfo G et al. Association of the COMT synonymous polymorphism Leu136Leu and missense variant Vak158Met with mood disorders. J Affect Disord. 2015; 177:108-113.

19 Mandelli L et al.  Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders. Int.J.Neuropsychopharmacol. 2007; 10 (4): 437-447.

20 Hallehand H et al. Association between catechol-O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults. Am J Med Genet B Neuropsychiatr Genet. 2009;150B(3):403-410.

21 Simpson EH et al. Genetic variation in COMT activity impacts learning and dopamine release capacity in the striatum. Learn Mem. 2014; 21(4): 205–214.

22 Cengiz FB et al. Genetic polymorphism of the serotonin transporter gene, SLC6A4 rs16965628, is associated with obsessive compulsive disorder. Genet Test Mol Biomarkers. 2015; 19 (5): 228-234.

23 Juhan, D. Job’s Body: A Handbook for Bodywork. Barrytown; Station Hill Press.

LIGHT SENSITIVITY CASE HISTORY – JENNIFER WILLIAMS

  1. Kukkonen K, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T,Tuure T, Kuitunen M (2007) Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: A randomized, double-blind, placebo-controlled Journal of Allergy and Clinical Immunology 119:192-8.

 

  1. Mizuguchi D, Das H, Matsushita AK, Maeyama C, Umehara K, Ohtoshi T, Kojima J, Nishida K, Takahashi K,Fukui, H (2008). Suppression of histamine signaling by probiotic Lac-B: a possible mechanism of its anti-allergic Journal of Pharmacological Sciences, 107:159-166.

 

  1. DeAngelis YM, Gemmer CM, Kaczvinsky, JR, Kenneally DC, Schwartz JR, Dawson Jr TL (2005) Three etiologic facets of dandruff and seborrheic dermatitis: malassezia fungi, sebaceous lipids and individual Journal of Investigative Dermatology Symposium  Proceedings,

10:295–297.

  1. Tollesson A, Frithz A, Berg A, Karlman G (1993) Essential fatty acids in infantile seborrheic dermatitis. Journal of the American Academy of Dermatology, 28: 957-961.
  • Preuss CV, Wood TC, Szumlanski CL, Raftogianis RB, Otterness DM, Girard B, Scott MC, Weinshilboum RM (1998) Human histamine n-methyltransferase pharmacogenetics: common genetic polymorphisms that alter Molecular Pharmacology, 53:708-17.
  1. Barbosa PR, Stabler SP, Machado ALK, Braga RC, Hirata RDC, Hirata MH, Sampaio-Neto LF, Allen RH, Guerra-Shinohara EM (2007) Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant European Journal of Clinical Nutrition, 62:1010–1021.
  2. Lewis CA (2015) Enteroimmunology: a guide to the prevention and treatment of chronic inflammatory Carrabelle, Florida: Psy Press.
  3. McGuire M, Beerman KA (2015) 3rd Nutritional sciences:from fundamentals to food.

Belmont, California: Wadsworth, Cengage Learning.

  1. Bolander-Gouaille C (2002) 2nd Focus on homocysteine and the vitamins involved in its metabolism: involved in its metabolism.France:Springer.
  2. Zeisel SH (2006) Choline: Critical role during fetal development and dietary requirements in adults. Annual Review of Nutrition, 26: 229-250.
  3. Mitchell ES, Conus N, Kaput J (2014) B vitamin polymorphisms and behavior: Evidence of associations with neurodevelopment, depression, schizophrenia, bipolar disorder and cognitive decline. Neuroscience & Biobehavioral Reviews, 47: 307–320.
  1. University of Bristol, centre for academic primary care. MYMOP general information. [Online]Available at: https://www.bristol.ac.uk/primaryhealthcare/resources/mymop/general- information/

RESEARCH
Lien Wang, Yan Zhang, Zhiwei Wang, Nian Gong, Tae Dong Kweon, Benjamin Vo, Chaoran Wang, Xiuli Zhang, Jae Yoon Chung, Amal Alachkar, Xinmiao Liang, David Z. Luo, Olivier Civelli. The Antinociceptive Properties of the Corydalis yanhusuo Extract. PLOS ONE, 2016; 11 (9): e0162875 DOI: 10.1371/journal.pone.0162875

  1. A. Lopez, B. M. Miller, F. Rivera-Chavez, E. M. Velazquez, M. X. Byndloss, A. Chavez-Arroyo, K. L. Lokken, R. M. Tsolis, S. E. Winter, A. J. Baumler. Virulence factors enhance Citrobacter rodentium expansion through aerobic respiration. Science, 2016; 353 (6305): 1249 DOI: 10.1126/science.aag3042

 

Freddie C. Hamdy, et al. 10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer. New England Journal of Medicine, 2016; DOI: 10.1056/NEJMoa1606220

Jenny L. Donovan, et al. Patient-Reported Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer. New England Journal of Medicine, 2016; DOI: 10.1056/NEJMoa1606221

Mathias Rask-Andersen, David Martinsson, Muhammad Ahsan, Stefan Enroth, Weronica E Ek, Ulf Gyllensten, Åsa Johansson. Epigenome Wide Association Study Reveals Differential DNA Methylation in Individuals With a History of Myocardial Infarction. Human Molecular Genetics, 2016; ddw302 DOI: 10.1093/hmg/ddw302

Antonios Chronopoulos, Benjamin Robinson, Muge Sarper, Ernesto Cortes, Vera Auernheimer, Dariusz Lachowski, Simon Attwood, Rebeca García, Saba Ghassemi, Ben Fabry, Armando del Río Hernández. ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion. Nature Communications, 2016; 7: 12630 DOI: 10.1038/ncomms12630

Adrian R Martineau, Christopher J Cates, Mitsuyoshi Urashima, Megan Jensen, Alex P Griffiths, Ulugbek Nurmatov, Aziz Sheikh, Chris J Griffiths. Vitamin D for the management of asthma. Cochrane Library, 2016 DOI: 10.1002/14651858.CD011511.pub2.

Nupur Bhattacharya et al. Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8 T Cell-Mediated Immunity in Colorectal Cancer. Immunity, August 2016 DOI: 10.1016/j.immuni.2016.08.008

Stephen P. Juraschek, Allan C. Gelber, Hyon K. Choi, Lawrence J. Appel, Edgar R. Miller. Effects of the Dietary Approaches To Stop Hypertension (DASH) Diet and Sodium Intake on Serum Uric Acid. Arthritis & Rheumatology, 2016; DOI: 10.1002/art.39813

 

September 2016

NEWS

Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis . A. Trovato et al. Immunity & Ageing201613:23

DOI: 10.1186/s12979-016-0078-8

Changes in Burnout and Satisfaction With Work-Life Balance in Physicians and the General US Working Population Between 2011 and 2014.

Shanafelt, Tait D. et al. Mayo Clinic Proceedings 2016, Volume 90 , Issue 12 , 1600-13.

Clinical research evidence of cupping therapy in China: a systematic literature review

Huijuan Cao1, Mei Han1, Xun Li1, Shangjuan Dong1, Yongmei Shang1, Qian Wang1, Shu Xu1 and Jianping Liu

BMC Complementary and Alternative MedicineThe official journal of the International Society for Complementary Medicine Research (ISCMR)201010:70

DOI: 10.1186/1472-6882-10-70.
Journal of Traditional Chinese Medical Sciences

Volume 1, Issue 1, 1 July 2014, Pages 49–61. Cupping therapy for acute and chronic pain management: a systematic review of randomized clinical trials

Huijuan Caoa, Xun Lia, Xue Yanb, Nissi S. Wangc, Alan Bensoussand, Jianping Liua, et al. doi:10.1016/j.jtcms.2014.11.003.

Serum and retinal responses to three different doses of macular carotenoids over 12 weeks of supplementation. Experimental Eye Research, Volume 151, October 2016, Pages 1-8.  James M. Stringham, Nicole T. Stringham.

Eleanor Pullenayegum, PhD et al. Live Attenuated Versus Inactivated Influenza Vaccine in Hutterite Children: A Cluster Randomized Blinded Trial. Annals of Internal Medicine, August 2016 DOI: 10.7326/M16-0513.

Bobak Heydari, et al. Effect of Omega-3 Acid Ethyl Esters on Left Ventricular Remodeling After Acute Myocardial InfarctionClinical Perspective. Circulation, 2016; 134 (5): 378 DOI: 10.1161/CIRCULATIONAHA.115.019949

BEN BROWN
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  19. Al-Karawi D, Al Mamoori DA, Tayyar Y. The Role of Curcumin Administration in Patients with Major Depressive Disorder: Mini Meta-Analysis of Clinical Trials. Phytother Res. 2016 Feb;30(2):175-83.
  20. McNamara RK. Long-chain omega-3 fatty acid deficiency in mood disorders: rationale for treatment and prevention. Curr Drug Discov Technol. 2013 Sep;10(3):233-44.
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ANTIOXIDANTS

G J McBean, M G López and F K Wallner. Redox-based therapeutics in neurodegenerative disease. British Journal of Pharmacology, 1 AUG 2016 DOI: 10.1111/bph.13551.

Do You Know The Power of the Nrf2 Pathway? https://www.drperlmutter.com/good-news-nrf2/?hvid=4LdnJk.

Egner PA, et al. (2014) Rapid and sustainable detoxication of airborne pollutants by

broccoli sprout beverage: Results of a randomized clinical trial in China. Cancer Prev

Res (Phila) 7(8):813-823.
Kensler TW, et al. (2013) Keap1-nrf2 signaling: a target for cancer prevention by

sulforaphane. Top Curr Chem 329:163-177.
Clin Pharmacol. 2014 Feb 3;6:19-34. doi: 10.2147/CPAA.S35078. eCollection 2014.

The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders. Gao B1, Doan A1, Hybertson BM1. Free online at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917919.

Kanwaljit Singh, Susan L. Connors, Eric A. Macklin, Kirby D. Smith, Jed W. Fahey, Paul Talalay, and Andrew W. Zimmerman. Sulforaphane treatment of autism spectrum disorder (ASD). PNAS, October 13, 2014 DOI: 10.1073/pnas.1416940111.

Saskia F. Erttmann, Anetta Hartlova, Marta Sloniecka, Faizal A.M. Raffi, Ava Hosseinzadeh, Tomas Edgren, Reza Rofougaran, Ulrike Resch, Maria Fällman, Torben Ek, and Nelson O. Gekara. Loss of the DNA Damage Repair Kinase ATM Impairs Inflammasome-Dependent Anti-Bacterial Innate Immunity. Immunity, 2016 DOI: 10.1016/j.immuni.2016.06.018.

Trends Cell Biol. 2011 Oct; 21(10): 569–576.

Published online 2011 Aug 6. doi:  10.1016/j.tcb.2011.06.008

Taking a “good” look at free radicals in the aging process

Siegfried Hekimi,* Jérôme Lapointe, and Yang Wen, free online at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074523.

Circulation. 2013 May 7;127(18):1888-902. doi: 10.1161/CIRCULATIONAHA.112.132159. Epub 2013 Apr 5. NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. Gray SP1, Di Marco E, Okabe J, Szyndralewiez C, Heitz F, Montezano AC, de Haan JB, Koulis C, El-Osta A, Andrews KL, Chin-Dusting JP, Touyz RM, Wingler K, Cooper ME, Schmidt HH, Jandeleit-Dahm KA.

CHRIS MELETIS – ENERGY
References:

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IHCAN Student

  1. Kirby E D et al. Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2. eLife 2013, 2: 1-23. https://doi.org/10.7554/eLife.00362
  2. Cahill L et al. Enhanced human memory consolidation with post-learning stress: interaction with the degree of arousal at encoding. Learn. Mem 2003. 10, 270–274. 10.1101/lm.62403
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  4. Clifford D and Curtis L, Motivational interviewing in nutrition and fitness. The Guildford Press, 2016
  5. Gardner B et al. Making health habitual: the psychology of “habit-formation” and general practice.The British Journal of General Practice 2012, 62: 664–666.

RESEARCH

Yassine HN, Rawat V, Mack WJ, Quinn JF, Yurko-Mauro K, Bailey-Hall E, Aisen PS, Chui HC, Schneider LS. The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer’s disease. Alzheimers Res Ther. 2016 Jun 30;8:25. PubMed.

K Rosenke et al. Plasmodium parasitemia associated with increased survival in Ebola virus-infected patients. Clinical Infectious Diseases, 2016; DOI: 10.1093/cid/ciw452.

Carlos Celis-Morales, et al Effect of personalized nutrition on health-related behaviour change: evidence from the Food4me European randomized controlled trial. International Journal of Epidemiology, 2016; dyw186 DOI: 10.1093/ije/dyw186

Henrik M. Roager, Lea B. S. Hansen, Martin I. Bahl, Henrik L. Frandsen, Vera Carvalho, Rikke J. Gøbel, Marlene D. Dalgaard, Damian R. Plichta, Morten H. Sparholt, Henrik Vestergaard, Torben Hansen, Thomas Sicheritz-Pontén, H. Bjørn Nielsen, Oluf Pedersen, Lotte Lauritzen, Mette Kristensen, Ramneek Gupta, Tine R. Licht. Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut. Nature Microbiology, 2016; 1: 16093 DOI: 10.1038/nmicrobiol.2016.93

August 2016

IHCAN AUGUST references

NEWS

SACN vitamin D and health report, from

Public Health England

First published: 21 July 2016

Part of: SACN: reports and position statements and Obesity and healthy eating The Scientific Advisory Committee on Nutrition (SACN) recommendations on vitamin D: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/537616/SACN_Vitamin_D_and_Health_report.pdf

US statistics:

Nahin RL, Barnes PM, Stussman BJ. Expenditures on complementary health approaches: United States, 2012. (433KB PDF) National Health Statistics Reports. Hyattsville, MD: National Center for Health Statistics. 2016.

NEW RELEASES
ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies

Liana C. Del Gobbo et al. JAMA Intern Med. Published online June 27, 2016. doi:10.1001/jamainternmed.2016.2925

BEN BROWN

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Further reading suggested by Dr Christen Rune Stensvold, PhD (https://www.blastocystis.net):

Pepper, J., & Rosenfeld, S. (2012). The emerging medical ecology of the human gut microbiome Trends in Ecology & Evolution, 27 (7), 381-384 DOI: 10.1016/j.tree.2012.03.002

Dethlefsen, L., & Relman, D. (2010). Colloquium Paper: Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation Proceedings of the National Academy of Sciences, 108 (Supplement_1), 4554-4561 DOI: 10.1073/pnas.1000087107

Stensvold, C., Christiansen, D., Olsen, K., & Nielsen, H. (2011). Blastocystis sp. Subtype 4 is Common in Danish Blastocystis-Positive Patients Presenting with Acute Diarrhea American Journal of Tropical Medicine and Hygiene, 84 (6), 883-885 DOI: 10.4269/ajtmh.2011.11-0005

Domínguez-Márquez, M., Guna, R., Muñoz, C., Gómez-Muñoz, M., & Borrás, R. (2009). High prevalence of subtype 4 among isolates of Blastocystis hominis from symptomatic patients of a health district of Valencia (Spain) Parasitology Research, 105 (4), 949-955 DOI: 10.1007/s00436-009-1485-y

Stensvold, C., (2012). Thinking Blastocystis Out Of The Box. Trends in Parasitology DOI: 10.1016/j.pt.2012.05.004

JOINTS and BONES
Originally published as “Biological and therapeutic effects of ortho-silicic acid and some ortho-silicic acid-releasing compounds: new perspectives for therapy”, Nutr Metab (Lond). 2013; 10: 2. Published online 2013 Jan 8. doi:  10.1186/1743-7075-10-2 as an Open Access article by BioMed Cantral.

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GLUTEN and AUTO-IMMUNITY

Genome Med. 2016 Apr 21;8(1):43. (doi: 10.1186/s13073-016-0299-7)

An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis. Chen J1, Wright K2, Davis JM2, Jeraldo P3, Marietta EV4, Murray J4, Nelson H3, Matteson EL2, Taneja V5.

Arthritis Rheumatol. 2016 Jun 23. doi: 10.1002/art.39785. [Epub ahead of print]

Human Gut-Derived Prevotella histicola Suppresses Inflammatory Arthritis in Humanized Mice. Marietta EV, Murray JA, Luckey DH, Jeraldo PR, Lamba A, Patel R, Luthra HS, Mangalam A2, Taneja V.

 

Marietta EV, Gomez AM, Yeoman C, Tilahun AY, Clark CR, Luckey DH, Murray JA, White BA, Kudva YC, Rajagopalan G. Low incidence of spontaneous type 1 diabetes in non-obese diabetic mice raised on gluten-free diets is associated with changes in the intestinal microbiome. PLoS One. 2013; 8(11):e78687. Epub 2013 Nov 13. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078687

RESEARCH
Cospeciation of gut microbiota with hominids

Andrew H. Moeller et al. Science  22 Jul 2016: Vol. 353, Issue 6297, pp. 380-382
doi: 10.1126/science.aaf3951

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour. Anthony J. Filiano et al. Nature 535, 425–429

(21 July 2016) (doi: 10.1038/nature18626).

Investigation of 2 Types of Self-administered Acupressure for Persistent Cancer-Related Fatigue in Breast Cancer Survivors: A Randomized Clinical Trial

Suzanna M. Zick, ND, MPH1,2; Ananda Sen, PhD1,3; Gwen K. Wyatt, PhD, RN4; Susan L. Murphy, PhD5,6; J. Todd Arnedt, PhD7,8,9; Richard E. Harris, PhD10

JAMA Oncol. Published online July 07, 2016.

doi: 10.1001/jamaoncol.2016.1867).

Pietro Ghezzi, Vincent Jaquet, Fabrizio Marcucci, Harald H.H.W. Schmidt. The oxidative stress theory of disease: levels of evidence and epistemological aspects. British Journal of Pharmacology, 2016; DOI: 10.1111/bph.13544

July 2016

 

WELCOME
Ann Intern Med. 2005 Feb 15;142(4):260-73 (doi: 10.7326/0003-4819-142-4-200502150-00008).
Systematic review: the relationship between clinical experience and quality of health care. Choudhry NK1, Fletcher RH, Soumerai SB.

NEWS

Evaluation of a functional medicine approach to treating fatigue, stress, and digestive issues in women. Susanne M. Cutshall,
Larry R. Bergstrom, Daniel J. Kalish. Complementary Therapies in Clinical Practice, May 2016, Volume 23, Pages 75–81.
DOI: https://dx.doi.org/10.1016/j.ctcp.2016.03.005.
Buffington et al. Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring. Cell, 2016 DOI: 10.1016/j.cell.2016.06.001
IHCANchat
Guess, et al. A randomised controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes. Nutrition & Metabolism 2015 Oct; 12: 36.

BEN BROWN

1. Juby AG, Hanly MG, Lukaczer D. Clinical challenges in thyroid disease: Time for a new approach? Maturitas. 2016 May;87:72-8.
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3. Karbownik-Lewińska M, Kokoszko-Bilska A. Oxidative damage to macromolecules in the thyroid – experimental evidence. Thyroid Res. 2012 Dec 27;5(1):25.
4. Mancini A, et al. Thyroid Hormones, Oxidative Stress, and Inflammation. Mediators Inflamm. 2016;2016:6757154.
5. Chen A, Kim SS, Chung E, Dietrich KN. Thyroid hormones in relation to lead, mercury, and cadmium exposure in the National Health and Nutrition Examination Survey, 2007-2008. Environ Health Perspect. 2013 Feb;121(2):181-6.
6. Fortunato RS, Ferreira AC, Hecht F, Dupuy C, Carvalho DP. Sexual dimorphism and thyroid dysfunction: a matter of oxidative stress? J Endocrinol. 2014 Apr 22;221(2):R31-40.
7. Vita R, Lapa D, Vita G, Trimarchi F, Benvenga S. A patient with stress-related onset and exacerbations of Graves disease. Nat Clin Pract Endocrinol Metab. 2009 Jan;5(1):55-61.
8. The Lancet Diabetes Endocrinology. Iodine deficiency in the UK: grabbing the low-hanging fruit. Lancet Diabetes Endocrinol. 2016 Jun;4(6):469.
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12. Farhangi MA, Keshavarz SA, Eshraghian M, Ostadrahimi A, Saboor-Yaraghi AA. The effect of vitamin A supplementation on thyroid function in premenopausal women. J Am Coll Nutr. 2012 Aug;31(4):268-74.
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15. Toulis KA, Anastasilakis AD, Tzellos TG, Goulis DG, Kouvelas D. Selenium supplementation in the treatment of Hashimoto’s thyroiditis: a systematic review and a meta-analysis. Thyroid. 2010 Oct;20(10):1163-73.
16. Palinkas LA, Reedy KR, Smith M, Anghel M, Steel GD, Reeves D, Shurtleff D, Case HS, Van Do N, Reed HL. Psychoneuroendocrine effects of combined thyroxine and triiodothyronine versus tyrosine during prolonged Antarctic residence. Int J Circumpolar Health. 2007 Dec;66(5):401-17.
17. Felker P, Bunch R, Leung AM. Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism. Nutr Rev. 2016 Apr;74(4):248-58.
18. Sathyapalan T, Manuchehri AM, Thatcher NJ, Rigby AS, Chapman T, Kilpatrick ES, Atkin SL. The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: a randomized, double-blind, crossover study. J Clin Endocrinol Metab. 2011 May;96(5):1442-9.
19. Messina M, Redmond G. Effects of soy protein and soybean isoflavones on thyroid function in healthy adults and hypothyroid patients: a review of the relevant literature. Thyroid. 2006 Mar;16(3):249-58.
20. Peckham S, Lowery D, Spencer S. Are fluoride levels in drinking water associated with hypothyroidism prevalence in England? A large observational study of GP practice data and fluoride levels in drinking water. J Epidemiol Community Health. 2015 Jul;69(7):619-24.
21. Chandra AK, Goswami H, Sengupta P. Dietary calcium induced cytological and biochemical changes in thyroid. Environ Toxicol Pharmacol. 2012 Sep;34(2):454-65.
22. Wang N, Zhou Y, Fu C, Wang H, Huang P, Wang B, Su M, Jiang F, Fang H, Zhao Q, Chen Y, Jiang Q. Influence of Bisphenol A on Thyroid Volume and Structure Independent of Iodine in School Children. PLoS One. 2015 Oct 23;10(10):e0141248.
23. Pelletier C, Doucet E, Imbeault P, Tremblay A. Associations between weight loss-induced changes in plasma organochlorine concentrations, serum T(3) concentration, and resting metabolic rate. Toxicol Sci. 2002 May;67(1):46-51.
24. Di Matola T, Zeppa P, Gasperi M, Vitale M. Thyroid dysfunction following a kelp-containing marketed diet. BMJ Case Rep. 2014 Oct 29;2014.
25. Sategna-Guidetti C, et al. Prevalence of thyroid disorders in untreated adult celiac disease patients and effect of gluten withdrawal: an Italian multicenter study. Am J Gastroenterol. 2001 Mar;96(3):751-7.

PANEL: Antje Brüser, Angela Schulz, Sven Rothemund, Albert Ricken, Davide Calebiro, Gunnar Kleinau, Torsten Schöneberg. The Activation Mechanism of Glycoprotein Hormone Receptors with Implications in the Cause and Therapy of Endocrine Diseases. Journal of Biological Chemistry, 2016; 291 (2): 508 DOI: 10.1074/jbc.M115.701102

BRAIN HEALTH
Miguel’s key papers and suggestions for further reading

Bhullar, K. S. & Rupasinghe, H. P. (2013) Polyphenols: multipotent therapeutic agents in neurodegenerative diseases. Oxid Med Cell Longev, 2013pp. 891748.

Cascalheira, J. F., Goncalves, M., Barroso, M., Castro, R., Palmeira, M., Serpa, A., Dias-Cabral, A. C., Domingues, F. C. & Almeida, S. (2015) Association of the transcobalamin II gene 776C –> G polymorphism with Alzheimer’s type dementia: dependence on the 5, 10-methylenetetrahydrofolate reductase 1298A –> C polymorphism genotype. Ann Clin Biochem, 52(Pt 4) pp. 448-55.

Fowler, A. K., Hewetson, A., Agrawal, R. G., Dagda, M., Dagda, R., Moaddel, R., Balbo, S., Sanghvi, M., Chen, Y., Hogue, R. J., Bergeson, S. E., Henderson, G. I. & Kruman, Ii (2012) Alcohol-induced one-carbon metabolism impairment promotes dysfunction of DNA base excision repair in adult brain. J Biol Chem, 287(52) pp. 43533-42.

Iriti, M. & Varoni, E. M. (2015) Melatonin in Mediterranean diet, a new perspective. J Sci Food Agric, 95(12) pp. 2355-9.

Lopes Da Silva, S., Vellas, B., Elemans, S., Luchsinger, J., Kamphuis, P., Yaffe, K., Sijben, J., Groenendijk, M. & Stijnen, T. (2014) Plasma nutrient status of patients with Alzheimer’s disease: Systematic review and meta-analysis. Alzheimers Dement, 10(4) pp. 485-502.

Pallauf, K., Giller, K., Huebbe, P. & Rimbach, G. (2013) Nutrition and healthy ageing: calorie restriction or polyphenol-rich “MediterrAsian” diet? Oxid Med Cell Longev, 2013pp. 707421.

Pedret, A., Valls, R. M., Fernandez-Castillejo, S., Catalan, U., Romeu, M., Giralt, M., Lamuela-Raventos, R. M., Medina-Remon, A., Arija, V., Aranda, N., Espinel, A., Delgado, M. A. & Sola, R. (2012) Polyphenol-rich foods exhibit DNA antioxidative properties and protect the glutathione system in healthy subjects. Mol Nutr Food Res, 56(7) pp. 1025-33.

Rai, V. (2016) Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism and Alzheimer Disease Risk: a Meta-Analysis. Mol Neurobiol, pp.

Scoditti, E., Capurso, C., Capurso, A. & Massaro, M. (2014) Vascular effects of the Mediterranean diet-part II: role of omega-3 fatty acids and olive oil polyphenols. Vascul Pharmacol, 63(3) pp. 127-34.
Shen, L. & Ji, H. F. (2015) Associations between Homocysteine, Folic Acid, Vitamin B12 and Alzheimer’s Disease: Insights from Meta-Analyses. J Alzheimers Dis, 46(3) pp. 777-90.

Toledo, E., Salas-Salvado, J., Donat-Vargas, C., Buil-Cosiales, P., Estruch, R., Ros, E., Corella, D., Fito, M., Hu, F. B., Aros, F., Gomez-Gracia, E., Romaguera, D., Ortega-Calvo, M., Serra-Majem, L., Pinto, X., Schroder, H., Basora, J., Sorli, J. V., Bullo, M., Serra-Mir, M. & Martinez-Gonzalez, M. A. (2015) Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial. JAMA Intern Med, 175(11) pp. 1752-60.

Tuttolomondo, A., Casuccio, A., Butta, C., Pecoraro, R., Di Raimondo, D., Della Corte, V., Arnao, V., Clemente, G., Maida, C., Simonetta, I., Miceli, G., Lucifora, B., Cirrincione, A., Di Bona, D., Corpora, F., Maugeri, R., Iacopino, D. G. & Pinto, A. (2015) Mediterranean Diet in patients with acute ischemic stroke: Relationships between Mediterranean Diet score, diagnostic subtype, and stroke severity index. Atherosclerosis, 243(1) pp. 260-7.

RESEARCH

Daniel Brugger, Wilhelm M. Windisch. Subclinical zinc deficiency impairs pancreatic digestive enzyme activity and digestive capacity of weaned piglets. British Journal of Nutrition, 2016; 1 (doi: 10.1017/S0007114516002105).

Sci Rep. 2016 Jun 3;6:27010. doi: 10.1038/srep27010.
Paternal under-nutrition programs metabolic syndrome in offspring which can be reversed by antioxidant/vitamin food fortification in fathers.
McPherson NO1,2, Fullston T1, Kang WX1, Sandeman LY1, Corbett MA3, Owens JA1, Lane M1,4.

J Med Food. 2016 May 20. [Epub ahead of print] doi: 10.1089/jmf.2016.0030.
Inhibition of TNF-α, IL-1α, and IL-1β by Pretreatment of Human Monocyte-Derived Macrophages with Menaquinone-7 and Cell Activation with TLR Agonists In Vitro.
Pan MH, Maresz K5, Lee PS4, Wu JC4, Ho CT6, Popko J7,8, Mehta DS9, Stohs SJ10, Badmaev V.

Ramon Estruch, Miguel Angel Martínez-González, Dolores Corella, Jordi Salas-Salvadó, Montserrat Fitó, Gemma Chiva-Blanch, Miquel Fiol, Enrique Gómez-Gracia, Fernando Arós, José Lapetra, Lluis Serra-Majem, Xavier Pintó, Pilar Buil-Cosiales, José V Sorlí, Miguel A Muñoz, Josep Basora-Gallisá, Rosa María Lamuela-Raventós, Mercè Serra-Mir, Emilio Ros. Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial. The Lancet Diabetes & Endocrinology, 2016; DOI: 10.1016/S2213-8587(16)30085-7
Moran Yassour et al. Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability. Science Translational Medicine, 2016 DOI: 10.1126/scitranslmed.aad0917 .
Franziska Faber, Lisa Tran, Mariana X. Byndloss, Christopher A. Lopez, Eric M. Velazquez, Tobias Kerrinnes, Sean-Paul Nuccio, Tamding Wangdi, Oliver Fiehn, Renée M. Tsolis, Andreas J. Bäumler. Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion. Nature, 2016; DOI: 10.1038/nature18597 .
Catherine R. Marinac, Sandahl H. Nelson, Caitlin I. Breen, Sheri J. Hartman, Loki Natarajan, John P. Pierce, Shirley W. Flatt, Dorothy D. Sears, Ruth E. Patterson. Prolonged Nightly Fasting and Breast Cancer Prognosis. JAMA Oncology, 2016; DOI: 10.1001/jamaoncol.2016.0164.
Sara Vieira-Silva, Gwen Falony, Youssef Darzi, Gipsi Lima-Mendez, Roberto Garcia Yunta, Shujiro Okuda, Doris Vandeputte, Mireia Valles-Colomer, Falk Hildebrand, Samuel Chaffron, Jeroen Raes. Species–function relationships shape ecological properties of the human gut microbiome. Nature Microbiology, 2016; 16088 DOI: 10.1038/nmicrobiol.2016.88.
Lakshmi Krishnamoorthy, Joseph A Cotruvo, Jefferson Chan, Harini Kaluarachchi, Abigael Muchenditsi, Venkata S Pendyala, Shang Jia, Allegra T Aron, Cheri M Ackerman, Mark N Vander Wal, Timothy Guan, Lukas P Smaga, Samouil L Farhi, Elizabeth J New, Svetlana Lutsenko, Christopher J Chang. Copper regulates cyclic-AMP-dependent lipolysis. Nature Chemical Biology, 2016; DOI: 10.1038/nchembio.2098
Bredesen
Dale E. Bredesen, Edwin C. Amos3, Jonathan Canick4, Mary Ackerley5, Cyrus Raji6, Milan Fiala7, and Jamila Ahdidan, Aging 2016, 8 (6): online at https://www.impactaging.com/papers/v8/n6/full/100981.html.

Bredesen DE. Reversal of cognitive decline: A novel therapeutic program. Aging 2014; 6:707-17. Doi: 10.18632/aging.100690.

June 2016

IHCAN June 2016 references

NEWS
Emily G Severance, Kristin L Gressitt, Catherine R Stallings, Emily Katsafanas, Lucy A Schweinfurth, Christina L Savage, Maria B Adamos, Kevin M Sweeney, Andrea E Origoni, Sunil Khushalani, F Markus Leweke, Faith B Dickerson, Robert H Yolken. Candida albicans exposures, sex specificity and cognitive deficits in schizophrenia and bipolar disorder. npj Schizophrenia, 2016; 2: 16018 DOI: 10.1038/npjschz.2016.18
Martin A Makary, Michael Daniel. Medical error—the third leading cause of death in the US. BMJ, 2016; i2139 DOI: 10.1136/bmj.i2139
Jacquelaine Bartlett, Irene M. Predazzi, Scott M. Williams, William S. Bush, Yeunjung Kim, Stephen Havas, Peter P. Toth, Sergio Fazio, Michael Miller. Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor? Circulation: Cardiovascular Quality and Outcomes, 2016; CIRCOUTCOMES.115.002436 DOI: 10.1161/CIRCOUTCOMES.115.002436
Nutrition. 2016 Feb 13. pii: S0899-9007(16)00075-7. doi: 10.1016/j.nut.2016.01.021. [Epub ahead of print]Is it gluten-free? Relationship between self-reported gluten-free diet adherence and knowledge of gluten content of foods.
Silvester JA1, Weiten D2, Graff LA3, Walker JR3, Duerksen DR4
(Nutrition 2016, doi: 10.1016/j.nut.2016.01.021.)

Katharine A. Rimes, Joanna Ashcroft, Lauren Bryan, Trudie Chalder. Emotional Suppression in Chronic Fatigue Syndrome: Experimental Study.. Health Psychology, 2016; DOI: 10.1037/hea0000341
Toni Ali-Sisto, Tommi Tolmunen, Elena Toffol, Heimo Viinamäki, Pekka Mäntyselkä, Minna Valkonen-Korhonen, Kirsi Honkalampi, Anu Ruusunen, Vidya Velagapudi, Soili M. Lehto. Purine metabolism is dysregulated in patients with major depressive disorder. Psychoneuroendocrinology, 2016; 70: 25 DOI: 10.1016/j.psyneuen.2016.04.017
Hilary P. Browne, Samuel C. Forster, Blessing O. Anonye, Nitin Kumar, B. Anne Neville, Mark D. Stares, David Goulding, Trevor D. Lawley. Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation. Nature, 2016; DOI: 10.1038/nature17645

BEN BROWN

1. Ginsburg GS, Willard HF. Genomic and personalized medicine: foundations and applications. Transl Res. 2009 Dec;154(6):277-87.
2. Minich DM, Bland JS. Personalized lifestyle medicine: relevance for nutrition and lifestyle recommendations. ScientificWorldJournal. 2013 Jun 26;2013:129841.
3. Fenech M, El-Sohemy A, Cahill L, et al. Nutrigenetics and nutrigenomics: viewpoints on the current status and applications in nutrition research and practice. J Nutrigenet Nutrigenomics. 2011;4(2):69-89.
4. Sykiotis GP, Kalliolias GD, Papavassiliou AG. Pharmacogenetic principles in the Hippocratic writings. J Clin Pharmacol. 2005 Nov;45(11):1218-20.
5. Jaiswal YS, Williams LL, A glimpse of Ayurveda e The forgotten history and principles of Indian traditional medicine, Journal of Traditional and Complementary Medicine (2016), https://dx.doi.org/10.1016/j.jtcme.2016.02.002
6. Gupta PD. Pharmacogenetics, pharmacogenomics and ayurgenomics for personalized medicine: a paradigm shift. Indian J Pharm Sci. 2015 Mar-Apr;77(2):135-41.
7. Prasher B, Gibson G, Mukerji M. Genomic insights into ayurvedic and western approaches to personalized medicine. J Genet. 2016 Mar;95(1):209-28.
8. Rotti H, Mallya S, Kabekkodu SP, et al. DNA methylation analysis of phenotype specific stratified Indian population. J Transl Med. 2015 May 8;13:151.
9. Govindaraj P, Nizamuddin S, Sharath A, et al. Genome-wide analysis correlates Ayurveda Prakriti. Sci Rep. 2015 Oct 29;5:15786.
10. Prasher B, Negi S, Aggarwal S, et al. Whole genome expression and biochemical correlates of extreme constitutional types defined in Ayurveda. J Transl Med. 2008 Sep 9;6:48.
11. Mahalle, N. P., Kulkarni, M. V., Pendse, N. M. & Naik, S. S. Association of constitutional type of Ayurveda with cardiovascular risk factors, inflammatory markers and insulin resistance. J. Ayurveda Integr. Med. 3, 150–157 (2012).
12. DuBroff R, Lad V, Murray-Krezan C. A Prospective Trial of Ayurveda for Coronary Heart Disease: A Pilot Study. Altern Ther Health Med. 2015 Sep-Oct;21(5):52-62.
13. Rasmussen LB, Mikkelsen K, Haugen M, et al. Treatment of fibromyalgia at the Maharishi Ayurveda Health Centre in Norway. A six-month follow-up study. Clin Exp Rheumatol. 2009 Sep-Oct;27(5 Suppl 56):S46-50.
14. Patel KB, Patel M, Mehta CS, Gupta S, Kessler CS. Ayurvedic management of ulcerative colitis–a non-randomized observational clinical study. Forsch Komplementmed. 2013;20(2):144-7.
15. Banerjee S, Debnath P, Debnath PK. Ayurnutrigenomics: Ayurveda-inspired personalized nutrition from inception to evidence. J Tradit Complement Med. 2015 Mar 24;5(4):228-33.

MIGUEL TORIBIO-MATEAS
Further reading – Part 1
1. Chow, H. M. & Herrup, K. (2015) Genomic integrity and the ageing brain. Nat Rev Neurosci, 16(11) pp. 672-84.
2. St Laurent, G., 3rd, Hammell, N. & Mccaffrey, T. A. (2010) A LINE-1 component to human aging: do LINE elements exact a longevity cost for evolutionary advantage? Mech Ageing Dev, 131(5) pp. 299-305.
3. Ames, B. N., Atamna, H. & Killilea, D. W. (2005) Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging. Mol Aspects Med, 26(4-5) pp. 363-78.
4. Hernandez-Aguilera, A., Rull, A., Rodriguez-Gallego, E., Riera-Borrull, M., Luciano-Mateo, F., Camps, J., Menendez, J. A. & Joven, J. (2013) Mitochondrial dysfunction: a basic mechanism in inflammation-related non-communicable diseases and therapeutic opportunities. Mediators Inflamm, 2013pp. 135698.
5. Meramat, A., Rajab, N. F., Shahar, S. & Sharif, R. (2015) Cognitive impairment, genomic instability and trace elements. J Nutr Health Aging, 19(1) pp. 48-57.

MARK HOUSTON – Mercury

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2. (2000) Committee on the Toxicological Effects of Methylmercury, Board on Environmental Studies and Toxicology, Commission on Life Sciences. Toxicological effects of methylmercury. National Research Council, Washington, DC.
3. Magos L (1997) Physiology and toxicology of mercury. Met Ions BiolSyst 34: 321-370.
4. Clarkson TW, Magos L, Myers GJ (2003) The toxicology of mercury-current exposures and clinical manifestations. N Engl J Med 349: 1731-1737.
5. Guallar E, Sanz-Gallardo MI, van’t Veer P, Bode P, Aro A, et al. (2002) Mercury, fish oils, and the risk of myocardial infarction.N Engl J Med 347: 1747-1754.
6. Weinhold B (2004) Environmental cardiology: getting to the heart of the matter.Environ Health Perspect 112: A880-887.
7. Bhatnagar A (2006) Environmental cardiology: studying mechanistic links between pollution and heart disease.Circ Res 99: 692-705.
8. (2012)CERCLA Priority List of Hazardous Substances.
9. Ahlqwist M, Bengtsson C, Lapidus L, Gergdahl IA, Schütz A (1999) Serum mercury concentration in relation to survival, symptoms, and diseases: results from the prospective population study of women in Gothenburg, Sweden.ActaOdontolScand 57: 168-174.
10. Bergdahl IA, Schütz A, Ahlqwist M, Bengtsson C, Lapidus L, et al. (1998) Methylmercury and inorganic mercury in serum–correlation to fish consumption and dental amalgam in a cohort of women born in 1922.Environ Res 77: 20-24.
11. Salonen JT, Seppänen K, Nyyssönen K, Korpela H, Kauhanen J, et al. (1995) Intake of mercury from fish, lipid peroxidation, and the risk of myocardial infarction and coronary, cardiovascular, and any death in eastern Finnish men.Circulation 91: 645-655.
12. Yoshizawa K, Rimm EB, Morris JS, Spate VL, Hsieh CC, et al. (2002) Mercury and the risk of coronary heart disease in men.N Engl J Med 347: 1755-1760.
13. Chmielnicka J, Bem EM, Kaszubski P (1983) Organ and subcellular distribution of cadmium in rats exposed to cadmium, mercury, and selenium. Environ Res 31: 266-272.
14. Komsta-Szumska E, Chmielnicka J (1983) Effect of zinc, cadmium or copper on mercury distribution in rat tissues.ToxicolLett 17: 349-354.
15. International Programme on Chemical Safety (IPCS) (1990)Methylmercury. Environmental Health Criteria 101. Geneva: World Health Organization, USA.
16. Salonen JT, Seppänen K, Lakka TA, Salonen R, Kaplan GA (2000) Mercury accumulation and accelerated progression of carotid atherosclerosis: a population-based prospective 4-year follow-up study in men in eastern Finland.Atherosclerosis 148: 265-273.
17. Skoczyska A, Poreba R, Steinmentz-Beck A, Martynowicz H, Affelska-Jercha A, et al. (2009) The dependence between urinary mercury concentration and carotid arterial intima-media thickness in workers occupationally exposed to mercury vapour. Int J Occup Med Environ Health 22: 135-142.
18. Parízek J, Ostádalová I (1967) The protective effect of small amounts of selenite in sublimate intoxication.Experientia 23: 142-143.
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20. Ganther HE, Sunde ML (1974) Effect of tuna fish and selenium on the toxicity of methylmercury: a progress report. J Food Sci 39:1-5.
21. Stoewsand GS, Bache CA, Lisk DJ (1974) Dietary selenium protection of methylmercury intoxication of Japanese quail.Bull Environ ContamToxicol 11: 152-156.
22. Sumino K, Yamamoto R, Kitamura S (1977) A role of selenium against methylmercury toxicity.Nature 268: 73-74.

23. Singhal RK, Anderson ME, Meister A (1987) Glutathione, a first line of defense against cadmium toxicity. FASEB J 1: 220-223.
24. Seppänen K, Kantola M, Laatikainen R, Nyyssönen K, Valkonen VP, et al. (2000) Effect of supplementation with organic selenium on mercury status as measured by mercury in pubic hair.J Trace Elem Med Biol 14: 84-87.

25. Lund BO, Miller DM, Woods JS (1993) Studies on Hg(II)-induced H2O2 formation and oxidative stress in vivo and in vitro in rat kidney mitochondria.BiochemPharmacol 45: 2017-2024.
26. Shenker BJ, Guo TL, Shapiro IM (1998) Low-level methylmercury exposure causes human T-cells to undergo apoptosis: evidence of mitochondrial dysfunction.Environ Res 77: 149-159.

27. Jansson G, Harms-Ringdahl M (1993) Stimulating effects of mercuric- and silver ions on the superoxide anion production in human polymorphonuclear leukocytes.Free Radic Res Commun 18: 87-98.

28. Clarkson TW (1997) The toxicology of mercury.Crit Rev Clin Lab Sci 34: 369-403.

29. Insug O, Datar S, Koch CJ, Shapiro IM, Shenker BJ (1997) Mercuric compounds inhibit human monocyte function by inducing apoptosis: evidence for formation of reactive oxygen species, development of mitochondrial membrane permeability transition and loss of reductive reserve. Toxicology 124:211-224.

30. Wiggers GA, Pecanha FM, Briones AM, Perez-Giron JV, Miguel M, et al. (2008) Low mercury concentrations cause oxidative stress and endothelial dysfunction in conductance and resistance arteries. Am J Physiol Heart CircPhysiol 295: 1033-1043.

31. Kobal AB, Horvat M, Prezelj M, Briski AS, Krsnik M, et al. (2004) The impact of long-term past exposure to elemental mercury on antioxidative capacity and lipid peroxidation in mercury miners.J Trace Elem Med Biol 17: 261-274.

32. Park ST, Lim KT, Chung YT, Kim SU (1996) Methylmercury-induced neurotoxicity in cerebral neuron culture is blocked by antioxidants and NMDA receptor antagonists.Neurotoxicology 17: 37-45.

33. Miller DM, Lund BO, Woods JS (1991) Reactivity of Hg(II) with superoxide: evidence for the catalytic dismutation of superoxide by Hg(II).J BiochemToxicol 6: 293-298.

34. Naganuma A, Koyama Y, Imura N (1980) Behavior of methylmercury in mammalian erythrocytes.ToxicolApplPharmacol 54: 405-410.

35. Cuvin-Aralar ML, Furness RW (1991) Mercury and selenium interaction: a review.Ecotoxicol Environ Saf 21: 348-364.

36. Rungby J, Ernst E (1992) Experimentally induced lipid peroxidation after exposure to chromium, mercury or silver: interactions with carbon tetrachloride.PharmacolToxicol 70: 205-207.

37. Lin TH, Huang YL, Huang SF (1996) Lipid peroxidation in liver of rats administrated with methyl mercuric chloride.Biol Trace Elem Res 54: 33-41.

38. Wierzbicki R, Prazanowski M, Michalska M, Krajewska U, Mielicki WP (2002) Disorders in blood coagulation in humans occupationally exposed to mercuric vapors. J Trace Elem Exp Med 15:21-29.

39. Kishimoto T, Oguri T, Abe M, Kajitani H, Tada M (1995) Inhibitory effect of methylmercury on migration and tube formation by cultured human vascular endothelial cells.Arch Toxicol 69: 357-361.

40. Lu KP, Zhao SH, Wang DS (1990) The stimulatory effect of heavy metal cations on proliferation of aortic smooth muscle cells.Sci China B 33: 303-310.

41. Gonzalvo MC, Gil F, Hernández AF, Villanueva E, Pla A (1997) Inhibition of paraoxonase activity in human liver microsomes by exposure to EDTA, metals and mercurials.ChemBiol Interact 105: 169-179.

42. Salonen JT, Malin R, Tuomainen TP, Nyyssönen K, Lakka TA, et al. (1999) Polymorphism in high density lipoprotein paraoxonase gene and risk of acute myocardial infarction in men: prospective nested case-control study.BMJ 319: 487-489.

43. Boffetta P, Sällsten G, Garcia-Gómez M, Pompe-Kirn V, Zaridze D, et al. (2001) Mortality from cardiovascular diseases and exposure to inorganic mercury.Occup Environ Med 58: 461-466.

44. Torres AD, Rai AN, Hardiek ML (2000) Mercury intoxication and arterial hypertension: report of two patients and review of the literature.Pediatrics 105: E34.

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46. Wojciechowski J, Kowalski W (1975) Cardiac and aortic lesions in chronic experimental poisoning with mercury vapors.Pol Med SciHist Bull 15: 255-260.

47. Rissanen T, Voutilainen S, Nyyssonen K, Lakka TA, Salonen JT (2000) Fish oil-derived fatty acids, docosahexaenoic acid and docosapentaenoic acid, and the risk of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study. Circulation 102:2677-2679.

48. Virtanen JK, Voutilainen S, Rissanen TH, Mursu J, Tuomainen TP, et al. (2005) Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland.ArteriosclerThrombVascBiol 25: 228-233.

49. Kobal AB, Flisar Z, Miklavcic V, Dizdarević T, Sesek-Briski A (2000) Renal function in miners intermittently exposed to elemental mercury vapour.ArhHigRadaToksikol 51: 369-380.

50. Connor WE (2000) Importance of n-3 fatty acids in health and disease.Am J ClinNutr 71: 171S-5S.

51. Burr ML, Fehily AM, Gilbert JF, Rogers S, Holliday RM, et al. (1989) Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART).Lancet 2: 757-761.

52. (1999) GISSI-Prevenzione Investigators (GruppoItaliano per lo Studio dellaSopravvivenzanell’Infartomiocardico). Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 354:447-455.

53. Marckmann P, Grønbaek M (1999) Fish consumption and coronary heart disease mortality. A systematic review of prospective cohort studies.Eur J ClinNutr 53: 585-590.

54. MacIntosh DL, Williams PL, Hunter DJ, Sampson LA, Morris SC, et al. (1997) Evaluation of a food frequency questionnaire-food composition approach for estimating dietary intake of inorganic arsenic and methylmercury. Cancer Epidemiol Biomarkers Prev 6:1043-1050.

55. Garland M, Morris JS, Rosner BA, Stampfer MJ, Spate VL, et al. (1993) Toenail trace element levels as biomarkers: reproducibility over a 6-year period.Cancer Epidemiol Biomarkers Prev 2: 493-497.

56. Mazerik JN, Mikkilineni H, Kuppusamy VA, Steinhour E, Peltz A, et al. (2007) Mercury activates phospholipase a(2) and induces formation of arachidonic Acid metabolites in vascular endothelial cells.ToxicolMech Methods 17: 541-557.

57. Mazerik JN, Hagele T, Sherwani S, Ciapala V, Butler S, et al. (2007) Phospholipase A2 activation regulates cytotoxicity of methylmercury in vascular endothelial cells.Int J Toxicol 26: 553-569.

58. Hagele TJ, Mazerik JN, Gregory A, Kaufman B, Magalang U, et al. (2007) Mercury activates vascular endothelial cell phospholipase D through thiols and oxidative stress.Int J Toxicol 26: 57-69.

59. Peltz A, Sherwani SI, Kotha SR, Mazerik JN, O’Connor Butler ES, et al. (2009) Calcium and calmodulin regulate mercury-induced phospholipase D activation in vascular endothelial cells.Int J Toxicol 28: 190-206.

60. Wiggers GA, Peçanha FM, Briones AM, Pérez-Girón JV, Miguel M, et al. (2008) Low mercury concentrations cause oxidative stress and endothelial dysfunction in conductance and resistance arteries.Am J Physiol Heart CircPhysiol 295: H1033-1033H1043.

61. Al-Saleh I, Shinwari N, Mashhour A, Mohamed Gel-D, Ghosh MA, et al. (2006) Cadmium and mercury levels in Saudi women and its possible relationship with hypertension.Biol Trace Elem Res 112: 13-29.

62. Fillion M, Mergler D, Sousa Passos CJ, Larribe F, Lemire M, et al. (2006) A preliminary study of mercury exposure and blood pressure in the Brazilian Amazon.Environ Health 5: 29.

63. Bautista LE, Stein JH, Morgan BJ, Stanton N, Young T, et al. (2009) Association of blood and hair mercury with blood pressure and vascular reactivity.WMJ 108: 250-252.

64. Valera B, Dewailly E, Poirier P (2009) Environmental mercury exposure and blood pressure among Nunavik Inuit adults.Hypertension 54: 981-986.

65. Yorifuji T, Tsuda T, Kashima S, Takao S, Harada M (2010) Long-term exposure to methylmercury and its effects on hypertension in Minamata.Environ Res 110: 40-46.

66. Vupputuri S, Longnecker MP, Daniels JL, Guo X, Sandler DP (2005) Blood mercury level and blood pressure among US women: results from the National Health and Nutrition Examination Survey 1999-2000.Environ Res 97: 195-200.

67. Moszczyski P (2006) [Mercury and the risk of coronary heart disease].PrzeglLek 63 Suppl 7: 84-87.

68. Virtanen JK, Rissanen TH, Voutilainen S, Tuomainen TP (2007) Mercury as a risk factor for cardiovascular diseases.J NutrBiochem 18: 75-85.

69. Wennberg M, Strömberg U, Bergdahl IA, Jansson JH, Kauhanen J, et al. (2012) Myocardial infarction in relation to mercury and fatty acids from fish: a risk-benefit analysis based on pooled Finnish and Swedish data in men.Am J ClinNutr 96: 706-713.

70. Virtanen JK, Laukkanen JA, Mursu J, Voutilainen S, Tuomainen TP (2012) Serum long-chain n-3 polyunsaturated fatty acids, mercury, and risk of sudden cardiac death in men: a prospective population-based study.PLoS One 7: e41046.

71. Mozaffarian D, Shi P, Morris JS, Spiegelman D, Grandjean P, et al. (2011) Mercury exposure and risk of cardiovascular disease in two U.S. cohorts. N Engl J Med 364: 1116-1125.

72. Kim DS, Lee EH, Yu SD, Cha JH, Ahn SC (2005) [Heavy metal as risk factor of cardiovascular disease–an analysis of blood lead and urinary mercury].J Prev Med Public Health 38: 401-407.

73. Smith KM, Barraj LM, Kantor M, Sahyoun NR (2009) Relationship between fish intake, n-3 fatty acids, mercury and risk markers of CHD (National Health and Nutrition Examination Survey 1999-2002).Public Health Nutr 12: 1261-1269.

74. Skoczyska A, Jedrejko M, Martynowicz H, Poreba R, Affelska-Jercha A, et al. (2010) [The cardiovascular risk in chemical factory workers exposed to mercury vapor].Med Pr 61: 381-391.

75. Wennberg M, Bergdahl IA, Stegmayr B, Hallmans G, Lundh T, et al. (2007) Fish intake, mercury, long-chain n-3 polyunsaturated fatty acids and risk of stroke in northern Sweden.Br J Nutr 98: 1038-1045.
76. Lim KM, Kim S, Kim K, Jang WH, Bae ON, et al. (2010) Low- level mercury can enhance procoagulant activity of erythrocytes: a new contributing factor for mercury-related thrombotic disease. Environ Health Perspect. 118:928-935.

77. Pedersen EB, Jørgensen ME, Pedersen MB, Siggaard C, Sørensen TB, et al. (2005) Relationship between mercury in blood and 24-h ambulatory blood pressure in Greenlanders and Danes.Am J Hypertens 18: 612-618.

78. García Gómez M, Boffetta P, Caballero Klink JD, Español S, Gómez Quintana J (2007) [Cardiovascular mortality in mercury miners].Med Clin (Barc) 128: 766-771.

79. Choi AL, Weihe P, Budtz-Jørgensen E, Jørgensen PJ, Salonen JT, et al. (2009) Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men.Environ Health Perspect 117: 367-372.

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EFAs REVIEW
O. van de Rest, Y. Wang, L. L. Barnes, C. Tangney, D. A. Bennett, M. C. Morris. APOE 4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline. Neurology, 2016; DOI: 10.1212/WNL.0000000000002719
Jerome Sarris, Jenifer Murphy, David Mischoulon, George I. Papakostas, Maurizio Fava, Michael Berk, Chee H. Ng. Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses. American Journal of Psychiatry, 2016; appi.ajp.2016.1 DOI: 10.1176/appi.ajp.2016.15091228

Adrian Raine, Rose A. Cheney, Ringo Ho, Jill Portnoy, Jianghong Liu, Liana Soyfer, Joseph Hibbeln, Therese S. Richmond. Nutritional supplementation to reduce child aggression: a randomized, stratified, single-blind, factorial trial. Journal of Child Psychology and Psychiatry, 2016; DOI: 10.1111/jcpp.12565
Adrian Raine, Jill Portnoy, Jianghong Liu, Tashneem Mahoomed, Joseph R. Hibbeln. Reduction in behavior problems with omega-3 supplementation in children aged 8-16 years: a randomized, double-blind, placebo-controlled, stratified, parallel-group trial. Journal of Child Psychology and Psychiatry, 2015; 56 (5): 509 DOI: 10.1111/jcpp.12314

Qingying Meng, Zhe Ying, Emily Noble, Yuqi Zhao, Rahul Agrawal, Andrew Mikhail, Yumei Zhuang, Ethika Tyagi, Qing Zhang, Jae-Hyung Lee, Marco Morselli, Luz Orozco, Weilong Guo, Tina M. Kilts, Jun Zhu, Bin Zhang, Matteo Pellegrini, Xinshu Xiao, Marian F. Young, Fernando Gomez-Pinilla, Xia Yang. Systems Nutrigenomics Reveals Brain Gene Networks Linking Metabolic and Brain Disorders. EBioMedicine, 2016; DOI: 10.1016/j.ebiom.2016.04.008
RESEARCH UPDATE
Nathan F. Johnson, Brian T. Gold, Alison L. Bailey, Jody L. Clasey, Jonathan G. Hakun, Matthew White, Doug E. Long, David K. Powell. Cardiorespiratory fitness modifies the relationship between myocardial function and cerebral blood flow in older adults. NeuroImage, 2016; 131: 126 DOI: 10.1016/j.neuroimage.2015.05.063
Vittori Gouveia Luciana de Almeida, Cardoso Carolina Alves, de Oliveira Glaucia Maria Moraes, Rosa Glorimar, and Moreira Annie Seixas Bello. Journal of Medicinal Food. April 2016, 19(4): 337-345. doi:10.1089/jmf.2015.0075. Published in Volume: 19 Issue 4: April 13, 2016

David K. Cole, Anna M. Bulek, Garry Dolton, Andrea J. Schauenberg, Barbara Szomolay, William Rittase, Andrew Trimby, Prithiviraj Jothikumar, Anna Fuller, Ania Skowera, Jamie Rossjohn, Cheng Zhu, John J. Miles, Mark Peakman, Linda Wooldridge, Pierre J. Rizkallah, Andrew K. Sewell. Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. Journal of Clinical Investigation, 2016; DOI: 10.1172/JCI85679.
Robert I. Richards, Sarah A. Robertson, Louise V. O’Keefe, Dani Fornarino, Andrew Scott, Michael Lardelli, Bernhard T. Baune. The Enemy within: Innate Surveillance-Mediated Cell Death, the Common Mechanism of Neurodegenerative Disease. Frontiers in Neuroscience, 2016; 10 DOI: 10.3389/fnins.2016.00193
G. Hagen, T. Wisløff, I. S. Kristiansen. The predicted lifetime costs and health consequences of calcium and vitamin D supplementation for fracture prevention—the impact of cardiovascular effects. Osteoporosis International, 2016; 27 (6): 2089 DOI: 10.1007/s00198-016-3495-9
Mingzhan Xue, Martin O Weickert, Sheharyar Qureshi, Ngianga-Bakwin Kandala, Attia Anwar, Molly Waldron, Alaa Shafie, David Messenger, Mark Fowler, Gail Jenkins, Naila Rabbani, Paul J. Thornalley. Improved glycemic control and vascular function in overweight and obese subjects by glyoxalase 1 inducer formulation. Diabetes, 2016; db160153 DOI: 10.2337/db16-0153
Julia K. Goodrich, Emily R. Davenport, Michelle Beaumont, Matthew A. Jackson, Rob Knight, Carole Ober, Tim D. Spector, Jordana T. Bell, Andrew G. Clark, Ruth E. Ley. Genetic Determinants of the Gut Microbiome in UK Twins. Cell Host & Microbe, 2016; 19 (5): 731 DOI: 10.1016/j.chom.2016.04.017

May 2016

***IHCAN May 2016 REFERENCES***

OSTEOPOROSIS
J. Paccou et al. Ischemic heart disease is associated with lower cortical volumetric bone mineral density of distal radius. Osteoporosis International
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Elizabeth M. Curtis, Robert van der Velde, Rebecca J. Moon, Joop P.W. van den Bergh, Piet Geusens, Frank de Vries, Tjeerd P. van Staa, Cyrus Cooper, Nicholas C. Harvey. Epidemiology of fractures in the United Kingdom 1988–2012: Variation with age, sex, geography, ethnicity and socioeconomic status. Bone, 2016; 87: 19 DOI: 10.1016/j.bone.2016.03.006.

Stenson WF, Newberry R, Lorenz R, Baldus C, Civitelli R. Increased prevalence of celiac disease and need for routine screening among patients with osteoporosis. Archives of Internal Medicine; vol. 165, pp. 393-399, Feb. 28, 2005. doi: 10.1001/archinte.165.4.393.

Osteoporosis Associated with Neutralizing Autoantibodies against Osteoprotegerin
Philip L. Riches, M.R.C.P., Euan McRorie, F.R.C.P., William D. Fraser, Ph.D., F.R.C.Path., Catherine Determann, B.Med.Sci., Rob van’t Hof, Ph.D., and Stuart H. Ralston, M.D.
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Bone Metabolism in Celiac Disease
Chiara Zanchi, MD Grazia Di Leo, MD Luca Ronfani, MD, Stefano Martelossi, MD, Tarcisio Not, MD, Alessandro Ventura, MD Journal of Pediatrics, August 2008, Volume 153, Issue 2, Pages 262–265, DOI: https://dx.doi.org/10.1016/j.jpeds.2008.03.003.
Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity.
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Kohn et al. A cardiovascular phenotype in warfarin-resistant Vkorc1 mutant rats☆. Artery Research, 2008; 2 (4): 138 DOI: 10.1016/j.artres.2008.09.002

Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
Knapen MH, Braam LA, Drummen NE, Bekers O, Hoeks AP, Vermeer C1. Thromb Haemost. 2015 May;113(5):1135-44. doi: 10.1160/TH14-08-0675. Epub 2015 Feb 19.

Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. M. H. J. Knapen, N. E. Drummen, E. Smit, C. Vermeer, E. Theuwissen . Osteoporosis International September 2013, Volume 24, Issue 9, pp 2499-2507. First online: 23 March 2013

April 2016

Bruno R da Costa, Stephan Reichenbach, Noah Keller, Linda Nartey, Simon Wandel, Peter Jüni, Sven Trelle. Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. The Lancet, 2016; DOI: 10.1016/S0140-6736(16)30002-2

ALZHEIMER’S 1,2. Prince MA, Emiliano; Guerchet, Maëlenn; Prina, Matthew. 2014; World Alzheimer Report 2014 United Kingdom: Alzheimer’s Disease International.

3. James BD, Leurgans SE, Hebert LE, Scherr PA, Yaffe K and Bennett DA. Contribution of Alzheimer disease to mortality in the United States. Neurology. 2014; 82:1045-1050. 4. https://www.alzheimersresearchuk.org/dementia-is-leading-cause-of-death-for-women-in-england-and-wales/ 5. Shriver M. A Woman’s Nation Takes on Alzheimer’s. 2010; New York, USA: Alzheimer’s Association. 6. 2014 Alzheimer’s Disease Facts and Figures. Special Report on Women and Alzheimer’s Disease. USA: Alzheimer’s Association, 2014; pp. 1-80. 7. www.alzheimers.org.uk/site/scripts/press_article.php?pressReleaseID=605 8. Bredesen D. Reversal of cognitive decline: A novel therapeutic program. 2014; Los Angeles: Impact Journals. 9. https://www.scientificamerican.com/article/why-alzheimer-s-drugs-keep-failing/ 10. Bredesen D. Reversal of cognitive decline: A novel therapeutic program. 2014; Los Angeles. Impact Journals.

ME/CFS * #MEAction petition https://my.meaction.net/petitions/pace-trial-needs-review-now * The PACE Lancet paper https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)60096-2/fulltext * Open letter to The Lancet from 42 scientists and doctors https://www.virology.ws/2016/02/10/open-letter-lancet-again/ * Dr David Tuller’s article on the PACE trial https://www.virology.ws/2015/10/21/trial-by-error-i/

BEN BROWN

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Trovato A, et al. Redox modulation of cellular stress response and lipoxin A4 expression by Coriolus versicolor in rat brain: Relevance to Alzheimer’s disease pathogenesis. Neurotoxicology. 2015 Oct 1. pii: S0161-813X(15)00165-5. doi: 10.1016/j.neuro.2015.09.012. (epub version). Recent Pat Inflamm Allergy Drug Discov. 2012 Jan;6(1):78-87. Efficacy of Yun Zhi (Coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis. Eliza WL1, Fai CK, Chung LP.

ALLERGIES and INTOLERANCES Perkin MR, Logan K, et al. Randomized trial of the early introduction of allergenic foods in breastfed infants. New England Journal of Medicine, 2016 DOI 10.1056/NEJMoa1514210 [Epub ahead of print] Jung-Hwan Kim, Eun-Ji Jeun, Chun-Pyo Hong, Seong-Hoon Kim, Min Seong Jang, Eun-Jung Lee, Sook Jin Moon, Chang Ho Yun, Sin-Hyeog Im, Seok-Geun Jeong, Beom-Young Park, Kyong-Tai Kim, Ju-Young Seoh, Yoon-Keun Kim, Sung-Jong Oh, Jun-Sang Ham, Bo-Gie Yang, Myoung Ho Jang. Extracellular vesicle–derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression. Journal of Allergy and Clinical Immunology, 2016; 137 (2): 507 DOI: 10.1016/j.jaci.2015.08.016 Roberto Berni Canani, Naseer Sangwan, Andrew T Stefka, Rita Nocerino, Lorella Paparo, Rosita Aitoro, Antonio Calignano, Aly A Khan, Jack A Gilbert, Cathryn R Nagler. Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants. The ISME Journal, 2015; DOI: 10.1038/ismej.2015.151

Matthieu Deschamps, Guillaume Laval, Maud Fagny, Yuval Itan, Laurent Abel, Jean-Laurent Casanova, Etienne Patin, Lluis Quintana-Murci. Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes. The American Journal of Human Genetics, 2016; 98 (1): 5 DOI: 10.1016/j.ajhg.2015.11.014 Michael Dannemann, Aida M. Andrés, Janet Kelso. Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors. The American Journal of Human Genetics, 2016; 98 (1): 22 DOI: 10.1016/j.ajhg.2015.11.015 Tabea Brick, Yvonne Schober, Christian Böcking, Juha Pekkanen, Jon Genuneit, Georg Loss, Jean-Charles Dalphin, Josef Riedler, Roger Lauener, Wolfgang Andreas Nockher, Harald Renz, Outi Vaarala, Charlotte Braun-Fahrländer, Erika von Mutius, Markus Johannes Ege, Petra Ina Pfefferle. ω-3 fatty acids contribute to the asthma-protective effect of unprocessed cow’s milk. Journal of Allergy and Clinical Immunology, 2016; DOI: 10.1016/j.jaci.2015.10.042 RESEARCH YihQ is a sulfoquinovosidase that cleaves sulfoquinovosyl diacylglyceride sulfolipids Gaetano Speciale, Yi Jin, Gideon J Davies, Spencer J Williams & Ethan D Goddard-Borger Nature Chemical Biology 2016, 12, 215–217. doi:10.1038/nchembio.2023. Witawas Handee, Xiaobo Li, Kevin W. Hall, Xiexiong Deng, Pan Li, Christoph Benning, Barry L. Williams, Min-Hao Kuo. An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast. PLOS Genetics, 2016; 12 (2): e1005878 DOI: 10.1371/journal.pgen.1005878 Loucks, Eric B.; Gilman, Stephen E.; Britton, Willoughby B.; Gutman, Roee; Eaton, Charles B.; Buka, Stephen L. Associations of Mindfulness with Glucose Regulation and Diabetes. American Journal of Health Behavior, February 2016 DOI: 10.5993/AJHB.40.2.11 Samuel E. Marsh, Edsel M. Abud, Anita Lakatos, Alborz Karimzadeh, Stephen T. Yeung, Hayk Davtyan, Gianna M. Fote, Lydia Lau, Jason G. Weinger, Thomas E. Lane, Matthew A. Inlay, Wayne W. Poon, Mathew Blurton-Jones. The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function. Proceedings of the National Academy of Sciences, 2016; 201525466 DOI: 10.1073/pnas.1525466113 Sean M. Grimmond et al. Genomic analyses identify molecular subtypes of pancreatic cancer. Nature, 2016; DOI: 10.1038/nature16965 Influence of Obesity on Breast Density Reduction by Omega-3 Fatty Acids: Evidence from a Randomized Clinical Trial. Sandhu N, Schetter SE, Liao J, Hartman TJ, Richie JP, McGinley J, Thompson HJ, Prokopczyk B, DuBrock C, Signori C, Hamilton C, Calcagnotto A, Trushin N, Aliaga C, Demers LM, El-Bayoumy K, Manni A. Cancer Prev Res (Phila). 2015 Dec 29. [Epub ahead of print] Aubrey J Cunnington, Kathleen Sim, Aniko Deierl, J Simon Kroll, Eimear Brannigan, Jonathan Darby. “Vaginal seeding” of infants born by caesarean section. BMJ, 2016; i227 DOI: 10.1136/bmj.i227 Molly K. Gibson, Bin Wang, Sara Ahmadi, Carey-Ann D. Burnham, Phillip I. Tarr, Barbara B. Warner, Gautam Dantas. Developmental dynamics of the preterm infant gut microbiota and antibiotic resistome. Nature Microbiology, 2016; 16024 DOI: 10.1038/nmicrobiol.2016.24

March 2016

NEWS Jorge Vas, Koldo Santos-Rey, Reyes Navarro-Pablo, Manuela Modesto, Inmaculada Aguilar, M Ángeles Campos, José Francisco Aguilar-Velasco, Milagrosa Romero, Patricia Párraga, Vanesa Hervás, Olalla Santamaría, Carmen Márquez-Zurita, Francisco Rivas-Ruiz. Acupuncture for fibromyalgia in primary care: a randomised controlled trial. Acupuncture in Medicine, 2016; acupmed-2015-010950 DOI: 10.1136/acupmed-2015-010950.
Ferric C. Fang, Anthony Bowen and Arturo Casadevall. NIH Peer Review Percentile Scores are Poorly Predictive of Grant Productivity. eLife, 2016, DOI: https://dx.doi.org/10.7554/eLife.13323.

Sung Ryeol Park, Ashootosh Tripathi, Jianfeng Wu, Pamela J. Schultz, Isaiah Yim, Thomas J. McQuade, Fengan Yu, Carl-Johan Arevang, Abraham Y. Mensah, Giselle Tamayo-Castillo, Chuanwu Xi, David H. Sherman. Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway. Nature Communications, 2016; 7: 10710 DOI: 10.1038/ncomms10710. Charbonneau et al. Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition. Cell, 2016 DOI: 10.1016/j.cell.2016.01.024. L. Claxton, M. Taylor, E. Kay. Oral health promotion: the economic benefits to the NHS of increased use of sugarfree gum in the UK. BDJ, 2016; 220 (3): 121 DOI: 10.1038/sj.bdj.2016.94.

“Adding fluoride to water supply may have no benefit, say experts”. Haroon Siddique. The Guardian, Friday 25 December 2015: https://www.theguardian.com/society/2015/dec/25/fluoride-water-supply-benefit-unproved-tooth-decay.

M. Schwarzer, K. Makki, G. Storelli, I. Machuca-Gayet, D. Srutkova, P. Hermanova, M. E. Martino, S. Balmand, T. Hudcovic, A. Heddi, J. Rieusset, H. Kozakova, H. Vidal, F. Leulier. Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition. Science, 2016; 351 (6275): 854 DOI: 10.1126/science.aad8588. Associated references: Lactobacillus plantarum promotes Drosophila systemic growth by modulating hormonal signals through TOR-dependent nutrient sensing, Gilles Storelli, Arnaud Defaye, Berra Erkosar, Pascal Hols, Julien Royet, François Leulier, Cell Metabolism (2011) 14(3):403-414; and Pathogen Virulence Impedes Mutualist-Mediated Enhancement of Host Juvenile Growth via Inhibition of Protein Digestion. Berra Erkosar, Gilles Storelli, Mélanie Mitchell, Loan Bozonnet, Noémie Bozonnet, François Leulier. Cell Host and Microbe (2015) 18(4):445-55. Ana Isabel Ribeiro, Elias Teixeira Krainski, Marilia Sá Carvalho, Maria de Fátima de Pina. Where do people live longer and shorter lives? An ecological study of old-age survival across 4404 small areas from 18 European countries. Journal of Epidemiology and Community Health, 2016; jech-2015-206827 DOI: 10.1136/jech-2015-206827 . Cynthia Owsley, Gerald McGwin, Mark E. Clark, Gregory R. Jackson, Michael A. Callahan, Lanning B. Kline, C. Douglas Witherspoon, Christine A. Curcio. Delayed Rod-Mediated Dark Adaptation Is a Functional Biomarker for Incident Early Age-Related Macular Degeneration. Ophthalmology, 2016; 123 (2): 344 DOI: 10.1016/j.ophtha.2015.09.041. Line Pedersen et al. Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution. Cell Metabolism, February 2016 DOI: 10.1016/j.cmet.2016.01.011 Anil K. Singh, Sadiq Umar, Sharayah Riegsecker, Mukesh Chourasia, Salahuddin Ahmed. Regulation of Transforming Growth Factor β-Activated Kinase Activation by Epigallocatechin-3-Gallate in Rheumatoid Arthritis Synovial Fibroblasts: Suppression of K63-Linked Autoubiquitination of Tumor Necrosis Factor Receptor-Associated Factor 6. Arthritis & Rheumatology, 2016; 68 (2): 347 DOI: 10.1002/art.39447

GUT HEALTH and PROBIOTICS Julie Urban, Daniel J. Fergus, Amy M. Savage, Megan Ehlers, Holly L. Menninger, Robert R. Dunn, Julie E. Horvath. The effect of habitual and experimental antiperspirant and deodorant product use on the armpit microbiome. PeerJ, 2016; 4: e1605 DOI: 10.7717/peerj.1605 Shuichi Tonomura, Masafumi Ihara, Tomohiro Kawano, Tomotaka Tanaka, Yoshinori Okuno, Satoshi Saito, Robert P. Friedland, Nagato Kuriyama, Ryota Nomura, Yoshiyuki Watanabe, Kazuhiko Nakano, Kazunori Toyoda, Kazuyuki Nagatsuka. Intracerebral hemorrhage and deep microbleeds associated with cnm-positive Streptococcus mutans; a hospital cohort study. Scientific Reports, 2016; 6: 20074 DOI: 10.1038/srep20074 Hongjie Li, Yanyan Qi, Heinrich Jasper. Preventing Age-Related Decline of Gut Compartmentalization Limits Microbiota Dysbiosis and Extends Lifespan. Cell Host & Microbe, 2016; 19 (2): 240 DOI: 10.1016/j.chom.2016.01.008 Vinegar Treatment Prevents the Development of Murine Experimental Colitis via Inhibition of Inflammation and Apoptosis Fengge Shen†, Jiaxuan Feng§, Xinhui Wang†, Zhimin Qi†, Xiaochen Shi†, Yanan An†, Qiaoli Zhang†, Chao Wang†, Mingyuan Liu†#, Bo Liu*†, and Lu Yu*† J. Agric. Food Chem., 2016, 64 (5), pp 1111–1121, DOI: 10.1021/acs.jafc.5b05415

FUNCTIONAL MEDICINE – BEN BROWN

1. Costenbader KH, et al. Genes, epigenetic regulation and environmental factors: which is the most relevant in developing autoimmune diseases? Autoimmun Rev. 2012 Jun;11(8):604-9. 2. Ashan H et al. Oxygen free radicals and systemic autoimmunity. Clin Exp Immunol. 2003 Mar;131(3):398-404. 3. Kurien BT, Scofield RH. Autoimmunity and oxidatively modified autoantigens. Autoimmun Rev. 2008 Jul;7(7):567-73. 4. Perl A. Oxidative stress in the pathology and treatment of systemic lupus erythematosus. Nat Rev Rheumatol. 2013 Nov;9(11):674-86. 5. Wang G, Pierangeli SS, Papalardo E, Ansari GA, Khan MF. Markers of oxidative and nitrosative stress in systemic lupus erythematosus: correlation with disease activity. Arthritis Rheum. 2010 Jul;62(7):2064-72. 6. Ortona E, Margutti P, Matarrese P, Franconi F, Malorni W. Redox state, cell death and autoimmune diseases: a gender perspective. Autoimmun Rev. 2008 Jul;7(7):579-84. 7. Costenbader KH, Kang JH, Karlson EW. Antioxidant intake and risks of rheumatoid arthritis and systemic lupus erythematosus in women. Am J Epidemiol. 2010;172:205–216. 8. Tam LS, et al. Effects of vitamins C and E on oxidative stress markers and endothelial function in patients with systemic lupus erythematosus: A double-blind, placebo-controlled pilot study. J Rheumatol 2005;32:275–282. 9. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev. 2012 Mar 14;3:CD007176. 10. Harris C, Hansen JM. Oxidative stress, thiols, and redox profiles. Methods Mol Biol. 2012;889:325-46. 11. Perricone C, De Carolis C, Perricone R. Glutathione: a key player in autoimmunity. Autoimmun Rev. 2009 Jul;8(8):697-701. 12. Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr. 2015 Mar;54(2):251-63. 13. Allen J, Bradley RD. Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. J Altern Complement Med. 2011 Sep;17(9):827-33. 14. Lai ZW, Hanczko R, Bonilla E, et al. N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2012 Sep;64(9):2937-46. 15. Lai Z-W, Hanczko R, Bonilla E, et al. N-acetylcysteine reduces disease activity by blocking mTOR in T cells of lupus patients. Arthritis and Rheumatism. 2012;64:2937–2946. 16. Doherty E, Oaks Z, Perl A. Increased mitochondrial electron transport chain activity at complex I is regulated by N-acetylcysteine in lymphocytes of patients with systemic lupus erythematosus. Antioxid Redox Signal. 2014 Jul 1;21(1):56-65. 17. Perl A, Hanczko R, Lai ZW, Oaks Z, Kelly R, Borsuk R, Asara JM, Phillips PE. Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin. Metabolomics. 2015;11(5):1157-1174. 18. Li M, Gao W, Ma J, Zhu Y, Li X. Early-stage lupus nephritis treated with N-acetylcysteine: A report of two cases. Exp Ther Med. 2015 Aug;10(2):689-692. Epub 2015 May 21. 19. Khalili M, Azimi A, Izadi V, et al. Does lipoic acid consumption affect the cytokine profile in multiple sclerosis patients: a double-blind, placebo-controlled, randomized clinical trial. Neuroimmunomodulation. 2014;21(6):291-6. 20. Chandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res. 2012 Nov;26(11):1719-25. 21. Samsami-Kor M, Daryani NE, Asl PR, Hekmatdoost A. Anti-Inflammatory Effects of Resveratrol in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo controlled Pilot Study. Arch Med Res. 2015 May;46(4):280-5.

AGEING Deirdre A. Robertson, Rose Anne Kenny. Negative perceptions of ageing modify the association between frailty and cognitive function in older adults. Personality and Individual Differences, 2015; DOI: 10.1016/j.paid.2015.12.010

NUTRIGENOMICS – ANNE PEMBERTON 1. Klinghardt, D. (2013) kryptopyrroluria (Pyroluria) – Lyme Induced Autism. https://www.youtube.com/watch?v=THZhANfFnyY

2. Banerjee R, Zou CG (January 2005). “Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein”. Archives of Biochemistry and Biophysics 433 (1): 144–56. doi:10.1016/j.abb.2004.08.037. PMID 15581573.

3. https://mthfr.net/forums/topic/sulphur-sensitivity/

4. Dahlhoff C, Desmarchelier C, Sailer M, Fürst RW, Haag A, et al. (2013) Hepatic Methionine Homeostasis Is Conserved in C57BL/6N Mice on High-Fat Diet Despite Major Changes in Hepatic One-Carbon Metabolism. PLoS ONE 8(3): e57387. doi: 10.1371/journal.pone.0057387

February 2016

NEWSGenotype, B-vitamin status, and androgens affect space flight–induced ophthalmic changes. January 2016 The FASEB Journal vol. 30 no. 1 141-148. Sara R. Zwart* et al.

doi: 10.1096/fj.15-278457.

NEWS – cancer

Vinay Prasad, Jeanne Lenzer, David H Newman. Why cancer screening has never been shown to “save lives”—and what we can do about it. BMJ, 2016; h6080 DOI: 10.1136/bmj.h6080

Gerd Gigerenzer. Full disclosure about cancer screening. BMJ, 2016; h6967 DOI: 10.1136/bmj.h6967

Substantial contribution of extrinsic risk factors to cancer development

Song Wu, Scott Powers, Wei Zhu & Yusuf A. Hannun.

Nature 529, 43–47, (07 January 2016)

doi:10.1038/nature16166).

Change the cancer conversation. The ‘war on cancer’ has run off course. Efforts must refocus on the best interests of patients, says Colin Macilwain.

01 April 2015: https://www.nature.com/news/change-the-cancer-conversation-1.17236. Nature 520, 7 (02 April 2015), doi:10.1038/520007a.

Lancet Oncology. Volume 16, No. 13, p1324–1334, October 2015

Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial

Dr Christophe Le Tourneau, MD ert al. DOI: https://dx.doi.org/10.1016/S1470-2045(15)00188-6.

Five Years of Cancer Drug Approvals, Innovation, Efficacy, and Costs

Sham Mailankody, MB BS1; Vinay Prasad, MD, MPH1

JAMA Oncol. 2015;1(4):539-540. doi:10.1001/jamaoncol.2015.0373.

BEN BROWN

Hou JK, Abraham B, El-Serag H. Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature. Am J Gastroenterol. 2011 Apr;106(4):563-73.
Lucendo AJ, De Rezende LC. Importance of nutrition in inflammatory bowel disease. World J Gastroenterol. 2009 May 7;15(17):2081-8.
Asakura H, Suzuki K, Kitahora T, Morizane T. Is there a link between food and intestinal microbes and the occurrence of Crohn’s disease and ulcerative colitis? J Gastroenterol Hepatol. 2008 Dec;23(12):1794-801.
Leone V, Chang EB, Devkota S. Diet, microbes, and host genetics: the perfect storm in inflammatory bowel diseases. J Gastroenterol. 2013 Mar;48(3):315-21. Free full-text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698420.
Nickerson KP, Chanin R, McDonald C. Deregulation of intestinal anti-microbial defense by the dietary additive, maltodextrin. Gut Microbes. 2015;6(1):78-83.
Nickerson KP, Homer CR, Kessler SP, et al. The dietary polysaccharide maltodextrin promotes Salmonella survival and mucosal colonization in mice. PLoS One. 2014 Jul 7;9(7):e101789. DOI: 10.1371/journal.pone.0101789.

Nickerson KP, McDonald C. Crohn’s disease-associated adherent-invasive Escherichia coli adhesion is enhanced by exposure to the ubiquitous dietary polysaccharide maltodextrin. PLoS One. 2012;7(12):e52132.
HAAS SV, HAAS MP. The treatment of celiac disease with the specific carbohydrate diet; report on 191 additional cases. Am J Gastroenterol. 1955 Apr;23(4):344-60.
Gottschall E. Breaking the Vicious Cycle: Intestinal Health Through Diet. Baltimore, Canada: Kirkton Press; 1987. https://www.breakingtheviciouscycle.info/home
Walters SS et al. Analysis of gut microbiome and diet modification in patients with Crohn’s disease. SOJ Microbiol Infect Dis 2014, 2 (3):1–13. Free full-text online: https://www.symbiosisonlinepublishing.com/microbiology-infectiousdiseases/microbiology-infectiousdiseases22.php.
Kakodkar S, Farooqui AJ, Mikolaitis SL, Mutlu EA. The Specific Carbohydrate Diet for Inflammatory Bowel Disease: A Case Series. J Acad Nutr Diet. 2015 Aug;115(8):1226-32.
Obih C, Wahbeh G, Lee D, Braly K, Giefer M, Shaffer ML, Nielson H, Suskind DL. Specific carbohydrate diet for pediatric inflammatory bowel disease in clinical practice within an academic IBD center. Nutrition. 2015 Nov 30. pii: S0899-9007(15)00389-5.
Suskind DL, Wahbeh G, Gregory N, Vendettuoli H, Christie D. Nutritional therapy in pediatric Crohn disease: the specific carbohydrate diet. J Pediatr Gastroenterol Nutr. 2014 Jan;58(1):87-91.
Khandalavala BN, Nirmalraj MC. Resolution of Severe Ulcerative Colitis with the Specific Carbohydrate Diet. Case Rep Gastroenterol. 2015 Aug 7;9(2):291-5.
Cohen SA, Gold BD, Oliva S, Lewis J, Stallworth A, Koch B, Eshee L, Mason D. Clinical and mucosal improvement with specific carbohydrate diet in pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2014 Oct;59(4):516-21. doi: 10.1097/MPG.0000000000000449.
Shepherd SJ, Lomer MC, Gibson PR. Short-chain carbohydrates and functional gastrointestinal disorders. Am J Gastroenterol. 2013 May;108(5):707-17.
Gearry RB, Irving PM, Barrett JS, Nathan DM, Shepherd SJ, Gibson PR. Reduction of dietary poorly absorbed short-chain carbohydrates (FODMAPs) improves abdominal symptoms in patients with inflammatory bowel disease-a pilot study. J Crohns Colitis. 2009 Feb;3(1):8-14.
Nucera G, Gabrielli M, Lupascu A, Lauritano EC, Santoliquido A, Cremonini F, Cammarota G, Tondi P, Pola P, Gasbarrini G, Gasbarrini A. Abnormal breath tests to lactose, fructose and sorbitol in irritable bowel syndrome may be explained by small intestinal bacterial overgrowth. Aliment Pharmacol Ther. 2005 Jun 1;21(11):1391-5.
Khan MA, Nusrat S, Khan MI, Nawras A, Bielefeldt K. Low-FODMAP Diet for Irritable Bowel Syndrome: Is It Ready for Prime Time? Dig Dis Sci. 2015 May;60(5):1169-77.
Chiba M, Yoshida T, Komatsu M. From low-residue diets to plant-based diets in inflammatory bowel disease. Dig Dis Sci. 2014 Dec;59(12):3129-30.
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EVOMED JAMIE RICHARDS

Nature Communications 2013, 4, 1860, doi:10.1038/ncomms2814. The genomics of selection in dogs and the parallel evolution between dogs and humans. Guo-dong Wang et al.

NEW RELEASES

CurraNZ

Fat oxidation

New Zealand Blackcurrant Improves Performance and Fat Oxidation in Cyclists, Willems ME1, Myers SD, Blacker S, Cook MD. European Journal of Applied Physiology, 2015

Diabetes/Obesity

Evaluation of Beneficial Metabolic Effects of Berries in High-Fat Fed C57BL/6J Mice. Lovisa Heyman,1 Ulrika Axling,1 Narda Blanco,2 Olov Sterner,2 Cecilia Holm,1 and Karin Berger1. Journal of Nutrition and Metabolism Volume 2014 (2014), Article ID 403041, https://dx.doi.org/10.1155/2014/403041 Published 14 January 2014

Postprandial glucose, insulin, and free fatty acid responses to sucrose consumed with blackcurrants and lingonberries in healthy women.Törrönen R1, Kolehmainen M, Sarkkinen E, Mykkänen H, Niskanen L. Am J Clin Nutr. 2012 Sep;96(3):527-33. doi: 10.3945/ajcn.112.042184. Epub 2012 Aug 1.

Anthocyanin increases adiponectin secretion and protects against diabetes-related endothelial dysfunction. Liu Y, Li D, Zhang Y, Sun R, Xia M. Am J Physiol Endocrinol Metab. 2014;306(8):E975-88.

Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes. Tsuda T, Ueno Y, Aoki H et al. Biochem Biophys Res Commun. 2004;316(1):149-57.

High Fat Meal Increase of IL-17 is Prevented by Ingestion of Fruit Juice Drink in Healthy Overweight Subjects. Peluso, IlariaRaguzzini, Anna Villano, Debora V Cesqui, EleonoraToti, ElisabettaCatasta, GiovinaSerafini, Mauro. CURRENT PHARMACEUTICAL DESIGN 2012, 18:

Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expres-sion in diabetic mice. Sasaki R, Nishimura N, Hoshino H, Isa Y, Kadowaki M, Ichi T, Tanaka A, Nishiumi S, Fukuda I, Ashida H, Horio F, Tsuda, T. (2007). Biochem Pharmacol. 2007; 74(11):1619-27

Polyphenol-rich blackcurrant extract prevents inflammation in diet-induced obese mice. Benn T1, Kim B1, Park YK1, Wegner CJ1, Harness E1, Nam TG2, Kim DO2, Lee JS3, Lee JY4. J Nutr Biochem. 2014 Oct;25(10):1019-25. doi: 10.1016/j.jnutbio.2014.05.008. Epub 2014 Jun 13.

Evaluation of Beneficial Metabolic Effects of Berries in High-Fat Fed C57BL/6J Mice. Heyman L1, Axling U1, Blanco N2, Sterner O2, Holm C1, Berger K1. J Nutr Metab. 2014;2014:403041. doi: 10.1155/2014/403041. Epub 2014 Jan 14.

Berry components inhibit α-glucosidase in vitro: synergies between acarbose and polyphenols from black currant and rowanber-ry.Boath AS1, Stewart D, McDougall GJ. Food Chem. 2012 Dec 1;135(3):929-36. doi: 10.1016/j.foodchem.2012.06.065. Epub 2012 Jul 1.

Polyphenol-rich extract from blackcurrant pomace attenuates the intestinal tract and serum lipid changes induced by a high-fat diet in rabbits. Jurgoński A1, Juśkiewicz J, Zduńczyk Z, Matusevicius P, Kołodziejczyk K. Eur J Nutr. 2014 Dec;53(8):1603-13. doi: 10.1007/s00394-014-0665-4. Epub 2014 Feb 6.

Cholesterol

Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects. Qin Y1, Xia M, Ma J, Hao Y, Liu J, Mou H, Cao L, Ling W. Am J Clin Nutr. 2009 Sep;90(3):485-92. doi: 10.3945/ ajcn.2009.27814. Epub 2009 Jul 29.

Polyphenol-rich blackcurrant extract exerts hypocholesterolaemic and hypoglycaemic effects in mice fed a diet containing high fat and cholesterol. Benn T1, Kim B1, Park YK1, Yang Y1, Pham TX1, Ku CS1, Farruggia C1, Harness E1, Smyth JA2, Lee JY1. Br J Nutr. 2015 Apr 22:1-7. [Epub ahead of print]

Antioxidants

Cyanidin and cyanidin 3-O-beta-D-glucoside as DNA cleavage protectors and antioxidants. Acquaviva R, Russo A, Galvano F, et al. Cell Biol Toxicol. 2003;19(4):243–252.

Isolation and free-radical scavenging proper-ties of cyanidin 3-O-glycosides from the fruits of Ribes A. Delazar, L. Khodaie, J. Afshar,L. Nahar and S. D. Sarker, biebersteinii Berl,Acta. Pharm., 2010, 60, 1–11.

Anthocyanins from black currants (Ribes nigrum L.), R. Slimestad and H. Solheim, J. Agric.Food Chem., 2002, 50, 3228–3231.

The health benefits of blackcurrants Ashwin Gopalan,a Sharon C. Reuben,a Shamima Ahmed,a Altaf S. Darvesh,a Judit Hohmannb and Anupam Bishayee*c et al J Med Food. 2012 Dec;15(12):1045-50. doi: 10.1089/jmf.2011.0316. Epub 2012 Jun 27

Vasodilation

Upregulation of endothelial nitric oxide synthase by cyanidin-3-glucoside, a typical anthocyanin pigment. Xu JW, Ikeda K, Yamori Y (2004). Hy-pertension 44, 217-222.

Effect of black currant anthocyanins on the activation of endothelial nitric oxide synthase (eNOS) in vitro in human endothelial cells. Edirisinghe I1, Banaszewski K, Cappozzo J, McCarthy D, Burton-Freeman BM. J Agric Food Chem. 2011 Aug 24;59(16):8616-24. doi: 10.1021/jf201116y. Epub 2011 Jul 28.

Effects of blackcurrant anthocyanin intake on peripheral muscle circulation during typing work in humans, H. Matsumoto, E. Takenami, K. Iwasaki-Kurashige, T. Osada, T. Katsumura and T.Hamaoka, Eur. J. Appl. Physiol., 2005, 94, 36–45.

Brain health

Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer’s disease. Vepsäläinen S1, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall GJ, Stewart D, Haapasalo A, Karjalainen RO, Tanila H, Hiltunen M. J Nutr Biochem. 2013 Jan;24(1):360-70. doi: 10.1016/j.jnutbio.2012.07.006. Epub 2012 Sep 17.

Acute supplementation with blackcurrant extracts modulates cognitive functioning and inhibits monoamine oxidase-B in healthy young adults Anthony W. Watsona, b, , , Crystal F. Haskell-Ramsaya, David O. Kennedya, Janine M. Cooneyb, Tania Trowerb, Arjan Scheepens. Journal of Functional Foods, Volume 17, August 2015, Pages 524-539

High fat meal increase of IL-17 is prevented by ingestion of fruit juice drink in healthy overweight subjects. Peluso I1, Raguzzini A, Villano DV, Cesqui E, Toti E, Catasta G, Serafini M. Curr Pharm Des. 2012;18(1):85-90.

Effects of anthocyanins and other phenolics of boysenberry and blackcurrant as inhibitors of oxidative stress and damage to cellular DNA in SH-SY5Y and HL-60 cells. Dilip Ghosh1,*, Tony K McGhie2, Jingli Zhang1, Aselle Adaim1 and Margot Skinner1. Journal of the Science of Food and Agriculture Volume 86, Issue 5, pages 678–686, 15 April 2006 Article first published online: 23 JAN 2006 DOI: 10.1002/jsfa.2409

Cytoprotective effects of anthocyanins and other phenolic fractions of Boysenberry and blackcurrant on dopamine and amyloid-induced oxidative stress in transfected COS-7 cells Dilip Ghosh, Tony K McGhie, Derek R Fisher, James A Joseph.Journal of the Science of Food and Agriculture

The impact of fruit flavonoids on memory and cognition. Spencer JP. Br J Nutr. 440 2010;104 Suppl 3; S40-7.

Neuroinflammation: modulation by flavonoids and mechanisms of action. Spencer JP1, Vafeiadou K, Williams RJ, Vauzour D. Mol Aspects Med. 2012 Feb;33(1):83-97. doi: 10.1016/j.mam.2011.10.016. Epub 2011 Nov 15.

The neuroprotective potential of flavonoids: a multiplicity of effects. Vauzour D1, Vafeiadou K, Rodriguez-Mateos A, Rendeiro C, Spencer JP Genes Nutr. 2008 Dec;3(3-4):115-26. doi: 10.1007/s12263-008-0091-4.Brain Res. 2014 Mar 25;1555:60-77. doi: 10.1016/j.brainres.2014.01.047. Epub 2014 Feb 3.

Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson’s disease. Strathearn KE1, Yousef GG2, Grace MH2, Roy SL1, Tambe MA1, Ferruzzi MG3, Wu QL4, Simon JE4, Lila MA2, Rochet JC5.

Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. Vauzour D. Oxid Med Cell Longev. 2012;2012:914273. doi: 10.1155/2012/914273. Epub 2012 Jun .

Beneficial effects of berry fruit polyphenols on neuronal and behavioural aging. Lau, F. C., Shukitt-Hale,B. and Joseph, J. A. (2006) J. Sci. Food Agric. 86, 2251 – 2255.

Effect of flavonoids on learning, memory and neurocognitive performance: relevance and potential implications for Alzheimer’s disease pathophysiology. Vauzour D. J Sci Food Agric. 2014 Apr;94(6):1042-56. doi: 10.1002/jsfa.6473. Epub 2013 Dec 12.

Cardio-protection

Effect of blackcurrant anthocyanins on the activation of endothelial nitric oxide synthase (eNOS) in vitro in human endothelial cells, I.Edirisinghe, K.Banaszewski, J.Cappozzo, D.McCarthy and B.M.Burton-Freeman, J.AGRIC.FOOD CHEM., 2011, 59, 8616-8624

Purified Anthocyanin Supplementation Improves Endothelial Function via NO-cGMP activation in Hypercholesterolemic Individuals. Zhu, Yanna Xia, Min Yang, Yan Liu, FengqiongLi, ZhongxiaHao, YuantaMi, Mantia Jin, TianruLing, Wenhua, CLINICAL CHEMISTRY 2011, 57 1524-1533.

Error! Hyperlink reference not valid., M.Rosenblat, N.Volkova, J.Attias, R.Mahamid and M.Aviram, FOOD FUNCT., 2010, 1, 99-109.

Anthocyanins in Cardiovascular Disease. Wallace. T.C. ADVANCES IN NUTRITION 2008. 2:1-7

Bioavailability and molecular activities of anthocyanins as modulators of endothelial function. Speciale A, Cimino F, Saija A, Canali R, Virgili F. Genes Nutr. 2014;9(4):404.

Delphinidin inhibits VEGF induced-mitochondrial biogenesis and Akt activation in endothelial cells. Duluc L1, Jacques C2, Soleti R3, Andriant¬sitohaina R4, Simard G5. Int J Biochem Cell Biol. 2014 Aug;53:9-14. doi: 10.1016/j.biocel.2014.03.030. Epub 2014 Apr 30.

Anthocyanin increases adiponectin secretion and protects against diabetes-related endothelial dysfunction. Liu Y, Li D, Zhang Y, Sun R, Xia M. Am J Physiol Endocrinol Metab. 2014;306(8):E975-88.

The endothelial plasma membrane transporter bilitranslocase mediates rat aortic vasodilation induced by anthocyanins. Ziberna L, Lunder M, Tramer F, Drevenšek G, Passamonti S. Nutr Metab Cardiovasc Dis. 2013;23(1):68-74.

Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease. Dalgård C1, Nielsen F, Morrow JD, Enghusen-Poulsen H, Jonung T, Hørder M, de Maat MP. Br J Nutr. 2009 Jan;101(2):263-9. doi: 10.1017/S0007114508995660. Epub 2008 May 28.

Intake of specific flavonoids and risk of acute myocardial infarction in Italy. Tavani, A., Spertini, L., Bosetti, C., Parpinel, M., Gnagnarella,P., Bravi, F., Peterson, J., Dwyer, J., Lagiou, P., Negri, E.and La Vecchia, C. (2006) Public HealthNutr. 9, 369 – 374.

RESEARCHJae H. Kang, Walter C. Willett, Bernard A. Rosner, Emmanuel Buys, Janey L. Wiggs, Louis R. Pasquale. Association of Dietary Nitrate Intake With Primary Open-Angle Glaucoma. JAMA Ophthalmology, 2016; 1 DOI: 10.1001/jamaophthalmol.2015.5601

St-Onge MP, Roberts A, Shechter A, Choudhury AR. Fiber and saturated fat are associated with sleep arousals and slow wave sleep. J Clin Sleep Med, 2016;12(1):19%u201324. DOI: 10.5664/jcsm.5384

Kelli A. Lytle, Donald B. Jump. Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible? PLOS ONE, 2016; 11 (1): e0146942 DOI: 10.1371/journal.pone.0146942

Erica D. Sonnenburg, Samuel A. Smits, Mikhail Tikhonov, Steven K. Higginbottom, Ned S. Wingreen, Justin L. Sonnenburg. Diet-induced extinctions in the gut microbiota compound over generations. Nature, 2016; 529 (7585): 212 DOI: 10.1038/nature16504

January 2016
December 2015

WELCOME

GBD 2013 Risk Factor Collaborators. Global, regional, and national comparative

risk assessment of 79 behavioural, environmental and occupational, and

metabolic risks or clusters of risks in 188 countries,1990–2013: a systematic

analysis for the Global Burden of Disease Study 2013.

Lancet. Published Online September 11, 2015https://dx.doi.org/10.1016/S0140-6736(15)00128-2

NEWSHomeopathyThere is no scientific case for homeopathy: the debate is over

Edzard Ernst: The Guardian, Thursday 12 March 2015: https://www.theguardian.com/commentisfree/2015/mar/12/no-scientific-case-homeopathy-remedies-pharmacists-placebos

House of Commons Science and Technology Committee – Fourth ReportEvidence Check 2: Homeopathy https://www.publications.parliament.uk/pa/cm200910/cmselect/cmsctech/45/4502.htmJeff Blandwww.jeffreybland.com.

YouTube video: https://www.youtube.com/watch?v=i8gbXjf6DbM

Update on Medical Practices That Should Be Questioned in 2015

Daniel J. Morgan, MD, MS1,2,3; Sanket S. Dhruva, MD4,5; Scott M. Wright, MD6; Deborah Korenstein, MD7

1Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore2Department of Hospital Epidemiology, Veterans Affairs Maryland Health Care System, Baltimore3Center for Disease Dynamics, Economics & Policy, Washington, DC4Robert Wood Johnson Foundation Clinical Scholars Program, Yale University School of Medicine, New Haven, Connecticut5Department of Veterans Affairs, West Haven, Connecticut6Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland7Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York

JAMA Intern Med. Published online November 09, 2015. doi:10.1001/jamainternmed.2015.5614).

Choosing Wisely in the UK: the Academy of Medical Royal Colleges’ initiative to reduce the harms of too much medicine

BMJ 2015; 350 doi: https://dx.doi.org/10.1136/bmj.h2308 (Published 12 May 2015)

FUNCTIONAL MEDICINE MASTERCLASS

BEN BROWN

1. Murray PJ, Wivell G, Denton E. Breast cancer screening and diagnosis in the 21st century within the UK. Post Reprod Health. 2015 Sep;21(3):105-11.

Independent UK Panel on Breast Cancer Screening. The benefits and harms of breast cancer screening: an independent review. Lancet 2012; 380: 1778–1786.
3. Cavalieri EL, Rogan EG. Unbalanced metabolism of endogenous estrogens in the etiology and prevention of human cancer. J Steroid Biochem Mol Biol. 2011 Jul;125(3-5):169-80.4. Sepkovic DW, Bradlow HL. Estrogen hydroxylation–the good and the bad. Ann N Y Acad Sci. 2009 Feb;1155:57-67. 5. Sepkovic DW, Bradlow HL. Estrogen hydroxylation–the good and the bad. Ann N Y Acad Sci. 2009 Feb;1155:57-67.6. Fowke JH, Longcope C, Hebert JR. Brassica vegetable consumption shifts estrogen metabolism in healthy postmenopausal women. Cancer Epidemiol Biomarkers Prev. 2000 Aug;9(8):773-9. 7. Reding KW, Atkinson C, Westerlind KC, Stanczyk F, Bowles EJ, Yong M, Newton KM, Lampe JW. Fruit intake associated with urinary estrogen metabolites in healthy premenopausal women. Open J Prev Med. 2012 Feb 23;2(1).8. Reding KW, Zahid M, Cavalieri E, Rogan EG, Raccor BS, Atkinson C, Yong M, Newton KM, Lampe JW. Associations between Dietary Intake of Fruits and Vegetables in relation to Urinary Estrogen DNA Adduct Ratio. Open J Prev Med. 2014 Jun;4(6):429-437.

Muran PJ, Muran SY, Beseler CL, Cavalieri EL, Rogan EG, Zahid M. Breast health and reducing breast cancer risk: a functional medicine approach. J Altern Complement Med. 2015 Jun;21(6):321-6.

STRESS

Szyf, M.. DNA methylation properties: consequences for pharmacology. Trends Pharmacol Sci 15: 233-238.

Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):684-9.

Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide.

Ramchandani S1, MacLeod AR, Pinard M, von Hofe E, Szyf M.

Nature. 1999 Feb 18;397(6720):579-83.

A mammalian protein with specific demethylase activity for mCpG DNA.

Bhattacharya SK1, Ramchandani S, Cervoni N, Szyf M.

Lei Cao-Lei, Renaud Massart, Matthew J. Suderman, Ziv Machnes, Guillaume Elgbeili, David P. Laplante, Moshe Szyf, Suzanne King. DNA Methylation Signatures Triggered by Prenatal Maternal Stress Exposure to a Natural Disaster: Project Ice Storm. PLoS ONE, 2014; 9 (9): e107653 DOI: 10.1371/journal.pone.0107653.

J Nutr. 2002 Aug;132(8 Suppl):2333S-2335S.Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline. Niculescu MD1, Zeisel SH.

J Neurosci. 2005 Nov 23;25(47):11045-54. Free online at : https://www.jneurosci.org/content/25/47/11045.longReversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life.Weaver IC1, Champagne FA, Brown SE, Dymov S, Sharma S, Meaney MJ, Szyf M.

Brain Res. 2008 Oct 27;1237:12-24. doi: 10.1016/j.brainres.2008.07.074. Epub 2008 Jul 29. Diet and the epigenetic (re)programming of phenotypic differences in behavior.

McGowan PO1, Meaney MJ, Szyf M.

Free online at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC295101

OPINION

Chew EY, et al. Effect of omega-3 fatty acids, lutein/zeaxanthin, or other nutrient supplementation on cognitive function: The AREDS2 randomized clinical trial. JAMA 2015;314:791-801. https://jama.jamanetwork.com/article.aspx?articleid=2429713Science 18 September 2015:Vol. 349 no. 6254 pp. 1343-1347DOI: 10.1126/science.aab2319

Greenlandic Inuit show genetic signatures of diet and climate adaptation

Matteo Fumagalli et al

RESEARCHEfficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Elderly: A Randomized, Double-Blind, Placebo-Controlled Trial

Liu, Guosonga; d; * | Weinger, Jason G.a | Lu, Zhong-Linb | Xue, Fengc | Sadeghpour, Safaa

Journal of Alzheimer’s Disease, vol. Preprint, no. Preprint, pp. 1-19, 2015

David Just and Brian Wansink (2015). Fast Food, Soft Drink, and Candy Intake is Unrelated to Body Mass Index for 95% of American Adults. Obesity Science & Practice, forthcoming. onlinelibrary.wiley.com/journal/10.1002/(ISSN)2055-2238

Ayelet Sivan, Leticia Corrales, Nathaniel Hubert, Jason B. Williams, Keston Aquino-Michaels, Zachary M. Earley, Franco W. Benyamin, Yuk Man Lei, Bana Jabri, Maria-Luisa Alegre, Eugene B. Chang, and Thomas F. Gajewski. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy. Science, November 2015 DOI: 10.1126/science.aac4255

Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseases

Bidisha Paul et al. Clinical Epigenetics 2015, 7:112

(doi: 10.1186/s13148-015-0144-7)

Matzkin, K. Suslavich, E. J. Curry. Lyme Disease Presenting as a Spontaneous Knee Effusion. Journal of the American Academy of Orthopaedic Surgeons, 2015; 23 (11): 674 DOI: 10.5435/JAAOS-D-14-00388
Carol Kumamoto et al. Manipulation of Host Diet To Reduce Gastrointestinal Colonization by the Opportunistic Pathogen Candida albicans. mSphere, November 2015 DOI: 10.1128/mSphere.00020-15

Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study Ulla Uusitalo, et al for the TEDDY Study Group

JAMA Pediatr. Published online November 09, 2015. doi:10.1001/jamapediatrics.2015.2757

Efficacy of Bright Light Treatment, Fluoxetine, and the Combination in Patients With Nonseasonal Major Depressive Disorder: A Randomized Clinical Trial.Raymond W. Lam, et al.

JAMA Psychiatry. Published online November 18, 2015.

(doi:10.1001/jamapsychiatry.2015.2235).

A. Kenfield, J. L. Batista, J. L. Jahn, M. K. Downer, E. L. Van Blarigan, H. D. Sesso, E. L. Giovannucci, M. J. Stampfer, J. M. Chan. Development and Application of a Lifestyle Score for Prevention of Lethal Prostate Cancer. JNCI Journal of the National Cancer Institute, 2015; 108 (3): djv329 DOI: 10.1093/jnci/djv329

November 2015
October 2015

NEWS

Peng Li, Stephanie C. Tjen-A-Looi, Ling Cheng, Dongmei Liu, Jeannette Painovich, Sivarama Vinjamury, John C. Longhurst. Long-Lasting Reduction of Blood Pressure by Electroacupuncture in Patients with Hypertension: Randomized Controlled Trial. Medical Acupuncture, 2015; 27 (4): 253 DOI: 10.1089/acu.2015.1106

BMC Biol. 2014; 12: 8. Published online 2013 Jan 31. doi: 10.1186/1741-7007-12-8

PMCID: PMC3909335. Cancer, metabolism, fructose, artificial sweeteners, and going cold turkey on sugar. Lewis C Cantley.

doi: 10.1186/1741-7007-12-8

Peng Li, Stephanie C. Tjen-A-Looi, Ling Cheng, Dongmei Liu, Jeannette Painovich, Sivarama Vinjamury, John C. Longhurst. Long-Lasting Reduction of Blood Pressure by Electroacupuncture in Patients with Hypertension: Randomized Controlled Trial. Medical Acupuncture, 2015; 27 (4): 253 DOI: 10.1089/acu.2015.1106

Rebecca I. Clark, Anna Salazar, Ryuichi Yamada, Sorel Fitz-Gibbon, Marco Morselli, Jeanette Alcaraz, Anil Rana, Michael Rera, Matteo Pellegrini, William W. Ja, David W. Walker. Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality. Cell Reports, 2015; 12 (10): 1656 DOI: 10.1016/j.celrep.2015.08.004.

BEN BROWN – Inflammation

1. Bested AC, Logan AC, Selhub EM. Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: Part I – autointoxication revisited. Gut Pathog. 2013 Mar 18;5(1):5. 2. Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, Neyrinck AM, Fava F, Tuohy KM, Chabo C, Waget A, Delmée E, Cousin B, Sulpice T, Chamontin B, Ferrières J, Tanti JF, Gibson GR, Casteilla L, Delzenne NM, Alessi MC, Burcelin R. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007 Jul;56(7):1761-72.3. Egger G, Dixon J. Beyond obesity and lifestyle: a review of 21st century chronic disease determinants. Biomed Res Int. 2014;2014:731685.4. Cani PD, Delzenne NM. The gut microbiome as therapeutic target. Pharmacol Ther. 2011 May;130(2):202-12.5. Amar J, Burcelin R, Ruidavets JB, Cani PD, Fauvel J, Alessi MC, Chamontin B, Ferriéres J. Energy intake is associated with endotoxemia in apparently healthy men. Am J Clin Nutr. 2008 May;87(5):1219-23.6. Ghanim H, Abuaysheh S, Sia CL, Korzeniewski K, Chaudhuri A, Fernandez-Real JM, Dandona P. Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance. Diabetes Care. 2009 Dec;32(12):2281-7

Pendyala S, Walker JM, Holt PR. A high-fat diet is associated with endotoxemia that originates from the gut. Gastroenterology. 2012 May;142(5):1100-1101.e2. doi: 10.1053/j.gastro.2012.01.034.
Xiao S, Fei N, Pang X, Shen J, Wang L, Zhang B, Zhang M, Zhang X, Zhang C, Li M, Sun L, Xue Z, Wang J, Feng J, Yan F, Zhao N, Liu J, Long W, Zhao L. A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome. FEMS Microbiol Ecol. 2014 Feb;87(2):357-67.
9. Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett. 2008 Dec;29(6):902-10.10. Albenberg LG, Wu GD. Diet and the intestinal microbiome: associations, functions, and implications for health and disease. Gastroenterology. 2014 May;146(6):1564-72.

Chassaing B, et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 2015 Mar 5;519(7541):92-6
12. David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA, Biddinger SB, Dutton RJ, Turnbaugh PJ. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014 Jan 23;505(7484):559-63.13. Dehghan P, Pourghassem Gargari B, Asghari Jafar-abadi M. Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized controlled clinical trial. Nutrition. 2014 Apr;30(4):418-23.14. Simon MC, Strassburger K, Nowotny B, Kolb H, Nowotny P, Burkart V, Zivehe F, Hwang JH, Stehle P, Pacini G, Hartmann B, Holst JJ, MacKenzie C, Bindels LB, Martinez I, Walter J, Henrich B, Schloot NC, Roden M. Intake of Lactobacillus reuteri Improves Incretin and Insulin Secretion in Glucose Tolerant Humans: A Proof of Concept. Diabetes Care. 2015 Jun 17. pii: dc142690. [Epub ahead of print]15. Sellmann C, Jin CJ, Degen C, De Bandt JP, Bergheim I. Oral Glutamine Supplementation Protects Female Mice from Nonalcoholic Steatohepatitis. J Nutr. 2015 Aug 5. pii: jn215517. [Epub ahead of print]16. de Souza AZ, Zambom AZ, Abboud KY, Reis SK, Tannihão F, Guadagnini D, Saad MJ, Prada PO. Oral supplementation with L-glutamine alters gut microbiota of obese and overweight adults: A pilot study. Nutrition. 2015 Jun;31(6):884-9.

Brimelow RE, et al. A Role for Whey-derived Lactoferrin and Immunoglobulins in the Attenuation of Obesity-related Inflammation and Disease? Crit Rev Food Sci Nutr. 2015 Jun 11:0. [Epub ahead of print]

Emma Lane – parasites

Crompton, D.W.T. 1999. How much human helminthiasis is there in the world? Journal of Parasitology 85(3): 397-403; The World Health Organization; and various additional published reviews

Journal of Parasitology 85:379-403 Dr. D.W.T. Crompton (Crompton, D.W.T. [1999How much human helminthiasis is there in the world?)

Gillespie S and Pearson R. Principles and Practice of Clinical Parasitology. John Wiley & Sons, Ltd. Chichester. ISBN: 0-471-97729-2. 2001

Leventhal R and Cheadle R. Medical Parasitology, A Self Instructional Text 6th Edition. F A Davis Company. Philadelphia. ISBN: 978-0-8036-2543-3. 2012.

Bush A, Fernandez J, Esch G and Seed J. Parasitism, The diversity and ecology of animal parasites. Cambridge University Press. Cambridge. ISBN: 0-521-66447-0. 2001.

Baron S. Medical Microbiology 4th Edition. University of Texas Medical Branch. Galveston. ISBN: 0-9631172-1-1. 1996

Mullin G. Integrative Gastroenterology. Oxford University Press. New York. ISBN 978-0-19537110-9. 2011.

Wright J and Lenard L. Why stomach acid is good for you. M. Evans and Company, Inc. New York. ISBN: 0-87131-931-4. 2001.

Pizzorno Jr J, Murray M and Joiner-Bey H. The Clinician’s Handbook of Natural Medicine 2nd Edition. Churchill Livingstone. Missouri. ISBN: 978-0-443-06723-5. 2008.

Liska D, Quinn S, Lukaczer D, Jones D and Lerman R. Clinical Nutrition, A Functional Approach. 2nd Edition. The Institute for Functional Medicine. Washington. ISBN: 978-0-9773713-2-7. 2006.

Lord R and Bralley J. Laboratory Evaluations for Integrative and Functional Medicine 2nd Edition. Genova Diagnostics. Duluth. ISBN: 978-0-9884322-0-8. 2012.

Lipski E. Digestive Wellness 4th Edition. McGraw Hill. New York. ISBN 978-0-07-166899-6. 2012.

The significance of bio-markers in the interpretation of comprehensive stool analysis results. By Omar M. Amin, B.Sc., M.Sc., Ph.D., USA Explore! Volume 20, Number 2, 2011

Detecting Microbes, By Omar M. Amin, B.Sc., M.Sc., Ph.D., USA, Chapter 15 of Optimal Digestive Heath – A Complete Guide, edited by Trent W Nichols, MD, and Nancy Faass, MSW MPH. Published by Healing Arts Press, Rochester Vermont Copyright 1999, 2005 by Nancy Faass and by Trent W Nichols, M.D.

Prevalence, Distribution, and Host Relationships of Cryptosporidium Parvum (Protozoa)
Infections in the United States, 2003-2005 © By Omar M. Amin, B.SC., M.SC., Ph.D., USA Explore! Volume 16, Number 1, 2006

The Epidemiology of Blastocystis horminis in the United States, By Omar M. Amin, B.Sc., M.Sc., Ph.D., USA, Research Journal of Parasitology 1 (1): 1-10, 2006

Prevalence, Distribution and Host Relationships of Cryptosporidium Parvum (Protozoa) Infections in the United States, 2003 – 2005 © By Omar M. Amin, B.SC., M.SC., Ph.D., USA . Explore! Volume 16, Number 1, 2006

RESEARCH

Mingguang He, Fan Xiang, Yangfa Zeng, Jincheng Mai, Qianyun Chen, Jian Zhang, Wayne Smith, Kathryn Rose, Ian G. Morgan. Effect of Time Spent Outdoors at School on the Development of Myopia Among Children in China. JAMA, 2015; 314 (11): 1142 DOI: 10.1001/jama.2015.10803

Michael X. Repka. Prevention of Myopia in Children. JAMA, 2015; 314 (11): 1137 DOI: 10.1001/jama.2015.10723

Logan NS, Davies LN, Mallen EA, Gilmartin B; Davies; Mallen; Gilmartin (April 2005). “Ametropia and ocular biometry in a U.K. university student population”. Optom Vis Sci 82 (4): 261–6. doi:10.1097/01.OPX.0000159358.71125.95. PMID 15829853.

Mokry LE, Ross S, Ahmad OS, Forgetta V, Smith GD, Leong A, et al. Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study. PLoS Med, 2015 DOI: 10.1371/journal.pmed.1001866

Ramagopalan SV, Heger A, Berlanga AJ, Maugeri NJ, Lincoln MR, Burrell A, Handunnetthi L, Handel AE, Disanto G, Orton S, Watson CT, Morahan JM, Giovannoni G, Ponting CP, Ebers GC, Knight JC. A ChIP-seq-defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution. Genome Research, 2010; DOI: 10.1101/gr.107920.110

McManus A et al (2015) Impact of prolonged sitting on vascular function in young girls. DOI: 10.1113/EP085355 https://onlinelibrary.wiley.com/doi/10.1113/EP085355/abstract

Cell Matbolism. Volume 22, Issue 2, p320–331, 4 August 2015. Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome

Saeed Shoaie et al. DOI: https://dx.doi.org/10.1016/j.cmet.2015.07.001

Tanya J Flynn, Murray Cadzow, Nicola Dalbeth, Peter B Jones, Lisa K Stamp, Jennie Harré Hindmarsh, Alwyn S Todd, Robert J Walker, Ruth Topless, Tony R Merriman. Positive association of tomato consumption with serum urate: support for tomato consumption as an anecdotal trigger of gout flares. BMC Musculoskeletal Disorders, 2015; 16 (1) DOI: 10.1186/s12891-015-0661-8

Paul S. Frenette et al. Neutrophil ageing is regulated by the microbiome. Nature, September 2015 DOI: 10.1038/nature15367.

S.A. Kim, H. Moon, K. Lee and M.S. Rhee. Bactericidal effects of triclosan in soap both in vitro and in vivo. Journal of Antimicrobial Chemotherapy, September 2015 DOI: 10.1093/jac/dkv275.

H. Moonaz, C. O. Bingham, L. Wissow, S. J. Bartlett. Yoga in Sedentary Adults with Arthritis: Effects of a Randomized Controlled Pragmatic Trial. The Journal of Rheumatology, 2015; 42 (7): 1194 DOI: 10.3899/jrheum.141129.

Liuyang Wang, Stefan H. Oehlers, Scott T. Espenschied, John F. Rawls, David M. Tobin, Dennis C. Ko. CPAG: software for leveraging pleiotropy in GWAS to reveal similarity between human traits links plasma fatty acids and intestinal inflammation. Genome Biology, 2015; 16 (1) DOI: 10.1186/s13059-015-0722-1

Estefanía Toledo, Jordi Salas-Salvadó, Carolina Donat-Vargas, Pilar Buil-Cosiales, Ramón Estruch, Emilio Ros, Dolores Corella, Montserrat Fitó, Frank B. Hu, Fernando Arós, Enrique Gómez-Gracia, Dora Romaguera, Manuel Ortega-Calvo, Lluís Serra-Majem, Xavier Pintó, Helmut Schröder, Josep Basora, José Vicente Sorlí, Mònica Bulló, Merce Serra-Mir, Miguel A. Martínez-González. Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial. JAMA Internal Medicine, 2015; 1 DOI: 10.1001/jamainternmed.2015.4838
S. Turner, R. G. Thomas, S. Craft, C. H. van Dyck, J. Mintzer, B. A. Reynolds, J. B. Brewer, R. A. Rissman, R. Raman, P. S. Aisen. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology, 2015; DOI: 10.1212/WNL.0000000000002035

September 2015

EN BROWN

1. Karell K, Louka AS, Moodie SJ, Ascher H, Clot F, Greco L, Ciclitira PJ, Sollid LM, Partanen J; European Genetics Cluster on Coeliac Disease. HLA types in coeliac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Coeliac Disease. Hum Immunol. 2003 Apr;64(4):469-77.2. Trynka G, Hunt KA, Bockett NA, et al. Dense genotyping identifies and localizes multiple common and rare variant association signals in coeliac disease. Nat Genet. 2011 Nov 6;43(12):1193-201.3. Lohi S, Mustalahti K, Kaukinen K, Laurila K, Collin P, Rissanen H, Lohi O, Bravi E, Gasparin M, Reunanen A, Mäki M. Increasing prevalence of coeliac disease over time. Aliment Pharmacol Ther. 2007 Nov 1;26(9):1217-25.4. Catassi C, Kryszak D, Bhatti B, Sturgeon C, Helzlsouer K, Clipp SL, Gelfond D, Puppa E, Sferruzza A, Fasano A. Natural history of coeliac disease autoimmunity in a USA cohort followed since 1974. Ann Med. 2010 Oct;42(7):530-8.5. West J, Fleming KM, Tata LJ, Card TR, Crooks CJ. Incidence and prevalence of coeliac disease and dermatitis herpetiformis in the UK over two decades: population-based study. Am J Gastroenterol. 2014 May;109(5):757-68.6. Kasarda DD. Can an increase in coeliac disease be attributed to an increase in the gluten content of wheat as a consequence of wheat breeding? J Agric Food Chem. 2013 Feb 13;61(6):1155-9.7. Freeman HJ. Coeliac disease: a disorder emerging from antiquity, its evolving classification and risk, and potential new treatment paradigms. Gut Liver. 2015 Jan;9(1):28-37.8. Størdal K, Haugen M, Brantsæter AL, Lundin KE, Stene LC. Association between maternal iron supplementation during pregnancy and risk of coeliac disease in children. Clin Gastroenterol Hepatol. 2014 Apr;12(4):624-31.e1-2.

Ludvigsson JF, Murray JA, Adams PC, et al. Does hemochromatosis predispose to coeliac disease? A study of 29,096 coeliac disease patients. Scand J Gastroenterol. 2013;48:176–182
10. Tanpowpong P, Obuch JC, Jiang H, McCarty CE, Katz AJ, Leffler DA, Kelly CP, Weir DC, Leichtner AM, Camargo CA Jr. Multicenter study on season of birth and coeliac disease: evidence for a new theoretical model of pathogenesis. J Pediatr. 2013 Mar;162(3):501-4.11. Ivarsson A, Hernell O, Nyström L, Persson LA. Children born in the summer have increased risk for coeliac disease. J Epidemiol Community Health. 2003 Jan;57(1):36-9.12. Lebwohl B, Green PH, Murray JA, Ludvigsson JF. Season of birth in a nationwide cohort of coeliac disease patients. Arch Dis Child. 2013 Jan;98(1):48-51.13. Tanpowpong P, Camargo CA. Early-life vitamin D deficiency and childhood-onset coeliac disease. Public Health Nutr. 2014 Apr;17(4):823-6.

Sandberg-Bennich S, Dahlquist G, Ka¨lle´n B. Coeliac disease is associated with intrauterine growth and neonatal infections. Acta Paediatr. 2002;91:30–33.
Myle´us A, Hernell O, Gothefors L, et al. Early infections are associated with increased risk for coeliac disease: an incident casereferent study. BMC Pediatr. 2012;19(12):194.
Riddle MS, Murray JA, Cash BD, Pimentel M, Porter CK. Pathogen-specific risk of coeliac disease following bacterial causes of foodborne illness: a retrospective cohort study. Dig Dis Sci. 2013 Nov;58(11):3242-5.
17. Keenan JI, Day AS. Risks for coeliac disease: bacteria make it three. Dig Dis Sci. 2013 Nov;58(11):3066-7.18. Lebwohl B, Ludvigsson JF, Green PH. The unfolding story of coeliac disease risk factors. Clin Gastroenterol Hepatol. 2014 Apr;12(4):632-

FATIGUE

M Hornig, G Gottschalk, D L Peterson, K K Knox, A F Schultz, M L Eddy, X Che, W I Lipkin. Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome. Molecular Psychiatry, 2015; DOI: 10.1038/mp.2015.29

Roumiana S. Boneva, Jin-Mann S. Lin, Elizabeth R. Unger. Early menopause and other gynecologic risk indicators for chronic fatigue syndrome in women. Menopause, 2015; 1 DOI: 10.1097/GME.0000000000000411

Mady Hornig, José G. Montoya, Nancy G. Klimas, Susan Levine, Donna Felsenstein, Lucinda Bateman, Daniel L. Peterson, C. Gunnar Gottschalk, Andrew F. Schultz, Xiaoyu Che, Meredith L. Eddy, Anthony L. Komaroff, W. Ian Lipkin. Distinct plasma immune signatures in ME/CFS are present early in the course of illness. Science Advances, 2015 DOI: 10.1126/sciadv.1400121Anne Pemberton

Bosque P. Vitamin B12 deficiency – Epidemiology. Medmerits [Internet]. 2014 [cited 2015 Aug 15]; Available from: https://www.medmerits.com/index.php/article/vitamin_b12_deficiency/P6
Healton EB, Savage DG, Brust JC, Garrett TJ, Lindenbaum J. Neurologic aspects of cobalamin deficiency. Medicine (Baltimore) [Internet]. 1991 Jul [cited 2015 Aug 15];70(4):229–45. Available from: https://www.ncbi.nlm.nih.gov/pubmed/1648656
Goringe A, Ellis R, McDowell I, et al. The limited value of methylmalonic acid, homocysteine and holotranscobalamin in the diagnosis of early B12 deficiency. Haematologica 2006;91:231-4.
Mitchell ES, Conus N, Kaput J. B vitamin polymorphisms and behavior: evidence of associations with neurodevelopment, depression, schizophrenia, bipolar disorder and cognitive decline. Neurosci Biobehav Rev [Internet]. 2014 Nov [cited 2015 Aug 15];47:307–20. Available from: https://www.sciencedirect.com/science/article/pii/S0149763414002048
NEW RELEASES

BMC Complement Altern Med. 2011; 11: 16.

Published online 2011 Feb 25. doi: 10.1186/1472-6882-11-16

PMCID: PMC3056848

Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses

Christian Krawitz,#

Global Information Hub on Integrated Medicine entry on elderberry: https://www.globinmed.com/index.php?option=com_content&view=article&id=83212:sambucus-nigra&catid=860:s#35

ANTIOXIDANTSUnraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits

Michael Ristow Nature Medicine 20, 709–711 (2014)

doi:10.1038/nm.3624

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

Michael Ristowa, b, , , Kim Zarsea Experimental Gerontology (doi:10.1038/nm.3624). Volume 45, Issue 6, June 2010, Pages 410–418

Cell Death and Differentiation (2015) 22, 377–388; doi:10.1038/cdd.2014.150; published online 26 September 2014. Oxidative stress and autophagy: the clash between damage and metabolic needsG Filomeni1,2, D De Zio1,2 and F Cecconi1,2

Hum Mol Genet. 2010 Sep 1; 19(17): 3413–3429.

Published online 2010 Jun 21. doi: 10.1093/hmg/ddq253

PMCID: PMC2916709

Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease

Benjamin R. Underwood,1 Sara Imarisio,1,2 Angeleen Fleming,1,3 Claudia Rose,1 Gauri Krishna,1,2 Phoebe Heard,2 Marie Quick,1,3 Viktor I. Korolchuk,1 Maurizio Renna,1 Sovan Sarkar,1 Moisés García-Arencibia,1 Cahir J. O’Kane,2 Michael P. Murphy,4 and David C. Rubinsztein1,*

Orthop Res. 2014 Jul;32(7):937-43. doi: 10.1002/jor.22608. Epub 2014 Mar 18.

Do antioxidants inhibit oxidative-stress-induced autophagy of tenofibroblasts?

Kim RJ1, Hah YS, Sung CM, Kang JR, Park HB.

Am J Clin Nutr 2005, vol. 81 no. 1 215S-217S Polyphenols: antioxidants and beyond.

Augustin Scalbert,

Ian T Johnson, and

Mike Saltmarsh

https://ajcn.nutrition.org/content/81/1/215S.full)

Med Sci Monit. 2008 Nov;14(11):CR547-51.

Vitamin C-lipid metabolites: uptake and retention and effect on plasma C-reactive protein and oxidized LDL levels in healthy volunteers.

Pancorbo D1, Vazquez C, Fletcher MA.

Suhong Xu, Andrew D. Chisholm. C. elegans Epidermal Wounding Induces a Mitochondrial ROS Burst that Promotes Wound Repair. Developmental Cell, 2014; 31 (1): 48 DOI: 10.1016/j.devcel.2014.08.002

mtDNA Mutagenesis Disrupts Pluripotent Stem Cell Function by Altering Redox Signaling. C

Riikka H. Hämäläinen,

Kati J. Ahlqvist,

Pekka Ellonen

Maija Lepistö,

Angela Logan,

Timo Otonkoski,

Michael P. Murphy,

Anu Suomalainen

Open Access

Cell Reports, Volume 11, Issue 10, p1614–1624, 16 June 2015 DOI: https://dx.doi.org/10.1016/j.celrep.2015.05.009

RESEARCH UPDATE

Brendan J. Guercio, Kaori Sato, Donna Niedzwiecki, Xing Ye, Leonard B. Saltz, Robert J. Mayer, Rex B. Mowat, Renaud Whittom, Alexander Hantel, Al Benson, Daniel Atienza, Michael Messino, Hedy Kindler, Alan Venook, Frank B. Hu, Shuji Ogino, Kana Wu, Walter C. Willett, Edward L. Giovannucci, Jeffrey A. Meyerhardt, and Charles S. Fuchs. Coffee Intake, Recurrence, and Mortality in Stage III Colon Cancer: Results From CALGB 89803 (Alliance). Journal of Clinical Oncology, August 2015 DOI: 10.1200/JCO.2015.61.5062

Saccharomyces boulardii CNCM I-745 supports regeneration of the intestinal microbiota after diarrheic dysbiosis – a review. Moré MI, Swidsinski A

Clinical and Experimental Gastroenterology August 2015 Volume 2015:8 Pages 237—255 DOI https://dx.doi.org/10.2147/CEG.S85574

The Effect of Body Posture on Brain Glymphatic Transport

Hedok Lee1,2,*, et al . The Journal of Neuroscience, 5 August 2015, 35(31): 11034-11044; (doi: 10.1523/JNEUROSCI.1625-15.2015).

Science 18 October 2013: Vol. 342 no. 6156 pp. 373-377 DOI: 10.1126/science.1241224. Sleep Drives Metabolite Clearance from the Adult Brain

Lulu Xie1,*, et al.

Gail D. Sckisel, Myriam N. Bouchlaka, Arta M. Monjazeb, Marka Crittenden, Brendan D. Curti, Danice E.C. Wilkins, Kory A. Alderson, Can M. Sungur, Erik Ames, Annie Mirsoian, Abhinav Reddy, Warren Alexander, Athena Soulika, Bruce R. Blazar, Dan L. Longo, Robert H. Wiltrout, William J. Murphy. Out-of-Sequence Signal 3 Paralyzes Primary CD4 T-Cell-Dependent Immunity. Immunity, 2015; 43 (2): 240 DOI: 10.1016/j.immuni.2015.06.023

Reiko Horai, Carlos R. Zárate-Bladés, Patricia Dillenburg-Pilla, Jun Chen, Jennifer L. Kielczewski, Phyllis B. Silver, Yingyos Jittayasothorn, Chi-Chao Chan, Hidehiro Yamane, Kenya Honda, Rachel R. Caspi. Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site. Immunity, 2015; 43 (2): 343 DOI: 10.1016/j.immuni.2015.07.014

Laura Steenbergen, Roberta Sellaro, Ann-Kathrin Stock, Christian Beste, Lorenza S. Colzato. γ-Aminobutyric acid (GABA) administration improves action selection processes: a randomised controlled trial. Scientific Reports, 2015; 5: 12770 DOI: 10.1038/srep12770

Denise K. Houston, Janet A. Tooze, Jamehl L. Demons, Brooke L. Davis, Rachel Shertzer-Skinner, Linda B. Kearsley, Stephen B. Kritchevsky, Jeff D. Williamson. Delivery of a Vitamin D Intervention in Homebound Older Adults Using a Meals-on-Wheels Program: A Pilot Study. Journal of the American Geriatrics Society, 2015; DOI: 10.1111/jgs.13610

Kevin D. Hall, Thomas Bemis, Robert Brychta, Kong Y. Chen, Amber Courville, Emma J. Crayner, Stephanie Goodwin, Juen Guo, Lilian Howard, Nicolas D. Knuth, Bernard V. Miller, Carla M. Prado, Mario Siervo, Monica C. Skarulis, Mary Walter, Peter J. Walter, Laura Yannai. Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity. Cell Metabolism, 2015; DOI: 10.1016/j.cmet.2015.07.021

August 2015

EDITOR’S NOTE

Nature 444, 1027-1031 (21 December 2006) | doi:10.1038/nature05414;

An obesity-associated gut microbiome with increased capacity for energy harvest

Peter J. Turnbaugh1, Ruth E. Ley1, Michael A. Mahowald1, Vincent Magrini2, Elaine R. Mardis1,2 & Jeffrey I. Gordon1

NEWSGluten psychosis: confirmation of a new clinical entity

Nutrients. 2015 Jul 8;7(7):5532-5539. Full text free online at https://www.mdpi.com/2072-6643/7/7/5235/htm.

Lionetti E1, Leonardi S2, Franzonello C3, Mancardi M4, Ruggieri M5, Catassi C6,7.

NUTRIGENOMICS

Dolinoy D. The agouti mouse model: an epigenetic biosensor for nutritional and environmental alterations on the fetal epigenome. Nutr Rev; 2008; 66

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1. Jacobs DR Jr, Gross MD, Tapsell LC. Food synergy: an operational concept for understanding nutrition. Am J Clin Nutr. 2009 May;89(5):1543S-1548S.

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10. Lister J, Fletcher PJ, Nobrega JN, Remington G. Behavioral effects of food-derived opioid-like peptides in rodents: Implications for schizophrenia? Pharmacol Biochem Behav. 2015 Jul;134:70-78.

Dohan FC. Wheat “consumption” and hospital admissions for schizophrenia during World War II. A preliminary report. Am J Clin Nutr. 1966;18:7–10.
Dohan FC, Harper EH, Clark MH, Rodrigue RB, Zigas V: Is schizophrenia rare if grain is rare? Biol Psychiatry1984, 19(3):385-399.
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Pacheco A, Easterling WS, Pryer MW: A pilot study of the ketogenic diet in schizophrenia. Am J Psychiatry1965, 121:1110-1111.
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Jackson J, Eaton W, Cascella N, Fasano A, Warfel D, Feldman S, Richardson C, Vyas G, Linthicum J, Santora D, Warren KR. A gluten-free diet in people with schizophrenia and anti-tissue transglutaminase or anti-gliadin antibodies. Schizophr Res. 2012;140:262–263.
20. Genuis SJ, Lobo RA. Gluten sensitivity presenting as a neuropsychiatric disorder. Gastroenterol Res Pract. 2014;2014:293206.21. Wang HR, Woo YS, Bahk WM. Caffeine-induced psychiatric manifestations: a review. Int Clin Psychopharmacol. 2015 Jul;30(4):179-82.

Hedges DW, Woon FL, Hoopes SP. Caffeine-induced psychosis. CNS Spectr. 2009 Mar;14(3):127-9.
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Peng PJ, Chiang KT, Liang CS. Low-dose caffeine may exacerbate psychotic symptoms in people with schizophrenia. J Neuropsychiatry Clin Neurosci. 2014 Apr 1;26(2):E41.

BONES

Arthroscopy. 2015 Apr;31(4):785-92. doi: 10.1016/j.arthro.2014.11.021) Epub 2015 Jan 27. Supplementary methods in the nonsurgical treatment of osteoarthritis.

Percope de Andrade MA1, Campos TV2, Abreu-E-Silva GM2.

Maturitas. 2014 Jul;78(3):184-7. doi: 10.1016/j.maturitas.2014.04.015. Epub 2014 May 1.What is the current status of chondroitin sulphate and glucosamine for the treatment of knee osteoarthritis? Henrotin Y1, Marty M2, Mobasheri A3.

J Pharm Pharm Sci. 2011;14(2):264-73. The glucosamine controversy; a pharmacokinetic issue. Aghazadeh-Habashi A1, Jamali F.

Management of Osteoarthritis with Avocado/Soybean Unsaponifiables

Blaine A. Christiansen, Simrit Bhatti, Ramin Goudarzi, Shahin Emami (Cartilage, 2105 Vol. 6(1) 30–44. , doi: 10.1177/1947603514554992).

Biological actions of curcumin on articular chondrocytes Y. Henrotiny* a , A. L. Clutterbuckz, D. Allawayx, E. M. Lodwigx, P. Harrisx, M. Mathy-Harterty, M. Shakibaeik and A. Mobasheri. Osteoarthritis and Cartilage (2010) 18, 141e149 ª 2009 doi:10.1016/j.joca.2009.10.002

Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management. Yves Henrotin, Fabian Priem and Ali Mobasheri. (SpringerPlus 2013, 2:56 doi:10.1186/2193-1801-2-56.

Nicholas A. Young, Michael S. Bruss, Mark Gardner, William L. Willis, Xiaokui Mo, Giancarlo R. Valiente, Yu Cao, Zhongfa Liu, Wael N. Jarjour, Lai-Chu Wu. Oral Administration of Nano-Emulsion Curcumin in Mice Suppresses Inflammatory-Induced NFκB Signaling and Macrophage Migration. PLoS ONE, 2014; 9 (11): e111559 DOI: 10.1371/journal.pone.0111559

Buhrmann, A. Mobasheri, F. Busch, C. Aldinger, R. Stahlmann, A. Montaseri, M. Shakibaei. Curcumin Modulates Nuclear Factor B (NF- B)-mediated Inflammation in Human Tenocytes in Vitro: ROLE OF THE PHOSPHATIDYLINOSITOL 3-KINASE/Akt PATHWAY. Journal of Biological Chemistry, 2011; 286 (32): 28556 DOI: 10.1074/jbc.M111.256180

RESEARCH

Alison Fildes, Judith Charlton, Caroline Rudisill, Peter Littlejohns, A. Toby Prevost, Martin C. Gulliford. Probability of an Obese Person Attaining Normal Body Weight: Cohort Study Using Electronic Health Records. American Journal of Public Health, 2015; e1 DOI: 10.2105/AJPH.2015.302773

Brianna Cote, Lisa Janssen Carlson, Deepa A. Rao, Adam W.G. Alani. Combinatorial resveratrol and quercetin polymeric micelles mitigate doxorubicin induced cardiotoxicity in vitro and in vivo. Journal of Controlled Release, 2015; 213: 128 DOI: 10.1016/j.jconrel.2015.06.040

Strekalova, D. Malin, D. M. Good, V. L. Cryns. Methionine Deprivation Induces a Targetable Vulnerability in Triple-Negative Breast Cancer Cells by Enhancing TRAIL Receptor-2 Expression. Clinical Cancer Research, 2015; 21 (12): 2780 DOI: 10.1158/1078-0432.CCR-14-2792
Shai Efrati, Haim Golan, Yair Bechor, Yifat Faran, Shir Daphna-Tekoah, Gal Sekler, Gregori Fishlev, Jacob N. Ablin, Jacob Bergan, Olga Volkov, Mony Friedman, Eshel Ben-Jacob, Dan Buskila. Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial. PLOS ONE, 2015; 10 (5): e0127012 DOI: 10.1371/journal.pone.0127012

Nneka M. George, Julia Whitaker, Giovana Vieira, Jerome T. Geronimo, Dwight A. Bellinger, Craig A. Fletcher, Joseph P. Garner. Antioxidant Therapies for Ulcerative Dermatitis: A Potential Model for Skin Picking Disorder. PLOS ONE, 2015 DOI: 10.1371/journal.pone.0132092

July 2015

IHCAN references July 2015

NEWS

Linde K, Berner MM, Kriston L; St John’s wort for major depression. Cochrane Database Syst Rev. 2008 Oct 8;(4):CD000448

BEN BROWN

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GUT

Ranking the impact of human health disorders on gut metabolism: Systemic lupus erythematosus and obesity as study cases. David Rojo et al. Scientific Reports 2015,

5, Article number: 8310. doi:10.1038/srep08310

Rojo D et al. Clostridium difficile heterogeneously impacts intestinal community architecture but drives stable metabolome responses. ISME J. 2015 Mar 10. doi: 10.1038/ismej.2015.32. [Epub ahead of print]

Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens

Frits Koning, Nature Reviews Rheumatology 2015, Published online

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High Proportions of People with Non-Celiac Wheat Sensitivity Have Autoimmune Disease or Anti-nuclear Antibodies. Carroccio A, et al. Gastroenterology 2015, May 27. pii: S0016-5085(15)00767-2. (doi: 10.1053/j.gastro.2015.05.040)

Unrecognized Celiac Disease in Children Presenting for Rheumatology Evaluation

Yekaterina Sherman, Pediatrics 2015 (doi: 10.1542/peds.2014-2379).

Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates

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NUTRIGENOMICS

Arnold GL, Saavedra-Matiz CA, Galvin-Parton PA, Erbe R, Devincentis E, Kronn D, et al. Lack of genotype-phenotype correlations and outcome in MCAD deficiency diagnosed by newborn screening in New York State. Mol Genet Metab [Internet]. 2010 Mar [cited 2015 Jun 16];99(3):263–8. Available from: https://www.sciencedirect.com/science/article/pii/S1096719209004818
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Thakkar K, Billa G. Treatment of vitamin B12 deficiency – methylcobalamine? cyanocobalamine? hydroxycobalamine? Clearing the confusion. Eur J Clin Nutr. 2015;69(1-2).
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RESEARCH

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

Sebastian Brandhorst et al. Cell Metabolism, Published Online: June 18, 2015.

DOI: https://dx.doi.org/10.1016/j.cmet.2015.05.012

Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression

Chia-Wei Cheng et al, Cell Stem Cell 2014, Volume 14, Issue 6, p810–823, 5 June 2014.

DOI: https://dx.doi.org/10.1016/j.stem.2014.04.014

Antoine Louveau, Igor Smirnov, Timothy J. Keyes, Jacob D. Eccles, Sherin J. Rouhani, J. David Peske, Noel C. Derecki, David Castle, James W. Mandell, Kevin S. Lee, Tajie H. Harris, Jonathan Kipnis. Structural and functional features of central nervous system lymphatic vessels. Nature, 2015; DOI: 10.1038/nature14432

Yasmine Belkaid et al. Bone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection. Immunity, June 2015 DOI: 10.1016/j.immuni.2015.05.011

Beatrice Alexandra Golomb, Alexis K. Bui. A Fat to Forget: Trans Fat Consumption and Memory. PLOS ONE, 2015; 10 (6): e0128129 DOI: 10.1371/journal.pone.0128129.

Gill, J. Hankey, A. Wright, S. Marczak, K. Hemming, D. Allerton, P. Ansley-Robson, R. Costa. The Impact of a 24-h Ultra-Marathon on Circulatory Endotoxin and Cytokine Profile. International Journal of Sports Medicine, 2015; DOI: 10.1055/s-0034-1398535

June 2015

IHCAN June references

NEWS

Fallaize R, Macready AL, Butler LT, et al. (2015). The perceived impact of the National Health Service on personalised nutrition service delivery among the UK public. British Journal of Nutrition 113(8):1271-1279. DOI: 1017/S0007114515000045

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Angela Man, Eugenio Bertelli, Silvia Rentini, Mari Regoli, Graham Briars, Mario Marini, Alastair Watson, Claudio Nicoletti. Age-associated modifications of intestinal permeability and innate immunity in human small intestine. Clinical Science, 2015; DOI: 10.1042/CS20150046

Papanikolaou Y, Brooks J, Reider C, Fulgoni VL (2014) Dietary Magnesium Usual Intake is Associated with Favorable Diabetes-Related Physiological Outcomes and Reduced Risk of Metabolic Syndrome: An NHANES 2001-2010 Analysis. J Hum Nutr Food Sci 2(4): 1044. https://www.jscimedcentral.com/Nutrition/nutrition-2-1038.pdf

Effects of Pycnogenol® on endothelial dysfunction in borderline hypertensive, hyperlipidemic, and hyperglycemic individuals: the borderline study

Hu S., Belcaro G., Cornelli U., Luzzi R., Cesarone M. R., Dugall M., Feragalli B., Errichi B., Ippolito E., Grossi M. G., Hosoi M., Gizzi G., Trignani M. International Angiology 2015 February;34(1):43-52.

Bret T. Howrey, M. Kristen Peek, Juliet M. McKee, Mukaila A. Raji, Kenneth J. Ottenbacher, and Kyriakos S. Markides

Chamomile Consumption and Mortality: A Prospective Study of Mexican Origin Older Adults. The Gerontologist first published online April 29, 2015 (doi:10.1093/geront/gnv051).

Daynea J Wallock-Richards, Jon Marles-Wright, David Clarke, Amarnath Maitra, Michael Dodds, Bryan Hanley, Dominic Campopiano. Molecular Basis of Streptococcus mutans Sortase A Inhibition by the Flavonoid Natural Product trans-Chalcone. Chem. Commun., 2015; DOI:10.1039/C5CC01816A

NEWSextra

Khan Z, Combadière C, Authier F-J et al. Slow CCL2-dependent translocation of biopersistent particles from muscle to brain. BMC Medicine 2013, 11:99. DOI: 10.1186/1741-7015-11-99.

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van Os J, Kapur S. Schizophrenia. Lancet. 2009 Aug 22;374(9690):635-45.

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Pauling L. Orthomolecular psychiatry. Varying the concentrations of substances normally present in the human body may control mental disease. Science. 1968;160(825):265-271

Ames BN, Elson-Schwab I, Silver EA. High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affi nity (increased K(m)): relevance to genetic disease and polymorphisms. Am J Clin Nutr. 2002;75(4):616-658.

Hoffer LJ: Orthomolecular psychiatry: past, pres­ent and future. J Orthomol Med, 2010; 25:56-66.

Prousky JE: The orthomolecular treatment of schizophrenia: a primer for clinicians. Townsend Lett Doctors Patients, 2007; February/March: 86-100.

Sarris J, et al. Nutritional medicine as mainstream in psychiatry. Lancet Psychiatry 2015; 271–74

ENVIRONMENTAL HEALTH

Aitana Lertxundi, Michela Baccini, Nerea Lertxundi, Eduardo Fano, Aritz Aranbarri, Maria Dolores Martínez, Mikel Ayerdi, Jon Álvarez, Loreto Santa-Marina, Miren Dorronsoro, Jesus Ibarluzea. Exposure to fine particle matter, nitrogen dioxide and benzene during pregnancy and cognitive and psychomotor developments in children at 15months of age. Environment International, 2015; 80: 33 DOI: 10.1016/j.envint.2015.03.007

Mark Pimentel, Walter Morales, Ali Rezaie, Emily Marsh, Anthony Lembo, James Mirocha, Daniel A. Leffler, Zachary Marsh, Stacy Weitsman, Kathleen S. Chua, Gillian M. Barlow, Enoch Bortey, William Forbes, Allen Yu, Christopher Chang. Development and Validation of a Biomarker for Diarrhea-Predominant Irritable Bowel Syndrome in Human Subjects. PLOS ONE, 2015; 10 (5): e0126438 DOI: 10.1371/journal.pone.0126438

Cosmetics

Sathyanarayana S, Karr CJ, Lozano P, Brown E, Calafat AM, Liu F, Swan SH. 2008. Baby care products: possible sources of infant phthalate exposure. Pediatrics. Feb;121(2):e260-8.

Swan SH, Main KM, Liu F, et al; Study for Future Families Research Team. 2005. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Health Perspect. Aug;113(8):1056-61.

Swan SH, Liu F, Hines M, Kruse RL, Wang C, Redmon JB, Sparks A, Weiss B. 2010. Prenatal phthalate exposure and reduced masculine play in boys. Int J Androl. Apr;33(2):259-69.

EFAsJoseph G Gleeson et al. Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome. Nature Genetics, May 2015 DOI: 10.1038/ng.3311

Andrew H Crosby et al. A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome. Nature Genetics, May 2015 DOI: 10.1038/ng.3313

Jaewoo Choi, Scott W. Leonard, Katherine Kasper, Melissa McDougall, Jan F. Stevens, Robert L. Tanguay, Maret G. Traber. Novel function of vitamin E in regulation of zebrafish (Danio rerio) brain lysophospholipids discovered using lipidomics. Journal of Lipid Research, 2015; jlr.M058941 DOI: 10.1194/jlr.M058941

Aron Barbey et al. Anterior cingulate cortex mediates the relationship between O3PUFAs and executive functions in APOE e4 carriers. Frontiers in Aging Neuroscience, May 2015 DOI: 10.3389/fnagi.2015.00087

Adrian Raine, Jill Portnoy, Jianghong Liu, Tashneem Mahoomed, Joseph R. Hibbeln. Reduction in behaviour problems with omega-3 supplementation in children aged 8-16 years: a randomized, double-blind, placebo-controlled, stratified, parallel-group trial. Journal of Child Psychology and Psychiatry, 2015; 56 (5): 509 DOI: 10.1111/jcpp.12314

Gong Cheng, Changzhen Fu, Hong Wang, C. Adoligbe, Shengjuan Wei, Shijun Li, Bijie Jiang, Hongbao Wang, Linsen Zan. Production of transgenic beef cattle rich in n-3 PUFAs by somatic cell nuclear transfer. Biotechnology Letters, 2015; DOI: 10.1007/s10529-015-1827-z

Hanna Shevalye, Matthew S Yorek, Lawrence J Coppey, Amey Holmes, Matthew M Harper, Randy H Kardon, Mark A. Yorek. Effect of enriching the diet with menhaden oil or daily treatment with resolvin D1 on neuropathy in a mouse model of type 2 diabetes. Journal of Neurophysiology, 2015; jn.00224.2015 DOI: 10.1152/jn.00224.2015

Xiaoming Jia, Mohammadreza Pakseresht, Nour Wattar, Jamie Wildgrube, Stephanie Sontag, Murphy Andrews, Fatheema Begum Subhan, Linda McCargar, Catherine J. Field. Women who take n-3 long-chain polyunsaturated fatty acid supplements during pregnancy and lactation meet the recommended intake. Applied Physiology, Nutrition, and Metabolism, 2015; 1 DOI: 10.1139/apnm-2014-0313

Molecular Psychiatry advance online publication 24 March 2015; doi: 10.1038/mp.2015.22).Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept studyM H Rapaport1, A A Nierenberg2, P J Schettler1, B Kinkead1, A Cardoos2, R Walker2 and D Mischoulon2

RESEARCH UPDATE

Bäckhed et al. Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life. Cell Host & Microbe, May 2015 DOI: 10.1016/j.chom.2015.04.004

Vangay et al. Antibiotics, Pediatric Dysbiosis, and Disease. Cell Host & Microbe, May 2015 DOI: 10.1016/j.chom.2015.04.006

Fujimura et al. Microbiota in Allergy and Asthma and the Emerging Relationship with the Gut Microbiome. Cell Host & Microbe, May 2015 DOI: 10.1016/j.chom.2015.04.007

Vandana Gulati, Pankaj Gulati, Ian H Harding, Enzo A Palombo. Exploring the anti- diabetic potential of Australian Aboriginal and Indian Ayurvedic plant extracts using cell-based assays. BMC Complementary and Alternative Medicine, 2015; 15 (1) DOI: 10.1186/s12906-015-0524-8

Esther Lopez-Garcia, Luz Leon-Muñoz, Pilar Guallar-Castillon, Fernando Rodríguez-Artalejo. Habitual Yoghurt Consumption and Health-Related Quality of Life: A Prospective Cohort Study. Journal of the Academy of Nutrition and Dietetics, 2015; 115 (1): 31 DOI: 10.1016/j.jand.2014.05.013

May 2015

IHCAN May references

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Gore, Wellington Pham Inhalable Curcumin: Offering the Potential for Translation to Imaging and Treatment of Alzheimer’s Disease. JAD 2015, Volume 44, Number 1, 2015. doi: 10.3233/JAD-140798. Ayelet Ziv-Gal, Wei Wang, Changqing Zhou, Jodi A. Flaws. The effects of in utero bisphenol A exposure on reproductive capacity in several generations of mice. Toxicology and Applied Pharmacology, 2015; DOI: 10.1016/j.taap.2015.03.003 Z. Liu, M. M. Hopkins, Z. Zhang, C. B. Quisenberry, L. C. Fix, B. M. Galvan, K. E. Meier. Omega-3 Fatty Acids and Other FFA4 Agonists Inhibit Growth Factor Signaling in Human Prostate Cancer Cells. Journal of Pharmacology and Experimental Therapeutics, 2014; 352 (2): 380 DOI: 10.1124/jpet.114.218974 M. Igarashi, R. A. Santos, S. Cohen-Cory. Impact of Maternal n-3 Polyunsaturated Fatty Acid Deficiency on Dendritic Arbor Morphology and Connectivity of Developing Xenopus laevis Central Neurons In Vivo. 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April 2015

GUT

Joe Pizzorno 1. Wikoff, WR, Anfora AT, Liu J, et al. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A. 2009;106(10):3698-3703. doi: 10.1073/pnas.0812874106 2. The Free Dictionary by Farlex. Endotoxin. https://medical-dictionary. thefreedictionary.com/endotoxin. Accessed October 31, 2014. 3. Neves AL, Coelho J, Couto L, et al. Metabolic endotoxemia: A molecular link between obesity and cardiovascular risk. J Mol Endocrinol. 2013;51(2):R51-R64 4. Cani PD, Amar J, Iglesias MA, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56(7):1761-1772. 5. Lassenius MI, Pietiläinen KH, Kaartinen K, et al. Bacterial endotoxin activity in human serum is associated with dyslipidemia, insulin resistance, obesity, and chronic inflammation. Diabetes Care. 2011;34(8):1809-1815. 6. Alisi A, Manco M, Devito R, et al. Endotoxin and plasminogen activator inhibitor-1 serum levels associated with nonalcoholic steatohepatitis in children. J Pediatr Gastroenterol Nutr. 2010;50(6):645-649. 7. Shah R, Hinkle CC, Haris L, et al. Adipose genes down-regulated during experimental endotoxemia are also suppressed in obesity. J Clin Endocrinol Metab. 2012;97(11):E2152-E2159. 8. Dial S, Delaney JA, Barkun AN, Suissa S. Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease. JAMA. 2005;294(23): 2989-2995. 9. Pizzorno J. Zonulin! The wheat conundrum solved (well, mostly …). Integrat Med Clin J. 2013;12(4):8-14. 10. de Kort S, Keszthelyi D, Masclee AA. Leaky gut and diabetes mellitus: What is the link? Obes Rev. 2011;12(6):449-458. 11. Leclercq S, Matamoros S, Cani PD, et al. Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity. Proc Natl Acad Sci U S A. 2014;111(42):E4485-E4493. 12. Sostres C, Gargallo CJ, Lanas A. Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage. Arthritis Res Ther. 2013;15(suppl 3):S3. 13. Buhner S, Buning C, Genschel J, et al. Genetic basis for increased intestinal permeability in families with Crohn’s disease: Role of CARD15 3020insC mutation? Gut. 2006;55(3):342-347. 14. Laugerette F, Vors C, Peretti N, et al. Complex links between dietary lipids, endogenous endotoxins and metabolic inflammation. Biochimie. 2011;93(1):39-45 HISTAMINE – Ben Brown 1. Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr. 2007 May;85(5):1185-96. 2. Amon U, Bangha E, Küster T, Menne A, Vollrath IB, Gibbs BF. Enteral histaminosis: Clinical implications. Inflamm Res. 1999 Jun;48(6):291-5. 3. Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr. 2007 May;85(5):1185-96. 4. Maintz L, et al. Histamine Intolerance in Clinical Practice. Dtsch Arztebl 2006; 103(51–52): A 3477–83 [English translation] doi: 10.1016/j.jand.2014.09.009 5. Kohn JB. Is there a diet for histamine intolerance? J Acad Nutr Diet. 2014 Nov;114(11):1860. 6. Rosell-Camps A, Zibetti S, Pérez-Esteban G, Vila-Vidal M, Ferrés-Ramis L, García-Teresa-García E. Histamine intolerance as a cause of chronic digestive complaints in pediatric patients. Rev Esp Enferm Dig. 2013 Apr;105(4):201-6. 7. Schwelberger HG. Histamine intolerance: a metabolic disease? Inflamm Res. 2010 Mar;59 Suppl 2:S219-21. doi: 10.1007/s00011-009-0134-3 8. García-Martin E, Mendoza JL, Martínez C, Taxonera C, Urcelay E, Ladero JM, de la Concha EG, Díaz-Rubio M, Agúndez JA. Severity of ulcerative colitis is associated with a polymorphism at diamine oxidase gene but not at histamine N-methyltransferase gene. World J Gastroenterol. 2006 Jan 28;12(4):615-20. 9. Szczepankiewicz A, Bręborowicz A, Sobkowiak P, Popiel A. Polymorphisms of two histamine-metabolizing enzymes genes and childhood allergic asthma: a case control study. Clin Mol Allergy. 2010 Nov 1;8:14. 10. García-Martín E, García-Menaya J, Sánchez B, Martínez C, Rosendo R, Agúndez JA. Polymorphisms of histamine-metabolizing enzymes and clinical manifestations of asthma and allergic rhinitis. Clin Exp Allergy. 2007 Aug;37(8):1175-82. 11. García-Martín E, Martínez C, Serrador M, Alonso-Navarro H, Ayuso P, Navacerrada F, Agúndez JA, Jiménez-Jiménez FJ. Diamine Oxidase rs10156191 and rs2052129 Variants Are Associated With the Risk for Migraine. Headache. 2015 Feb;55(2):276-86. doi: 10.1111/head.12493 12. Spencer M, Chey WD, Eswaran S. Dietary Renaissance in IBS: Has Food Replaced Medications as a Primary Treatment Strategy? Curr Treat Options Gastroenterol. 2014 Dec;12(4):424-40. doi: 10.1007/s11938-014-0031-x. 13. Schwelberger HG. Histamine intolerance: overestimated or underestimated? Inflamm Res. 2009 Apr;58 Suppl 1:51-2. doi: 10.1007/s00011-009-2004-4. 14. Wantke F, Götz M, Jarisch R. [The histamine-free diet]. Hautarzt. 1993 Aug;44(8):512-6. 15. Wantke F, Götz M, Jarisch R. Histamine-free diet: treatment of choice for histamine-induced food intolerance and supporting treatment for chronic headaches. Clin Exp Allergy. 1993 Dec;23(12):982-5. 16. Maintz L, Benfadal S, Allam JP, Hagemann T, Fimmers R, Novak N. Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema. J Allergy Clin Immunol. 2006 May;117(5):1106-12. 17. Chung BY, Cho SI, Ahn IS, Lee HB, Kim HO, Park CW, Lee CH. Treatment of Atopic Dermatitis with a Low-histamine Diet. Ann Dermatol. 2011 Sep;23 Suppl 1:S91-5. doi: 10.5021/ad.2011.23.S1.S91. 18. Hoffmann KM, Gruber E, Deutschmann A, Jahnel J, Hauer AC. Histamine intolerance in children with chronic abdominal pain. Arch Dis Child. 2013 Oct;98(10):832-3. doi: 10.1136/archdischild-2013-305024. 19. Rosell-Camps A, Zibetti S, Pérez-Esteban G, Vila-Vidal M, Ferrés-Ramis L, García-Teresa-García E. Histamine intolerance as a cause of chronic digestive complaints in pediatric patients. Rev Esp Enferm Dig. 2013 Apr;105(4):201-6. 20. Johnston CS, Martin LJ, Cai X. Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis. J Am Coll Nutr. 1992 Apr;11(2):172-6. 21. Martner-Hewes PM, Hunt IF, Murphy NJ, Swendseid ME, Settlage RH. Vitamin B-6 nutriture and plasma diamine oxidase activity in pregnant Hispanic teenagers. Am J Clin Nutr. 1986 Dec;44(6):907-13. 22. Büttner L, Achilles N, Böhm M, Shah-Hosseini K, Mösges R. Efficacy and tolerability of bromelain in patients with chronic rhinosinusitis–a pilot study. B-ENT. 2013;9(3):217-25 23. Oksaharju A, Kankainen M, Kekkonen RA, Lindstedt KA, Kovanen PT, Korpela R, Miettinen M. Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells. World J Gastroenterol. 2011 Feb 14;17(6):750-9. doi: 10.3748/wjg.v17.i6.750 24. Betsi GI, Papadavid E, Falagas ME. Probiotics for the treatment or prevention of atopic dermatitis: a review of the evidence from randomized controlled trials. Am J Clin Dermatol. 2008;9(2):93-103. GUT HEALTH and RESEARCH UPDATE Junki Miyamoto, Taichi Mizukure, Si-Bum Park, Shigenobu Kishino, Ikuo Kimura, Kanako Hirano, Paolo Bergamo, Mauro Rossi, Takuya Suzuki, Makoto Arita, Jun Ogawa, Soichi Tanabe. A Gut Microbial Metabolite of Linoleic Acid, 10-Hydroxy-cis-12-octadecenoic Acid, Ameliorates Intestinal Epithelial Barrier Impairment Partially via GPR40-MEK-ERK Pathway. Journal of Biological Chemistry, 2015; 290 (5): 2902 DOI: 10.1074/jbc.M114.610733 Am J Obstet Gynecol. 2015 Feb 14. pii: S0002-9378(15)00130-1. doi: 10.1016/j.ajog.2015.02.008. [Epub ahead of print] Impact of probiotics in women with gestational diabetes mellitus on metabolic health: a randomized controlled trial. Lindsay KL1, Brennan L2, Kennelly MA1, Maguire OC3, Smith T3, Curran S4, Coffey M5, Foley ME1, Hatunic M6, Shanahan F7, McAuliffe FM8. J F Vázquez-Castellanos, S Serrano-Villar, A Latorre, A Artacho, M L Ferrús, N Madrid, A Vallejo, T Sainz, J Martínez-Botas, S Ferrando-Martínez, M Vera, F Dronda, M Leal, J Del Romero, S Moreno, V Estrada, M J Gosalbes, A Moya. Altered metabolism of gut microbiota contributes to chronic immune activation in HIV-infected individuals. Mucosal Immunology, 2014; DOI: 10.1038/mi.2014.107 A. Morgun, A. Dzutsev, X. Dong, R. L. Greer, D. J. Sexton, J. Ravel, M. Schuster, W. Hsiao, P. Matzinger, N. Shulzhenko. Uncovering effects of antibiotics on the host and microbiota using transkingdom gene networks. Gut, 2015; DOI: 10.1136/gutjnl-2014-308820 Daniela Grimaldi, Federica Provini, Giulia Pierangeli, Natalia Mazzella, Giovanni Zamboni, Giulio Marchesini, Pietro Cortelli. Evidence of a diurnal thermogenic handicap in obesity. Chronobiology International, 2015; 32 (2): 299 DOI: 10.3109/07420528.2014.983603 Z. Liu, M. M. Hopkins, Z. Zhang, C. B. Quisenberry, L. C. Fix, B. M. Galvan, K. E. Meier. Omega-3 Fatty Acids and Other FFA4 Agonists Inhibit Growth Factor Signaling in Human Prostate Cancer Cells. Journal of Pharmacology and Experimental Therapeutics, 2014; 352 (2): 380 DOI: 10.1124/jpet.114.218974 Shaiju K. Vareed, Alison K. Bauer, Kavitha M. Nair, Yunbao Liu, Bolleddula Jayaprakasam, Muraleedharan G. Nair. Blood-Brain Barrier Permeability of Bioactive Withanamides Present in Withania somnifera Fruit Extract. Phytotherapy Research, 2014; 28 (8): 1260 DOI: 10.1002/ptr.5118 1. M. B. Azad, T. Konya, D. S. Guttman, C. J. Field, M. R. Sears, K. T. HayGlass, P. J. Mandhane, S. E. Turvey, P. Subbarao, A. B. Becker, J. A. Scott, A. L. Kozyrskyj. Infant gut microbiota and food sensitization: associations in the first year of life. Clinical & Experimental Allergy, 2015; 45 (3): 632 DOI: 10.1111/cea.12487 NEWS Benoit Chassaing, Omry Koren, Julia K. Goodrich, Angela C. Poole, Shanthi Srinivasan, Ruth E. Ley, Andrew T. Gewirtz. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature, 2015; DOI: 10.1038/nature14232 Lerner A1, Matthias T2. Autoimmun Rev. 2015 Feb 9. pii: S1568-9972(15)00024-5. doi: 10.1016/j.autrev.2015.01.009. [Epub ahead of print]. Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease. Nutrients. 2015 Feb 27;7(3):1565-76. doi: 10.3390/nu7031565. Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity. Hollon J, Puppa EL, Greenwald B, Goldberg E, Guerrerio A, Fasano A. Vazquez-Roque, M.I.; Camilleri, M.; Smyrk, T.; Murray, J.A.; Marietta, E.; O’Neill, J.; Carlson, P.; Lamsam, J.; Janzow, D.; Eckert, D.; et al. A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: Effects on bowel frequency and intestinal function. Gastroenterology 2013, 144, 903–911.e3. doi: 10.1053/j.gastro.2013.01.049.

NEW RELEASES Vojdani A. Detection of IgE, IgG, IgA and IgM antibodies against raw and processed food antigens. Nutr Metab (Lond). 2009 May 12;6:22. doi: 10.1186/1743-7075-6-22. CONFERENCE Oschman, J.L., 2008. Energy Medicine and Longevity. Chapter 27 in Anti-Aging Therapeutics, Volume X, Edited by Klatz, R. and Goldman, R., American Academy of Anti-Aging Medicine, Chicago IL, pp. 211-218.

March 2015

HEART

The Free Radical Theory of Aging Matures. Kenneth B. Beckman , Bruce N. Ames, Physiological Reviews Published 1 April 1998 Vol. 78 no. 2, 547-581. https://physrev.physiology.org/content/78/2/547. Mutagens and Multivitamins, by Megan Scudellari. The Scientist, June 1, 2014: https://www.the-scientist.com/?articles.view/articleNo/40054/title/Mutagens-and-Multivitamins. McCann et al. Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging? American Journal of Clinical Nutrition, 2009; DOI: 10.3945/ajcn.2009.27930 Ames et al. Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage. Proceedings of the National Academy of Sciences, 2006; 103 (47): 17589 DOI: 10.1073/pnas.0608757103 Li Wang, Peter L. Bordi, Jennifer A. Fleming, Alison M. Hill, and Penny M. Kris‐etherton. Effect of a Moderate Fat Diet With and Without Avocados on Lipoprotein Particle Number, Size and Subclasses in Overweight and Obese Adults: A Randomized, Controlled Trial. Journal of the American Heart Association, January 2015 DOI: 10.1161/JAHA.114.001355 Sarah A. Johnson, Arturo Figueroa, Negin Navaei, Alexei Wong, Roy Kalfon, Lauren T. Ormsbee, Rafaela G. Feresin, Marcus L. Elam, Shirin Hooshmand, Mark E. Payton, Bahram H. Arjmandi. Daily Blueberry Consumption Improves Blood Pressure and Arterial Stiffness in Postmenopausal Women with Pre- and Stage 1-Hypertension: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Journal of the Academy of Nutrition and Dietetics, 2015; DOI: 10.1016/j.jand.2014.11.001 Markus Juonala, Atte Voipio, Katja Pahkala, Jorma S. A. Viikari, Vera Mikkilä, Mika Kähönen, Nina Hutri-Kähönen, Antti Jula, David Burgner, Matthew A. Sabin, Jukka Marniemi, Britt-Marie Loo, Tomi Laitinen, Eero Jokinen, Leena Taittonen, Costan G. Magnussen, Olli T. Raitakari. Childhood 25-OH Vitamin D Levels and Carotid Intima-Media Thickness in Adulthood: The Cardiovascular Risk in Young Finns Study. The Journal of Clinical Endocrinology & Metabolism, 2015; jc.2014-3944 DOI: 10.1210/jc.2014-3944 NEWS Z. Harcombe, J. S. Baker, S. M. Cooper, B. Davies, N. Sculthorpe, J. J. DiNicolantonio, F. Grace. Evidence from randomised controlled trials did not support the introduction of dietary fat guidelines in 1977 and 1983: a systematic review and meta-analysis. Open Heart, 2015; 2 (1): e000196 DOI: 10.1136/openhrt-2014-000196 Bahl. The evidence base for fat guidelines: a balanced diet. Open Heart, 2015; 2 (1): e000229 DOI: 10.1136/openhrt-2014-000229 Jessie E. Green, Alan G. Brown, Punam Ohri-Vachaspati. Sociodemographic Disparities among Fast-Food Restaurant Customers Who Notice and Use Calorie Menu Labels. Journal of the Academy of Nutrition and Dietetics, 2015; DOI: 10.1016/j.jand.2014.12.004 Felicity L. Bishop, Lucy Yardley, Philip Prescott, Cyrus Cooper, Paul Little, George T. Lewith. Psychological Covariates of Longitudinal Changes in Back-related Disability in Patients Undergoing Acupuncture. The Clinical Journal of Pain, 2015; 31 (3): 254 DOI: 10.1097/AJP.0000000000000108 NEW RELEASES Stanislavov R, Rohdewald P (2014) PACR (Pine Bark Extract, L Arginine, L Citrulline, Rose Hip Extract) Improves Emotional, Physical Health and Sexual Function in Peri-Menopausal Women. J Women’s Health Care 3: 195. doi:10.4172/2167-0420.1000195.

IHCAN CONFERENCES Goodrich Julia K et al. Human genetics shape the gut microbiome. Cell 2014, 159(4): 789-99. DOI: https://dx.doi.org/10.1016/j.cell.2014.09.053 RESEARCH Natalia M. Grindler, Jenifer E. Allsworth, George A. Macones, Kurunthachalam Kannan, Kimberly A. Roehl, Amber R. Cooper. Persistent Organic Pollutants and Early Menopause in U.S. Women. PLOS ONE, 2015; 10 (1): e0116057 DOI: 10.1371/journal.pone.0116057 Nancy E. Avis, Sybil L. Crawford, Gail Greendale, Joyce T. Bromberger, Susan A. Everson-Rose, Ellen B. Gold, Rachel Hess, Hadine Joffe, Howard M. Kravitz, Ping G. Tepper, Rebecca C. Thurston. Duration of Menopausal Vasomotor Symptoms Over the Menopause Transition. JAMA Internal Medicine, 2015; DOI: 10.1001/jamainternmed.2014.8063 Gloria Richard-Davis, JoAnn E. Manson. Vasomotor Symptom Duration in Midlife Women—Research Overturns Dogma. JAMA Internal Medicine, 2015; DOI: 10.1001/jamainternmed.2014.8099 Jerome Sarris, PhD et al. Nutritional medicine as mainstream in psychiatry. The Lancet Psychiatry, January 2015 DOI: 10.1016/S2215-0366(14)00051-0 Sadeq A. Quraishi, Caitlin Mccarthy, Livnat Blum, J. Perren Cobb, and Carlos A. Camargo, Jr. Plasma 25-Hydroxyvitamin D Levels at Initiation of Care and Duration of Mechanical Ventilation in Critically Ill Surgical Patients. Journal of Parenteral and Enteral Nutrition, January 2015 DOI: 10.1177/0148607114566276. Méplan, Heinz Freisling, H.Bas Bueno-de-Mesquita, Sandra Hybsier, Niels-Peter Becker, Magdalena Czuban, Anne Tjønneland, Malene Outzen, Marie-Christine Boutron-Ruault, Antoine Racine, Nadia Bastide, Tilman Kühn, Rudolf Kaaks, Dimitrios Trichopoulos, Antonia Trichopoulou, Pagona Lagiou, Salvatore Panico, Petra H Peeters, Elisabete Weiderpass, Guri Skeie, Engeset Dagrun, Maria-Dolores Chirlaque, Maria-Jose Sánchez, Eva Ardanaz, Ingrid Ljuslinder, Maria Wennberg, Kathryn E Bradbury, Paolo Vineis, Alessio Naccarati, Domenico Palli, Heiner Boeing, Kim Overvad, Miren Dorronsoro, Paula Jakszyn, Amanda J. Cross, Jose Ramón Quirós, Magdalena Stepien, So Yeon Kong, Talita Duarte-Salles, Elio Riboli, John E. Hesketh. Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort. International Journal of Cancer, 2015; 136 (5): 1149 DOI: 10.1002/ijc.29071. Naiane F.B. Alves, Suênia K.P. Porpino, Matheus M.O. Monteiro, Enéas R.M. Gomes, Valdir A. Braga. Coconut oil supplementation and physical exercise improves baroreflex sensitivity and oxidative stress in hypertensive rats. Applied Physiology, Nutrition, and Metabolism, 2015; 1 DOI: 10.1139/apnm-2014-0351 Jj Strain, Alison J Yeates, Edwin Van Wijngaarden, Sally W Thurston, Maria S Mulhern, Emeir M Mcsorley, Gene E Watson, Tanzy M Love, Tristram H Smith, Kelley Yost, Donald Harrington, Conrad F Shamlaye, Juliette Henderson, Gary J Myers, and Philip W Davidson. Prenatal exposure to methyl mercury from fish consumption and polyunsaturated fatty acids: associations with child development at 20 mo of age in an observational study in the Republic of Seychelles. American Journal of Clinical Nutrition, January 2015 DOI: 10.3945/ajcn.114.100503 R. Richardson, M. M. Taylor, S. L. Shalat, T. S. Guillot, W. M. Caudle, M. M. Hossain, T. A. Mathews, S. R. Jones, D. A. Cory-Slechta, G. W. Miller. Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder. The FASEB Journal, 2015; DOI: 10.1096/fj.14-260901

February 2015

International Diabetes Federation. The global burden 2014. Available from: https://www.idf.org/diabetesatlas/5e/the-global-burden 1. Tinker LF, Bonds DE, Margolis KL, Manson JE, Howard BV, Larson J, Perri MG, Beresford SA, Robinson JG, Rodríguez B, Safford MM, Wenger NK, Stevens VJ, Parker LM; Women’s Health Initiative. Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women: the Women’s Health Initiative randomized controlled dietary modification trial. Arch Intern Med. 2008 Jul 28;168(14):1500-11. doi: 10.1001/archinte.168.14.1500.2. Ajala O, English P, Pinkney J. Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes. Am J Clin Nutr. 2013 Mar;97(3):505-16. doi: 10.3945/ajcn.112.042457.3. Action to Control Cardiovascular Risk in Diabetes Study Group, Gerstein HC, Miller ME, Byington RP, Goff DC Jr, Bigger JT, Buse JB, Cushman WC, Genuth S, Ismail-Beigi F, Grimm RH Jr, Probstfield JL, Simons-Morton DG, Friedewald WT. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008 Jun 12;358(24):2545-59. doi: 10.1056/NEJMoa0802743.4. Feinman RD, Pogozelski WK, Astrup A, Bernstein RK, Fine EJ, Westman EC, Accurso A, Frassetto L, Gower BA, McFarlane SI, Nielsen JV, Krarup T, Saslow L, Roth KS, Vernon MC, Volek JS, Wilshire GB, Dahlqvist A, Sundberg R, Childers A, Morrison K, Manninen AH, Dashti HM, Wood RJ, Wortman J, Worm N. Dietary carbohydrate restriction as the first approach in diabetes management: Critical review and evidence base. Nutrition. 2015 Jan;31(1):1-13. doi: 10.1016/j.nut.2014.06.011.5. Westman EC, Yancy WS Jr, Humphreys M. Dietary treatment of diabetes mellitus in the pre-insulin era (1914-1922). Perspect Biol Med 2006, 49(1):77-83.6. Feinman RD, Volek JS. Carbohydrate restriction as the default treatment for type 2 diabetes and metabolic syndrome. Scand Cardiovasc J 2008, Aug;42(4):256-63. doi: 10.1080/14017430802014838.7. Westman EC, Vernon MC. Has carbohydrate-restriction been forgotten as a treatment for diabetes mellitus? A perspective on the ACCORD study design. Nutr Metab (Lond) 2008 Apr 9;5:10. doi: 10.1186/1743-7075-5-10.

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Genetic testing: Anne Pemberton Feve A., 2012. Tyrosine Hydroxylase and Parkinsons Disease. CNS & neurological disorders drug targets. https://www.ncbi.nlm.nih.gov/pubmed/22583428. Melas, P et al., 2013. Genetic and epigenetic associations of MAOA and NR3C1 with depression and childhood adversities. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 16, pp.1513–28. https://www.ncbi.nlm.nih.gov/pubmed/23449091 Rajeevan MS et al, 2007. Glucocorticoid receptor polymorphisms and haplotypes associated with chronic fatigue syndrome. Genes, brain, and behavior, 6, pp.167–176. Sheehan K et al., 2005. Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD. Molecular psychiatry, 10, pp.944–949. Hu, Y et al, 2012. Genotyping performance between saliva and blood-derived genomic DNAS on the DMET array: A comparison. PLoS One. 2012;7(3):e33968. doi: 10.1371/journal.pone.0033968. In Practice Maturitas. 2003 Feb 25;44(2):133-40. Is hormone replacement therapy associated with an increased risk of irritable bowel syndrome? Ruigómez A, García Rodríguez LA, Johansson S, Wallander MA). Nicholas J. Talley, Alan R. Zinsmeister, and L. Joseph Melton III. Irritable Bowel Syndrome in a Community: Symptom Subgroups, Risk Factors, and Health Care Utilization Am. J. Epidemiol. (1995) 142 (1): 76-83. Mushrooms1. The anti-dementia effect of Lion’s Mane mushroom and its clinical application. Kawagishi H, Zhuang C, Shnidman E. Townsend Letter for Doctors and Patients, April 2004.

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Research Filip Scheperjans, Velma Aho, Pedro A. B. Pereira, Kaisa Koskinen, Lars Paulin, Eero Pekkonen, Elena Haapaniemi, Seppo Kaakkola, Johanna Eerola-Rautio, Marjatta Pohja, Esko Kinnunen, Kari Murros, Petri Auvinen. Gut microbiota are related to Parkinson’s disease and clinical phenotype. Movement Disorders, 2014; DOI: 10.1002/mds.26069 Aviroop Biswas, Paul I. Oh, Guy E. Faulkner, Ravi R. Bajaj, Michael A. Silver, Marc S. Mitchell, and David A. Alter. Sedentary Time and Its Association With Risk for Disease Incidence, Mortality, and Hospitalization in Adults: A Systematic Review and Meta-analysis. Annals of Internal Medicine, 2015 DOI: 10.7326/M14-1651 Petter Brodin, Vladimir Jojic, Tianxiang Gao, Sanchita Bhattacharya, Cesar J. Lopez Angel, David Furman, Shai Shen-Orr, Cornelia L. Dekker, Gary E. Swan, Atul J. Butte, Holden T. Maecker, Mark M. Davis. Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences. Cell, 2015; 160 (1-2): 37 DOI: 10.1016/j.cell.2014.12.020 Yasuhiko Kizuka, Shinobu Kitazume, Reiko Fujinawa, Takashi Saito, Nobuhisa Iwata, Takaomi C. Saido, Miyako Nakano,Yoshiki Yamaguchi, Yasuhiro Hashimoto, Matthias Staufenbiel, Hiroyuki Hatsuta, Shigeo Murayama, Hiroshi Manya, Tamao Endo, Naoyuki Taniguchi. An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer’s disease. EMBO Molecular Medicine, January 2015 DOI: 10.15252/emmm.201404438 Ulf Ekelund et al. Physical activity and all-cause mortality across levels of overall and abdominal adiposity in European men and women: the European Prospective Investigation into Cancer and Nutrition Study (EPIC). Am J Clin Nutr, January 14, 2015 DOI: 10.3945/ajcn.114.100065 Helen Lambert, Lynda Frassetto, J. Bernadette Moore, David Torgerson, Richard Gannon , Peter Burckhardt and Susan Lanham-New. The effect of supplementation with alkaline potassium salts on bone metabolism: a meta-analysis. Osteoporosis International, January 2015 DOI: 10.1007/s00198-014-3006-9. Emily Ho et al. SUV39H1/H3K9me3 attenuates sulforaphane-induced apoptotic signaling in PC3 prostate cancer cells. Oncogenesis, December 2014 DOI: 10.1038/oncsis.2014.47 News

Ouyang, M. P. Longnecker, S. A. Venners, S. Johnson, S. Korrick, J. Zhang, X. Xu, P. Christian, M.-C. Wang, X. Wang. Preconception serum 1,1,1-trichloro-2,2,bis(p-chlorophenyl)ethane and B-vitamin status: independent and joint effects on women’s reproductive outcomes. American Journal of Clinical Nutrition, 2014; 100 (6): 1470 DOI: 10.3945/ajcn.114.088377
Sona Kang, Linus T. Tsai, Yiming Zhou, Adam Evertts, Su Xu, Michael J. Griffin, Robbyn Issner, Holly J. Whitton, Benjamin A. Garcia, Charles B. Epstein, Tarjei S. Mikkelsen, Evan D. Rosen. Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis. Nature Cell Biology, 2014; 17 (1): 44 DOI: 10.1038/ncb3080

January 2015

News Michael D. Miedema, Faye L. Lopez, Michael J. Blaha, Salim S. Virani, Josef Coresh, Christie M. Ballantyne, Aaron R. Folsom. Eligibility for Statin Therapy According to New Cholesterol Guidelines and Prevalent Use of Medication to Lower Lipid Levels in an Older US Cohort. JAMA Internal Medicine 2014, DOI: 10.1001/jamainternmed.2014.6288 Application of new cholesterol guidelines to a population-based sample. Pencina MJ1, Navar-Boggan AM, D’Agostino RB Sr, Williams K, Neely B, Sniderman AD, Peterson ED N Engl J Med. 2014 Apr 10;370(15):1422-31. doi: 10.1056/NEJMoa1315665 . Stanley Blue, Elizabeth Shove, Chris Carmona, Michael P. Kelly. Theories of practice and public health: understanding (un)healthy practices. Critical Public Health, 2014; 1 DOI: 10.1080/09581596.2014.980396 Page 32, Research update CJ Watson, D Grando, CK Fairley, P Chondros, SM Garland, SP Myers, M Pirotta. The effects of oral garlic on vaginal candida colony counts: a randomised placebo controlled double-blind trial. BJOG: An International Journal of Obstetrics & Gynaecology, 2013; DOI: 10.1111/1471-0528.12518 M.C. Verdenelli, M.M. Coman, C. Cecchini, S. Silvi, C. Orpianesi, A. Cresci. Evaluation of antipathogenic activity and adherence properties of humanLactobacillusstrains for vaginal formulations. Journal of Applied Microbiology, 2014; DOI: 10.1111/jam.12459 Pranab K. Mukherjee, Jyotsna Chandra, Mauricio Retuerto, Masoumeh Sikaroodi, Robert E. Brown, Richard Jurevic, Robert A. Salata, Michael M. Lederman, Patrick M. Gillevet, Mahmoud A. Ghannoum. Oral Mycobiome Analysis of HIV-Infected Patients: Identification of Pichia as an Antagonist of Opportunistic Fungi. PLoS Pathogens, 2014; 10 (3): e1003996 DOI: 10.1371/journal.ppat.1003996 Nat Commun. 2013;4:1342. doi: 10.1038/ncomms2343. Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans. Smeekens SP1, Ng A, Kumar V, Johnson MD, Plantinga TS, van Diemen C, Arts P, Verwiel ET, Gresnigt MS, Fransen K, van Sommeren S, Oosting M, Cheng SC, Joosten LA, Hoischen A, Kullberg BJ, Scott WK, Perfect JR, van der Meer JW, Wijmenga C, Netea MG, Xavier RJ. Link to Free PMC Article Junhua Li et al. An integrated catalog of reference genes in the human gut microbiome. Nature Biotechnology, 2014; 32 (8): 834 DOI: 10.1038/nbt.2942 Benoit Chassaing, Ruth E. Ley, Andrew T. Gewirtz. Intestinal Epithelial Cell Toll-like Receptor 5 Regulates the Intestinal Microbiota to Prevent Low-Grade Inflammation and Metabolic Syndrome in Mice. Gastroenterology, 2014; 147 (6): 1363 DOI: 10.1053/j.gastro.2014.08.033 VA Hodgetts, RK Morris, A Francis, J Gardosi, KM Ismail. Effectiveness of folic acid supplementation in pregnancy on reducing the risk of small-for-gestational age neonates: a population study, systematic review and meta-analysis. BJOG: An International Journal of Obstetrics & Gynaecology, 2014; DOI: 10.1111/1471-0528.13202 Bärbel S Blaum, Jonathan P Hannan, Andrew P Herbert, David Kavanagh, Dušan Uhrín, Thilo Stehle. Structural basis for sialic acid–mediated self-recognition by complement factor H. Nature Chemical Biology, 2014; DOI: 10.1038/nchembio.1696 Mu Chen, Qi Sun, Edward Giovannucci, Dariush Mozaffarian, JoAnn E Manson, Walter C Willett, Frank B Hu. Dairy consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis. BMC Medicine, 2014; 12 (1): 215 DOI: 10.1186/s12916-014-0215-1
Warinner, J. Hendy, C. Speller, E. Cappellini, R. Fischer, C. Trachsel, J. Arneborg, N. Lynnerup, O. E. Craig, D. M. Swallow, A. Fotakis, R. J. Christensen, J. V. Olsen, A. Liebert, N. Montalva, S. Fiddyment, S. Charlton, M. Mackie, A. Canci, A. Bouwman, F. Rühli, M. T. P. Gilbert, M. J. Collins. Direct evidence of milk consumption from ancient human dental calculus. Scientific Reports, 2014; 4: 7104 DOI: 10.1038/srep07104
L. Tarry-Adkins, D. S. Fernandez-Twinn, J.-H. Chen, I. P. Hargreaves, M. S. Martin-Gronert, J. M. McConnell, S. E. Ozanne. Nutritional programming of coenzyme Q: potential for prevention and intervention? The FASEB Journal, 2014; 28 (12): 5398 DOI: 10.1096/fj.14-259473
Honda, Y. Nagai, T. Matsunaga, N. Okamoto, Y. Watanabe, K. Tsuneyama, H. Hayashi, I. Fujii, M. Ikutani, Y. Hirai, A. Muraguchi, K. Takatsu. Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation. Journal of Leukocyte Biology, 2014; 96 (6): 1087 DOI: 10.1189/jlb.3A0114-005RR
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